Aliases & Classifications for Polyneuropathy

Summaries for Polyneuropathy

Disease Ontology : 12 A peripheral system disease that is characterized by is damage affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, pins-and-needles, and burning pain.

MalaCards based summary : Polyneuropathy, also known as polyneuropathies, is related to alcoholic neuropathy and charcot-marie-tooth disease, type 1e, and has symptoms including neuralgia An important gene associated with Polyneuropathy is TTR (Transthyretin), and among its related pathways/superpathways are Neural Crest Differentiation and Cell adhesion molecules (CAMs). The drugs Imipramine and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and testes, and related phenotypes are Decreased viability and behavior/neurological

Wikipedia : 71 Polyneuropathy (poly- + neuro- + -pathy) is damage or disease affecting peripheral nerves (peripheral... more...

Related Diseases for Polyneuropathy

Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 544)
id Related Disease Score Top Affiliating Genes
1 alcoholic neuropathy 32.5 CD40LG CD79A
2 charcot-marie-tooth disease, type 1e 29.8 MBP MPZ PMP22
3 chronic inflammatory demyelinating polyneuropathy 12.3
4 polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract 12.1
5 diabetic polyneuropathy 12.1
6 critical illness polyneuropathy 12.1
7 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 12.0
8 polyendocrine-polyneuropathy syndrome 12.0
9 ataxia and polyneuropathy, adult-onset 11.9
10 demyelinating polyneuropathy 11.9
11 subacute inflammatory demyelinating polyneuropathy 11.9
12 paraneoplastic polyneuropathy 11.9
13 chronic polyneuropathy 11.9
14 polyneuropathy due to drug 11.8
15 polyneuropathy associated with igm monoclonal gammapathy with anti-mag 11.8
16 axonal polyneuropathy associated with igg/igm/iga monoclonal gammopathy 11.8
17 amyloidosis, hereditary, transthyretin-related 11.7
18 poems syndrome 11.7
19 idiopathic progressive polyneuropathy 11.7
20 chronic metabolic polyneuropathy 11.7
21 chronic toxic polyneuropathy 11.7
22 aplasia of extensor muscles of fingers, unilateral, with generalized polyneuropathy 11.7
23 familial amyloid polyneuropathy type ii 11.7
24 polyneuropathy mental retardation acromicria premature menopause 11.7
25 neuropathy, inflammatory demyelinating 11.7
26 charcot-marie-tooth disease, x-linked recessive, 5 11.7
27 agenesis of the corpus callosum with peripheral neuropathy 11.7
28 polyneuropathy-intellectual disability-acromicria-premature menopause syndrome 11.6
29 familial amyloid polyneuropathy type 1 11.6
30 juvenile-onset small-fiber polyneuropathy 11.6
31 polyneuropathy in collagen vascular disease 11.6
32 thiamine metabolism dysfunction syndrome 4 11.5
33 guillain-barre syndrome 11.5
34 amyloidosis, finnish type 11.4
35 mitochondrial neurogastrointestinal encephalopathy disease 11.4
36 neuropathy, recurrent, with pressure palsies 11.1
37 diabetic neuropathy 11.0
38 autonomic neuropathy 11.0
39 canomad syndrome 11.0
40 charcot-marie-tooth disease, type 1b 11.0
41 giant axonal neuropathy-1 11.0
42 foot drop 11.0
43 polyradiculoneuropathy 11.0
44 neuropathy, hereditary sensory and autonomic, type ii 11.0
45 charcot-marie-tooth disease, axonal, type 2v 10.9
46 hereditary neuropathy with liability to pressure palsy 10.9
47 lattice corneal dystrophy type ii 10.9
48 lattice corneal dystrophy 10.9
49 familial amyloidosis, finnish type 10.9
50 peroxisome biogenesis disorder 14b 10.8

Graphical network of the top 20 diseases related to Polyneuropathy:



Diseases related to Polyneuropathy

Symptoms & Phenotypes for Polyneuropathy

UMLS symptoms related to Polyneuropathy:


neuralgia

GenomeRNAi Phenotypes related to Polyneuropathy according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.17 CD79A MPZ RBP4
2 Decreased viability GR00381-A-2 9.17 RBP4
3 Decreased viability GR00381-A-3 9.17 CD79A MPZ RBP4

MGI Mouse Phenotypes related to Polyneuropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.23 ABHD12 ACHE AKR1B1 ARSA CNTN1 MAG
2 homeostasis/metabolism MP:0005376 10.22 ABHD12 ACHE AKR1B1 ARSA CD40LG CD59
3 cellular MP:0005384 10.21 CD40LG CD59 CD79A CNTN1 GSN MBP
4 hematopoietic system MP:0005397 10.11 ACHE ARSA CD40LG CD59 CD79A GSN
5 mortality/aging MP:0010768 10.07 PNPLA6 POLG TUBB3 ACHE AKR1B1 CD40LG
6 nervous system MP:0003631 10.03 MAG MBP MPZ NFASC PMP22 PNPLA6
7 hearing/vestibular/ear MP:0005377 9.95 MBP PMP22 POLG ABHD12 ACHE ARSA
8 reproductive system MP:0005389 9.61 ACHE CD40LG CD59 GSN MBP MPZ
9 vision/eye MP:0005391 9.23 ABHD12 ACHE AKR1B1 CNTN1 MBP PMP22

Drugs & Therapeutics for Polyneuropathy

Drugs for Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 311)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imipramine Approved Phase 4 50-49-7 3696
2
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 148553-50-8 5486971
3
Lenalidomide Approved Phase 4,Phase 2 191732-72-6 216326
4 Piracetam Approved Phase 4,Phase 2 7491-74-9
5
Citalopram Approved Phase 4 59729-33-8 2771
6
Cilostazol Approved Phase 4 73963-72-1 2754
7
Capsaicin Approved Phase 4,Phase 2,Phase 3 404-86-4 1548943
8
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Early Phase 1 51-84-3 187
9
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
10
Oxcarbazepine Approved Phase 4 28721-07-5 34312
11
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
12
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
13
Norepinephrine Approved Phase 4,Phase 2 51-41-2 439260
14
Mexiletine Approved Phase 4,Phase 2 31828-71-4 4178
15
Nortriptyline Approved Phase 4 72-69-5 4543
16
alemtuzumab Approved, Investigational Phase 4,Phase 2 216503-57-0
17
Ranolazine Approved, Investigational Phase 4 142387-99-3, 95635-55-5 56959
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
19 Adrenergic Agents Phase 4,Phase 3,Phase 2
20 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
21 Anti-Anxiety Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Anticonvulsants Phase 4,Phase 3,Phase 2,Phase 1
23 Antidepressive Agents Phase 4,Phase 2
24 Antidepressive Agents, Tricyclic Phase 4
25 calcium channel blockers Phase 4,Phase 3,Phase 2,Phase 1
26 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
27 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
28 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2
30 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1
32 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Nootropic Agents Phase 4,Phase 2,Phase 3
34 Protective Agents Phase 4,Phase 2,Phase 3,Early Phase 1
35 Autonomic Agents Phase 4,Phase 3,Phase 2
36 Antioxidants Phase 4,Phase 2,Phase 3,Early Phase 1
37 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
38 Thioctic Acid Phase 4,Phase 2,Phase 3
39 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
40 Vitamin B Complex Phase 4,Phase 2,Phase 3
41 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
42 Angiogenesis Inhibitors Phase 4,Phase 2
43 Angiogenesis Modulating Agents Phase 4,Phase 2
44 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
45 Anti-Infective Agents Phase 4,Phase 3,Phase 2
46 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
47 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
48 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
49 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
50 glucocorticoids Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 320)
id Name Status NCT ID Phase
1 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4
2 Muscular Electrostimulation of the Sedated and Mechanically Ventilated Critically Ill Patient. Analysis of the Effect on Acquired Muscular Weakness and Its Clinical Consequences. Unknown status NCT02033057 Phase 4
3 Evaluation of the Impact of Training on Outcome Measures in Subjects With Painful Diabetic Neuropathy Unknown status NCT01770964 Phase 4
4 Effects of Pregabalin on Mechanical Hyperalgesia Unknown status NCT00310583 Phase 4
5 Levetiracetam for Painful Polyneuropathy Completed NCT00286260 Phase 4
6 Escitalopram as a Treatment for Pain in Polyneuropathy Completed NCT00162968 Phase 4
7 Asian Study on Cilostazol Effectivity in Neuropathies of Diabetes Mellitus Type 2-A Pilot Study in the Philippines Completed NCT01076478 Phase 4
8 A Study to Compare QUTENZA With Pregabalin for the Treatment of Peripheral Neuropathic Pain (PNP) After 8 Weeks of Treatment Completed NCT01713426 Phase 4
9 Alpha Lipoic Acid for Treatment of Diabetic Neuropathy Completed NCT02439879 Phase 4
10 Botulinum Toxin in Peripheral Neuropathic Pain Completed NCT01251211 Phase 4
11 Oxcarbazepine for the Treatment of Chronic Peripheral Neuropathic Pain Completed NCT01302275 Phase 4
12 Lidoderm® (Lidocaine Patch 5%) in Diabetic and Idiopathic Neuropathy Completed NCT00903851 Phase 4
13 Study To Evaluate The Safety And Efficacy Of Lenalidomide For Refractory Cutaneous Lupus Completed NCT01408199 Phase 4
14 Duloxetine in Patients With Diabetic in Peripheral Neuropathic Pain With or Without Co-morbid Major Depressive Disorder Completed NCT00844194 Phase 4
15 Effect of Pulsing Electrical Fields on Lower Extremity Diabetic Neuropathy: A Pilot, Open-Label Study Completed NCT00614341 Phase 4
16 Postoperative Alpha Lipoic Acid in the Carpal Tunnel Syndrome: a Randomized Controlled Trial. Completed NCT01895621 Phase 4
17 Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations Recruiting NCT02260388 Phase 4
18 IVIg for Demyelination in Diabetes Mellitus Recruiting NCT02372149 Phase 4
19 Study of Ranexa in Patients With Coronary Artery Disease and Painful Polyneuropathy Terminated NCT00832572 Phase 4
20 Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin Withdrawn NCT01116531 Phase 4
21 Alemtuzumab in Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD) Withdrawn NCT01757574 Phase 4
22 Lidocaine and Triamcinolone vs Saline Trigger Point Injection for Treatment of Chronic Abdominal Wall Pain Withdrawn NCT02748395 Phase 4
23 Efficacy and Safety Study of Thioctacid Oral Tablets 600mg to Treat Chinese Diabetic Patients With Distal Symmetric Polyneuropathy Unknown status NCT01224353 Phase 2, Phase 3
24 Effects of Benfotiamine on Intraepidermal Nerve Fiber Density (IENFD) Unknown status NCT01868191 Phase 3
25 Treadmill, Stretching and Proprioceptive Exercise (TreSPE) Rehabilitation Program for Charcot−Marie−Tooth Neuropathy Type 1A (CMT1A) Unknown status NCT01289704 Phase 2, Phase 3
26 RIMAG Study: Trial of Rituximab Versus Placebo in Polyneuropathy Associated With Anti-MAG IgM Monoclonal Gammopathy Completed NCT00259974 Phase 3
27 Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Chronic Inflammatory Demyelinating Polyneuropathy. Completed NCT01824251 Phase 3
28 Actovegin® Versus Placebo in Patients With Diabetic Polyneuropathy (AV-007-IM) Completed NCT00483730 Phase 3
29 Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Diabetic Polyneuropathy (Stage 1 or 2) Completed NCT00977483 Phase 3
30 Evaluating the Efficacy and Safety of Oral Ranirestat (40 and 80 mg) in Mild to Moderate Diabetic Sensorimotor Polyneuropathy Completed NCT00927914 Phase 2, Phase 3
31 Study of Efficacy and Safety of Privigen in Subjects With Chronic Inflammatory Demyelinating Polyneuropathy Completed NCT01184846 Phase 3
32 Randomized Open-label Trial to Compare Efficacy and Tolerance of Corticosteroids and IVIg Completed NCT01349270 Phase 3
33 The Effect Of Tafamidis For The Transthyretin Amyloid Polyneuropathy Patients With V30M Or Non-V30M Transthyretin Completed NCT01435655 Phase 3
34 An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid Polyneuropathy Completed NCT00791492 Phase 2, Phase 3
35 Neuropathic Pain Management Completed NCT01263132 Phase 3
36 Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Treatment With Subcutaneous Immunoglobulin (IgPro20) Completed NCT01545076 Phase 3
37 Safety and Efficacy Study of Fx-1006A in Patients With Familial Amyloidosis Completed NCT00409175 Phase 2, Phase 3
38 Safety and Efficacy of AS-3201 in the Treatment of Diabetic Sensorimotor Polyneuropathy Completed NCT00101426 Phase 3
39 Immune Globulin Intravenous (IGIV) For Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Completed NCT00220740 Phase 3
40 Efficacy and Safety Study of Topical Capsaicin in Painful Diabetic Neuropathy Completed NCT00993070 Phase 2, Phase 3
41 Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Completed NCT00328601 Phase 3
42 Phase III Randomized, Double-Blind, Placebo-Controlled Study of 3,4-Diaminopyridine for Demyelinating Polyneuropathy Completed NCT00004939 Phase 3
43 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Immune Globulin for Chronic Inflammatory Demyelinating Polyneuropathy Completed NCT00004772 Phase 3
44 The Effect of Diflunisal on Familial Amyloidosis Completed NCT00294671 Phase 2, Phase 3
45 Evaluate The Efficacy and Safety Of Pregabalin In Prevention, Reduction of Oxaliplatin-Induced Painful Neuropathy Completed NCT01450163 Phase 3
46 Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy Completed NCT00064623 Phase 3
47 Phase III Multicenter Double Blind Controlled Trial of Human Immune Globulin Therapy in Previously Untreated Patients With Chronic Inflammatory Demyelinating Neuropathy Completed NCT00004286 Phase 3
48 TempTouch IR Thermometry & Diabetic Patient Self-Care Completed NCT00289497 Phase 2, Phase 3
49 A Safety and Efficacy Study for Tapentadol (CG5503) Extended Release for Patients With Painful Diabetic Peripheral Neuropathy Completed NCT00455520 Phase 3
50 A Study to Evaluate the Efficacy, Safety, and Tolerability of Tapentadol ER Compared With Placebo in Patients With Chronic, Painful Diabetic Peripheral Neuropathy Completed NCT01041859 Phase 3

Search NIH Clinical Center for Polyneuropathy

Cochrane evidence based reviews: polyneuropathies

Genetic Tests for Polyneuropathy

Genetic tests related to Polyneuropathy:

id Genetic test Affiliating Genes
1 Polyneuropathy 29

Anatomical Context for Polyneuropathy

MalaCards organs/tissues related to Polyneuropathy:

39
Liver, Skin, Testes, Heart, T Cells, Bone, Spinal Cord

Publications for Polyneuropathy

Articles related to Polyneuropathy:

(show top 50) (show all 2069)
id Title Authors Year
1
De novo p.T362R mutation in MORC2 causes early onset cerebellar ataxia, axonal polyneuropathy and nocturnal hypoventilation. ( 28402445 )
2017
2
Subcutaneous immunoglobulin as first-line therapy in treatment-naive patients with chronic inflammatory demyelinating polyneuropathy: randomized controlled trial study. ( 28000311 )
2017
3
An Isolated Case of Late-onset Amyloidogenic Transthyretin Type Familial Amyloid Polyneuropathy Associated with a Mutant Transthyretin Substituting Methionine for Valine at Position 30 Showing Latent Progressive Cardiac Involvement Confirmed by Serial Annual Electrocardiograms. ( 28090046 )
2017
4
Initial development and validation of a patient-reported symptom survey for small-fiber polyneuropathy. ( 28063957 )
2017
5
Gastroduodenal Burkitt Lymphoma Presenting as Demyelinating Polyneuropathy. ( 28532696 )
2017
6
Sonographic Findings of Polyneuropathy Associated With Cerebrotendinous Xanthomatosis: A Case Report. ( 28503466 )
2017
7
Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with antineurofascin-155 and anticontactin-1 antibodies. ( 28073817 )
2017
8
In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells. ( 28051995 )
2017
9
Demyelinating polyneuropathy in a case of anti-LGI1 encephalitis. ( 28073143 )
2017
10
Severe vincristine-induced polyneuropathy in a teenager with anaplastic medulloblastoma and undiagnosed Charcot-Marie-Tooth disease. ( 28438772 )
2017
11
Hereditary Sensory Polyneuropathy, Pain Insensitivity and Global Developmental Delay due to Novel Mutation in PRDM12 Gene. ( 28050684 )
2017
12
Oxytocin provides protection against diabetic polyneuropathy in rats. ( 27881053 )
2017
13
Poster 200 Demyelinating Polyneuropathy Post-Operatively in a Patient with Squamous Cell Carcinoma of the Tongue: A Case Report. ( 27672963 )
2016
14
Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells. ( 27584576 )
2016
15
Postural tremor and chronic inflammatory demyelinating polyneuropathy. ( 27421831 )
2016
16
Neurofascin-155 IgG4 in chronic inflammatory demyelinating polyneuropathy. ( 26843559 )
2016
17
Validity of the shuttle walk test as a functional assessment of walking ability in individuals with polyneuropathy. ( 27599252 )
2016
18
Study of Autophagy and Microangiopathy in Sural Nerves of Patients with Chronic Idiopathic Axonal Polyneuropathy. ( 27662650 )
2016
19
Leprosy as a Cause of Distal Symmetric Polyneuropathy--Reply. ( 27187311 )
2016
20
Cochlear implantation in chronic demyelinating inflammatory polyneuropathy. ( 28010677 )
2016
21
Improvement of hemoglobin levels after a switch from intravenous to subcutaneous administration of immunoglobulin in chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy. ( 27401495 )
2016
22
The Facilitative Effect of Transcranial Direct Current Stimulation on Visuospatial Working Memory in Patients with Diabetic Polyneuropathy: A Pre-post Sham-Controlled Study. ( 27733822 )
2016
23
Systemic Lupus Erythematosus With Acute Inflammatory Demyelinating Polyneuropathy: A Case Report and Review of the Literature. ( 27298667 )
2016
24
Perioperative Predictors of Survival After Liver Transplantation for Familial Amyloid Polyneuropathy in a Portuguese Center. ( 27569952 )
2016
25
Knowing what's right: Which analgesic is recommended for a patient suffering from demyelinating polyneuropathy and scheduled for rotator-cuff repair? ( 27338205 )
2016
26
Corneal confocal microscopy in chronic inflammatory demyelinating polyneuropathy. ( 26900579 )
2016
27
Idiopathic CD4 lymphocytopenia with sensorimotor polyneuropathy. ( 27570393 )
2016
28
Kennedy Disease Misdiagnosed as Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes (POEMS) Syndrome: A Case Report. ( 26618536 )
2016
29
Dysautonomic polyneuropathy as a variant of chronic inflammatory "demyelinating" polyneuropathy? ( 27379500 )
2016
30
Neuromuscular Ultrasound in the Assessment of Polyneuropathies and Motor Neuron Disease. ( 27035248 )
2016
31
Erythromelalgia-like presentation of chronic acquired demyelinating polyneuropathy in a setting of past alcohol abuse. ( 26804376 )
2016
32
Challenges in pediatric chronic inflammatory demyelinating polyneuropathy. ( 27793469 )
2016
33
Acute-onset chronic inflammatory demyelinating polyneuropathy in hantavirus and hepatitis B virus coinfection: A case report. ( 27930572 )
2016
34
Is Stem Cell Transplantation Ready for Prime Time in Diabetic Polyneuropathy? ( 27485630 )
2016
35
Poster 487 Chronic Inflammatory Demyelinating Polyneuropathy or Something Else?: A Case Report. ( 27673228 )
2016
36
Comparative Clustering of Plantar Pressure Distributions in Diabetics with Polyneuropathy May Be Applied to Reveal Inappropriate Biomechanical Stress. ( 27529421 )
2016
37
Clinical-pathologic correlations in VGKC-subtyped autoimmune painful polyneuropathy. ( 27511450 )
2016
38
Comparative analysis of the effects combined physical procedures and alpha-lipoic acid on the electroneurographic parameters of patients with distal sensorimotor diabetic polyneuropathy. ( 27065527 )
2016
39
Whole-body MR neurography: Prospective feasibility study in polyneuropathy and Charcot-Marie-Tooth disease. ( 27126998 )
2016
40
The dilemma of diabetes in chronic inflammatory demyelinating polyneuropathy. ( 27389526 )
2016
41
Sonographic features of peripheral nerves at multiple sites in patients with diabetic polyneuropathy. ( 26782023 )
2016
42
Paraneoplastic Progressive Vasculopathy as the Presenting Manifestation of Polyneuropathy, Organomegaly, Endocrinopathy or Edema, M-Spike, and Skin Manifestations: A Case Report. ( 27177922 )
2016
43
Cardiovascular Autonomic Dysfunction Predicts Diabetic Foot Ulcers in Patients With Type 2 Diabetes Without Diabetic Polyneuropathy. ( 27015188 )
2016
44
Familial Amyloid Polyneuropathy Type IV (FINNISH) with Rapid Clinical Progression in an Iranian Woman: A Case Report. ( 27217609 )
2016
45
Recovery After Critical Illness Polyneuropathy in a Patient With Orthotopic Liver Transplantation: A Case Report. ( 27932182 )
2016
46
Critical illness polyneuropathy and myopathy 20A years later. No man's land? No, it is our land! ( 27502507 )
2016
47
Evaluation of Patients with Refractory Chronic Inflammatory Demyelinating Polyneuropathy. ( 27463215 )
2016
48
Physical activity and albuminuria were associated with painful diabetic polyneuropathy in type 2 diabetes in an ethnic Chinese population. ( 27592367 )
2016
49
Intrathecal Dexmedetomidine for Anaesthetic Management of a Patient with Chronic Inflammatory Demyelinating Polyneuropathy. ( 27790558 )
2016
50
Anti-ganglioside antibodies in Guillain-BarrAc syndrome and chronic inflammatory demyelinating polyneuropathy in Chinese patients. ( 27464289 )
2016

Variations for Polyneuropathy

ClinVar genetic disease variations for Polyneuropathy:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GDAP1 NM_018972.2(GDAP1): c.715C> T (p.Leu239Phe) single nucleotide variant Pathogenic rs104894080 GRCh37 Chromosome 8, 75276240: 75276240

Expression for Polyneuropathy

Search GEO for disease gene expression data for Polyneuropathy.

Pathways for Polyneuropathy

Pathways related to Polyneuropathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.34 MBP MPZ PMP22
2 11.18 CD40LG CNTN1 MAG MPZ NFASC
3 9.86 MAG MBP

GO Terms for Polyneuropathy

Cellular components related to Polyneuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 9.88 GSN MBP POLG RBP4 TTR
2 extracellular space GO:0005615 9.81 ACHE AKR1B1 ARSA CD40LG CD59 GSN
3 paranode region of axon GO:0033270 9.46 MAG NFASC
4 Schmidt-Lanterman incisure GO:0043220 9.43 AKR1B1 MAG
5 paranodal junction GO:0033010 9.32 AKR1B1 NFASC
6 Schwann cell microvillus GO:0097454 9.26 AKR1B1 NFASC
7 compact myelin GO:0043218 9.13 CD59 MAG PMP22
8 myelin sheath GO:0043209 9.1 CNTN1 GSN MAG MBP MPZ NFASC
9 plasma membrane GO:0005886 10.18 ABHD12 ACHE ARSA CD40LG CD59 CD79A
10 extracellular exosome GO:0070062 10.1 AKR1B1 ARSA CD59 CNTN1 GSN NFASC

Biological processes related to Polyneuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.77 ARSA CD59 GSN NFASC TTR
2 B cell differentiation GO:0030183 9.5 CD40LG CD79A IFNA2
3 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.26 MAG MPZ
4 glycerophospholipid catabolic process GO:0046475 9.16 ABHD12 PNPLA6
5 B cell proliferation GO:0042100 9.13 CD40LG CD79A IFNA2
6 myelination GO:0042552 8.92 MBP MPZ NFASC PMP22

Sources for Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....