MCID: PLY019
MIFTS: 60

Polyneuropathy malady

Neuronal diseases category

Summaries for Polyneuropathy

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Polyneuropathy or symmetrical polyneuropathy (poly- + neuro- + -pathy) is damage or disease affecting... more...

MalaCards: Polyneuropathy, also known as polyneuropathy, unspecified, is related to diabetic polyneuropathy and neuropathy. An important gene associated with Polyneuropathy is TTR (transthyretin). The compounds deae and megestrol acetate have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and testes, and related mouse phenotypes are vision/eye and muscle.

Aliases & Classifications for Polyneuropathy

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Related Diseases for Polyneuropathy

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 494)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic polyneuropathy31.6NGF, AKR1B1
2neuropathy31.0AKR1B1, TTR, NGF, PMP22
3myopathy30.7CD59, NGF, PMP22
4carpal tunnel syndrome30.6TTR, PMP22
5guillain-barre syndrome30.4PMP22, TUBB
6diabetic neuropathy30.2GDNF, PMP22, NGF, AKR1B1, CNTF
7autonomic neuropathy30.2AKR1B1, TTR, NGF
8leukemia30.1GDNF, NGF, TTR, AKR1B1, IFNA2, CNTF
9malaria30.1CNTF
10multiple sclerosis30.1TUBB, NGF, CNTF, CD59
11amyotrophic lateral sclerosis30.1CNTF, NGF, GDNF
12melanoma30.0GDNF, TUBB, AKR1B1, IFNA2, CD59
13parkinson's disease30.0CNTF, TTR, NGF, GDNF
14motor neuron disease29.9CNTF, GDNF
15ischemia29.8GDNF, AKR1B1, CNTF, CD59
16demyelinating polyneuropathy11.1
17chronic inflammatory demyelinating polyneuropathy11.1
18critical illness polyneuropathy10.8
19poems syndrome10.6
20chronic polyneuropathy10.5
21amyloidosis10.4
22diabetes mellitus10.4
23myeloma10.4
24transthyretin amyloidosis10.3
25hepatitis10.3
26sepsis10.3
27blindness10.3
28osteosclerotic myeloma10.3
29paraneoplastic polyneuropathy10.3
30subacute inflammatory demyelinating polyneuropathy10.3
31hepatitis c10.2
32myasthenia gravis10.2
33type 1 diabetes mellitus10.2
34beriberi10.2
35cerebritis10.2
36alcoholic neuropathy10.2
37polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract10.2
38ataxia10.2
39endotheliitis10.2
40charcot-marie-tooth disease10.1
41respiratory failure10.1
42optic atrophy polyneuropathy deafness10.1
43hepatitis c virus10.1
44neuronitis10.1
45churg-strauss syndrome10.1
46systemic lupus erythematosus10.1
47eosinophilia10.1
48lupus erythematosus10.1
49peritonitis10.1
50tooth disease10.1

Graphical network of the top 20 diseases related to Polyneuropathy:



Diseases related to polyneuropathy

Symptoms for Polyneuropathy

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Drugs & Therapeutics for Polyneuropathy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Polyneuropathy

Drug clinical trials:

Search ClinicalTrials for Polyneuropathy

Search NIH Clinical Center for Polyneuropathy

Search CenterWatch for Polyneuropathy

Genetic Tests for Polyneuropathy

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Anatomical Context for Polyneuropathy

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34MalaCards
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MalaCards organs/tissues related to Polyneuropathy:

34
Liver, Skin, Testes, Bone, T cells, Heart, Endothelial, Spinal cord, Kidney, B cells, Bone marrow, Brain, Pancreas, Myeloid, Breast, Nk cells, Thalamus, Prostate, Thyroid, Lung, Colon, Lymph node, Eye, Dorsal root ganglion

Animal Models for Polyneuropathy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Polyneuropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.4ABHD12, AKR1B1, TTR, NGF, PMP22
2MP:00053698.4GDNF, CNTF, NGF, PMP22, ABHD12
3MP:00053867.6PMP22, CNTF, AKR1B1, ABHD12, FCGR2B, GDNF
4MP:00036317.5CNTF, DHH, FCGR2B, NGF, PMP22, ABHD12
5MP:00053767.4NGF, ABHD12, TTR, FCGR2B, AKR1B1, DHH

Publications for Polyneuropathy

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Sources:
53PubMed
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Articles related to Polyneuropathy:

(show top 50)    (show all 1719)
idTitleAuthorsYear
1
Exercise interventions, gait, and balance in older subjects with distal symmetric polyneuropathy: a three-group randomized clinical trial. (24355993)
2014
2
Assessment of paclitaxel induced sensory polyneuropathy with "Catwalk" automated gait analysis in mice. (24143194)
2013
3
Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice. (24319678)
2013
4
CD19 as a Therapeutic Target in a Spontaneous Autoimmune Polyneuropathy. (24116957)
2013
5
Peripheral nociceptor sensitization mediates allodynia in patients with distal symmetric polyneuropathy. (23052607)
2013
6
A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy. (23393557)
2013
7
A case of paraneoplastic demyelinating motor polyneuropathy. (22649345)
2012
8
Neuromuscular ultrasound in the diagnosis of focal neuropathies superimposed on polyneuropathy: a case report. (21835689)
2012
9
Bortezomib and dexamethasone as first-line therapy for a patient with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes syndrome complicated by renal failure. (22553961)
2012
10
Relationship between amyloid deposition and intracellular structural changes in familial amyloidotic polyneuropathy. (21777941)
2012
11
Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects. (22734904)
2012
12
Multiple endocrine neoplasia type 1 presenting as refractory epilepsy and polyneuropathy--a case report. (22138026)
2012
13
Subacute inflammatory demyelinating polyneuropathy disclosed by massive nerve root enhancement in CMT1A. (22173780)
2012
14
Painful polyneuropathy secondary to prolonged treatment with linezolid: presentation of a case. (22217521)
2012
15
Polyneuropathy due to cyclosporine A in patients with renal transplantation: a case report. (21545310)
2011
16
Polymorphisms of GSTT1, GSTM1, and EPHX genotypes in patients with cryptogenic polyneuropathy: a case-control study. (22399093)
2011
17
Differential gene expression in chronic inflammatory demyelinating polyneuropathy (CIDP) skin biopsies. (19922956)
2010
18
Atypical childhood chronic inflammatory demyelinating polyneuropathy. (20589891)
2010
19
Alemtuzumab in the treatment of IVIG-dependent chronic inflammatory demyelinating polyneuropathy. (20049473)
2010
20
Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. (19720975)
2009
21
Immunoglobulin M deposition in cutaneous nerves of anti-myelin-associated glycoprotein polyneuropathy patients correlates with axonal degeneration. (19151627)
2009
22
SELDI-TOF mass spectrometry evaluation of variant transthyretins for diagnosis and pathogenesis of familial amyloidotic polyneuropathy. (19372189)
2009
23
Electrophysiology in chronic inflammatory demyelinating polyneuropathy with IGIV. (19260050)
2009
24
Quantitative sensation and autonomic test abnormalities in transthyretin amyloidosis polyneuropathy. (19618439)
2009
25
Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy. (19915301)
2009
26
Fatigue in chronic inflammatory demyelinating polyneuropathy. (19347932)
2009
27
Motor variant of chronic inflammatory demyelinating polyneuropathy in a child. (18486826)
2008
28
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. (18473286)
2008
29
A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy. (17306302)
2007
30
Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis. (17712474)
2007
31
Severe amyloid deposition in mammary glands of familial amyloid polyneuropathy patients. (17701472)
2007
32
The diagnosis and management of familial amyloid polyneuropathy]. (17086153)
2006
33
Organophosphate-induced delayed polyneuropathy. (16042503)
2005
34
Acute inflammatory demyelinating polyneuropathy in patients with pregnancy. (15269509)
2004
35
Clinical and pathological studies of cardiac amyloidosis in transthyretin type familial amyloid polyneuropathy. (14986482)
2003
36
Subarachnoid block for a patient with progressive chronic inflammatory demyelinating polyneuropathy. (11682419)
2001
37
A case of familial amyloid polyneuropathy homozygous for the transthyretin Val30Met gene with motor-dominant sensorimotor polyneuropathy and unusual sural nerve pathological findings. (11709003)
2001
38
A comparison of diabetic polyneuropathy in type II diabetic BBZDR/Wor rats and in type I diabetic BB/Wor rats. (10907124)
2000
39
Optic atrophy and chronic acquired polyneuropathy. (10098553)
1999
40
Genotypic-phenotypic variations in a series of 65 patients with familial amyloid polyneuropathy. (9748014)
1998
41
Focal lesions area feature of chronic inflammatory demyelinating polyneuropathy (CIDP). (9845290)
1998
42
Idiopathic eosinophilic myositis associated with vasculitis and symmetrical polyneuropathy. (9133947)
1997
43
Chronic inflammatory demyelinating polyneuropathy (CIDP) in diabetics. (8902721)
1996
44
Chronic inflammatory demyelinating polyneuropathy. (8907837)
1994
45
A critical assessment of vascular factors in the causation of diabetic polyneuropathy. (8334845)
1993
46
Magnetic resonance imaging of the cauda equina in chronic inflammatory demyelinating polyneuropathy. (8388677)
1993
47
Myocardiopathy caused by Portuguese-type familial amyloidotic polyneuropathy. Sequential morphologic and functional study of 60 patients]. (1807296)
1991
48
A novel variant of transthyretin (Tyr114 to Cys) deduced from the nucleotide sequences of gene fragments from familial amyloidotic polyneuropathy in Japanese sibling cases. (2161654)
1990
49
Chronic inflammatory demyelinating polyneuropathy. Conduction failure before and during immunoglobulin or plasma therapy. (2597997)
1989
50
Chronic inflammatory demyelinating polyneuropathy of infancy: a corticosteroid-responsive disorder. (3017185)
1986

Variations for Polyneuropathy

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Expression for genes affiliated with Polyneuropathy

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyneuropathy

Search GEO for disease gene expression data for Polyneuropathy.

Pathways for genes affiliated with Polyneuropathy

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Compounds for genes affiliated with Polyneuropathy

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1deae469.9TUBB, TTR
2megestrol acetate469.8IFNA2, TTR
3vitamin-e469.7TTR, CNTF, IFNA2
43-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.5TUBB, NGF, IFNA2
5capsaicin46 3010.5AKR1B1, NGF, GDNF
6levodopa46 1210.4NGF, AKR1B1, GDNF
7epinephrine46 25 1211.4NGF, TTR, AKR1B1, IFNA2
8glycerol46 25 1211.4TUBB, NGF, AKR1B1, TTR
9cocaine46 1210.3GDNF, NGF, CNTF
10methionine469.3TUBB, TTR, IFNA2, CNTF
11valine469.3TUBB, NGF, TTR, IFNA2
12histamine46 30 2511.2NGF, FCGR2B, IFNA2, CNTF
13glutamine469.2AKR1B1, TTR, NGF, TUBB
14dihydrotestosterone46 30 25 1212.1PMP22, NGF, AKR1B1
15rituximab46 52 1211.1FCGR2B, CD59, IFNA2
16fitc469.1CD59, TUBB, FCGR2B
17actinomycin d469.1GDNF, NGF, AKR1B1, CNTF
18azathioprine46 3 52 1212.1NGF, IFNA2, CD59
19aspirin46 52 30 2512.0NGF, TTR, AKR1B1, CD59
20testosterone46 62 25 1212.0AKR1B1, CNTF, TTR, NGF, TUBB
21bromodeoxyuridine469.0CNTF, TUBB, GDNF
22ascorbic acid46 2510.0AKR1B1, IFNA2, PMP22, TTR, CNTF
23norepinephrine46 25 1211.0CNTF, AKR1B1, TTR, GDNF, NGF
24arginine469.0NGF, CNTF, AKR1B1, TTR, PMP22
25cyclosporin a46 30 6210.9AKR1B1, NGF, CD59, TTR
26gaba468.9CNTF, GDNF, PMP22, TUBB
27dopamine46 30 25 1211.9GDNF, NGF, TTR, IFNA2, CNTF
28thymidine46 259.8NGF, TUBB, CNTF, FCGR2B, IFNA2
29creatinine468.8TUBB, GDNF, NGF, TTR, AKR1B1
30vegf468.7NGF, IFNA2, CNTF, AKR1B1, GDNF
31glutamate468.7GDNF, TTR, CNTF, NGF, TUBB
32aspartate468.7PMP22, IFNA2, TTR, GDNF
33lactate468.7AKR1B1, CD59, TTR, TUBB
34inositol468.6FCGR2B, CD59, AKR1B1
35genistein46 30 62 3 25 1213.6CNTF, GDNF, NGF, FCGR2B, AKR1B1, TTR
36forskolin46 52 1210.5PMP22, NGF, TUBB, GDNF, CNTF
37iron46 259.5IFNA2, CD59, GDNF, TTR
38adenylate468.5GDNF, AKR1B1, TTR, NGF, TUBB, CNTF
39retinoic acid46 259.3GDNF, TTR, NGF, PMP22, IFNA2, CNTF
40estrogen468.3AKR1B1, TUBB, FCGR2B, GDNF, TTR, IFNA2
41superoxide46 259.3IFNA2, GDNF, FCGR2B, CNTF, CD59
42ganglioside468.3PMP22, NGF, CD59, CNTF, GDNF
43glucose468.0TTR, IFNA2, CNTF, CD59, GDNF, AKR1B1
44alanine468.0IFNA2, TTR, CNTF, TUBB, NGF, GDNF
45oxygen46 258.9AKR1B1, CD59, GDNF, IFNA2, TUBB
46phosphatidylinositol467.8CD59, GDNF, FCGR2B, CNTF, TUBB, NGF
47cysteine467.8AKR1B1, TTR, NGF, PMP22, TUBB, GDNF
48lipid467.7TUBB, FCGR2B, GDNF, CD59, CNTF, IFNA2
49serine467.5GDNF, TUBB, PMP22, NGF, TTR, FCGR2B
50tyrosine467.4GDNF, TUBB, NGF, IFNA2, CNTF, CD59

GO Terms for genes affiliated with Polyneuropathy

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17Gene Ontology
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Cellular components related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:0432188.8CD59, PMP22
2extracellular regionGO:0055767.9GDNF, NGF, TTR, IFNA2, CD59
3extracellular spaceGO:0056157.5IFNA2, NGF, TTR, AKR1B1, CD59, CNTF

Biological processes related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.6CNTF, IFNA2
2adult locomotory behaviorGO:0083449.5NGF, GDNF
3peripheral nervous system developmentGO:0074229.3NGF, PMP22
4negative regulation of neuron apoptotic processGO:0435249.2CNTF, NGF, GDNF

Molecular functions related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2CNTF, NGF, GDNF

Products for genes affiliated with Polyneuropathy

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Sources for Polyneuropathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet