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Portal Vein Thrombosis malady
27 genes, 2 tissues, 582 related diseases, 5 phenotypes, 56 articles, clinical trials.

Summaries for Portal Vein Thrombosis

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44Wikipedia, 22MalaCards
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Wikipedia: Portal vein thrombosis is a form of venous thrombosis affecting the hepatic portal vein, which can lead...44 more...

MalaCards: Portal Vein Thrombosis is related to thrombosis and hepatitis. An important gene associated with Portal Vein Thrombosis is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Intrinsic Prothrombin Activation Pathway and Extrinsic Prothrombin Activation Pathway. The compounds cyclophosphamide and hirudin have been mentioned in the context of this disorder. Affiliated tissues include liver and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Descriptions for Portal Vein Thrombosis

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 19ICD9CM, 40SNOMED-CT, 27NCIt
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Aliases & Descriptions:

portal vein thrombosis 6 8 32 43

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ICD9CM19 452

Related Diseases for Portal Vein Thrombosis

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13GeneCards, 14GeneDecks
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Diseases related to portal vein thrombosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 579)
idRelated DiseaseScoreTop Affiliating Genes
1thrombosis39.0MTHFR, F8, F5, F2
2hepatitis31.4SELP, IFNA1, IFNA2, F2, ALB, THPO
3antithrombin iii deficiency30.5SERPINC1, MTHFR, JAK2, APOH, F5, F2
4chylous ascites29.9ALB, SST
5myeloproliferative disorder29.6SELP, JAK2, IFNA1, IFNA2, THPO, EPO
6portal hypertension29.5F2, ALB, SST, THPO
7liver cirrhosis28.0REN, SERPINC1, IFNA1, IFNA2, F3, F2
8morbid obesity27.8REN, SERPINE1, F5, F2, ALB, CRP
9thrombophilia27.8SELP, SERPINC1, SERPINE1, MTHFR, JAK2, APOH
10cerebrovascular disease27.2REN, SELP, SERPINC1, SERPINE1, MTHFR, APOH
11polycythemia27.0SELP, SERPINC1, SERPINE1, JAK2, IFNA1, IFNA2
12polycythemia vera27.0SELP, SERPINC1, SERPINE1, JAK2, IFNA1, IFNA2
13hyperhomocysteinemia25.7SELP, SERPINC1, SERPINE1, MTHFR, APOH, F8
14hepatocellular carcinoma25.4PCNA, SELP, SERPINC1, SERPINE1, VKORC1, MTHFR
15acute myocardial infarction23.9REN, SELP, SERPINC1, SERPINE1, MTHFR, JAK2
16carcinoma23.9REN, PCNA, SELP, SERPINC1, SERPINE1, VKORC1
17myocardial infarction23.3REN, SELP, SERPINC1, SERPINE1, VKORC1, MTHFR
18obesity22.1REN, PCNA, SELP, SERPINC1, SERPINE1, MTHFR
19hypertension21.0REN, PCNA, SELP, SERPINC1, SERPINE1, MTHFR
20stroke, ischemic13.7F5, F2
21legg-calve-perthes disease13.7SERPINC1, F5
22postphlebitic syndrome13.7SERPINC1, F5
23mondor disease13.7APOH, F5
24antiphospholipid syndrome13.6APOH, F2
25acquired angioedema13.6SERPINC1, F5
26hyperprothrombinemia13.6SERPINC1, F2
27essential thrombocythemia13.6JAK2, THPO
28placental infarction13.6SERPINC1, APOH, F5
29chondrodysplasia punctata 1, x-linked13.6F8, F2, AFP
30hemoglobin e disease13.6F5, F2
31vitamin k-dependent clotting factors13.6VKORC1, F5, F2
32giant hemangioma13.5IFNA2, ABCB7
33placental abruption13.5SERPINC1, MTHFR, F5
34prothrombin deficiency13.5F3, F2
35bernard-soulier syndrome13.5F8, F2, THPO
36blood protein disease13.5MTHFR, F5, F2
37porencephaly13.5MTHFR, F5, F2
38homocysteine plasma level13.5SERPINC1, MTHFR, F5
39sagittal sinus thrombosis13.5SERPINC1, F5, F3
40rh isoimmunization13.5EPO, AFP
41factor xii deficiency13.5F5, F3, F2
42factor x deficiency13.5F5, F3, F2
43acquired polycythemia13.5JAK2, EPO
44acquired hemophilia13.5F8, F5, F3
45acquired von willebrand syndrome13.5F8, F3, F2
46hemarthrosis13.4F8, F3, F2
47syphilis13.4APOH, F2, ABCB7
48type 1 von willebrand disease13.4MTHFR, F8
49discoid lupus erythematosus of eyelid13.4APOH, IFNA2
50type 3 von willebrand disease13.4F8, PLAT

Graphical network of the top 20 diseases related to portal vein thrombosis:



Graphical network of diseases related to portal vein thrombosis

Clinical Features for Portal Vein Thrombosis

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Drugs & Therapeutics for Portal Vein Thrombosis

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for portal vein thrombosis

Drug clinical trials:

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Search NIH Clinical Center for portal vein thrombosis

Search CenterWatch for portal vein thrombosis

Genetic Tests for Portal Vein Thrombosis

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Anatomical Context for Portal Vein Thrombosis

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22MalaCards
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MalaCards organs/tissues related to portal vein thrombosis:

22
Liver, T cells

Phenotypes for genes affiliated with Portal Vein Thrombosis

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25MGI
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MGI Mouse Phenotypes related to portal vein thrombosis:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:00053979.1EPO, THPO, IFNAR2, PCNA
2immune system phenotypeMP:00053878.6PLAT, F2, F8, IFNAR2, SELP, REN
3cardiovascular system phenotypeMP:00053857.1ABCB7, PLAT, CRP, F2, F3, F5
4mortality/agingMP:00107685.5F5, F3, F2, ALB, PLAT, ABCB7
5homeostasis/metabolism phenotypeMP:00053764.8REN, F2, ALB, SST, CRP, PLAT

Publications for genes affiliated with Portal Vein Thrombosis

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35PubMed
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Articles related to portal vein thrombosis:

(show top 50)    (show all 56)
idTitleAuthorsYearAffiliating Genes
1Portal vein thrombosis treated using danaparoid sodiu m and antithrombin III. (20422871)Uchiyama T.... Nakajima A.2010SERPINC1
2Combined use of D-dimer and P-selectin for the diagno sis of splenic or portal vein thrombosis following splenectomy. (20079524)Wang L.... Wang L.X.2010SELP
3Portal vein thrombosis in Egyptian patients with live r cirrhosis: Role of methylenetetrahydrofolate reductase C677T gene mutation. (20374299)Gabr M.A.... El-Zamarani E.A.2010MTHFR
4Liver transplantation in end-stage liver disease wit h portal vein thrombosis (19595038)Wu G.... Cheng D.H.2009F2
5Portal vein thrombosis due to factor 2 leiden in the post-operative course of a laparoscopic sleeve gastrectomy for morbid obesity. (19830507)Berthet B.... Sastre B.2009TTF2
6Correlation of routinely used coagulation parameters and presence of portal vein thrombosis in patients with liver cirrhosis. (19619258)Weber A.... Schulte-Frohlinde E.2009F3
7Resolution of preoperative portal vein thrombosis aft er administration of antithrombin III in living donor liver transplantation: ca se report. (19917415)Imai H.... Uemoto S.2009SERPINC1
8Etiology and portal vein thrombosis in Budd-Chiari syndrome. (18473410)Uskudar O.... Sahin B.2008APOH
9Acute myocardial infarction, ischemic cerebrovascular disease and variceal bleeding due to portal vein thrombosis in a patient with hereditary thrombophilia. (18388507)Baran B.... Dolar E.2008F5
10The JAK2(V617F) tyrosine kinase mutation identifies clinically latent myeloproliferative disorders in patients presenting with hepatic or portal vein thrombosis. (19046316)Goulding C.... McNamara C.2008JAK2
11JAK2V617F Mutation in Patients with Portal Vein Thrombosis. (18343999)Bayraktar Y.... Balkanci F.2008JAK2
12Coagulation abnormalities in cirrhotic patients with portal vein thrombosis. (18257465)Amitrano L.... Ames P.R.2007F2
13Superior mesenteric and portal vein thrombosis in a polycythemia vera patient with JAK2 mutation (17695304)Araki N.... Niitsu Y.2007JAK2
14Idiopathic portal vein thrombosis and FVIII levels. (17011614)Akar N.2007F8
15High FVIII level is associated with idiopathic portal vein thrombosis in South India. (17524760)Koshy A.... Jeyakumari M.2007F8
16The etiologic distribution of thrombophilic factors i n chronic portal vein thrombosis. (17450038)Harmanci O.... Bayraktar Y.2007SERPINC1
17Prothrombin G20210A gene variant is not associated with idiopathic portal vein thrombosis in an area endemic for portal vein thrombosis. (16283309)Koshy A.... Jeyakumari M.2006F2
18Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India. (16877827)Koshy A.... Jeyakumari M.2006F5
19Increased plasma prothrombin concentration in cirrhotic patients with portal vein thrombosis and prothrombin G20210A mutation. (16493481)Amitrano L.... Balzano A.2006F2
20Factor V Leiden and prothrombin gene G20210A mutations are uncommon in portal vein thrombosis in India. (17090840)Sharma S.... Aggarwal R.2006F2, F5
21Mesenteric and portal vein thrombosis: treated with early initiation of anticoagulation. (15649730)Joh J.H.... Kim D.I.2005SERPINC1
22Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression. (16106266)Ota H.... Monden M.2005IFNAR2
23Thrombophilic gene mutations in cirrhotic patients with portal vein thrombosis. (15716659)Erkan O.... Uzunalimoglu O.2005F2, F5, MTHFR
24Mesenteric and portal vein thrombosis associated with hyperhomocysteinemia and heterozygosity for factor V Leiden mutation. (16437705)Famularo G.... Simone C.D.2005F5
25Extrahepatic portal vein thrombosis in children: etiology and long-term follow-up. (15087698)GA1rakan F.... Demir H.2004F5
26Portal vein thrombosis complicating islet transplanta tion in a recipient with the Factor V Leiden mutation. (15257060)Brennan D.C.... Shapiro J.2004F5
27Inherited prothrombotic defects in Budd-Chiari syndrome and portal vein thrombosis: a study from North India. (15198356)Bhattacharyya M.... Saxena R.2004SERPINC1, F5
28Prevalence of factor V Leiden mutation and other hereditary thrombophilic factors in Egyptian children with portal vein thrombosis: results of a single-center case-control study. (15309526)El-Karaksy H.... A-Kader H.2004SERPINC1, F5
29Portal vein thrombosis in children and adolescents: the low prevalence of hereditary thrombophilic disorders. (15359390)Pinto R.B.... Rohsig L.2004F2, F5, MTHFR
30Portal vein thrombosis associated with factor V Leid en mutation in a woman who underwent exchange transfusion at birth (12910230)Tchuenbou J.... Metman E.H.2003F5
31Chylous ascites caused by portal vein thrombosis treated with octreotide. (12974913)Leong R.W.... Jeffrey G.P.2003SST
32Thrombophilic disorders in children and adolescents with portal vein thrombosis (14502338)Pinto R.B.... Bandinelli E.2003SERPINC1, F5
33Combination chemotherapy for advanced hepatocellular carcinoma complicated by major portal vein thrombosis. (11868789)Kaneko S.... Kobayashi K.2002IFNA2
34Portal vein thrombosis after hematopoietic cell transplantation: frequency, treatment and outcome. (11896430)Kikuchi K.... McDonald G.B.2002SERPINC1
35Relationship between the proliferative activity of c ancer cells and microvessel density in portal vein thrombosis and transfer of h epatocellular carcinoma (12392620)Meng C.C.... Liu A.Z.2002PCNA
36Functional protein C and anti-cardiolipin antibody in children with portal vein thrombosis. (11305488)Yachha S.K.... Naik S.R.2001APOH
37Renal function, sodium and water homeostasis in patients with idiopathic extrahepatic portal vein thrombosis compared with normal healthy controls. (11236301)Rayner B.L.... Voigt M.2001REN
38The role of natural anticoagulant deficiencies and factor V Leiden in the development of idiopathic portal vein thrombosis. (10636214)Egesel T.... Bayraktar Y.2000SERPINC1, F5
39Deficiency of natural anticoagulant proteins C, S, and antithrombin in portal vein thrombosis: a secondary phenomenon? (10716684)Fisher N.C.... Elias E.2000SERPINC1
40Inherited coagulation disorders in cirrhotic patients with portal vein thrombosis. (10655256)Amitrano L.... Balzano A.2000F2, F5, MTHFR
41Combined therapy consisting of intraarterial cisplatin infusion and systemic interferon-alpha for hepatocellular carcinoma patients with major portal vein thrombosis or distant metastasis. (10813709)Chung Y.H.... Suh D.J.2000IFNA1
42Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study. (11001884)Janssen H.L.... Rosendaal F.R.2000SERPINC1, F5
43Frequent factor II G20210A mutation in idiopathic portal vein thrombosis. (9869612)Chamouard P.... Oudet P.1999F2, F5
44Refractory ascites due to portal vein thrombosis in liver cirrhosis--report of two cases. (9840147)Tanaka H.... Kawasaki H.1998ALB
45Prevalence of the factor V Leiden mutation in hepatic and portal vein thrombosis. (9245936)Mahmoud A.E.A.... Wilde J.T.1997F5
46Portal vein thrombosis in association with factor V Leiden mutation in a patient with hepatocellular carcinoma. (9212850)GA1rgey A.... GAPgA1A9 S.1997F5
47Portal vein thrombosis due to antithrombin III deficiency. A case report. (7486227)Yonemitsu Y.... Sugimachi K.1995SERPINC1
48A new hereditary cause of portal vein thrombosis: the abnormal resistance to activated protein C by the Arg 506-->Gln mutation of the gene of factor V (8522125)Levoir D.... Petite J.P.1995SERPINC1, F5
49Polycythaemia and portal vein thrombosis. (1296193)DrAcnou B.... Fauchet R.1992EPO
50The Sugiura procedure for patients with hemorrhagic portal hypertension secondary to extrahepatic portal vein thrombosis. (1866670)Orozco H.... Hernandez-Ortiz J.1991SERPINC1

Expression for genes affiliated with Portal Vein Thrombosis

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Portal Vein Thrombosis

Pathways for genes affiliated with Portal Vein Thrombosis

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36QIAGEN, 38Reactome, 10EMD Millipore, 41Thomson Reuters, 37R&D Systems, 20KEGG
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Pathways related to portal vein thrombosis according to GeneDecks:

(show all 15)
idPathwayScoreTop Affiliating Genes
1Intrinsic Prothrombin Activation Pathway3610.0F2, F5, F8, SERPINC1
2Extrinsic Prothrombin Activation Pathway3610.0F2, F3, F5, SERPINC1
3Common Pathway389.9SERPINC1, F5
4Blood Coagulation Cascade369.8F2, F3, F5, F8, SERPINC1
5Development Thrombopoetin signaling via JAK-STAT pathway109.6JAK2, CRP
6Development_Thrombopoetin signaling via JAK-STAT pathway419.4JAK2, CRP, THPO
7Immune response_IFN alpha/beta signaling pathway419.3IFNAR2, IFNA2, IFNA1
8Immune response IFN alpha/beta signaling pathway109.2IFNAR2, IFNA2, IFNA1
9Interferon Pathway369.1IFNAR2, IFNA2, IFNA1, JAK2
10Blood Coagulation Signaling Pathways379.1SERPINC1, PLAT, F2, F3, F5, F8
11Complement and coagulation cascades209.1PLAT, F2, F3, F5, F8, SERPINE1
12Measles209.1JAK2, IFNA1, IFNA2, IFNAR2
13Jak-STAT signaling pathway209.0JAK2, IFNA1, IFNA2, IFNAR2, EPO
14Selected targets of HNF1109.0CRP, ALB, F8, APOH
15JAK-STAT Pathway368.7EPO, THPO, F2, IFNAR2, IFNA2, IFNA1

Compounds for genes affiliated with Portal Vein Thrombosis

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32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
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Compounds related to portal vein thrombosis according to GeneDecks:

(show top 50)    (show all 315)
idCompoundScoreTop Affiliating Genes
1cyclophosphamide32 34 9 9 13.5F8, APOH
2hirudin32 10.5THPO, F5, SERPINC1
3clopidogrel32 34 9 18 9 14.4SERPINC1, CYP2C9
4glucose32 10.1IFNA2, THPO
5ximelagatran32 9 9 11.9CYP2C9, F2, SERPINC1
6polyethylene glycol32 9.9AFP, F8, IFNA2, SERPINC1
7ristocetin32 9.7PLAT, F2, F8, SERPINC1, SELP
8aprotinin32 9 9 11.6SERPINC1, F5, F2, SELP, PLAT
9spectrozyme32 9.6SERPINC1, F3, PLAT, F2, F5
10tranexamic acid32 9 9 11.6EPO, PLAT, F8, SERPINE1, SERPINC1
11coumarins32 9.6F3, APOH, F2, F5, VKORC1, CYP2C9
12kaolin32 9.5F3, F5, F8, APOH, F2
13bivalirudin32 9 9 11.4PLAT, F3, F5, SERPINC1, SELP, F2
14ancrod32 9.4SERPINE1, F5, PLAT, SERPINC1, F2
15argatroban32 9 9 11.4PLAT, F2, SELP, F3, SERPINC1, F5
16aspartate32 9.4F5, F8, SELP, PCNA, F2, ABCB7
17batroxobin32 9.4PLAT, F2, F5, SERPINE1, SELP
18acenocoumarol32 34 9 9 12.3VKORC1, CYP2C9, ALB, F2, F3, F5
19phenprocoumon32 34 9 9 12.3VKORC1, F3, F2, ALB, CYP2C9, SERPINC1
20hydroxyethyl starch32 9.2F2, SELP, F8, ALB, SERPINC1, F3
21ascorbic acid32 18 10.1PCNA, JAK2, IFNA2, EPO
22epsilon aminocaproic acid32 9.0F3, EPO, PLAT, SERPINE1, F2, SERPINC1
23protamine32 8.9PLAT, F2, F3, SERPINE1, SERPINC1, SELP
24ticlopidine32 9 9 10.8SERPINC1, APOH, F3, CYP2C9, PLAT, SELP
25heparin32 9 18 9 11.7AFP, THPO, TTF2, ABCB7, ALB, F2
26tirofiban32 9 9 10.6SERPINC1, PLAT, F3, F2, CRP, SELP
27epinephrine32 9 18 9 11.6REN, SELP, AFP, JAK2, F8, F5
28testosterone32 9 18 9 11.4EPO, ABCB7, SST, F5, MTHFR, SERPINC1
29estrogen32 8.4AFP, TTF2, PCNA, F2, F8, MTHFR
30dextran sulfate32 8.3JAK2, SELP, APOH, F5, F3, ALB
31desmopressin32 42 9 9 11.3SERPINC1, SELP, REN, SERPINE1, F8, F5
32valsartan32 42 9 9 11.2REN, SELP, SERPINE1, CYP2C9, CRP, ALB
33uric acid32 18 9.1ABCB7, AFP, SERPINE1, MTHFR, APOH, F5
34kininogen32 8.0PLAT, ALB, F2, F3, F5, APOH
35simvastatin32 34 42 9 18 9 12.9CYP2C9, F5, F2, CRP, PLAT, AFP
36vitamin b1232 7.8AFP, EPO, CRP, ALB, F5, APOH
37warfarin32 34 9 18 9 11.6SERPINC1, SELP, VKORC1, TTF2, PLAT, CYP2C9
38cyclosporin a32 42 8.4TTF2, MTHFR, PLAT, JAK2, IFNA1, CYP2C9
39prostacyclin32 7.3REN, THPO, PLAT, CRP, CYP2C9, F3
40fibrinogen32 7.2F3, F5, APOH, SERPINE1, SERPINC1, SELP
41losartan32 34 9 9 10.2ALB, REN, PCNA, SELP, SERPINE1, CYP2C9
42homocysteine32 18 8.2ALB, F2, F3, F5, F8, APOH
43dexamethasone32 42 34 9 9 11.0CYP2C9, F8, REN, IFNA1, PCNA, SERPINE1
44lactate32 6.8PCNA, SELP, F5, F8, AFP, EPO
45creatinine32 6.6AFP, EPO, REN, THPO, TTF2, ABCB7
46cholesterol32 9 18 9 9.3CRP, CYP2C9, ALB, F8, F5, APOH
47aspirin32 34 18 8.2SERPINE1, SERPINC1, SELP, PCNA, MTHFR, JAK2
48retinoic acid32 42 18 8.2IFNA2, PCNA, IFNA1, SELP, SERPINE1, IFNAR2
49alanine32 5.6F5, F3, F2, ALB, CRP, ABCB7
50vegf32 5.1CRP, AFP, EPO, TTF2, IFNA1, APOH

GO Terms for genes affiliated with Portal Vein Thrombosis

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12Gene Ontology
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Cellular components related to portal vein thrombosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.2SERPINE1, APOH, F3, PLAT
2platelet alpha granule lumenGO:0310939.0ALB, F5, F8, SERPINE1
3extracellular regionGO:0055766.3EPO, PLAT, CRP, SST, ALB, F2
4extracellular spaceGO:0056154.9REN, AFP, EPO, THPO, PLAT, CRP

Biological processes related to portal vein thrombosis according to GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1blood circulationGO:00801510.1EPO
2blood coagulation, intrinsic pathwayGO:00759710.0F2, F8, APOH
3negative regulation of fibrinolysisGO:05191810.0F2, APOH, SERPINE1
4positive regulation of blood coagulationGO:0301949.9F2, APOH, SERPINE1
5positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.8SELP, JAK2, F2
6fibrinolysisGO:0427309.7SERPINE1, F2, PLAT
7plasminogen activationGO:0316399.5APOH, PLAT
8response to lipopolysaccharideGO:0324969.5EPO, THPO, F3, JAK2, SELP
9acute-phase responseGO:0069539.4F8, F2, CRP
10platelet degranulationGO:0025769.3ALB, F5, F8, SERPINE1, SELP
11cell surface receptor signaling pathwayGO:0071669.2IFNA2, IFNAR2, F2, SST
12platelet activationGO:0301689.0THPO, ALB, F2, F5, F8, SERPINE1
13blood coagulationGO:0075967.3SELP, THPO, PLAT, ALB, F2, F3

Molecular functions related to portal vein thrombosis according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.7SERPINC1, SERPINE1, F3
2eukaryotic cell surface bindingGO:0434999.4SELP, APOH, EPO
3protein bindingGO:0055154.8PCNA, EPO, TTF2, PLAT, CRP, ALB

Sources for Portal Vein Thrombosis

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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