MCID: PRT018
MIFTS: 54

Portal Vein Thrombosis malady

Cardiovascular, Liver, Blood categories

Summaries for Portal Vein Thrombosis

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Portal vein thrombosis is a form of venous thrombosis affecting the hepatic portal vein, which can lead... more...

MalaCards: Portal Vein Thrombosis, also known as portal hypertension due to infrahepatic block, is related to hepatic vein thrombosis and portal hypertension. An important gene associated with Portal Vein Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are TGF-Beta Pathway and PTM: gamma carboxylation, hypusine formation and arylsulfatase activation. The compounds acetaminophen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include liver, lymph node and spleen, and related mouse phenotypes are immune system and hematopoietic system.

Description from OMIM:47 601004

Aliases & Classifications for Portal Vein Thrombosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular, Liver, Blood


Characteristics (Orphanet epidemiological data):

49
portal vein thrombosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

portal vein thrombosis 8 10 45 49 47 61
portal hypertension due to infrahepatic block 49


External Ids:

Disease Ontology8 DOID:11695
ICD9CM27 452
NCIt40 C78565
OMIM47 601004
SNOMED-CT57 155455003, 17920008
ICD10 via Orphanet26 I81
SNOMED-CT via Orphanet58 17920008
UMLS via Orphanet62 C0155773
ICD1025 I81

Related Diseases for Portal Vein Thrombosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Portal Vein Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1hepatic vein thrombosis31.3PROS1
2portal hypertension31.2THPO, F2, SST
3hepatitis c30.9IFNAR2, IFNA2, AFP, ABCB7, F2, THPO
4venous thrombosis30.8PROS1, F2, SELP, SERPINC1, APOH, F8
5hepatitis a30.8F2, F8
6acute pancreatitis30.8SST, ABCB7
7myeloproliferative disorder30.8SELP, THPO, JAK2, IFNA2
8protein c deficiency30.8APOH, F5, MTHFR, PROS1, F2, SERPINC1
9hyperhomocysteinemia30.8APOH, F8, F5, MTHFR, PROS1, F2
10thrombophilia30.7F5, MTHFR, PROS1, F2, SELP, SERPINC1
11antiphospholipid syndrome30.7SERPINC1, SELP, F2, PROS1, APOH, F8
12protein s deficiency30.6APOH, F8, F5, MTHFR, PROS1, F2
13hypersplenism30.5F2, THPO
14thrombocytosis30.5SERPINC1, IFNA2, JAK2, F2, THPO, SELP
15thromboembolism30.5APOH, F8, F5, MTHFR, CYP2C9, F2
16sickle cell disease30.3SELP
17eclampsia30.3SERPINC1, MTHFR
18acute myocardial infarction30.3ABCB7, SELP, SERPINC1
19homocystinuria30.3SERPINC1, MTHFR, F5
20prothrombin deficiency30.3APOH, F5, F2, SERPINC1
21polycythemia vera30.3IFNA2, JAK2, THPO, SELP
22viral hepatitis30.3IFNA2, F8, AFP, ABCB7, F2
23systemic mastocytosis30.3IFNA2, JAK2
24sepsis30.3F5, F2, TTF2, SELP, SERPINC1
25chronic myeloid leukemia30.3IFNA2, JAK2, THPO, SELP
26adenoma30.2REN, CYP2C9, SST, MTHFR
27adenocarcinoma30.2IFNAR2, JAK2, PROS1, AFP, SST, TTF2
28vein disease10.9
29portal hypertension due to infrahepatic block10.6
30ulcerative colitis10.6
31n syndrome10.6
32tuberculosis10.5
33cytomegalovirus infection10.5
34biliary atresia10.4
35abdominal tuberculosis10.4
36thalassemia10.4
37chylous ascites10.4
38protein r deficiency10.4
39hepatic tuberculosis10.3
40hepatitis e10.3
41beta thalassemia10.3
42systemic lupus erythematosus10.3
43coronary thrombosis10.3
44morbid obesity10.3
45adult-onset still's disease10.3
46cholelithiasis10.3
47bile duct carcinoma10.3
48turner syndrome10.3
49hypereosinophilic syndrome10.3
50hepatitis c virus10.3

Graphical network of the top 20 diseases related to Portal Vein Thrombosis:



Diseases related to portal vein thrombosis

Clinical Features for Portal Vein Thrombosis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

601004

Clinical synopsis from OMIM:

601004

Drugs & Therapeutics for Portal Vein Thrombosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Portal Vein Thrombosis

Drug clinical trials:

Search ClinicalTrials for Portal Vein Thrombosis

Search NIH Clinical Center for Portal Vein Thrombosis

Search CenterWatch for Portal Vein Thrombosis

Genetic Tests for Portal Vein Thrombosis

Anatomical Context for Portal Vein Thrombosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Portal Vein Thrombosis:

33
Liver, Lymph node, Spleen, Whole blood, Colon, Pancreas, Breast, Myeloid, T cells, B cells, Endothelial, Fetal liver, Pancreatic islet

Animal Models for Portal Vein Thrombosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Portal Vein Thrombosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.9F8, JAK2, SST, REN, F2, THPO
2MP:00053978.6IFNAR2, F8, JAK2, PROS1, REN, F2
3MP:00107688.1IFNAR2, APOH, F8, JAK2, F5, MTHFR
4MP:00053767.8SERPINC1, IFNAR2, APOH, F8, JAK2, F5

Publications for Portal Vein Thrombosis

Sources:
51PubMed
See all sources

Articles related to Portal Vein Thrombosis:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Transarterial chemoembolisation (TACE) combined with endovascular implantation of an iodine-125 seed strand for the treatment of hepatocellular carcinoma with portal vein tumour thrombosis versus TACE alone: a two-arm, randomised clinical trial. (24374800)
2014
2
Imaging in clinical decision-making for portal vein thrombosis. (24419395)
2014
3
Radioembolization for hepatocellular carcinoma with portal vein thrombosis: impact of liver function on systemic treatment options at disease progression. (23000237)
2013
4
Survival of patients with portal vein thrombosis: analysis based on disease onset. (22693106)
2013
5
Portal vein thrombosis in patients with end stage liver disease awaiting liver transplantation: outcome of anticoagulation. (23314858)
2013
6
Cavernous transformation of portal vein secondary to portal vein thrombosis: a case report. (22383935)
2012
7
Should anticoagulants be administered for portal vein thrombosis associated with acute pancreatitis? (23155349)
2012
8
Degree of portal vein thrombosis might be associated with recanalization during anticoagulation. (22373725)
2012
9
Prevalence of the JAK2V617F mutation in Chinese patients with Budd-Chiari syndrome and portal vein thrombosis: a prospective study. (22142461)
2012
10
Transjugular intrahepatic portosystemic shunt may be superior to conservative therapy for variceal rebleeding in cirrhotic patients with non-tumoral portal vein thrombosis: a hypothesis. (22847208)
2012
11
Evaluation of the presence of hereditary and acquired thrombophilias in Brazilian children and adolescents with diagnoses of portal vein thrombosis. (22684349)
2012
12
Efficacy of transjugular intrahepatic portosystemic shunt to prevent total portal vein thrombosis in cirrhotic patients awaiting for liver transplantation. (23146469)
2012
13
Case of asymptomatic portal vein thrombosis after cesarean delivery. (21599802)
2011
14
Portal vein thrombosis in biliary atresia patients after living donor liver transplantation. (20570300)
2011
15
Correlation of splenectomy with portal vein thrombosis in beta-thalassemia major. (22355997)
2011
16
Tips for portal vein thrombosis (pvt) in cirrhosis: not only unblocking a pipe. (21419182)
2011
17
Outcome of modified portal vein anastomosis for recipients with portal vein thrombosis or stenosis before living donor liver transplantation. (22152867)
2011
18
Atypical enhancement pattern of hepatocellular carcinoma with portal vein thrombosis on multiphasic CT. (22206054)
2011
19
Neonatal portal vein thrombosis: diagnosis and management. (21925985)
2011
20
No-touch hepatic hilum technique to treat early portal vein thrombosis after pediatric liver transplantation. (20887425)
2010
21
Long-term survival after portal vein arterialization for portal vein thrombosis in orthotopic liver transplantation. (19643558)
2010
22
Criteria for diagnosing benign portal vein thrombosis in the assessment of patients with cirrhosis and hepatocellular carcinoma for liver transplantation. (20440775)
2010
23
Extrahepatic portal vein thrombosis in children and adolescents: Influence of genetic thrombophilic disorders. (21182228)
2010
24
The preferable treatment for cirrhotic portal vein thrombosis: anticoagulation or transjugular intrahepatic portosystemic shunt? (20104582)
2010
25
Liver transplant recipients with portal vein thrombosis: a single center retrospective study. (19208512)
2009
26
Pulmonary embolism and portal vein thrombosis in an immunocompetent adolescent with acute cytomegalovirus hepatitis. (19116696)
2009
27
MTHFR C677TT, PAI1 4G-4G, V Leiden Q506, and prothrombin G20210A in hepatocellular carcinoma with and without portal vein thrombosis. (18618228)
2009
28
Chronic portal vein thrombosis after liver transplantation in a child treated by a combined minimally invasive approach. (19387727)
2009
29
Pancreatic laceration and portal vein thrombosis in blunt trauma abdomen. (20011472)
2008
30
Liver transplantation in the setting of hepatocellular carcinoma and portal vein thrombosis: a challenging dilemma? (18080191)
2008
31
Extrahepatic portal vein thrombosis. (18814081)
2008
32
Altered liver morphology after portal vein thrombosis: not always cirrhosis. (18270830)
2008
33
Superior mesenteric and portal vein thrombosis caused by congenital antithrombin III deficiency: report of a case. (17387563)
2007
34
Tuberous sclerosis with portal vein thrombosis, protein C and S deficiency. (18032862)
2007
35
Idiopathic portal vein thrombosis and FVIII levels. (17011614)
2007
36
Portal vein thrombosis 1 month after a sigmoidectomy for colon cancer revealing an antiphospholipid antibody syndrome. (17489064)
2007
37
Experimental hepatic radiofrequency ablation using wet electrodes: electrode-to-vessel distance is a significant predictor for delayed portal vein thrombosis. (16541225)
2006
38
Portal vein thrombosis is a common complication following splenectomy in patients with malignant haematological diseases. (16923107)
2006
39
Budd-Chiari syndrome and acute portal vein thrombosis: management by a transjugular intrahepatic portosystemic shunt (TIPS) and portal vein interventions via a TIPS. (16504889)
2006
40
Diagnosis of benign and malignant portal vein thrombosis in cirrhotic patients with hepatocellular carcinoma: color Doppler US, contrast-enhanced US, and fine-needle biopsy. (16865315)
2006
41
Portal vein thrombosis: evolving techniques to attack this old nemesis. (16799936)
2006
42
Correction of extrahepatic portal vein thrombosis by the mesenteric to left portal vein bypass. (16552203)
2006
43
Portal vein thrombosis: what is the role of genetics? (15947546)
2005
44
Acute portal vein thrombosis after splenic embolization and splenectomy for autoimmune pancytopenia. (16254850)
2005
45
Eversion thromboendovenectomy in organized portal vein thrombosis during liver transplantation. (15108774)
2004
46
Rapid resolution of portal vein thrombosis and noncirrhotic portal hypertension following cyto-reductive therapy in a patient with chronic myeloid leukemia. (14614643)
2003
47
Portal vein thrombosis after variceal endoscopic sclerotherapy in cirrhotic patients: role of genetic thrombophilia. (12170404)
2002
48
Portal vein thrombosis after hematopoietic cell transplantation: frequency, treatment and outcome. (11896430)
2002
49
Portal vein thrombosis associated to prothrombin G20210A mutation and protein C deficiency. (10898280)
2000
50
Deficiency of natural anticoagulant proteins C, S, and antithrombin in portal vein thrombosis: a secondary phenomenon? (10716684)
2000

Genetic Variations for Portal Vein Thrombosis

Expression for genes affiliated with Portal Vein Thrombosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Portal Vein Thrombosis

Search GEO for disease gene expression data for Portal Vein Thrombosis.

Pathways for genes affiliated with Portal Vein Thrombosis

Sources:
52QIAGEN, 54Reactome, 50PharmGKB, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Pathways related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2THPO, F2
29.9F2, PROS1, VKORC1
3
Hide members
9.9F2, PROS1, VKORC1
49.9JAK2, IFNA2, IFNAR2
59.9PROS1, F2, SELP
6
Hide members
9.8F2, THPO, SELP, SERPINC1
7
Hide members
9.8F5, PROS1, F2, SERPINC1
8
Hide members
9.7F8, F5, PROS1, SELP
9
Hide members
9.7F8, F5, PROS1, F2, SERPINC1
10
Hide members
9.7F8, F5, PROS1, F2, SERPINC1
11
Hide members
9.7SERPINC1, F2, PROS1, F5, F8
12
Hide members
9.5IFNA2, F8, JAK2, F5, PROS1

Compounds for genes affiliated with Portal Vein Thrombosis

Sources:
45Novoseek, 2BitterDB, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1acetaminophen45 2 50 11 2414.4CYP2C9
2estrogen4510.4THPO, F8, APOH
3coumarins4510.3CYP2C9, VKORC1, APOH
4ximelagatran45 1111.2F5, CYP2C9, F2, SERPINC1
5kaolin4510.2F2, F8, F5, APOH
6inogatran4510.2F5, F2, SERPINC1
7bivalirudin45 1111.2SERPINC1, SELP, F2, F5
8acenocoumarol45 50 1112.2F2, F5, CYP2C9, VKORC1
9argatroban45 1111.2SELP, SERPINC1, F2, F5
10hydroxyethyl starch4510.1F2, F8, SERPINC1, SELP
11phenprocoumon45 50 1112.1SERPINC1, VKORC1, F2, CYP2C9
12Drotrecogin alfa1110.1F5, F8, PROS1, F2
13ristocetin4510.1F5, F8, SELP, SERPINC1, F2
14aspartate4510.1F8, JAK2, AFP, ABCB7, F2
15ecarin4510.1F5, SERPINC1, F2
16coumarin45 2 50 2413.1VKORC1, F5, CYP2C9, SERPINC1, F2
17uric acid45 2411.1ABCB7, AFP, F5, APOH, TTF2
18dextran sulfate4510.0F5, JAK2, APOH, SELP
19gamma-carboxyglutamic acid4510.0F5, VKORC1, PROS1, F2
20hirudin4510.0THPO, SERPINC1, SELP, F2, F5, F8
21ticlopidine45 1111.0SELP, APOH, SERPINC1, CYP2C9
22desmopressin45 60 29 1112.9F5, F2, SELP, SERPINC1, F8, REN
23dexamethasone45 50 29 1112.9REN, CYP2C9, PROS1, F8, AFP
24warfarin45 50 11 2412.8SELP, SERPINC1, TTF2, APOH, VKORC1, CYP2C9
25kininogen459.8SERPINC1, F2, REN, F5, APOH, SELP
26polyethylene glycol459.8F8, F5, IFNA2, AFP, F2, THPO
27sialic acid459.7AFP, APOH, ABCB7, F8, SELP, THPO
28homocysteine45 2410.7APOH, SELP, F5, F8, SERPINC1, F2
29carboplatin45 50 1111.6MTHFR, IFNA2, AFP, SST, THPO
30glucose459.6TTF2, CYP2C9, PROS1, APOH, IFNA2, REN
31vitamin-e459.5PROS1, ABCB7, F5, JAK2, IFNA2
32diltiazem45 29 1111.5REN, CYP2C9, SERPINC1, F2
335fluorouracil459.4THPO, CYP2C9, SST, MTHFR, IFNA2, IFNAR2
34cyclophosphamide45 50 1111.4F8, MTHFR, F5, IFNA2, APOH, AFP
35lactate459.4ABCB7, F2, F5, AFP, F8, APOH
36progesterone45 60 29 11 2413.3F8, IFNA2, F5, AFP, CYP2C9, ABCB7
37heparin45 29 11 2412.3THPO, TTF2, ABCB7, AFP, PROS1, MTHFR
38prostacyclin459.2SELP, THPO, APOH, F8, F5, PROS1
39fibrinogen459.2APOH, F8, F5, AFP, ABCB7, F2
40cyclosporin a45 29 6011.1JAK2, TTF2, SELP, F8, MTHFR, CYP2C9
41nitric oxide45 11 2411.1THPO, CYP2C9, F5, JAK2, APOH, F8
42testosterone45 60 11 2412.1AFP, ABCB7, PROS1, MTHFR, SST, F5
43aspirin45 50 29 2412.1JAK2, F5, MTHFR, CYP2C9, F2, TTF2
44alanine458.9SERPINC1, ABCB7, THPO, TTF2, IFNAR2, F2
45retinoic acid45 249.9MTHFR, AFP, IFNA2, SST, CYP2C9, THPO
46epinephrine45 11 2410.9F8, SELP, JAK2, F5, AFP, SST
47steroid458.8JAK2, CYP2C9, AFP, PROS1, F5, F8
48cholesterol45 29 11 2411.7JAK2, APOH, F8, F5, SELP, TTF2
49creatinine458.7SERPINC1, SELP, THPO, TTF2, F2, ABCB7
50vegf458.5SERPINC1, SELP, F5, TTF2, REN, SST

GO Terms for genes affiliated with Portal Vein Thrombosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.9PROS1, F5, F8
2extracellular regionGO:0055768.5IFNAR2, IFNA2, F8, F5, PROS1, SST
3extracellular spaceGO:0056158.2SERPINC1, IFNAR2, IFNA2, APOH, F8, F5

Biological processes related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:03019410.2F2, APOH
2blood coagulation, intrinsic pathwayGO:00759710.1F2, F8, APOH
3peptidyl-glutamic acid carboxylationGO:01718710.1F2, PROS1, VKORC1
4positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.9JAK2, F2, SELP
5platelet degranulationGO:0025769.9F8, F5, PROS1, SELP
6negative regulation of fibrinolysisGO:0519189.9F2, APOH
7cell surface receptor signaling pathwayGO:0071669.7IFNAR2, IFNA2, SST, F2
8platelet activationGO:0301689.6F8, F5, PROS1, F2, THPO, SELP
9cellular protein metabolic processGO:0442679.4RPL36, VKORC1, PROS1, REN, F2
10blood coagulationGO:0075969.1SERPINC1, IFNA2, F8, JAK2, F5, PROS1

Products for genes affiliated with Portal Vein Thrombosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Portal Vein Thrombosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet