MCID: PRP003
MIFTS: 69

Porphyria Cutanea Tarda malady

Genetic diseases, Rare diseases, Metabolic diseases, Eye diseases, Nephrological diseases, Skin diseases, Liver diseases categories

Aliases & Classifications for Porphyria Cutanea Tarda

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Sources:
45OMIM, 9Disease Ontology, 10diseasecard, 63Wikipedia, 19GeneReviews, 41NIH Rare Diseases, 20GeneTests, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 60UMLS, 33MeSH, 38NCIt, 27ICD9CM, 55SNOMED-CT, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Porphyria Cutanea Tarda, Aliases & Descriptions:

Name: Porphyria Cutanea Tarda 45 9 10 63 41 11 43 47 22 60
Hepatoerythropoietic Porphyria 9 63 19 41 20 11 47 60
Hep 63 41 47
Pct 63 41 47
Uroporphyrinogen Decarboxylase Deficiency 63 60
Homozygous Porphyria Cutanea Tarda 63 60
Porphyria Cutanea Tarda, Type Ii 19 20
Familial Pct 63 19
 
Familial Porphyria Cutanea Tarda 60
Porphyria, Hepatoerythropoietic 45
Porphyria, Hepatic 41
Porphyria Hepatic 43
Urod Deficiency 63
Type Ii Pct 19
F-Pct 19


Classifications:



Characteristics (Orphanet epidemiological data):

47
hepatoerythropoietic porphyria:
Prevalence: <1/1000000 (Worldwide)
porphyria cutanea tarda:
Inheritance: Autosomal dominant; Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

OMIM45 176100
Disease Ontology9 DOID:5230, DOID:3132
ICD9CM27 277.1
SNOMED-CT55 61860000
Orphanet47 95159, 101330
MESH via Orphanet34 D017121, D017119
ICD10 via Orphanet26 E80.2, E80.1
UMLS via Orphanet61 C0162569, C0268324, C0162566
ICD1025 E80.1

Summaries for Porphyria Cutanea Tarda

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OMIM:45 Porphyria cutanea tarda (PCT) is characterized by light-sensitive dermatitis and the excretion of large amounts of... (176100) more...

MalaCards based summary: Porphyria Cutanea Tarda, also known as hepatoerythropoietic porphyria, is related to hepatitis and hepatitis c, and has symptoms including thin skin, skin rash and cutaneous photosensitivity. An important gene associated with Porphyria Cutanea Tarda is UROD (uroporphyrinogen decarboxylase), and among its related pathways are Metabolism of porphyrins and HIF-1-alpha transcription factor network. The drugs hydroxychloroquine and hydroxychloroquine sulfate and the compounds coproporphyrin i and uroporphyrin i have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and eye, and related mouse phenotypes are liver/biliary system and immune system.

Disease Ontology:9 An acute porphyria characterized by painful, blistering skin lesions that develop on sun-exposed skin.

NIH Rare Diseases:41 Hepatoerythropoietic porphyria (hep) is an inherited cutaneous porphyria caused by a deficiency of the enzyme uroporphyrinogen decarboxylase. it is the autosomal recessive form of familial porphyria cutanea tarda (f-pct). the manifestations of hep resemble congenital erythropoietic porphyria (cep), with symptoms of skin blistering that usually begin in infancy. treatment may include scheduled phlebotomy and low dose hydroxychloroquine. last updated: 10/26/2010

Wikipedia:63 Porphyria cutanea tarda (PCT) is the most common subtype of porphyria. The disease is named because it... more...

GeneReviews summary for hep

GeneReviews summary for porphyria-ct

Related Diseases for Porphyria Cutanea Tarda

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Diseases related to Porphyria Cutanea Tarda via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.2CYP1A2, TF, HFE
2hepatitis c32.1CYP1A2, TF, HFE
3porphyria32.1HFE, ALAD, UROD, FECH, TF, PPOX
4cutaneous porphyria31.3UROD
5viral hepatitis31.3UROD, HFE
6coproporphyria31.1ALAD, FECH, PPOX
7siderosis31.0HFE, TF, TFRC, UROD
8hepatitis b31.0CYP1A2, HFE, TFRC
9hemochromatosis30.9TF, HAMP, TFRC, HFE2, HFE
10hemosiderosis30.9TF, HFE
11hepatocellular carcinoma30.9TF, HFE, UROD, CYP1A2
12myelodysplastic syndrome30.9HFE, TFRC, TF
13porphyria, acute intermittent30.8FECH, ALAD, UROD, PPOX
14liver disease30.7TF, HAMP, CYP1A2, HFE
15hemolytic anemia30.7HFE, TFRC, TF
16liver cirrhosis30.7HFE, CYP1A2, TF
17thalassemia30.4TFRC, HAMP, HFE, TF
18hepatitis c virus11.2
19lupus erythematosus11.0
20leukemia10.8
21systemic lupus erythematosus10.8
22scleroderma10.7
23acquired immunodeficiency syndrome10.7
24cutaneous lupus erythematosus10.7
25subacute cutaneous lupus erythematosus10.7
26alopecia10.6
27hypertrichosis10.6
28peritonitis10.6
29discoid lupus erythematosus10.6
30hepatoblastoma10.6
31microvascular complications of diabetes 710.5HFE
32arthritis10.5
33myelofibrosis10.5
34lichen planus10.5
35constrictive pericarditis10.5
36acute porphyria10.5
37cholestasis10.5
38epidermolysis bullosa10.5
39pericarditis10.5
40refractory anemia10.5
41rheumatoid arthritis10.4
42breast cancer10.4
43leprosy10.4
44alopecia universalis10.4
45hodgkin lymphoma10.4
46multiple myeloma10.4
47acute liver failure10.4
48cholangiocarcinoma10.4
49chronic myelomonocytic leukemia10.4
50glomerulonephritis10.4

Graphical network of the top 20 diseases related to Porphyria Cutanea Tarda:



Diseases related to porphyria cutanea tarda

Symptoms for Porphyria Cutanea Tarda

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Symptoms by clinical synopsis from OMIM:

176100

Clinical features from OMIM:

176100

Symptoms:

 47 (show all 19)
  • skin photosensitivity
  • thin skin
  • hemolytic anemia
  • autosomal dominant inheritance
  • cutaneous rash
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • irregular/patchy skin hypopigmentation
  • irregular/in bands/reticular skin hyperpigmentation
  • abnormal scarring/cheloids/hypertrophic scars
  • cutaneous edema
  • hirsutism/hypertrichosis/increased body hair
  • cirrhosis
  • storage liver disease
  • liver/hepatic steatosis
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • acute palsy
  • obnubilation/coma/lethargia/desorientation
  • hepatic/liver neoplasm/tumor/carcinoma/cancer

HPO human phenotypes related to Porphyria Cutanea Tarda:

(show all 26)
id Description Frequency HPO Source Accession
1 thin skin hallmark (90%) HP:0000963
2 skin rash hallmark (90%) HP:0000988
3 cutaneous photosensitivity hallmark (90%) HP:0000992
4 hypopigmented skin patches hallmark (90%) HP:0001053
5 irregular hyperpigmentation hallmark (90%) HP:0007400
6 abnormal blistering of the skin hallmark (90%) HP:0008066
7 hemolytic anemia hallmark (90%) HP:0001878
8 edema occasional (7.5%) HP:0000969
9 atypical scarring of skin occasional (7.5%) HP:0000987
10 hypertrichosis occasional (7.5%) HP:0000998
11 cirrhosis occasional (7.5%) HP:0001394
12 hepatic steatosis occasional (7.5%) HP:0001397
13 sudden cardiac death occasional (7.5%) HP:0001645
14 neoplasm of the liver occasional (7.5%) HP:0002896
15 reduced consciousness/confusion occasional (7.5%) HP:0004372
16 cerebral palsy occasional (7.5%) HP:0100021
17 autosomal dominant inheritance HP:0000006
18 cutaneous photosensitivity HP:0000992
19 fragile skin HP:0001030
20 cirrhosis HP:0001394
21 hepatocellular carcinoma HP:0001402
22 alopecia HP:0001596
23 onycholysis HP:0001806
24 facial hypertrichosis HP:0002219
25 hyperpigmentation in sun-exposed areas HP:0005586
26 scleroderma HP:0100324

Drugs & Therapeutics for Porphyria Cutanea Tarda

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Drug clinical trials:

Search ClinicalTrials for Porphyria Cutanea Tarda

Search NIH Clinical Center for Porphyria Cutanea Tarda

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Porphyria Cutanea Tarda

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Genetic tests related to Porphyria Cutanea Tarda:

id Genetic test Affiliating Genes
1 Hepatoerythropoietic Porphyria20
2 Porphyria Cutanea Tarda, Type Ii20
3 Porphyria Cutanea Tarda22

Anatomical Context for Porphyria Cutanea Tarda

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MalaCards organs/tissues related to Porphyria Cutanea Tarda:

31
Skin, Liver, Eye, Testes, Bone marrow, Bone, Whole blood, Breast, Myeloid

Animal Models for Porphyria Cutanea Tarda or affiliated genes

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MGI Mouse Phenotypes related to Porphyria Cutanea Tarda:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053707.8HFE, TFRC, CYP1A2, FECH, UROD, HFE2
2MP:00053877.5TFRC, CYP1A2, FECH, HFE2, HFE, HAMP
3MP:00053976.8HAMP, TF, TFRC, CYP1A2, FECH, HFE2
4MP:00053766.6HAMP, TF, TFRC, CYP1A2, FECH, UROD
5MP:00107686.3HAMP, TF, TFRC, CYP1A2, FECH, UROD

Publications for Porphyria Cutanea Tarda

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Articles related to Porphyria Cutanea Tarda:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
Porphyria cutanea tarda and Sjogren's syndrome. (25054769)
2014
2
Porphyria cutanea tarda and spherocytosis: a non-random association? (23093332)
2013
3
Dermacase. Can you identify this condition? Porphyria cutanea tarda. (23851543)
2013
4
Non-classical congenital adrenal hyperplasia in association with porphyria cutanea tarda: co-incidence or trigger? (22783026)
2012
5
Hepatitis C, porphyria cutanea tarda and liver iron: an update. (22510500)
2012
6
Porphyria cutanea tarda: treatment options revisited. (22982098)
2012
7
Familial and sporadic porphyria cutanea tarda: clinical and biochemical features and risk factors in 152 patients. (20517178)
2010
8
Porphyria cutanea tarda--when skin meets liver. (20955974)
2010
9
Familial and sporadic porphyria cutanea tarda: characterization and diagnostic strategies. (19233912)
2009
10
Porphyria cutanea tarda as a complication of therapy for chronic hepatitis C. (18855993)
2008
11
Mast cells and transforming growth factor-beta expression: a possible relationship in the development of porphyria cutanea tarda skin lesions. (18477147)
2008
12
Effect of iron and ascorbate on uroporphyria in ascorbate-requiring mice as a model for porphyria cutanea tarda. (17187429)
2007
13
Mutations of hemochromatosis gene in volunteer blood donors and Chilean porphyria cutanea tarda patients]. (17137171)
2006
14
Porphyria cutanea tarda in a patient with HIV-infection. (15861867)
2005
15
Porphyria cutanea tarda masquerading as chronic hand eczema. (15206707)
2004
16
No significant association between CYP1A2 polymorphism and porphyria cutanea tarda. (15202857)
2004
17
Porphyria cutanea tarda as a predictor of poor response to interferon alfa therapy in chronic hepatitis C. (12737448)
2003
18
Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda. (12566081)
2003
19
Uroporphyria caused by ethanol in Hfe(-/-) mice as a model for porphyria cutanea tarda. (12540785)
2003
20
Porphyria cutanea tarda: multiplicity of risk factors including HFE mutations, hepatitis C, and inherited uroporphyrinogen decarboxylase deficiency. (11855561)
2002
21
Coexistence of hereditary coproporphyria and porphyria cutanea tarda: a new form of dual porphyria]. (11831056)
2002
22
Hepatitis C virus and GBV-C/hepatitis G virus in Argentine patients with porphyria cutanea tarda. (11509882)
2001
23
The HFE gene S65C polymorphism is rare among Bulgarian porphyria cutanea tarda patients. (11322214)
2001
24
Hemochromatosis genes and other factors contributing to the pathogenesis of porphyria cutanea tarda. (10688809)
2000
25
Uroporphyrinogen decarboxylase gene mutations in Danish patients with porphyria cutanea tarda. (11202053)
2000
26
Are the hemochromatosis (HFE) gene mutation and hepatitis C virus (HCV) infection risk factors for porphyria cutanea tarda?]. (11037612)
2000
27
Porphyria cutanea tarda. Don't forget to look at the urine. (10223097)
1999
28
Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in North America. (9620340)
1998
29
Chromosomal linkage analysis of porphyria in mice induced by hexachlorobenzene-iron synergism: a model of sporadic porphyria cutanea tarda. (9918132)
1998
30
Acquired characteristics of porphyria cutanea tarda in patients infected with hepatitis C virus]. (9674292)
1998
31
Epidemiology of hepatitis C and G in sporadic and familial porphyria cutanea tarda. (9500716)
1998
32
Porphyria cutanea tarda associated with human immunodeficiency virus infection. (9854161)
1998
33
Type of impaired porphyrin metabolism caused by hepatitis C virus is not porphyria cutanea tarda but chronic hepatic porphyria. (9301601)
1997
34
Cytochrome P450 induction, uroporphyrinogen decarboxylase depression, porphyrin accumulation and excretion, and gender influence in a 3-week rat model of porphyria cutanea tarda. (9439724)
1997
35
Genetic hemochromatosis in Italian patients with porphyria cutanea tarda: possible explanation for iron overload. (8773911)
1996
36
Hepatitis C and its association with lichen planus and porphyria cutanea tarda. (7868738)
1995
37
Conjugal porphyria cutanea tarda. (7826090)
1995
38
Porphyria cutanea tarda and peptic ulcer. (8095002)
1993
39
HCV infection in porphyria cutanea tarda. (7685054)
1993
40
Porphyria cutanea tarda in a patient with AIDS. (1357562)
1992
41
Chronic scarring dermatoses: remember porphyria cutanea tarda. (1604737)
1992
42
High-dose hydroxychloroquine treatment of porphyria cutanea tarda. (1597548)
1992
43
Uroporphyrinogen decarboxylase: a splice site mutation causes the deletion of exon 6 in multiple families with porphyria cutanea tarda. (2243121)
1990
44
Porphyria cutanea tarda and HIV infection. (2252569)
1990
45
Porphyria cutanea tarda and acquired immunodeficiency syndrome: case reports and literature review. (2256699)
1990
46
Porphyria cutanea tarda and scleroderma--chance association or related disease: a case report. (2208778)
1990
47
Acute scleritis in porphyria cutanea tarda. (2330942)
1990
48
Porphyria cutanea tarda resulting from primary hepatocellular carcinoma. (2850121)
1988
49
Generation of chemotactic activity in serum from patients with erythropoietic protoporphyria and porphyria cutanea tarda. (7442746)
1981
50
Iron metabolism in porphyria cutanea tarda and in erythropoietic protoporphyria. (4785438)
1973

Variations for Porphyria Cutanea Tarda

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UniProtKB/Swiss-Prot genetic disease variations for Porphyria Cutanea Tarda:

62 (show all 36)
id Symbol AA change Variation ID SNP ID
1URODp.Glu167LysVAR_007714
2URODp.Gly281GluVAR_007715
3URODp.Gly281ValVAR_007716
4URODp.Arg292GlyVAR_007717
5URODp.Ala80GlyVAR_007910
6URODp.Met165ArgVAR_007911
7URODp.Leu195PheVAR_007912
8URODp.Leu253GlnVAR_007913rs36033115
9URODp.Asn304LysVAR_007914
10URODp.Gly318ArgVAR_007915rs116233118
11URODp.Arg332HisVAR_007916
12URODp.Ile334ThrVAR_007917
13URODp.Pro62LeuVAR_009103
14URODp.Val134GlnVAR_009104
15URODp.His220ProVAR_009105
16URODp.Phe229LeuVAR_009106
17URODp.Tyr311CysVAR_009107
18URODp.Met324ThrVAR_009108
19URODp.Arg142GlnVAR_010985
20URODp.Leu161GlnVAR_010986
21URODp.Ser219PheVAR_010987
22URODp.Pro235SerVAR_010988
23URODp.Gly25GluVAR_022567
24URODp.Phe46LeuVAR_022568
25URODp.Ala80SerVAR_022569
26URODp.Arg144ProVAR_022570
27URODp.Gly156AspVAR_022571
28URODp.Arg193ProVAR_022572
29URODp.Leu216GlnVAR_022573
30URODp.Glu218LysVAR_022574
31URODp.Phe232LeuVAR_022575
32URODp.Ile260ThrVAR_022576
33URODp.Leu282ArgVAR_022577
34URODp.Gly303SerVAR_022578
35URODp.Gly168ArgVAR_065558
36URODp.Gly170AspVAR_065559

Clinvar genetic disease variations for Porphyria Cutanea Tarda:

6
id Gene Variation Type Significance SNP ID Assembly Location
1URODNM_000374.4(UROD): c.842G> T (p.Gly281Val)single nucleotide variantPathogenicrs121918057GRCh37Chr 1, 45480475: 45480475
2URODUROD, IVS6DS, G-C, +1deletionPathogenic
3URODNM_000374.4(UROD): c.942G> A (p.Glu314=)single nucleotide variantPathogenicrs121918062GRCh37Chr 1, 45480678: 45480678
4URODNM_000374.4(UROD): c.494T> G (p.Met165Arg)single nucleotide variantPathogenicrs121918063GRCh37Chr 1, 45479600: 45479600
5URODNM_000374.4(UROD): c.583C> T (p.Leu195Phe)single nucleotide variantPathogenicrs121918064GRCh37Chr 1, 45479689: 45479689
6URODNM_000374.4(UROD): c.912C> A (p.Asn304Lys)single nucleotide variantPathogenicrs121918065GRCh37Chr 1, 45480648: 45480648
7URODNM_000374.4(UROD): c.995G> A (p.Arg332His)single nucleotide variantPathogenicrs121918066GRCh37Chr 1, 45481061: 45481061
8HFENM_000410.3(HFE): c.845G> A (p.Cys282Tyr)single nucleotide variantPathogenic, confers sensitivity, risk factorrs1800562GRCh37Chr 6, 26093141: 26093141

Expression for genes affiliated with Porphyria Cutanea Tarda

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Search GEO for disease gene expression data for Porphyria Cutanea Tarda.

Pathways for genes affiliated with Porphyria Cutanea Tarda

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Pathways related to Porphyria Cutanea Tarda according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
8.9ALAD, UROD, FECH, PPOX
28.9FECH, TFRC, TF
38.9TF, TFRC, HAMP
4
Show member pathways
8.5FECH, PPOX, UROD, ALAD, CYP1A2

Compounds for genes affiliated with Porphyria Cutanea Tarda

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Compounds related to Porphyria Cutanea Tarda according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1coproporphyrin i43 1211.2UROD, ALAD
2uroporphyrin i4310.2ALAD, UROD
3griseofulvin43 1211.0FECH, CYP1A2
4pyrrole439.9UROD, FECH
5uroporphyrin439.9UROD, ALAD, HFE
6tcdd439.8UROD, CYP1A2
7aluminium citrate439.8TFRC, TF
8ethylenediaminetetraacetic acid439.8FECH, ALAD
9gallium439.8TFRC, TF
10deferiprone439.8TF, TFRC
11aluminium43 1210.7TFRC, TF
12bismuth43 2410.7TFRC, TF
13hydroxymethylbilane43 2410.7UROD, FECH, PPOX
14apotransferrin439.7TF, TFRC
15uroporphyrinogen-iii439.7UROD, FECH, PPOX
16antipyrine43 1210.7CYP1A2, TF
17ferric ammonium citrate439.7TF, TFRC
18phenobarbital43 28 49 1212.6TF, CYP1A2, UROD
19tbps43 2810.5TFRC, TF
20ppix439.5FECH, TFRC, PPOX
21lead439.5HFE, FECH, ALAD
22iron dextran43 1210.5UROD, TFRC, TF
23nh4cl439.5TFRC, TF
24histidine439.4FECH, HFE, UROD
25haem439.4FECH, HFE, UROD, PPOX
26dmso439.4UROD, FECH, TFRC
27s-nitroso-n-acetylpenicillamine439.4TFRC, FECH
28succinylacetone439.4TFRC, ALAD, TF
29vitamin b12439.3TF, TFRC, ALAD
30protoporphyrinogen439.3PPOX, FECH, UROD, ALAD
31formyl-coa43 2410.3ALAD, PPOX, UROD, FECH
32fe3+439.3FECH, TFRC, TF
33deferoxamine43 1210.3TFRC, FECH, TF
34testosterone43 59 24 1212.2CYP1A2, HFE, TFRC, ALAD
35bafilomycin a143 59 1211.1TF, TFRC
36ascorbic acid43 2410.1TFRC, ALAD, HFE, TF
37porphyrin439.0UROD, ALAD, HFE, FECH, PPOX
38ethanol43 49 24 1212.0CYP1A2, HAMP, UROD, HFE, ALAD
39copper43 2410.0HFE, ALAD, FECH, TF
40fe2+439.0FECH, HFE, TFRC, TF
41zinc protoporphyrin438.9FECH, ALAD, TFRC, TF
42porphobilinogen43 24 1210.9ALAD, PPOX, TFRC, FECH, UROD
43estrogen438.8UROD, HFE, TF, CYP1A2, TFRC
44oxygen43 249.7HAMP, PPOX, UROD, FECH, CYP1A2
45creatinine438.7ALAD, HAMP, TF, TFRC
465-aminolevulinic acid43 249.6HFE, UROD, FECH, TFRC, PPOX, ALAD
47alanine438.6FECH, HFE, TF, TFRC
48protoporphyrin ix43 24 1210.3TF, TFRC, FECH, UROD, ALAD, PPOX
49heme28 24 1210.1UROD, PPOX, TF, HFE, CYP1A2, ALAD
50iron43 247.6FECH, HAMP, PPOX, TF, TFRC, UROD

GO Terms for genes affiliated with Porphyria Cutanea Tarda

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Cellular components related to Porphyria Cutanea Tarda according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:00426129.9HFE, HLA-H
2basal part of cellGO:00451789.6HFE, TF
3recycling endosomeGO:00550379.6HFE, TF
4coated pitGO:00059059.3TF, TFRC
5cell surfaceGO:00099868.3HFE2, TFRC, TF

Biological processes related to Porphyria Cutanea Tarda according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell mediated cytotoxicityGO:00019169.9HFE, HLA-H
2protoporphyrinogen IX biosynthetic processGO:00067829.5PPOX, ALAD, UROD
3immune responseGO:00069559.3HAMP, HLA-H, HFE
4transferrin transportGO:00335729.1TF, TFRC
5heme biosynthetic processGO:00067839.1UROD, FECH, PPOX, ALAD
6iron ion homeostasisGO:00550729.0HFE2, FECH
7porphyrin-containing compound metabolic processGO:00067788.7CYP1A2, ALAD, UROD, FECH, PPOX
8cellular iron ion homeostasisGO:00068798.7HFE, TFRC, TF, HAMP
9small molecule metabolic processGO:00442818.5PPOX, CYP1A2, FECH, UROD, ALAD

Molecular functions related to Porphyria Cutanea Tarda according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.9HFE, HLA-H

Products for genes affiliated with Porphyria Cutanea Tarda

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Sources for Porphyria Cutanea Tarda

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet