MCID: PRT018
MIFTS: 47

Portal Vein Thrombosis malady

Cardiovascular diseases, Liver diseases, Rare diseases, Blood diseases categories

Summaries for Portal Vein Thrombosis

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Wikipedia:63 Portal vein thrombosis, previously known as Cauchois?Eppinger?Frugoni syndrome, is a form of venous... more...

MalaCards based summary: Portal Vein Thrombosis, also known as portal hypertension due to infrahepatic block, is related to budd-chiari syndrome and hepatitis. An important gene associated with Portal Vein Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Integrin alphaIIb beta3 signaling. The compounds certoparin and deae-sephadex a-50 have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and spleen, and related mouse phenotypes are cardiovascular system and embryogenesis.

Disease Ontology:9 A vein disease that is characterized by a blood clot that forms within the hepatic portal vein.

Aliases & Classifications for Portal Vein Thrombosis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 27ICD9CM, 38NCIt, 55SNOMED-CT, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Portal Vein Thrombosis, Aliases & Descriptions:

Name: Portal Vein Thrombosis 9 11 43 47 60
 
Portal Hypertension Due to Infrahepatic Block 47


Classifications:

Orphanet: 47 
Rare hepatic diseases


Characteristics (Orphanet epidemiological data):

47
portal vein thrombosis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:11695
ICD9CM27 452
NCIt38 C78565
Orphanet47 854
SNOMED-CT55 155455003, 17920008
ICD10 via Orphanet26 I81
UMLS via Orphanet61 C0155773
ICD1025 I81

Related Diseases for Portal Vein Thrombosis

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Diseases related to Portal Vein Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1budd-chiari syndrome31.7F5, SERPINC1
2hepatitis31.5F2, THPO
3portal hypertension31.3THPO, F2
4hepatocellular carcinoma31.3F2, ABCB7, F8
5eclampsia31.0SERPINC1
6hepatitis b30.9ABCB7, F2
7purpura30.9SERPINC1, THPO
8protein c deficiency30.9F5, F2, SERPINC1
9liver cirrhosis30.8ABCB7, F2, SERPINC1, THPO
10lupus erythematosus30.8F2, F5, SERPINC1
11hypersplenism30.7THPO, F2
12homocystinuria30.7F5, SERPINC1
13thrombophilia30.6F5, F8, SERPINC1, F2
14hyperhomocysteinemia30.6SERPINC1, F2, F8, F5
15liver disease30.6THPO, F2, SERPINC1, F5
16protein s deficiency30.5F2, SERPINC1, F8, F5
17pulmonary embolism30.4F2, F5, SERPINC1
18thrombocytosis30.4SERPINC1, THPO, F2
19hepatitis c30.4ABCB7, F2, THPO
20acute myocardial infarction30.3SERPINC1, ABCB7
21antiphospholipid syndrome30.3SERPINC1, F8, F5, F2
22myocardial infarction30.2SERPINC1, F5, ABCB7, F8
23hemophilia a30.1F8, F2, F5, SERPINC1
24disseminated intravascular coagulation29.6F5, SERPINC1, THPO, F2, F8
25pancreatitis10.8
26portal hypertension due to infrahepatic block10.7
27colitis10.6
28ulcerative colitis10.6
29tuberculosis10.6
30cholecystitis10.5
31sneddon syndrome10.5SERPINC1
32central retinal vein occlusion10.5F5
33systemic lupus erythematosus10.5
34obesity10.5
35thalassemia10.5
36acute pancreatitis10.5
37biliary atresia10.5
38abdominal tuberculosis10.5
39hepatic encephalopathy10.5
40schistosomiasis10.5
41chylous ascites10.5
42cytomegalovirus infection10.5
43inflammatory bowel disease10.5
44thrombophlebitis10.5F8
45branch retinal artery occlusion10.4F5
46factor xiii deficiency10.4F5
47homocysteinemia10.4F5
48coronary thrombosis10.4SERPINC1
49renal cell carcinoma10.4
50crohn's disease10.4

Graphical network of the top 20 diseases related to Portal Vein Thrombosis:



Diseases related to portal vein thrombosis

Symptoms for Portal Vein Thrombosis

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Drugs & Therapeutics for Portal Vein Thrombosis

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Drug clinical trials:

Search ClinicalTrials for Portal Vein Thrombosis

Search NIH Clinical Center for Portal Vein Thrombosis

Genetic Tests for Portal Vein Thrombosis

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Anatomical Context for Portal Vein Thrombosis

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MalaCards organs/tissues related to Portal Vein Thrombosis:

31
Liver, Colon, Spleen, Pancreas, Myeloid, Whole blood, Lymph node, Breast, Neutrophil

Animal Models for Portal Vein Thrombosis or affiliated genes

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MGI Mouse Phenotypes related to Portal Vein Thrombosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5F5, SERPINC1, ABCB7, F2
2MP:00053808.4F2, ABCB7, SERPINC1, F5
3MP:00053767.9F5, F8, SERPINC1, ABCB7, F2
4MP:00107687.6F2, ABCB7, SERPINC1, F8, F5

Publications for Portal Vein Thrombosis

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Articles related to Portal Vein Thrombosis:

(show top 50)    (show all 580)
idTitleAuthorsYear
1
Portal vein thrombosis following endoscopic treatment for gastric varices with N-butyl-2-cyanoacrylate: Management with TIPS. (25824931)
2015
2
Efficacy and safety of anticoagulation therapy with different doses of enoxaparin for portal vein thrombosis in cirrhotic patients with hepatitis B. (25856686)
2015
3
Portal vein thrombosis associated with psoriasis: a case report. (25884940)
2015
4
Cirrhosis of liver and portal vein thrombosis - a review article. (25178622)
2014
5
Natural course of nonmalignant partial portal vein thrombosis in cirrhotic patients. (25253363)
2014
6
Chronic idiopathic non-cirrhotic portal vein thrombosis treated with a mesocaval shunt procedure and anticoagulation. (25114412)
2014
7
Portal Vein Thrombosis After Hepatectomy. (24407940)
2014
8
Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib. (23914915)
2013
9
Impact of portal vein thrombosis on the efficacy of endoscopic variceal band ligation. (24084343)
2013
10
Portomesenteric shunt for liver transplantation and complete portal vein thrombosis. (24247901)
2013
11
Portal Vein Thrombosis: A Clinician-Oriented and Practical Review. (23364162)
2013
12
Successful treatment of acute portal vein thrombosis with rivaroxaban. (23846289)
2013
13
Does decreased fibrinolysis have a role to play in the development of non-neoplastic portal vein thrombosis in patients with hepatic cirrhosis? (23504244)
2013
14
Implementation of laparoscopic splenectomy in children and the incidence of portal vein thrombosis diagnosed by ultrasonography. (24210199)
2013
15
Orthotopic liver transplantation in patients with portal vein thrombosis in the absence of hepatocellular carcinoma. (23146508)
2012
16
Optimal length of anticoagulant therapy in cirrhotic patients with portal vein thrombosis. (22387253)
2012
17
Obesity is an independent risk factor for pre-transplant portal vein thrombosis in liver recipients. (22909075)
2012
18
Huge inflammatory pseudotumor of the spleen with postoperative portal vein thrombosis: report of a case. (22160356)
2012
19
Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis. (22819864)
2012
20
Portal vein thrombosis in inflammatory bowel diseases: a single-center case series. (22405175)
2012
21
The inferior mesenteric vein to the left gonadal vein shunt for gastroesophageal varices and extrahepatic portal vein thrombosis after living donor liver transplantation: a case report. (22410077)
2012
22
Evaluation of portal vein thrombosis in liver graft ten years after liver transplantation due to budd-Chiari syndrome using Doppler ultrasound. (23322979)
2012
23
An early single-center experience of portal vein thrombosis in living donor liver transplantation: clinical feature, management and outcome. (22066098)
2011
24
Portal vein thrombosis and budd-Chiari syndrome. (22054734)
2011
25
Caval inflow to the graft for liver transplantation in patients with diffuse portal vein thrombosis: a 12-year experience. (21869678)
2011
26
Case of asymptomatic portal vein thrombosis after cesarean delivery. (21599802)
2011
27
A rare cause of portal vein thrombosis in a previously healthy young man with acute hepatitis. (21493127)
2011
28
Portal vein thrombosis in biliary atresia patients after living donor liver transplantation. (20570300)
2011
29
Extrahepatic portal vein thrombosis after umbilical catheterization: is it a good choice for Rex shunt? (21238670)
2011
30
Chemoembolization for unresectable hepatocellular carcinoma in patients with or without portal vein thrombosis. (21443089)
2010
31
Transjugular intrahepatic portosystemic shunt with thrombectomy for the treatment of portal vein thrombosis after liver transplantation. (19242796)
2010
32
Posttransplant bilioportal fistula with portal vein thrombosis: a case report. (21094871)
2010
33
VKORC1 and CYP2C9 genetic polymorphisms in hepatic or portal vein thrombosis. (20434758)
2010
34
Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study. (19821530)
2010
35
Portal vein thrombosis and liver transplantation: long term. (20304176)
2010
36
Liver transplantation in end-stage liver disease with portal vein thrombosis]. (19595038)
2009
37
Pancreatic laceration and portal vein thrombosis in blunt trauma abdomen. (20011472)
2008
38
Portal vein thrombosis: CT features. (17694406)
2008
39
Management of portal vein thrombosis. (21960890)
2008
40
Late onset portal vein thrombosis and its risk factors. (18705318)
2008
41
Superior mesenteric and portal vein thrombosis caused by congenital antithrombin III deficiency: report of a case. (17387563)
2007
42
High FVIII level is associated with idiopathic portal vein thrombosis in South India. (17524760)
2007
43
Experimental hepatic radiofrequency ablation using wet electrodes: electrode-to-vessel distance is a significant predictor for delayed portal vein thrombosis. (16541225)
2006
44
Acute idiopathic portal vein thrombosis in a child: a case report and literature review. (16378832)
2006
45
Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy. (16557541)
2006
46
Factor V Leiden is not commonly associated with idiopathic portal vein thrombosis in southern India. (16877827)
2006
47
Extrahepatic portal vein thrombosis in children: etiology and long-term follow-up. (15087698)
2004
48
Portal vein thrombosis after variceal endoscopic sclerotherapy in cirrhotic patients: role of genetic thrombophilia. (12170404)
2002
49
Portal vein thrombosis associated with hilar bile duct carcinoma and liver abscess. (11269004)
2001
50
Portal vein thrombosis caused by protein C and protein S deficiency associated with cytomegalovirus infection. (7699538)
1995

Variations for Portal Vein Thrombosis

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Expression for genes affiliated with Portal Vein Thrombosis

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Search GEO for disease gene expression data for Portal Vein Thrombosis.

Pathways for genes affiliated with Portal Vein Thrombosis

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Compounds for genes affiliated with Portal Vein Thrombosis

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Compounds related to Portal Vein Thrombosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idCompoundScoreTop Affiliating Genes
1certoparin439.7F2, SERPINC1
2deae-sephadex a-50439.6F2, F8
3polybrene439.5SERPINC1, F2
4inogatran439.5F2, SERPINC1, F5
5hirugen439.5F2, SERPINC1, F5
6ecarin439.5F5, SERPINC1, F2
7spectrozyme439.5SERPINC1, F2, F5
8danaparoid439.5F5, SERPINC1, F2
9ximelagatran43 1210.5F5, F2, SERPINC1
10ancrod439.5F2, F5, SERPINC1
11heparinoids439.5SERPINC1, F5, F2
12fondaparinux439.5F5, F2, SERPINC1
13bivalirudin43 1210.5F5, SERPINC1, F2
14desogestrel43 1210.5F5, SERPINC1, F2
15argatroban43 1210.5SERPINC1, F5, F2
16protamine sulfate439.5F2, SERPINC1, F5
17gestodene43 1210.4F2, SERPINC1, F5
18levonorgestrel43 59 28 1212.4SERPINC1, F5, F2
19hydroxyethyl starch439.4F8, SERPINC1, F2
20coumarin43 2 49 2412.4SERPINC1, F5, F2
21kaolin439.4F2, F5, F8
22tranexamic acid43 1210.4F8, F2, SERPINC1
23protamine439.3F5, SERPINC1, F2
24dermatan sulfate439.3F2, SERPINC1, F5
25kininogen439.3SERPINC1, F2, F5
26cardiolipin43 1210.3F2, F5, F8
27phosphatidylethanolamine43 1210.3F5, F8, F2
28rfviii439.2F8, F5
29aprotinin43 1210.2SERPINC1, F2, F5
30acetaminophen43 2 49 24 1213.1F8, F2, F5
31progestin439.1F5, F8, SERPINC1
32ristocetin439.0F5, F8, SERPINC1, F2
33desmopressin43 59 28 1212.0SERPINC1, F8, F5, F2
34warfarin43 49 24 1212.0SERPINC1, F5, F8, F2
35homocysteine43 249.9F5, F8, SERPINC1, F2
36citrate438.9F2, SERPINC1, F8, F5
37prostacyclin438.6F5, SERPINC1, F8, THPO
38tamoxifen43 49 28 1211.5THPO, F5, SERPINC1, F2
39polysaccharide438.5THPO, F8, SERPINC1, F5
40epinephrine43 24 1210.5F2, F5, THPO, F8
41aspartate438.3F5, F8, ABCB7, F2
42hirudin438.2F5, F2, THPO, SERPINC1, F8
43polyethylene glycol438.2THPO, SERPINC1, F5, F2, F8
44aspirin43 49 28 2411.2F2, SERPINC1, F8, THPO, F5
45estrogen438.0SERPINC1, F8, F2, THPO, F5
46lactate437.9ABCB7, F2, THPO, F5, F8
47fibrinogen437.6F8, SERPINC1, ABCB7, F2, THPO, F5
48creatinine437.6F2, F5, F8, SERPINC1, THPO, ABCB7
49heparin43 28 24 1210.6F5, THPO, F8, SERPINC1, ABCB7, F2
50alanine437.5F2, ABCB7, THPO, F8, F5, SERPINC1

GO Terms for genes affiliated with Portal Vein Thrombosis

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Cellular components related to Portal Vein Thrombosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.5SERPINC1, F2
2platelet alpha granule lumenGO:00310939.4F8, F5
3extracellular regionGO:00055768.3F5, F8, SERPINC1, F2
4extracellular spaceGO:00056157.7F5, F8, SERPINC1, THPO, F2

Biological processes related to Portal Vein Thrombosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:00075979.4F8, F2
2acute-phase responseGO:00069539.3F2, F8
3platelet degranulationGO:00025769.2F5, F8
4positive regulation of protein phosphorylationGO:00019349.1THPO, F2
5platelet activationGO:00301688.2F2, THPO, F8, F5
6blood coagulationGO:00075967.9F5, F8, SERPINC1, THPO, F2

Molecular functions related to Portal Vein Thrombosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.5F5, F8
2serine-type endopeptidase activityGO:00042528.7F5, F8, F2

Products for genes affiliated with Portal Vein Thrombosis

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Sources for Portal Vein Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet