MCID: PRT018
MIFTS: 57

Portal Vein Thrombosis malady

Cardiovascular diseases, Liver diseases, Blood diseases categories

Summaries for Portal Vein Thrombosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Portal vein thrombosis is a form of venous thrombosis affecting the hepatic portal vein, which can lead... more...

MalaCards: Portal Vein Thrombosis, also known as portal hypertension due to infrahepatic block, is related to hepatocellular carcinoma and hepatic vein thrombosis. An important gene associated with Portal Vein Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are TGF-Beta Pathway and PTM: gamma carboxylation, hypusine formation and arylsulfatase activation. The compounds acetaminophen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and spleen, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Portal Vein Thrombosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Liver diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

48
portal vein thrombosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

portal vein thrombosis 8 10 44 48 60
portal hypertension due to infrahepatic block 48


External Ids:

Disease Ontology8 DOID:11695
ICD9CM27 452
NCIt39 C78565
ICD10 via Orphanet26 I81
SNOMED-CT56 155455003, 17920008
SNOMED-CT via Orphanet57 17920008
UMLS via Orphanet61 C0155773
ICD1025 I81

Related Diseases for Portal Vein Thrombosis

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17GeneCards, 18GeneDecks
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Diseases related to Portal Vein Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1hepatocellular carcinoma31.5IFNAR2, IFNA2, F8, AFP, ABCB7, F2
2hepatic vein thrombosis31.4PROS1
3hepatitis31.4SELP, THPO, F2, AFP, IFNA2
4liver cirrhosis31.3AFP, IFNA2, SST, REN, ABCB7, F2
5portal hypertension31.1THPO, F2, SST
6hypertension31.1F5, MTHFR, PROS1, REN, F2
7pancreatitis31.1SELP, SST
8hepatitis a30.9F2, F8
9protein c deficiency30.9APOH, F5, MTHFR, PROS1, F2, SERPINC1
10protein s deficiency30.8APOH, F8, F5, MTHFR, PROS1, F2
11acute pancreatitis30.8SST, ABCB7
12hyperhomocysteinemia30.7APOH, F8, F5, MTHFR, PROS1, F2
13purpura30.7THPO, SERPINC1
14thrombophilia30.7F5, MTHFR, PROS1, F2, SELP, SERPINC1
15antiphospholipid syndrome30.7SERPINC1, SELP, F2, PROS1, APOH, F8
16obesity30.6TTF2, ABCB7, JAK2
17hepatitis b30.6F2, ABCB7, AFP, IFNA2
18hepatitis c30.6IFNAR2, IFNA2, AFP, ABCB7, F2, THPO
19factor v deficiency30.4F8, F5, F2
20lupus erythematosus30.4APOH, IFNA2
21prothrombin deficiency30.4APOH, F5, F2, SERPINC1
22hypersplenism30.4F2, THPO
23antithrombin iii deficiency30.4APOH, F5, MTHFR, PROS1, F2, SERPINC1
24thrombocytosis30.4SERPINC1, IFNA2, JAK2, F2, THPO, SELP
25myocardial infarction30.4F5, MTHFR, CYP2C9, REN, ABCB7, SELP
26nephrotic syndrome30.2SERPINC1
27pre-eclampsia30.2AFP
28sickle cell disease30.2SELP
29polycythemia30.2THPO, JAK2
30eclampsia30.2SERPINC1, MTHFR
31peritonitis30.2F2, SELP
32ischemia30.2SELP, JAK2
33acute myocardial infarction30.2ABCB7, SELP, SERPINC1
34essential hypertension30.2SELP, REN
35sarcoma30.2F8, JAK2, THPO
36homocystinuria30.2SERPINC1, MTHFR, F5
37myeloid leukemia30.2JAK2, TTF2, THPO
38cerebrovascular disease30.2APOH, MTHFR, SELP
39colon cancer30.2TTF2, MTHFR, JAK2
40disseminated intravascular coagulation30.2F8, F5, F2, THPO, SERPINC1
41polycythemia vera30.2IFNA2, JAK2, THPO, SELP
42viral hepatitis30.2IFNA2, F8, AFP, ABCB7, F2
43systemic mastocytosis30.2IFNA2, JAK2
44leukemia30.2IFNA2, F8, JAK2, MTHFR, THPO
45chronic myeloid leukemia30.2IFNA2, JAK2, THPO, SELP
46pulmonary embolism30.2APOH, F5, MTHFR, PROS1, F2, SERPINC1
47adenocarcinoma30.2IFNAR2, JAK2, PROS1, AFP, SST, TTF2
48vein disease10.9
49liver disease10.6
50portal hypertension due to infrahepatic block10.6

Graphical network of the top 20 diseases related to Portal Vein Thrombosis:



Diseases related to portal vein thrombosis

Clinical Features for Portal Vein Thrombosis

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Drugs & Therapeutics for Portal Vein Thrombosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Portal Vein Thrombosis

Drug clinical trials:

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Search CenterWatch for Portal Vein Thrombosis

Genetic Tests for Portal Vein Thrombosis

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Anatomical Context for Portal Vein Thrombosis

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32MalaCards
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MalaCards organs/tissues related to Portal Vein Thrombosis:

32
Liver, Colon, Spleen, Pancreas, Whole blood, Lymph node, Breast, Myeloid, Endothelial

Animal Models for Portal Vein Thrombosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Portal Vein Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.9F8, JAK2, SST, REN, F2, THPO
2MP:00053978.6IFNAR2, F8, JAK2, PROS1, REN, F2
3MP:00107688.1IFNAR2, APOH, F8, JAK2, F5, MTHFR
4MP:00053767.8SERPINC1, IFNAR2, APOH, F8, JAK2, F5

Publications for Portal Vein Thrombosis

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Sources:
50PubMed
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Articles related to Portal Vein Thrombosis:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Successful treatment of acute portal vein thrombosis with rivaroxaban. (23846289)
2013
2
Direct portal vein thrombosis visualization with t2*--weighted magnetic resonance imaging. (24046533)
2013
3
Portal vein thrombosis as a complication of laparoscopic sleeve gastrectomy. (24316998)
2013
4
Management and long-term consequences of portal vein thrombosis after liver transplantation in children. (23495080)
2013
5
Using ALPPS to induce rapid liver hypertrophy in a patient with hepatic fibrosis and portal vein thrombosis. (22996934)
2013
6
Q: is anticoagulation appropriate for all patients with portal vein thrombosis? (24085803)
2013
7
Portal Vein Thrombosis Secondary to Embolization of Superior Mesenteric Arteriovenous Fistula. (24200133)
2013
8
Opioid withdrawal syndrome after treatment with low-dose extended-release oxycodone and naloxone in a gastric cancer patient with portal vein thrombosis. (23680581)
2013
9
Portal vein thrombosis: should anticoagulation be used? (23314804)
2013
10
Impact of anticoagulation on outcomes in acute non-cirrhotic and non- malignant portal vein thrombosis: a retrospective observational study. (23858545)
2013
11
Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis. (22819864)
2012
12
Emergency anticoagulation treatment for cirrhosis patients with portal vein thrombosis and acute variceal bleeding. (22472055)
2012
13
Portal vein thrombosis in a patient with Turner's syndrome: a case report. (22560822)
2012
14
Portal vein thrombosis in 33 dogs: 1998-2011. (22369249)
2012
15
Pancreatic stent migration into the portal vein causing portal vein thrombosis: a rare complication of a prophylactic pancreatic stent. (23127537)
2012
16
A large portal vein: a rare finding of recent portal vein thrombosis. (21326856)
2011
17
Posttransplant bilioportal fistula with portal vein thrombosis: a case report. (21094871)
2010
18
Portal vein thrombosis and liver transplantation: long term. (20304176)
2010
19
Portal vein thrombosis postlaparoscopic splenectomy presenting with infarction of gut: review of risk factors, investigations, postoperative surveillance, and management. (20729701)
2010
20
The epidemiology and clinical features of portal vein thrombosis: a multicentre study. (21039677)
2010
21
Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosis. (19730112)
2010
22
Treatment of hepatocellular carcinoma with portal vein thrombosis by sorafenib combined with hepatic arterial infusion chemotherapy. (20981227)
2010
23
Portal vein thrombosis and budd-Chiari syndrome. (19150317)
2009
24
Portal vein thrombosis in a patient with hepatitis C virus-related cirrhosis complicated with antiphospholipid syndrome. (19184031)
2009
25
Portal vein thrombosis following laparoscopic total mesorectal excision: case report. (18545873)
2008
26
(18)F-FDG PET/CT for discrimination between tumor extension and blood thrombus in pancreatic adenocarcinoma associated with portal vein thrombosis. (18208781)
2008
27
Portal vein thrombosis after laparoscopic splenectomy: the size of the risk. (19036731)
2008
28
JAK2V617F mutation in patients with portal vein thrombosis. (18343999)
2008
29
Enhancing and expansile portal vein thrombosis: value in the diagnosis of hepatocellular carcinoma in patients with multiple hepatic lesions. (17449777)
2007
30
Hepatic arterial infusion chemotherapy with epirubicin in patients with advanced hepatocellular carcinoma and portal vein tumor thrombosis. (18097170)
2007
31
The etiologic distribution of thrombophilic factors in chronic portal vein thrombosis. (17450038)
2007
32
Factor V Leiden and prothrombin gene G20210A mutations are uncommon in portal vein thrombosis in India. (17090840)
2006
33
Portal, splenic, and superior mesenteric vein thrombosis in a patient with latent essential thrombocythemia and hyperhomocysteinemia. (16633126)
2006
34
Mesenterico left portal bypass for variceal bleeding owing to extrahepatic portal hypertension caused by portal vein thrombosis. (16818059)
2006
35
Prognostic index for patients with hepatocellular carcinoma combined with tumor thrombosis in the major portal vein. (16500247)
2006
36
Portal vein thrombosis following a primary cytomegalovirus infection in an immunocompetent adult. (16543982)
2006
37
Extensive portal vein thrombosis related to abdominal trauma. (16565670)
2006
38
Liver transplantation in recipients with portal vein thrombosis: experience of a single transplant center. (15848641)
2005
39
Fatty liver caused by portal vein thrombosis after living donor liver transplantation: a case report. (16080920)
2005
40
Imaging and radiological interventions of portal vein thrombosis. (16136689)
2005
41
Portal vein thrombosis. (16286254)
2005
42
Portal vein thrombosis (PVT): a study of 20 non-cirrhotic cases. (16106327)
2005
43
Inherited prothrombotic defects in Budd-Chiari syndrome and portal vein thrombosis: a study from North India. (15198356)
2004
44
Mesenteric adenitis and portal vein thrombosis due to Fusobacterium nucleatum. (15371934)
2004
45
Simultaneous hepatic artery and portal vein thrombosis after living donor liver transplantation. (15686701)
2004
46
Anticardiolipin antibodies in chronic hepatitis B and chronic hepatitis D infection, and hepatitis B-related hepatocellular carcinoma. Relationship with portal vein thrombosis. (12811301)
2003
47
Portal vein thrombosis complicating neonatal hepatic abscess. (14581740)
2003
48
Functional protein C and anti-cardiolipin antibody in children with portal vein thrombosis. (11305488)
2001
49
Portal vein thrombosis in association with factor V Leiden mutation in a patient with hepatocellular carcinoma. (9212850)
1997
50
Portal vein thrombosis caused by protein C and protein S deficiency associated with cytomegalovirus infection. (7699538)
1995

Genetic Variations for Portal Vein Thrombosis

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Expression for genes affiliated with Portal Vein Thrombosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Portal Vein Thrombosis

Search GEO for disease gene expression data for Portal Vein Thrombosis.

Pathways for genes affiliated with Portal Vein Thrombosis

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Sources:
51QIAGEN, 53Reactome, 49PharmGKB, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2THPO, F2
29.9F2, PROS1, VKORC1
3
Hide members
9.9F2, PROS1, VKORC1
49.9JAK2, IFNA2, IFNAR2
59.9PROS1, F2, SELP
6
Hide members
9.8F2, THPO, SELP, SERPINC1
7
Hide members
9.8F5, PROS1, F2, SERPINC1
8
Hide members
9.7F8, F5, PROS1, SELP
9
Hide members
9.7F8, F5, PROS1, F2, SERPINC1
10
Hide members
9.7F8, F5, PROS1, F2, SERPINC1
11
Hide members
9.7SERPINC1, F2, PROS1, F5, F8
12
Hide members
9.5IFNA2, F8, JAK2, F5, PROS1

Compounds for genes affiliated with Portal Vein Thrombosis

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Sources:
44Novoseek, 2BitterDB, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1acetaminophen44 2 49 11 2414.4CYP2C9
2estrogen4410.4THPO, F8, APOH
3coumarins4410.3CYP2C9, VKORC1, APOH
4ximelagatran44 1111.2F5, CYP2C9, F2, SERPINC1
5kaolin4410.2F2, F8, F5, APOH
6inogatran4410.2F5, F2, SERPINC1
7bivalirudin44 1111.2SERPINC1, SELP, F2, F5
8acenocoumarol44 49 1112.2F2, F5, CYP2C9, VKORC1
9argatroban44 1111.2SELP, SERPINC1, F2, F5
10hydroxyethyl starch4410.1F2, F8, SERPINC1, SELP
11phenprocoumon44 49 1112.1SERPINC1, VKORC1, F2, CYP2C9
12Drotrecogin alfa1110.1F5, F8, PROS1, F2
13ristocetin4410.1F5, F8, SELP, SERPINC1, F2
14aspartate4410.1F8, JAK2, AFP, ABCB7, F2
15hirugen4410.1F5, SERPINC1, F2
16coumarin44 2 49 2413.1VKORC1, F5, CYP2C9, SERPINC1, F2
17uric acid44 2411.1ABCB7, AFP, F5, APOH, TTF2
18dextran sulfate4410.0F5, JAK2, APOH, SELP
19gamma-carboxyglutamic acid4410.0F5, VKORC1, PROS1, F2
20hirudin4410.0THPO, SERPINC1, SELP, F2, F5, F8
21ticlopidine44 1111.0SELP, APOH, SERPINC1, CYP2C9
22desmopressin44 59 28 1112.9F5, F2, SELP, SERPINC1, F8, REN
23dexamethasone44 49 28 1112.9REN, CYP2C9, PROS1, F8, AFP
24warfarin44 49 11 2412.8SELP, SERPINC1, TTF2, APOH, VKORC1, CYP2C9
25kininogen449.8SERPINC1, F2, REN, F5, APOH, SELP
26polyethylene glycol449.8F8, F5, IFNA2, AFP, F2, THPO
27sialic acid449.7AFP, APOH, ABCB7, F8, SELP, THPO
28homocysteine44 2410.7APOH, SELP, F5, F8, SERPINC1, F2
29carboplatin44 49 1111.6MTHFR, IFNA2, AFP, SST, THPO
30glucose449.6TTF2, CYP2C9, PROS1, APOH, IFNA2, REN
31vitamin-e449.5PROS1, ABCB7, F5, JAK2, IFNA2
32diltiazem44 28 1111.5REN, CYP2C9, SERPINC1, F2
335fluorouracil449.4THPO, CYP2C9, SST, MTHFR, IFNA2, IFNAR2
34cyclophosphamide44 49 1111.4F8, MTHFR, F5, IFNA2, APOH, AFP
35lactate449.4ABCB7, F2, F5, AFP, F8, APOH
36progesterone44 59 28 11 2413.3F8, IFNA2, F5, AFP, CYP2C9, ABCB7
37heparin44 28 11 2412.3THPO, TTF2, ABCB7, AFP, PROS1, MTHFR
38prostacyclin449.2SELP, THPO, APOH, F8, F5, PROS1
39fibrinogen449.2APOH, F8, F5, AFP, ABCB7, F2
40cyclosporin a44 28 5911.1JAK2, TTF2, SELP, F8, MTHFR, CYP2C9
41nitric oxide44 11 2411.1THPO, CYP2C9, F5, JAK2, APOH, F8
42testosterone44 59 11 2412.1AFP, ABCB7, PROS1, MTHFR, SST, F5
43aspirin44 49 28 2412.1JAK2, F5, MTHFR, CYP2C9, F2, TTF2
44alanine448.9SERPINC1, ABCB7, THPO, TTF2, IFNAR2, F2
45retinoic acid44 249.9MTHFR, AFP, IFNA2, SST, CYP2C9, THPO
46epinephrine44 11 2410.9F8, SELP, JAK2, F5, AFP, SST
47steroid448.8JAK2, CYP2C9, AFP, PROS1, F5, F8
48cholesterol44 28 11 2411.7JAK2, APOH, F8, F5, SELP, TTF2
49creatinine448.7SERPINC1, SELP, THPO, TTF2, F2, ABCB7
50vegf448.5SERPINC1, SELP, F5, TTF2, REN, SST

GO Terms for genes affiliated with Portal Vein Thrombosis

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Sources:
16Gene Ontology
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Cellular components related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.9PROS1, F5, F8
2extracellular regionGO:0055768.5IFNAR2, IFNA2, F8, F5, PROS1, SST
3extracellular spaceGO:0056158.2SERPINC1, IFNAR2, IFNA2, APOH, F8, F5

Biological processes related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:03019410.2F2, APOH
2blood coagulation, intrinsic pathwayGO:00759710.1F2, F8, APOH
3peptidyl-glutamic acid carboxylationGO:01718710.1F2, PROS1, VKORC1
4positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.9JAK2, F2, SELP
5platelet degranulationGO:0025769.9F8, F5, PROS1, SELP
6negative regulation of fibrinolysisGO:0519189.9F2, APOH
7cell surface receptor signaling pathwayGO:0071669.7IFNAR2, IFNA2, SST, F2
8platelet activationGO:0301689.6F8, F5, PROS1, F2, THPO, SELP
9cellular protein metabolic processGO:0442679.4RPL36, VKORC1, PROS1, REN, F2
10blood coagulationGO:0075969.1SERPINC1, IFNA2, F8, JAK2, F5, PROS1

Products for genes affiliated with Portal Vein Thrombosis

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  • Antibodies
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Sources for Portal Vein Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet