MCID: PLY019
MIFTS: 60

Polyneuropathy malady

Neuronal diseases category
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Summaries for Polyneuropathy

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65Wikipedia, 33MalaCards
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Wikipedia:65 Polyneuropathy or symmetrical polyneuropathy (poly- + neuro- + -pathy) is damage or disease affecting... more...

MalaCards: Polyneuropathy, also known as polyneuropathy, unspecified, is related to diabetic polyneuropathy and neuropathy. An important gene associated with Polyneuropathy is TTR (transthyretin). The compounds deae and megestrol acetate have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and testes, and related mouse phenotypes are vision/eye and muscle.

Aliases & Classifications for Polyneuropathy

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Related Diseases for Polyneuropathy

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17GeneCards, 18GeneDecks
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Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 494)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic polyneuropathy31.6NGF, AKR1B1
2neuropathy31.0AKR1B1, TTR, NGF, PMP22
3myopathy30.7CD59, NGF, PMP22
4carpal tunnel syndrome30.6TTR, PMP22
5guillain-barre syndrome30.4PMP22, TUBB
6diabetic neuropathy30.2GDNF, PMP22, NGF, AKR1B1, CNTF
7autonomic neuropathy30.2AKR1B1, TTR, NGF
8leukemia30.1GDNF, NGF, TTR, AKR1B1, IFNA2, CNTF
9malaria30.1CNTF
10multiple sclerosis30.1TUBB, NGF, CNTF, CD59
11amyotrophic lateral sclerosis30.1CNTF, NGF, GDNF
12melanoma30.0GDNF, TUBB, AKR1B1, IFNA2, CD59
13parkinson's disease30.0CNTF, TTR, NGF, GDNF
14motor neuron disease29.9CNTF, GDNF
15ischemia29.8GDNF, AKR1B1, CNTF, CD59
16demyelinating polyneuropathy11.1
17chronic inflammatory demyelinating polyneuropathy11.1
18critical illness polyneuropathy10.8
19poems syndrome10.6
20chronic polyneuropathy10.5
21amyloidosis10.4
22diabetes mellitus10.4
23myeloma10.4
24transthyretin amyloidosis10.3
25hepatitis10.3
26sepsis10.3
27blindness10.3
28osteosclerotic myeloma10.3
29paraneoplastic polyneuropathy10.3
30subacute inflammatory demyelinating polyneuropathy10.3
31hepatitis c10.2
32myasthenia gravis10.2
33type 1 diabetes mellitus10.2
34beriberi10.2
35cerebritis10.2
36alcoholic neuropathy10.2
37polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract10.2
38ataxia10.2
39endotheliitis10.2
40charcot-marie-tooth disease10.1
41respiratory failure10.1
42optic atrophy polyneuropathy deafness10.1
43hepatitis c virus10.1
44neuronitis10.1
45churg-strauss syndrome10.1
46systemic lupus erythematosus10.1
47eosinophilia10.1
48lupus erythematosus10.1
49peritonitis10.1
50tooth disease10.1

Graphical network of the top 20 diseases related to Polyneuropathy:



Diseases related to polyneuropathy

Symptoms for Polyneuropathy

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Drugs & Therapeutics for Polyneuropathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Polyneuropathy

Search NIH Clinical Center for Polyneuropathy

Genetic Tests for Polyneuropathy

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Anatomical Context for Polyneuropathy

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33MalaCards
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MalaCards organs/tissues related to Polyneuropathy:

33
Liver, Skin, Testes, Bone, T cells, Heart, Endothelial, Spinal cord, Kidney, B cells, Bone marrow, Brain, Pancreas, Myeloid, Breast, Nk cells, Thalamus, Prostate, Thyroid, Lung, Colon, Lymph node, Eye, Dorsal root ganglion

Animal Models for Polyneuropathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Polyneuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4ABHD12, AKR1B1, TTR, NGF, PMP22
2MP:00053698.4GDNF, CNTF, NGF, PMP22, ABHD12
3MP:00053867.6PMP22, CNTF, AKR1B1, ABHD12, FCGR2B, GDNF
4MP:00036317.5CNTF, DHH, FCGR2B, NGF, PMP22, ABHD12
5MP:00053767.4NGF, ABHD12, TTR, FCGR2B, AKR1B1, DHH

Publications for Polyneuropathy

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52PubMed
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Articles related to Polyneuropathy:

(show top 50)    (show all 1719)
idTitleAuthorsYear
1
Exercise interventions, gait, and balance in older subjects with distal symmetric polyneuropathy: a three-group randomized clinical trial. (24355993)
2014
2
Assessment of paclitaxel induced sensory polyneuropathy with "Catwalk" automated gait analysis in mice. (24143194)
2013
3
Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice. (24319678)
2013
4
CD19 as a Therapeutic Target in a Spontaneous Autoimmune Polyneuropathy. (24116957)
2013
5
Peripheral nociceptor sensitization mediates allodynia in patients with distal symmetric polyneuropathy. (23052607)
2013
6
A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy. (23393557)
2013
7
A case of paraneoplastic demyelinating motor polyneuropathy. (22649345)
2012
8
Neuromuscular ultrasound in the diagnosis of focal neuropathies superimposed on polyneuropathy: a case report. (21835689)
2012
9
Bortezomib and dexamethasone as first-line therapy for a patient with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes syndrome complicated by renal failure. (22553961)
2012
10
Relationship between amyloid deposition and intracellular structural changes in familial amyloidotic polyneuropathy. (21777941)
2012
11
Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects. (22734904)
2012
12
Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy--a case report. (22138026)
2012
13
Subacute inflammatory demyelinating polyneuropathy disclosed by massive nerve root enhancement in CMT1A. (22173780)
2012
14
Painful polyneuropathy secondary to prolonged treatment with linezolid: presentation of a case. (22217521)
2012
15
Polyneuropathy due to cyclosporine A in patients with renal transplantation: a case report. (21545310)
2011
16
Polymorphisms of GSTT1, GSTM1, and EPHX genotypes in patients with cryptogenic polyneuropathy: a case-control study. (22399093)
2011
17
Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies. (19922956)
2010
18
Atypical childhood chronic inflammatory demyelinating polyneuropathy. (20589891)
2010
19
Alemtuzumab in the treatment of IVIG-dependent chronic inflammatory demyelinating polyneuropathy. (20049473)
2010
20
Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. (19720975)
2009
21
Immunoglobulin M deposition in cutaneous nerves of anti-myelin-associated glycoprotein polyneuropathy patients correlates with axonal degeneration. (19151627)
2009
22
SELDI-TOF mass spectrometry evaluation of variant transthyretins for diagnosis and pathogenesis of familial amyloidotic polyneuropathy. (19372189)
2009
23
Electrophysiology in chronic inflammatory demyelinating polyneuropathy with IGIV. (19260050)
2009
24
Quantitative sensation and autonomic test abnormalities in transthyretin amyloidosis polyneuropathy. (19618439)
2009
25
Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy. (19915301)
2009
26
Fatigue in chronic inflammatory demyelinating polyneuropathy. (19347932)
2009
27
Motor variant of chronic inflammatory demyelinating polyneuropathy in a child. (18486826)
2008
28
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. (18473286)
2008
29
A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy. (17306302)
2007
30
Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis. (17712474)
2007
31
Severe amyloid deposition in mammary glands of familial amyloid polyneuropathy patients. (17701472)
2007
32
The diagnosis and management of familial amyloid polyneuropathy]. (17086153)
2006
33
Organophosphate-induced delayed polyneuropathy. (16042503)
2005
34
Acute inflammatory demyelinating polyneuropathy in patients with pregnancy. (15269509)
2004
35
Clinical and pathological studies of cardiac amyloidosis in transthyretin type familial amyloid polyneuropathy. (14986482)
2003
36
Subarachnoid block for a patient with progressive chronic inflammatory demyelinating polyneuropathy. (11682419)
2001
37
A case of familial amyloid polyneuropathy homozygous for the transthyretin Val30Met gene with motor-dominant sensorimotor polyneuropathy and unusual sural nerve pathological findings. (11709003)
2001
38
A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. (10907124)
2000
39
Optic atrophy and chronic acquired polyneuropathy. (10098553)
1999
40
Genotypic-phenotypic variations in a series of 65 patients with familial amyloid polyneuropathy. (9748014)
1998
41
Focal lesions area feature of chronic inflammatory demyelinating polyneuropathy (CIDP). (9845290)
1998
42
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
43
Chronic inflammatory demyelinating polyneuropathy (CIDP) in diabetics. (8902721)
1996
44
Chronic inflammatory demyelinating polyneuropathy. (8907837)
1994
45
A critical assessment of vascular factors in the causation of diabetic polyneuropathy. (8334845)
1993
46
Magnetic resonance imaging of the cauda equina in chronic inflammatory demyelinating polyneuropathy. (8388677)
1993
47
Myocardiopathy caused by Portuguese-type familial amyloidotic polyneuropathy. Sequential morphologic and functional study of 60 patients]. (1807296)
1991
48
A novel variant of transthyretin (Tyr114 to Cys) deduced from the nucleotide sequences of gene fragments from familial amyloidotic polyneuropathy in Japanese sibling cases. (2161654)
1990
49
Chronic inflammatory demyelinating polyneuropathy. Conduction failure before and during immunoglobulin or plasma therapy. (2597997)
1989
50
Chronic inflammatory demyelinating polyneuropathy of infancy: a corticosteroid-responsive disorder. (3017185)
1986

Variations for Polyneuropathy

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Expression for genes affiliated with Polyneuropathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyneuropathy

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Pathways for genes affiliated with Polyneuropathy

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Compounds for genes affiliated with Polyneuropathy

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1deae459.9TUBB, TTR
2megestrol acetate459.8IFNA2, TTR
3vitamin-e459.7TTR, CNTF, IFNA2
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.5TUBB, NGF, IFNA2
5capsaicin45 2910.5AKR1B1, NGF, GDNF
6levodopa45 1110.4NGF, AKR1B1, GDNF
7epinephrine45 24 1111.4NGF, TTR, AKR1B1, IFNA2
8glycerol45 24 1111.4TUBB, NGF, AKR1B1, TTR
9cocaine45 1110.3GDNF, NGF, CNTF
10methionine459.3TUBB, TTR, IFNA2, CNTF
11valine459.3TUBB, NGF, TTR, IFNA2
12histamine45 29 2411.2NGF, FCGR2B, IFNA2, CNTF
13glutamine459.2AKR1B1, TTR, NGF, TUBB
14dihydrotestosterone45 29 24 1112.1PMP22, NGF, AKR1B1
15rituximab45 51 1111.1FCGR2B, CD59, IFNA2
16fitc459.1CD59, TUBB, FCGR2B
17actinomycin d459.1GDNF, NGF, AKR1B1, CNTF
18azathioprine45 3 51 1112.1NGF, IFNA2, CD59
19aspirin45 51 29 2412.0NGF, TTR, AKR1B1, CD59
20testosterone45 61 24 1112.0AKR1B1, CNTF, TTR, NGF, TUBB
21bromodeoxyuridine459.0CNTF, TUBB, GDNF
22ascorbic acid45 2410.0AKR1B1, IFNA2, PMP22, TTR, CNTF
23norepinephrine45 24 1111.0CNTF, AKR1B1, TTR, GDNF, NGF
24arginine459.0NGF, CNTF, AKR1B1, TTR, PMP22
25cyclosporin a45 29 6110.9AKR1B1, NGF, CD59, TTR
26gaba458.9CNTF, GDNF, PMP22, TUBB
27dopamine45 29 24 1111.9GDNF, NGF, TTR, IFNA2, CNTF
28thymidine45 249.8NGF, TUBB, CNTF, FCGR2B, IFNA2
29creatinine458.8TUBB, GDNF, NGF, TTR, AKR1B1
30vegf458.7NGF, IFNA2, CNTF, AKR1B1, GDNF
31glutamate458.7GDNF, TTR, CNTF, NGF, TUBB
32aspartate458.7PMP22, IFNA2, TTR, GDNF
33lactate458.7AKR1B1, CD59, TTR, TUBB
34inositol458.6FCGR2B, CD59, AKR1B1
35genistein45 29 61 3 24 1113.6CNTF, GDNF, NGF, FCGR2B, AKR1B1, TTR
36forskolin45 51 1110.5PMP22, NGF, TUBB, GDNF, CNTF
37iron45 249.5IFNA2, CD59, GDNF, TTR
38adenylate458.5GDNF, AKR1B1, TTR, NGF, TUBB, CNTF
39retinoic acid45 249.3GDNF, TTR, NGF, PMP22, IFNA2, CNTF
40estrogen458.3AKR1B1, TUBB, FCGR2B, GDNF, TTR, IFNA2
41superoxide45 249.3IFNA2, GDNF, FCGR2B, CNTF, CD59
42ganglioside458.3PMP22, NGF, CD59, CNTF, GDNF
43glucose458.0TTR, IFNA2, CNTF, CD59, GDNF, AKR1B1
44alanine458.0IFNA2, TTR, CNTF, TUBB, NGF, GDNF
45oxygen45 248.9AKR1B1, CD59, GDNF, IFNA2, TUBB
46phosphatidylinositol457.8CD59, GDNF, FCGR2B, CNTF, TUBB, NGF
47cysteine457.8AKR1B1, TTR, NGF, PMP22, TUBB, GDNF
48lipid457.7TUBB, FCGR2B, GDNF, CD59, CNTF, IFNA2
49serine457.5GDNF, TUBB, PMP22, NGF, TTR, FCGR2B
50tyrosine457.4GDNF, TUBB, NGF, IFNA2, CNTF, CD59

GO Terms for genes affiliated with Polyneuropathy

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16Gene Ontology
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Cellular components related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:0432188.8CD59, PMP22
2extracellular regionGO:0055767.9GDNF, NGF, TTR, IFNA2, CD59
3extracellular spaceGO:0056157.5IFNA2, NGF, TTR, AKR1B1, CD59, CNTF

Biological processes related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.6CNTF, IFNA2
2adult locomotory behaviorGO:0083449.5NGF, GDNF
3peripheral nervous system developmentGO:0074229.3NGF, PMP22
4negative regulation of neuron apoptotic processGO:0435249.2CNTF, NGF, GDNF

Molecular functions related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2CNTF, NGF, GDNF

Products for genes affiliated with Polyneuropathy

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Sources for Polyneuropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet