MCID: PLY019
MIFTS: 54

Polyneuropathy malady

Neuronal category

Summaries for Polyneuropathy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Polyneuropathy or symmetrical polyneuropathy (poly- + neuro- + -pathy) is damage (peripheral neuropathy)... more...

MalaCards: Polyneuropathy, also known as polyneuropathy, unspecified, is related to diabetic polyneuropathy and amyloidosis. An important gene associated with Polyneuropathy is TTR (transthyretin), and among its related pathways are Influenza A and Cell adhesion molecules (CAMs). The compounds cysteine and lipid have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Polyneuropathy

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Related Diseases for Polyneuropathy

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Polyneuropathy family:

polyneuropathy due to drug chronic polyneuropathy

Diseases related to Polyneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 345)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic polyneuropathy31.5AKR1B1, NGF
2amyloidosis30.7TTR, GSN
3familial transthyretin amyloidosis30.5TTR, GSN
4hepatitis c30.4CD28, TNF, IFNA2
5amyloid neuropathy30.2TTR, GSN
6autonomic neuropathy30.2AKR1B1, NGF, TTR
7tooth disease30.2MPZ, PMP22
8amyotrophic lateral sclerosis30.1GDNF, NGF, CNTF, MAG
9hereditary amyloidosis30.0TTR, GSN
10cerebral amyloid angiopathy30.0TTR
11vasculitis30.0IFNA2, TNF
12diabetic autonomic neuropathy30.0NGF, AKR1B1
13hereditary neuropathies29.9PMP22, MPZ, MAG
14arthritis29.9TNF, FCGR2B
15finnish type amyloidosis29.9GSN, TTR
16chronic inflammatory demyelinating polyradiculoneuropathy29.9MPZ, PMP22
17parkinson's disease29.9GDNF, NGF
18asthma29.6GSN, CD28, NGF, TNF
19deficiency anemia29.6TTR, IFNA2
20brachial plexus neuropathy29.6MPZ, PMP22
21crohn's disease29.6TNF
22chronic inflammatory demyelinating polyneuropathy11.1
23critical illness polyneuropathy10.8
24poems syndrome10.6
25guillain-barr� syndrome10.5
26n syndrome10.5
27transthyretin amyloidosis10.5
28neuropathy, inflammatory demyelinating10.4
29sepsis10.4
30carpal tunnel syndrome10.3
31paraneoplastic polyneuropathy10.3
32osteosclerotic myeloma10.3
33hepatitis d10.3
34hepatitis a10.3
35beriberi10.2
36x-linked charcot-marie-tooth disease type 510.2
37ataxia10.2
38subacute inflammatory demyelinating polyneuropathy10.2
39polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract10.2
40axonal neuropathy10.1
41systemic lupus erythematosus10.1
42churg-strauss syndrome10.1
43acute leukemia10.1
44juvenile-onset small-fiber polyneuropathy10.1
45multifocal motor neuropathy10.1
46autonomic dysfunction10.1
47chronic pain10.1
48dysautonomia10.1
49hepatitis c virus10.1
50carpal tunnel syndrome, familial10.1

Graphical network of the top 20 diseases related to Polyneuropathy:



Diseases related to polyneuropathy

Clinical Features for Polyneuropathy

Drugs & Therapeutics for Polyneuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Polyneuropathy

Drug clinical trials:

Search ClinicalTrials for Polyneuropathy

Search NIH Clinical Center for Polyneuropathy

Search CenterWatch for Polyneuropathy

Genetic Tests for Polyneuropathy

Anatomical Context for Polyneuropathy

Animal Models for Polyneuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Polyneuropathy

Sources:
51PubMed
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Articles related to Polyneuropathy:

(show top 50)    (show all 1725)
idTitleAuthorsYear
1
Efficacy and safety of Privigen(Ar) in patients with chronic inflammatory demyelinating polyneuropathy: results of a prospective, single-arm, open-label Phase III study (the PRIMA study). (23781960)
2013
2
Electrophysiological features of taxane-induced polyneuropathy in patients with breast cancer. (23545771)
2013
3
A fatal case of seronegative, late-onset systemic lupus erythematosus presenting with motor sensory axonal polyneuropathy. (23397339)
2013
4
Winging scapula due to demyelinating polyneuropathy. (23055111)
2013
5
Diaphragmatic weakness with progressive sensory and motor polyneuropathy: case report of a neonatal IGHMBP2-related neuropathy. (22791546)
2013
6
Impairment of small somatic and autonomic nerve fibres in intensive care unit patients with severe sepsis and critical illness polyneuropathy - a single center controlled observational study. (24176121)
2013
7
A case of paraneoplastic demyelinating motor polyneuropathy. (22649345)
2012
8
Thermal threshold: research study on small fiber dysfunction in distal diabetic polyneuropathy. (22401337)
2012
9
Anti-myelin-associated glycoprotein polyneuropathy coexistent with CREST syndrome. (22387650)
2012
10
Prophylactic pacemaker implantation in familial amyloid polyneuropathy. (22387306)
2012
11
Atorvastatin treatment improves diabetic polyneuropathy electrophysiological changes in non-insulin dependent diabetic patients: a double blind, randomized clinical trial. (22691892)
2012
12
Clinical and electrophysiological signs of diabetic polyneuropathy -- effect of glycemia and duration of diabetes mellitus. (22263377)
2011
13
Central nervous system involvement in n-hexane polyneuropathy demonstrated by MRI and proton MR spectroscopy. (21349632)
2011
14
Recommendations for diabetic polyneuropathy treatment. (22263398)
2011
15
Ramsay Hunt syndrome with unilateral polyneuropathy involving cranial nerves V, VII, VIII, and XII in a diabetic patient. (22026001)
2011
16
Microvascular perfusion abnormalities of the Thalamus in painful but not painless diabetic polyneuropathy: a clue to the pathogenesis of pain in type 1 diabetes. (21282344)
2011
17
Chronic inflammatory demyelinating polyneuropathy disease activity status: recommendations for clinical research standards and use in clinical practice. (21199104)
2010
18
Management of critical illness polyneuropathy and myopathy. (20816273)
2010
19
Immunoglobulin M deposition in cutaneous nerves of anti-myelin-associated glycoprotein polyneuropathy patients correlates with axonal degeneration. (19151627)
2009
20
The significance of carpal tunnel syndrome in transthyretin Val30Met familial amyloid polyneuropathy. (19626479)
2009
21
Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy. (19771172)
2009
22
Derivation and validation of diagnostic criteria for chronic inflammatory demyelinating polyneuropathy. (19091330)
2009
23
Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analysis from an open-label, two-stage adaptive, randomized, controlled trial. (19301937)
2009
24
Polyneuropathy and cerebral infarction complicating scrub typhus. (19513323)
2008
25
Clinical characteristics of patients with diabetic polyneuropathy: the role of clinical and electromyographic evaluation and the effect of the various types on the quality of life. (18410351)
2008
26
Acute inflammatory demyelinating polyneuropathy and a unilateral babinski/plantar reflex. (20975794)
2008
27
Diagnosis and management of critical illness polyneuropathy and critical illness myopathy. (17298769)
2007
28
Relapse of chronic inflammatory demyelinating polyneuropathy 5 years after autologous stem cell transplantation. (17878198)
2007
29
Dispersion of compound muscle action potential in hereditary neuropathies and chronic inflammatory demyelinating polyneuropathy. (16823858)
2006
30
Progressive chronic inflammatory demyelinating polyneuropathy in a child with central nervous system involvement and myopathy. (17243577)
2006
31
Subacute demyelinating polyneuropathy in B-cell lymphoma with IgM antibodies against glycolipid GD1b. (16388373)
2005
32
Optimizing the use of electrophysiology in the diagnosis of chronic inflammatory demyelinating polyneuropathy: a study of 20 cases. (16221287)
2005
33
Acute inflammatory demyelinating polyneuropathy in patients with pregnancy. (15269509)
2004
34
Churg Strauss syndrome during treatment of bronchial asthma with a leucotriene receptor antagonist presenting with polyneuropathy. (15088164)
2004
35
Trovafloxacin-induced weakness due to a demyelinating polyneuropathy. (10832955)
2000
36
Matrix metalloproteinase upregulation in chronic inflammatory demyelinating polyneuropathy and nonsystemic vasculitic neuropathy. (10408538)
1999
37
Prednisone and plasma exchange improve suppressor cell function in chronic inflammatory demyelinating polyneuropathy. (10229130)
1999
38
Guillain-BarrAc polyneuropathy associated with mediterranean spotted fever: case report. (9868689)
1998
39
Intramyelinic edema in chronic inflammatory demyelinating polyneuropathy. (8998850)
1996
40
Chronic inflammatory demyelinating polyneuropathy associated with carcinoma. (8708651)
1996
41
Neuropathy target esterase (NTE) and organophosphorus-induced delayed polyneuropathy (OPIDP): recent advances. (8597094)
1995
42
Clinical examination versus neurophysiological examination in the diagnosis of diabetic polyneuropathy. (1395463)
1992
43
Familial amyloidotic polyneuropathy type 1 in Kumamoto, Japan: a clinicopathologic, histochemical, immunohistochemical, and ultrastructural study. (1864584)
1991
44
Acute polyneuropathy in critically ill patients. (2351777)
1990
45
Peripheral polyneuropathy during treatment with alpha-2 interferon. (1965833)
1990
46
The effect of pancreas transplantation on diabetic polyneuropathy. (3125636)
1988
47
Humoral abnormalities in three patients with idiopathic chronic polyneuropathy. (3895061)
1985
48
Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes: the POEMS syndrome. (7086810)
1982
49
Osteosclerotic "plasmocytoma" with polyneuropathy, hypertrichosis and diabetes. (645443)
1978
50
The genetic aspect of the familial amyloidotic polyneuropathy. Portuguese type of paramyloidosis. (5799493)
1969

Genetic Variations for Polyneuropathy

Expression for genes affiliated with Polyneuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyneuropathy

Search GEO for disease gene expression data for Polyneuropathy.

Pathways for genes affiliated with Polyneuropathy

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome
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Pathways related to Polyneuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6FCGR2B, CD28, TNF, IFNA2
210.6MPZ, MAG, CD28, CLDN5
310.6GDNF, MAG, AIF1, TNF
4
Hide members
10.5NGF, MAG

Compounds for genes affiliated with Polyneuropathy

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 11DrugBank, 50PharmGKB
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Compounds related to Polyneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1cysteine4511.3PMP22, TUBB, IFNA2, AKR1B1, MPZ, MAG
2lipid4511.3TUBB, IFNA2, TNF, MPZ, MAG, CNTF
3tyrosine4511.3TUBB, IFNA2, MPZ, AIRE, MAG, CNTF
4retinoic acid45 2412.3AIF1, TNF, IFNA2, PMP22, CNTF, NGF
5alanine4511.2TUBB, IFNA2, AKR1B1, MAG, CNTF, NGF
6serine4511.2FCGR2B, PMP22, TUBB, TNF, AKR1B1, MPZ
7genistein45 29 60 2 11 2416.2TNF, AKR1B1, CNTF, NGF, CD28, GDNF
8calcium45 50 11 2414.2CNTF, MAG, AIF1, TUBB, NGF, CD28
9aspartate4511.2PMP22, IFNA2, MPZ, MAG, GDNF, TTR
10adenylate4511.2TUBB, AKR1B1, CNTF, NGF, GDNF, TTR
11thymidine45 2412.2TUBB, IFNA2, TNF, MAG, CNTF, NGF
12ganglioside4511.1PMP22, MPZ, MAG, CNTF, NGF, GDNF
13ascorbic acid45 2412.1PMP22, IFNA2, AKR1B1, MAG, CNTF, TTR
14methionine4511.1TUBB, IFNA2, MPZ, CNTF, TTR, GSN
15phosphatidylinositol4511.1TUBB, CNTF, NGF, CD28, GDNF, FCGR2B
16dopamine45 29 11 2414.1IFNA2, CNTF, NGF, GDNF, TTR, GSN
17superoxide45 2412.1IFNA2, TNF, CNTF, GDNF, FCGR2B, GSN
18dihydrotestosterone45 29 11 2414.1GSN, NGF, MPZ, AKR1B1, PMP22
19bromodeoxyuridine4511.1TUBB, MPZ, AIF1, CNTF, GDNF
20creatinine4511.1AKR1B1, MPZ, NGF, GDNF, TTR
21testosterone45 60 11 2414.0TUBB, AKR1B1, CNTF, NGF, TTR, GSN
22phosphotyrosine4511.0TUBB, MAG, NGF, CD28, GSN
23histamine45 29 2413.0FCGR2B, NGF, CNTF, TNF, IFNA2
24rituximab45 50 1113.0IFNA2, TNF, MAG, FCGR2B
25oxygen45 2412.0TNF, AKR1B1, CD28, GDNF, GSN
26ly2940024511.0GDNF, CD28, NGF, CNTF, TNF
27wortmannin4511.0CNTF, NGF, CD28, GDNF, GSN
28actinomycin d4511.0GDNF, NGF, CNTF, AKR1B1, TNF
29forskolin45 50 1113.0GDNF, NGF, CNTF, TUBB, PMP22
30glutamate4511.0GSN, GDNF, CNTF
31norepinephrine45 11 2413.0CNTF, GDNF, TTR
32vegf4510.9IFNA2, TNF, AKR1B1, CNTF, NGF, GDNF
33arginine4510.9PMP22, AKR1B1, MPZ, CNTF, NGF, TTR
34cyclosporin a45 29 6012.9AKR1B1, NGF, CD28, TTR
353-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4510.9TUBB, IFNA2, NGF
36valine4510.9TTR, NGF, IFNA2, TUBB
37etanercept45 50 1112.9IFNA2, TNF, FCGR2B
38ceramide4510.9TNF, NGF, CD1D, CD28
39alpha lipoic acid4510.9NGF, AKR1B1, TNF
40glycerol45 11 2412.9TUBB, AKR1B1, NGF, TTR
41threonine4510.9TUBB, MAG, CNTF, NGF, CD28, TTR
42glycolipid4510.8CD1D, MAG, MPZ
43ivig4510.8TNF, MAG, FCGR2B
44capsaicin45 2911.7GDNF, NGF, AKR1B1
45melphalan45 1111.7TTR, TNF, IFNA2
46gaba4510.7PMP22, TUBB, CNTF, GDNF
47neopterin4510.6TTR, TNF, IFNA2
48indomethacin45 60 29 1113.6NGF, AKR1B1
49epinephrine45 11 2412.5IFNA2, AKR1B1, NGF, TTR
50cyclic amp45 2411.3GDNF, CD28, NGF, CNTF, MAG

GO Terms for genes affiliated with Polyneuropathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.8TNF, AKR1B1, CNTF, NGF, DHH, TTR
2phagocytic cupGO:00189110.5TNF, AIF1
3paranode region of axonGO:03327010.5CLDN5, MAG
4plasma membraneGO:00588610.5PMP22, TUBB, TNF, MPZ, AIRE, MAG
5Schmidt-Lanterman incisureGO:04322010.4MAG, CLDN5

Biological processes related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1humoral immune responseGO:00695910.6CD28, AIRE, TNF
2apoptotic signaling pathwayGO:09719010.6CD28, NGF, TNF
3positive regulation of T cell proliferationGO:04210210.6CD1D, CD28, AIF1
4negative regulation of neuron apoptotic processGO:04352410.5CNTF, NGF, GDNF
5inflammatory responseGO:00695410.3NGF, IFNA2, TNF, AIF1

Molecular functions related to Polyneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.6TTR, CLDN5, CD28, AIRE, TNF

Products for genes affiliated with Polyneuropathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Polyneuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet