MCID: PLY100
MIFTS: 33

Polyploidy malady

Fetal diseases category

Summaries for Polyploidy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Polyploid cells and organisms are those containing more than two paired (homologous) sets of... more...

MalaCards: Polyploidy is related to leukemia and breast cancer. An important gene associated with Polyploidy is AURKC (aurora kinase C), and among its related pathways are Apoptosis Modulation and Signaling and Aurora C signaling. The compounds N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine and paclitaxel have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and cellular.

Aliases & Classifications for Polyploidy

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Sources:
48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

polyploidy 48 60


External Ids:

MESH via Orphanet35 D011123
ICD10 via Orphanet26 Q92.7
SNOMED-CT via Orphanet57 48099008, 72991005
UMLS via Orphanet61 C0032578

Related Diseases for Polyploidy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Polyploidy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.4CCNA1, CASP2, IRF2, PIM1, ENDOG, SKP2
2breast cancer30.2BUB1, NAMPT, IRF2, AURKB, SKP2, NEK2
3melanoma30.0TBX2, SKP2, PIM1, CASP2
4myeloid leukemia29.8CCNA1, PIM1
5glioblastoma multiforme29.8SKP2
6acute myeloid leukemia29.8CCNA1
7hypertension10.4
8hepatitis10.2
9acute leukemia10.1
10triploidy10.1
11tetraploidy10.1
12choroid plexus papilloma10.0
13rosacea10.0
14choroiditis10.0
15atypical choroid plexus papilloma10.0
16neuronitis10.0
17hepatitis b10.0
18chromosomal disease10.0
19papilloma10.0
20oral cancer10.0SKP2
21laryngeal squamous cell carcinoma10.0SKP2
22ovarian cancer10.0CCNE1, SKP2
23osteosarcoma10.0ENDOG, CCNA1
24astrocytoma10.0CASP2
25hepatocellular carcinoma10.0SKP2, BUB1, AURKB, CCNE1
26retinoblastoma10.0CCNA1, CCNE1, AURKB, SKP2
27prostate cancer10.0PIM1, SKP2, CASP2
28burkitt's lymphoma10.0CCNE1, BUB1, SKP2, PIM1, CASP2
29megakaryocytic leukemia9.9
30pigmented villonodular synovitis9.9
31pleomorphic adenoma9.9
32hepatitis c9.9
33incontinentia pigmenti achromians9.9
34megakaryocytic tumor9.9
35villonodular synovitis9.9
36malignant histiocytosis9.9
37polycystic kidney disease9.9
38mantle cell lymphoma9.9
39adenocarcinoma9.9
40adenoma9.9
41arthritis9.9
42chronic lymphocytic leukemia9.9
43fibrosarcoma9.9
44histiocytosis9.9
45hodgkin's lymphoma9.9
46kidney disease9.9
47lipodystrophy9.9
48lung cancer9.9
49myelofibrosis9.9
50myeloma9.9

Graphical network of the top 20 diseases related to Polyploidy:



Diseases related to polyploidy

Clinical Features for Polyploidy

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Drugs & Therapeutics for Polyploidy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Polyploidy

Drug clinical trials:

Search ClinicalTrials for Polyploidy

Search NIH Clinical Center for Polyploidy

Search CenterWatch for Polyploidy

Genetic Tests for Polyploidy

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Anatomical Context for Polyploidy

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Animal Models for Polyploidy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Polyploidy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.9CCNE1, CASP2, AURKC, AURKB, BUB1, SKP2
2MP:00053849.5AURKB, SKP2, NAMPT, BUB3, BUB1, PIM1
3MP:00053979.5CCNA1, CCNE1, CASP2, IRF2, PIM1, BUB1
4MP:00107689.3ENDOG, CCNA1, INCENP, NAMPT, BUB3, BUB1

Publications for Polyploidy

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Genetic Variations for Polyploidy

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Expression for genes affiliated with Polyploidy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyploidy

Search GEO for disease gene expression data for Polyploidy.

Pathways for genes affiliated with Polyploidy

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Sources:
37NCBI BioSystems Database, 55SinoBiological, 51QIAGEN, 29KEGG, 12EMD Millipore, 53Reactome, 4Cell Signaling Technology
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Pathways related to Polyploidy according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2ENDOG, IRF2, CASP2
2
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10.2INCENP, AURKB, AURKC
3
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10.2CCNE1, CASP2, PSMB5
4
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10.2BUB1, CCNE1, CCNA1
510.2INCENP, AURKB, CCNA1
610.2AURKB, NEK2, SKP2
7
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10.2SKP2, CCNE1, CCNA1
8
Cell cycle Cell cycle (generic schema)
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10.2CCNA1, CCNE1, SKP2
910.1INCENP, BUB1, AURKB, AURKC
10
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10.1AURKB, BUB1, BUB3, INCENP
11
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10.1SKP2, PSMB5, CCNE1, CCNA1
12
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10.0AURKB, PSMB5, BUB1, BUB3, INCENP
13
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10.0SKP2, PSMB5, CASP2, CCNE1, CCNA1
14
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10.0CCNA1, CCNE1, BUB1, BUB3, SKP2
15
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9.9CCNE1, AURKC, AURKB, BUB3, INCENP, SKP2
169.9CCNA1, AURKB, NEK2, BUB1, BUB3, SKP2
17
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9.8CCNA1, CCNE1, AURKB, PSMB5, BUB3, GINS2
18
Hide members
9.5SKP2, CCNA1, CCNE1, AURKB, PSMB5, NEK2

Compounds for genes affiliated with Polyploidy

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Sources:
11DrugBank, 44Novoseek, 49PharmGKB
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Compounds related to Polyploidy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine1110.3INCENP, AURKB
2paclitaxel44 49 1112.2ENDOG, INCENP
3threonine4410.0INCENP, NEK2, PIM1, AURKB, CASP2
4serine449.5CCNE1, CASP2, AURKB, IRF2, PIM1, NEK2

GO Terms for genes affiliated with Polyploidy

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Sources:
16Gene Ontology
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Cellular components related to Polyploidy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromosome passenger complexGO:03213310.4AURKB, AURKC
2chromocenterGO:01036910.4AURKB, INCENP
3condensed nuclear chromosome, centromeric regionGO:00078010.3BUB1, AURKB
4midbodyGO:03049610.3AURKC, AURKB, NEK2, INCENP
5kinetochoreGO:00077610.3INCENP, BUB3, BUB1, NEK2
6condensed chromosome kinetochoreGO:00077710.2INCENP, BUB3, BUB1, NEK2
7spindleGO:0058199.9INCENP, AURKB, AURKC
8nucleoplasmGO:0056549.8CCNE1, CCNA1, SKP2, GINS2, PSMB5, IRF2
9nucleusGO:0056349.5BUB3, TBX2, STRADB, CASP2, PIM1, PPP1R8
10cytosolGO:0058299.4SKP2, CCNE1, CASP2, AURKB, IRF2, PSMB5

Biological processes related to Polyploidy according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1histone modificationGO:01657010.5AURKB, AURKC
2regulation of chromosome segregationGO:05198310.5AURKB, BUB1, BUB3
3spindle assembly checkpointGO:07117310.5BUB3, BUB1
4attachment of spindle microtubules to kinetochoreGO:00860810.5BUB3, AURKB, AURKC
5spindle midzone assembly involved in mitosisGO:05125610.5AURKB, AURKC
6mitotic spindle assembly checkpointGO:00709410.5BUB3, BUB1, PSMG2
7meiosisGO:00712610.4AURKC, NEK2, BUB3
8anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processGO:03114510.4AURKB, PSMB5, BUB3, SKP2
9chromosome segregationGO:00705910.3NEK2, BUB1, INCENP
10positive regulation of cytokinesisGO:03246710.3AURKC, AURKB
11G1/S transition of mitotic cell cycleGO:00008210.3SKP2, PSMB5, CCNE1, CCNA1
12regulation of transcription involved in G1/S transition of mitotic cell cycleGO:00008310.3CCNE1, CCNA1
13cell divisionGO:05130110.3CCNA1, CCNE1, NEK2, BUB1, BUB3
14protein phosphorylationGO:00646810.2CCNE1, AURKC, AURKB, PIM1, STRADB, NEK2
15cell proliferationGO:00828310.2BUB1, PIM1, PPP1R8, IRF2, AURKB, SKP2
16mitosisGO:00706710.2CCNA1, NEK2, BUB1, INCENP
17apoptotic processGO:00691510.1BUB1, PIM1, PSMG2, PSMB5, CASP2
18G2/M transition of mitotic cell cycleGO:00008610.1SKP2, NEK2, CCNA1
19mitotic sister chromatid segregationGO:00007010.0BUB3, NEK2
20mitotic cell cycleGO:0002789.8SKP2, CCNA1, CCNE1, AURKB, PSMB5, NEK2

Molecular functions related to Polyploidy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein serine/threonine/tyrosine kinase activityGO:00471210.3AURKB, AURKC
2protein serine/threonine kinase activityGO:00467410.0BUB1, NEK2, PIM1, AURKB, AURKC
3protein kinase activityGO:0046729.8AURKC, STRADB, NEK2, BUB1
4protein bindingGO:0055158.8CCNA1, BUB1, TBX2, NEK2, STRADB, PIM1

Products for genes affiliated with Polyploidy

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Sources for Polyploidy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet