MCID: PLY020
MIFTS: 52

Polyradiculoneuropathy malady

Summaries for Polyradiculoneuropathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Polyradiculoneuropathy describes a condition in which polyneuropathy and polyradiculopathy occur... more...

MalaCards: Polyradiculoneuropathy is related to chronic inflammatory demyelinating polyradiculoneuropathy and neuropathy. An important gene associated with Polyradiculoneuropathy is PMP22 (peripheral myelin protein 22), and among its related pathways are TGF Beta Signaling Pathway and Cytokines and Inflammatory Response. The compounds cycloheximide and pge2 have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and brain, and related mouse phenotypes are reproductive system and nervous system.

Aliases & Classifications for Polyradiculoneuropathy

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

polyradiculoneuropathy 8 44 60


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Disease Ontology8 DOID:4308
SNOMED-CT56 128078004
MeSH34 D011129

Related Diseases for Polyradiculoneuropathy

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17GeneCards, 18GeneDecks
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Diseases related to Polyradiculoneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 241)
idRelated DiseaseScoreTop Affiliating Genes
1chronic inflammatory demyelinating polyradiculoneuropathy31.5MPZ, CCR5, PMP22, IFNB1
2neuropathy30.6PMP22, MBP, MPZ, ALB
3lupus erythematosus30.5CD40LG
4systemic lupus erythematosus30.4CCR5, IFNG, HLA-DRB1, STAT1, IL2, CD40LG
5multiple sclerosis30.3CCL21, CCR5, ALB, IL2, CXCL12, TBX21
6glomerulonephritis30.2CCR5, ALB, CD40LG
7diabetes mellitus30.1ALB, CD40LG, HLA-DRB1, PMP22
8hepatitis30.1IFNB1, STAT1, ALB, HLA-DRB1
9myasthenia gravis30.1MBP, IFNG, CCR5, IL2
10leukemia30.0IFNB1, IFNG, MBP, HLA-DRB1, IL2, CXCL12
11thyroiditis30.0HLA-DRB1
12meningitis30.0ALB, PRF1
13polyneuropathy30.0CD40LG, MPZ, MBP, PMP22
14neuritis30.0MPZ, MBP, PMP2, PMP22
15acute leukemia29.9STAT1, CXCL12, IL2
16hepatitis b29.9ALB, HLA-DRB1, CCR5, IFNG
17guillain-barre syndrome29.9PMP22, CCR5, MPZ, MBP, CD40LG, PMP2
18rabies29.7MPZ
19dermatitis29.7IFNG
20hereditary neuropathy with liability to pressure palsies29.7PMP22
21crohn's disease29.7ALB
22pancreatitis29.7ALB
23hypertension29.7ALB
24pneumonia29.7PRF1
25optic neuritis29.7MPZ, IFNB1, MBP
26viral hepatitis29.7STAT1, HLA-DRB1, IFNB1
27malaria29.7ALB, IFNG, HLA-DRB1
28influenza29.7CCL19, CCR5, IFNB1, IFNG, STAT1
29eosinophilia29.7STAT1, IL2, IFNG
30inflammatory bowel disease29.7STAT1, IFNG, STAT3, CCR5
31psoriasis29.7STAT3, IL2, IFNG, HLA-DRB1
32connective tissue disease29.7IL2, HLA-DRB1, CD40LG, ALB
33sarcoidosis29.7STAT1, HLA-DRB1, CCR5, IFNG, IL2
34graft versus host disease29.7IL2, CCR5, HLA-DRB1, IFNG, CXCL12
35hepatocellular carcinoma29.7IFNB1, STAT3, CCL21, CXCL12, HLA-DRB1, ALB
36encephalomyelitis29.7CCR5, IFNG, IFNB1, MBP, STAT3, MPZ
37cervicitis10.1
38ophthalmoplegia10.1
39membranous glomerulonephritis10.1
40chronic cervicitis10.1
41chronic inflammatory demyelinating polyneuropathy10.1
42lateral sclerosis10.0
43amyotrophic lateral sclerosis10.0
44chronic polyneuropathy10.0
45demyelinating polyneuropathy10.0
46laryngitis10.0
47plasmacytoma10.0
48neurologic diseases10.0
49subacute inflammatory demyelinating polyneuropathy10.0
50polyradiculoneuropathy associated with igg/iga/igm monoclonal gammopathy without known antibodies10.0

Graphical network of the top 20 diseases related to Polyradiculoneuropathy:



Diseases related to polyradiculoneuropathy

Clinical Features for Polyradiculoneuropathy

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Drugs & Therapeutics for Polyradiculoneuropathy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Polyradiculoneuropathy

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Anatomical Context for Polyradiculoneuropathy

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32MalaCards
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MalaCards organs/tissues related to Polyradiculoneuropathy:

32
T cells, Spinal cord, Brain, Tongue, Kidney, Thyroid, Skin, B cells, Heart, Thymus, Lung, Liver, Bone, Pituitary

Animal Models for Polyradiculoneuropathy or affiliated genes

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36MGI
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Publications for Polyradiculoneuropathy

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50PubMed
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Articles related to Polyradiculoneuropathy:

(show top 50)    (show all 436)
idTitleAuthorsYear
1
SjAPgren's syndrome associated chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) treated with autologous and subsequently allogeneic haematopoietic SCT (HSCT). (23503533)
2013
2
Chronic inflammatory demyelinating polyradiculoneuropathy in a patient with Crohn's disease. (23291687)
2013
3
Treatment of chronic inflammatory demyelinating polyradiculoneuropathy. (23931793)
2013
4
Acute polyradiculoneuropathy following honey bee sting. (22566730)
2012
5
Brachial plexus atrophy in chronic inflammatory demyelinating polyradiculoneuropathy. (22622171)
2012
6
Teaching Video NeuroImages: Widespread clinical myokymia in chronic inflammatory demyelinating polyradiculoneuropathy. (21810693)
2011
7
Acute porphyric attack mimicking HIV-associated progressive polyradiculoneuropathy. (21514755)
2011
8
Pulsed high-dose dexamethasone versus standard prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy (PREDICT study): a double-blind, randomised, controlled trial. (20133204)
2010
9
Alemtuzumab: the future of chronic inflammatory demyelinating polyradiculoneuropathy treatment? (20441416)
2010
10
A nationwide retrospective analysis on the effect of immune therapies in patients with chronic inflammatory demyelinating polyradiculoneuropathy. (19863650)
2010
11
Chronic inflammatory demyelinating polyradiculoneuropathy: diagnostic and therapeutic challenges for a treatable condition. (20298964)
2010
12
Chronic Inflammatory Demyelinating Polyradiculoneuropathy. (20393791)
2010
13
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy: the ICE trial. (19496683)
2009
14
Humoral and cellular immune responses to myelin protein peptides in chronic inflammatory demyelinating polyradiculoneuropathy. (19015227)
2009
15
Recommendations on diagnostic strategies for chronic inflammatory demyelinating polyradiculoneuropathy. (18716018)
2008
16
Intravenous immune globulin (10% caprylate-chromatography purified) for the treatment of chronic inflammatory demyelinating polyradiculoneuropathy (ICE study): a randomised placebo-controlled trial. (18178525)
2008
17
Spinal nerve root hypertrophy on MRI: clinical significance in the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy. (19043253)
2008
18
Pain as the presenting symptom of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). (17286985)
2007
19
Pathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy. (16519780)
2006
20
T cell reactivity to P0, P2, PMP-22, and myelin basic protein in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. (16170091)
2005
21
Acute polyradiculoneuropathy occurring after hymenoptera stings: a clinical case study. (15888260)
2005
22
Cyclosporine in chronic inflammatory demyelinating polyradiculoneuropathy. (16243226)
2005
23
Chronic inflammatory demyelinating polyradiculoneuropathy: two cases with cervical spinal cord compression. (16172720)
2005
24
Recurrent polyradiculoneuropathy and PMP22 defects. (16323394)
2005
25
129th ENMC International Workshop: Clinical Trials for Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy, 27th October 2004, Schiphol airport, The Netherlands. (15792873)
2005
26
Differentiating paralytic rabies from post antirabies vaccine polyradiculoneuropathy. (15269494)
2004
27
Chronic inflammatory demyelinating polyradiculoneuropathy. (15210544)
2004
28
Aberrated levels of cerebrospinal fluid chemokines in Guillain-BarrAc syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. (12959218)
2003
29
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy. (12076423)
2002
30
Chronic inflammatory demyelinating polyradiculoneuropathy: a study of proposed electrodiagnostic and histologic criteria. (11115240)
2000
31
Inflammatory demyelinating polyradiculoneuropathy associated with interstitial lung disease. (10870663)
2000
32
Chronic inflammatory demyelinating polyradiculoneuropathy: a prevalence study in south east England. (10209187)
1999
33
Electrophysiologic assessment of acute polyradiculoneuropathy in dogs: comparison with Guillain-BarrAc syndrome in people. (9686390)
1998
34
A case of myasthenia gravis in childhood associated with chronic inflammatory demyelinating polyradiculoneuropathy. (9638666)
1998
35
Severe sensorimotor polyradiculoneuropathy after ingestion of ethylene glycol. (9285476)
1997
36
Ophthalmoplegia in an adult with chronic inflammatory demyelinating polyradiculoneuropathy. (21314387)
1997
37
Chronic inflammatory demyelinating polyradiculoneuropathy. (7921585)
1994
38
Hashimoto's thyroiditis associated with acquired idiopathic demyelinating polyradiculoneuropathy. (1924068)
1991
39
Chronic inflammatory demyelinating polyradiculoneuropathy. A clinical, electrophysiological and biopsy study. (1652403)
1991
40
Early relapse of acute inflammatory polyradiculoneuropathy after successful treatment with plasma exchange. (3389077)
1988
41
Plasmapheresis in the treatment of acute relapsing inflammatory demyelinating polyradiculoneuropathy associated with human immunodeficiency virus infection: a case report. (3220816)
1988
42
Fulminant leukemic polyradiculoneuropathy in a case of B-cell prolymphocytic leukemia. A clinicopathologic report. (3040217)
1987
43
Cytomegalovirus polyradiculoneuropathy in acquired immune deficiency syndrome. (3031543)
1987
44
Acute and chronic demyelinating inflammatory polyradiculoneuropathy. Association with autoimmune diseases and lymphocyte response to human neuritogenic protein. (2424413)
1986
45
Acute polyradiculoneuropathy complicating systemic lupus erythematosus. (3714625)
1986
46
Ocular myasthenia gravis and chronic inflammatory polyradiculoneuropathy. (3463893)
1986
47
Antibody to glycolipid in a patient with IgM paraproteinemia and polyradiculoneuropathy. (2413705)
1985
48
Locked-in syndrome in acute inflammatory polyradiculoneuropathy. (6723715)
1984
49
Treatment of chronic relapsing inflammatory polyradiculoneuropathy by plasma exchange. (534424)
1979
50
POLYRADICULONEUROPATHY (GUILLAIN-BARR'E SYNDROME) TREATED WITH 6-MERCAPTOPURINE. (14255243)
1965

Genetic Variations for Polyradiculoneuropathy

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Expression for genes affiliated with Polyradiculoneuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyradiculoneuropathy

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Pathways for genes affiliated with Polyradiculoneuropathy

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37NCBI BioSystems Database, 53Reactome, 29KEGG, 4Cell Signaling Technology, 12EMD Millipore, 59Tocris Bioscience, 51QIAGEN, 52R&D Systems
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Pathways related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

(show all 46)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3STAT1
210.2HLA-DRB1
310.0STAT1, IFNG
49.8HLA-DRB1, IFNB1
5
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9.7CXCL12, STAT1, STAT3
6
Development Thrombopoetin signaling via JAK-STAT pathway
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9.7IFNG, STAT3, STAT1
7
Immune response IFN gamma signaling pathway
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9.7IFNG, STAT3, STAT1
8
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9.6IL2, STAT1, STAT3
99.6IL2, CD40LG, IFNG
109.6STAT1, IFNB1, IFNG
119.6IFNG, IFNB1, STAT1
129.5SH2D2A, STAT1, STAT3
139.5IFNG, PRF1, IL2
14
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9.5CCR5, IFNG, STAT3, STAT1
159.4HLA-DRB1, STAT3, STAT1, CXCL12
169.4IFNG, IFNB1, IL2
179.4IFNG, STAT1, TBX21, IL2
18
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9.4IL2, CD40LG, TBX21, IFNG
19
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9.4CCR5, IFNG, CD40LG, IL2
20
Development PDGF signaling via STATs and NF-kB
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9.4IL2, STAT1, STAT3, IFNG
21
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9.4IL2, STAT1, STAT3, IFNG
229.3IL2, STAT1, STAT3, HLA-DRB1
239.3PMP22, MBP, MPZ
24
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.2MBP, STAT3, STAT1
25
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9.1IFNG, STAT3, STAT1, TBX21, IL2
26
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9.1IFNG, HLA-DRB1, PRF1, CD40LG, CXCL12
27
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9.1IFNG, HLA-DRB1, STAT3, STAT1, IL2
28
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9.0CCR5, HLA-DRB1, STAT3, STAT1, TBX21, CD40LG
29
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9.0IL2, STAT1, STAT3, IFNB1, IFNG
309.0IFNG, IFNB1, STAT3, STAT1, IL2
318.9CCL19, CCL21, CD40LG, CXCL12
32
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8.8CCL19, CCL21, CCR5, CXCL12
338.8CCL19, CCL21, CCR5, CXCL12
348.7IL2, TBX21, PRF1, STAT3, HLA-DRB1, IFNG
35
Apoptosis and survival Lymphotoxin-beta receptor signaling
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8.7IL2, CXCL12, CCL21, CCL19
36
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8.7IFNG, IFNB1, PRF1, SH2D2A, IL2
37
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8.6IFNG, IFNB1, HLA-DRB1, STAT3, STAT1, IL2
38
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8.6IFNG, IFNB1, HLA-DRB1, STAT3, STAT1, IL2
39
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8.6CCR5, IFNG, HLA-DRB1, STAT3, STAT1, TBX21
40
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8.6CCL19, CCL21, IFNB1, IL2
41
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8.4CCL19, CCL21, CCR5, IFNB1, CXCL12
42
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8.4IFNG, IFNB1, HLA-DRB1, STAT3, STAT1, CD40LG
43
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8.3CCL19, CCL21, CCR5, STAT3, STAT1, CXCL12
44
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8.3CCL19, CCL21, CCR5, STAT3, STAT1, CXCL12
45
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8.0CCL19, CCL21, CCR5, STAT3, STAT1, CXCL12
46
Hide members
8.0CCL19, CCL21, CCR5, STAT3, STAT1, CXCL12

Compounds for genes affiliated with Polyradiculoneuropathy

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.0CXCL12, STAT1, IFNB1
2pge24410.0IL2, CCL19
3gold sodium thiomalate449.8IFNG, HLA-DRB1, IL2
4mdms449.8CXCL12, STAT1, CCR5
5serine449.7PMP22, CCR5, STAT3, STAT1, MPZ
6retinyl palmitate44 2410.7IFNB1, STAT3, IL2
7heparin44 28 11 2412.7CXCL12, CD40LG, IFNB1, CCR5
8dexamethasone44 49 28 1112.7CXCL12, CD40LG, STAT3, IFNB1
9indomethacin44 59 28 1112.7MBP, IFNB1
10rituximab44 49 1111.7STAT3, CD40LG, CXCL12, IL2
11auranofin44 59 28 1112.7ALB, IL2, IFNG
12aspartate449.6PMP22, CCR5, MPZ, CD40LG, ALB
13mycophenolate mofetil44 49 1111.6IFNG, CD40LG, IL2, ALB
142,5-oligoadenylate449.6IFNG, IFNB1, STAT1, IL2
15il 10449.5CCR5, IFNG, IFNB1, IL2
16neopterin449.5IL2, CD40LG, IFNB1, IFNG
17galactosylceramide449.5CXCL12, MBP, CCR5
18thalidomide44 49 59 1112.5IFNG, STAT3, CD40LG, IL2
19sulfamethoxazole44 49 1111.4CD40LG, IL2, ALB
20glutamate449.4CD40LG, MBP
21teck449.4CCL19, CCL21, CXCL12
22polyinosinic-polycytidylic acid449.4IFNG, IFNB1, STAT3, STAT1, IL2
235-aza-2deoxycytidine449.4IFNG, IFNB1, STAT3, STAT1, CXCL12
24ccl444 2810.4CCL21, CCR5, IFNB1, CXCL12
25ribavirin44 49 1111.3CCR5, IFNG, STAT3, STAT1, CD40LG, IL2
26valsartan44 59 28 1112.3STAT3, STAT1, ALB
27mezerein449.3MBP, IFNB1, IFNG
28vegf449.3IFNB1, STAT3, STAT1, SH2D2A, CXCL12
29ganglioside449.2CD40LG, MPZ, MBP, PMP22
30zidovudine44 1110.2CCR5, IFNB1, CXCL12, IL2, ALB
31larc449.2CCL19, CCL21, CCR5, CXCL12
32herbimycin a44 5910.2IFNG, IFNB1, STAT1, CD40LG, CXCL12, IL2
33ifn-alpha449.1IFNG, IFNB1, STAT3, STAT1, CXCL12, IL2
345fluorouracil449.1IFNG, IFNB1, STAT3, CXCL12, IL2
35rapamycin449.0CCR5, IFNG, STAT3, STAT1, CD40LG, CXCL12
36cyclosporin a44 28 5911.0IFNG, MBP, STAT3, STAT1, CD40LG
37rantes448.9IL2, IFNG, IFNB1, STAT3, STAT1, CD40LG
38genistein44 28 59 2 11 2413.9IFNG, IFNB1, STAT3, STAT1, CD40LG, CXCL12
39actinomycin d448.7CCR5, IFNG, IFNB1, STAT3, STAT1, CD40LG
40tarc448.6CCL19, CCL21, CCR5, IFNG, IFNB1, CXCL12
41ccl344 289.6CCL19, CCL21, CCR5, IFNG, IFNB1, CXCL12
42cholesterol44 28 11 2411.6CCR5, IFNB1, STAT3, STAT1, MPZ, PRF1
43glatiramer acetate44 119.6IFNG, IFNB1, MBP, HLA-DRB1, MPZ, IL2
44ivig448.5CCR5, IFNG, IFNB1, MBP, CD40LG, ALB
45cisplatin44 49 59 1111.3IFNB1, MBP, STAT3, STAT1, CD40LG, IL2
46thymidine44 249.2IFNG, IFNB1, MBP, STAT3, CXCL12, IL2
47retinoic acid44 249.1PMP22, CCR5, IFNG, IFNB1, MBP, STAT3
48arginine447.9PMP22, CCR5, IFNG, MBP, HLA-DRB1, STAT3
49cysteine447.6PMP22, CCR5, IFNG, IFNB1, MBP, STAT3
50tyrosine447.3CCR5, IFNB1, MBP, HLA-DRB1, STAT3, STAT1

GO Terms for genes affiliated with Polyradiculoneuropathy

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16Gene Ontology
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Cellular components related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:0432189.5MBP, PMP22
2external side of plasma membraneGO:0098979.1CCR5, IFNG, HLA-DRB1, CD40LG, CXCL12
3extracellular spaceGO:0056157.4ALB, CCL19, CCL21, IFNG, IFNB1, CD40LG
4extracellular regionGO:0055767.1CCL19, CCL21, IFNG, IFNB1, PRF1, CXCL12

Biological processes related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of metanephric nephron tubule epithelial cell differentiationGO:07230810.3IFNG, STAT1
2negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:00334010.3IFNG, STAT1
3positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:03314110.1IFNG, IFNB1
4positive regulation of isotype switching to IgG isotypesGO:04830410.0IFNG, TBX21, IL2
5interferon-gamma-mediated signaling pathwayGO:0603339.8STAT1, HLA-DRB1, IFNG
6positive regulation of interleukin-12 productionGO:0327359.7CD40LG, IFNG, CCL19
7positive regulation of glycoprotein biosynthetic processGO:0105609.6CCL19, CCL21
8immunological synapse formationGO:0017719.6CCL21, CCL19
9establishment of T cell polarityGO:0017689.6CCL19, CCL21
10response to prostaglandin E stimulusGO:0346959.6CCL21, CCL19
11B cell proliferationGO:0421009.5IFNB1, CD40LG
12positive regulation of dendritic cell antigen processing and presentationGO:0026069.5CCL21, CCL19
13defense response to virusGO:0516079.5PRF1, STAT1, IFNB1, IFNG
14negative regulation of leukocyte apoptotic processGO:20001079.4CCL19, CCL21, CXCL12
15positive regulation of chemotaxisGO:0509219.4CCL21, CCL19
16dendritic cell chemotaxisGO:0024079.4CCR5, CCL21, CCL19
17positive regulation of cell motilityGO:20001479.3CCL21, CCL19
18cytokine-mediated signaling pathwayGO:0192219.3IFNG, IFNB1, HLA-DRB1, STAT3, STAT1
19positive regulation of receptor-mediated endocytosisGO:0482609.2CCL19, CCL21
20membrane organizationGO:0610249.2MBP, PMP2
21T cell costimulationGO:0312959.2CCL19, CCL21, HLA-DRB1
22response to virusGO:0096159.1CCL19, IFNG, IFNB1, TBX21, CXCL12
23inflammatory responseGO:0069548.8CD40LG, CCR5, CCL21, CCL19
24immune responseGO:0069557.7IL2, CXCL12, HLA-DRB1, MBP, CCR5, CCL21

Molecular functions related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR7 chemokine receptor bindingGO:0317329.2CCL21, CCL19
2chemokine activityGO:0080099.1CXCL12, CCL21, CCL19
3cytokine activityGO:0051258.9IL2, CD40LG, IFNB1, IFNG

Products for genes affiliated with Polyradiculoneuropathy

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Sources for Polyradiculoneuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet