MCID: PLY020
MIFTS: 45

Polyradiculoneuropathy malady

Summaries for Polyradiculoneuropathy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Polyradiculoneuropathy describes a condition in which polyneuropathy and polyradiculopathy occur... more...

MalaCards: Polyradiculoneuropathy is related to chronic inflammatory demyelinating polyradiculoneuropathy and systemic lupus erythematosus. An important gene associated with Polyradiculoneuropathy is PMP22 (peripheral myelin protein 22), and among its related pathways are TGF Beta Signaling Pathway and Cytokines and Inflammatory Response. The compounds cycloheximide and pge2 have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and nervous system.

Aliases & Classifications for Polyradiculoneuropathy

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

polyradiculoneuropathy 8 45 61


External Ids:

Disease Ontology8 DOID:4308
SNOMED-CT57 128078004
MeSH35 D011129

Related Diseases for Polyradiculoneuropathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Polyradiculoneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1chronic inflammatory demyelinating polyradiculoneuropathy31.6MPZ, CCR5, PMP22, IFNB1
2systemic lupus erythematosus30.5CCR5, IFNG, HLA-DRB1, STAT1, IL2, CD40LG
3thyroiditis30.0HLA-DRB1
4acute leukemia30.0STAT1, CXCL12, IL2
5hepatitis c30.0HLA-DRB1, CCR5, IFNG, IFNB1, STAT1, CD40LG
6rabies29.8MPZ
7viral hepatitis29.8STAT1, HLA-DRB1, IFNB1
8factor vii deficiency29.8IFNG, IFNB1, IL2
9graft versus host disease29.8IL2, CCR5, HLA-DRB1, IFNG, CXCL12
10guillain-barr� syndrome10.6
11neuropathy, inflammatory demyelinating10.5
12n syndrome10.3
13multifocal motor neuropathy10.3
14chronic inflammatory demyelinating polyneuropathy10.2
15membranous glomerulonephritis10.1
16lateral sclerosis10.0
17amyotrophic lateral sclerosis10.0
18neurologic diseases10.0
19autonomic dysfunction10.0
20myokymia10.0
21subacute inflammatory demyelinating polyneuropathy10.0
22polyradiculoneuropathy associated with igg/iga/igm monoclonal gammopathy without known antibodies10.0
23cholera10.0IFNB1
24progressive multifocal leukoencephalopathy10.0IFNB1
25mumps10.0STAT1
26lupus erythematosus10.0CD40LG
27rubella10.0CD40LG
28synovitis10.0STAT1
29dengue hemorrhagic fever10.0CD40LG
30multiple myeloma10.0CXCL12
31chronic mucocutaneous candidiasis10.0STAT1
32macroglobulinemia, waldenstrom, somatic10.0CD40LG
33toxoplasmosis10.0CD40LG
34leptospirosis10.0CD40LG
35hemorrhagic fever10.0CD40LG
36cervical cancer10.0STAT1
37polymyositis10.0CCR5
38autoimmune hemolytic anemia10.0CD40LG
39hepatitis e10.0CD40LG
40chagas disease10.0CCR5
41dermatitis10.0IFNG
42primary immunodeficiency disease10.0CD40LG
43wiskott-aldrich syndrome10.0CXCL12
44antiphospholipid syndrome10.0CD40LG
45leishmaniasis10.0IFNG
46aplastic anemia10.0IFNG
47allergic rhinitis10.0IFNG
48myopathy10.0MPZ, PMP22
49proliferative diabetic retinopathy10.0CXCL12
50myelofibrosis10.0CXCL12

Graphical network of the top 20 diseases related to Polyradiculoneuropathy:



Diseases related to polyradiculoneuropathy

Clinical Features for Polyradiculoneuropathy

Drugs & Therapeutics for Polyradiculoneuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Polyradiculoneuropathy

Drug clinical trials:

Search ClinicalTrials for Polyradiculoneuropathy

Search NIH Clinical Center for Polyradiculoneuropathy

Search CenterWatch for Polyradiculoneuropathy

Genetic Tests for Polyradiculoneuropathy

Anatomical Context for Polyradiculoneuropathy

Animal Models for Polyradiculoneuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Polyradiculoneuropathy

Sources:
51PubMed
See all sources

Articles related to Polyradiculoneuropathy:

(show top 50)    (show all 436)
idTitleAuthorsYear
1
Treatment dependence in chronic inflammatory demyelinating polyradiculoneuropathy: is it related to disease phenotype or to the therapy used? (24336789)
2013
2
Recurrent acute inflammatory demyelinating polyradiculoneuropathy following R-CHOP treatment for non-Hodgkin lymphoma. (23543974)
2013
3
Chronic inflammatory demyelinating polyradiculoneuropathy. (23623582)
2013
4
Sarcoidosis presenting as acute inflammatory demyelinating polyradiculoneuropathy. (21254101)
2011
5
The effect of IgG levels on the number of natural killer cells and their Fc receptors in chronic inflammatory demyelinating polyradiculoneuropathy. (21219545)
2011
6
Helicobacter pylori may play an important role in both axonal type Guillain-BarrAc syndrome and acute inflammatory demyelinating polyradiculoneuropathy. (21316838)
2011
7
Safety and tolerability of immune globulin intravenous in chronic inflammatory demyelinating polyradiculoneuropathy. (20837852)
2010
8
European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society - first revision. (20456730)
2010
9
Acute polyradiculoneuropathy following wasp sting. (19934578)
2009
10
pSTAT1, pSTAT3, and T-bet as markers of disease activity in chronic inflammatory demyelinating polyradiculoneuropathy. (19691533)
2009
11
Campylobacter jejuni abscess, encephalomyelitis, and acute polyradiculoneuropathy. (19768757)
2009
12
Diabetic thoracic polyradiculoneuropathy (DTP) following normalization of blood glucose post-pancreatic transplantation. (19573126)
2009
13
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy: a multiracial Asian perspective. (18505408)
2008
14
Chronic inflammatory demyelinating polyradiculoneuropathy: new views and guidelines. (16221282)
2005
15
Association between Helicobacter pylori infection and acute inflammatory demyelinating polyradiculoneuropathy. (15679702)
2005
16
European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. (16221283)
2005
17
Forme fruste manifestations of chronic inflammatory demyelinating polyradiculoneuropathy. (15210548)
2004
18
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with hypertrophic spinal radiculopathy mimicking neurofibromatosis. (12536230)
2003
19
Waldenstrom's Macroglobulinaemia Presenting as Demyelinating Polyradiculoneuropathy. (24326654)
2002
20
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review. (12849334)
2002
21
P0 protein is a target antigen in chronic inflammatory demyelinating polyradiculoneuropathy. (11558784)
2001
22
Chronic inflammatory demyelinating polyradiculoneuropathy. (11558782)
2001
23
Hepatocellular carcinoma presenting with chronic inflammatory demyelinating polyradiculoneuropathy. (11258560)
2000
24
Multifocal polyradiculoneuropathy and carcinoma of the thymus. (10500276)
1999
25
Polyradiculoneuropathy revealing a solitary plasmacytoma of the ilium. A new case-report. (10339780)
1999
26
Randomized trial of interferon beta-1a in chronic inflammatory demyelinating polyradiculoneuropathy. (10408537)
1999
27
Trigeminal nerve hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy. (9818882)
1998
28
Chronic inflammatory demyelinating polyradiculoneuropathy in children: II. Long-term follow-up, with comparison to adults. (9390670)
1997
29
Acute inflammatory demyelinating polyradiculoneuropathy following antirabies vaccine. (9251474)
1996
30
Prolonged remission of SLE-associated polyradiculoneuropathy after a single course of intravenous immunoglobulin. (8668963)
1996
31
Polyradiculoneuropathy induced by gold therapy. (7552214)
1995
32
Human immunodeficiency virus-associated motor axonal polyradiculoneuropathy. (8257309)
1993
33
Prognosis in long-term immunosuppressive treatment of refractory chronic inflammatory demyelinating polyradiculoneuropathy. (1738011)
1992
34
Chronic inflammatory demyelinating polyradiculoneuropathy: comparison of patients with and without an associated monoclonal gammopathy. (1603342)
1992
35
Clinical signs of amyotrophic lateral sclerosis developing after polyradiculoneuropathy associated with amitriptyline. (2108779)
1990
36
Sural nerve biopsy in chronic inflammatory demyelinating polyradiculoneuropathy. (2770778)
1989
37
Response of CSF IgG to steroids in an 18-month-old with chronic inflammatory polyradiculoneuropathy. (2766546)
1989
38
SSEP and F-wave studies in acute inflammatory demyelinating polyradiculoneuropathy. (2779603)
1989
39
Post infective polyradiculoneuropathy with bilateral recurrent laryngeal nerve palsy. (2632572)
1989
40
Chronic inflammatory demyelinating polyradiculoneuropathy: features and prognostic factors with corticosteroid therapy. (3416887)
1988
41
Numbness of the tip of the tongue as the presenting symptom of chronic inflammatory polyradiculoneuropathy. (3340307)
1988
42
Chronic nephrotoxicity complicating cyclosporine treatment of chronic inflammatory demyelinating polyradiculoneuropathy. (3796829)
1987
43
Chronic inflammatory demyelinating polyradiculoneuropathy associated with pregnancy. (3030186)
1987
44
Early relapses after plasma exchange in acute inflammatory polyradiculoneuropathy. (2877308)
1986
45
Plasma exchange in chronic inflammatory demyelinating polyradiculoneuropathy. (16758599)
1985
46
Idiopathic inflammatory polyradiculoneuropathy: evaluation of clinical and laboratory data and therapeutic considerations. (6862843)
1983
47
Lymphocyte studies in a patient with chronic polyradiculoneuropathy. (6214729)
1982
48
Plasma exchange in polyradiculoneuropathy. (7425583)
1980
49
Facial myokymia with polyradiculoneuropathy. (571564)
1979
50
Chronic inflammatory polyradiculoneuropathy. (1186294)
1975

Genetic Variations for Polyradiculoneuropathy

Expression for genes affiliated with Polyradiculoneuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyradiculoneuropathy

Search GEO for disease gene expression data for Polyradiculoneuropathy.

Pathways for genes affiliated with Polyradiculoneuropathy

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 4Cell Signaling Technology, 12EMD Millipore, 60Tocris Bioscience, 52QIAGEN, 53R&D Systems
See all sources

Pathways related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3STAT1
210.2HLA-DRB1
310.0STAT1, IFNG
49.8HLA-DRB1, IFNB1
5
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9.7CXCL12, STAT1, STAT3
6
Development Thrombopoetin signaling via JAK-STAT pathway
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9.7IFNG, STAT3, STAT1
7
Immune response IFN gamma signaling pathway
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9.7IFNG, STAT3, STAT1
8
Hide members
9.6IL2, STAT1, STAT3
99.6IL2, CD40LG, IFNG
109.6STAT1, IFNB1, IFNG
119.6IFNG, IFNB1, STAT1
129.5SH2D2A, STAT1, STAT3
139.5IFNG, PRF1, IL2
14
Hide members
9.5CCR5, IFNG, STAT3, STAT1
159.4HLA-DRB1, STAT3, STAT1, CXCL12
169.4IFNG, IFNB1, IL2
179.4IFNG, STAT1, TBX21, IL2
18
Hide members
9.4IL2, CD40LG, TBX21, IFNG
19
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9.4CCR5, IFNG, CD40LG, IL2
20
Development PDGF signaling via STATs and NF-kB
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9.4IL2, STAT1, STAT3, IFNG
21
Hide members
9.4IL2, STAT1, STAT3, IFNG
229.3IL2, STAT1, STAT3, HLA-DRB1
239.3PMP22, MBP, MPZ
24
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.2MBP, STAT3, STAT1
25
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9.1IFNG, STAT3, STAT1, TBX21, IL2
26
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9.1IFNG, HLA-DRB1, PRF1, CD40LG, CXCL12
27
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9.1IFNG, HLA-DRB1, STAT3, STAT1, IL2
28
Hide members
9.0CCR5, HLA-DRB1, STAT3, STAT1, TBX21, CD40LG
29
Hide members
9.0IL2, STAT1, STAT3, IFNB1, IFNG
309.0IFNG, IFNB1, STAT3, STAT1, IL2
318.9CCL19, CCL21, CD40LG, CXCL12
32
Hide members
8.8CCL19, CCL21, CCR5, CXCL12
338.8CCL19, CCL21, CCR5, CXCL12
348.7IL2, TBX21, PRF1, STAT3, HLA-DRB1, IFNG
35
Apoptosis and survival Lymphotoxin-beta receptor signaling
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8.7IL2, CXCL12, CCL21, CCL19
36
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8.7IFNG, IFNB1, PRF1, SH2D2A, IL2
37
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8.6IFNG, IFNB1, HLA-DRB1, STAT3, STAT1, IL2
38
Hide members
8.6IFNG, IFNB1, HLA-DRB1, STAT3, STAT1, IL2
39
Hide members
8.6CCR5, IFNG, HLA-DRB1, STAT3, STAT1, TBX21
40
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8.6CCL19, CCL21, IFNB1, IL2
41
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8.4CCL19, CCL21, CCR5, IFNB1, CXCL12
42
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8.4IFNG, IFNB1, HLA-DRB1, STAT3, STAT1, CD40LG
43
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8.3CCL19, CCL21, CCR5, STAT3, STAT1, CXCL12
44
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8.3CCL19, CCL21, CCR5, STAT3, STAT1, CXCL12
45
Hide members
8.0CCL19, CCL21, CCR5, STAT3, STAT1, CXCL12
46
Hide members
8.0CCL19, CCL21, CCR5, STAT3, STAT1, CXCL12

Compounds for genes affiliated with Polyradiculoneuropathy

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.0CXCL12, IFNB1, STAT1
2pge24510.0IL2, CCL19
3gold sodium thiomalate459.8IFNG, HLA-DRB1, IL2
4mdms459.8CCR5, CXCL12, STAT1
5serine459.7PMP22, STAT3, MPZ, STAT1, CCR5
6heparin45 29 11 2412.7IFNB1, CCR5, CXCL12, CD40LG
7dexamethasone45 50 29 1112.7IFNB1, STAT3, CD40LG, CXCL12
8retinyl palmitate45 2410.7IL2, STAT3, IFNB1
9indomethacin45 60 29 1112.7MBP, IFNB1
10rituximab45 50 1111.7STAT3, CD40LG, IL2, CXCL12
11auranofin45 60 29 1112.7IL2, IFNG, ALB
12aspartate459.6CD40LG, MPZ, PMP22, ALB, CCR5
13mycophenolate mofetil45 50 1111.6IFNG, ALB, IL2, CD40LG
142,5-oligoadenylate459.6STAT1, IFNB1, IFNG, IL2
15il 10459.5CCR5, IL2, IFNB1, IFNG
16valsartan45 60 29 1112.5ALB, STAT3, STAT1
17neopterin459.5IFNB1, IFNG, CD40LG, IL2
18galactosylceramide459.5CXCL12, CCR5, MBP
19thalidomide45 50 60 1112.5IL2, CD40LG, STAT3, IFNG
20glutamate459.4MBP, CD40LG
21teck459.4CXCL12, CCL21, CCL19
22polyinosinic-polycytidylic acid459.4IFNB1, IFNG, STAT3, STAT1, IL2
235-aza-2deoxycytidine459.4STAT3, IFNB1, IFNG, CXCL12, STAT1
24ccl445 2910.4CCR5, CXCL12, CCL21, IFNB1
25ribavirin45 50 1111.3IFNG, CCR5, STAT3, CD40LG, STAT1, IL2
26mezerein459.3IFNG, MBP, IFNB1
27vegf459.3STAT3, CXCL12, STAT1, SH2D2A, IFNB1
28ganglioside459.2CD40LG, MPZ, MBP, PMP22
29zidovudine45 1110.2ALB, CCR5, IFNB1, CXCL12, IL2
30larc459.2CXCL12, CCR5, CCL19, CCL21
31sulfamethoxazole45 50 1111.2IL2, ALB, CD40LG
32herbimycin a45 6010.2IFNG, STAT1, CD40LG, CXCL12, IL2, IFNB1
33ifn-alpha459.1STAT1, IFNG, IFNB1, STAT3, CXCL12, IL2
345fluorouracil459.1IFNG, STAT3, CXCL12, IL2, IFNB1
35rapamycin459.0CCR5, STAT3, STAT1, IFNG, CD40LG, CXCL12
36cyclosporin a45 29 6011.0IFNG, MBP, STAT3, STAT1, CD40LG
37rantes458.9CD40LG, IL2, CXCL12, STAT1, STAT3, IFNB1
38genistein45 29 60 2 11 2413.9CD40LG, CXCL12, STAT1, STAT3, IFNB1, IFNG
39actinomycin d458.7STAT3, IFNG, CD40LG, STAT1, IL2, CCR5
40tarc458.6CCL19, CXCL12, IFNB1, IFNG, CCR5, CCL21
41ccl345 299.6CCL19, CCL21, CXCL12, IFNB1, IFNG, CCR5
42cholesterol45 29 11 2411.6STAT3, CCR5, PRF1, CXCL12, ALB, MPZ
43glatiramer acetate45 119.6IFNG, IFNB1, MBP, HLA-DRB1, MPZ, IL2
44ivig458.5CCR5, IFNB1, MBP, CD40LG, ALB, IFNG
45cisplatin45 50 60 1111.3STAT3, IFNB1, IL2, STAT1, CD40LG, MBP
46thymidine45 249.2IL2, CXCL12, STAT3, MBP, IFNB1, IFNG
47retinoic acid45 249.1CCR5, STAT3, MBP, PMP22, IFNG, STAT1
48arginine457.9CXCL12, PMP22, MBP, IFNG, CCR5, STAT3
49cysteine457.6PMP22, ALB, CD40LG, STAT1, STAT3, MBP
50tyrosine457.3CXCL12, HLA-DRB1, STAT3, STAT1, MPZ, SH2D2A

GO Terms for genes affiliated with Polyradiculoneuropathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:0432189.5MBP, PMP22
2external side of plasma membraneGO:0098979.1CCR5, IFNG, HLA-DRB1, CD40LG, CXCL12
3extracellular spaceGO:0056157.4ALB, CCL19, CCL21, IFNG, IFNB1, CD40LG
4extracellular regionGO:0055767.1CCL19, CCL21, IFNG, IFNB1, PRF1, CXCL12

Biological processes related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of metanephric nephron tubule epithelial cell differentiationGO:07230810.3IFNG, STAT1
2negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:00334010.3IFNG, STAT1
3positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:03314110.1IFNG, IFNB1
4positive regulation of isotype switching to IgG isotypesGO:04830410.0IFNG, TBX21, IL2
5interferon-gamma-mediated signaling pathwayGO:0603339.8STAT1, HLA-DRB1, IFNG
6positive regulation of interleukin-12 productionGO:0327359.7CD40LG, IFNG, CCL19
7positive regulation of glycoprotein biosynthetic processGO:0105609.6CCL19, CCL21
8immunological synapse formationGO:0017719.6CCL21, CCL19
9establishment of T cell polarityGO:0017689.6CCL19, CCL21
10response to prostaglandin E stimulusGO:0346959.6CCL21, CCL19
11B cell proliferationGO:0421009.5IFNB1, CD40LG
12positive regulation of dendritic cell antigen processing and presentationGO:0026069.5CCL21, CCL19
13defense response to virusGO:0516079.5PRF1, STAT1, IFNB1, IFNG
14negative regulation of leukocyte apoptotic processGO:20001079.4CCL19, CCL21, CXCL12
15positive regulation of chemotaxisGO:0509219.4CCL21, CCL19
16dendritic cell chemotaxisGO:0024079.4CCR5, CCL21, CCL19
17positive regulation of cell motilityGO:20001479.3CCL21, CCL19
18cytokine-mediated signaling pathwayGO:0192219.3IFNG, IFNB1, HLA-DRB1, STAT3, STAT1
19positive regulation of receptor-mediated endocytosisGO:0482609.2CCL19, CCL21
20membrane organizationGO:0610249.2MBP, PMP2
21T cell costimulationGO:0312959.2CCL19, CCL21, HLA-DRB1
22response to virusGO:0096159.1CCL19, IFNG, IFNB1, TBX21, CXCL12
23inflammatory responseGO:0069548.8CD40LG, CCR5, CCL21, CCL19
24immune responseGO:0069557.7IL2, CXCL12, HLA-DRB1, MBP, CCR5, CCL21

Molecular functions related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR7 chemokine receptor bindingGO:0317329.2CCL21, CCL19
2chemokine activityGO:0080099.1CXCL12, CCL21, CCL19
3cytokine activityGO:0051258.9IL2, CD40LG, IFNB1, IFNG

Products for genes affiliated with Polyradiculoneuropathy

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Sources for Polyradiculoneuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet