MCID: PLY019
MIFTS: 64

Polyneuropathy malady

Neuronal diseases category

Summaries for Polyneuropathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Polyneuropathy or symmetrical polyneuropathy (poly- + neuro- + -pathy) is damage (peripheral neuropathy)... more...

MalaCards: Polyneuropathy, also known as polyneuropathy, unspecified, is related to diabetic polyneuropathy and neuropathy. An important gene associated with Polyneuropathy is TTR (transthyretin), and among its related pathways are Influenza A and Cell adhesion molecules (CAMs). The compounds cysteine and lipid have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and testes, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Polyneuropathy

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Related Diseases for Polyneuropathy

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17GeneCards, 18GeneDecks
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Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 463)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic polyneuropathy31.5AKR1B1, NGF
2neuropathy30.9MPZ, TTR, AKR1B1, NGF, PMP22, MAG
3myopathy30.7GSN, PMP22, MPZ, NGF
4amyloidosis30.6TTR, GSN
5diabetes mellitus30.6AKR1B1, TNF, PMP22, AIRE, NGF
6diabetic neuropathy30.5NGF, GDNF, CNTF, PMP22, AKR1B1, MPZ
7myeloma30.5CD28, CNTF, MAG, IFNA2
8hepatitis30.4TTR, AIRE, IFNA2
9leukemia30.3GSN, GDNF, NGF, CNTF, TTR, IFNA2
10familial transthyretin amyloidosis30.3GSN, TTR
11hepatitis c30.3IFNA2, TNF, CD28
12myasthenia gravis30.2CD28, AIRE, MAG
13guillain-barre syndrome30.2MPZ, TUBB, PMP22
14multiple sclerosis30.1TNF, MPZ, MAG, TUBB, NGF, CD1D
15melanoma30.1IFNA2, GSN, TNF, AKR1B1, MAG, CD28
16charcot-marie-tooth disease30.1PMP22, MPZ
17peritonitis30.1TNF
18autonomic neuropathy30.1TTR, NGF, AKR1B1
19lupus erythematosus30.1FCGR2B
20tooth disease30.1PMP22, MPZ
21amyotrophic lateral sclerosis30.0CNTF, MAG, GDNF, NGF
22hepatitis b30.0IFNA2, AKR1B1
23pneumonia30.0TNF
24malaria29.9CNTF, TNF
25dementia29.9NGF
26cerebral amyloid angiopathy29.9TTR
27vasculitis29.9IFNA2, TNF
28diabetic autonomic neuropathy29.9AKR1B1, NGF
29parkinson's disease29.9NGF, GDNF
30ischemia29.8AKR1B1, AIF1, CNTF, GDNF
31arthritis29.8FCGR2B, TNF
32motor neuron disease29.8GDNF, CNTF
33breast cancer29.8TUBB, GSN
34finnish type amyloidosis29.8GSN, TTR
35chronic inflammatory demyelinating polyradiculoneuropathy29.8MPZ, PMP22
36encephalitis29.8CNTF
37hereditary neuropathy with liability to pressure palsies29.8PMP22
38rheumatoid arthritis29.6CNTF, FCGR2B, CD1D, CD28, TNF
39neuritis29.6PMP22, AIF1, MPZ
40asthma29.6GSN, CD28, TNF, NGF
41myocardial infarction29.6AKR1B1
42meningitis29.6GDNF
43sarcoidosis29.6CD28, TNF
44charcot-marie-tooth disease type 4e29.6MPZ, PMP22
45neuroblastoma29.6NGF
46diabetic retinopathy29.6AKR1B1
47psoriasis29.6NGF, TNF, CD28
48deficiency anemia29.6TTR, IFNA2
49herpes simplex29.6GDNF
50optic neuritis29.6MAG, MPZ

Graphical network of the top 20 diseases related to Polyneuropathy:



Diseases related to polyneuropathy

Clinical Features for Polyneuropathy

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Drugs & Therapeutics for Polyneuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Polyneuropathy

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Anatomical Context for Polyneuropathy

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32MalaCards
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MalaCards organs/tissues related to Polyneuropathy:

32
Liver, Skin, Testes, Bone, Heart, T cells, Endothelial, Spinal cord, Kidney, B cells, Bone marrow, Pancreas, Brain, Myeloid, Breast, Lung, Prostate, Nk cells, Thalamus, Colon, Thyroid, Eye, Lymph node, Dorsal root ganglion

Animal Models for Polyneuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polyneuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.2GSN, PMP22, TNF, MPZ, AIRE, MAG
2MP:000538611.1PMP22, TNF, AKR1B1, MPZ, AIRE, MAG
3MP:000537611.1CNTF, AIRE, MPZ, AKR1B1, TNF, NGF
4MP:000539711.0TNF, MPZ, AIRE, CNTF, CD1D, CD28
5MP:000538710.9CNTF, AIRE, MPZ, TNF, CD1D, CD28
6MP:000538410.9AIRE, MPZ, TNF, PMP22, CNTF, CD1D
7MP:001076810.8PMP22, TNF, AKR1B1, MPZ, AIRE, NGF
8MP:000539110.7TNF, AKR1B1, AIRE, NGF, CD28, ABHD12
9MP:000537910.6GSN, FCGR2B, GDNF, TNF
10MP:000538510.4TNF, NGF, CD1D, CD28, GDNF, CLDN5

Publications for Polyneuropathy

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50PubMed
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Articles related to Polyneuropathy:

(show top 50)    (show all 1736)
idTitleAuthorsYear
1
Distal acquired demyelinating symmetric polyneuropathy progressing to classic chronic inflammatory demyelinating polyneuropathy and response to fludarabine and cyclophosphamide. (23168526)
2013
2
Severe hyponatremia as the initial sign preceding guillain-barrAc syndrome, an acute inflammatory demyelinating polyneuropathy: a case report. (23476842)
2013
3
Diaphragmatic weakness with progressive sensory and motor polyneuropathy: case report of a neonatal IGHMBP2-related neuropathy. (22791546)
2013
4
Lower urinary tract dysfunction in critical illness polyneuropathy. (23949055)
2013
5
Subacute inflammatory demyelinating polyneuropathy disclosed by massive nerve root enhancement in CMT1A. (22173780)
2012
6
Brucellosis manifesting as chronic inflammatory demyelinating polyneuropathy. (22728867)
2012
7
Carpal tunnel syndrome as an initial manifestation in a case of transthyretin-related familial amyloid polyneuropathy with a novel A120T mutation. (22209138)
2012
8
Coexistence of transthyretin familial amyloid polyneuropathy and hereditary neuropathy with liability to pressure palsy. (22520972)
2012
9
Zinc toxicity: denture adhesives, bone marrow failure and polyneuropathy. (22375440)
2012
10
Familial amyloidotic polyneuropathy and transthyretin. (23225017)
2012
11
Temporary auxiliary partial orthotopic liver transplantation using a small graft for familial amyloid polyneuropathy. (22500969)
2012
12
Microscopic polyangiitis presented with polyneuropathy of lower extremities and ANCA-associated glomerulonephritis: case report. (22364305)
2012
13
Effects of an exercise training program in physical condition after liver transplantation in familial amyloidotic polyneuropathy: a case report. (21335200)
2011
14
Salmonella typhi infection complicated by rhabdomyolysis, pancreatitis and polyneuropathy. (21999858)
2011
15
Microvascular perfusion abnormalities of the Thalamus in painful but not painless diabetic polyneuropathy: a clue to the pathogenesis of pain in type 1 diabetes. (21282344)
2011
16
How sensitive is the case definition for diabetic sensorimotor polyneuropathy to the use of different symptoms, signs, and nerve conduction parameters in type 1 diabetes? (21227527)
2011
17
Chronic inflammatory demyelinating polyneuropathy after treatment with pegylated interferon alpha 2b in a patient with HIV/HCV coinfection: case report]. (20305976)
2010
18
Critical illness polyneuropathy: a rare but serious adverse event in pediatric oncology. (19760771)
2010
19
Electrophysiology in chronic inflammatory demyelinating polyneuropathy with IGIV. (19260050)
2009
20
Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany). (19131463)
2009
21
Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report. (19055816)
2008
22
Acute inflammatory demyelinating polyneuropathy and a unilateral babinski/plantar reflex. (20975794)
2008
23
Efficacy of autologous peripheral blood stem cell transplantation in POEMS syndrome with polyneuropathy. (17268130)
2007
24
Feasibility and cost efficiency of a diagnostic guideline for chronic polyneuropathy: a prospective implementation study. (16484653)
2006
25
Psychological aspects of pre-symptomatic testing for Machado-Joseph disease and familial amyloid polyneuropathy type I. (16630162)
2006
26
Visual evoked potentials and diabetic polyneuropathy. (17122936)
2006
27
Treatment of diabetic polyneuropathy with alpha-lipoic acid is evidence based. (15529620)
2004
28
New insights into diabetic polyneuropathy. (12966130)
2003
29
"Sporadic" familial amyloidotic polyneuropathy in a German patient with B cell lymphocytic leukaemia. (12082059)
2002
30
Effects of sulbutiamine on diabetic polyneuropathy: an open randomised controlled study in type 2 diabetics. (22969314)
2002
31
Distribution patterns of demyelination correlate with clinical profiles in chronic inflammatory demyelinating polyneuropathy. (11784822)
2002
32
A case of polyneuropathy associated with increased levels of vascular endotherial growth factor (VEGF) insera]. (11993185)
2001
33
Vitreous amyloidosis after liver transplantation in patients with familial amyloid polyneuropathy: ocular synthesis of mutant transthyretin. (11132095)
2000
34
Type I interferons and chronic inflammatory demyelinating polyneuropathy: treatment or cause? (10679706)
2000
35
Sequential (domino) transplantation of the liver in a transthyretin-50 familial amyloid polyneuropathy. Special reference to cardiological diagnosis and complications. (10664115)
2000
36
Risk factors for progression of distal symmetric polyneuropathy in type 1 diabetes mellitus. Sorbinil Retinopathy Trial Research Group. (10588075)
1999
37
Prednisone and plasma exchange improve suppressor cell function in chronic inflammatory demyelinating polyneuropathy. (10229130)
1999
38
Acute and chronic neuropathies: new aspects of Guillain-BarrAc syndrome and chronic inflammatory demyelinating polyneuropathy, an overview and an update. (9872432)
1998
39
Diagnostic value of sural nerve biopsy in chronic inflammatory demyelinating polyneuropathy. (9436733)
1998
40
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
41
Chronic inflammatory demyelinating polyneuropathy associated with carcinoma. (8708651)
1996
42
Tendon-reflex testing in chronic demyelinating polyneuropathy. (8114782)
1994
43
Susceptibility to demyelinating polyneuropathy in plasma cell dyscrasia may be influenced by amino acid position 9 of the HLA-DR beta chain. (7681445)
1993
44
A novel transthyretin mutation associated with familial amyloidotic polyneuropathy. (1734866)
1992
45
Peripheral polyneuropathy during treatment with alpha-2 interferon. (1965833)
1990
46
Diagnosis of diabetic polyneuropathy. Correlation between clinical and instrumental findings and assessment of simple diagnostic criteria. (3225169)
1988
47
High-dose intravenous gammaglobulin for chronic inflammatory demyelinating polyneuropathy. (3119516)
1987
48
Brainstem encephalitis or the Miller Fisher syndrome--a variant of acute idiopathic polyneuropathy. Case reports. (6648744)
1983
49
Vasodilation induced by transcutaneous nerve stimulation in peripheral ischemia (Raynaud's phenomenon and diabetic polyneuropathy). (6982164)
1982
50
Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes: the POEMS syndrome. (7086810)
1982

Genetic Variations for Polyneuropathy

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Expression for genes affiliated with Polyneuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyneuropathy

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Pathways for genes affiliated with Polyneuropathy

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29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Polyneuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6FCGR2B, CD28, TNF, IFNA2
210.6MPZ, MAG, CD28, CLDN5
310.6GDNF, MAG, AIF1, TNF
4
Hide members
10.5NGF, MAG

Compounds for genes affiliated with Polyneuropathy

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44Novoseek, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank, 49PharmGKB
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Compounds related to Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1cysteine4411.3PMP22, TUBB, IFNA2, AKR1B1, MPZ, MAG
2lipid4411.3TUBB, IFNA2, TNF, MPZ, MAG, CNTF
3tyrosine4411.3TUBB, IFNA2, MPZ, AIRE, MAG, CNTF
4retinoic acid44 2412.3AIF1, TNF, IFNA2, PMP22, CNTF, NGF
5alanine4411.2TUBB, IFNA2, AKR1B1, MAG, CNTF, NGF
6serine4411.2FCGR2B, PMP22, TUBB, TNF, AKR1B1, MPZ
7genistein44 28 59 2 11 2416.2TNF, AKR1B1, CNTF, NGF, CD28, GDNF
8calcium44 49 11 2414.2CNTF, MAG, AIF1, TUBB, NGF, CD28
9aspartate4411.2PMP22, IFNA2, MPZ, MAG, GDNF, TTR
10adenylate4411.2TUBB, AKR1B1, CNTF, NGF, GDNF, TTR
11thymidine44 2412.2TUBB, IFNA2, TNF, MAG, CNTF, NGF
12ganglioside4411.1PMP22, MPZ, MAG, CNTF, NGF, GDNF
13ascorbic acid44 2412.1PMP22, IFNA2, AKR1B1, MAG, CNTF, TTR
14methionine4411.1TUBB, IFNA2, MPZ, CNTF, TTR, GSN
15phosphatidylinositol4411.1TUBB, CNTF, NGF, CD28, GDNF, FCGR2B
16dopamine44 28 11 2414.1IFNA2, CNTF, NGF, GDNF, TTR, GSN
17superoxide44 2412.1IFNA2, TNF, CNTF, GDNF, FCGR2B, GSN
18dihydrotestosterone44 28 11 2414.1GSN, NGF, MPZ, AKR1B1, PMP22
19bromodeoxyuridine4411.1TUBB, MPZ, AIF1, CNTF, GDNF
20creatinine4411.1AKR1B1, MPZ, NGF, GDNF, TTR
21testosterone44 59 11 2414.0TUBB, AKR1B1, CNTF, NGF, TTR, GSN
22phosphotyrosine4411.0TUBB, MAG, NGF, CD28, GSN
23histamine44 28 2413.0FCGR2B, NGF, CNTF, TNF, IFNA2
24rituximab44 49 1113.0IFNA2, TNF, MAG, FCGR2B
25oxygen44 2412.0TNF, AKR1B1, CD28, GDNF, GSN
26ly2940024411.0GDNF, CD28, NGF, CNTF, TNF
27wortmannin4411.0CNTF, NGF, CD28, GDNF, GSN
28actinomycin d4411.0GDNF, NGF, CNTF, AKR1B1, TNF
29forskolin44 49 1113.0GDNF, NGF, CNTF, TUBB, PMP22
30glutamate4411.0GSN, GDNF, CNTF
31norepinephrine44 11 2413.0CNTF, GDNF, TTR
32vegf4410.9IFNA2, TNF, AKR1B1, CNTF, NGF, GDNF
33arginine4410.9PMP22, AKR1B1, MPZ, CNTF, NGF, TTR
34cyclosporin a44 28 5912.9AKR1B1, NGF, CD28, TTR
353-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4410.9TUBB, IFNA2, NGF
36valine4410.9TTR, NGF, IFNA2, TUBB
37etanercept44 49 1112.9IFNA2, TNF, FCGR2B
38ceramide4410.9TNF, NGF, CD1D, CD28
39alpha lipoic acid4410.9NGF, AKR1B1, TNF
40glycerol44 11 2412.9TUBB, AKR1B1, NGF, TTR
41threonine4410.9TUBB, MAG, CNTF, NGF, CD28, TTR
42glycolipid4410.8CD1D, MAG, MPZ
43ivig4410.8TNF, MAG, FCGR2B
44capsaicin44 2811.7GDNF, NGF, AKR1B1
45melphalan44 1111.7TTR, TNF, IFNA2
46gaba4410.7PMP22, TUBB, CNTF, GDNF
47neopterin4410.6TTR, TNF, IFNA2
48indomethacin44 59 28 1113.6NGF, AKR1B1
49epinephrine44 11 2412.5IFNA2, AKR1B1, NGF, TTR
50cyclic amp44 2411.3GDNF, CD28, NGF, CNTF, MAG

GO Terms for genes affiliated with Polyneuropathy

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16Gene Ontology
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Cellular components related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8TNF, AKR1B1, CNTF, NGF, DHH, TTR
2phagocytic cupGO:00189110.5TNF, AIF1
3paranode region of axonGO:03327010.5CLDN5, MAG
4plasma membraneGO:00588610.5PMP22, TUBB, TNF, MPZ, AIRE, MAG
5Schmidt-Lanterman incisureGO:04322010.4MAG, CLDN5

Biological processes related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1humoral immune responseGO:00695910.6CD28, AIRE, TNF
2apoptotic signaling pathwayGO:09719010.6CD28, NGF, TNF
3positive regulation of T cell proliferationGO:04210210.6CD28, CD1D, AIF1
4inflammatory responseGO:00695410.5IFNA2, TNF, AIF1, NGF
5negative regulation of neuron apoptotic processGO:04352410.3CNTF, NGF, GDNF

Molecular functions related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.6TTR, CLDN5, CD28, AIRE, TNF

Products for genes affiliated with Polyneuropathy

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  • Antibodies
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Sources for Polyneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet