MCID: PRT018
MIFTS: 55

Portal Vein Thrombosis malady

Cardiovascular diseases, Liver diseases, Rare diseases, Blood diseases categories
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Summaries for Portal Vein Thrombosis

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Wikipedia:65 Portal vein thrombosis is a form of venous thrombosis affecting the hepatic portal vein, which can lead... more...

MalaCards based summary: Portal Vein Thrombosis, also known as portal hypertension due to infrahepatic block, is related to hepatitis and portal hypertension. An important gene associated with Portal Vein Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Integrin alphaIIb beta3 signaling. The compounds certoparin and deae-sephadex a-50 have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and spleen, and related mouse phenotypes are cardiovascular system and embryogenesis.

Disease Ontology:8 A vein disease that is characterized by a blood clot that forms within the hepatic portal vein.

Aliases & Classifications for Portal Vein Thrombosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
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Portal Vein Thrombosis, Aliases & Descriptions:

Name: Portal Vein Thrombosis 8 10 44 48 62
 
Portal Hypertension Due to Infrahepatic Block 48


Classifications:

Orphanet: 48 
Rare hepatic diseases


Characteristics (Orphanet epidemiological data):

48
portal vein thrombosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:11695
ICD9CM27 452
NCIt39 C78565
SNOMED-CT57 17920008, 155455003
ICD10 via Orphanet26 I81
UMLS via Orphanet63 C0155773
ICD1025 I81

Related Diseases for Portal Vein Thrombosis

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Diseases related to Portal Vein Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.5F2, THPO
2portal hypertension31.3THPO, F2
3eclampsia31.0SERPINC1
4purpura30.9SERPINC1, THPO
5protein c deficiency30.9F5, F2, SERPINC1
6hepatitis b30.8ABCB7, F2
7liver cirrhosis30.8ABCB7, F2, SERPINC1, THPO
8antithrombin iii deficiency30.8SERPINC1, F2, F5
9hypersplenism30.7THPO, F2
10homocystinuria30.7F5, SERPINC1
11lupus erythematosus30.6F2, F5, SERPINC1
12hyperhomocysteinemia30.6SERPINC1, F2, F8, F5
13thrombophilia30.6F5, F8, SERPINC1, F2
14protein s deficiency30.5F2, SERPINC1, F8, F5
15pulmonary embolism30.4F2, F5, SERPINC1
16thrombocytosis30.4SERPINC1, THPO, F2
17hepatitis c30.4ABCB7, F2, THPO
18acute myocardial infarction30.3SERPINC1, ABCB7
19sepsis30.3F2, SERPINC1, F5
20antiphospholipid syndrome30.3SERPINC1, F8, F5, F2
21thromboembolism30.3F8, F5, F2, SERPINC1
22myocardial infarction30.2SERPINC1, F5, ABCB7, F8
23pre-eclampsia30.1F2, SERPINC1, F8, F5
24cerebrovascular disease30.1F2, SERPINC1, F8, F5
25liver cancer30.0F2, ABCB7, F8
26disseminated intravascular coagulation29.6F5, SERPINC1, THPO, F2, F8
27hepatocellular carcinoma11.1
28hypertension10.8
29pancreatitis10.8
30portal hypertension due to infrahepatic block10.7
31ulcerative colitis10.6
32colitis10.6
33liver disease10.6
34tuberculosis10.6
35cholecystitis10.5
36sneddon syndrome10.5SERPINC1
37central retinal vein occlusion10.5F5
38thrombophlebitis10.5F8
39obesity10.5
40thalassemia10.5
41acute pancreatitis10.5
42biliary atresia10.5
43abdominal tuberculosis10.5
44hepatic encephalopathy10.5
45schistosomiasis10.5
46chylous ascites10.5
47cytomegalovirus infection10.5
48inflammatory bowel disease10.5
49branch retinal artery occlusion10.5F5
50factor xii deficiency10.5F5

Graphical network of the top 20 diseases related to Portal Vein Thrombosis:



Diseases related to portal vein thrombosis

Symptoms for Portal Vein Thrombosis

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Drugs & Therapeutics for Portal Vein Thrombosis

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Drug clinical trials:

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Search NIH Clinical Center for Portal Vein Thrombosis

Genetic Tests for Portal Vein Thrombosis

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Anatomical Context for Portal Vein Thrombosis

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MalaCards organs/tissues related to Portal Vein Thrombosis:

32
Liver, Colon, Spleen, Pancreas, Myeloid, Whole blood, Lymph node, Neutrophil

Animal Models for Portal Vein Thrombosis or affiliated genes

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MGI Mouse Phenotypes related to Portal Vein Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5F2, ABCB7, SERPINC1, F5
2MP:00053808.4ABCB7, SERPINC1, F5, F2
3MP:00053767.9F5, F2, ABCB7, SERPINC1, F8
4MP:00107687.6F2, ABCB7, SERPINC1, F8, F5

Publications for Portal Vein Thrombosis

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Articles related to Portal Vein Thrombosis:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Cirrhosis of liver and portal vein thrombosis - a review article. (25178622)
2014
2
Natural course of nonmalignant partial portal vein thrombosis in cirrhotic patients. (25253363)
2014
3
Chronic idiopathic non-cirrhotic portal vein thrombosis treated with a mesocaval shunt procedure and anticoagulation. (25114412)
2014
4
Portal Vein Thrombosis After Hepatectomy. (24407940)
2014
5
Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib. (23914915)
2013
6
Impact of portal vein thrombosis on the efficacy of endoscopic variceal band ligation. (24084343)
2013
7
Portomesenteric shunt for liver transplantation and complete portal vein thrombosis. (24247901)
2013
8
Portal Vein Thrombosis: A Clinician-Oriented and Practical Review. (23364162)
2013
9
Successful treatment of acute portal vein thrombosis with rivaroxaban. (23846289)
2013
10
Does decreased fibrinolysis have a role to play in the development of non-neoplastic portal vein thrombosis in patients with hepatic cirrhosis? (23504244)
2013
11
Implementation of laparoscopic splenectomy in children and the incidence of portal vein thrombosis diagnosed by ultrasonography. (24210199)
2013
12
Orthotopic liver transplantation in patients with portal vein thrombosis in the absence of hepatocellular carcinoma. (23146508)
2012
13
Optimal length of anticoagulant therapy in cirrhotic patients with portal vein thrombosis. (22387253)
2012
14
Obesity is an independent risk factor for pre-transplant portal vein thrombosis in liver recipients. (22909075)
2012
15
Huge inflammatory pseudotumor of the spleen with postoperative portal vein thrombosis: report of a case. (22160356)
2012
16
Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis. (22819864)
2012
17
Portal vein thrombosis in inflammatory bowel diseases: a single-center case series. (22405175)
2012
18
The inferior mesenteric vein to the left gonadal vein shunt for gastroesophageal varices and extrahepatic portal vein thrombosis after living donor liver transplantation: a case report. (22410077)
2012
19
Evaluation of portal vein thrombosis in liver graft ten years after liver transplantation due to budd-Chiari syndrome using Doppler ultrasound. (23322979)
2012
20
An early single-center experience of portal vein thrombosis in living donor liver transplantation: clinical feature, management and outcome. (22066098)
2011
21
Portal vein thrombosis and budd-Chiari syndrome. (22054734)
2011
22
Caval inflow to the graft for liver transplantation in patients with diffuse portal vein thrombosis: a 12-year experience. (21869678)
2011
23
Case of asymptomatic portal vein thrombosis after cesarean delivery. (21599802)
2011
24
A rare cause of portal vein thrombosis in a previously healthy young man with acute hepatitis. (21493127)
2011
25
Portal vein thrombosis in biliary atresia patients after living donor liver transplantation. (20570300)
2011
26
Extrahepatic portal vein thrombosis after umbilical catheterization: is it a good choice for Rex shunt? (21238670)
2011
27
Correlation of splenectomy with portal vein thrombosis in beta-thalassemia major. (22355997)
2011
28
Chemoembolization for unresectable hepatocellular carcinoma in patients with or without portal vein thrombosis. (21443089)
2010
29
Transjugular intrahepatic portosystemic shunt with thrombectomy for the treatment of portal vein thrombosis after liver transplantation. (19242796)
2010
30
Posttransplant bilioportal fistula with portal vein thrombosis: a case report. (21094871)
2010
31
VKORC1 and CYP2C9 genetic polymorphisms in hepatic or portal vein thrombosis. (20434758)
2010
32
Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study. (19821530)
2010
33
Portal vein thrombosis and liver transplantation: long term. (20304176)
2010
34
Liver transplantation in end-stage liver disease with portal vein thrombosis]. (19595038)
2009
35
Portal vein thrombosis and budd-Chiari syndrome. (19150317)
2009
36
Portal vein thrombosis in the district general hospital: management and clinical outcomes. (19262399)
2009
37
Pancreatic laceration and portal vein thrombosis in blunt trauma abdomen. (20011472)
2008
38
Portal vein thrombosis: CT features. (17694406)
2008
39
Management of portal vein thrombosis. (21960890)
2008
40
Late onset portal vein thrombosis and its risk factors. (18705318)
2008
41
Superior mesenteric and portal vein thrombosis caused by congenital antithrombin III deficiency: report of a case. (17387563)
2007
42
High FVIII level is associated with idiopathic portal vein thrombosis in South India. (17524760)
2007
43
Experimental hepatic radiofrequency ablation using wet electrodes: electrode-to-vessel distance is a significant predictor for delayed portal vein thrombosis. (16541225)
2006
44
Acute idiopathic portal vein thrombosis in a child: a case report and literature review. (16378832)
2006
45
Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy. (16557541)
2006
46
Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India. (16877827)
2006
47
Extrahepatic portal vein thrombosis in children: etiology and long-term follow-up. (15087698)
2004
48
Portal vein thrombosis after variceal endoscopic sclerotherapy in cirrhotic patients: role of genetic thrombophilia. (12170404)
2002
49
Portal vein thrombosis associated with hilar bile duct carcinoma and liver abscess. (11269004)
2001
50
Portal vein thrombosis caused by protein C and protein S deficiency associated with cytomegalovirus infection. (7699538)
1995

Variations for Portal Vein Thrombosis

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Expression for genes affiliated with Portal Vein Thrombosis

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Expression patterns in normal tissues for genes affiliated with Portal Vein Thrombosis

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Pathways for genes affiliated with Portal Vein Thrombosis

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Compounds for genes affiliated with Portal Vein Thrombosis

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Compounds related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1certoparin449.7F2, SERPINC1
2deae-sephadex a-50449.6F2, F8
3polybrene449.5SERPINC1, F2
4inogatran449.5F2, SERPINC1, F5
5hirugen449.5F2, SERPINC1, F5
6ecarin449.5F5, SERPINC1, F2
7spectrozyme449.5SERPINC1, F2, F5
8danaparoid449.5F5, SERPINC1, F2
9ximelagatran44 1110.5F5, F2, SERPINC1
10ancrod449.5F2, F5, SERPINC1
11heparinoids449.5SERPINC1, F5, F2
12fondaparinux449.5F5, F2, SERPINC1
13bivalirudin44 1110.5F5, SERPINC1, F2
14desogestrel44 1110.5F5, SERPINC1, F2
15argatroban44 1110.5SERPINC1, F5, F2
16protamine sulfate449.5F2, SERPINC1, F5
17gestodene44 1110.4F2, SERPINC1, F5
18levonorgestrel44 61 28 1112.4SERPINC1, F5, F2
19hydroxyethyl starch449.4F8, SERPINC1, F2
20coumarin44 2 50 2412.4SERPINC1, F5, F2
21kaolin449.4F2, F5, F8
22tranexamic acid44 1110.4F8, F2, SERPINC1
23protamine449.3F5, SERPINC1, F2
24dermatan sulfate449.3F2, SERPINC1, F5
25kininogen449.3SERPINC1, F2, F5
26cardiolipin44 1110.3F2, F5, F8
27phosphatidylethanolamine44 1110.3F5, F8, F2
28rfviii449.2F8, F5
29aprotinin44 1110.2SERPINC1, F2, F5
30acetaminophen44 2 50 24 1113.1F8, F2, F5
31progestin449.1F5, F8, SERPINC1
32ristocetin449.0F5, F8, SERPINC1, F2
33desmopressin44 61 28 1112.0SERPINC1, F8, F5, F2
34warfarin44 50 24 1112.0SERPINC1, F5, F8, F2
35homocysteine44 249.9F5, F8, SERPINC1, F2
36citrate448.9F2, SERPINC1, F8, F5
37prostacyclin448.6F5, SERPINC1, F8, THPO
38tamoxifen44 50 28 1111.5THPO, F5, SERPINC1, F2
39polysaccharide448.5THPO, F8, SERPINC1, F5
40epinephrine44 24 1110.5F2, F5, THPO, F8
41aspartate448.3F5, F8, ABCB7, F2
42hirudin448.2F5, F2, THPO, SERPINC1, F8
43polyethylene glycol448.2THPO, SERPINC1, F5, F2, F8
44aspirin44 50 28 2411.2F2, SERPINC1, F8, THPO, F5
45estrogen448.0SERPINC1, F8, F2, THPO, F5
46lactate447.9ABCB7, F2, THPO, F5, F8
47fibrinogen447.6F8, SERPINC1, ABCB7, F2, THPO, F5
48creatinine447.6F2, F5, F8, SERPINC1, THPO, ABCB7
49heparin44 28 24 1110.6F5, THPO, F8, SERPINC1, ABCB7, F2
50alanine447.5F2, ABCB7, THPO, F8, F5, SERPINC1

GO Terms for genes affiliated with Portal Vein Thrombosis

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Cellular components related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.5SERPINC1, F2
2platelet alpha granule lumenGO:0310939.4F8, F5
3extracellular regionGO:0055768.3F5, F2, SERPINC1, F8
4extracellular spaceGO:0056157.7SERPINC1, F2, F5, F8, THPO

Biological processes related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:0075979.4F8, F2
2acute-phase responseGO:0069539.3F2, F8
3platelet degranulationGO:0025769.2F8, F5
4positive regulation of protein phosphorylationGO:0019349.1F2, THPO
5platelet activationGO:0301688.2THPO, F8, F5, F2
6blood coagulationGO:0075967.9SERPINC1, F2, THPO, F5, F8

Molecular functions related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.5F5, F8
2serine-type endopeptidase activityGO:0042528.7F5, F8, F2

Products for genes affiliated with Portal Vein Thrombosis

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Sources for Portal Vein Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet