MCID: PLY100
MIFTS: 43

Polyploidy malady

Fetal diseases, Rare diseases categories
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Summaries for Polyploidy

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65Wikipedia, 33MalaCards
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Wikipedia:65 Polyploid cells and organisms are those containing more than two paired (homologous) sets of... more...

MalaCards: Polyploidy is related to breast cancer and melanoma. An important gene associated with Polyploidy is AURKC (aurora kinase C), and among its related pathways are Aurora B signaling and Cell cycle Spindle assembly and chromosome separation. The compounds adpribose and 5fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, liver and breast, and related mouse phenotype reproductive system.

Aliases & Classifications for Polyploidy

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49Orphanet, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Rare diseases


Aliases & Descriptions:

polyploidy 49 62


External Ids:

MESH via Orphanet36 D011123
ICD10 via Orphanet26 Q92.7
SNOMED-CT via Orphanet59 48099008, 72991005
UMLS via Orphanet63 C0032578

Related Diseases for Polyploidy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Polyploidy:



Diseases related to polyploidy

Symptoms for Polyploidy

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Drugs & Therapeutics for Polyploidy

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Polyploidy

Search NIH Clinical Center for Polyploidy

Genetic Tests for Polyploidy

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Anatomical Context for Polyploidy

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33MalaCards
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MalaCards organs/tissues related to Polyploidy:

33
Smooth muscle, Liver, Breast, Heart, Testes, Cerebellum, Bone marrow, Lung, Colon, Ovary, Bone, Myeloid, Cardiac myocytes, Prostate, Salivary gland, Pancreas, Endothelial, B cells, Thyroid

Animal Models for Polyploidy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Polyploidy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.4CASP2, AURKB, AURKC, TERC

Publications for Polyploidy

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52PubMed
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Articles related to Polyploidy:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal. (24025698)
2013
2
Comparative genomics suggests that an ancestral polyploidy event leads to enhanced root nodule symbiosis in the Papilionoideae. (24008584)
2013
3
Development of polyploidy of scale-building cells in the wings of Manduca sexta. (23017249)
2013
4
The more the merrier: recent hybridization and polyploidy in cardamine. (24082009)
2013
5
Single copy nuclear gene analysis of polyploidy in wild potatoes (Solanum section Petota). (22624678)
2012
6
Developmental regulation of decidual cell polyploidy at the site of implantation. (22652887)
2012
7
Is polyploidy a persevering accident or an adaptive evolutionary pattern? The case of the brine shrimp Artemia. (21145977)
2011
8
Polyploidy and ecological transfiguration in Achillea. (21498691)
2011
9
Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy. (20304929)
2010
10
Polyploidy in atypical grade II choroid plexus papilloma of the posterior fossa. (18627486)
2009
11
The allotetraploid Arabidopsis thaliana-Arabidopsis lyrata subsp. petraea as an alternative model system for the study of polyploidy in plants. (19148683)
2009
12
Multiple dicentric chromosomes behind polyploidy in grade II atypical choroid plexus papilloma: a complementary cytogenetic evaluation. (19077039)
2009
13
Influence of polyploidy on insect herbivores of native and invasive genotypes of Solidago gigantea (Asteraceae). (19938375)
2009
14
Locating large-scale gene duplication events through reconciled trees: implications for identifying ancient polyploidy events in plants. (19689214)
2009
15
Spindle positioning, meiotic nonreduction, and polyploidy in plants. (19043552)
2008
16
Evolution of polyploidy and the diversification of plant-pollinator interactions. (18724730)
2008
17
Pim-1 induced polyploidy but did not affect megakaryocytic differentiation of K562 cells and CD34+ cells from cord blood. (17313559)
2007
18
Roles of dynamic and reversible histone acetylation in plant development and polyploidy. (17556080)
2007
19
Hybridization, polyploidy, and the evolution of sexual systems in Mercurialis (Euphorbiaceae). (17089965)
2006
20
Polyploidy, evolutionary opportunity, and crop adaptation. (15881691)
2005
21
p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells. (15735758)
2005
22
Induction of cell proliferation, micronuclei and hyperdiploidy/polyploidy in the mammary cells of DDT- and DMBA-treated pubertal rats. (15880734)
2005
23
From polyploidy to aneuploidy, genome instability and cancer. (14708009)
2004
24
Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins. (14973072)
2004
25
Breaking down taxonomic barriers in polyploidy research. (14659707)
2003
26
Evolution of clonality and polyploidy in a weevil system. (12885970)
2003
27
Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. (12447394)
2002
28
Hepatic polyploidy and liver growth control. (10936066)
2000
29
Polyploidy in a natural population of mussel, Mytilus trossulus. (10791832)
2000
30
Relationship between polyploidy and pollen self-incompatibility phenotype in Petunia hybrida Vilm. (10635553)
1999
31
Dolastatin-10 induces polyploidy, telomeric associations and apoptosis in a murine melanoma cell line. (9468560)
1998
32
Cytoskeleton and polyploidy after maturation and fertilization of cryopreserved germinal vesicle-stage mouse oocytes. (9717122)
1998
33
Polyploidy and failed fertilization in in-vitro fertilization are related to patient's age and gamete quality. (8671278)
1996
34
Polyploidy in cardiac myocytes of normal and hypertrophic human hearts; range of values. (8205355)
1994
35
Induced diploid gynogenesis and polyploidy in the ornamental (koi) carp Cyprinus carpio L. : 3. Optimization of heat-shock timing during the 2nd meiotic division and the 1st cleavage. (24177842)
1994
36
Association of ultrarapid freezing of mouse oocytes with increased polyploidy at the pronucleate stage, reduced cell numbers in blastocysts and impaired fetal development. (8283446)
1993
37
Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment. (1659821)
1991
38
Induction of sister-chromatid exchanges (SCE), polyploidy, and micronuclei by plant flavonoids in human lymphocyte cultures. A comparative study of 19 flavonoids. (1986264)
1991
39
Endoreduplication and polyploidy in fragile X cells induced by methotrexate and fluorodeoxyuridine: implications for diagnosis. (1826810)
1991
40
Repetitive DNA and polyploidy in selachians. (7151416)
1982
41
Polyploidy in plants: unsolved problems and prospects. (550840)
1979
42
Polyploidy in plant taxa: summary. (550828)
1979
43
Polyploidy in bryophytes with special emphasis on mosses. (550824)
1979
44
Razoxane-induced polyploidy. (687512)
1978
45
Cell polyploidy: its relation to tissue growth and function. (332657)
1977
46
An example of polyploidy in pig blastocysts. (1195246)
1975
47
Hybridity, polyploidy and change in breeding system in a Ruellia hybrid. (24435332)
1969
48
Polyploidy and maturation of rat megakaryocytes. (5690593)
1968
49
Mitosis and polyploidy in nuclei of Opalina ranarum. (4971621)
1968
50
Cell size, nuclear content, and the development of polyploidy in the Mammalian liver. (16591473)
1967

Variations for Polyploidy

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Expression for genes affiliated with Polyploidy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyploidy

Search GEO for disease gene expression data for Polyploidy.

Pathways for genes affiliated with Polyploidy

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters
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Pathways related to Polyploidy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases38
Aurora C signaling38
9.6AURKB, AURKC
29.5NEK2, AURKB
39.5NEK2, AURKB
49.5NEK2, AURKB

Compounds for genes affiliated with Polyploidy

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR
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Compounds related to Polyploidy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1adpribose459.4CASP2, TERC
25fluorouracil459.3CASP2, TERC
3magnesium45 24 1111.1NEK2, AURKB, TERC
4adp45 29 2411.0AURKC, AURKB, NEK2
5threonine458.9CASP2, NEK2, AURKB
6Adenosine triphosphate24 119.8NEK2, AURKB, AURKC

GO Terms for genes affiliated with Polyploidy

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16Gene Ontology
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Cellular components related to Polyploidy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromosome passenger complexGO:0321339.6AURKB, AURKC
2spindleGO:0058199.6AURKB, AURKC
3intercellular bridgeGO:0451719.4AURKB, NEK2
4midbodyGO:0304969.1NEK2, AURKB, AURKC
5nucleusGO:0056347.0AURKC, AURKB, NEK2, IL17RD, CASP2, TBX2

Biological processes related to Polyploidy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1histone modificationGO:0165709.8AURKB, AURKC
2spindle midzone assembly involved in mitosisGO:0512569.7AURKB, AURKC
3attachment of spindle microtubules to kinetochoreGO:0086089.7AURKB, AURKC
4positive regulation of cytokinesisGO:0324679.6AURKB, AURKC
5meiotic nuclear divisionGO:0071269.5NEK2, AURKC
6protein autophosphorylationGO:0467779.5NEK2, AURKB
7protein phosphorylationGO:0064689.1AURKC, AURKB, NEK2
8agingGO:0075689.0CASP2, AURKB

Molecular functions related to Polyploidy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase activityGO:0046729.6NEK2, AURKC
2protein serine/threonine/tyrosine kinase activityGO:0047129.5AURKB, AURKC
3protein serine/threonine kinase activityGO:0046748.8NEK2, AURKB, AURKC

Products for genes affiliated with Polyploidy

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Sources for Polyploidy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet