MCID: PRT018
MIFTS: 57

Portal Vein Thrombosis malady

Cardiovascular diseases, Liver diseases, Blood diseases categories

Summaries for Portal Vein Thrombosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Portal vein thrombosis is a form of venous thrombosis affecting the hepatic portal vein, which can lead... more...

MalaCards: Portal Vein Thrombosis, also known as portal hypertension due to infrahepatic block, is related to hepatocellular carcinoma and hepatic vein thrombosis. An important gene associated with Portal Vein Thrombosis is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are TGF-Beta Pathway and PTM: gamma carboxylation, hypusine formation and arylsulfatase activation. The compounds acetaminophen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and spleen, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Portal Vein Thrombosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Liver diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

48
portal vein thrombosis:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable


Aliases & Descriptions:

portal vein thrombosis 8 10 44 48 60
portal hypertension due to infrahepatic block 48


External Ids:

Disease Ontology8 DOID:11695
ICD9CM27 452
NCIt39 C78565
ICD10 via Orphanet26 I81
SNOMED-CT56 155455003, 17920008
SNOMED-CT via Orphanet57 17920008
UMLS via Orphanet61 C0155773
ICD1025 I81

Related Diseases for Portal Vein Thrombosis

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17GeneCards, 18GeneDecks
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Diseases related to Portal Vein Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1hepatocellular carcinoma31.5IFNAR2, IFNA2, F8, AFP, ABCB7, F2
2hepatic vein thrombosis31.4PROS1
3hepatitis31.4SELP, THPO, F2, AFP, IFNA2
4liver cirrhosis31.3AFP, IFNA2, SST, REN, ABCB7, F2
5portal hypertension31.1THPO, F2, SST
6hypertension31.1F5, MTHFR, PROS1, REN, F2
7pancreatitis31.1SELP, SST
8hepatitis a30.9F2, F8
9protein c deficiency30.9APOH, F5, MTHFR, PROS1, F2, SERPINC1
10protein s deficiency30.8APOH, F8, F5, MTHFR, PROS1, F2
11acute pancreatitis30.8SST, ABCB7
12hyperhomocysteinemia30.7APOH, F8, F5, MTHFR, PROS1, F2
13purpura30.7THPO, SERPINC1
14thrombophilia30.7F5, MTHFR, PROS1, F2, SELP, SERPINC1
15antiphospholipid syndrome30.7SERPINC1, SELP, F2, PROS1, APOH, F8
16obesity30.6TTF2, ABCB7, JAK2
17hepatitis b30.6F2, ABCB7, AFP, IFNA2
18hepatitis c30.6IFNAR2, IFNA2, AFP, ABCB7, F2, THPO
19factor v deficiency30.4F8, F5, F2
20lupus erythematosus30.4APOH, IFNA2
21prothrombin deficiency30.4APOH, F5, F2, SERPINC1
22hypersplenism30.4F2, THPO
23antithrombin iii deficiency30.4APOH, F5, MTHFR, PROS1, F2, SERPINC1
24thrombocytosis30.4SERPINC1, IFNA2, JAK2, F2, THPO, SELP
25myocardial infarction30.4F5, MTHFR, CYP2C9, REN, ABCB7, SELP
26nephrotic syndrome30.2SERPINC1
27pre-eclampsia30.2AFP
28sickle cell disease30.2SELP
29polycythemia30.2THPO, JAK2
30eclampsia30.2SERPINC1, MTHFR
31peritonitis30.2F2, SELP
32ischemia30.2SELP, JAK2
33acute myocardial infarction30.2ABCB7, SELP, SERPINC1
34essential hypertension30.2SELP, REN
35sarcoma30.2F8, JAK2, THPO
36homocystinuria30.2SERPINC1, MTHFR, F5
37myeloid leukemia30.2JAK2, TTF2, THPO
38cerebrovascular disease30.2APOH, MTHFR, SELP
39colon cancer30.2TTF2, MTHFR, JAK2
40disseminated intravascular coagulation30.2F8, F5, F2, THPO, SERPINC1
41polycythemia vera30.2IFNA2, JAK2, THPO, SELP
42viral hepatitis30.2IFNA2, F8, AFP, ABCB7, F2
43systemic mastocytosis30.2IFNA2, JAK2
44leukemia30.2IFNA2, F8, JAK2, MTHFR, THPO
45chronic myeloid leukemia30.2IFNA2, JAK2, THPO, SELP
46pulmonary embolism30.2APOH, F5, MTHFR, PROS1, F2, SERPINC1
47adenocarcinoma30.2IFNAR2, JAK2, PROS1, AFP, SST, TTF2
48vein disease10.9
49liver disease10.6
50portal hypertension due to infrahepatic block10.6

Graphical network of the top 20 diseases related to Portal Vein Thrombosis:



Diseases related to portal vein thrombosis

Clinical Features for Portal Vein Thrombosis

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Drugs & Therapeutics for Portal Vein Thrombosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Portal Vein Thrombosis

Drug clinical trials:

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Search CenterWatch for Portal Vein Thrombosis

Genetic Tests for Portal Vein Thrombosis

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Anatomical Context for Portal Vein Thrombosis

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32MalaCards
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MalaCards organs/tissues related to Portal Vein Thrombosis:

32
Liver, Colon, Spleen, Pancreas, Whole blood, Lymph node, Breast, Myeloid, Endothelial

Animal Models for Portal Vein Thrombosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Portal Vein Thrombosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.9F8, JAK2, SST, REN, F2, THPO
2MP:00053978.6IFNAR2, F8, JAK2, PROS1, REN, F2
3MP:00107688.1IFNAR2, APOH, F8, JAK2, F5, MTHFR
4MP:00053767.8SERPINC1, IFNAR2, APOH, F8, JAK2, F5

Publications for Portal Vein Thrombosis

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Sources:
50PubMed
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Articles related to Portal Vein Thrombosis:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Impact of portal vein thrombosis on the efficacy of endoscopic variceal band ligation. (24084343)
2013
2
Portomesenteric shunt for liver transplantation and complete portal vein thrombosis. (24247901)
2013
3
Portal vein thrombosis after colectomy for ulcerative colitis: two case reports and proposed novel pathophysiology for this association. (23648231)
2013
4
Value of D-dimer and protein S for diagnosis of portal vein thrombosis in patients with liver cirrhosis. (23637275)
2013
5
Risk factors and clinical characteristics of portal vein thrombosis after splenectomy in patients with liver cirrhosis. (24103282)
2013
6
Rapidly progressive hepatocellular carcinoma mimicking benign portal vein thrombosis: a case report. (23423240)
2013
7
Transjugular intrahepatic portosystemic shunt for symptomatic portal hypertension in hepatocellular carcinoma with portal vein tumor thrombosis. (23679937)
2013
8
Case reports of portal vein thrombosis and bile duct stenosis after stereotactic body radiation therapy for hepatocellular carcinoma. (24102845)
2013
9
Obesity is an independent risk factor for pre-transplant portal vein thrombosis in liver recipients. (22909075)
2012
10
Huge inflammatory pseudotumor of the spleen with postoperative portal vein thrombosis: report of a case. (22160356)
2012
11
Antiannexin V antibodies: an underestimated source of noncirrhotic portal vein thrombosis? (22371219)
2012
12
Portal vein thrombosis following laparoscopic sleeve gastrectomy for morbid obesity. (23484577)
2012
13
The role of portal vein thrombosis in the clinical course of inflammatory bowel diseases: report on three cases and review of the literature. (23093957)
2012
14
Hepatocellular carcinoma presenting as an incidental isolated malignant portal vein thrombosis. (21190093)
2012
15
What we should know about portal vein thrombosis in cirrhotic patients: a changing perspective. (23049208)
2012
16
A case report of minimal change nephrotic syndrome complicated with portal, splenic and superior mesenteric vein thrombosis. (22595395)
2012
17
Hypercoagulability in end-stage liver disease: prevalence and its correlation with severity of liver disease and portal vein thrombosis. (22496089)
2012
18
Clostridium clostridioforme liver abscess complicated by portal vein thrombosis in childhood. (21940652)
2012
19
Low-molecular-weight heparin successfully used to treat a nephrotic patient complicated by superior mesenteric vein thrombosis and portal vein thrombosis. (21252580)
2011
20
Validation of an extension of the international non-invasive criteria for the diagnosis of hepatocellular carcinoma to the characterization of macroscopic portal vein thrombosis. (21054520)
2011
21
Impressive efficacy of sorafenib in a patient with an hepatocellular carcinoma and a portal vein thrombosis associated with a metastatic ENT cancer. (20936376)
2011
22
A case of portal vein thrombosis caused by ingestion of a foreign body. (21288517)
2011
23
A case of idiopathic portal vein thrombosis? (20007958)
2010
24
Portal vein thrombosis. (20103016)
2010
25
Radioembolization with use of yttrium-90 resin microspheres in patients with hepatocellular carcinoma and portal vein thrombosis. (20598574)
2010
26
Use of yttrium-90 microspheres in patients with advanced hepatocellular carcinoma and portal vein thrombosis. (20691606)
2010
27
Inherited dysfibrinogenaemia presenting with portal vein thrombosis. (21043359)
2010
28
Budd-Chiari syndrome and portal vein thrombosis due to essential thrombocytosis. (20085436)
2010
29
Anticoagulation for portal vein thrombosis in cirrhosis. (20800136)
2010
30
Single-center experience of 253 portal vein thrombosis patients undergoing liver transplantation in China. (19917382)
2009
31
Late onset portal vein thrombosis and its risk factors. (18705318)
2008
32
Endovascular management of early portal vein thrombosis caused by coronary vein steal after liver transplantation and its outcome. (18460001)
2008
33
Protective effect of resveratrol, a red wine constituent polyphenol, on rats subjected to portal vein thrombosis. (18261608)
2008
34
Portal vein thrombosis in liver cirrhosis. (18274708)
2008
35
Left renal vein as an option for portal inflow in liver transplant recipients with portal vein thrombosis. (18363575)
2008
36
High FVIII level is associated with idiopathic portal vein thrombosis in South India. (17524760)
2007
37
Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with and without underlying cirrhosis. (17242876)
2007
38
Coagulation abnormalities in cirrhotic patients with portal vein thrombosis. (18257465)
2007
39
Portal vein thrombosis in children and adolescents. (16773174)
2006
40
Portal vein thrombosis uncommon clinical picture. (16771135)
2006
41
Portal vein thrombosis in the neonate: risk factors, course, and outcome. (16769378)
2006
42
Duodenal dearterialization and stapling for severe hemorrhage from duodenal varices with portal vein thrombosis. (15701491)
2005
43
Thrombophilic conditions in non-cirrhotic portal vein thrombosis. (16361765)
2005
44
Massive intraabdominal bleeding as a complication of acute cholangitis and portal vein thrombosis due to cholecystocholedocolithiasis. (15906761)
2005
45
Portal vein thrombosis: etiology, diagnostic strategy, therapy and management. (15968889)
2005
46
Portal vein thrombosis, a cause of obstructive jaundice. (14988849)
2004
47
Portal vein thrombosis associated with factor V Leiden mutation in a woman who underwent exchange transfusion at birth]. (12910230)
2003
48
Portal vein thrombosis following splenectomy: identification of risk factors. (14627254)
2003
49
Combination chemotherapy for advanced hepatocellular carcinoma complicated by major portal vein thrombosis. (11868789)
2002
50
Bacteroides fragilis bacteremia associated with portal vein and superior mesentery vein thrombosis secondary to antithrombin III and protein C deficiency: a case report. (12542252)
2002

Genetic Variations for Portal Vein Thrombosis

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Expression for genes affiliated with Portal Vein Thrombosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Portal Vein Thrombosis

Search GEO for disease gene expression data for Portal Vein Thrombosis.

Pathways for genes affiliated with Portal Vein Thrombosis

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51QIAGEN, 53Reactome, 49PharmGKB, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2THPO, F2
29.9F2, PROS1, VKORC1
3
Hide members
9.9F2, PROS1, VKORC1
49.9JAK2, IFNA2, IFNAR2
59.9PROS1, F2, SELP
6
Hide members
9.8F2, THPO, SELP, SERPINC1
7
Hide members
9.8F5, PROS1, F2, SERPINC1
8
Hide members
9.7F8, F5, PROS1, SELP
9
Hide members
9.7F8, F5, PROS1, F2, SERPINC1
10
Hide members
9.7F8, F5, PROS1, F2, SERPINC1
11
Hide members
9.7SERPINC1, F2, PROS1, F5, F8
12
Hide members
9.5IFNA2, F8, JAK2, F5, PROS1

Compounds for genes affiliated with Portal Vein Thrombosis

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Sources:
44Novoseek, 2BitterDB, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show top 50)    (show all 189)
idCompoundScoreTop Affiliating Genes
1acetaminophen44 2 49 11 2414.4CYP2C9
2estrogen4410.4THPO, F8, APOH
3coumarins4410.3CYP2C9, VKORC1, APOH
4ximelagatran44 1111.2F5, CYP2C9, F2, SERPINC1
5kaolin4410.2F2, F8, F5, APOH
6inogatran4410.2F5, F2, SERPINC1
7bivalirudin44 1111.2SERPINC1, SELP, F2, F5
8acenocoumarol44 49 1112.2F2, F5, CYP2C9, VKORC1
9argatroban44 1111.2SELP, SERPINC1, F2, F5
10hydroxyethyl starch4410.1F2, F8, SERPINC1, SELP
11phenprocoumon44 49 1112.1SERPINC1, VKORC1, F2, CYP2C9
12Drotrecogin alfa1110.1F5, F8, PROS1, F2
13ristocetin4410.1F5, F8, SELP, SERPINC1, F2
14aspartate4410.1F8, JAK2, AFP, ABCB7, F2
15hirugen4410.1F5, SERPINC1, F2
16coumarin44 2 49 2413.1VKORC1, F5, CYP2C9, SERPINC1, F2
17uric acid44 2411.1ABCB7, AFP, F5, APOH, TTF2
18dextran sulfate4410.0F5, JAK2, APOH, SELP
19gamma-carboxyglutamic acid4410.0F5, VKORC1, PROS1, F2
20hirudin4410.0THPO, SERPINC1, SELP, F2, F5, F8
21ticlopidine44 1111.0SELP, APOH, SERPINC1, CYP2C9
22desmopressin44 59 28 1112.9F5, F2, SELP, SERPINC1, F8, REN
23dexamethasone44 49 28 1112.9REN, CYP2C9, PROS1, F8, AFP
24warfarin44 49 11 2412.8SELP, SERPINC1, TTF2, APOH, VKORC1, CYP2C9
25kininogen449.8SERPINC1, F2, REN, F5, APOH, SELP
26polyethylene glycol449.8F8, F5, IFNA2, AFP, F2, THPO
27sialic acid449.7AFP, APOH, ABCB7, F8, SELP, THPO
28homocysteine44 2410.7APOH, SELP, F5, F8, SERPINC1, F2
29carboplatin44 49 1111.6MTHFR, IFNA2, AFP, SST, THPO
30glucose449.6TTF2, CYP2C9, PROS1, APOH, IFNA2, REN
31vitamin-e449.5PROS1, ABCB7, F5, JAK2, IFNA2
32diltiazem44 28 1111.5REN, CYP2C9, SERPINC1, F2
335fluorouracil449.4THPO, CYP2C9, SST, MTHFR, IFNA2, IFNAR2
34cyclophosphamide44 49 1111.4F8, MTHFR, F5, IFNA2, APOH, AFP
35lactate449.4ABCB7, F2, F5, AFP, F8, APOH
36progesterone44 59 28 11 2413.3F8, IFNA2, F5, AFP, CYP2C9, ABCB7
37heparin44 28 11 2412.3THPO, TTF2, ABCB7, AFP, PROS1, MTHFR
38prostacyclin449.2SELP, THPO, APOH, F8, F5, PROS1
39fibrinogen449.2APOH, F8, F5, AFP, ABCB7, F2
40cyclosporin a44 28 5911.1JAK2, TTF2, SELP, F8, MTHFR, CYP2C9
41nitric oxide44 11 2411.1THPO, CYP2C9, F5, JAK2, APOH, F8
42testosterone44 59 11 2412.1AFP, ABCB7, PROS1, MTHFR, SST, F5
43aspirin44 49 28 2412.1JAK2, F5, MTHFR, CYP2C9, F2, TTF2
44alanine448.9SERPINC1, ABCB7, THPO, TTF2, IFNAR2, F2
45retinoic acid44 249.9MTHFR, AFP, IFNA2, SST, CYP2C9, THPO
46epinephrine44 11 2410.9F8, SELP, JAK2, F5, AFP, SST
47steroid448.8JAK2, CYP2C9, AFP, PROS1, F5, F8
48cholesterol44 28 11 2411.7JAK2, APOH, F8, F5, SELP, TTF2
49creatinine448.7SERPINC1, SELP, THPO, TTF2, F2, ABCB7
50vegf448.5SERPINC1, SELP, F5, TTF2, REN, SST

GO Terms for genes affiliated with Portal Vein Thrombosis

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16Gene Ontology
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Cellular components related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.9PROS1, F5, F8
2extracellular regionGO:0055768.5IFNAR2, IFNA2, F8, F5, PROS1, SST
3extracellular spaceGO:0056158.2SERPINC1, IFNAR2, IFNA2, APOH, F8, F5

Biological processes related to Portal Vein Thrombosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:03019410.2F2, APOH
2blood coagulation, intrinsic pathwayGO:00759710.1F2, F8, APOH
3peptidyl-glutamic acid carboxylationGO:01718710.1F2, PROS1, VKORC1
4positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.9JAK2, F2, SELP
5platelet degranulationGO:0025769.9F8, F5, PROS1, SELP
6negative regulation of fibrinolysisGO:0519189.9F2, APOH
7cell surface receptor signaling pathwayGO:0071669.7IFNAR2, IFNA2, SST, F2
8platelet activationGO:0301689.6F8, F5, PROS1, F2, THPO, SELP
9cellular protein metabolic processGO:0442679.4RPL36, VKORC1, PROS1, REN, F2
10blood coagulationGO:0075969.1SERPINC1, IFNA2, F8, JAK2, F5, PROS1

Products for genes affiliated with Portal Vein Thrombosis

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  • Antibodies
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Sources for Portal Vein Thrombosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet