MCID: PRT013
MIFTS: 67

Portal Hypertension malady

Gastrointestinal diseases category

Summaries for Portal Hypertension

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Portal hypertension is abnormally high blood pressure in branches of the portal vein, the large vein that brings blood from the intestine to the liver. portal hypertension itself does not cause symptoms, but complications from the condition can lead to an enlarged abdomen, abdominal discomfort, confusion, drowsiness and internal bleeding. it may be caused by a variety of conditions, but cirrhosis is the most common cause in western countries. treatment is generally directed toward the cause of the condition, although emergency treatment is sometimes needed for serious complications. last updated: 2/1/2012

MalaCards: Portal Hypertension, also known as hypertension, portal, is related to hypertension and hepatitis. An important gene associated with Portal Hypertension is SST (somatostatin), and among its related pathways are Common Pathway and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs acebutolol and amiloride and the compounds terlipressin and captopril have been mentioned in the context of this disorder. Affiliated tissues include liver, spleen and endothelial, and related mouse phenotypes are normal and homeostasis/metabolism.

Wikipedia:63 In medicine, portal hypertension is hypertension (high blood pressure) in the portal vein system, which... more...

Aliases & Classifications for Portal Hypertension

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

portal hypertension 8 42 10
hypertension, portal 42 60
hypertensive disease 60
hypertension portal 44


External Ids:

Disease Ontology8 DOID:10762
MeSH34 D006975
NCIt39 C3119
SNOMED-CT56 34742003, 155821005
ICD9CM27 572.3
ICD1025 K76.6

Related Diseases for Portal Hypertension

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17GeneCards, 18GeneDecks
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Diseases in the Portal Hypertension family:

Portal Hypertension Due to Infrahepatic Block

Diseases related to Portal Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 250)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.1ADRB3, EDN1, AGTR1, F2, UTS2
2hepatitis31.4F2
3liver cirrhosis31.2G6PC, EDN3, EDN1, SST, F2, UTS2
4pancreatitis30.8SST, CA2
5hepatocellular carcinoma30.7G6PC, F2
6cystic fibrosis30.5CA2
7ischemia30.2BDKRB2, G6PC, EDN1, AVPR1A
8glomerulonephritis30.2AGTR1, EDN3, CA2
9vascular disease30.2EDN3, EDN1, AGTR1, CMA1
10breast cancer30.2CPOX, ADRB3, EDN3
11obesity30.0ADRB3
12hepatorenal syndrome30.0EDN1, F2
13atherosclerosis30.0EDN1, AGTR1, CMA1, UTS2, ADRB3
14primary pulmonary hypertension30.0G6PC, EDN3, EDN1, UTS2
15essential hypertension30.0BDKRB2, EDN1, AGTR1, UTS2, ADRBK1, ADRB3
16brain edema30.0BDKRB2
17peptic ulcer30.0SST
18colon cancer29.9CPOX, CA2
19adenoma29.9SST, EDN3, G6PC
20hypersplenism10.7
21liver disease10.7
22hepatitis a10.7
23portal vein thrombosis10.7
24esophagitis10.6
25hepatopulmonary syndrome10.5
26splenic artery aneurysm10.5
27arteriovenous fistula10.5
28gastric antral vascular ectasia10.5
29tuberculosis10.4
30congenital hepatic fibrosis10.4
31hepatitis c10.4
32biliary atresia10.4
33protein c deficiency10.4
34renal hypertension10.4
35hepatitis b10.3
36hepatic vein thrombosis10.3
37abdominal tuberculosis10.3
38sarcoidosis10.3
39systemic mastocytosis10.3
40hereditary hemorrhagic telangiectasia10.3
41primary biliary cirrhosis10.3
42felty's syndrome10.3
43cystinosis10.3
44choledochal cyst10.3
45dyskeratosis congenita10.2
46mixed connective tissue disease10.2
47fatty liver disease10.2
48splenic infarction10.2
49protein-losing enteropathy10.2
50duodenitis10.2

Graphical network of the top 20 diseases related to Portal Hypertension:



Diseases related to portal hypertension

Clinical Features for Portal Hypertension

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Drugs & Therapeutics for Portal Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Portal Hypertension

Drug clinical trials:

Search ClinicalTrials for Portal Hypertension

Search NIH Clinical Center for Portal Hypertension

Search CenterWatch for Portal Hypertension

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Portal Hypertension

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Anatomical Context for Portal Hypertension

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32MalaCards
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MalaCards organs/tissues related to Portal Hypertension:

32
Liver, Spleen, Endothelial, Pancreas, Brain, Colon, Bone, Kidney, Myeloid, Testes, Thyroid, Breast, T cells, Placenta, Lymph node, Small intestine, Smooth muscle, Bone marrow

Animal Models for Portal Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Portal Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.3G6PC, EDN1, SST, AVPR1A, F2, ADRBK1
2MP:000537610.0ADRB3, BDKRB2, CA2, CTC1, G6PC, EDN1

Publications for Portal Hypertension

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50PubMed
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Articles related to Portal Hypertension:

(show top 50)    (show all 836)
idTitleAuthorsYear
1
Traumatic complex splenic arteriovenous fistula causing prehepatic portal hypertension and variceal bleeding: the importance of the diagnosis for the endovascular treatment approach. (24327739)
2014
2
Invasive and non-invasive techniques for detecting portal hypertension and predicting variceal bleeding in cirrhosis: A review. (24328372)
2014
3
A woman with didanosine retinopathy and non-cirrhotic portal hypertension. (24400350)
2013
4
Study of upper gastrointestinal tract endoscopic findings in portal hypertension. (24362656)
2013
5
Transient elastography: a meta-analysis of diagnostic accuracy in evaluation of portal hypertension in chronic liver disease. (22973991)
2013
6
Beta-blockers in portal hypertension: new developments and controversies. (24134058)
2013
7
Hepatic and splenic stiffness augmentation assessed with MR elastography in an in vivo porcine portal hypertension model. (23418135)
2013
8
Outcome of laparoscopic splenectomy with sandwich treatment including pericardial devascularization and limited portacaval shunt for portal hypertension due to liver cirrhosis. (23248978)
2013
9
Noncirrhotic portal hypertension associated with didanosine: a case report and literature review. (22274160)
2012
10
Liver metastases, a rare cause of portal hypertension and stoma bleeding. Brief review of literature. (22387413)
2012
11
Treatment of portal hypertension. (22468079)
2012
12
Agenesis of right hepatic lobe accompanied by cirrhosis of the left hepatic lobe and portal hypertension. (23265101)
2012
13
Oesophageal varices: a complication of portal hypertension. (22428198)
2012
14
Prevalence and indicators of portal hypertension in patients with nonalcoholic fatty liver disease. (22610002)
2012
15
Noncirrhotic Portal Hypertension due to Nodular Regenerative Hyperplasia Treated with Surgical Portacaval Shunt. (22956964)
2012
16
Idiopathic portal hypertension complicated by ischemic hepatitis: the diagnostic importance of hemodynamics and liver biopsy. (22300122)
2012
17
Hepatic sarcoidosis presenting as portal hypertension and liver cirrhosis: case report and review of the literature. (22679408)
2012
18
Assessment of intrahepatic blood flow by Doppler ultrasonography: relationship between the hepatic vein, portal vein, hepatic artery and portal pressure measured intraoperatively in patients with portal hypertension. (21767412)
2011
19
Circulating nitric oxide products do not solely reflect nitric oxide release in cirrhosis and portal hypertension. (21745317)
2011
20
Bleeding from peristomal varices: a complication of portal hypertension. (22679272)
2011
21
Safety and effectiveness of splenic vein to inferior mesenteric vein anastomosis during pancreaticoduodenectomy: comment on "Splenic vein-inferior mesenteric vein anastomosis to lessen left-sided portal hypertension after pancreaticoduodenectomy with concomitant vascular resection". (22184298)
2011
22
MR angiography of esophageal mural veins in portal hypertension: a correlation with endoscopic grades of esophageal varices. (20931432)
2010
23
Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: new targets for the treatment of portal hypertension? (20800926)
2010
24
Relevance of the mTOR signaling pathway in the pathophysiology of splenomegaly in rats with chronic portal hypertension. (20206401)
2010
25
Portal hypertension in 18-month-old rats: memory deficits and brain metabolic activity. (20184905)
2010
26
Risk factors for portal venous thrombosis after splenectomy in patients with cirrhosis and portal hypertension (Br J Surg 2010; 97: 910-916). (20683871)
2010
27
A case of oesophageal varices and portal hypertension in an HIV-positive patient with no evidence of cirrhosis. (21326407)
2010
28
Time trends in hospitalization and discharge status for cirrhosis and portal hypertension in the United States. (21038425)
2010
29
The gastric mucosa in portal hypertension: structural and ultrastructural observations. (20495742)
2010
30
Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension. (20561700)
2010
31
Intussusception and colonic ischemia in portal hypertension: a case report. (20358725)
2010
32
A 3-month course of long-acting repeatable octreotide (sandostatin LAR) improves portal hypertension in patients with cirrhosis: a randomized controlled study. (17488248)
2007
33
Treatment of gastropathy and gastric antral vascular ectasia in patients with portal hypertension. (18221609)
2007
34
The puzzle of endothelial nitric oxide synthase dysfunction in portal hypertension: The missing piece? (17879360)
2007
35
A case of dyskeratosis congenita with portal hypertension associated with jugular venous anomaly. (16830282)
2006
36
GRK2 makes trouble: a no-NO in portal hypertension. (16530538)
2006
37
Portal hypertensive gastropathy (PHG). (15648238)
2004
38
Adult polycystic liver disease presenting as portal hypertension. (15717586)
2004
39
A case of merged idiopathic portal hypertension in course of mixed connective tissue disease. (15341774)
2004
40
Splenic vascular malformations and portal hypertension in hereditary hemorrhagic telangiectasia: sonographic findings. (11180187)
2001
41
Hemodynamic effects of the angiotensin II receptor antagonist irbesartan in patients with cirrhosis and portal hypertension. (11487548)
2001
42
Myxedema accompanied by huge portal-systemic shunt without portal hypertension. (11813844)
2001
43
Splanchnic hyposensitivity to glypressin in a haemorrhage/transfused rat model of portal hypertension: role of nitric oxide and bradykinin. (11099389)
2000
44
Hemodynamic study of splenic artery aneurysm in portal hypertension. (8056411)
1994
45
"Endemic" idiopathic portal hypertension: report on 32 patients with non-cirrhotic portal fibrosis. (1290252)
1992
46
Nodular regenerative hyperplasia of the liver with and without portal hypertension: a comparison. (3963734)
1986
47
Gaucher's disease in pregnancy associated with portal hypertension. (3706442)
1986
48
Nodular regenerative hyperplasia of the liver: a cause of noncirrhotic portal hypertension. (6499201)
1984
49
Evaluation of splenic embolization in patients with portal hypertension and hypersplenism. (7125739)
1982
50
Portal hypertension in Felty's syndrome. (7416125)
1980

Genetic Variations for Portal Hypertension

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Expression for genes affiliated with Portal Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Portal Hypertension

Search GEO for disease gene expression data for Portal Hypertension.

Pathways for genes affiliated with Portal Hypertension

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53Reactome, 51QIAGEN, 49PharmGKB, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Portal Hypertension according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4F2, FGB
2
Hide members
10.4CMA1, AGTR1, BDKRB2
3
Hide members
10.4F2, FGB, BDKRB2
4
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10.4AGTR1, F2, ADRBK1
510.4BDKRB2, AGTR1, AVPR1A, ADRB3
6
Hide members
10.4UTS2R, AVPR1A, AGTR1, BDKRB2
7
Hide members
10.4EDN3, EDN1, AGTR1, FGB, F2
8
Hide members
10.3ADRBK1, BDKRB2, EDN3, EDN1, AGTR1, AVPR1A
9
Hide members
10.3BDKRB2, EDN3, EDN1, AGTR1, SST, AVPR1A
10
Hide members
10.2SST, AGTR1, EDN1, EDN3, BDKRB2, FGB

Compounds for genes affiliated with Portal Hypertension

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44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Portal Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1terlipressin44 1111.9SST, AVPR1A, F2
2captopril44 28 49 59 1114.9SST, EDN1, EDN3, BDKRB2
3norepinephrine44 11 2412.8ADRB3, EDN3, CA2, UTS2, ADRBK1
4thromboxane a244 2411.8BDKRB2, EDN3, AGTR1, EDN1, CPOX
5sodium nitroprusside4410.8BDKRB2, AGTR1, EDN3, SST, EDN1
6nifedipine44 49 28 1113.8BDKRB2, EDN1, SST, AGTR1, EDN3
7chymostatin4410.8CMA1, AGTR1, EDN1
8phenylephrine44 28 11 2413.8UTS2, AGTR1, EDN1, EDN3
9l-nmma4410.8EDN1, EDN3, BDKRB2, AGTR1
10epinephrine44 11 2412.8F2, ADRBK1, ADRB3, EDN1, SST, AGTR1
11isoproterenol44 1111.8ADRB3, ADRBK1, EDN1, BDKRB2, SST, AGTR1
12cgmp44 2811.8EDN1, EDN3, BDKRB2, AGTR1, ADRB3
13heparin44 28 11 2413.8ADRBK1, CMA1
14acetylcholine44 49 28 11 2414.8EDN1, AGTR1, SST, UTS2, EDN3, ADRBK1
15n(g)-nitro-l-arginine methyl ester4410.8EDN1, BDKRB2, UTS2
16histamine44 28 2412.8ADRBK1, BDKRB2, EDN3, EDN1, SST, CMA1
17inositol 1,4,5 trisphosphate4410.8AGTR1, EDN1, EDN3, BDKRB2, ADRBK1
18dexamethasone44 49 28 1113.8ADRB3, BDKRB2, G6PC, EDN3
19creatinine4410.8EDN1, UTS2, MDH2, F2, AGTR1, CA2
20phosphoinositide4410.8UTS2, ADRBK1, EDN1, BDKRB2, EDN3, G6PC
21pge24410.8EDN1, BDKRB2, CPOX, SST, EDN3, CA2
22palosuran44 2811.8UTS2R, UTS2
23sb 7063755910.7UTS2R, UTS2
24lactate4410.7G6PC, MDH2, F2, CPOX, CA2, SST
25sb 6575105910.7UTS2R, UTS2
26indomethacin44 59 28 1113.7CPOX, UTS2, EDN1, EDN3, BDKRB2
27bq 4854410.7EDN1, EDN3
28glutamate4410.7EDN3, ADRBK1, CPOX, AGTR1, SST, MDH2
29arginine4410.7EDN3, BDKRB2, CA2, G6PC, CPOX, ADRB3
30nitric oxide44 11 2412.7BDKRB2, EDN1, AGTR1, UTS2, EDN3, CPOX
31atp44 2811.7MDH2, G6PC, ADRB3, BDKRB2, AGTR1, ADRBK1
32[orn8]-urotensin ii5910.7UTS2, UTS2R
33glucose4410.7ADRBK1, ADRB3, UTS2R, CPOX, AGTR1, MDH2
34alanine4410.7EDN3, ADRB3, ADRBK1, F2, AGTR1, MDH2
35urotensin ii (human)5910.7UTS2, UTS2R
36aspartate4410.7G6PC, CA2, F2, MDH2, EDN3, ADRBK1
37(+-)-ac 7954 hydrochloride5910.7UTS2, UTS2R
38adenylate4410.7CA2, ADRB3, BDKRB2, G6PC, EDN3, SST
39calcium44 49 11 2413.6G6PC, EDN3, EDN1, CPOX, ADRBK1, UTS2R
40lipid4410.6AGTR1, UTS2, BDKRB2, CA2, G6PC, ADRBK1
41diltiazem44 28 1112.6AGTR1, F2, EDN1
42lead4410.6CA2, G6PC, ADRBK1, CPOX
43carvedilol44 49 28 1113.6ADRB3, EDN1, AGTR1
44endothelin 2 (human)5910.6EDN3, EDN1
45oxygen44 2411.5CPOX, AGTR1, ADRB3, UTS2, EDN1, G6PC
46sarafotoxin s6a5910.5EDN1, EDN3
47endothelin 3 (human, rat)5910.4EDN3, EDN1
48carbachol44 28 1112.4SST, ADRBK1, EDN1, EDN3
49endothelin 1 (human, porcine)5910.3EDN3, EDN1
50citrate4410.1MDH2, CA2, CPOX, F2

GO Terms for genes affiliated with Portal Hypertension

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16Gene Ontology
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Cellular components related to Portal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.4EDN1, SST, FGB, F2, CMA1, UTS2
2extracellular spaceGO:00561510.2UTS2, CA2, EDN3, EDN1, SST, PCSK1N
3plasma membraneGO:00588610.0BDKRB2, CA2, MDH2, AGTR1, FGB, AVPR1A

Biological processes related to Portal Hypertension according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of heart rateGO:01046010.8EDN3, EDN1, AVPR1A, UTS2
2positive regulation of circadian sleep/wake cycle, wakefulnessGO:01084110.8UTS2R, UTS2
3positive regulation of cellular pH reductionGO:03284910.8AVPR1A, CA2
4regulation of vasoconstrictionGO:01922910.8BDKRB2, EDN3, EDN1, AGTR1
5vasoconstrictionGO:04231010.8EDN1, EDN3, BDKRB2
6positive regulation of circadian sleep/wake cycle, REM sleepGO:04600510.8UTS2R, UTS2
7cell surface receptor signaling pathwayGO:00716610.8BDKRB2, EDN3, EDN1, SST, F2
8blood circulationGO:00801510.8UTS2R, AVPR1A, EDN3, BDKRB2
9elevation of cytosolic calcium ion concentrationGO:00720410.8UTS2R, UTS2, AVPR1A, AGTR1, EDN1, BDKRB2
10G-protein coupled receptor signaling pathwayGO:00718610.7BDKRB2, EDN1, AGTR1, SST, AVPR1A
11calcium-mediated signalingGO:01972210.7AVPR1A, AGTR1, EDN1
12positive regulation of fibroblast proliferationGO:04814610.7CTC1, UTS2, UTS2R
13negative regulation of renal sodium excretionGO:03581410.7UTS2, UTS2R
14peptide hormone secretionGO:03007210.7EDN3, EDN1
15vein smooth muscle contractionGO:01482610.7EDN3, EDN1
16negative regulation of glomerular filtrationGO:00310510.7UTS2, UTS2R
17negative regulation of urine volumeGO:03581110.7UTS2, UTS2R
18regulation of systemic arterial blood pressure by endothelinGO:00310010.7EDN3, EDN1
19artery smooth muscle contractionGO:01482410.6EDN1, EDN3
20positive regulation of cell growthGO:03030710.6AVPR1A, F2, UTS2R
21inositol phosphate-mediated signalingGO:04801610.6EDN1, EDN3
22positive regulation of hormone secretionGO:04688710.6EDN1, EDN3
23regulation of vasodilationGO:04231210.5AGTR1, UTS2R
24positive regulation of blood pressureGO:04577710.4UTS2R, UTS2
25positive regulation of angiogenesisGO:04576610.4CMA1, UTS2, UTS2R
26positive regulation of renal sodium excretionGO:03581510.4AVPR1A, EDN1
27elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.1AGTR1, EDN1

Molecular functions related to Portal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00510210.4UTS2, F2, FGB, PCSK1N, EDN3
2hormone activityGO:00517910.1UTS2, SST, EDN1, EDN3

Products for genes affiliated with Portal Hypertension

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  • Antibodies
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Sources for Portal Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet