MCID: PLY019
MIFTS: 60

Polyneuropathy malady

Neuronal diseases category

Summaries for Polyneuropathy

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Wikipedia:65 Polyneuropathy or symmetrical polyneuropathy (poly- + neuro- + -pathy) is damage or disease affecting... more...

MalaCards based summary: Polyneuropathy, also known as polyneuropathy, unspecified, is related to diabetic polyneuropathy and neuropathy. An important gene associated with Polyneuropathy is TTR (transthyretin). The compounds deae and megestrol acetate have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and testes, and related mouse phenotypes are vision/eye and muscle.

Aliases & Classifications for Polyneuropathy

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 27ICD10
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Related Diseases for Polyneuropathy

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Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 510)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic polyneuropathy31.6NGF, AKR1B1
2neuropathy31.0PMP22, TTR, AKR1B1, NGF
3myopathy30.8PMP22, NGF, CD59
4guillain-barre syndrome30.6PMP22, TUBB
5diabetic neuropathy30.3GDNF, PMP22, NGF, AKR1B1, CNTF
6leukemia30.3GDNF, CD59, CNTF, IFNA2, TTR, AKR1B1
7autonomic neuropathy30.3AKR1B1, TTR, NGF
8melanoma30.1IFNA2, AKR1B1, TUBB, GDNF, CD59
9malaria30.1CNTF
10motor neuron disease29.9CNTF, GDNF
11ischemia29.8CNTF, CD59, AKR1B1, GDNF
12demyelinating disease29.7CNTF, NGF
13demyelinating polyneuropathy11.2
14chronic inflammatory demyelinating polyneuropathy11.1
15critical illness polyneuropathy10.8
16poems syndrome10.6
17chronic polyneuropathy10.5
18amyloidosis10.5
19hepatitis10.4
20myeloma10.4
21amyloidosis, hereditary, transthyretin-related10.4
22blindness10.3
23osteosclerotic myeloma10.3
24paraneoplastic polyneuropathy10.3
25hepatitis c10.2
26alcoholic neuropathy10.2
27ataxia10.2
28polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract10.2
29charcot-marie-tooth disease10.2
30myasthenia gravis10.2
31cerebritis10.2
32tooth disease10.2
33multifocal motor neuropathy10.2
34beriberi10.2
35endotheliitis10.2
36systemic lupus erythematosus10.2
37hepatitis c virus10.2
38churg-strauss syndrome10.2
39lupus erythematosus10.2
40respiratory failure10.2
41charcot-marie-tooth disease, x-linked recessive, 510.1
42hepatitis b10.1
43neuronitis10.1
44eosinophilia10.1
45peritonitis10.1
46hereditary motor and sensory neuropathy with agenesis of the corpus callosum10.1
47familial amyloidosis, finnish type10.1
48marek disease10.1
49polyneuropathy mental retardation acromicria premature menopause10.1
50dysautonomia10.1

Graphical network of the top 20 diseases related to Polyneuropathy:



Diseases related to polyneuropathy

Symptoms for Polyneuropathy

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Drugs & Therapeutics for Polyneuropathy

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Drug clinical trials:

Search ClinicalTrials for Polyneuropathy

Search NIH Clinical Center for Polyneuropathy

Genetic Tests for Polyneuropathy

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Anatomical Context for Polyneuropathy

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MalaCards organs/tissues related to Polyneuropathy:

33
Liver, Skin, Testes, Heart, Bone, T cells, Spinal cord, Endothelial, Bone marrow, Kidney, B cells, Brain, Pancreas, Lung, Myeloid, Breast, Nk cells, Neutrophil, Eye, Lymph node, Colon, Thyroid, Prostate, Thalamus, Dorsal root ganglion

Animal Models for Polyneuropathy or affiliated genes

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MGI Mouse Phenotypes related to Polyneuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4ABHD12, PMP22, NGF, TTR, AKR1B1
2MP:00053698.4CNTF, NGF, PMP22, ABHD12, GDNF
3MP:00053867.6GDNF, ABHD12, PMP22, NGF, FCGR2B, AKR1B1
4MP:00036317.5GDNF, ABHD12, PMP22, NGF, FCGR2B, DHH
5MP:00053767.4CD59, ABHD12, NGF, TTR, FCGR2B, AKR1B1

Publications for Polyneuropathy

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Articles related to Polyneuropathy:

(show top 50)    (show all 1838)
idTitleAuthorsYear
1
Sialylated IgG-Fc: a novel biomarker of chronic inflammatory demyelinating polyneuropathy. (25814494)
2015
2
Mobile biofeedback of heart rate variability in patients with diabetic polyneuropathy: a preliminary study. (24438496)
2014
3
Exercise interventions, gait, and balance in older subjects with distal symmetric polyneuropathy: a three-group randomized clinical trial. (24355993)
2014
4
Assessment of paclitaxel induced sensory polyneuropathy with "Catwalk" automated gait analysis in mice. (24143194)
2013
5
Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice. (24319678)
2013
6
CD19 as a Therapeutic Target in a Spontaneous Autoimmune Polyneuropathy. (24116957)
2013
7
Peripheral nociceptor sensitization mediates allodynia in patients with distal symmetric polyneuropathy. (23052607)
2013
8
A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy. (23393557)
2013
9
A case of paraneoplastic demyelinating motor polyneuropathy. (22649345)
2012
10
Neuromuscular ultrasound in the diagnosis of focal neuropathies superimposed on polyneuropathy: a case report. (21835689)
2012
11
Bortezomib and dexamethasone as first-line therapy for a patient with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes syndrome complicated by renal failure. (22553961)
2012
12
Relationship between amyloid deposition and intracellular structural changes in familial amyloidotic polyneuropathy. (21777941)
2012
13
Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects. (22734904)
2012
14
Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy--a case report. (22138026)
2012
15
Subacute inflammatory demyelinating polyneuropathy disclosed by massive nerve root enhancement in CMT1A. (22173780)
2012
16
Polyneuropathy due to cyclosporine A in patients with renal transplantation: a case report. (21545310)
2011
17
Polymorphisms of GSTT1, GSTM1, and EPHX genotypes in patients with cryptogenic polyneuropathy: a case-control study. (22399093)
2011
18
Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies. (19922956)
2010
19
Atypical childhood chronic inflammatory demyelinating polyneuropathy. (20589891)
2010
20
Alemtuzumab in the treatment of IVIG-dependent chronic inflammatory demyelinating polyneuropathy. (20049473)
2010
21
Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. (19720975)
2009
22
Immunoglobulin M deposition in cutaneous nerves of anti-myelin-associated glycoprotein polyneuropathy patients correlates with axonal degeneration. (19151627)
2009
23
SELDI-TOF mass spectrometry evaluation of variant transthyretins for diagnosis and pathogenesis of familial amyloidotic polyneuropathy. (19372189)
2009
24
Electrophysiology in chronic inflammatory demyelinating polyneuropathy with IGIV. (19260050)
2009
25
Quantitative sensation and autonomic test abnormalities in transthyretin amyloidosis polyneuropathy. (19618439)
2009
26
Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy. (19915301)
2009
27
Fatigue in chronic inflammatory demyelinating polyneuropathy. (19347932)
2009
28
Motor variant of chronic inflammatory demyelinating polyneuropathy in a child. (18486826)
2008
29
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. (18473286)
2008
30
A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy. (17306302)
2007
31
Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis. (17712474)
2007
32
Severe amyloid deposition in mammary glands of familial amyloid polyneuropathy patients. (17701472)
2007
33
The diagnosis and management of familial amyloid polyneuropathy]. (17086153)
2006
34
Organophosphate-induced delayed polyneuropathy. (16042503)
2005
35
Acute inflammatory demyelinating polyneuropathy in patients with pregnancy. (15269509)
2004
36
Clinical and pathological studies of cardiac amyloidosis in transthyretin type familial amyloid polyneuropathy. (14986482)
2003
37
Subarachnoid block for a patient with progressive chronic inflammatory demyelinating polyneuropathy. (11682419)
2001
38
A case of familial amyloid polyneuropathy homozygous for the transthyretin Val30Met gene with motor-dominant sensorimotor polyneuropathy and unusual sural nerve pathological findings. (11709003)
2001
39
A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. (10907124)
2000
40
Optic atrophy and chronic acquired polyneuropathy. (10098553)
1999
41
Genotypic-phenotypic variations in a series of 65 patients with familial amyloid polyneuropathy. (9748014)
1998
42
Focal lesions area feature of chronic inflammatory demyelinating polyneuropathy (CIDP). (9845290)
1998
43
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
44
Chronic inflammatory demyelinating polyneuropathy (CIDP) in diabetics. (8902721)
1996
45
Chronic inflammatory demyelinating polyneuropathy. (8907837)
1994
46
A critical assessment of vascular factors in the causation of diabetic polyneuropathy. (8334845)
1993
47
Magnetic resonance imaging of the cauda equina in chronic inflammatory demyelinating polyneuropathy. (8388677)
1993
48
Myocardiopathy caused by Portuguese-type familial amyloidotic polyneuropathy. Sequential morphologic and functional study of 60 patients]. (1807296)
1991
49
Chronic inflammatory demyelinating polyneuropathy. Conduction failure before and during immunoglobulin or plasma therapy. (2597997)
1989
50
Chronic inflammatory demyelinating polyneuropathy of infancy: a corticosteroid-responsive disorder. (3017185)
1986

Variations for Polyneuropathy

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Expression for genes affiliated with Polyneuropathy

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Search GEO for disease gene expression data for Polyneuropathy.

Pathways for genes affiliated with Polyneuropathy

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Compounds for genes affiliated with Polyneuropathy

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Compounds related to Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1deae459.9TUBB, TTR
2megestrol acetate459.8IFNA2, TTR
3vitamin-e459.7TTR, CNTF, IFNA2
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.5TUBB, NGF, IFNA2
5capsaicin45 3010.5AKR1B1, NGF, GDNF
6levodopa45 1310.4NGF, AKR1B1, GDNF
7epinephrine45 26 1311.4NGF, TTR, AKR1B1, IFNA2
8glycerol45 26 1311.4TUBB, NGF, AKR1B1, TTR
9cocaine45 1310.3GDNF, NGF, CNTF
10methionine459.3TUBB, TTR, IFNA2, CNTF
11valine459.3TUBB, NGF, TTR, IFNA2
12histamine45 30 2611.2NGF, FCGR2B, IFNA2, CNTF
13glutamine459.2AKR1B1, TTR, NGF, TUBB
14dihydrotestosterone45 30 26 1312.1PMP22, NGF, AKR1B1
15rituximab45 51 1311.1FCGR2B, CD59, IFNA2
16fitc459.1CD59, TUBB, FCGR2B
17actinomycin d459.1GDNF, NGF, AKR1B1, CNTF
18azathioprine45 3 51 1312.1NGF, IFNA2, CD59
19aspirin45 51 30 2612.0NGF, TTR, AKR1B1, CD59
20testosterone45 61 26 1312.0AKR1B1, CNTF, TTR, NGF, TUBB
21bromodeoxyuridine459.0CNTF, TUBB, GDNF
22ascorbic acid45 2610.0AKR1B1, IFNA2, PMP22, TTR, CNTF
23norepinephrine45 26 1311.0CNTF, AKR1B1, TTR, GDNF, NGF
24arginine459.0NGF, CNTF, AKR1B1, TTR, PMP22
25cyclosporin a45 30 6110.9AKR1B1, NGF, CD59, TTR
26gaba458.9CNTF, GDNF, PMP22, TUBB
27dopamine45 30 26 1311.9GDNF, NGF, TTR, IFNA2, CNTF
28thymidine45 269.8NGF, TUBB, CNTF, FCGR2B, IFNA2
29creatinine458.8TUBB, GDNF, NGF, TTR, AKR1B1
30vegf458.7NGF, IFNA2, CNTF, AKR1B1, GDNF
31glutamate458.7GDNF, TTR, CNTF, NGF, TUBB
32aspartate458.7PMP22, IFNA2, TTR, GDNF
33lactate458.7AKR1B1, CD59, TTR, TUBB
34inositol458.6FCGR2B, CD59, AKR1B1
35genistein45 30 61 3 26 1313.6CNTF, GDNF, NGF, FCGR2B, AKR1B1, TTR
36forskolin45 51 1310.5PMP22, NGF, TUBB, GDNF, CNTF
37iron45 269.5IFNA2, CD59, GDNF, TTR
38adenylate458.5GDNF, AKR1B1, TTR, NGF, TUBB, CNTF
39retinoic acid45 269.3GDNF, TTR, NGF, PMP22, IFNA2, CNTF
40estrogen458.3AKR1B1, TUBB, FCGR2B, GDNF, TTR, IFNA2
41superoxide45 269.3IFNA2, GDNF, FCGR2B, CNTF, CD59
42ganglioside458.3PMP22, NGF, CD59, CNTF, GDNF
43glucose458.0TTR, IFNA2, CNTF, CD59, GDNF, AKR1B1
44alanine458.0IFNA2, TTR, CNTF, TUBB, NGF, GDNF
45oxygen45 268.9AKR1B1, CD59, GDNF, IFNA2, TUBB
46phosphatidylinositol457.8CD59, GDNF, FCGR2B, CNTF, TUBB, NGF
47cysteine457.8AKR1B1, TTR, NGF, PMP22, TUBB, GDNF
48lipid457.7TUBB, FCGR2B, GDNF, CD59, CNTF, IFNA2
49serine457.5GDNF, TUBB, PMP22, NGF, TTR, FCGR2B
50tyrosine457.4GDNF, TUBB, NGF, IFNA2, CNTF, CD59

GO Terms for genes affiliated with Polyneuropathy

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Cellular components related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:00432188.8CD59, PMP22
2extracellular regionGO:00055767.9GDNF, NGF, TTR, IFNA2, CD59
3extracellular spaceGO:00056157.5IFNA2, NGF, TTR, AKR1B1, CD59, CNTF

Biological processes related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.6CNTF, IFNA2
2adult locomotory behaviorGO:00083449.5NGF, GDNF
3peripheral nervous system developmentGO:00074229.3NGF, PMP22
4negative regulation of neuron apoptotic processGO:00435249.2CNTF, NGF, GDNF

Molecular functions related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.2CNTF, NGF, GDNF

Products for genes affiliated with Polyneuropathy

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Sources for Polyneuropathy

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet