MCID: PLY019
MIFTS: 52

Polyneuropathy malady

Neuronal diseases category

Summaries for Polyneuropathy

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Wikipedia:63 Polyneuropathy or symmetrical polyneuropathy (poly- + neuro- + -pathy) is damage or disease affecting... more...

MalaCards based summary: Polyneuropathy, also known as polyneuropathy, unspecified, is related to diabetic polyneuropathy and neuropathy. An important gene associated with Polyneuropathy is TTR (transthyretin). The compounds deae and megestrol acetate have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and testes, and related mouse phenotypes are vision/eye and muscle.

Aliases & Classifications for Polyneuropathy

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 38NCIt, 25ICD10
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Related Diseases for Polyneuropathy

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Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 510)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic polyneuropathy32.0NGF, AKR1B1
2neuropathy31.0AKR1B1, TTR, NGF, PMP22
3guillain-barre syndrome30.7PMP22, TUBB
4malaria30.7CNTF
5myopathy30.6CD59, NGF, PMP22
6autonomic neuropathy30.5AKR1B1, TTR, NGF
7motor neuron disease30.0CNTF, GDNF
8demyelinating disease30.0NGF, CNTF
9diabetic neuropathy29.9GDNF, PMP22, NGF, AKR1B1, CNTF
10ischemia29.4GDNF, AKR1B1, CNTF, CD59
11melanoma29.4GDNF, TUBB, AKR1B1, IFNA2, CD59
12leukemia29.3GDNF, NGF, TTR, AKR1B1, IFNA2, CNTF
13demyelinating polyneuropathy11.2
14chronic inflammatory demyelinating polyneuropathy11.1
15critical illness polyneuropathy10.8
16poems syndrome10.6
17chronic polyneuropathy10.5
18amyloidosis10.5
19hepatitis10.4
20myeloma10.4
21amyloidosis, hereditary, transthyretin-related10.4
22blindness10.3
23corneal disease10.3NGF, AKR1B1
24diabetic autonomic neuropathy10.3NGF, AKR1B1
25osteosclerotic myeloma10.3
26carpal tunnel syndrome, familial10.3TTR, PMP22
27paraneoplastic polyneuropathy10.3
28hepatitis c10.2
29ataxia10.2
30polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract10.2
31charcot-marie-tooth disease10.2
32myasthenia gravis10.2
33cerebritis10.2
34tooth disease10.2
35central nervous system disease10.2CNTF, TTR, NGF
36multifocal motor neuropathy10.2
37beriberi10.2
38alcoholic neuropathy10.2
39endotheliitis10.2
40factor vii deficiency10.2IFNA2, NGF
41systemic lupus erythematosus10.2
42hepatitis c virus10.2
43churg-strauss syndrome10.2
44lupus erythematosus10.2
45respiratory failure10.2
46polyneuropathy mental retardation acromicria premature menopause10.2
47axonal polyneuropathy associated with igg/igm/iga monoclonal gammopathy10.2
48polyneuropathy associated with igm monoclonal gammapathy with anti-mag10.2
49prolactinoma10.2CNTF, NGF
50spinal muscular atrophy10.1CNTF, GDNF

Graphical network of the top 20 diseases related to Polyneuropathy:



Diseases related to polyneuropathy

Symptoms for Polyneuropathy

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Drugs & Therapeutics for Polyneuropathy

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Drug clinical trials:

Search ClinicalTrials for Polyneuropathy

Search NIH Clinical Center for Polyneuropathy

Genetic Tests for Polyneuropathy

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Anatomical Context for Polyneuropathy

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MalaCards organs/tissues related to Polyneuropathy:

31
Liver, Skin, Testes, Heart, Bone, T cells, Spinal cord, Endothelial, Bone marrow, Kidney, B cells, Brain, Pancreas, Lung, Myeloid, Breast, Nk cells, Neutrophil, Eye, Lymph node, Colon, Thyroid, Prostate, Thalamus, Dorsal root ganglion

Animal Models for Polyneuropathy or affiliated genes

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MGI Mouse Phenotypes related to Polyneuropathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4ABHD12, PMP22, NGF, TTR, AKR1B1
2MP:00053698.4CNTF, NGF, PMP22, ABHD12, GDNF
3MP:00053867.6GDNF, ABHD12, PMP22, NGF, FCGR2B, AKR1B1
4MP:00036317.5GDNF, ABHD12, PMP22, NGF, FCGR2B, DHH
5MP:00053767.4CD59, ABHD12, NGF, TTR, FCGR2B, AKR1B1

Publications for Polyneuropathy

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Articles related to Polyneuropathy:

(show top 50)    (show all 1838)
idTitleAuthorsYear
1
Sialylated IgG-Fc: a novel biomarker of chronic inflammatory demyelinating polyneuropathy. (25814494)
2015
2
Mobile biofeedback of heart rate variability in patients with diabetic polyneuropathy: a preliminary study. (24438496)
2014
3
Exercise interventions, gait, and balance in older subjects with distal symmetric polyneuropathy: a three-group randomized clinical trial. (24355993)
2014
4
Assessment of paclitaxel induced sensory polyneuropathy with "Catwalk" automated gait analysis in mice. (24143194)
2013
5
Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice. (24319678)
2013
6
CD19 as a Therapeutic Target in a Spontaneous Autoimmune Polyneuropathy. (24116957)
2013
7
Peripheral nociceptor sensitization mediates allodynia in patients with distal symmetric polyneuropathy. (23052607)
2013
8
A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy. (23393557)
2013
9
A case of paraneoplastic demyelinating motor polyneuropathy. (22649345)
2012
10
Neuromuscular ultrasound in the diagnosis of focal neuropathies superimposed on polyneuropathy: a case report. (21835689)
2012
11
Bortezomib and dexamethasone as first-line therapy for a patient with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes syndrome complicated by renal failure. (22553961)
2012
12
Relationship between amyloid deposition and intracellular structural changes in familial amyloidotic polyneuropathy. (21777941)
2012
13
Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects. (22734904)
2012
14
Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy--a case report. (22138026)
2012
15
Subacute inflammatory demyelinating polyneuropathy disclosed by massive nerve root enhancement in CMT1A. (22173780)
2012
16
Polyneuropathy due to cyclosporine A in patients with renal transplantation: a case report. (21545310)
2011
17
Polymorphisms of GSTT1, GSTM1, and EPHX genotypes in patients with cryptogenic polyneuropathy: a case-control study. (22399093)
2011
18
Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies. (19922956)
2010
19
Atypical childhood chronic inflammatory demyelinating polyneuropathy. (20589891)
2010
20
Alemtuzumab in the treatment of IVIG-dependent chronic inflammatory demyelinating polyneuropathy. (20049473)
2010
21
Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. (19720975)
2009
22
Immunoglobulin M deposition in cutaneous nerves of anti-myelin-associated glycoprotein polyneuropathy patients correlates with axonal degeneration. (19151627)
2009
23
SELDI-TOF mass spectrometry evaluation of variant transthyretins for diagnosis and pathogenesis of familial amyloidotic polyneuropathy. (19372189)
2009
24
Electrophysiology in chronic inflammatory demyelinating polyneuropathy with IGIV. (19260050)
2009
25
Quantitative sensation and autonomic test abnormalities in transthyretin amyloidosis polyneuropathy. (19618439)
2009
26
Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy. (19915301)
2009
27
Fatigue in chronic inflammatory demyelinating polyneuropathy. (19347932)
2009
28
Motor variant of chronic inflammatory demyelinating polyneuropathy in a child. (18486826)
2008
29
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. (18473286)
2008
30
A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy. (17306302)
2007
31
Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis. (17712474)
2007
32
Severe amyloid deposition in mammary glands of familial amyloid polyneuropathy patients. (17701472)
2007
33
The diagnosis and management of familial amyloid polyneuropathy]. (17086153)
2006
34
Organophosphate-induced delayed polyneuropathy. (16042503)
2005
35
Acute inflammatory demyelinating polyneuropathy in patients with pregnancy. (15269509)
2004
36
Clinical and pathological studies of cardiac amyloidosis in transthyretin type familial amyloid polyneuropathy. (14986482)
2003
37
Subarachnoid block for a patient with progressive chronic inflammatory demyelinating polyneuropathy. (11682419)
2001
38
A case of familial amyloid polyneuropathy homozygous for the transthyretin Val30Met gene with motor-dominant sensorimotor polyneuropathy and unusual sural nerve pathological findings. (11709003)
2001
39
A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. (10907124)
2000
40
Optic atrophy and chronic acquired polyneuropathy. (10098553)
1999
41
Genotypic-phenotypic variations in a series of 65 patients with familial amyloid polyneuropathy. (9748014)
1998
42
Focal lesions area feature of chronic inflammatory demyelinating polyneuropathy (CIDP). (9845290)
1998
43
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
44
Chronic inflammatory demyelinating polyneuropathy (CIDP) in diabetics. (8902721)
1996
45
Chronic inflammatory demyelinating polyneuropathy. (8907837)
1994
46
A critical assessment of vascular factors in the causation of diabetic polyneuropathy. (8334845)
1993
47
Magnetic resonance imaging of the cauda equina in chronic inflammatory demyelinating polyneuropathy. (8388677)
1993
48
Myocardiopathy caused by Portuguese-type familial amyloidotic polyneuropathy. Sequential morphologic and functional study of 60 patients]. (1807296)
1991
49
Chronic inflammatory demyelinating polyneuropathy. Conduction failure before and during immunoglobulin or plasma therapy. (2597997)
1989
50
Chronic inflammatory demyelinating polyneuropathy of infancy: a corticosteroid-responsive disorder. (3017185)
1986

Variations for Polyneuropathy

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Expression for genes affiliated with Polyneuropathy

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Search GEO for disease gene expression data for Polyneuropathy.

Pathways for genes affiliated with Polyneuropathy

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Compounds for genes affiliated with Polyneuropathy

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Compounds related to Polyneuropathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1deae439.9TTR, TUBB
2megestrol acetate439.8IFNA2, TTR
3vitamin-e439.7TTR, IFNA2, CNTF
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.5IFNA2, NGF, TUBB
5capsaicin43 2810.5AKR1B1, NGF, GDNF
6levodopa43 1210.4GDNF, NGF, AKR1B1
7epinephrine43 24 1211.4NGF, TTR, AKR1B1, IFNA2
8glycerol43 24 1211.4TUBB, NGF, TTR, AKR1B1
9cocaine43 1210.3CNTF, NGF, GDNF
10methionine439.3TUBB, TTR, IFNA2, CNTF
11valine439.3TUBB, NGF, TTR, IFNA2
12histamine43 28 2411.2CNTF, IFNA2, FCGR2B, NGF
13glutamine439.2AKR1B1, TTR, NGF, TUBB
14dihydrotestosterone43 28 24 1212.1PMP22, NGF, AKR1B1
15rituximab43 49 1211.1CD59, IFNA2, FCGR2B
16fitc439.1CD59, FCGR2B, TUBB
17actinomycin d439.1CNTF, AKR1B1, NGF, GDNF
18azathioprine43 2 49 1212.1CD59, IFNA2, NGF
19aspirin43 49 28 2412.0NGF, TTR, AKR1B1, CD59
20testosterone43 59 24 1212.0TUBB, NGF, TTR, AKR1B1, CNTF
21bromodeoxyuridine439.0CNTF, TUBB, GDNF
22ascorbic acid43 2410.0PMP22, TTR, AKR1B1, IFNA2, CNTF
23norepinephrine43 24 1211.0GDNF, NGF, TTR, AKR1B1, CNTF
24arginine439.0PMP22, NGF, TTR, AKR1B1, CNTF
25cyclosporin a43 28 5910.9NGF, TTR, AKR1B1, CD59
26gaba438.9CNTF, PMP22, TUBB, GDNF
27dopamine43 28 24 1211.9CNTF, IFNA2, TTR, NGF, GDNF
28thymidine43 249.8TUBB, NGF, FCGR2B, IFNA2, CNTF
29creatinine438.8GDNF, TUBB, NGF, TTR, AKR1B1
30vegf438.7GDNF, NGF, AKR1B1, IFNA2, CNTF
31glutamate438.7GDNF, TUBB, NGF, TTR, CNTF
32aspartate438.7GDNF, PMP22, TTR, IFNA2
33lactate438.7TUBB, TTR, AKR1B1, CD59
34inositol438.6CD59, AKR1B1, FCGR2B
35genistein43 28 59 2 24 1213.6GDNF, NGF, TTR, FCGR2B, AKR1B1, CNTF
36forskolin43 49 1210.5GDNF, TUBB, PMP22, NGF, CNTF
37iron43 249.5GDNF, TTR, IFNA2, CD59
38adenylate438.5GDNF, TUBB, NGF, TTR, AKR1B1, CNTF
39retinoic acid43 249.3GDNF, PMP22, NGF, TTR, IFNA2, CNTF
40estrogen438.3GDNF, TUBB, TTR, FCGR2B, AKR1B1, IFNA2
41superoxide43 249.3GDNF, FCGR2B, IFNA2, CNTF, CD59
42ganglioside438.3CD59, CNTF, NGF, PMP22, GDNF
43glucose438.0GDNF, TTR, AKR1B1, IFNA2, CNTF, CD59
44alanine438.0GDNF, TUBB, NGF, TTR, AKR1B1, IFNA2
45oxygen43 248.9GDNF, TUBB, AKR1B1, IFNA2, CD59
46phosphatidylinositol437.8GDNF, TUBB, NGF, FCGR2B, CNTF, CD59
47cysteine437.8GDNF, TUBB, PMP22, NGF, TTR, AKR1B1
48lipid437.7GDNF, TUBB, FCGR2B, IFNA2, CNTF, CD59
49serine437.5GDNF, TUBB, PMP22, NGF, TTR, FCGR2B
50tyrosine437.4GDNF, TUBB, NGF, FCGR2B, IFNA2, CNTF

GO Terms for genes affiliated with Polyneuropathy

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Cellular components related to Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:00432188.8PMP22, CD59
2extracellular regionGO:00055767.9CD59, IFNA2, TTR, NGF, GDNF
3extracellular spaceGO:00056157.5CD59, CNTF, IFNA2, DHH, AKR1B1, TTR

Biological processes related to Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.6CNTF, IFNA2
2adult locomotory behaviorGO:00083449.5NGF, GDNF
3peripheral nervous system developmentGO:00074229.3NGF, PMP22
4negative regulation of neuron apoptotic processGO:00435249.2CNTF, NGF, GDNF

Molecular functions related to Polyneuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.2CNTF, NGF, GDNF

Products for genes affiliated with Polyneuropathy

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Sources for Polyneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet