MCID: PLY020
MIFTS: 55

Polyradiculoneuropathy malady

Neuronal diseases category

Summaries for Polyradiculoneuropathy

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66Wikipedia, 34MalaCards
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Wikipedia:66 Polyradiculoneuropathy describes a condition in which polyneuropathy and polyradiculopathy occur... more...

MalaCards: Polyradiculoneuropathy is related to chronic inflammatory demyelinating polyradiculoneuropathy and neuropathy. An important gene associated with Polyradiculoneuropathy is PMP22 (peripheral myelin protein 22), and among its related pathways are Interferon Pathway and Type II interferon signaling (IFNG). The compounds gamma globulin and mdms have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord, and related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Polyradiculoneuropathy

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9Disease Ontology, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

polyradiculoneuropathy 9 46 63


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Disease Ontology9 DOID:4308
SNOMED-CT59 128078004
MeSH36 D011129

Related Diseases for Polyradiculoneuropathy

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18GeneCards, 19GeneDecks
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Diseases related to Polyradiculoneuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1chronic inflammatory demyelinating polyradiculoneuropathy31.7IFNB1, CCR5, PMP22, MPZ
2neuropathy30.7MPZ, MBP, ALB, PMP22
3systemic lupus erythematosus30.4CD40LG, HLA-DRB1, IL2, IFNG, STAT1, IFNB1
4glomerulonephritis30.3CD40LG, CCR5, ALB
5hepatitis30.3CD40LG, STAT1, IFNB1, CXCL12
6membranous glomerulonephritis30.2ALB, CCR5
7diabetes mellitus30.2HLA-DRB1, CD40LG, ALB, PMP22
8myasthenia gravis30.2IL2, MBP, CCR5, IFNG
9polyneuropathy30.1PMP22, CD40LG, MBP, MPZ
10neuritis30.1MPZ, MBP, PMP22, PMP2
11hepatitis b30.0CCR5, IFNG, ALB, HLA-DRB1
12hereditary neuropathy with liability to pressure palsies30.0PMP22
13multiple sclerosis30.0STAT1, CXCL12, MPZ, SH2D2A, HLA-DRB1, IFNB1
14hereditary neuropathies30.0MPZ, PMP22
15guillain-barre syndrome30.0PMP22, CD40LG, MBP, PMP2, MPZ, CCR5
16viral hepatitis29.9IFNB1, STAT1, HLA-DRB1
17leukemia29.9HLA-DRB1, IFNB1, STAT1, STAT3, CXCL12, IL2
18optic neuritis29.9IFNB1, MPZ, MBP
19eosinophilia29.9IFNG, IL2, STAT1
20malaria29.9ALB, IFNG, HLA-DRB1
21inflammatory bowel disease29.8STAT3, CCR5, IFNG, STAT1
22influenza29.8IFNB1, CCL19, CCR5, STAT1, IFNG
23type 1 diabetes mellitus29.8HLA-DRB1, CCR5, ALB
24connective tissue disease29.8CD40LG, HLA-DRB1, IL2, ALB
25psoriasis29.8IL2, HLA-DRB1, STAT3, IFNG
26sarcoidosis29.8IL2, HLA-DRB1, STAT1, IFNG, CCR5
27graft versus host disease29.8IL2, HLA-DRB1, CXCL12, CCR5, IFNG
28hepatocellular carcinoma29.7ALB, CCL19, HLA-DRB1, CCL21, CXCL12, STAT3
29encephalomyelitis29.7MPZ, STAT3, IFNG, IL2, MBP, CCR5
30lupus erythematosus10.4
31cervicitis10.2
32ophthalmoplegia10.2
33chronic inflammatory demyelinating polyneuropathy10.2
34multifocal motor neuropathy10.2
35periapical granuloma10.1CCR5
36charcot-marie-tooth neuropathy type 1a10.1PMP22, MPZ
37motor peripheral neuropathy10.1PMP22, MPZ
38acute disseminated encephalomyelitis10.1MBP
39charcot-marie-tooth disease type 4e10.1MPZ, PMP22
40aplastic anemia10.1IFNG
41inherited peripheral neuropathy10.1MPZ, PMP22
42brachial plexus neuropathy10.1MPZ, PMP22
43tooth disease10.1MPZ, PMP22
44hemorrhagic fever10.1CD40LG
45primary immunodeficiency disease10.1CD40LG
46charcot-marie-tooth disease type 310.1PMP22, MPZ
47syphilis10.1CCR5
48charcot-marie-tooth neuropathy type 110.1MPZ, PMP22
49myelitis10.1MBP
50diabetic neuropathy10.1PMP22, MPZ

Graphical network of the top 20 diseases related to Polyradiculoneuropathy:



Diseases related to polyradiculoneuropathy

Symptoms for Polyradiculoneuropathy

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Drugs & Therapeutics for Polyradiculoneuropathy

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Polyradiculoneuropathy

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Anatomical Context for Polyradiculoneuropathy

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34MalaCards
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MalaCards organs/tissues related to Polyradiculoneuropathy:

34
T cells, Brain, Spinal cord, Tongue, Kidney, Thyroid, Bone, B cells, Skin, Lung, Liver, Heart, Thymus, Pituitary

Animal Models for Polyradiculoneuropathy or affiliated genes

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38MGI
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Publications for Polyradiculoneuropathy

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53PubMed
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Articles related to Polyradiculoneuropathy:

(show top 50)    (show all 433)
idTitleAuthorsYear
1
SjAPgren's syndrome associated chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) treated with autologous and subsequently allogeneic haematopoietic SCT (HSCT). (23503533)
2013
2
Chronic inflammatory demyelinating polyradiculoneuropathy in a patient with Crohn's disease. (23291687)
2013
3
Chronic inflammatory demyelinating polyradiculoneuropathy in a patient with systemic lupus erythematosus and good outcome with rituximab treatment. (21922339)
2012
4
CD8+ T-cell immunity in chronic inflammatory demyelinating polyradiculoneuropathy. (22238416)
2012
5
Chronic inflammatory demyelynating polyradiculoneuropathy in childhood and response to IVIg. (24391437)
2011
6
Brachial and lumbar plexuses in chronic inflammatory demyelinating polyradiculoneuropathy: MRI assessment including apparent diffusion coefficient. (20405114)
2011
7
Pulsed high-dose dexamethasone versus standard prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy (PREDICT study): a double-blind, randomised, controlled trial. (20133204)
2010
8
Understanding the consequences of chronic inflammatory demyelinating polyradiculoneuropathy from impairments to activity and participation restrictions and reduced quality of life: the ICE study. (21040143)
2010
9
A case of acute polyradiculoneuropathy, drug-induced hypersensitivity, and HHV-6 infection. (19273829)
2009
10
Acute polyradiculoneuropathy following wasp sting. (19934578)
2009
11
Intravenous immunoglobulin for chronic inflammatory demyelinating polyradiculoneuropathy. (19160200)
2009
12
Chronic inflammatory demyelinating polyradiculoneuropathy: a role for haematopoietic stem cell transplantation? (18958756)
2008
13
Rituximab therapy in chronic inflammatory demyelinating polyradiculoneuropathy with anti-SGPG IgM antibody. (16814550)
2006
14
European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. (16643309)
2006
15
Chronic inflammatory demyelinating polyradiculoneuropathy: new views and guidelines. (16221282)
2005
16
Antibodies to peripheral nerve myelin proteins in chronic inflammatory demyelinating polyradiculoneuropathy. (15958128)
2005
17
T cell reactivity to P0, P2, PMP-22, and myelin basic protein in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. (16170091)
2005
18
Chronic inflammatory demyelinating polyradiculoneuropathy: MRI study of brain and spinal cord. (15753438)
2005
19
Chronic inflammatory demyelinating polyradiculoneuropathy in patients with liver transplantation. (15372442)
2004
20
Diffuse spinal and intercostal nerve involvement in chronic inflammatory demyelinating polyradiculoneuropathy: MRI findings. (16440223)
2003
21
Chronic inflammatory demyelinating polyradiculoneuropathy in diabetic patients. (12661048)
2003
22
Waldenstrom's Macroglobulinaemia Presenting as Demyelinating Polyradiculoneuropathy. (24326654)
2002
23
Proposed revised electrophysiological criteria for chronic inflammatory demyelinating polyradiculoneuropathy. (11754181)
2002
24
Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy. (11869620)
2002
25
Randomized controlled trial of IVIg in untreated chronic inflammatory demyelinating polyradiculoneuropathy. (11222785)
2001
26
Inflammatory polyradiculoneuropathy with spinal cord involvement and lethal [correction of letal] outcome after hepatitis B vaccination. (11412876)
2001
27
Chronic inflammatory demyelinating polyradiculoneuropathy with histologically proven optic neuritis. (11484826)
2001
28
Ataxic form of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). (10809947)
2000
29
Chronic inflammatory demyelinating polyradiculoneuropathy and severe peripheral oedema: a renal explanation. (10844803)
2000
30
Chronic inflammatory demyelinating polyradiculoneuropathy: a prevalence study in south east England. (10209187)
1999
31
Acute inflammatory demyelinating polyradiculoneuropathy associated with hyperIgEemia and atopic dermatitis. (9562273)
1998
32
Chronic inflammatory demyelinating polyradiculoneuropathy: superiority of protein A immunoadsorption over plasma exchange treatment. (10178691)
1998
33
Anti-GQ1b and anti-GT1a IgG antibodies in a patient with acute demyelinating polyradiculoneuropathy without ophthalmoplegia. (9328270)
1997
34
A novel trial design to study the effect of intravenous immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy. (8936360)
1996
35
Acute inflammatory demyelinating polyradiculoneuropathy following antirabies vaccine. (9251443)
1996
36
Long-term treatment of chronic inflammatory demyelinating polyradiculoneuropathy with plasma exchange or intravenous immunoglobulin. (7633875)
1995
37
Glomerulonephritis associated with inflammatory demyelinating polyradiculoneuropathy: a case report and review of the literature. (8502319)
1993
38
Nerve root enhancement with MRI in inflammatory demyelinating polyradiculoneuropathy. (8451012)
1993
39
Prognosis in long-term immunosuppressive treatment of refractory chronic inflammatory demyelinating polyradiculoneuropathy. (1738011)
1992
40
Chronic inflammatory demyelinating polyradiculoneuropathy associated with Evans' syndrome. (1341469)
1992
41
Chronic inflammatory demyelinating polyradiculoneuropathy: comparison of patients with and without an associated monoclonal gammopathy. (1603342)
1992
42
Acquired factor VIII deficiency and polyradiculoneuropathy. (1901137)
1991
43
Evoked potentials suggest cranial nerves and CNS involvement in chronic relapsing polyradiculoneuropathy. (2731562)
1989
44
Polyradiculoneuropathy in transfusion-associated AIDS and dorsal root pathology. (2928972)
1989
45
Class and IgG subclass distribution of antibodies against peripheral nerve myelin in sera from patients with inflammatory demyelinating polyradiculoneuropathy. (2464267)
1988
46
Absence of antimyelin antibodies and serum demyelinating factors in most patients with chronic inflammatory demyelinating polyradiculoneuropathy. (3267485)
1988
47
Fulminant leukemic polyradiculoneuropathy in a case of B-cell prolymphocytic leukemia. A clinicopathologic report. (3040217)
1987
48
Idiopathic inflammatory polyradiculoneuropathy: evaluation of clinical and laboratory data and therapeutic considerations. (6862843)
1983
49
British multicentre trial of plasma exchange in acute inflammatory polyradiculoneuropathy (AIP). (6757939)
1982
50
Polyradiculoneuropathy in Addison's disease. Case report and review of literature. (558557)
1977

Variations for Polyradiculoneuropathy

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Expression for genes affiliated with Polyradiculoneuropathy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Polyradiculoneuropathy

Search GEO for disease gene expression data for Polyradiculoneuropathy.

Pathways for genes affiliated with Polyradiculoneuropathy

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 61Thomson Reuters, 55R&D Systems, 5Cell Signaling Technology, 31KEGG, 62Tocris Bioscience, 56Reactome
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Pathways related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7STAT1, IFNG, IFNB1
29.7IFNG, STAT1, IFNB1
3
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.7STAT1, IFNB1, IFNG
4
Show member pathways
9.6IFNG, STAT3, STAT1
5
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.6STAT3, IFNG, STAT1
69.6STAT1, IFNG, STAT3
7
Show member pathways
IFN-gamma pathway39
9.6STAT1, STAT3, IFNG
89.6HLA-DRB1, CXCL12, IFNG
9
Show member pathways
9.5IL2, STAT1, STAT3
109.5IL2, IFNG, IFNB1
119.5CD40LG, IFNG, IL2
129.5STAT1, SH2D2A, STAT3
139.5PRF1, IFNG, STAT3
149.4HLA-DRB1, STAT1, IFNB1, IFNG
159.4STAT1, CXCL12, HLA-DRB1, STAT3
16
Show member pathways
Ras signaling in the CD4+ TCR pathway39
9.4IFNG, PRF1, IL2
17
Show member pathways
9.4CCR5, STAT1, STAT3, IFNG
189.3IL2, TBX21, IFNG, STAT1
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.3CD40LG, TBX21, IFNG, IL2
20
Show member pathways
9.3CXCL12, STAT1, IL2, STAT3
219.3MPZ, MBP, PMP22
22
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.3STAT1, STAT3, HLA-DRB1, IL2
239.3IFNB1, IL2, HLA-DRB1, IFNG
24
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.2CD40LG, IL2, IFNG, CCR5
25
Show member pathways
IL-2 Signaling pathway39
9.2IL2, IFNG, STAT1, STAT3
26
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.2STAT1, IFNG, STAT3, IL2
27
Show member pathways
Immune response CD16 signaling in NK cells61
9.2IFNB1, IL2, PRF1, IFNG
28
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.1STAT3, STAT1, MBP
29
Show member pathways
Type III interferon signaling39
9.0IFNB1, STAT3, IFNG, IL2, STAT1
30
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.0IFNB1, STAT3, STAT1, IFNG, IL2
31
Show member pathways
9.0IL2, STAT3, CXCL12, HLA-DRB1, STAT1
32
Show member pathways
IL27-mediated signaling events39
9.0IL2, STAT3, TBX21, STAT1, IFNG
33
Show member pathways
8.9IL2, IFNG, HLA-DRB1, STAT3, STAT1
348.9IFNG, IL2, MBP
358.8CCL21, CD40LG, CCL19, CXCL12
36
Show member pathways
8.8CXCL12, CCR5, CCL19, CCL21
37
Show member pathways
8.7IFNG, STAT1, IL2, IFNB1, STAT3, HLA-DRB1
38
Show member pathways
8.7STAT3, HLA-DRB1, STAT1, IFNB1, IFNG, IL2
39
Show member pathways
Apoptosis and survival Lymphotoxin beta receptor signaling61
8.7IL2, CXCL12, CCL21, CCL19
40
Show member pathways
8.6CXCL12, CD40LG, HLA-DRB1, IL2, IFNG, PRF1
418.6PRF1, TBX21, STAT3, IFNG, HLA-DRB1, IL2
42
Show member pathways
Immune response IL 12 induced IFN gamma production61
8.4TBX21, IL2, IFNG, CCR5, STAT1, STAT3
43
Show member pathways
8.4IL2, CCR5, CXCL12, CCL19, CCL21
44
Show member pathways
8.3CXCL12, CCL21, STAT3, CCL19, STAT1, CCR5
45
Show member pathways
8.3STAT3, CCL21, CXCL12, STAT1, CCR5, CCL19
46
Show member pathways
8.2HLA-DRB1, STAT3, STAT1, CD40LG, TBX21, IL2
47
Show member pathways
7.9CCL19, CXCL12, STAT3, STAT1, IL2, CCR5
48
Show member pathways
7.9STAT3, CXCL12, CCL19, STAT1, IL2, CCL21
49
Show member pathways
7.6STAT1, CXCL12, CCL19, IL2, IFNG, CCL21
50
Show member pathways
7.3CD40LG, IL2, IFNG, CCL19, CCR5, STAT3

Compounds for genes affiliated with Polyradiculoneuropathy

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Sources:
46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1gamma globulin469.9ALB, IFNG, CD40LG
2mdms469.7CCR5, STAT1, CXCL12
32,5-oligoadenylate469.7IFNB1, IFNG, STAT1, IL2
4retinyl palmitate46 2510.6IL2, IFNB1, STAT3
5il 10469.6IFNG, CCR5, IL2, IFNB1
6neopterin469.6IFNG, CD40LG, IFNB1, IL2
7rituximab46 52 1211.5IL2, STAT3, CXCL12, CD40LG
8mycophenolate mofetil46 52 1211.5ALB, IFNG, IL2, CD40LG
95-aza-2deoxycytidine469.5CXCL12, STAT1, IFNB1, IFNG, STAT3
10gold sodium thiomalate469.5IL2, HLA-DRB1, IFNG
11galactosylceramide469.4MBP, CCR5, CXCL12
12ccl446 3010.4IFNB1, CCL21, CCR5, CXCL12
13polyinosinic-polycytidylic acid469.4IFNG, IFNB1, IL2, STAT3, STAT1
14mezerein469.4IFNB1, IFNG, MBP
15zidovudine46 52 1211.4IL2, ALB, CXCL12, CCR5, IFNB1
16teck469.3CCL19, CCL21, CXCL12
175fluorouracil469.2IL2, IFNG, CXCL12, IFNB1, STAT3
18herbimycin a46 6210.2IFNB1, STAT1, IFNG, CD40LG, CXCL12, IL2
19larc469.2CCR5, CCL21, CCL19, CXCL12
20ifn-alpha469.2IFNB1, IL2, STAT1, STAT3, IFNG, CXCL12
21ganglioside469.1MPZ, CD40LG, MBP, PMP22
22thalidomide46 52 62 1212.1STAT3, IFNG, IL2, CD40LG
23ribavirin46 52 1210.9CCR5, STAT1, STAT3, IFNG, IL2, CD40LG
24genistein46 30 62 3 25 1213.9IFNG, IFNB1, STAT3, CD40LG, IL2, STAT1
25sb 20358046 629.9IFNB1, STAT1, STAT3, CXCL12, IFNG
26rapamycin468.9STAT3, CD40LG, IL2, IFNG, CCR5, CXCL12
27tarc468.7CCL19, IFNG, IFNB1, CCL21, CCR5, CXCL12
28ccl346 309.7CCL21, CCL19, IFNG, CXCL12, IFNB1, CCR5
29ivig468.7CCR5, IFNB1, CD40LG, MBP, ALB, IFNG
30cholesterol46 30 25 1211.7ALB, CCR5, MPZ, PRF1, CXCL12, IFNB1
31glatiramer acetate46 129.7MPZ, IFNB1, HLA-DRB1, IFNG, IL2, MBP
32actinomycin d468.7IL2, IFNG, IFNB1, CCR5, STAT1, STAT3
33dexamethasone46 52 30 1211.6IFNG, IFNB1, IL2, CCR5, STAT1, STAT3
34cisplatin46 52 62 1211.4CD40LG, MBP, STAT3, STAT1, IL2, IFNB1
35vegf468.4STAT1, CXCL12, IFNB1, IL2, CD40LG, SH2D2A
36glutamate468.4CXCL12, MPZ, HLA-DRB1, IFNB1, MBP, CCR5
37heparin46 30 25 1211.4ALB, MBP, IFNB1, CCR5, STAT3, CXCL12
38thymidine46 259.4IFNB1, CXCL12, IFNG, IL2, STAT3, MBP
39indomethacin46 30 62 1211.3IFNG, IL2, CD40LG, MBP, ALB, STAT1
40aspartate468.3IFNB1, CCR5, STAT3, PMP22, MPZ, MBP
41cyclosporin a46 30 6210.3CD40LG, IL2, IFNG, CCR5, STAT1, STAT3
42retinoic acid46 259.2PMP22, STAT3, STAT1, CCR5, IFNB1, IFNG
43alanine468.2CD40LG, HLA-DRB1, STAT3, MBP, CCR5, IFNB1
44cycloheximide468.0STAT1, MBP, IL2, IFNG, STAT3, PRF1
45arginine467.8STAT3, HLA-DRB1, CD40LG, MBP, IFNG, CCR5
46cysteine467.8IFNG, IFNB1, STAT1, ALB, MBP, CD40LG
47rantes467.5CCR5, IFNB1, IFNG, CD40LG, IL2, CCL19
48pge2467.5STAT3, CD40LG, IL2, IFNG, IFNB1, CCL21
49tyrosine467.4STAT3, CCR5, CXCL12, STAT1, MPZ, SH2D2A
50serine467.4CXCL12, PRF1, MPZ, STAT3, CD40LG, MBP

GO Terms for genes affiliated with Polyradiculoneuropathy

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17Gene Ontology
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Cellular components related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1compact myelinGO:0432189.5MBP, PMP22
2external side of plasma membraneGO:0098979.0CD40LG, IFNG, CCR5, CXCL12, HLA-DRB1
3extracellular spaceGO:0056157.6IFNG, CCL21, IL2, ALB, CD40LG, CCL19
4extracellular regionGO:0055767.1ALB, IL2, IFNG, IFNB1, CCL21, CCL19

Biological processes related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of metanephric nephron tubule epithelial cell differentiationGO:07230810.3STAT1, IFNG
2negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:00334010.3STAT1, IFNG
3positive regulation of monocyte chemotaxisGO:09002610.2CXCL12, CCR5
4regulation of interferon-gamma-mediated signaling pathwayGO:06033410.0IFNG, STAT1
5positive regulation of peptidyl-serine phosphorylation of STAT proteinGO:0331419.9IFNB1, IFNG
6interferon-gamma-mediated signaling pathwayGO:0603339.9HLA-DRB1, STAT1, IFNG
7positive regulation of isotype switching to IgG isotypesGO:0483049.9TBX21, IFNG, IL2
8natural killer cell activationGO:0301019.8IL2, IFNB1
9positive regulation of interleukin-12 productionGO:0327359.7CCL19, IFNG, CD40LG
10defense response to virusGO:0516079.7PRF1, IFNB1, IFNG, STAT1
11cell surface receptor signaling pathwayGO:0071669.7IFNG, IFNB1, CCR5
12positive regulation of glycoprotein biosynthetic processGO:0105609.7CCL19, CCL21
13immunological synapse formationGO:0017719.7CCL21, CCL19
14establishment of T cell polarityGO:0017689.6CCL21, CCL19
15response to prostaglandin EGO:0346959.6CCL19, CCL21
16positive regulation of dendritic cell antigen processing and presentationGO:0026069.6CCL19, CCL21
17positive regulation of cell motilityGO:20001479.6CCL19, CCL21
18positive regulation of chemotaxisGO:0509219.5CCL21, CCL19
19cytokine-mediated signaling pathwayGO:0192219.5HLA-DRB1, STAT1, IFNG, IFNB1, STAT3
20positive regulation of receptor-mediated endocytosisGO:0482609.5CCL21, CCL19
21negative regulation of leukocyte apoptotic processGO:20001079.5CCL21, CCL19, CXCL12
22dendritic cell chemotaxisGO:0024079.4CCL21, CCL19, CCR5
23positive regulation of neutrophil chemotaxisGO:0900239.4CCL19, CCL21
24positive regulation of interleukin-1 beta secretionGO:0507189.3CCL19, IFNG
25response to virusGO:0096159.3CCL19, IFNB1, IFNG, CXCL12, TBX21
26T cell costimulationGO:0312959.3CCL19, HLA-DRB1, CCL21
27positive regulation of transcription from RNA polymerase II promoterGO:0459449.2IL2, IFNG, IFNB1, STAT1, STAT3
28inflammatory responseGO:0069549.1CD40LG, CCR5, CCL19, CCL21
29immune responseGO:0069557.7CXCL12, MBP, IL2, CCL21, CCL19, CCR5

Molecular functions related to Polyradiculoneuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CCR5 chemokine receptor bindingGO:0317309.6STAT3, STAT1
2fatty acid bindingGO:0055049.6PMP2, ALB
3CCR7 chemokine receptor bindingGO:0317329.4CCL19, CCL21
4cytokine activityGO:0051259.3CD40LG, IL2, IFNG, IFNB1
5chemokine receptor bindingGO:0423799.2CXCL12, CCL19, CCL21
6chemokine activityGO:0080099.0CCL21, CXCL12, CCL19

Products for genes affiliated with Polyradiculoneuropathy

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  • Antibodies
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Sources for Polyradiculoneuropathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet