MCID: PLY020
MIFTS: 45

Polyradiculoneuropathy malady

Categories: Neuronal diseases

Aliases & Classifications for Polyradiculoneuropathy

Aliases & Descriptions for Polyradiculoneuropathy:

Name: Polyradiculoneuropathy 12 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4308
MeSH 42 D011129
SNOMED-CT 64 128078004
UMLS 69 C0032587

Summaries for Polyradiculoneuropathy

MalaCards based summary : Polyradiculoneuropathy is related to chronic inflammatory demyelinating polyradiculoneuropathy and polyradiculoneuropathy associated with igg/iga/igm monoclonal gammopathy without known antibodies. An important gene associated with Polyradiculoneuropathy is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Immunoglobulins and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and brain, and related phenotypes are homeostasis/metabolism and cellular

Wikipedia : 71 Polyradiculoneuropathy describes a condition in which polyneuropathy and polyradiculopathy occur... more...

Related Diseases for Polyradiculoneuropathy

Diseases related to Polyradiculoneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
id Related Disease Score Top Affiliating Genes
1 chronic inflammatory demyelinating polyradiculoneuropathy 12.1
2 polyradiculoneuropathy associated with igg/iga/igm monoclonal gammopathy without known antibodies 11.8
3 chronic inflammatory demyelinating polyneuropathy 11.5
4 neuropathy, inflammatory demyelinating 11.1
5 guillain-barre syndrome 11.1
6 chronic inflammatory demyelinating polyneuritis 10.9
7 subacute inflammatory demyelinating polyneuropathy 10.9
8 chronic polyradiculoneuritis 10.8
9 hereditary type 2 neuropathy 10.3 MPZ PMP22
10 chrna1-related congenital myasthenic syndrome 10.3 MPZ PMP22
11 surfactant metabolism dysfunction, pulmonary, 2 10.3 MPZ PMP22
12 hypertonia 10.3 MPZ PMP22
13 pneumonic plague 10.3 MPZ PMP22
14 craniorachischisis 10.3 MBP MPZ PMP22
15 deafness, autosomal recessive 76 10.2 MPZ PMP22
16 charcot-marie-tooth disease, type 1e 10.2 MBP MPZ PMP22
17 mohr-tranebjaerg syndrome 10.2 MBP MPZ PMP22
18 asymptomatic neurosyphilis 10.2 IFNG IL10
19 classic galactosemia and clinical variant galactosemia 10.2 MPZ PMP22
20 korsakoff's amnesic syndrome 10.2 MBP MPZ PMP22
21 uterine ligament serous adenocarcinoma 10.2 ALB MPZ PMP22
22 nguyen syndrome 10.2 IL10 IL17A
23 white piedra 10.2 MBP MPZ PMP22
24 ciliary discoordination, due to random ciliary orientation 10.2 ALB IFNG IL10
25 rosacea 10.2 ALB IFNG IL10
26 hereditary alpha tryptasemia syndrome 10.2 ALB IFNG IL10
27 subungual glomus tumor 10.2 IFNG TBX21
28 parkinson disease 11 10.2 IFNG IL10 IL17A
29 plummer's disease 10.2 ALB IFNG IL10
30 denys-drash syndrome 10.2 IFNG IL10 IL17A
31 orbital osteomyelitis 10.2 IFNG IL10 IL17A
32 loiasis 10.2 IFNG IL10 IL17A
33 depressed scar 10.2 ALB IFNG IL10
34 disease of mental health 10.2 IFNG IL10 IL17A
35 trichomalacia 10.2 IL10 IL17A MBP
36 gastric dilatation 10.2 IL10 IL17A MBP
37 paratyphoid fever 10.2 ALB IFNG IL10
38 follicular adenoma 10.2 IFNG IL10 IL17A
39 motor peripheral neuropathy 10.2 IFNG IL10 IL17A
40 anterior foramen magnum meningioma 10.2 ALB IFNG IL10
41 liver inflammatory pseudotumor 10.2 ALB IFNG IL10
42 burns 10.1 IFNG IL10 IL17A
43 balkan nephropathy 10.1 IFNG IL10 IL17A
44 uterus interstitial leiomyoma 10.1 ALB IFNG IL10
45 neonatal stroke 10.1 IFNG IL10 MBP
46 parasitic protozoa infectious disease 10.1 IFNG IL10 IL17A
47 sclerosing adenosis of breast 10.1 ALB IFNG IL10
48 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.1 IFNG IL10
49 chronic gonorrhea of cervix 10.1 IFNG IL10 IL17A
50 benign eccrine breast spiradenoma 10.1 IFNG IL10 STAT3

Graphical network of the top 20 diseases related to Polyradiculoneuropathy:



Diseases related to Polyradiculoneuropathy

Symptoms & Phenotypes for Polyradiculoneuropathy

MGI Mouse Phenotypes related to Polyradiculoneuropathy:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.23 ALB CXCR4 IFNB1 IFNG IL10 IL17A
2 cellular MP:0005384 10.22 ALB CXCR4 IFNG PRF1 STAT3 TBX21
3 hematopoietic system MP:0005397 10.22 CCL5 CXCR4 IFNB1 IFNG IL10 IL17A
4 immune system MP:0005387 10.17 CCL5 CXCR4 IFNB1 IFNG IL10 IL17A
5 endocrine/exocrine gland MP:0005379 10.1 ALB CXCR4 IFNG IL10 IL17A PRF1
6 mortality/aging MP:0010768 10.1 ALB CXCR4 IFNG IL10 IL17A MBP
7 digestive/alimentary MP:0005381 10.05 ALB CXCR4 IFNG IL10 IL17A STAT3
8 nervous system MP:0003631 10 IFNG IL10 MBP MPZ PMP2 PMP22
9 neoplasm MP:0002006 9.92 IL10 PRF1 STAT3 TBX21 ALB CXCR4
10 muscle MP:0005369 9.85 ALB CXCR4 IFNG IL10 PMP22 STAT3
11 normal MP:0002873 9.7 IL10 MBP PRF1 STAT3 ALB IFNB1
12 reproductive system MP:0005389 9.56 CXCR4 IFNG IL10 MBP MPZ PMP22
13 respiratory system MP:0005388 9.1 CXCR4 IFNG IL10 IL17A STAT3 TBX21

Drugs & Therapeutics for Polyradiculoneuropathy

Drugs for Polyradiculoneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 4,Phase 3,Phase 2
2 gamma-Globulins Phase 4,Phase 3,Phase 2
3 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
4 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
5 Antibodies Phase 4,Phase 3,Phase 2
6
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
7
Mycophenolic acid Approved Phase 3 24280-93-1 446541
8
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
9
Glycine Approved, Nutraceutical, Vet_approved Phase 3 56-40-6 750
10 glucocorticoids Phase 3
11 Hormone Antagonists Phase 3,Phase 2
12 Hormones Phase 3,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
14 Immunoglobulin G Phase 3
15 Potassium Channel Blockers Phase 3,Phase 2
16 3,4-diaminopyridine Phase 3
17 Immunosuppressive Agents Phase 3,Phase 2
18 Fingolimod Hydrochloride Phase 3
19 Anti-Inflammatory Agents Phase 3
20 Antineoplastic Agents, Hormonal Phase 3
21 Pharmaceutical Solutions Phase 3,Phase 2
22 Anti-Bacterial Agents Phase 3
23 Antibiotics, Antitubercular Phase 3
24
4-Aminopyridine Approved Phase 2 504-24-5 1727
25
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
27 Complement System Proteins Phase 2
28 interferons Phase 2
29 Adjuvants, Immunologic Phase 2
30 Thioctic Acid Phase 2
31 Trace Elements Phase 2
32 Vitamin B Complex Phase 2
33 Vitamins Phase 2
34 Anti-Infective Agents Phase 2
35 Protective Agents Phase 2
36 Interferon-beta Phase 2
37 Micronutrients Phase 2
38 Antiviral Agents Phase 2
39 Antioxidants Phase 2
40 Folate Nutraceutical Phase 2
41 Alpha-lipoic Acid Nutraceutical Phase 2
42 Vitamin B9 Nutraceutical Phase 2
43 Chelating Agents
44 Vaccines
45 Anticoagulants
46 Calcium, Dietary
47 Antibodies, Anti-Idiotypic
48 Citrate Nutraceutical
49
Citric Acid Nutraceutical, Vet_approved 77-92-9 311

Interventional clinical trials:

(show top 50) (show all 62)
id Name Status NCT ID Phase
1 IVIg for Demyelination in Diabetes Mellitus Recruiting NCT02372149 Phase 4
2 Alemtuzumab in Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIPD) Withdrawn NCT01757574 Phase 4
3 Evaluate Efficacy and Safety of Fingolimod 0.5 mg Orally Once Daily Versus Placebo in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients. Completed NCT01625182 Phase 3
4 Phase III Randomized, Double-Blind, Placebo-Controlled Study of 3,4-Diaminopyridine for Demyelinating Polyneuropathy Completed NCT00004939 Phase 3
5 Phase III Multicenter Double Blind Controlled Trial of Human Immune Globulin Therapy in Previously Untreated Patients With Chronic Inflammatory Demyelinating Neuropathy Completed NCT00004286 Phase 3
6 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Immune Globulin for Chronic Inflammatory Demyelinating Polyneuropathy Completed NCT00004772 Phase 3
7 Immune Globulin Intravenous (IGIV) For Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Completed NCT00220740 Phase 3
8 Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Treatment With Subcutaneous Immunoglobulin (IgPro20) Completed NCT01545076 Phase 3
9 Phase III Clinical Trial of NPB-01maintenance Therapy in Patients With Chronic Inflammatory Demyelinating Polyneuropathy. Completed NCT01824251 Phase 3
10 Randomized Open-label Trial to Compare Efficacy and Tolerance of Corticosteroids and IVIg Completed NCT01349270 Phase 3
11 Study of Efficacy and Safety of Privigen in Subjects With Chronic Inflammatory Demyelinating Polyneuropathy Completed NCT01184846 Phase 3
12 Efficacy and Safety Study of GB-0998 for Guillain-Barré Syndrome Completed NCT02342184 Phase 3
13 Phase III Clinical Trial of NPB-01 in Patients With Guillain-Barré Syndrome Completed NCT02221271 Phase 3
14 Long-Term Tolerability and Safety of HYQVIA/HyQvia in CIDP Recruiting NCT02955355 Phase 3
15 Phase III Efficacy, Safety, and Tolerability Study of HYQVIA/HyQvia and GAMMAGARD LIQUID/KIOVIG in CIDP Recruiting NCT02549170 Phase 3
16 Efficacy and Safety Study of I10E in Treatment of Patients With CIDP Recruiting NCT02293460 Phase 3
17 Efficacy and Safety Study of I10E in the Maintenance Treatment of Patients With CIDP: Extension of PRISM Study I10E-1302 Recruiting NCT02317562 Phase 3
18 Extension Study of Maintenance Treatment With Subcutaneous Immunoglobulin (IgPro20) for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Active, not recruiting NCT02027701 Phase 3
19 Interest of Mycophenolate for CIDP Weaning Active, not recruiting NCT02494505 Phase 3
20 Panzyga in CIDP Administered at Different Infusion Rates Not yet recruiting NCT03166527 Phase 3
21 Safety and Efficacy Study of Three Different Dosages of NewGam in Patients With CIDP Terminated NCT01225276 Phase 2, Phase 3
22 Inhibition of Complement Activation (Eculizumab) in Guillain-Barre Syndrome Study Unknown status NCT02029378 Phase 2
23 Subcutaneous Immunoglobulin Treatment of Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Completed NCT01017159 Phase 2
24 Safety and Efficacy of Avonex in Subjects With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Completed NCT00099489 Phase 2
25 Lipoic Acid to Treat Chronic Inflammatory Demyelinating Polyneuropathy Completed NCT00962429 Phase 2
26 Intravenous Immunoglobulin (IVIg) for the Treatment of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Completed NCT00001287 Phase 2
27 Assessment of Chronic Guillain-Barre Syndrome Improvement With Use of 4-aminopyridine Completed NCT00056810 Phase 2
28 Early Mechanical Ventilation for Guillain Barré Syndrome Completed NCT00167622 Phase 2
29 SERENDEM : MD1003 in Patients Suffering From Demyelinating Neuropathies, an Open Label Pilot Study Recruiting NCT02967679 Phase 1, Phase 2
30 Small Volume Plasma Exchange (SVPE) for Guillain-Barré Syndrome (GBS) Patients Recruiting NCT02780570 Phase 2
31 Hematopoietic Stem Cell Transplantation in Chronic Inflammatory Demyelinating Polyneuropathy Active, not recruiting NCT00278629 Phase 2
32 Pilot Study of Acthar® Gel in Chronic Inflammatory Demyelinating Neuropathy Withdrawn NCT02574962 Phase 2
33 High-dose Cyclophosphamide for Moderate to Severe Refractory Chronic Inflammatory Demyelinating Polyneuropathy Withdrawn NCT01236456 Phase 2
34 Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy Unknown status NCT01379833
35 Perception and Multisensory Integration in Neurological Patients Using fMRI Unknown status NCT01469858
36 Change of Nerve Conduction Properties in IVIg Dependent Neuropathies Unknown status NCT01655394
37 The Changes of Cytokines in Guillain Barré Syndrome: the Correlation With Clinical Manifestations and Skin Innervation Unknown status NCT00173199
38 Study of CIDP Patients During IVIG Treatment Completed NCT00305266
39 MRI in Diagnosing and Monitoring CIDP Completed NCT02017769
40 Effect of Resistance and Aerobic Exercise in CIDP or MMN Completed NCT02121678
41 Immunoglobulin Dosage and Administration Form in CIDP and MMN Completed NCT02111590
42 Magnetic Resonance Diagnostics of Diabetic Peripheral Neuropathy Completed NCT01847937
43 Effects of Robotic-assisted Gait Training In Non-Ambulatory Patients After Guillain-Barré Syndrome Completed NCT02883270
44 Regional Citrate Anticoagulation in Plasma Exchange Treatment Completed NCT01370200
45 Intravenous Immunoglobulin (IVIG) Versus Plasma Exchange (PE) for Ventilated Children With Guillain Barre Syndrome (GBS) Completed NCT01306578
46 Safety Study of GBS Following Menactra Meningococcal Vaccination Completed NCT00575653
47 Brain Computer Interface for Communication in ICU: a Feasibility Study Completed NCT01005524
48 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328
49 Prospective Study on Swallowing/Breathing Interactions in Severe Guillain Barre Syndrome. Completed NCT01024088
50 Biomark Study: Predict Intravenous Immunoglobulin Responders in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Recruiting NCT02629796

Search NIH Clinical Center for Polyradiculoneuropathy

Cochrane evidence based reviews: polyradiculoneuropathy

Genetic Tests for Polyradiculoneuropathy

Anatomical Context for Polyradiculoneuropathy

MalaCards organs/tissues related to Polyradiculoneuropathy:

39
T Cells, Spinal Cord, Brain, Thyroid, Tongue, Kidney, Skin

Publications for Polyradiculoneuropathy

Articles related to Polyradiculoneuropathy:

(show top 50) (show all 496)
id Title Authors Year
1
Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews. ( 28084646 )
2017
2
Intravenous Immunoglobulins Lower Inflammatory Gene Expression in Skin Biopsies of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients. ( 27286956 )
2016
3
Human Endogenous Retrovirus and Neuroinflammation in Chronic Inflammatory Demyelinating Polyradiculoneuropathy. ( 27211560 )
2016
4
A case of chronic inflammatory demyelinating polyradiculoneuropathy after treatment with pegylated interferon I+-2a in a patient with chronic hepatitis B virus infection. ( 27680223 )
2016
5
Fatigue, Pain, Anxiety and Depression in Guillain-BarrAc Syndrome and Chronic Inflammatory Demyelinating Polyradiculoneuropathy. ( 27077919 )
2016
6
Acute inflammatory demyelinating polyradiculoneuropathy in a newborn infant. ( 27238765 )
2016
7
A case of a 17-year-old male with neurofascin-155 antibody-positive chronic inflammatory demyelinating polyradiculoneuropathy presenting with tremor and ataxia. ( 27580761 )
2016
8
Chronic inflammatory demyelinating polyradiculoneuropathy: A new animal model for new therapeutic targets. ( 27838091 )
2016
9
Stance Postural Strategies in Patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy. ( 26977594 )
2016
10
Cerebral infarction following subcutaneous immunoglobulin therapy for chronic inflammatory demyelinating polyradiculoneuropathy. ( 26873805 )
2016
11
A Bodybuilder With Weak Hands and Feet: Corticosteroid-Responsive Pure Motor Chronic Inflammatory Demyelinating Polyradiculoneuropathy Following Anabolic Steroid Use. ( 27438336 )
2016
12
IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay. ( 27852440 )
2016
13
Evolution of hepatitis E virus-associated meningo-polyradiculoneuropathy on ribavirin. ( 27470489 )
2016
14
Motor unit number index (MUNIX): Is it relevant in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)? ( 26750580 )
2016
15
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): Clinical Features, Diagnosis, and Current Treatment Strategies. ( 27902997 )
2016
16
Economic Evaluation of Intravenous Immunoglobulin plus Corticosteroids for the Treatment of Steroid-Resistant Chronic Inflammatory Demyelinating Polyradiculoneuropathy in Thailand. ( 27113227 )
2016
17
Giant nerves in chronic inflammatory polyradiculoneuropathy. ( 27463360 )
2016
18
Peripheral Nerve Ultrasonography in Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy: Correlations with Clinical and Neurophysiological Data. ( 27313890 )
2016
19
Immunomodulation of inflammatory leukocyte markers during intravenous immunoglobulin treatment associated with clinical efficacy in chronic inflammatory demyelinating polyradiculoneuropathy. ( 27781132 )
2016
20
Intravenous immunoglobulin treatment in chronic inflammatory demyelinating polyradiculoneuropathy, a time to start and a time to stop. ( 27241239 )
2016
21
Improving the management of chronic inflammatory demyelinating polyradiculoneuropathy. ( 27230584 )
2016
22
Nivolumab-induced chronic inflammatory demyelinating polyradiculoneuropathy mimicking rapid-onset Guillain-BarrAc syndrome: a case report. ( 27380808 )
2016
23
Transcriptome Analysis of Peripheral Blood in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients Identifies TNFR1 and TLR Pathways in the IVIg Response. ( 27175635 )
2016
24
A case of severe chronic inflammatory demyelinating polyradiculoneuropathy with monoclonal gammopathy of undetermined significance with alternating immunoglobulin class to IgM from IgA. ( 27580763 )
2016
25
Multiple Myeloma Associated Chronic Inflammatory Demyelinating Polyradiculoneuropathy: The Importance of Continued Surveillance. ( 28070468 )
2016
26
Pembrolizumab-Induced Demyelinating Polyradiculoneuropathy. ( 27468083 )
2016
27
Triple-stimulation technique improves the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy. ( 25571892 )
2015
28
Relapse with Dysphagia in a Case of Chronic Inflammatory Demyelinating Polyradiculoneuropathy. ( 26179538 )
2015
29
Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype. ( 25677463 )
2015
30
Plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy. ( 26305459 )
2015
31
Steroids for chronic inflammatory demyelinating polyradiculoneuropathy: evidence base and clinical practice. ( 26437234 )
2015
32
Which criteria for research in chronic inflammatory demyelinating polyradiculoneuropathy? an analysis of current practice. ( 25354388 )
2015
33
Pupils in Acute Inflammatory Demyelinating Polyradiculoneuropathy Different From Adies Pupils. ( 26153043 )
2015
34
Diagnosis of atypical forms of chronic inflammatory demyelinating polyradiculoneuropathy: a practical overview based on some case studies. ( 26392214 )
2015
35
The diagnostic value of MRI in pediatric chronic inflammatory demyelinating polyradiculoneuropathy. ( 25972306 )
2015
36
Chronic inflammatory demyelinating polyradiculoneuropathy with cranial nerves hypertrophy, thyroid-related orbitopathy and IgG monoclonal gammopathy: a case report. ( 25647292 )
2015
37
Acute myeloid leucaemia presenting as a rapidly progressive polyradiculoneuropathy. ( 26581698 )
2015
38
Chronic inflammatory demyelinating polyradiculoneuropathy with cholesterol deposits in a dog. ( 26450833 )
2015
39
New insights into the management of chronic inflammatory demyelinating polyradiculoneuropathy. ( 26107324 )
2015
40
Severe acute inflammatory demyelinating polyradiculoneuropathy with persistent weakness associated with tumor-like nerve root enlargement. ( 25996968 )
2015
41
Long-term Immunoglobulin therapy for chronic inflammatory demyelinating polyradiculoneuropathy. ( 25556954 )
2015
42
Update on the treatment of chronic inflammatory demyelinating polyradiculoneuropathy. ( 26203970 )
2015
43
The frequencies of Killer immunoglobulin-like receptors and their HLA ligands in chronic inflammatory demyelinating polyradiculoneuropathy are similar to those in Guillian Barre syndrome but differ from those of controls, suggesting a role for NK cells in pathogenesis. ( 26198918 )
2015
44
Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy. ( 25561247 )
2015
45
Primary Neurolymphomatosis Presenting With Polyradiculoneuropathy Affecting One Lower Limb. ( 26301373 )
2015
46
Characteristic MRI features of chronic inflammatory demyelinating polyradiculoneuropathy. ( 25687202 )
2015
47
Maintenace therapy in chronic inflammatory demyelinating polyradiculoneuropathy. ( 26088325 )
2015
48
Leukodystrophy presenting as acute-onset polyradiculoneuropathy. ( 24685010 )
2014
49
Severity and patterns of blood-nerve barrier breakdown in patients with chronic inflammatory demyelinating polyradiculoneuropathy: correlations with clinical subtypes. ( 25105500 )
2014
50
Intravenous immunoglobulin response in treatment-naA^ve chronic inflammatory demyelinating polyradiculoneuropathy. ( 25515502 )
2014

Variations for Polyradiculoneuropathy

Expression for Polyradiculoneuropathy

Search GEO for disease gene expression data for Polyradiculoneuropathy.

Pathways for Polyradiculoneuropathy

Pathways related to Polyradiculoneuropathy according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 CCL5 CXCR4 IFNB1 IFNG IL10 IL17A
2
Show member pathways
13.37 CCL5 CXCR4 IFNB1 IFNG IL10 IL17A
3
Show member pathways
13.2 CCL5 IFNB1 IFNG IL10 IL17A STAT3
4
Show member pathways
12.73 CCL5 IFNB1 IFNG IL10 STAT3
5
Show member pathways
12.67 CXCR4 IFNG IL10 IL17A PRF1
6
Show member pathways
12.44 IFNG IL10 IL17A STAT3
7
Show member pathways
12.41 IFNG IL10 IL17A STAT3 TBX21
8
Show member pathways
12.03 IFNB1 IFNG IL10 STAT3
9
Show member pathways
11.94 IFNB1 IFNG IL10 IL17A
10 11.93 ALB CXCR4 STAT3
11 11.84 IL10 IL17A STAT3
12
Show member pathways
11.83 IFNG STAT3 TBX21
13 11.77 MBP MPZ PMP22
14
Show member pathways
11.76 IFNG IL17A STAT3
15 11.7 CCL5 IFNG IL17A
16
Show member pathways
11.68 IFNG IL10 IL17A STAT3 TBX21
17 11.66 CCL5 CXCR4 IFNG IL10 IL17A STAT3
18 11.6 IFNB1 IFNG IL10
19 11.53 IFNG IL10 IL17A TBX21
20 11.42 CXCR4 IL10 STAT3
21 11.38 CCL5 IL10 STAT3
22 11.18 CXCR4 IFNB1 IFNG IL10 STAT3
23 11.14 IFNG IL17A TBX21
24 11.06 IFNB1 IFNG IL10
25 11.01 CCL5 IFNB1
26
Show member pathways
11.01 IFNG PRF1 STAT3
27 10.9 IFNG PRF1 STAT3 TBX21

GO Terms for Polyradiculoneuropathy

Cellular components related to Polyradiculoneuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.92 ALB MBP MPZ PMP2

Biological processes related to Polyradiculoneuropathy according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.88 IFNG IL10 PMP22 STAT3
2 immune response GO:0006955 9.8 CCL5 IFNG IL10 IL17A MBP
3 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.57 IFNB1 IFNG
4 positive regulation of osteoclast differentiation GO:0045672 9.56 IFNG IL17A
5 positive regulation of innate immune response GO:0045089 9.55 CCL5 IFNB1
6 inflammatory response GO:0006954 9.55 CCL5 CXCR4 IL10 IL17A STAT3
7 positive regulation of interleukin-6 secretion GO:2000778 9.54 IL17A MBP
8 defense response to protozoan GO:0042832 9.52 IFNG IL10
9 dendritic cell chemotaxis GO:0002407 9.51 CCL5 CXCR4
10 myelination GO:0042552 9.5 MBP MPZ PMP22
11 negative regulation of growth of symbiont in host GO:0044130 9.49 IFNG IL10
12 positive regulation of isotype switching to IgG isotypes GO:0048304 9.48 IFNG TBX21
13 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.46 IL10 MBP
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.43 IFNG IL10
15 positive regulation of interleukin-23 production GO:0032747 9.37 IFNG IL17A
16 positive regulation of killing of cells of other organism GO:0051712 9.26 IFNG PRF1
17 response to virus GO:0009615 9.02 CCL5 CXCR4 IFNB1 IFNG TBX21
18 positive regulation of metalloendopeptidase activity GO:1904685 8.96 MBP STAT3

Molecular functions related to Polyradiculoneuropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 fatty acid binding GO:0005504 9.16 ALB PMP2
2 cytokine activity GO:0005125 9.02 CCL5 IFNB1 IFNG IL10 IL17A
3 CCR5 chemokine receptor binding GO:0031730 8.96 CCL5 STAT3

Sources for Polyradiculoneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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