MCID: PLY073
MIFTS: 32

Polyposis, Gastric malady

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Polyposis, Gastric

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Sources:
50OMIM, 52Orphanet, 48Novoseek, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Polyposis, Gastric:

Name: Polyposis, Gastric 50 48
Hyperplastic Polyposis Syndrome 52
 
Serrated Polyposis 52

Characteristics:

Orphanet epidemiological data:

52
hyperplastic polyposis syndrome:
Inheritance: Autosomal dominant,Multigenic/multifactorial

Classifications:



External Ids:

OMIM50 175020
Orphanet52 ORPHA157798
ICD10 via Orphanet29 D12.6

Summaries for Polyposis, Gastric

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MalaCards based summary: Polyposis, Gastric, also known as hyperplastic polyposis syndrome, is related to colorectal cancer and thyroid malformation, and has symptoms including multiple gastric polyps An important gene associated with Polyposis, Gastric is RNF43 (Ring Finger Protein 43), and among its related pathways are Selenium Pathway and Rheumatoid arthritis. Affiliated tissues include colon, and related mouse phenotype neoplasm.

Description from OMIM:50 175020

Related Diseases for Polyposis, Gastric

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Diseases related to Polyposis, Gastric via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer10.3
2thyroid malformation10.2IL1B, TNF
3baetz-greenwalt syndrome10.2IL1B, TNF
4pulmonary hypertension10.2IL1B, TNF
5scrotum paget's disease10.2IL1B, TNF
6warm antibody hemolytic anemia10.2IL1B, TNF
7cartilage disease10.2IL1B, TNF
8hypothyroidism10.2IL1B, TNF
9autoimmune polyendocrine syndrome10.2IL1B, TNF
10ileocolitis10.2IL1B, TNF
11rectosigmoid junction neoplasm10.2IL1B, TNF
12skin disease10.2IL1B, TNF
13scarlet fever10.2IL1B, TNF
14non-secretory myeloma10.2IL1B, TNF
15spastic paraplegia-paget disease of bone syndrome10.2IL1B, TNF
16amyotrophic lateral sclerosis type 410.2IL1B, TNF
17paraphimosis10.2IL1B, TNF
18qualitative platelet defect10.2IL1B, TNF
19sterility due to immotile flagella10.2IL1B, TNF
20burns10.2IL1B, TNF
21orbital lymphangioma10.2IL1B, TNF
22pseudoretinitis pigmentosa10.2IL1B, TNF
23paraneoplastic polyneuropathy10.2IL1B, TNF
24scn8a encephalopathy10.2IL1B, TNF
25thoracic aortic aneurysm10.2IL1B, TNF
26ampulla of vater neoplasm10.2IL1B, TNF
27oral candidiasis10.2IL1B, TNF
28meier-gorlin syndrome 310.2IL1B, TNF
29foodborne botulism10.2IL1B, TNF
30inner ear cancer10.2IL1B, TNF
31keloids10.2IL1B, TNF
32accessory nerve disease10.2IL1B, TNF
33senile cataract10.2IL1B, TNF
34osmotic diarrhea10.2IL1B, TNF
35oesophagostomiasis10.2IL1B, TNF
36pyloric stenosis, infantile hypertrophic, 210.2IL1B, TNF
37tibialis tendinitis10.2IL1B, TNF
38bartonellosis10.2IL1B, TNF
39gastric dilatation10.2IL1B, TNF
40kidney angiomyolipoma10.2IL1B, TNF
41nephrosclerosis10.2IL1B, TNF
42ehlers-danlos syndrome, musculocontractural type10.2IL1B, TNF
43benign lymphoepithelial lesion of salivary gland10.2IL1B, TNF
44cervix erosion10.2IL1B, TNF
45isolated congenital auditory ossicle malformation10.2IL1B, TNF
46nasopharyngitis10.2IL1B, TNF
47serous labyrinthitis10.2IL1B, TNF
48corneal intraepithelial neoplasm10.2IL1B, TNF
49pediatric supratentorial ependymoma10.2IL1B, TNF
50retroperitoneal fibrosis10.2IL1B, TNF

Graphical network of the top 20 diseases related to Polyposis, Gastric:



Diseases related to polyposis, gastric

Symptoms for Polyposis, Gastric

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Symptoms by clinical synopsis from OMIM:

175020

Clinical features from OMIM:

175020

HPO human phenotypes related to Polyposis, Gastric:

id Description Frequency HPO Source Accession
1 multiple gastric polyps HP:0004394

Drugs & Therapeutics for Polyposis, Gastric

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Drugs for Polyposis, Gastric (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DexlansoprazolePhase 4204138530-94-6, 103577-45-39578005
Synonyms:
138530-94-6
CHEMBL1201863
CID9578005
D08903
Dexlansoprazole (INN/USAN)
KS-1075
 
Kapidex
MolPort-002-885-834
T 168390
TAK 390
UNII-UYE4T5I70X
ZINC00599734
dexlansoprazole
2
Proton pump inhibitorsPhase 41057
Synonyms:
 
PPIs
3
LansoprazolePhase 4204103577-45-33883
Synonyms:
103577-45-3
2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole
2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole
2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)-1H-benzimidazole
2-({[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole
2-[({3-methyl-4-[(2,2,2-trifluoroethyl)oxy]pyridin-2-yl}methyl)sulfinyl]-1H-benzimidazole
2-[[3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl] methyl] sulfinyl] benzimidazole
2-[[[3-methyl-4-(2,2,2-trifluroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole
A 65006
A-65006
AB00052388
ABT-006
AC1L1GX8
AG 1749
AG-1749
Abbot Brand of Lansoprazole
Agopton
Almirall Brand of Lansoprazole
Amarin
Aprazol
BIDD:GT0006
BPBio1_001194
BRD-A49172652-001-05-7
BRN 4333393
BSPBio_001084
BSPBio_001830
Bamalite
Bio-0824
Biuret
Biuret Gr
Biuret Reagent
Biuret Reagent Solution
Blason
C058687
C16H14F3N3O2S
CAS-103577-45-3
CG-4801
CHEBI:6375
CHEMBL480
CID3883
CPD000058469
Compraz
D00355
DB00448
Dakar
DivK1c_000920
EU-0100709
FT-0082011
HMS1571G06
HMS1922M04
HMS2052F05
HMS2093M07
HMS502N22
HSDB 7204
Hoechst Brand of Lansoprazole
Hormona Brand of Lansoprazole
I06-0018
IDI1_000920
Ilsatec
KBio1_000920
KBio2_002060
KBio2_004628
KBio2_007196
KBio3_001330
KBioGR_001491
KBioSS_002060
Ketian
L 8533
L8533_SIGMA
LS-33080
Lancid
Lanfast
Lanproton
Lansopep
Lansophed
Lansoprazol
Lansoprazol [INN-Spanish]
Lansoprazole
Lansoprazole (JAN/USP/INN)
Lansoprazole [USAN:BAN:INN]
Lansoprazole [Usan:Ban:Inn]
Lansoprazolum
Lansoprazolum [INN-Latin]
Lansox
Lanston
 
Lanz
Lanzo
Lanzol
Lanzol-30
Lanzopral
Lanzor
Lanzul
Lapraz
Lasoprol
Lederle Brand of Lansoprazole
Limpidex
Linamarin
Lopac-L-8533
Lopac0_000709
MLS-0003247.0001
MLS000069705
MLS000759405
MLS001074170
Mesactol
MolPort-003-666-508
MolPort-006-394-760
Monolitum
NCGC00015615-01
NCGC00015615-02
NCGC00015615-03
NCGC00015615-06
NCGC00015615-11
NCGC00023826-03
NCGC00023826-04
NCGC00023826-05
NCGC00023826-06
NCGC00023826-07
NINDS_000920
Ogast
Ogastro
Opiren
Prestwick0_001072
Prestwick1_001072
Prestwick2_001072
Prestwick3_001072
PrevOnco
Prevacid
Prevacid (TN)
Prevacid I.V
Prevacid I.V.
Prevacid Iv
Prevacid SoluTab
Prevacid Solutab
Prevacid, Prevacid NapraPAC, Prevacid SoluTab, Lansoprazole
Prevpac
Prezal
Pro Ulco
Promeco
Promeco Brand of Lansoprazole
Promp
Prosogan
S1354_Selleck
SAM001246544
SMR000058469
SPBio_000488
SPBio_002992
SPECTRUM1503926
STK621169
Salvar Brand of Lansoprazole
Spectrum2_000444
Spectrum3_000295
Spectrum4_000856
Spectrum5_001521
Spectrum_001580
Suprecid
TAK 390MR
TAK-390MR
TAK390MR
TAP Brand of Lansoprazole
TL8000155
Takeda Brand of Lansoprazole
Takepron
Tecnobio Brand of Lansoprazole
UNII-0K5C5T2QPG
Ulpax
Vinas Brand of Lansoprazole
Wyeth Brand of Lansoprazole
Zoprol
Zoton
lansoprazole
lansoprazole sulphone
lanzoprazole
4
AspirinPhase 3107450-78-22244
Synonyms:
11126-35-5
11126-37-7
1oxr
2-(ACETYLOXY)benzoic acid
2-(Acetyloxy)benzoate
2-(Acetyloxy)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoate
2-Acetoxybenzoic acid
2-Carboxyphenyl acetate
2349-94-2
26914-13-6
50-78-2
8-hour Bayer
98201-60-6
A 5376
A.S.A
A.S.A.
A.S.A. Empirin
A.S.A. empirin
A2093_SIGMA
A3160_SIGMA
A5376_SIGMA
A6810_SIGMA
AB1003266
AC 5230
AC1L1D8U
AC1Q1LA0
ACETYLSALICYLIC ACID
AI3-02956
AIN
AKOS000118884
ASA
Acenterine
Acesal
Acetal
Acetard
Aceticyl
Acetilsalicilico
Acetilum acidulatum
Acetisal
Acetol
Acetonyl
Acetophen
Acetosal
Acetosalic acid
Acetosalin
Acetoxybenzoic acid
Acetylin
Acetylsal
Acetylsalicylate
Acetylsalicylic acid
Acetylsalicylsaeure
Acetylsalicylsaure
Acetylsalycilic acid
Acetyonyl
Acetysal
Acetysalicylic acid
Acide 2-(acetyloxy)benzoique
Acide acetylsalicylique
Acide acétylsalicylique
Acido O-acetil-benzoico
Acido acetilsalicilico
Acidum acetylsalicylicum
Acimetten
Acisal
Acylpyrin
Adiro
Aloxiprimum
Asacard
Asagran
Asatard
Ascoden-30
Aspalon
Aspec
Aspergum
Aspir-Mox
Aspirdrops
Aspirin
Aspirin (JP15/USP)
Aspirin [BAN:JAN]
Aspirina 03
Aspirine
Asprin
Aspro
Aspro Clear
Asteric
Azetylsalizylsaeure
Azetylsalizylsäure
BIDD:GT0118
BRN 0779271
Bay-e-4465
Bayer
Bayer Aspirin 8 Hour
Bayer Buffered
Bayer Extra Strength Aspirin For Migraine Pain
Bayer Plus
Benaspir
Bi-prin
Bialpirina
Bialpirinia
Bufferin
C01405
CCRIS 3243
CHEBI:15365
CHEMBL25
CID2244
Caprin
Cardioaspirin
Cardioaspirina
Cemirit
Claradin
Clariprin
Colfarit
Contrheuma retard
Coricidin
Crystar
D00109
D001241
DB00945
Decaten
Delgesic
Dispril
DivK1c_000555
Dolean pH 8
Duramax
ECM
EINECS 200-064-1
EU-0100038
Easprin
Easprin (TN)
Ecolen
Ecotrin
Empirin
Empirin with Codeine
Endosprin
Endydol
 
Entericin
Enterophen
Enterosarein
Enterosarine
Entrophen
Extren
Globentyl
Globoid
HMS1920E13
HMS2090G03
HMS2091K13
HMS501L17
HSDB 652
Helicon
I14-7505
IDI1_000555
Idragin
Istopirin
KBio1_000555
KBio2_001725
KBio2_002271
KBio2_004293
KBio2_004839
KBio2_006861
KBio2_007407
KBio3_002149
KBio3_002751
KBioGR_000398
KBioGR_002271
KBioSS_001725
KBioSS_002272
Kapsazal
Kyselina 2-acetoxybenzoova
Kyselina acetylsalicylova
LS-143
Levius
Lopac-A-5376
Lopac0_000038
MLS001055329
MLS001066332
MLS001336045
MLS001336046
Magnecyl
Measurin
Medisyl
Micristin
MolPort-000-871-622
NCGC00015067-01
NCGC00015067-04
NCGC00015067-09
NCGC00090977-01
NCGC00090977-02
NCGC00090977-03
NCGC00090977-04
NCGC00090977-05
NCGC00090977-06
NCGC00090977-07
NCI60_002222
NINDS_000555
NSC 27223
NSC27223
NSC406186
Neuronika
Novid
Nu-seals
Nu-seals aspirin
O-(Acetyloxy)benzoate
O-(Acetyloxy)benzoic acid
O-Acetoxybenzoate
O-Acetoxybenzoic acid
O-Acetylsalicylic acid
O-Carboxyphenyl acetate
O-accetylsalicylic acid
O-acetylsalicylic acid
PL-2200
Persistin
Pharmacin
Pirseal
Polopirin
Polopiryna
Premaspin
R16CO5Y76E [UNII]
Rheumin tabletten
Rheumintabletten
Rhodine
Rhonal
Ronal
S-211
SMR000059138
SP 189
SPBio_001838
SPECTRUM1500130
ST075414
Salacetin
Salcetogen
Saletin
Salicylic acid acetate
Salicylic acid, acetate
Salospir
Solfrin
Solprin
Solprin acid
Solpyron
Solupsan
Spectrum2_001899
Spectrum3_001295
Spectrum4_000099
Spectrum5_000740
Spectrum_001245
Spira-Dine
St. Joseph
St. Joseph Aspirin for Adults
Supac
Tasprin
Temperal
Toldex
Triaminicin
Triple-sal
UNII R16CO5Y76E
UNII-R16CO5Y76E
UNII=R16CO5Y76E
UNM-0000306102
Vanquish
WLN: QVR BOV1
XAXA
Xaxa
Yasta
ZORprin
aspirin
cMAP_000006
component of Midol
component of Synirin
nchem.859-comp6
o-Acetoxybenzoic acid
o-Carboxyphenyl acetate
o-acetoxybenzoic acid
o-carboxyphenyl acetate
ácido acetilsalicílico
5
Curcumin131458-37-7969516
Synonyms:
1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione
C.I. Natural Yellow 3
CI Natural Yellow 3
Cucurmin
Curcuma
Curcumin
Curcumin I
Diferaloylmethane
Diferuloylmethane
Gelbwurz
Golden seal
Haidr
Halad
Haldar
Halud
Hydrastis
 
Indian saffron
Indian turmeric
Kacha haldi
Kurkumin [czech]
Merita earth
Natural yellow 3
Orange root
Safran D'inde
Souchet
Terra merita
Tumeric yellow
Turmeric
Turmeric (>98% curcurmin)
Turmeric oleoresin (79%-85% curcumin)
Turmeric yellow
Yellow ginger
Yellow puccoon
Yellow root
Yo-kin
Zlut prirodni 3 [Czech]
6COLANutraceutical1824

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Vonoprazan Study in Patients With Erosive Esophagitis to Evaluate Long-term SafetyRecruitingNCT02679508Phase 4
2Magnetic-controlled Capsule Endoscopy vs. Gastroscopy for Detection of Gastric DiseasesCompletedNCT02219529Phase 3
3Aspirin for Uncontrolled AsthmaNot yet recruitingNCT02906761Phase 3
4Remote-controlled Capsule Endoscopy: a Feasibility StudyRecruitingNCT01946633
5Cancer Research Repository for Individuals With Cancer Diagnosis and High Risk Individuals.RecruitingNCT02012699
6Hereditary Colorectal and Associated Tumor Registry StudyRecruitingNCT00633607
7French Digestive Polyposis Cohorte Family Adenomatous Polyposis With APC and MYH Gene Mutations , Cowden's Disease With PTEN Gene Mutation, Peutz Jeghers Disease With STK 11 Gene Mutation ,juvénil Polyposis With SMAD 4 Gene Mutation , Serrated and HyperplRecruitingNCT01987518
8Use of Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP)RecruitingNCT00927485
9Chemoprevention of Gastric Cancer by Intervention With Helicobacter Pylori and Cyclooxygenase PathwayActive, not recruitingNCT00498134
10SB3 Battery Life Observational StudyEnrolling by invitationNCT02382705
11Fundic Gland Polyps and Proton Pump Inhibitor (PPI) DrugsTerminatedNCT01130363

Search NIH Clinical Center for Polyposis, Gastric

Genetic Tests for Polyposis, Gastric

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Anatomical Context for Polyposis, Gastric

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MalaCards organs/tissues related to Polyposis, Gastric:

34
Colon

Animal Models for Polyposis, Gastric or affiliated genes

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MGI Mouse Phenotypes related to Polyposis, Gastric:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0APC, IL1B, RNF43, TNF

Publications for Polyposis, Gastric

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Variations for Polyposis, Gastric

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Copy number variations for Polyposis, Gastric from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1121765184681058046865409Pathogenic mutation c.1264_1265delinsaSMAD4Serrated polyposis

Expression for genes affiliated with Polyposis, Gastric

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Search GEO for disease gene expression data for Polyposis, Gastric.

Pathways for genes affiliated with Polyposis, Gastric

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GO Terms for genes affiliated with Polyposis, Gastric

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Biological processes related to Polyposis, Gastric according to GeneCards Suite gene sharing:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:00605599.6IL1B, TNF
2positive regulation of membrane protein ectodomain proteolysisGO:00510449.6IL1B, TNF
3sequestering of triglycerideGO:00307309.6IL1B, TNF
4chronic inflammatory response to antigenic stimulusGO:00024399.6IL1B, TNF
5regulation of establishment of endothelial barrierGO:19031409.6IL1B, TNF
6positive regulation of chemokine biosynthetic processGO:00450809.6IL1B, TNF
7positive regulation of NF-kappaB import into nucleusGO:00423469.6IL1B, TNF
8lipopolysaccharide-mediated signaling pathwayGO:00316639.5IL1B, TNF
9positive regulation of interferon-gamma productionGO:00327299.5IL1B, TNF
10protein kinase B signalingGO:00434919.5IL1B, TNF
11positive regulation of heterotypic cell-cell adhesionGO:00341169.5IL1B, TNF
12positive regulation of fever generationGO:00316229.5IL1B, TNF
13negative regulation of lipid catabolic processGO:00509959.5IL1B, TNF
14regulation of insulin secretionGO:00507969.5IL1B, TNF
15negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5IL1B, TNF
16regulation of I-kappaB kinase/NF-kappaB signalingGO:00431229.4IL1B, TNF
17positive regulation of JNK cascadeGO:00463309.4IL1B, TNF
18positive regulation of JUN kinase activityGO:00435079.4IL1B, TNF
19cellular response to organic cyclic compoundGO:00714079.4IL1B, TNF
20positive regulation of interleukin-8 productionGO:00327579.3IL1B, TNF
21positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.3IL1B, TNF
22positive regulation of interleukin-6 productionGO:00327559.3IL1B, TNF
23positive regulation of nitric oxide biosynthetic processGO:00454299.1IL1B, TNF
24positive regulation of phagocytosisGO:00507669.0IL1B, TNF
25activation of MAPK activityGO:00001879.0IL1B, TNF
26leukocyte migrationGO:00509008.7IL1B, TNF
27positive regulation of apoptotic processGO:00430658.4APC, IL1B, TNF

Sources for Polyposis, Gastric

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet