MCID: PLY019
MIFTS: 64

Polyneuropathy malady

Neuronal diseases category

Summaries for Polyneuropathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Polyneuropathy or symmetrical polyneuropathy (poly- + neuro- + -pathy) is damage (peripheral neuropathy)... more...

MalaCards: Polyneuropathy, also known as polyneuropathy, unspecified, is related to diabetic polyneuropathy and neuropathy. An important gene associated with Polyneuropathy is TTR (transthyretin), and among its related pathways are Influenza A and Cell adhesion molecules (CAMs). The compounds cysteine and lipid have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and testes, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Polyneuropathy

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Polyneuropathy

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17GeneCards, 18GeneDecks
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Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 463)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic polyneuropathy31.5AKR1B1, NGF
2neuropathy30.9MPZ, TTR, AKR1B1, NGF, PMP22, MAG
3myopathy30.7GSN, PMP22, MPZ, NGF
4amyloidosis30.6TTR, GSN
5diabetes mellitus30.6AKR1B1, TNF, PMP22, AIRE, NGF
6diabetic neuropathy30.5NGF, GDNF, CNTF, PMP22, AKR1B1, MPZ
7myeloma30.5CD28, CNTF, MAG, IFNA2
8hepatitis30.4TTR, AIRE, IFNA2
9leukemia30.3GSN, GDNF, NGF, CNTF, TTR, IFNA2
10familial transthyretin amyloidosis30.3GSN, TTR
11hepatitis c30.3IFNA2, TNF, CD28
12myasthenia gravis30.2CD28, AIRE, MAG
13guillain-barre syndrome30.2MPZ, TUBB, PMP22
14multiple sclerosis30.1TNF, MPZ, MAG, TUBB, NGF, CD1D
15melanoma30.1IFNA2, GSN, TNF, AKR1B1, MAG, CD28
16charcot-marie-tooth disease30.1PMP22, MPZ
17peritonitis30.1TNF
18autonomic neuropathy30.1TTR, NGF, AKR1B1
19lupus erythematosus30.1FCGR2B
20tooth disease30.1PMP22, MPZ
21amyotrophic lateral sclerosis30.0CNTF, MAG, GDNF, NGF
22hepatitis b30.0IFNA2, AKR1B1
23pneumonia30.0TNF
24malaria29.9CNTF, TNF
25dementia29.9NGF
26cerebral amyloid angiopathy29.9TTR
27vasculitis29.9IFNA2, TNF
28diabetic autonomic neuropathy29.9AKR1B1, NGF
29parkinson's disease29.9NGF, GDNF
30ischemia29.8AKR1B1, AIF1, CNTF, GDNF
31arthritis29.8FCGR2B, TNF
32motor neuron disease29.8GDNF, CNTF
33breast cancer29.8TUBB, GSN
34finnish type amyloidosis29.8GSN, TTR
35chronic inflammatory demyelinating polyradiculoneuropathy29.8MPZ, PMP22
36encephalitis29.8CNTF
37hereditary neuropathy with liability to pressure palsies29.8PMP22
38rheumatoid arthritis29.6CNTF, FCGR2B, CD1D, CD28, TNF
39neuritis29.6PMP22, AIF1, MPZ
40asthma29.6GSN, CD28, TNF, NGF
41myocardial infarction29.6AKR1B1
42meningitis29.6GDNF
43sarcoidosis29.6CD28, TNF
44charcot-marie-tooth disease type 4e29.6MPZ, PMP22
45neuroblastoma29.6NGF
46diabetic retinopathy29.6AKR1B1
47psoriasis29.6NGF, TNF, CD28
48deficiency anemia29.6TTR, IFNA2
49herpes simplex29.6GDNF
50optic neuritis29.6MAG, MPZ

Graphical network of the top 20 diseases related to Polyneuropathy:



Diseases related to polyneuropathy

Clinical Features for Polyneuropathy

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Drugs & Therapeutics for Polyneuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Polyneuropathy

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Anatomical Context for Polyneuropathy

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32MalaCards
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MalaCards organs/tissues related to Polyneuropathy:

32
Liver, Skin, Testes, Bone, Heart, T cells, Endothelial, Spinal cord, Bone marrow, Kidney, B cells, Pancreas, Brain, Myeloid, Lung, Breast, Nk cells, Thalamus, Prostate, Thyroid, Colon, Lymph node, Eye, Dorsal root ganglion

Animal Models for Polyneuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polyneuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.2GSN, PMP22, TNF, MPZ, AIRE, MAG
2MP:000538611.1PMP22, TNF, AKR1B1, MPZ, AIRE, MAG
3MP:000537611.1CNTF, AIRE, MPZ, AKR1B1, TNF, NGF
4MP:000539711.0TNF, MPZ, AIRE, CNTF, CD1D, CD28
5MP:000538710.9CNTF, AIRE, MPZ, TNF, CD1D, CD28
6MP:000538410.9AIRE, MPZ, TNF, PMP22, CNTF, CD1D
7MP:001076810.8PMP22, TNF, AKR1B1, MPZ, AIRE, NGF
8MP:000539110.7TNF, AKR1B1, AIRE, NGF, CD28, ABHD12
9MP:000537910.6GSN, FCGR2B, GDNF, TNF
10MP:000538510.4TNF, NGF, CD1D, CD28, GDNF, CLDN5

Publications for Polyneuropathy

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50PubMed
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Articles related to Polyneuropathy:

(show top 50)    (show all 1736)
idTitleAuthorsYear
1
The antiallodynic action of nortriptyline and terbutaline is mediated by I^2 adrenoceptors and I' opioid receptors in the ob/ob model of diabetic polyneuropathy. (24361988)
2014
2
Reduced myocardial 123-iodine metaiodobenzylguanidine uptake: a prognostic marker in familial amyloid polyneuropathy. (23833285)
2013
3
High resolution sonography in the evaluation of the peripheral nervous system in polyneuropathy--a review of the literature. (23701599)
2013
4
Influence of a specific, biorhythmically defined physical stimulus on deficient vasomotion in small-caliber arterioles in the subcutis in patients with diabetic polyneuropathy. (24021603)
2013
5
Corneal nerve loss detected with corneal confocal microscopy is symmetrical and related to the severity of diabetic polyneuropathy. (23877983)
2013
6
Detection of diphtheritic polyneuropathy by acute flaccid paralysis surveillance, India. (23965520)
2013
7
Association of social support with quality of life in patients with polyneuropathy. (23521642)
2013
8
The impact of common variation in the definition of diabetic sensorimotor polyneuropathy on the validity of corneal in vivo confocal microscopy in patients with type 1 diabetes: a brief report. (23266297)
2013
9
Observations on chronic inflammatory demyelinating polyneuropathy: A plea for a rigorous approach to diagnosis and treatment. (23663896)
2013
10
Neuromuscular ultrasound in polyneuropathies and motor neuron disease. (23629869)
2013
11
Is chronic levodopa therapy associated with distal symmetric polyneuropathy in Parkinson's disease? (23146348)
2013
12
A designer drug for amyloid polyneuropathy. (22843277)
2012
13
Single-nucleotide polymorphism of transient axonal glycoprotein-1 and its correlation with clinical features and prognosis in chronic inflammatory demyelinating polyneuropathy. (22462668)
2012
14
Spinal cord stimulation markedly ameliorated refractory neuropathic pain in transthyretin Val30Met familial amyloid polyneuropathy. (21504341)
2011
15
Letter: diabetic polyneuropathy and cardiovascular complications in type 2 diabetic patients (diabetes metab j 2011;35:390-6). (22111049)
2011
16
Serial nerve conduction studies in vitamin B12 deficiency-associated polyneuropathy. (20890625)
2011
17
Skin intrinsic fluorescence correlates with autonomic and distal symmetrical polyneuropathy in individuals with type 1 diabetes. (21307380)
2011
18
Bell's palsy with concomitant idiopathic cranial nerve polyneuropathy in seven dogs. (21726231)
2011
19
Atypical childhood chronic inflammatory demyelinating polyneuropathy. (20589891)
2010
20
I+B-crystallin (HspB5) in familial amyloidotic polyneuropathy. (20804537)
2010
21
Acute-onset chronic inflammatory demyelinating polyneuropathy with cranial nerve involvement, dysautonomia, respiratory failure, and autoantibodies. (19918775)
2010
22
Some considerations on atypical cases of Charcot-Marie-Tooth disease and use of genetic testing in idiopathic polyneuropathies. (20800965)
2010
23
Cost-utility of Intravenous Immunoglobulin (IVIG) compared with corticosteroids for the treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) in Canada. (20565778)
2010
24
Chronic inflammatory demyelinating polyneuropathy in a patient infected with human T lymphotropic virus type I. (21857879)
2009
25
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. (18473286)
2008
26
Fatigue as the presenting symptom of chronic inflammatory demyelinating polyneuropathy. (19012289)
2008
27
Classifications and treatment responses in chronic immune-mediated demyelinating polyneuropathy. (17485651)
2007
28
Chronic inflammatory demyelinating polyneuropathy: a 6-year retrospective clinical study of a hospital-based population. (17258131)
2007
29
Polyneuropathy associated with IgG/IgA monoclonal gammopathy: a clinical and electrophysiological study of 15 cases. (14641513)
2003
30
Sodium valproate in painful diabetic polyneuropathy. (14616298)
2003
31
Rehabilitation of a patient with critical illness polyneuropathy (CIP) following acute respiratory failure: a case report and review of literature. (12623617)
2003
32
Nerve growth factor (NGF) in treatment of diabetic polyneuropathy. One hope less?]. (11433707)
2001
33
Chronic inflammatory demyelinating polyneuropathy and membranous glomerulonephropathy: report of two cases. (19078657)
2001
34
Vitamin B6 supplementation can improve peripheral polyneuropathy in patients with chronic renal failure on high-flux haemodialysis and human recombinant erythropoietin. (10978399)
2000
35
Development of cyroglobulinemia and polyneuropathy in a chronic myeloid leukemia patient during interferon-alpha treatment]. (10355142)
1999
36
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. (10499773)
1999
37
POEMS syndrome with xanthomatous cells. Polyneuropathy Organomegaly Endocrinopathy M-protein Skin changes. (10608252)
1999
38
Polyneuropathy with minifascicle formation in a patient with 46XY mixed gonadal dysgenesis. (10483790)
1999
39
Asymmetrical polyneuropathy with a stepwise progressive course and well-demarcated areas of demyelination. (10417801)
1999
40
Effect of orthotopic liver transplantation on the progression of familial amyloidotic polyneuropathy. (9565095)
1998
41
Antibody panels in idiopathic polyneuropathy and motor neuron disease. (9324084)
1997
42
Treatment of patients with chronic inflammatory demyelinating polyneuropathy. (8881435)
1996
43
Treatment of chronic inflammatory demyelinating polyneuropathy with cyclosporin-A. (8708650)
1996
44
Are autoimmune mechanisms involved in critical illness polyneuropathy? (7560486)
1995
45
Motor nerve refractory period distribution assessed by two techniques in diabetic polyneuropathy. (7521291)
1994
46
Chronic inflammatory demyelinating polyneuropathy: histological and immunopathological studies on biopsied sural nerves. (7707076)
1994
47
Plasma-cell dyscrasia with polyneuropathy. The spectrum of POEMS syndrome. (1333569)
1992
48
Characterization of a transthyretin-related amyloid fibril protein from cerebral amyloid angiopathy in type I familial amyloid polyneuropathy. (1517749)
1992
49
Myocardiopathy caused by Portuguese-type familial amyloidotic polyneuropathy. Sequential morphologic and functional study of 60 patients]. (1807296)
1991
50
Chronic and remitting painful diabetic polyneuropathy. Correlations with clinical features and subsequent changes in neurophysiology. (3338378)
1988

Genetic Variations for Polyneuropathy

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Expression for genes affiliated with Polyneuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyneuropathy

Search GEO for disease gene expression data for Polyneuropathy.

Pathways for genes affiliated with Polyneuropathy

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29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Polyneuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6FCGR2B, CD28, TNF, IFNA2
210.6MPZ, MAG, CD28, CLDN5
310.6GDNF, MAG, AIF1, TNF
4
Hide members
10.5NGF, MAG

Compounds for genes affiliated with Polyneuropathy

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44Novoseek, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank, 49PharmGKB
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Compounds related to Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1cysteine4411.3IFNA2, GSN, TTR, TUBB, PMP22, AKR1B1
2lipid4411.3CNTF, IFNA2, CD28, GDNF, CD1D, TNF
3tyrosine4411.3MPZ, AIRE, FCGR2B, GDNF, CD28, MAG
4retinoic acid44 2412.3CD1D, GDNF, TTR, GSN, AIF1, NGF
5alanine4411.2MAG, IFNA2, AKR1B1, GSN, CNTF, NGF
6serine4411.2AKR1B1, FCGR2B, GDNF, MAG, MPZ, PMP22
7genistein44 28 59 2 11 2416.2FCGR2B, GDNF, CD28, CNTF, AKR1B1, TNF
8calcium44 49 11 2414.2TUBB, AIF1, CLDN5, MAG, CNTF, NGF
9aspartate4411.2IFNA2, MAG, GSN, PMP22, MPZ, TTR
10adenylate4411.2TTR, GSN, NGF, CNTF, AKR1B1, TUBB
11thymidine44 2412.2IFNA2, TNF, MAG, CNTF, NGF, FCGR2B
12ganglioside4411.1CNTF, NGF, GDNF, MAG, PMP22, MPZ
13ascorbic acid44 2412.1IFNA2, AKR1B1, MAG, CNTF, TTR, PMP22
14methionine4411.1IFNA2, CNTF, MPZ, GSN, TUBB, TTR
15phosphatidylinositol4411.1TUBB, NGF, CD28, GDNF, FCGR2B, GSN
16dopamine44 28 11 2414.1GSN, GDNF, IFNA2, NGF, TTR, CNTF
17superoxide44 2412.1TNF, IFNA2, GDNF, FCGR2B, CNTF, GSN
18dihydrotestosterone44 28 11 2414.1PMP22, AKR1B1, MPZ, NGF, GSN
19bromodeoxyuridine4411.1GDNF, AIF1, MPZ, TUBB, CNTF
20creatinine4411.1NGF, GDNF, TTR, AKR1B1, MPZ
21testosterone44 59 11 2414.0NGF, CNTF, AKR1B1, TUBB, TTR, GSN
22phosphotyrosine4411.0GSN, TUBB, NGF, MAG, CD28
23histamine44 28 2413.0TNF, CNTF, NGF, FCGR2B, IFNA2
24rituximab44 49 1113.0TNF, MAG, FCGR2B, IFNA2
25oxygen44 2412.0CD28, AKR1B1, TNF, GDNF, GSN
26ly2940024411.0CNTF, TNF, GDNF, NGF, CD28
27wortmannin4411.0GDNF, CD28, NGF, CNTF, GSN
28actinomycin d4411.0CNTF, AKR1B1, TNF, GDNF, NGF
29forskolin44 49 1113.0PMP22, CNTF, NGF, TUBB, GDNF
30glutamate4411.0GDNF, GSN, CNTF
31norepinephrine44 11 2413.0TTR, CNTF, GDNF
32vegf4410.9TNF, GDNF, AKR1B1, NGF, CNTF, IFNA2
33arginine4410.9MPZ, NGF, CNTF, PMP22, AKR1B1, TTR
34cyclosporin a44 28 5912.9NGF, AKR1B1, TTR, CD28
353-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4410.9NGF, TUBB, IFNA2
36valine4410.9TUBB, NGF, TTR, IFNA2
37etanercept44 49 1112.9TNF, FCGR2B, IFNA2
38ceramide4410.9TNF, NGF, CD28, CD1D
39alpha lipoic acid4410.9AKR1B1, NGF, TNF
40glycerol44 11 2412.9TTR, NGF, AKR1B1, TUBB
41threonine4410.9TTR, CD28, MAG, CNTF, NGF, TUBB
42glycolipid4410.8MAG, CD1D, MPZ
43ivig4410.8TNF, MAG, FCGR2B
44capsaicin44 2811.7AKR1B1, NGF, GDNF
45melphalan44 1111.7TNF, TTR, IFNA2
46gaba4410.7PMP22, TUBB, CNTF, GDNF
47neopterin4410.6IFNA2, TNF, TTR
48indomethacin44 59 28 1113.6AKR1B1, NGF
49epinephrine44 11 2412.5TTR, NGF, AKR1B1, IFNA2
50cyclic amp44 2411.3MAG, CNTF, NGF, CD28, GDNF

GO Terms for genes affiliated with Polyneuropathy

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16Gene Ontology
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Cellular components related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8GSN, TTR, DHH, NGF, CNTF, AKR1B1
2phagocytic cupGO:00189110.5AIF1, TNF
3paranode region of axonGO:03327010.5MAG, CLDN5
4plasma membraneGO:00588610.5PMP22, TUBB, TNF, MPZ, AIRE, MAG
5Schmidt-Lanterman incisureGO:04322010.4CLDN5, MAG

Biological processes related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1humoral immune responseGO:00695910.6CD28, AIRE, TNF
2apoptotic signaling pathwayGO:09719010.6CD28, NGF, TNF
3positive regulation of T cell proliferationGO:04210210.6CD28, CD1D, AIF1
4inflammatory responseGO:00695410.5IFNA2, TNF, AIF1, NGF
5negative regulation of neuron apoptotic processGO:04352410.3CNTF, NGF, GDNF

Molecular functions related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.6TTR, CLDN5, CD28, AIRE, TNF

Products for genes affiliated with Polyneuropathy

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  • Antibodies
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Sources for Polyneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet