Polyposis malady

MalaCards: Polyposis, also known as multiple polyps, is related to familial adenomatous polyposis and adenomatous polyposis coli. An important gene associated with Polyposis is APC (adenomatous polyposis coli), and among its related pathways are Wnt signaling pathway and WNT Signaling. The compounds estrogen and progesterone have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and lung, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

polyposis 7 32 multiple polyps 43

Diseases related to polyposis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 956)

id	Related Disease	Score	Top Affiliating Genes
1	familial adenomatous polyposis	61.2	PIN1, KLF4, KLF6, REEP5, KIF3A, PCNA
2	adenomatous polyposis coli	54.1	PIH1D1, PIK3CG, KLF4, REEP5, KIFAP3, KIF2C
3	carcinoma	48.0	PIK3CG, PIN1, KLF4, KLF6, PDCD1, REEP5
4	colon cancer	43.1	PIK3CG, KLF4, KLF6, REEP6, RELA, PCBD1
5	adenoma	43.0	KLF4, KITLG, SFRP1, PCNA, RB1, VIM
6	gastric cancer	40.2	PIK3CG, PIN1, KLF4, KLF6, RELA, KIF2C
7	adenocarcinoma	39.7	PIK3CG, PIN1, KLF4, KLF6, RELA, KITLG
8	prostatitis	38.5	PIK3CG, PIN1, KLF4, KLF6, PDCD1, RELA
9	colorectal cancer	38.2	NAT1, NAT2, VDR, UGT1A1, MSH2, MLH1
10	neuronitis	37.5	PIK3CG, PIN1, KLF4, KLF6, RELA, KIFAP3
11	pancreatitis	37.1	PIK3CG, PIN1, KLF4, KLF6, RELA, KITLG
12	juvenile polyposis syndrome	36.5	BMP2, BMPR1A, APC, DUSP13, PTEN, PTGS2
13	hepatocellular carcinoma	36.4	PIK3CG, PIN1, KLF6, PDCD1, RELA, SFRP1
14	thyroiditis	36.3	PIK3CG, PIN1, KLF4, RELA, KITLG, PCNA
15	colon carcinoma	35.9	PIK3CG, KLF4, KITLG, SELE, SERPINE1, VIP
16	attenuated familial adenomatous polyposis	35.6	MUTYH, MSH2, MSH6, APC, APEX1, PTGS2
17	peutz-jeghers syndrome	35.1	REEP6, BRCA2, VHL, BMPR1A, MUC3A, MUTYH
18	breast cancer	34.5	BRCA1, BRCA2, MYC, BMP6, UBC, CDK2
19	desmoid tumor	34.2	PCNA, RB1, SERPINE1, CDH2, CDKN1B, CDKN2A
20	turcot syndrome	34.2	BAX, MSH6, MLH1, APC, TP53, PTEN
21	duodenitis	34.0	PIK3CG, KITLG, PCNA, VIP, BRAF, VDR
22	medulloblastoma	32.8	PIK3CG, KLF4, SFRP1, PCNA, BTRC, RB1
23	esophagitis	32.7	PIK3CG, PIN1, KLF4, KLF6, RELA, KITLG
24	endometrial cancer	32.6	PIK3CG, KITLG, PCBD1, PCNA, RB1, SERPINE1
25	lynch syndrome	32.5	BRCA1, BRCA2, MSH2, MSH6, MLH1, EXO1
26	squamous cell carcinoma	32.3	LGALS1, CDH1, MMP7, GSTP1, CCNA2, CCND1
27	thyroid carcinoma	32.3	PIK3CG, KITLG, PCNA, RB1, SELE, SERPINE1
28	papillary thyroid carcinoma	32.2	BRAF, RARB, RAN, RASSF1, BAX, CDH1
29	endometrial carcinoma	32.2	PIK3CG, RELA, SFRP1, PCNA, RB1, SERPINE1
30	ovarian carcinoma	32.1	PIK3CG, RELA, PCNA, BUB1B, RB1, SERPINE1
31	melanoma	32.1	PIK3CG, KLF6, PDCD1, RELA, KITLG, KIF2C
32	hypoxia	32.0	PIK3CG, RELA, KITLG, SFRP1, PCNA, BTRC
33	esophageal squamous cell carcinoma	32.0	PIN1, RELA, PCNA, RB1, SELE, SERPINE1
34	bannayan-riley-ruvalcaba syndrome	31.7	VIM, VHL, BMPR1A, BCL2, LGALS1, CHGA
35	retinoblastoma	31.7	PIK3CG, KLF6, KITLG, PCNA, RB1, VIM
36	hepatoblastoma	31.6	PIK3CG, KITLG, PCNA, BTRC, RB1, SERPINE1
37	thyroid cancer	31.6	PIK3CG, PCNA, BUB1, BUB1B, VIM, NAT2
38	familial colorectal cancer	31.1	BRAF, VDR, BCL2, MUTYH, MSH2, MSH6
39	lung adenocarcinoma	30.9	PIK3CG, KLF6, RB1, BRAF, VEGFA, BMP6
40	allergic rhinitis	29.8	SELE, VIP, VCAM1, IL13, IL4, IL5
41	fibromatosis	29.6	PCNA, RB1, SERPINE1, VIM, MYC, CDH2
42	germ cell tumor	29.6	KITLG, PCNA, BUB1B, RB1, BRAF, BRCA2
43	oral squamous cell carcinoma	29.5	PIN1, PDCD1, SFRP1, PCNA, BUB1B, RB1
44	endocervicitis	29.4	VIM, MYC, BMP2, BCL2, MUC1, MUC5AC
45	carcinoid tumors	29.2	PCNA, VIP, RASSF1, BCL2, CHGA, MUC1
46	renal carcinoma	29.1	PIK3CG, KLF6, PCNA, VIM, VHL, VEGFA
47	gastroduodenitis	28.9	VEGFA, BMP6, CHGA, MUC1, MUC2, MUC3A
48	angiofibroma	28.8	PCNA, VIM, VEGFA, MYC, BMP6, JUP
49	asthma	28.8	SERPINE1, LIFR, MPO, IL13, IL1B, IL4
50	papilloma	28.8	PIN1, PCNA, RB1, VIM, BRAF, BRCA2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to polyposis:

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MGI Mouse Phenotypes related to polyposis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	tumorigenesis	MP:0002006	14.3	KLF4, KITLG, BUB1, BUB1B, BUB3, BTRC
2	digestive/alimentary phenotype	MP:0005381	14.1	KLF4, KITLG, KIF3A, RB1, BRAF, BRCA1
3	renal/urinary system phenotype	MP:0005367	13.9	PDCD1, KIF3A, PCBD1, BRAF, BRCA1, VHL
4	integument phenotype	MP:0010771	13.8	PIK3CG, PIN1, KLF4, KLF6, RELA, KIFAP3
5	behavior/neurological phenotype	MP:0005386	13.1	KLF4, KIFAP3, KIF3A, PCNT, RB1, SELE
6	cardiovascular system phenotype	MP:0005385	12.9	PIK3CG, KLF6, PDCD1, RELA, KIFAP3, KITLG
7	skeleton phenotype	MP:0005390	12.8	PIK3CG, RELA, KITLG, KIF3A, SFRP1, BUB1B
8	reproductive system phenotype	MP:0005389	12.5	KLF4, KLF6, BUB1, BUB1B, BTRC, VIP
9	craniofacial phenotype	MP:0005382	12.1	KLF4, KITLG, KIF3A, BMPR1A, BMPR1B, LEF1
10	no phenotypic analysis	MP:0003012	12.1	SFRP1, PCNA, BUB1, RB1, VEGFA, VCAM1
11	immune system phenotype	MP:0005387	11.8	KIFAP3, SFRP1, BUB1, BUB1B, BTRC, VIM
12	limbs/digits/tail phenotype	MP:0005371	11.7	RELA, KITLG, KIF3A, SFRP1, PCNT, RB1
13	endocrine/exocrine gland phenotype	MP:0005379	11.7	KLF4, BUB1, BRCA1, BRCA2, BMPR1A, BMPR1B
14	vision/eye phenotype	MP:0005391	11.7	PIN1, PDCD1, RELA, KITLG, KIF3A, RDH5
15	respiratory system phenotype	MP:0005388	11.6	KIFAP3, KIF3A, BRCA1, BMPR1A, BMPR2, SCRIB
16	normal phenotype	MP:0002873	11.5	KLF4, REEP5, RELA, BUB1, SELE, VIP
17	muscle phenotype	MP:0005369	11.3	PIK3CG, PDCD1, RELA, KIFAP3, BUB1B, BUB3
18	adipose tissue phenotype	MP:0005375	11.1	SFRP1, BUB1B, BUB3, RB1, SERPINE1, BRAF
19	pigmentation phenotype	MP:0001186	10.9	KITLG, PCBD1, RB1, BRAF, BRCA1, LMNA
20	other phenotype	MP:0005395	10.9	SH2B3, BUB1, RARB, CLU, AXIN1, CDKN2A
21	hearing/vestibular/ear phenotype	MP:0005377	10.6	KITLG, RB1, VDR, LMNA, MYC, BMP2
22	liver/biliary system phenotype	MP:0005370	10.1	KLF6, KIFAP3, BUB1, VHL, VEGFA, MYB
23	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CG, KLF4, RELA, KIFAP3, KITLG, KIF3A
24	hematopoietic system phenotype	MP:0005397	INF	SH2B3, KLF6, PDCD1, KIFAP3, SFRP1, PCNA
25	mortality/aging	MP:0010768	INF	KLF4, KLF6, PDCD1, RELA, KIFAP3, KITLG
26	embryogenesis phenotype	MP:0005380	INF	KLF6, KIFAP3, KIF3A, SFRP1, PCNT, BUB1B
27	nervous system phenotype	MP:0003631	INF	PDCD1, RELA, KITLG, SFRP1, PCNT, RB1
28	cellular phenotype	MP:0005384	INF	PIK3CG, PIN1, SH2B3, KLF4, KLF6, PDCD1
29	growth/size phenotype	MP:0005378	INF	PIK3CG, PIN1, KLF6, RELA, KITLG, KIF3A

Articles related to polyposis:

(show top 50)    (show all 896)

id	Title	Authors	Year	Affiliating Genes
1	The genetics of familial adenomatous polyposis (FAP) and MutYH-associated polyposis (MAP). (22103048)	Claes K.... Kartheuser A.	2011	APC, MUTYH
2	Inactivation of the APC gene is constant in adrenocor tical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers. (20978149)	Gaujoux S.... Bertherat J.	2010	APC
3	Biallelic APC inactivation was responsible for functi onal adrenocortical adenoma in familial adenomatous polyposis with novel germli ne mutation of the APC gene: report of a case. (19684041)	Hosogi H.... Sakai Y.	2009	CTNNB1
4	Localized immunoglobulin E expression in allergic rhinitis and nasal polyposis. (19417663)	Wise S.K.... Schlosser R.J.	2009	IGHE
5	Implication of adenomatous polyposis coli and MUTYH mutations in familial colorectal polyposis. (19279422)	De Rosa M.... Izzo P.	2009	MUTYH
6	Pathological features of colorectal carcinomas in MYH-associated polyposis. (18564191)	O'Shea A.M.... Gallinger S.	2008	MUTYH
7	Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis. (18161889)	Berkhout M.... Peters W.H.	2008	GSTP1, GSTT1, GSTM1
8	Risk of gynecologic cancers in Danish hereditary non-polyposis colorectal cancer families. (18972272)	Boilesen A.E.... Bernstein I.	2008	MSH2, MLH1, MSH6
9	The expression of MMP-2, MMP-7, MMP-9, and TIMP-1 in chronic rhinosinusitis and nasal polyposis. (18656717)	Can I.H.... Karasoy D.S.	2008	MMP2, MMP7, MMP9
10	Germline mutation of adenomatous polyposis coli gene in Chinese patients with familial adenomatous polyposis (18393246)	Wang T.T.... Zhang X.M.	2008	APC
11	An economic assessment of genetic testing for familial adenomatous polyposis (18942899)	Olry de Labry Lima A.... Villegas Portero R.	2008	APC
12	Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome. (18941465)	Vickaryous N.... Silver A.	2008	MYH11
13	Detection of hMSH2 and hMLH1 mutations in Chinese hereditary non-polyposis colorectal cancer kindreds. (18186571)	Zhang C.H.... Zhan W.H.	2008	MLH1
14	Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis. (19013464)	Boparai K.S.... Van Noesel C.J.	2008	APC, KRAS
15	Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC). (17939062)	Geary J.... Hodgson S.V.	2008	MSH2, MLH1
16	Broad phenotypic spectrum in familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at age 72. (19036155)	Nilbert M.... Mangell P.	2008	APC
17	Detection of adenomatous polyposis coli gene mutations in 31 familial adenomatous polyposis families by using denaturing high performance liquid chromatography (18393237)	Cai S.R.... Zheng S.	2008	APC
18	Lack of association between genetic polymorphisms in cytokine genes and disease expression in patients with hereditary non-polyposis colorectal cancer. (17454884)	Talseth B.A.... Scott R.J.	2007	TNF, IL6, IL1B
19	Immunohistochemical expression of MYH protein can be used to identify patients with MYH-associated polyposis. (16890597)	Di Gregorio C.... Ponz de Leon M.	2006	MSH2, MLH1, MSH6
20	Singapore familial adenomatous polyposis (FAP) patients with classical adenomatous polyposis but undetectable APC mutations have accelerated cancer progression. (17026565)	Cao X.... Cheah P.Y.	2006	CTNNB1, AXIN1, MUTYH
21	Loss of extracellular E-cadherin in the normal mucosa of duodenum and colon of patients with familial adenomatous polyposis. (16949915)	Berkhout M.... Nagtegaal I.D.	2006	CDH1, CTNNB1, SMAD4
22	Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion. (14679305)	Faux M.C.... Burgess A.W.	2004	APC
23	Novel germline mutations in the adenomatous polyposis coli gene in Polish families with familial adenomatous polyposis. (14729851)	Plawski A.... Sl/omski R.	2004	APC
24	Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. (15331612)	Li Q.... Dashwood R.H.	2004	APC, CTNNB1, TCF7L2
25	Novel mutations of the APC gene in familial adenomatous polyposis in Greek patients. (12581900)	Mihalatos M.... Nasioulas G.	2003	APC
26	A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis. (12010890)	Phillips R.K.... Steinbach G.	2002	PTGS2
27	Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or 'multiple' colorectal adenomas. (11867715)	Sieber O.M.... Heinimann K.	2002	APC
28	Effect of sulindac treatment for attenuated familial adenomatous polyposis with a new germline APC mutation at codon 161: report of a case. (12394442)	Esaki M.... Iida M.	2002	PTGS2
29	Juvenile polyposis: massive gastric polyposis is more common in MADH4 mutation carriers than in BMPR1A mutation carriers. (12136244)	Friedl W.... Propping P.	2002	BMPR1A, SMAD4
30	Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis. (12417513)	Sayed M.G.... Howe J.R.	2002	BMPR1A, SMAD4
31	Molecular diagnosis of familial adenomatous polyposis (FAP): genotyping of adenomatous polyposis coli (APC) alleles by MALDI-TOF mas s spectrometry. (11983341)	Bonk T.... Becker C.M.	2002	APC
32	The influence of mutation site and age on the severity of duodenal polyposis in patients with familial adenomatous polyposis. (11868006)	Saurin J.C.... Chayvialle J.A.	2002	APC
33	Mutation analysis of the adenomatous polyposis coli (APC) gene in northwest Spanish patients with familial adenomatous polyposis (FAP) and sporadic colorectal cancer. (11668620)	Ruiz-Ponte C.... Barros F.	2001	APC
34	Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register. (11355321)	Kadmon M.... Herfarth C.	2001	APC
35	Beta-catenin and adenomatous polyposis coli (APC) mutations in adenomas from hereditary non-polyposis colorectal cancer patients. (10936679)	Akiyama Y.... Yuasa Y.	2000	CTNNB1
36	Microsatellite instability, a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer. (10323887)	Lamberti C.... Propping P.	1999	MLH1
37	Familial adenomatous polyposis is associated with a marked decrease in alkaline sphingomyelinase activity: a key factor to the unrestrained cell proliferation? (10496347)	Hertervig E.... Duan R.D.	1999	SMPD1, ENPP7
38	Abnormal mucus in cap polyposis. (9518233)	Buisine M.P.... Janin A.	1998	MUC3A
39	Brain tumor-polyposis syndrome: two genetic diseases? (9215849)	Paraf F.... Van Meir E.G.	1997	APC
40	Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53. (9041254)	Bala S.... Ballhausen W.G.	1997	TP53
41	Severe upper gastrointestinal polyposis associated with sparse colonic polyposis in a familial adenomatous polyposis family with an APC mutation at codon 1520. (9391252)	Leggett B.A.... Cowen A.E.	1997	APC
42	Cranial desmoid tumor associated with homozygous inactivation of the adenomatous polyposis coli gene in a 2-year-old girl with familial adenomatous polyposis. (8608492)	de Silva D.C.... Dunlop M.G.	1996	APC
43	Three secretory phospholipase A(2) genes that map to human chromosome 1P35-36 are not mutated in individuals with attenuated adenomatous polyposis coli. (8640784)	Spirio L.N.... White R.	1996	PLA2G2A
44	Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis. (7606737)	Toyooka M.... Miyaki M.	1995	TP53
45	Identification of germ line mutation of APC gene in p ossible carriers of familial adenomatous polyposis (FAP). (7840521)	Baba S.... Nakamura Y.	1994	APC
46	Advanced gastroduodenal polyposis with ras mutations in a patient with familial adenomatous polyposis. (8387955)	Odze R.D.... Gallinger S.	1993	GGT3P
47	Familial adenomatous polyposis. Initial experiences with the Heidelberg polyposis register (1317773)	MAPslein G.... Herfarth C.	1992	APC
48	Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients. (1319835)	Kikuchi-Yanoshita R.... Mori T.	1992	TP53
49	Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors. (1339098)	Nakamura Y.... Horii A.	1992	APC, MCC
50	Mutations of the adenomatous polyposis coli gene in familial polyposis coli patients and sporadic colorectal tumors. (1668888)	Nakamura Y.... Nagase H.	1991	APC, MCC

Genes related to polyposis according to GeneCards:

(show top 50)    (show all 393)

id	Symbol	Description	Score	GeneCards Section Context
1	APC	adenomatous polyposis coli	11.1	Aliases & Descriptions, Publications, Databases, Transcripts (show all 8 sections) Domains & Families, Orthologs, Functions, Summaries
2	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.1	Functions, Publications, Summaries
3	SMAD4	SMAD family member 4	11.1	Publications, Summaries
4	APC2	adenomatosis polyposis coli 2	11.1	Transcripts, Aliases & Descriptions, Publications, Orthologs (show all 6 sections) Domains & Families, Proteins
5	REEP5	receptor accessory protein 5	11.1	Orthologs, Publications, Aliases & Descriptions
6	AXIN2	axin 2	11.1	Summaries, Publications
7	AXIN1	axin 1	11.0	Summaries, Publications
8	MAPRE2	microtubule-associated protein, RP/EB family, member 2	11.0	Summaries, Publications
9	PPARD	peroxisome proliferator-activated receptor delta	11.0	Summaries
10	MAPRE1	microtubule-associated protein, RP/EB family, member 1	11.0	Aliases & Descriptions, Publications
11	MAPRE3	microtubule-associated protein, RP/EB family, member 3	11.0	Summaries, Publications
12	APCDD1	adenomatosis polyposis coli down-regulated 1	11.0	Orthologs, Aliases & Descriptions, Transcripts
13	REEP6	receptor accessory protein 6	11.0	Aliases & Descriptions, Orthologs, Publications
14	APCDD1L	adenomatosis polyposis coli down-regulated 1-like	11.0	Transcripts, Aliases & Descriptions, Orthologs
15	MUC5B	mucin 5B, oligomeric mucus/gel-forming	11.0	Summaries, Publications
16	DLG3	discs, large homolog 3 (Drosophila)	11.0	Summaries
17	FAM123B	family with sequence similarity 123B	11.0	Aliases & Descriptions
18	TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2	11.0	Aliases & Descriptions
19	SPATA13	spermatogenesis associated 13	11.0	Aliases & Descriptions
20	BMPR1A	bone morphogenetic protein receptor, type IA	11.0	Publications
21	MUTYH	mutY homolog (E. coli)	11.0	Publications
22	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Orthologs, Publications
23	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
24	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Orthologs, Publications
25	MSH6	mutS homolog 6 (E. coli)	11.0	Publications
26	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	11.0	Publications
27	STK11	serine/threonine kinase 11	11.0	Publications
28	PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	11.0	Publications
29	CDX2	caudal type homeobox 2	11.0	Publications
30	PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	11.0	Publications
31	PTCH1	patched 1	11.0	Publications
32	PTEN	phosphatase and tensin homolog	11.0	Publications
33	OGG1	8-oxoguanine DNA glycosylase	11.0	Publications
34	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
35	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	11.0	Publications
36	CCND1	cyclin D1	11.0	Publications
37	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0	Publications
38	HNF4A	hepatocyte nuclear factor 4, alpha	11.0	Publications
39	TP53	tumor protein p53	11.0	Publications
40	NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	11.0	Publications
41	KLF4	Kruppel-like factor 4 (gut)	11.0	Publications
42	DVL1	dishevelled, dsh homolog 1 (Drosophila)	11.0	Publications
43	WNT1	wingless-type MMTV integration site family, member 1	11.0	Publications
44	CSNK1E	casein kinase 1, epsilon	11.0	Publications
45	FMO3	flavin containing monooxygenase 3	11.0	Publications
46	XPO1	exportin 1 (CRM1 homolog, yeast)	11.0	Publications
47	CTNND1	catenin (cadherin-associated protein), delta 1	11.0	Publications
48	CTBP1	C-terminal binding protein 1	11.0	Publications
49	DDIT3	DNA-damage-inducible transcript 3	11.0	Publications
50	JUP	junction plakoglobin	11.0	Publications

Pathways related to polyposis according to GeneDecks:

(show top 50)    (show all 242)

id	Pathway	Score	Top Affiliating Genes
1	Wnt signaling pathway20	13.9	SFRP1, BTRC, MYC, RAC1, LEF1, AXIN1
2	WNT Signaling36	13.8	BTRC, VIM, MYC, RAC1, BIRC5, LEF1
3	Pathways in cancer20	13.8	PIK3CG, RELA, RB1, BRCA2, VEGFA, MYC
4	Endometrial cancer20	12.7	PIK3CG, BRAF, MYC, AXIN1, CDH1, MLH1
5	Colorectal cancer20	12.5	PIK3CG, BRAF, RAC1, LEF1, AXIN1, AXIN2
6	Adherens junction20	12.2	RAC1, LEF1, CDC42, CDH1, IQGAP1, IGF1R
7	TGF-beta Signaling Pathways37	11.9	PIK3CG, RELA, BRAF, MYC, RAC1, ATF4
8	MAPK signaling pathway20	11.6	RELA, BRAF, MYC, RAC1, ATF4, JUN
9	p53 Signaling36	11.5	BRCA1, BCL2, CHEK1, UBC, BAX, ATM
10	JNK Pathway36	11.5	KITLG, BMP2, BMP6, RAC1, LIFR, BCL2
11	Cell cycle Regulation of G1/S transition (part 1)10	11.4	BTRC, BRCA1, CDKN1A, CDK2, CDKN1B, CDKN2A
12	Cell cycle_Regulation of G1/S transition (part 1)41	11.4	BTRC, BRCA1, UBC, CDKN1A, CDK2, CDKN1B
13	Non-small cell lung cancer20	11.4	PIK3CG, RB1, BRAF, RASSF5, RASSF1, CDKN2A
14	IL-6 Pathway36	11.2	BRAF, BMP2, BMP6, BAX, IL10, IL11
15	Transcription Androgen Receptor nuclear signaling10	11.2	CDKN1A, MMP2, AR, GSK3B, IL6, CCND1
16	Nanog in Mammalian ESC Pluripotency36	11.1	KITLG, BRAF, BMP2, BMP6, LIFR, AXIN1
17	mTOR Pathway36	11.0	KITLG, BMP2, BMP6, RAC1, FKBP1A, FGF2
18	ERK Signaling36	11.0	KITLG, BRAF, MYC, BMP2, BMP6, LIFR
19	Signal transduction_PTEN pathway41	11.0	PCNA, GSK3B, IGF1R, CASP9
20	Signal transduction PTEN pathway10	10.9	PCNA, LEF1, JUN, CDKN1A, GSK3B, IGF1R
21	Pancreatic cancer20	10.9	BRCA2
22	Cyclins and Cell Cycle Regulation36	10.9	RB1, ATM, CDKN1A, CDK2, CDKN1B, CDKN2A
23	STAT3 Pathway36	10.8	BRAF, MYC, BMP2, BMP6, BMPR1A, BMPR1B
24	Akt Signaling36	10.7	PIK3CG, BMP2, BMPR1A, BMPR1B, BMPR2, LIFR
25	MAPK Signaling36	10.7	KITLG, BRAF, MYC, BMP2, BMP6, RAC1
26	Endothelin-1 Signaling Pathway36	10.7	BRAF, MYC, BMP2, BMP6, LIFR, IL10
27	DHA Signaling36	10.6	KITLG, BMP2, BMP6, BCL2, BAX, GSK3B
28	Estrogen Pathway36	10.6	KITLG, BRAF, BRCA1, BMP2, BMP6, LIFR
29	Telomerase Components in Cell Signaling36	10.4	KITLG, RB1, MYC, BMP2, BMP6, ATM
30	TGF-Beta Pathway36	10.4	KITLG, BMP2, BMP6, BCL2, BAX, JUN
31	Renin-Angiotensin Pathway36	10.3	KITLG, VCAM1, BMP2, BMP6, RAC1, JUN
32	p53 Mediated Apoptosis36	10.3	KITLG, BMP2, BMP6, BCL2, CHEK1, BAX
33	all-trans-Retinoic Acid Signaling in Brain36	10.2	BMP2, BMP6, RARB, BCL2, BAX, IL10
34	Rac1 Pathway36	10.1	KITLG, BMP2, BMP6, RAC1, JUN, CDC42
35	NFAT in Immune Response36	10.1	KITLG, BMP2, BMP6, LIFR, XPO1, JUN
36	14-3-3 Induced Intracellular Signaling36	10.1	KITLG, BMP2, LIFR, JUN, FGF2, IL3
37	Mitochondrial Apoptosis36	9.9	KITLG, BMP2, BMP6, BCL2, BAX, ATM
38	MAPK Family Pathway36	9.9	KITLG, BRAF, BMP2, BMP6, RAC1, BCL2
39	Antioxidant Action of Vitamin-C36	9.9	KITLG, MYH1, BMP2, BMP6, BMPR1A, BMPR1B
40	SOCS Pathway36	9.8	BMP2, BMP6, BCL2, BAX, FGF2, IL10
41	Measles20	9.7	PIK3CG, RELA, CDK2, CDKN1B, CDK4, GSK3B
42	NF-KappaB (p50-p65) Pathway36	9.7	RELA, KITLG, BTRC, BMP2, BMP6, UBC
43	Toxoplasmosis20	9.7	PIK3CG, RELA, BCL2, CD40LG, IL10, MAPK8
44	MIF Mediated Glucocorticoid Regulation36	9.6	BMP2, BMP6, BCL2, BAX, IL10, IL11
45	Asthma20	9.5	CD40LG, IL10, IL13, IL3, IL4, IL5
46	Tec Kinases Signaling36	9.4	KITLG, BMP2, BMP6, BMPR1A, BMPR1B, BMPR2
47	JAK-STAT Pathway36	9.3	KITLG, BRCA1, MYC, BMP2, BMP6, RAN
48	Influenza A20	8.7	PIK3CG, RELA, XPO1, JUN, GSK3B, IL1A
49	Leishmaniasis20	8.5	RELA, JUN, IL10, IL1A, IL1B, IL4
50	Rheumatoid arthritis20	6.8	VEGFA, JUN, MMP1, IL11, IL17A, IL1A

Compounds related to polyposis according to GeneDecks:

(show top 50)    (show all 453)

id	Compound	Score	Top Affiliating Genes
1	estrogen32	15.1	KLF6, PCBD1, PCNA, SERPINE1, VIP, NAT1
2	progesterone32 42 9 18 9	18.2	PCNA, RB1, BRAF, BRCA1, BRCA2, MYB
3	lipid32	12.9	PIK3CG, KITLG, RB1, SELE, SERPINE1, VIM
4	5-aza-2deoxycytidine32	12.7	KITLG, SFRP1, PCNA, VIM, BRCA1, VHL
5	fatty acid32	12.6	BRAF, BRCA1, MYB, USF2, USF1, CLU
6	gtp32	12.4	KIFAP3, PCBD1, VIP, BRAF, RAN, RAC1
7	retinoic acid32 42 18	14.4	PIK3CG, KITLG, RB1, SERPINE1, BRAF, BRCA1
8	2-methoxyestradiol32 18	13.0	PCNA, BCL2, UGT1A1, UGT1A10, UGT1A3, UGT1A4
9	butyrate32	11.8	KLF4, KITLG, PCNA, RB1, VIM, VDR
10	threonine32	11.8	BMP2, BMPR1A, BMPR1B, BMPR2, KHDRBS1, MUC2
11	okadaic acid32 42	12.8	RELA, RB1, VIM, MYC, MYB, BMP6
12	quercetin32 42 9 18 9	15.6	PIK3CG, SELE, VCAM1, BIRC5, BCL2, UGT1A1
13	adriamycin32	11.5	RB1, VIM, BRCA1, BRCA2, VDR, MYC
14	dmso32	11.5	KITLG, VIM, BMP6, CHGA, UGT1A6, MUC5AC
15	gemcitabine32 34 9 9	14.5	PCNA, BRCA1, VEGFA, MYC, BIRC5, BCL2
16	egcg32	11.4	PIK3CG, UGT1A1, CDK2, IL1A, MAPK8, MAP3K1
17	biotin32 9 18 9	14.4	KLF4, KITLG, PCNA, RB1, VIM, MUC1
18	bromodeoxyuridine32	11.3	KITLG, PCNA, RB1, VIM, MYC, MYB
19	thymidylate32	11.3	PCNA, RB1, VIM, BRCA1, VEGFA, VDR
20	phosphatidylserine32 9 9	13.3	SELE, VIM, RAC1, BCL2, LGALS1, CD79A
21	ionomycin32	11.2	CLIP1, CD274, CDK4, IL3, IL5, IL9
22	mifepristone32 42 9 9	14.0	BIRC5, MUC1, BAX, JUN, CDK2, MMP1
23	l-nmma32	10.9	VIP, VCAM1, XDH, IL1RN, IGHE, CAT
24	staurosporin32	10.9	PIK3CG, BCL2, JUN, CDKN3, IL8, CASP3
25	gf 109203x32 42	11.9	PIK3CG, KITLG, VEGFA, CFTR, JUN, CDKN1A
26	curcumin32	10.9	PIK3CG, NAT1, VEGFA, VCAM1, MYC, BIRC5
27	prostacyclin32	10.8	SELE, SERPINE1, VIP, VEGFA, VCAM1, BMP6
28	indomethacin32 9 9	12.8	PCNA, VIM, VIP, MYC, BMP2, BMP6
29	bleomycin32 9 9	12.8	BRCA1, BRCA2, ATM, CDKN3, GSTM1, GSTP1
30	cyclophosphamide32 34 9 9	13.8	MBL2, TRB@
31	imatinib32 34 9 9	13.7	PIK3CG, KITLG, VIP, BRAF, VEGFA, MYC
32	azathioprine32 34 9 9	13.7	PCNA, VIM, BMP2, RARB, RASSF1, RAC1
33	prostaglandin32	10.7	KITLG, VIM, VIP, MUC5AC, CDK4, MMP1
34	ivig32	10.7	IL3, TG, CSF1, CSF2
35	caffeine32 34 9 18 9	14.5	PCNA, VIP, NAT1, NAT2, BRCA1, VDR
36	suramin32 9 9	12.5	PCNA, VIP, VEGFA, BMP6, CFTR, CD79A
37	go 697632 42	11.5	PIK3CG, CHEK1, CDH1, MMP2, IL8, MAPK8
38	iron32 18	11.5	KITLG, VIM, VHL, MYB, USF2, XDH
39	wortmannin32 42	11.4	PIK3CG, KITLG, VIM, BRAF, VCAM1, BMP2
40	tgf beta132	10.4	KITLG, SERPINE1, VCAM1, BMP6, CDKN1A, CDK2
41	carboplatin32 34 9 9	13.4	KITLG, RB1, BRCA1, VEGFA, BCL2, CHGA
42	tetracycline32 9 9	12.3	RB1, BMP2, RAC1, CDK2, CDKN2A, CD40LG
43	genistein32 9 18 9	13.3	PIK3CG, KITLG, PCNA, RB1, SELE, SERPINE1
44	ribonucleic acid32	10.1	KLF6, KITLG, MYC, BMP2, BMP6, RARB
45	15-deoxy-delta-12,14-prostaglandin j232	9.9	PIK3CG, SERPINE1, VEGFA, VCAM1, MYC, BMP6
46	thalidomide32 42 9 9	12.8	VEGFA, BIRC5, CD40LG, FGF2, IL10, IL11
47	pdtc32	9.3	PIK3CG, SELE, VCAM1, BIRC5, BCL2, XDH
48	polyinosinic-polycytidylic acid32	8.5	SELE, VCAM1, IRF1, IL10, IL2, IL4
49	il 1032	8.0	VDR, BMP6, IL10, IL13, IL1A, IL1B
50	trastuzumab32 34 9 9	INF	PIK3CG, BIRC5, MUC1, CDK2, CDKN1B, CDKN3

Cellular components related to polyposis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	16.0	GUK1, AMD1, CASP7, CASP3, CAT, CA1
2	nucleus	GO:005634	15.6	VDR, LMNA, MYC, RARB, RASSF1, USF2
3	cytoplasm	GO:005737	14.3	XPO1, GSTP1, FGF2, MEN1, IL11, IL13
4	nucleoplasm	GO:005654	12.1	CDKN1A, ESR2, TP53, DDIT3, PPARG, PPARA
5	transcription factor complex	GO:005667	11.1	CTBP1, CDK4, CDK2, JUN, ATF4, LEF1
6	protein complex	GO:043234	10.3	ALB, HNF1A, TP53, PTGS2, TOP2A, SYP
7	external side of plasma membrane	GO:009897	9.0	IL1RL1, IL17A, IL13, ITGAE, CD274, CD40LG
8	extracellular region	GO:005576	8.9	ESR2, IL6, HSPG2, HLA-C, TUBA4A, TMEFF2
9	extracellular space	GO:005615	8.2	CSF1, CSF2, WNT5A, HGF, SOD1, MMP9
10	plasma membrane	GO:005886	INF	DLG3, DLG4, SRC, CTNNA1, CTNNB1, CTNND1

Biological processes related to polyposis according to GeneDecks:

(show top 50)    (show all 76)

id	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:006915	12.8	PDCD1, PCNT, BUB1, BUB1B, VIM, BRCA1
2	Wnt receptor signaling pathway	GO:016055	12.5	BTRC, LEF1, CDC73, APC2, APCDD1, MCC
3	canonical Wnt receptor signaling pathway	GO:060070	12.4	SFRP1, MYC, LEF1, AXIN1, CDC42, GSK3B
4	positive regulation of transcription, DNA-dependent	GO:045893	12.3	KLF4, KLF6, RELA, SFRP1, BTRC, RB1
5	cell proliferation	GO:008283	12.3	KITLG, KIF2C, PCNA, BUB1, BUB1B, KHDRBS1
6	protein phosphorylation	GO:006468	12.2	BRAF, BMPR1A, BMPR1B, BIRC5, CDK4, IRF1
7	negative regulation of transcription from RNA polymerase II promoter	GO:000122	12.2	KLF4, VHL, VDR, MYC, MYB, BMP2
8	negative regulation of canonical Wnt receptor signaling pathway	GO:090090	12.1	SFRP1, LEF1, AXIN2, CDH2, GSK3B, APC
9	transcription initiation from RNA polymerase II promoter	GO:006367	12.0	SERPINE1, VDR, MYC, RARB, UBC, AR
10	response to DNA damage stimulus	GO:006974	11.9	BRCA1, MYC, RASSF1, BCL2, CHEK1, BAX
11	mitotic cell cycle	GO:000278	11.7	KIF2C, PCNA, PCNT, BUB1, BUB1B, BUB3
12	transforming growth factor beta receptor signaling pathway	GO:007179	11.7	SERPINE1, MYC, BMPR1A, USP15, UBC, XPO1
13	DNA repair	GO:006281	11.6	PCNA, BRCA1, BRCA2, CHEK1, MUTYH, UBC
14	induction of apoptosis by intracellular signals	GO:008629	11.5	MYC, CLU, BCL2, BAX, MSH6, CDKN1A
15	positive regulation of apoptotic process	GO:043065	11.5	SFRP1, BMP2, RARB, CLU, SCRIB, BAX
16	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	11.5	PIN1, USP15, UBC, XPO1, ENG, TP53
17	cell cycle arrest	GO:007050	11.5	RB1, MYC, RASSF1, KHDRBS1, MSH2, ATM
18	negative regulation of cell growth	GO:030308	11.4	SFRP1, RB1, BMPR2, BCL2, CDKN1A, CDKN1B
19	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	11.4	BMP2, BMP6, BMPR1A, BMPR2, INHBA, ENG
20	negative regulation of cell proliferation	GO:008285	11.4	KLF4, KIFAP3, SFRP1, VHL, VDR, BMP2
21	negative regulation of transcription, DNA-dependent	GO:045892	11.3	KLF4, RELA, SFRP1, BTRC, RB1, BRCA1
22	epidermal growth factor receptor signaling pathway	GO:007173	11.2	UBC, CDKN1B, CDC42, GSK3B, CASP9, HRAS
23	positive regulation of bone mineralization	GO:030501	11.2	BMP2, BMP6, BMPR1A, BMPR1B, BMPR2, FBN2
24	signal transduction	GO:007165	11.2	PDCD1, KIFAP3, KITLG, BTRC, VDR, RARB
25	response to drug	GO:042493	11.1	SFRP1, MYC, BCL2, LGALS1, CHRNA3, UGT1A1
26	positive regulation of cell migration	GO:030335	11.0	VEGFA, BMP2, LEF1, CDH13, MMP14, ILK
27	response to organic cyclic compound	GO:014070	11.0	SFRP1, LEF1, UGT1A1, MSH2, JUN, CDKN1A
28	positive regulation of protein phosphorylation	GO:001934	11.0	PIN1, VEGFA, BMP2, AXIN1, AXIN2, IL1B
29	blood coagulation	GO:007596	11.0	PIK3CG, SH2B3, KIFAP3, KIF3A, KIF2C, SERPINE1
30	response to gamma radiation	GO:010332	10.8	BRCA2, MYC, BCL2, BAX, MEN1, IL1A
31	positive regulation of osteoblast differentiation	GO:045669	10.6	BMP2, BMP6, BMPR1A, BMPR1B, BMPR2, FGF2
32	induction of apoptosis	GO:006917	10.6	BAX, CDKN1B, CDKN2A, IRF1, INHBA, CASP3
33	cellular response to organic cyclic compound	GO:071407	10.5	BTRC, BMP2, LGALS1, CDKN1B, MGMT, IL1B
34	positive regulation of endothelial cell proliferation	GO:001938	10.5	VEGFA, BMP2, BMP6, BMPR2, JUN, CDH13
35	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.5	KLF4, KLF6, RELA, RB1, SERPINE1, BRCA1
36	aging	GO:007568	10.5	VDR, VCAM1, JUN, IL1B, CCL2, CCL5
37	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	10.5	JUP, IL10, IL1B, IL4, IL5, IL6
38	anti-apoptosis	GO:006916	10.4	RELA, BRAF, VHL, BIRC5, BCL2, MUC1
39	positive regulation of fibroblast proliferation	GO:048146	10.4	MYC, JUN, CDKN1A, CDK4, IGF1, PDGFB
40	negative regulation of apoptotic process	GO:043066	10.3	PIK3CG, RELA, SFRP1, SERPINE1, BRAF, VEGFA
41	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.2	MYC, BAX, XDH, CDKN1B, CDKN2A, IFI27
42	cellular response to interleukin-1	GO:071347	10.0	RELA, SFRP1, MMP9, IRF1, IL17A, IL8
43	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.0	RELA, CLU, UBC, AR, IL1B, IL6
44	inflammatory response	GO:006954	9.9	PIK3CG, RELA, SELE, BMP2, BMP6, BMPR1B
45	response to hypoxia	GO:001666	9.8	VEGFA, VCAM1, BMP2, USF1, BCL2, ATM
46	platelet activation	GO:030168	9.7	PIK3CG, SERPINE1, VEGFA, RAC1, CLU, CD40LG
47	immune response	GO:006955	9.5	BMP6, BMPR1A, CD274, IL13, IL17A, IL1A
48	cytokine-mediated signaling pathway	GO:019221	9.4	PIN1, KLF6, RELA, VCAM1, LIFR, UBC
49	positive regulation of nitric oxide biosynthetic process	GO:045429	9.2	IL1B, IFNG, ICAM1, ESR1, TNF, PTGS2
50	positive regulation of cell proliferation	GO:008284	INF	SFRP1, VIP, VEGFA, MYC, LIFR, BIRC5

Molecular functions related to polyposis according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:019899	13.0	PPARG, NR5A1, NOD2, RXRA, EGFR, H2AFX
2	protein kinase binding	GO:019901	12.5	SMAD3, USF1, MAP3K1, APC, ILK, GSK3B
3	beta-catenin binding	GO:008013	12.2	CSNK2A1, CTNNBIP1, TCF7L2, SMAD3, BTRC, LEF1
4	protein homodimerization activity	GO:042803	12.0	BMPR1A, USF2, USF1, BIRC5, CLIP1, BCL2
5	sequence-specific DNA binding transcription factor activity	GO:003700	12.0	ESR2, PPARA, TP53, TBX21, DDIT3, CTBP1
6	protein heterodimerization activity	GO:046982	11.8	HGF, HNF1A, TCF4, UGT1A6, BAX, INHBA
7	transcription factor binding	GO:008134	11.6	CDKN2A, AR, TP53, TNFRSF10A, DDIT3, CTBP1
8	transcription regulatory region DNA binding	GO:044212	11.4	AR, LEF1, BRCA1, RELA, KLF4, JUN
9	double-stranded DNA binding	GO:003690	11.2	NFKB1, EGFR, STAT1, RXRA, SMAD3, SMAD2
10	identical protein binding	GO:042802	11.1	IGF1R, GLUL, ESR1, TP53, CSNK2B, STK4
11	steroid hormone receptor activity	GO:003707	11.0	PPARD, HNF4A, NR5A1, VDR, RARB, RXRA
12	chromatin binding	GO:003682	10.8	TGIF1, TFAP2A, TOP2A, PRKCB, RELA, GATA2
13	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	GO:004879	10.8	AR, HNF4A, ESR2, PTGER3, PPARD, NR1H2
14	growth factor activity	GO:008083	9.4	IL5, CSF2, VEGFA, BMP2, BMP6, INHBA
15	cytokine activity	GO:005125	9.1	IL2, IL1B, IL1A, IL17A, IL13, IL11
16	protein binding	GO:005515	INF	RXRA, ACVRL1, ELAVL1, H2AFX, HIF1A, TOP2A