MCID: PRT018
MIFTS: 54

Portal Vein Thrombosis malady

Cardiovascular diseases, Liver diseases, Rare diseases, Blood diseases categories
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Summaries for Portal Vein Thrombosis

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Portal vein thrombosis is a form of venous thrombosis affecting the hepatic portal vein, which can lead... more...

MalaCards: Portal Vein Thrombosis, also known as portal hypertension due to infrahepatic block, is related to hepatocellular carcinoma and hepatitis. An important gene associated with Portal Vein Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Integrin alphaIIb beta3 signaling. The compounds certoparin and deae-sephadex a-50 have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and spleen, and related mouse phenotypes are cardiovascular system and embryogenesis.

Disease Ontology:8 A vein disease that is characterized by a blood clot that forms within the hepatic portal vein.

Aliases & Classifications for Portal Vein Thrombosis

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8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 27ICD9CM, 58SNOMED-CT, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Orphanet: 49 
Rare hepatic diseases


Characteristics (Orphanet epidemiological data):

49
portal vein thrombosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

portal vein thrombosis 8 10 45 49 62
portal hypertension due to infrahepatic block 49


External Ids:

Disease Ontology8 DOID:11695
NCIt40 C78565
ICD9CM27 452
ICD10 via Orphanet26 I81
SNOMED-CT58 17920008, 155455003
SNOMED-CT via Orphanet59 17920008
UMLS via Orphanet63 C0155773
ICD1025 I81

Related Diseases for Portal Vein Thrombosis

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17GeneCards, 18GeneDecks
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Diseases related to Portal Vein Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1hepatocellular carcinoma31.5F2, ABCB7, F8
2hepatitis31.5F2, THPO
3portal hypertension31.2THPO, F2
4liver cirrhosis31.2ABCB7, F2, SERPINC1, THPO
5purpura30.8SERPINC1, THPO
6protein c deficiency30.8F5, F2, SERPINC1
7protein s deficiency30.7F5, SERPINC1
8thrombophilia30.7F5, F8, SERPINC1, F2
9hyperhomocysteinemia30.7SERPINC1, F2, F8, F5
10hepatitis b30.7ABCB7, F2
11hepatitis c30.6ABCB7, F2, THPO
12hypersplenism30.6THPO, F2
13antithrombin iii deficiency30.6SERPINC1, F2, F5
14lupus erythematosus30.5F2, F5, SERPINC1
15thrombocytosis30.5SERPINC1, THPO, F2
16antiphospholipid syndrome30.5SERPINC1, F8, F5, F2
17thromboembolism30.5F8, F5, F2, SERPINC1
18eclampsia30.5SERPINC1
19myocardial infarction30.5SERPINC1, F5, ABCB7, F8
20homocystinuria30.4F5, SERPINC1
21pulmonary embolism30.3F2, F5, SERPINC1
22acute myocardial infarction30.3SERPINC1, ABCB7
23sepsis30.3F2, SERPINC1, F5
24pre-eclampsia30.2F2, SERPINC1, F8, F5
25cerebrovascular disease30.2F2, SERPINC1, F8, F5
26disseminated intravascular coagulation30.1F5, SERPINC1, THPO, F2, F8
27hypertension10.8
28pancreatitis10.8
29portal hypertension due to infrahepatic block10.6
30ulcerative colitis10.6
31liver disease10.6
32tuberculosis10.6
33myeloproliferative disorder10.6
34cholecystitis10.5
35acute pancreatitis10.4
36biliary atresia10.4
37abdominal tuberculosis10.4
38inflammatory bowel disease10.4
39obesity10.4
40thalassemia10.4
41chylous ascites10.4
42cytomegalovirus infection10.4
43crohn's disease10.4
44morbid obesity10.4
45cholelithiasis10.4
46beta thalassemia10.4
47systemic lupus erythematosus10.4
48adult-onset still's disease10.4
49hepatic encephalopathy10.4
50renal cell carcinoma10.4

Graphical network of the top 20 diseases related to Portal Vein Thrombosis:



Diseases related to portal vein thrombosis

Symptoms for Portal Vein Thrombosis

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Drugs & Therapeutics for Portal Vein Thrombosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Portal Vein Thrombosis

Search NIH Clinical Center for Portal Vein Thrombosis

Genetic Tests for Portal Vein Thrombosis

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Anatomical Context for Portal Vein Thrombosis

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33MalaCards
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MalaCards organs/tissues related to Portal Vein Thrombosis:

33
Liver, Colon, Spleen, Pancreas, Lymph node, Whole blood, Breast, Myeloid

Animal Models for Portal Vein Thrombosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Portal Vein Thrombosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5F5, SERPINC1, ABCB7, F2
2MP:00053808.4F2, ABCB7, SERPINC1, F5
3MP:00053767.9F5, F8, SERPINC1, ABCB7, F2
4MP:00107687.6F2, ABCB7, SERPINC1, F8, F5

Publications for Portal Vein Thrombosis

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52PubMed
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Articles related to Portal Vein Thrombosis:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Portal Vein Thrombosis After Hepatectomy. (24407940)
2014
2
Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib. (23914915)
2013
3
Impact of portal vein thrombosis on the efficacy of endoscopic variceal band ligation. (24084343)
2013
4
Portomesenteric shunt for liver transplantation and complete portal vein thrombosis. (24247901)
2013
5
Portal Vein Thrombosis: A Clinician-Oriented and Practical Review. (23364162)
2013
6
Successful treatment of acute portal vein thrombosis with rivaroxaban. (23846289)
2013
7
Does decreased fibrinolysis have a role to play in the development of non-neoplastic portal vein thrombosis in patients with hepatic cirrhosis? (23504244)
2013
8
Implementation of laparoscopic splenectomy in children and the incidence of portal vein thrombosis diagnosed by ultrasonography. (24210199)
2013
9
Orthotopic liver transplantation in patients with portal vein thrombosis in the absence of hepatocellular carcinoma. (23146508)
2012
10
Optimal length of anticoagulant therapy in cirrhotic patients with portal vein thrombosis. (22387253)
2012
11
Obesity is an independent risk factor for pre-transplant portal vein thrombosis in liver recipients. (22909075)
2012
12
Huge inflammatory pseudotumor of the spleen with postoperative portal vein thrombosis: report of a case. (22160356)
2012
13
Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis. (22819864)
2012
14
Portal vein thrombosis in inflammatory bowel diseases: a single-center case series. (22405175)
2012
15
The inferior mesenteric vein to the left gonadal vein shunt for gastroesophageal varices and extrahepatic portal vein thrombosis after living donor liver transplantation: a case report. (22410077)
2012
16
Evaluation of portal vein thrombosis in liver graft ten years after liver transplantation due to budd-Chiari syndrome using Doppler ultrasound. (23322979)
2012
17
Antiannexin V antibodies: an underestimated source of noncirrhotic portal vein thrombosis? (22371219)
2012
18
An early single-center experience of portal vein thrombosis in living donor liver transplantation: clinical feature, management and outcome. (22066098)
2011
19
Portal vein thrombosis and budd-Chiari syndrome. (22054734)
2011
20
Caval inflow to the graft for liver transplantation in patients with diffuse portal vein thrombosis: a 12-year experience. (21869678)
2011
21
Case of asymptomatic portal vein thrombosis after cesarean delivery. (21599802)
2011
22
A rare cause of portal vein thrombosis in a previously healthy young man with acute hepatitis. (21493127)
2011
23
Portal vein thrombosis in biliary atresia patients after living donor liver transplantation. (20570300)
2011
24
Extrahepatic portal vein thrombosis after umbilical catheterization: is it a good choice for Rex shunt? (21238670)
2011
25
Correlation of splenectomy with portal vein thrombosis in beta-thalassemia major. (22355997)
2011
26
Isolated periportal tuberculosis causing portal vein thrombosis. (22039034)
2011
27
Chemoembolization for unresectable hepatocellular carcinoma in patients with or without portal vein thrombosis. (21443089)
2010
28
Transjugular intrahepatic portosystemic shunt with thrombectomy for the treatment of portal vein thrombosis after liver transplantation. (19242796)
2010
29
Posttransplant bilioportal fistula with portal vein thrombosis: a case report. (21094871)
2010
30
VKORC1 and CYP2C9 genetic polymorphisms in hepatic or portal vein thrombosis. (20434758)
2010
31
Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study. (19821530)
2010
32
Portal vein thrombosis and liver transplantation: long term. (20304176)
2010
33
Liver transplantation in end-stage liver disease with portal vein thrombosis]. (19595038)
2009
34
Portal vein thrombosis and budd-Chiari syndrome. (19150317)
2009
35
Portal vein thrombosis in the district general hospital: management and clinical outcomes. (19262399)
2009
36
Liver transplant recipients with portal vein thrombosis: a single center retrospective study. (19208512)
2009
37
Pancreatic laceration and portal vein thrombosis in blunt trauma abdomen. (20011472)
2008
38
Portal vein thrombosis: CT features. (17694406)
2008
39
Management of portal vein thrombosis. (21960890)
2008
40
Late onset portal vein thrombosis and its risk factors. (18705318)
2008
41
Superior mesenteric and portal vein thrombosis caused by congenital antithrombin III deficiency: report of a case. (17387563)
2007
42
High FVIII level is associated with idiopathic portal vein thrombosis in South India. (17524760)
2007
43
Experimental hepatic radiofrequency ablation using wet electrodes: electrode-to-vessel distance is a significant predictor for delayed portal vein thrombosis. (16541225)
2006
44
Acute idiopathic portal vein thrombosis in a child: a case report and literature review. (16378832)
2006
45
Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy. (16557541)
2006
46
Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India. (16877827)
2006
47
Extrahepatic portal vein thrombosis in children: etiology and long-term follow-up. (15087698)
2004
48
Portal vein thrombosis after variceal endoscopic sclerotherapy in cirrhotic patients: role of genetic thrombophilia. (12170404)
2002
49
Portal vein thrombosis associated with hilar bile duct carcinoma and liver abscess. (11269004)
2001
50
Portal vein thrombosis caused by protein C and protein S deficiency associated with cytomegalovirus infection. (7699538)
1995

Variations for Portal Vein Thrombosis

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Expression for genes affiliated with Portal Vein Thrombosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Portal Vein Thrombosis

Search GEO for disease gene expression data for Portal Vein Thrombosis.

Pathways for genes affiliated with Portal Vein Thrombosis

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50PathCards, 55Reactome, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54R&D Systems
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Compounds for genes affiliated with Portal Vein Thrombosis

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Sources:
45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 3BitterDB, 51PharmGKB, 24HMDB
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Compounds related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1certoparin459.7F2, SERPINC1
2deae-sephadex a-50459.6F2, F8
3polybrene459.5SERPINC1, F2
4inogatran459.5F2, SERPINC1, F5
5hirugen459.5F2, SERPINC1, F5
6ecarin459.5F5, SERPINC1, F2
7spectrozyme459.5SERPINC1, F2, F5
8danaparoid459.5F5, SERPINC1, F2
9ximelagatran45 1110.5F5, F2, SERPINC1
10ancrod459.5F2, F5, SERPINC1
11heparinoids459.5SERPINC1, F5, F2
12fondaparinux459.5F5, F2, SERPINC1
13bivalirudin45 1110.5F5, SERPINC1, F2
14desogestrel45 1110.5F5, SERPINC1, F2
15argatroban45 1110.5SERPINC1, F5, F2
16protamine sulfate459.5F2, SERPINC1, F5
17gestodene45 1110.4F2, SERPINC1, F5
18levonorgestrel45 61 29 1112.4SERPINC1, F5, F2
19hydroxyethyl starch459.4F8, SERPINC1, F2
20coumarin45 3 51 2412.4SERPINC1, F5, F2
21kaolin459.4F2, F5, F8
22tranexamic acid45 1110.4F8, F2, SERPINC1
23protamine459.3F5, SERPINC1, F2
24dermatan sulfate459.3F2, SERPINC1, F5
25kininogen459.3SERPINC1, F2, F5
26cardiolipin45 1110.3F2, F5, F8
27phosphatidylethanolamine45 1110.3F5, F8, F2
28rfviii459.2F8, F5
29aprotinin45 1110.2SERPINC1, F2, F5
30acetaminophen45 3 51 24 1113.1F8, F2, F5
31progestin459.1F5, F8, SERPINC1
32ristocetin459.0F5, F8, SERPINC1, F2
33desmopressin45 61 29 1112.0SERPINC1, F8, F5, F2
34warfarin45 51 24 1112.0SERPINC1, F5, F8, F2
35homocysteine45 249.9F5, F8, SERPINC1, F2
36citrate458.9F2, SERPINC1, F8, F5
37prostacyclin458.6F5, SERPINC1, F8, THPO
38tamoxifen45 51 29 1111.5THPO, F5, SERPINC1, F2
39polysaccharide458.5THPO, F8, SERPINC1, F5
40epinephrine45 24 1110.5F2, F5, THPO, F8
41aspartate458.3F5, F8, ABCB7, F2
42hirudin458.2F5, F2, THPO, SERPINC1, F8
43polyethylene glycol458.2THPO, SERPINC1, F5, F2, F8
44aspirin45 51 29 2411.2F2, SERPINC1, F8, THPO, F5
45estrogen458.0SERPINC1, F8, F2, THPO, F5
46lactate457.9ABCB7, F2, THPO, F5, F8
47fibrinogen457.6F8, SERPINC1, ABCB7, F2, THPO, F5
48creatinine457.6F2, F5, F8, SERPINC1, THPO, ABCB7
49heparin45 29 24 1110.6F5, THPO, F8, SERPINC1, ABCB7, F2
50alanine457.5F2, ABCB7, THPO, F8, F5, SERPINC1

GO Terms for genes affiliated with Portal Vein Thrombosis

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16Gene Ontology
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Cellular components related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.5SERPINC1, F2
2platelet alpha granule lumenGO:0310939.4F8, F5
3extracellular regionGO:0055768.3F5, F8, SERPINC1, F2
4extracellular spaceGO:0056157.7F5, F8, SERPINC1, THPO, F2

Biological processes related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:0075979.4F8, F2
2acute-phase responseGO:0069539.3F2, F8
3platelet degranulationGO:0025769.2F5, F8
4positive regulation of protein phosphorylationGO:0019349.1THPO, F2
5platelet activationGO:0301688.2F2, THPO, F8, F5
6blood coagulationGO:0075967.9F5, F8, SERPINC1, THPO, F2

Molecular functions related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.5F5, F8
2serine-type endopeptidase activityGO:0042528.7F5, F8, F2

Products for genes affiliated with Portal Vein Thrombosis

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  • Antibodies
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Sources for Portal Vein Thrombosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet