Polyneuropathy malady

Wikipedia: Polyneuropathy is a neurological disorder that occurs when many nerves throughout the body malfunction...⁴⁴ more...

MalaCards: Polyneuropathy, also known as polyneuropathy, unspecified (disorder), is related to demyelinating polyneuropathy and chronic inflammatory demyelinating polyneuropathy. An important gene associated with Polyneuropathy is TTR (transthyretin), and among its related pathways are Doxorubicin Pathway, Pharmacokinetics and Cell adhesion molecules (CAMs). The compounds nadph and glucose have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and heart, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Aliases & Descriptions:

polyneuropathy 6 8 32 43 polyneuropathy, unspecified (disorder) 6 polyneuropathy unspecified (disorder) 6

polyneuropathy unspecified 6 polyneuropathy (disorder) 6

Diseases related to polyneuropathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1033)

id	Related Disease	Score	Top Affiliating Genes
1	demyelinating polyneuropathy	35.7	CNTF, CNTN2, CLDN5, FYB, CD28, CD40LG
2	chronic inflammatory demyelinating polyneuropathy	35.6	CNTF, CLDN5, FYB, CD28, CD1D, FCGR2B
3	diabetic polyneuropathy	34.7	CNTF, VEGFA, BMP6, LIF, PARP1, GSTM1
4	transthyretin amyloidosis	32.1	RBP4, CLU, TTR
5	lattice corneal dystrophy type ii	30.8	GSN, APOE, TTR
6	hepatitis	30.5	RBP4, GPT, IFNA1, IFNA2, ALB, HLA-DRB1
7	familial transthyretin amyloidosis	30.4	GSN, APOA1, TTR
8	poems syndrome	30.0	VEGFA, IL1B, IL6, ALB, TNF, CRP
9	guillain-barre syndrome	29.8	MPZ, CD79A, CD40LG, CD1E, CD1D, MMP9
10	hepatitis c	29.8	CD28, CD40LG, IL10, GPT, IFNA1, IFNA2
11	paraproteinemia	29.5	VEGFA, CD79A, IL6, MAG
12	carpal tunnel syndrome	28.5	VEGFA, B2M, INS, IL1B, IL6, APCS
13	tooth disease	28.4	MPZ, GJB1, EGR2, PMP22
14	hereditary amyloidosis	28.3	GSN, APOA1, TTR
15	hereditary neuropathy with liability to pressure palsy	28.3	MPZ, GJB1, SH3TC2, PMP22
16	polyradiculoneuropathy	27.9	MPZ, CD40LG, MBP, ALB, HLA-DRB1, PMP22
17	type 1 diabetes mellitus	27.8	RBP4, SERPINA7, SCT, B2M, CFB, CD79A
18	diabetic neuropathy	27.7	CNTF, MPZ, INS, AKR1B1, NTF3, NGF
19	motor neuron disease	27.4	CNTF, VEGFA, LIF, INS, GSTM1, GSTT1
20	paralysis	27.1	CNTF, MPZ, INS, GSN, IL10, IL1B
21	syncope	27.1	NOS3, ACE, ACHE, AGT, TTR, DBH
22	charcot-marie-tooth disease	27.1	CNTF, KIF1B, MPZ, MFN2, MBP, MAG
23	waldenstrom macroglobulinemia	27.1	VEGFA, PARP1, CD40LG, CD52, IL10, IL1B
24	cerebral amyloid angiopathy	27.0	MMP9, GSN, IL6, APOE, APP, MBP
25	polyarteritis nodosa	27.0	CD40LG, IL6, GPT, IFNA1, IFNA2, CRP
26	alcoholism	26.9	SCT, ARSA, GPT, ALDH2, COMT, NGF
27	macroglobulinemia	26.6	VEGFA, PARP1, B2M, CD79A, CD40LG, CD52
28	candidiasis	26.6	B2M, CD79A, CD4, CD40LG, INS, IL10
29	myoclonus	26.5	INS, MAG, IFNA2, AMPH, POLG, AAAS
30	amyloidosis	26.4	RBP4, CLU, B2M, CD79A, CD40LG, MMP9
31	cryoglobulinemia	26.4	BMP6, CD79A, CD40LG, IL10, IL1B, GPT
32	ataxia	24.7	PARP1, PARK7, MT-TL1, MPZ, CD28, CD79A
33	neuropathy	24.5	CNTF, KIF1B, VEGFA, LIF, CLDN5, PARP1
34	chronic myeloid leukemia	23.9	PIK3R5, VEGFA, BMP6, PARP1, CD52, GSTM1
35	t-cell leukemia	23.8	CNTN2, VEGFA, BMP6, LIF, PARP1, B2M
36	neurodegeneration	23.4	CNTF, VEGFA, BMP6, LIF, BLVRB, CLU
37	twinning	22.6	RBP4, VEGFA, LIF, S100A8, S100A9, B2M
38	myopathy	22.0	CLU, MT-TL1, MPZ, CD28, CD79A, CD4
39	chronic lymphocytic leukemia	21.6	VEGFA, BMP6, PARP1, B2M, CD28, CD79A
40	lymphocytic leukemia	21.4	CNTN2, VEGFA, BMP6, PARP1, B2M, CD28
41	diabetes mellitus	21.0	PIK3R5, RBP4, SERPINA7, VEGFA, LPO, BMP6
42	myeloid leukemia	20.9	PIK3R5, VEGFA, BMP6, LIF, PARP1, B2M
43	multiple sclerosis	20.8	CNTF, CNTN2, KIF1B, VEGFA, BMP6, LIF
44	hyperglycemia	20.4	VEGFA, BMP6, PARP1, SCT, S100A8, B2M
45	blindness	19.9	CNTF, RBP4, SERPINA7, VEGFA, LIF, CLU
46	cerebritis	19.8	CNTF, CNTN2, RBP4, VEGFA, BMP6, LIF
47	leukemia	19.0	PIK3R5, CNTF, CNTN2, RBP4, VEGFA, LPO
48	neuronitis	18.6	CNTF, CNTN2, KIF1B, VEGFA, BMP6, LIF
49	melanoma	18.1	PIK3R5, CNTF, VEGFA, BMP6, LIF, CLU
50	retinitis	18.1	CNTF, RBP4, VEGFA, BMP6, LIF, BLVRB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to polyneuropathy:

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MGI Mouse Phenotypes related to polyneuropathy:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.6	PEX7, DBH, DHH, NF2, CTLA4, DDX4
2	hematopoietic system phenotype	MP:0005397	10.6	CNTF, FYB, CD28, CD1D, ARSA, GSN
3	respiratory system phenotype	MP:0005388	10.2	NTF3, NOS1, NF2, ACHE, PRX, GLRX
4	other phenotype	MP:0005395	9.7	NOS1, NOS2, NOS3, DHH, SOD2, CSF1
5	embryogenesis phenotype	MP:0005380	9.6	NF2, EGR2, POLG, PORCN, SLC25A19, COMT
6	integument phenotype	MP:0010771	9.6	NGF, EGR2, AHSP, DBH, PRX, CSF1
7	hearing/vestibular/ear phenotype	MP:0005377	9.3	EGR2, ACHE, SOD1, SOD2, CSF1, POLG
8	renal/urinary system phenotype	MP:0005367	9.2	NF2, C1QA, AGT, SOD2, SLC25A19, GAS6
9	liver/biliary system phenotype	MP:0005370	8.7	CD1D, FKBP1A, INS, FCGR2B, IL6, APOA1
10	no phenotypic analysis	MP:0003012	8.6	POLG, AGER, ACHE, EGR2, SST, TP53
11	tumorigenesis	MP:0002006	8.3	TNF, PTGDS, NOS2, NF2, NDRG1, ACE
12	adipose tissue phenotype	MP:0005375	8.2	NOS2, NOS3, ACE, ACHE, AGT, SOD2
13	digestive/alimentary phenotype	MP:0005381	8.2	NOS2, NOS1, PLAT, CTLA4, NOS3, DHH
14	vision/eye phenotype	MP:0005391	8.2	TNF, GAS6, PTPN13, NTF3, PLAT, NOS1
15	reproductive system phenotype	MP:0005389	8.1	RBP4, VEGFA, LIF, B2M, MPZ, MMP9
16	skeleton phenotype	MP:0005390	7.9	PLAT, NOS1, NF2, NFKB1, SH3TC2, SOD3
17	normal phenotype	MP:0002873	7.5	C1orf192, C1QA, NFKB1, NOS1, NTF3, CTLA4
18	nervous system phenotype	MP:0003631	7.3	CNTF, CNTN2, KIF1B, LIF, PARP1, SCT
19	muscle phenotype	MP:0005369	7.0	KIF1B, RBP4, VEGFA, LIF, CLU, MMP9
20	mortality/aging	MP:0010768	5.8	IL6, APCS, APOA4, APOB, APOE, APP
21	behavior/neurological phenotype	MP:0005386	5.8	HSPG2, EGR2, ACE, ACHE, AGER, AGT
22	growth/size phenotype	MP:0005378	5.5	LIF, AKR1B1, GJB1, AIRE, TP53, PYY
23	homeostasis/metabolism phenotype	MP:0005376	4.6	SLC25A19, PEX7, AAAS, EPO, GAS6, CNTF
24	cardiovascular system phenotype	MP:0005385	4.5	B2M, CD1D, ITGB8, MMP9, FKBP1A, INS
25	cellular phenotype	MP:0005384	INF	APOA4, PNPLA6, PLAT, NOS1, NOS2, NOS3
26	immune system phenotype	MP:0005387	INF	MBP, GPX1, HSPG2, AIRE, TP53, TNF

Articles related to polyneuropathy:

(show top 50)    (show all 376)

id	Title	Authors	Year	Affiliating Genes
1	Upper limb neuropathy such as carpal tunnel syndrome as an initial manifestation of ATTR Val30Met familial amyloid polyneuropathy. (20132088)	Tojo K.... Ikeda S.	2010	TTR
2	Quantitative sensation and autonomic test abnormaliti es in transthyretin amyloidosis polyneuropathy. (19618439)	Kim D.H.... Dyck P.J.	2009	TTR
3	Candidate biomarkers of chronic inflammatory demyelin ating polyneuropathy (CIDP): proteome analysis of cerebrospinal fluid. (19589605)	Tumani H.... Brettschneider J.	2009	TF, HP, APOA4
4	Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy. (19261857)	Tackenberg B.... LA1nemann J.D.	2009	FCGR2B
5	Activation of the heat shock response in familial amyloidotic polyneuropathy. (18431252)	Santos S.D.... Saraiva M.J.	2008	TTR
6	Acute inflammatory demyelinating polyneuropathy associated with pegylated interferon alpha 2a therapy for chronic hepatitis C virus infection. (18186575)	Khiani V.... Mohanty S.R.	2008	IFNA2
7	Transthyretin Ala97Ser in Chinese-Taiwanese patients with familial amyloid polyneuropathy: genetic studies and phenotype expression. (18022643)	Liu Y.T.... Lin K.P.	2008	TTR
8	Severe amyloid deposition in mammary glands of familial amyloid polyneuropathy patients. (17701472)	Tokuda T.... Ikeda S.	2007	APP, TTR
9	Diagnostic pitfalls in sporadic transthyretin familial amyloid polyneuropathy (TTR-FAP). (17698792)	Plante-Bordeneuve V.... Said G.	2007	TTR
10	Role of NF2 haploinsufficiency in NF2-associated polyneuropathy. (17655741)	Hanemann C.O.... Kaufmann D.	2007	NF2
11	Gene expression profiling in chronic inflammatory demyelinating polyneuropathy. (15652421)	Renaud S.... Latov N.	2005	AIF1
12	The AGE/RAGE/NF-(kappa)B pathway may contribute to the pathogenesis of polyneuropathy in impaired glucose tolerance (IGT). (15926115)	Haslbeck K.M.... Heuss D.	2005	AGER
13	Changes in renal function in patients with familial amyloid polyneuropathy treated with orthotopic liver transplantation. (15150345)	Snanoudj R.... Charpentier B.	2004	TTR
14	Early detection of sympathetic myocardial denervation in patients with familial amyloid polyneuropathy type I. (15116456)	Coutinho C.A.... Vagueiro M.C.	2004	TTR
15	Outcome of exercise electrocardiography in familial amyloidotic polyneuropathy patients, Portuguese type, under evaluation for liver transplantation. (15523924)	Juneblad K.... Suhr O.B.	2004	TTR
16	Biophysical analyses of the transthyretin variants, Tyr114His and Tyr116Ser, associated with familial amyloidotic polyneuropathy. (14690414)	Shinohara Y.... Kawano K.	2003	TTR
17	Parallel expression of neurotrophic factors and their receptors in chronic inflammatory demyelinating polyneuropathy. (11932979)	Yamamoto M.... Sobue G.	2002	NGF, GDNF, CNTF
18	Can electrophysiology differentiate polyneuropathy with anti-MAG/SGPG antibodies from chronic inflammatory demyelinating polyneuropathy? (11897535)	Capasso M.... Uncini A.	2002	MAG
19	Expression of chemokines in cerebrospinal fluid and serum of patients with chronic inflammatory demyelinating polyneuropathy. (12185171)	Mahad D.J.... Woodroofe M.N.	2002	CXCL9
20	A case of familial amyloid polyneuropathy homozygous for the transthyretin Val30Met gene with motor-dominant sensorimotor polyneuropathy and unusual sural nerve pathological findings. (11709003)	Yoshioka A.... Ando Y.	2001	TTR
21	Familial amyloid polyneuropathy: receptor for advanced glycation end products-dependent triggering of neuronal inflammatory and apoptotic pathways. (11567048)	Sousa M.M.... Saraiva M.J.	2001	TTR
22	Vitreous amyloidosis after liver transplantation in patients with familial amyloid polyneuropathy: ocular synthesis of mutant transthyretin. (11132095)	Munar-Ques M.... Saraiva M.J.	2000	TTR
23	The importance of TTR met 30 in the diagnosis of familial amyloidotic polyneuropathy in the absence of a positive family history (10919188)	Santos M.... EsperanAsa P.	2000	TTR
24	Steroid responsive polyneuropathy in a family with a novel myelin protein zero mutation. (11080236)	Donaghy M.... Bell C.	2000	MPZ
25	A novel variant of transthyretin (Glu89Lys) associated with familial amyloidotic polyneuropathy. (10842705)	Nakamura M.... Benson M.D.	2000	TTR
26	Effect of sildenafil citrate (Viagra) on erectile dysfunction in a patient with familial amyloidotic polyneuropathy ATTR Val30Met. (10742545)	Obayashi K.... Ando M.	2000	TTR
27	Late-onset familial amyloid polyneuropathy type I (transthyretin Met30-associated familial amyloid polyneuropathy) unrelated to endemic focus in Japan. Clinicopathological and genetic features. (10506096)	Misu K.... Sobue G.	1999	TTR
28	Familial amyloidotic polyneuropathy type 1 in Brazil is associated with the transthyretin Val30Met variant. (10611951)	Palacios S.A.... Goldberg A.C.	1999	TTR
29	Risk factors for progression of distal symmetric polyneuropathy in type 1 diabetes mellitus. Sorbinil Retinopathy Trial Research Group. (10588075)	Christen W.G.... Glynn R.J.	1999	AKR1B1
30	A case of hereditary amyloidosis transthyretin varian t Met 30 with amyloid cardiomyopathy, less polyneuropathy, and the presence of giant cells. (10571824)	Nakamura Y.... Goto Y.	1999	TTR
31	New transthyretin variants Ser 91 and Ser 116 associated with familial amyloidotic polyneuropathy. (10627135)	Misrahi A.M.... Said G.	1998	TTR
32	Treatment of chronic inflammatory demyelinating polyneuropathy with interferon-alpha 2a. (9443462)	Gorson K.C.... Allam G.	1998	IFNA2
33	Domino liver transplantation for familial amyloid polyneuropathy. (9563964)	Hemming A.W.... Levy G.A.	1998	TTR
34	Effects of the aldose reductase inhibitor on diabetic polyneuropathy--the efficacy of F wave measurement (9789304)	Shimada H.... Morii H.	1998	AKR1B1
35	A randomised clinical trial comparing interferon-alpha and intravenous immunoglobulin in polyneuropathy associated with monoclonal IgM. The IgM-associated Polyneuropathy Study Group. (9221964)	Mariette X.... Brouet J.C.	1997	MAG
36	Familial amyloidotic polyneuropathy with a transthyretin variant (Val30-->Leu) (8865698)	Shimizu H.... Atsumi T.	1996	TTR
37	Chronic idiopathic axonal polyneuropathy. Comparison of patients with and without monoclonal gammopathy. (8800937)	Notermans N.C.... Lokhorst H.M.	1996	MAG
38	Familial amyloidotic polyneuropathy (FAP) type I and the therapies (8752420)	Ando Y.... Ando M.	1995	EPO
39	Acute axonal polyneuropathy during interferon alpha-2A therapy for chronic hepatitis type C. (7935561)	Negoro K.... Liao C.M.	1994	IFNA2
40	Familial amyloid polyneuropathy in Taiwan: identification of transthyretin variant (Leu55-->Pro). (7910950)	Yamamoto K.... Yanagisawa N.	1994	TTR
41	Genetic analysis and a new therapy for a hereditary disease: familial amyloid polyneuropathy (7844885)	Furihata K.	1994	TTR
42	Interactions between neuropathy target esterase and its inhibitors and the development of polyneuropathy. (8211998)	Lotti M.... Scapellato M.L.	1993	PNPLA6
43	Effect of serum amyloid P component level on transthyretin-derived amyloid deposition in a transgenic mouse model of familial amyloidotic polyneuropathy. (1497094)	Murakami T.... Araki S.	1992	TTR
44	Asymptomatic homozygous gene carrier in a family with type I familial amyloid polyneuropathy. (1490495)	Ikeda S.... Tsukagoshi H.	1992	TTR
45	A novel transthyretin mutation associated with familial amyloidotic polyneuropathy. (1734866)	Murakami T.... Araki S.	1992	TTR
46	Amyloid polyneuropathy with transthyretin Arg50 in a Japanese case from Osaka. (1335038)	Takahashi N.... Tarui S.	1992	TTR
47	A new transthyretin variant from a patient with familial amyloidotic polyneuropathy has asparagine substituted for histidine at position 90. (1997217)	Skare J.C.... Skinner M.	1991	TTR
48	Polyneuropathy syndromes associated with serum antibodies to sulfatide and myelin-associated glycoprotein. (1706491)	Pestronk A.... Peeples D.M.	1991	CD40LG, MAG
49	Peripheral polyneuropathy during treatment with alpha -2 interferon. (1965833)	Cudillo L.... Papa G.	1990	IFNA2
50	Presence of an abnormal transthyretin (prealbumin) in Portuguese patients with familial amyloidotic polyneuropathy. (6208668)	Saraiva M.J.... Goodman D.S.	1983	TTR

Genes related to polyneuropathy according to GeneCards:

(show top 50)    (show all 148)

id	Symbol	Description	Score	GeneCards Section Context
1	TTR	transthyretin	11.1	Summaries, Publications
2	MPZ	myelin protein zero	11.1	Summaries, Publications
3	ABHD12	abhydrolase domain containing 12	11.1	Summaries
4	MAG	myelin associated glycoprotein	11.0	Publications
5	CNTF	ciliary neurotrophic factor	11.0	Publications
6	AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)	11.0	Publications
7	NGF	nerve growth factor (beta polypeptide)	11.0	Publications
8	DHH	desert hedgehog	11.0	Summaries
9	AIF1	allograft inflammatory factor 1	11.0	Publications
10	PMP22	peripheral myelin protein 22	11.0	Publications
11	FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	11.0	Publications
12	FYB	FYN binding protein	11.0	Publications
13	GSN	gelsolin	11.0	Publications
14	TUBB	tubulin, beta class I	11.0	Publications
15	GDNF	glial cell derived neurotrophic factor	11.0	Publications
16	CD28	CD28 molecule	11.0	Publications
17	IFNA2	interferon, alpha 2	11.0	Publications
18	TNF	tumor necrosis factor	11.0	Publications
19	CLDN5	claudin 5	11.0	Publications
20	AIRE	autoimmune regulator	11.0	Publications
21	CD1D	CD1d molecule	11.0	Publications
22	GAS6	growth arrest-specific 6	11.0	Publications
23	CXCL9	chemokine (C-X-C motif) ligand 9	11.0	Publications
24	POLG	polymerase (DNA directed), gamma	11.0	Publications
25	NTF3	neurotrophin 3	11.0	Publications
26	CD40LG	CD40 ligand	11.0	Publications
27	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
28	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
29	IFNA1	interferon, alpha 1	11.0	Publications
30	SLC25A5P3	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 pseudogene 3	11.0	Publications
31	IGLJ3	immunoglobulin lambda joining 3	11.0
32	PNPLA6	patatin-like phospholipase domain containing 6	11.0	Publications
33	CD52	CD52 molecule	11.0	Publications
34	PRX	periaxin	11.0	Publications
35	SOD3	superoxide dismutase 3, extracellular	11.0	Publications
36	PRPS1	phosphoribosyl pyrophosphate synthetase 1	11.0
37	PTGDS	prostaglandin D2 synthase 21kDa (brain)	11.0	Publications
38	C10orf2	chromosome 10 open reading frame 2	11.0	Publications
39	SLC25A4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	11.0	Publications
40	ARSA	arylsulfatase A	11.0	Publications
41	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	11.0	Publications
42	EGR2	early growth response 2	11.0
43	CS	citrate synthase	11.0	Publications
44	GPX1	glutathione peroxidase 1	11.0	Publications
45	BLVRB	biliverdin reductase B (flavin reductase (NADPH))	11.0	Publications
46	CNTN2	contactin 2 (axonal)	11.0	Publications
47	APOA2	apolipoprotein A-II	11.0	Publications
48	GJB1	gap junction protein, beta 1, 32kDa	11.0
49	LIF	leukemia inhibitory factor	11.0	Publications
50	RBP4	retinol binding protein 4, plasma	11.0	Publications

Pathways related to polyneuropathy according to GeneDecks:

(show top 50)    (show all 89)

id	Pathway	Score	Top Affiliating Genes
1	Doxorubicin Pathway, Pharmacokinetics34	10.8	GPX1, SOD1, NOS3, NOS2, NOS1, CAT
2	Cell adhesion molecules (CAMs)20	10.7	MAG, CNTN2, CTLA4, CLDN5, MPZ, CD28
3	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	10.6	TP53, NOS3, GPX1, CAT, NFKB1, SOD1
4	Autoimmune thyroid disease20	10.6	CTLA4, HLA-DRB1, IFNA2, IFNA1, IL10, CD28
5	ACE Inhibitor Pathway, Pharmacodynamics34	10.5	MAPK3
6	Systemic lupus erythematosus20	10.3	C1QA, TNF, CD28, HLA-DRB1, IL10, FCGR2B
7	Staphylococcus aureus infection20	10.3	CFB, FCGR2B, IL10, HLA-DRB1, C1QA, C1QB
8	Neuroscience3	10.2	NOS1, NF2, NGF, PARK7, TUBB3, APP
9	Glioma Invasiveness36	10.1	BMP6, ITGB8, NTF3, TIMP1, GAS6
10	IL-6 Pathway36	10.1	CSF1, TIMP1, BMP6, IL10, MAPK3, MAPK1
11	Akt Signaling36	10.0	GAS6, CXCL9, TNF, IL6, ITGB8, CD4
12	Cytokine Network36	9.9	IL6, IL1B, IL10, IFNA2, IFNA1, TNF
13	Cytokine-cytokine receptor interaction20	9.9	IL10, CD40LG, LIF, VEGFA, CNTF, IL1B
14	Rheumatoid arthritis20	9.6	CSF1, CTLA4, TNF, IL6, IL1B, CD28
15	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	9.6	AGT, MAPK3, MAPK1, NOS3, ACE
16	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	9.5	NOS1, SOD2, NFKB1, MAPK3, MAPK1
17	Regulation of eIF4 and p70S6K36	9.5	NTF3, MAPK3, IL6, ITGB8, CD4
18	Immune response_MIF in innate immunity response41	9.5	NFKB1, IL1B, IL6, TP53, NOS2, TNF
19	Immune response MIF in innate immunity response10	9.5	NFKB1, NOS2, TNF, TP53, IL6, IL1B
20	Selected targets of HNF110	9.5	GJB1, APOA2, APOA1, INS, CRP, APOB
21	Cellular Apoptosis Pathway36	9.5	NFKB1, PRPS1, TIMP1, SLC25A4, NTF3, TP53
22	Rho Family GTPases36	9.3	IL1B, MAPK3, MAPK1, HSPG2, NTF3, NFKB1
23	Immune response MIF-mediated glucocorticoid regulation10	9.3	NOS2, IL6, MAPK3, MAPK1, TNF, NFKB1
24	Immune response_MIF-mediated glucocorticoid regulation41	9.3	NFKB1, NOS2, MAPK3, TNF, MAPK1, IL6
25	Leishmaniasis20	9.3	NOS2, IL10, IL1B, NFKB1, TNF, HLA-DRB1
26	p38 Signaling36	9.3	CSF1, BMP6, CD28, CD4, IL10, IL1B
27	Hematopoietic cell lineage20	9.3	CSF1, HLA-DRB1, IL1B, TNF, CD1E, CD4
28	Endothelin-1 Signaling Pathway36	9.3	MAPK1, MAPK3, CXCL9, IL1B, IL10, BMP6
29	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	9.3	MAPK3, NFKB1, SOD2, MAPK1, NOS1
30	PEDF Induced Signaling36	9.1	MAPK1, BMP6, LIF, IL10, IL1B, IL6
31	MIF Mediated Glucocorticoid Regulation36	9.1	IL10, BMP6, MAPK3, MAPK1, TNF, NFKB1
32	STAT3 Pathway36	9.1	MAPK3, MAPK1, TNF, CSF1, BMP6, CXCL9
33	Prion diseases20	9.1	SOD1, IL1B, IL6, MAPK3, MAPK1, HSPA1A
34	MIF Regulation of Innate Immune Cells36	9.1	CXCL9, CSF1, IL6, NFKB1, TNF, BMP6
35	Molecular Mechanisms of Cancer36	9.1	TIMP1, LIF, CD4, ITGB8, IL6, MAPK1
36	NFAT in Immune Response36	9.0	MAPK1, CD28, HLA-DRB1, BMP6, CD4, CD79A
37	Pertussis20	9.0	TNF, C1QC, C1QA, NFKB1, IL10, IL1B
38	Tuberculosis20	8.8	HLA-DRB1, TNF, NOS2, MAPK1, MAPK3, IFNA2
39	Antioxidant Action of Vitamin-C36	8.7	BMP6, IL1B, GAS6, CSF1, CXCL9, TNF
40	ERK Signaling36	8.7	CXCL9, TIMP1, NFKB1, ITGB8, BMP6, GAS6
41	JAK-STAT Pathway36	8.4	BMP6, CD4, IL10, IL1B, IL6, MAPK3
42	Glucocorticoid Receptor Signaling36	8.1	BMP6, MAPK3, HDAC9, NFKB1, HSPA1A, MAPK1
43	Chagas disease (American trypanosomiasis)20	INF	IL1B, ACE, , IL10, IL6, MAPK3
44	Hepatitis C20	INF	IFNA2, IFNA1, NFKB1, TNF, MAPK1, MAPK3
45	Amoebiasis20	INF	IL6, NOS2, IL1B, CD1D,
46	Toll-like receptor signaling pathway20	INF	, NFKB1, TNF, IFNA2, IFNA1, MAPK1
47	Toxoplasmosis20	INF	MAPK3, TNF, NFKB1, NOS2, HLA-DRB1, HSPA1A
48	Measles20	INF	NFKB1, MSN, CD28, FCGR2B, IL1B, IL6
49	T cell receptor signaling pathway20	INF	MAPK3, CTLA4, TNF, MAPK1, IL10, CD40LG
50	Influenza A20	INF	IFNA2, MAPK1, MAPK3, IL6, IL1B, HSPA1A

Compounds related to polyneuropathy according to GeneDecks:

(show top 50)    (show all 486)

id	Compound	Score	Top Affiliating Genes
1	nadph32 18	11.7	LPO, BLVRB, GLRX, AHSP, DBH
2	glucose32	10.6	CNTF, LPO, BLVRB, SCT, CFB, GSN
3	nitroglycerin32 9 9	12.4	BLVRB, B2M, ALDH2, SST
4	ivig32	10.3	FCGR2B, MBP, MAG, CRP, CSF1
5	methionine32	10.1	CNTF, LPO, LIF, PARK7, S100A9, MPZ
6	vitamin-e32	10.1	CNTF, RBP4, LPO, B2M, GSTT1, GPT
7	rituximab32 34 9 9	12.8	CD79A, CD40LG, CD52, FCGR2B, IL10, MAG
8	hyaluronic acid32 18	10.8	BMP6, B2M, MSN, MFAP2, GPT, TTR
9	superoxide32 18	10.7	CNTF, LPO, LIF, BLVRB, CLU, PARK7
10	aminoguanidine32 9 9	11.7	CLU, IL1B, APOB, ALB, HSPA1A, AKR1B1
11	h2o232	9.7	CNTF, CNTN2, LPO, LIF, CLU, PARK7
12	gaba32 42	10.6	CNTF, BLVRB, SCT, APP, MBP, HSPG2
13	choline32 9 18 9	12.5	CNTF, CNTN2, LIF, BLVRB, APOA1, APOB
14	aspartate32	9.4	RBP4, SERPINA7, BMP6, SCT, B2M, MPZ
15	valine32	9.3	RBP4, B2M, ARSA, GSTM1, GSTT1, APOE
16	oxygen32 18	10.2	CNTN2, RBP4, LPO, LIF, BLVRB, CLU
17	homocysteine32 18	10.2	APOA1, APOB, APOE, GPX1, ALB, HP
18	prednisolone32 9 9	11.2	BMP6, CD79A, GSTM1, IL10, IL6, APOB
19	4-hydroxynonenal32 18	10.1	PARP1, GSTM1, IL10, APOB, APOE, APP
20	heparin32 9 18 9	12.0	LIF, CD79A, CD4, GSN, APOA2, APOA4
21	n acetylcysteine32	9.0	CLU, CD79A, MMP9, APOE, MBP, GPT
22	acetylcholine32 9 18 9	12.0	CNTF, BMP6, LIF, BLVRB, SCT, CD79A
23	vitamin a32 9 18 9	12.0	RBP4, SERPINA7, B2M, CD1D, GSTM1, APOA4
24	thalidomide32 42 9 9	11.9	VEGFA, B2M, CD40LG, IL10, IL1B, IL6
25	calcium32 9 18 9	11.7	CNTF, CNTN2, RBP4, LPO, LIF, BLVRB
26	thymidine32 18	9.7	CNTF, CNTN2, BMP6, LIF, CLU, SCT
27	aspirin32 34 18	10.5	SERPINA7, BMP6, CD79A, CD40LG, APOA1, APOB
28	thyroxine32 18	9.5	RBP4, SERPINA7, LPO, SCT, B2M, CD79A
29	cysteine32	8.4	CNTN2, RBP4, LPO, LIF, CLU, PARP1
30	glutamine32	8.3	BMP6, SCT, B2M, ARSA, APOA2, APOA4
31	estrogen32	8.3	RBP4, SERPINA7, CLU, MSN, INS, FCGR2B
32	prostacyclin32	8.3	VEGFA, BMP6, IL10, IL1B, APOA1, APOE
33	indomethacin32 9 9	10.3	BMP6, BLVRB, SCT, B2M, CD79A, CD40LG
34	nitric oxide32 9 18 9	11.2	CNTF, LPO, BMP6, LIF, BLVRB, S100A8
35	neopterin32	8.1	B2M, CD79A, CD4, CD40LG, IL10, IL1B
36	genistein32 9 18 9	11.0	CNTF, VEGFA, LIF, PARP1, B2M, CD28
37	creatinine32	7.9	RBP4, SERPINA7, BMP6, S100A8, B2M, MPZ
38	epinephrine32 9 18 9	10.9	LPO, BMP6, SCT, CD79A, MMP9, INS
39	curcumin32	7.9	VEGFA, PARP1, MPZ, MMP9, IL1B, IL6
40	ly29400232	7.9	VEGFA, MMP9, FKBP1A, IL10, IL1B, IL6
41	8-isoprostane32	7.8	MMP9, INS, IL10, IL6, HSPA1A, CAT
42	fibrinogen32	7.6	LIF, CLU, S100A9, CD79A, CD40LG, INS
43	arginine32	7.3	CNTF, CNTN2, SERPINA7, LPO, LIF, BLVRB
44	methotrexate32 34 42 9 9	11.1	BMP6, S100A8, S100A9, CD79A, MMP9, GSTM1
45	retinoic acid32 42 18	8.7	CNTF, CNTN2, RBP4, BMP6, LIF, CLU
46	alanine32	6.6	CNTF, CNTN2, RBP4, SERPINA7, BMP6, S100A8
47	glutamate32	6.4	CNTN2, BMP6, BLVRB, CLU, S100A8, MPZ
48	dexamethasone32 42 34 9 9	10.2	RBP4, VEGFA, BMP6, LIF, CLU, PARP1
49	lipid32	5.8	CNTF, RBP4, SERPINA7, LPO, LIF, CLU
50	cholesterol32 9 18 9	8.6	RBP4, SERPINA7, LIF, CLU, S100A8, S100A9

Cellular components related to polyneuropathy according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	very-low-density lipoprotein particle	GO:034361	10.3	APOE, APOB, APOA4, APOA2, APOA1
2	high-density lipoprotein particle	GO:034364	10.2	APOA1, APOA2, APOA4, APOE
3	chylomicron	GO:042627	10.1	APOE, APOB, APOA4, APOA2
4	perinuclear region of cytoplasm	GO:048471	9.8	CSF1, TF, ACHE, NDRG1, NF2, NOS2
5	platelet alpha granule lumen	GO:031093	9.8	GAS6, TIMP1, ALB, APP, CLU, VEGFA
6	external side of plasma membrane	GO:009897	9.6	TNF, CTLA4, ACE, CXCL9, HLA-DRB1, CD40LG
7	endoplasmic reticulum lumen	GO:005788	9.4	GAS6, NGF, APOB, APOA4, APOA2, APOA1
8	secretory granule	GO:030141	9.0	DBH, TF, PLAT, APOA1, IL1B, INS
9	plasma membrane	GO:005886	7.3	NDRG1, SH3TC2, NF2, COMT, NOS3, NTF3
10	extracellular space	GO:005615	6.0	GAS6, CNTF, INS, GSN, IL10, IL1B
11	extracellular region	GO:005576	4.9	SERPINA7, APOA2, APOA4, APOB, APOE, APP
12	cytosol	GO:005829	INF	NOS1, TP53, TUBB, AIF1, AKR1B1, GLRX

Biological processes related to polyneuropathy according to GeneDecks:

(show top 50)    (show all 55)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cytokine secretion involved in immune response	GO:002740	10.9	TNF, APOA2, APOA1, IL10
2	negative regulation of neuron apoptotic process	GO:043524	10.7	GDNF, SOD2, SOD1, AGT, NGF, NTF3
3	regulation of intestinal cholesterol absorption	GO:030300	10.7	APOA1, APOA2, APOA4
4	negative regulation of hydrolase activity	GO:051346	10.6	NOS3, NOS1, APOA1
5	protein oxidation	GO:018158	10.6	GPX1, APOA2, APOA1
6	phospholipid efflux	GO:033700	10.5	APOE, APOA4, APOA2, APOA1
7	lipoprotein metabolic process	GO:042157	10.5	HSPG2, ALB, APOE, APOB, APOA4, APOA2
8	response to salt stress	GO:009651	10.5	EPO, AGT, TNF, TP53
9	high-density lipoprotein particle remodeling	GO:034375	10.5	APOE, APOA1, APOA2, APOA4
10	reverse cholesterol transport	GO:043691	10.5	APOE, APOA4, APOA2, APOA1, CLU
11	cholesterol metabolic process	GO:008203	10.5	CAT, MBTPS2, APOE, APOB, APOA4, APOA2
12	response to copper ion	GO:046688	10.5	SOD3, SOD1, DBH, NFKB1
13	positive regulation of cholesterol esterification	GO:010873	10.5	AGT, APOE, APOA4, APOA2, APOA1
14	neurotransmitter biosynthetic process	GO:042136	10.4	ACHE, COMT, NOS1, ALDH2
15	high-density lipoprotein particle assembly	GO:034380	10.4	APOE, APOA2, APOA1
16	response to peptide hormone stimulus	GO:043434	10.4	DBH, TIMP1, NGF, NOS3, PLAT, SERPINA7
17	positive regulation of macrophage derived foam cell differentiation	GO:010744	10.4	APOB, NFKB1, AGT, CSF1
18	blood vessel remodeling	GO:001974	10.3	DBH, AGT, ACE, NOS3, LIF
19	regulation of ARF protein signal transduction	GO:032012	10.3	PSD4, PSD3, PSD, PSD2
20	response to ethanol	GO:045471	10.3	SOD1, NOS3, GSN, MMP9, S100A9, S100A8
21	lipid metabolic process	GO:006629	10.2	HSPG2, ALB, APOE, APOB, APOA4, APOA2
22	immune response	GO:006955	10.2	AIRE, HLA-DRB1, CTLA4, C1QC, CXCL9, CST7
23	response to hyperoxia	GO:055093	10.2	MMP9, CAT, NOS3, EPO
24	aging	GO:007568	10.1	EPO, TIMP1, AGT, C1QB, NOS3, IL1B
25	platelet degranulation	GO:002576	10.0	GAS6, SOD1, TF, TIMP1, ALB, APP
26	anti-apoptosis	GO:006916	10.0	NGF, NFKB1, SOD1, EPO, GDNF, NOS3
27	hydrogen peroxide catabolic process	GO:042744	10.0	CAT, GPX1, APOA4, LPO
28	embryo implantation	GO:007566	10.0	EPO, SOD1, IL1B, MMP9, LIF
29	positive regulation of protein phosphorylation	GO:001934	10.0	GAS6, TNF, AIF1, MAPK3, IL1B, VEGFA
30	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.9	GAS6, TNF, IL6, LIF, VEGFA
31	response to heat	GO:009408	9.9	SOD1, NOS3, NOS1, SST, IL1B, MMP9
32	positive regulation of apoptotic process	GO:043065	9.9	SOD1, AGT, NOS3, CTLA4, TNF, TP53
33	response to lipopolysaccharide	GO:032496	9.9	EPO, THBD, NGF, COMT, APOB, MMP9
34	positive regulation of T cell proliferation	GO:042102	9.8	AIF1, IL6, IL1B, CD1D, CD28
35	response to glucocorticoid stimulus	GO:051384	9.8	C1QB, NGF, PLAT, PTGDS, TNF, APOA2
36	negative regulation of lipid catabolic process	GO:050995	9.7	IL1B, APOA2, TNF, INS
37	response to drug	GO:042493	9.7	NOS3, COMT, NGF, SOD1, SLC6A4, SST
38	negative regulation of lipid storage	GO:010888	9.4	IL6, TNF, CRP
39	cell-cell signaling	GO:007267	9.3	NTF3, C1QA, AGT, DHH, CXCL9, SST
40	response to hypoxia	GO:001666	9.2	SLC6A4, SOD3, NOS3, NOS2, NOS1, PLAT
41	negative regulation of cell proliferation	GO:008285	9.1	PMP22, SOD2, AGT, NF2, NOS3, SST
42	innate immune response	GO:045087	9.0	NFKB1, C1QA, C1QC, C1QB, AGER, CSF1
43	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.0	AGT, TP53, IL6, INS, CD4, LIF
44	negative regulation of apoptotic process	GO:043066	9.0	GAS6, EPO, SOD2, TIMP1, TNF, TP53
45	acute-phase response	GO:006953	8.7	ORM1, CRP, APCS, IL6, INS
46	inflammatory response	GO:006954	8.6	BMP6, CRP, NGF, NFKB1, AGER, ORM1
47	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.6	AGT, AGER, NFKB1, TNF, CAT, IL6
48	small molecule metabolic process	GO:044281	INF	HSPG2, CAT, GLRX, AKR1B1, NOS3, COMT
49	blood coagulation	GO:007596	INF	TP53, PLAT, NOS1, NOS2, NOS3, TIMP1
50	platelet activation	GO:030168	INF	MAPK1, ALB, TIMP1, TF, SOD1, GAS6

Molecular functions related to polyneuropathy according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	tetrahydrobiopterin binding	GO:034617	10.5	NOS3, NOS2, NOS1
2	nitric-oxide synthase activity	GO:004517	10.5	NOS3, NOS2, NOS1
3	arginine binding	GO:034618	10.4	NOS1, NOS2, NOS3
4	cholesterol transporter activity	GO:017127	10.4	APOB, APOA4, APOA2, APOA1
5	phosphatidylcholine-sterol O-acyltransferase activator activity	GO:060228	10.3	APOE, APOA4, APOA2, APOA1
6	cytokine activity	GO:005125	9.9	CSF1, CXCL9, TNF, IFNA2, IL6, IL1B
7	protease binding	GO:002020	9.9	POLG, C10orf2, TNF, TP53, MBP, INS
8	antioxidant activity	GO:016209	9.8	CAT, ALB, APOE, APOA4
9	receptor binding	GO:005102	9.8	GDNF, GAS6, NOS2, NTF3, CAT, AMACR
10	growth factor activity	GO:008083	9.7	NTF3, NGF, AGT, CSF1, GDNF, IL6
11	protein homodimerization activity	GO:042803	9.1	C1QB, ACHE, PRPS1, SOD1, CSF1, SLC6A4
12	hormone activity	GO:005179	8.6	EPO, TTR, AGT, LRSAM1, SST, PYY
13	protein binding	GO:005515	3.7	GAN, ACHE, ACE, EGR2, C1QB, C1QA