MCID: PLY100
MIFTS: 45

Polyploidy malady

Fetal category

Summaries for Polyploidy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Polyploid cells and organisms are those containing more than two paired (homologous) sets of... more...

MalaCards: Polyploidy is related to acute myeloid leukemia and hepatitis c. An important gene associated with Polyploidy is AURKC (aurora kinase C), and among its related pathways are Apoptosis Modulation and Signaling and Aurora C signaling. The compounds N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine and paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and kidney, and related mouse phenotypes are reproductive system and cellular.

Aliases & Classifications for Polyploidy

Sources:
49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal


Aliases & Descriptions:

polyploidy 49 61


External Ids:

MESH via Orphanet36 D011123
ICD10 via Orphanet26 Q92.7
SNOMED-CT via Orphanet58 48099008, 72991005
UMLS via Orphanet62 C0032578

Related Diseases for Polyploidy

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Polyploidy:



Diseases related to polyploidy

Clinical Features for Polyploidy

Drugs & Therapeutics for Polyploidy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Polyploidy

Drug clinical trials:

Search ClinicalTrials for Polyploidy

Search NIH Clinical Center for Polyploidy

Search CenterWatch for Polyploidy

Genetic Tests for Polyploidy

Anatomical Context for Polyploidy

Sources:
33MalaCards
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MalaCards organs/tissues related to Polyploidy:

33
Ovary, Liver, Kidney, Lung, Bone marrow, Whole blood, Cerebellum, Heart, Smooth muscle, Small intestine, Colon, Pancreas, Thyroid, Salivary gland, Breast, Prostate, Myeloid, T cells, B lymphoblasts, B cells, Endothelial, Cardiac myocytes, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet

Animal Models for Polyploidy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Polyploidy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.9CCNE1, CASP2, AURKC, AURKB, BUB1, SKP2
2MP:00053849.5AURKB, SKP2, NAMPT, BUB3, BUB1, PIM1
3MP:00053979.5CCNA1, CCNE1, CASP2, IRF2, PIM1, BUB1
4MP:00107689.3ENDOG, CCNA1, INCENP, NAMPT, BUB3, BUB1

Publications for Polyploidy

Sources:
51PubMed
See all sources

Articles related to Polyploidy:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
The more the merrier: recent hybridization and polyploidy in cardamine. (24082009)
2013
2
Polyploidy in myelofibrosis: analysis by cytogenetic and SNP array indicates association with advancing disease. (24341401)
2013
3
Revisiting the dioecy-polyploidy association: alternate pathways and research opportunities. (23838528)
2013
4
Natural pathways towards polyploidy in animals: the Squalius alburnoides fish complex as a model system to study genome size and genome reorganization in polyploids. (23796598)
2013
5
Why comparing polyploidy research in animals and plants? (23899808)
2013
6
Flow cytometric analysis of somaclonal variation in lineages of Hosta sports detects polyploidy and aneuploidy chimeras. (22676855)
2012
7
The organisation of Ebola virus reveals a capacity for extensive, modular polyploidy. (22247782)
2012
8
Polyploidy and liver proliferation. (21778131)
2012
9
Polyploidy associated with altered and broader ecological niches in the Claytonia perfoliata (Portulacaceae) species complex. (22434773)
2012
10
Polyploidy-induction by dihydroxylated monochlorobiphenyls: structure-activity-relationships. (20471090)
2010
11
Hybridization and polyploidy as drivers of continuing evolution and speciation in Sorbus. (20345692)
2010
12
Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy. (20473324)
2010
13
Hybridization and polyploidy of an aquatic plant, Ruppia (Ruppiaceae), inferred from plastid and nuclear DNA phylogenies. (21616867)
2010
14
Molecular alterations at 9q33.1 and polyploidy in asbestos-related lung cancer. (19147751)
2009
15
Spindle positioning, meiotic nonreduction, and polyploidy in plants. (19043552)
2008
16
Ectopic Tbx2 expression results in polyploidy and cisplatin resistance. (17700536)
2008
17
Microsatellite development suggests evidence of polyploidy in the social sponge-dwelling snapping shrimp Zuzalpheus brooksi. (21585921)
2008
18
Genetic stability of senescence reverted cells: genome reduction division of polyploidy cells, aneuploidy and neoplasia. (18469530)
2008
19
53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy. (17452983)
2007
20
Oxalis debilis in China: distribution of flower morphs, sterile pollen and polyploidy. (16735406)
2006
21
Polyploidy, evolutionary opportunity, and crop adaptation. (15881691)
2005
22
Enforced adhesion of hematopoietic cells to culture dish induces endomitosis and polyploidy. (15908784)
2005
23
The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression. (16258285)
2005
24
Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy. (15917996)
2005
25
Induction of polyploidy by histone deacetylase inhibitor: a pathway for antitumor effects. (16140952)
2005
26
Molecular evidence for asymmetric evolution of sister duplicated blocks after cereal polyploidy. (16217602)
2005
27
Evolution by polyploidy and gene regulation in Anura. (15266394)
2004
28
A recent polyploidy superimposed on older large-scale duplications in the Arabidopsis genome. (12566392)
2003
29
Familial sperm polyploidy induced by genetic spermatogenesis failure: case report. (11726589)
2001
30
Polyploidy in acute promyelocytic leukemia without the 15:17 translocation. (11726325)
2001
31
Hepatic polyploidy and liver growth control. (10936066)
2000
32
Molecular basis to understand polyploidy. (10543372)
1999
33
Noscapine hydrochloride disrupts the mitotic spindle in mammalian cells and induces aneuploidy as well as polyploidy in cultured human lymphocytes. (10474821)
1999
34
Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1, leads to aneuploidy and polyploidy. (10468586)
1999
35
Genetic redundancy in vertebrates: polyploidy and persistence of genes encoding multidomain proteins. (9520595)
1998
36
Plant polyploidy and insect/plant interactions. (18811333)
1997
37
Alterations in beta-adrenoceptors and polyploidy in cultured aortic smooth muscle cells from different age groups of spontaneously hypertensive rats and Wistar-Kyoto rats. (7561007)
1995
38
Endoreduplication and polyploidy in fragile X cells induced by methotrexate and fluorodeoxyuridine: implications for diagnosis. (1826810)
1991
39
Does smooth muscle cell polyploidy occur in resistance vessels of spontaneously hypertensive rats? (3345353)
1988
40
The effect of polyploidy on embryo cleavage after in vitro fertilization in humans. (3653419)
1987
41
Polyploidy in mammalian urothelial cells. (7423695)
1980
42
Polyploidy in the australian leptodactylid frog genus Neobatrachus. (7192202)
1980
43
Polyploidy and domestication: the origin and survival of polyploids in cytotype mixtures. (550834)
1979
44
Cell polyploidy: its relation to tissue growth and function. (332657)
1977
45
Facultative polyploidy in endocrine tissues. (413255)
1977
46
Rapid determination of polyploidy in human chorionic tissue sections. (885550)
1977
47
Polyploidy in the human myometrium. (1199401)
1975
48
The biochemistry of differentiation of mouse trophoblast: studies on polyploidy. (5061668)
1972
49
Cytogenetical relationships between Rumex tuberosus, R. thyrsiflorus and R. acetosa and occurrence of polyploidy among their hybrids. (24430189)
1970
50
Biochemical correlates of cardiac hypertrophy. 3. Changes in DNA content; the relative contributions of polyploidy and mitotic activity. (4242254)
1969

Genetic Variations for Polyploidy

Expression for genes affiliated with Polyploidy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyploidy

Search GEO for disease gene expression data for Polyploidy.

Pathways for genes affiliated with Polyploidy

Sources:
38NCBI BioSystems Database, 56SinoBiological, 52QIAGEN, 30KEGG, 12EMD Millipore, 54Reactome, 4Cell Signaling Technology
See all sources

Pathways related to Polyploidy according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CASP2, IRF2, ENDOG
2
Hide members
10.2AURKB, INCENP, AURKC
3
Hide members
10.2CASP2, CCNE1, PSMB5
4
Hide members
10.2CCNA1, CCNE1, BUB1
510.2CCNA1, INCENP, AURKB
610.2SKP2, NEK2, AURKB
7
Hide members
10.2SKP2, CCNE1, CCNA1
8
Cell cycle Cell cycle (generic schema)
Hide members
10.2CCNA1, CCNE1, SKP2
910.1INCENP, BUB1, AURKB, AURKC
10
Hide members
10.1AURKB, BUB1, INCENP, BUB3
11
Hide members
10.1CCNE1, CCNA1, PSMB5, SKP2
12
Hide members
10.0AURKB, PSMB5, BUB1, BUB3, INCENP
13
Hide members
10.0CCNA1, SKP2, PSMB5, CASP2, CCNE1
14
Hide members
10.0SKP2, BUB3, BUB1, CCNE1, CCNA1
15
Hide members
9.9CCNE1, AURKC, AURKB, BUB3, INCENP, SKP2
169.9CCNA1, NEK2, BUB1, BUB3, SKP2, AURKB
17
Hide members
9.8PSMB5, BUB3, GINS2, SKP2, AURKB, CCNE1
18
Hide members
9.5SKP2, CCNA1, CCNE1, AURKB, PSMB5, NEK2

Compounds for genes affiliated with Polyploidy

Sources:
11DrugBank, 45Novoseek, 50PharmGKB
See all sources

Compounds related to Polyploidy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine1110.3AURKB, INCENP
2paclitaxel45 50 1112.2INCENP, ENDOG
3threonine4510.0CASP2, AURKB, PIM1, NEK2, INCENP
4serine459.5ENDOG, CCNE1, CASP2, AURKB, IRF2, INCENP

GO Terms for genes affiliated with Polyploidy

Sources:
16Gene Ontology
See all sources

Cellular components related to Polyploidy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromosome passenger complexGO:03213310.4AURKB, AURKC
2chromocenterGO:01036910.4AURKB, INCENP
3condensed nuclear chromosome, centromeric regionGO:00078010.3BUB1, AURKB
4midbodyGO:03049610.3AURKC, AURKB, NEK2, INCENP
5kinetochoreGO:00077610.3INCENP, BUB3, BUB1, NEK2
6condensed chromosome kinetochoreGO:00077710.2INCENP, BUB3, BUB1, NEK2
7spindleGO:0058199.9INCENP, AURKB, AURKC
8nucleoplasmGO:0056549.8CCNE1, CCNA1, SKP2, GINS2, PSMB5, IRF2
9nucleusGO:0056349.5BUB3, TBX2, STRADB, CASP2, PIM1, PPP1R8
10cytosolGO:0058299.4SKP2, CCNE1, CASP2, AURKB, IRF2, PSMB5

Biological processes related to Polyploidy according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1histone modificationGO:01657010.5AURKB, AURKC
2regulation of chromosome segregationGO:05198310.5AURKB, BUB1, BUB3
3spindle assembly checkpointGO:07117310.5BUB3, BUB1
4attachment of spindle microtubules to kinetochoreGO:00860810.5BUB3, AURKB, AURKC
5spindle midzone assembly involved in mitosisGO:05125610.5AURKB, AURKC
6mitotic spindle assembly checkpointGO:00709410.5BUB3, BUB1, PSMG2
7meiosisGO:00712610.4AURKC, NEK2, BUB3
8anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processGO:03114510.4AURKB, PSMB5, BUB3, SKP2
9chromosome segregationGO:00705910.3NEK2, BUB1, INCENP
10positive regulation of cytokinesisGO:03246710.3AURKC, AURKB
11G1/S transition of mitotic cell cycleGO:00008210.3SKP2, PSMB5, CCNE1, CCNA1
12regulation of transcription involved in G1/S transition of mitotic cell cycleGO:00008310.3CCNE1, CCNA1
13cell divisionGO:05130110.3CCNA1, CCNE1, NEK2, BUB1, BUB3
14protein phosphorylationGO:00646810.2CCNE1, AURKC, AURKB, PIM1, STRADB, NEK2
15cell proliferationGO:00828310.2BUB1, PIM1, PPP1R8, IRF2, AURKB, SKP2
16mitosisGO:00706710.2CCNA1, NEK2, BUB1, INCENP
17apoptotic processGO:00691510.1BUB1, PIM1, PSMG2, PSMB5, CASP2
18G2/M transition of mitotic cell cycleGO:00008610.1SKP2, NEK2, CCNA1
19mitotic sister chromatid segregationGO:00007010.0BUB3, NEK2
20mitotic cell cycleGO:0002789.8SKP2, CCNA1, CCNE1, AURKB, PSMB5, NEK2

Molecular functions related to Polyploidy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein serine/threonine/tyrosine kinase activityGO:00471210.3AURKB, AURKC
2protein serine/threonine kinase activityGO:00467410.0BUB1, NEK2, PIM1, AURKB, AURKC
3protein kinase activityGO:0046729.8AURKC, STRADB, NEK2, BUB1
4protein bindingGO:0055158.8CCNA1, BUB1, TBX2, NEK2, STRADB, PIM1

Products for genes affiliated with Polyploidy

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Sources for Polyploidy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet