MCID: PST095
MIFTS: 36

Post-Thrombotic Syndrome malady

Cardiovascular diseases, Blood diseases categories

Summaries for Post-Thrombotic Syndrome

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Disease Ontology:9 A venous insufficiency that is characterized by aching pain, heaviness, swelling, cramps, itching, or tingling in the affected limb and is a chronic complication of deep venous thrombosis.

MalaCards based summary: Post-Thrombotic Syndrome, also known as postphlebitic syndrome, is related to thrombophlebitis and thrombophilia. An important gene associated with Post-Thrombotic Syndrome is F8 (coagulation factor VIII, procoagulant component), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The compounds rfviii and inogatran have been mentioned in the context of this disorder. Affiliated tissues include endothelial.

Wikipedia:63 Post-thrombotic syndrome (PTS, also called postphlebitic syndrome and venous stress disorder) is the... more...

Aliases & Classifications for Post-Thrombotic Syndrome

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Post-Thrombotic Syndrome, Aliases & Descriptions:

Name: Post-Thrombotic Syndrome 9
Postphlebitic Syndrome 9 43 60
Postphlebetic Syndrome with Inflammation 9 60
 
Postphlebetic Syndrome with Ulcer 9 60
Postphlebetic Syndrome with Ulcer and Inflammation 9
Venous Stress Disorder 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


External Ids:

Disease Ontology9 DOID:2364
MeSH33 D011186
ICD9CM27 459.1
ICD1025 I87.0

Related Diseases for Post-Thrombotic Syndrome

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Diseases related to Post-Thrombotic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophlebitis31.0F8
2thrombophilia30.3F2, F8, F5
3factor xii deficiency10.4F5
4central retinal vein occlusion10.4F5
5factor xiii deficiency10.4F5
6homocysteinemia10.4F5
7varicose veins10.3
8venous insufficiency10.3
9factor viii deficiency10.2F8, F5
10factor v and factor viii, combined deficiency of10.1F8, F5
11arteriovenous fistula10.1
12lipodermatosclerosis10.1
13pulmonary hypertension10.1
14chronic venous leg ulcers10.1
15lymphedema10.1
16reflex sympathetic dystrophy10.1
17vascular disease10.1
18endotheliitis10.1
19chronic thromboembolic pulmonary hypertension10.1
20intracranial thrombosis10.1F8, F5
21hypoprothrombinemia10.0F2, F5
22factor x deficiency10.0F2, F5
23blood protein disease10.0F2, F5
24thrombophilia due to antithrombin iii deficiency10.0F2, F5
25dysfibrinogenemia10.0F5, F2
26hemophilia b10.0F2, F8
27placental abruption10.0F2, F5
28scott syndrome10.0F2, F5
29vitamin k deficiency hemorrhagic disease10.0F2, F8
30protein c deficiency10.0F2, F5
31pulmonary embolism10.0F5, F2
32pregnancy loss, recurrent 110.0F5, F2
33galactosemia10.0F2, F5
34von willebrand's disease10.0F2, F8
35hepatitis a10.0F8, F2
36stroke, ischemic10.0F2, F5
37bernard-soulier syndrome, type c10.0F8, F2
38lupus erythematosus10.0F5, F2
39liver disease9.9F5, F2
40viral hepatitis9.9F8, F2
41hypertension, essential9.9F5, F2
42congenital heart disease9.9F2, F8
43hepatitis9.9F2, F8
44hepatitis b9.8F8, F2
45systemic lupus erythematosus9.8F8, F2
46myocardial infarction9.8F5, F8
47factor v deficiency9.8F5, F8, F2
48portal vein thrombosis9.8F2, F8, F5
49factor xi deficiency, autosomal recessive9.8F2, F8, F5
50protein s deficiency9.8F2, F8, F5

Graphical network of the top 20 diseases related to Post-Thrombotic Syndrome:



Diseases related to post-thrombotic syndrome

Symptoms for Post-Thrombotic Syndrome

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Drugs & Therapeutics for Post-Thrombotic Syndrome

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Drug clinical trials:

Search ClinicalTrials for Post-Thrombotic Syndrome

Search NIH Clinical Center for Post-Thrombotic Syndrome

Genetic Tests for Post-Thrombotic Syndrome

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Anatomical Context for Post-Thrombotic Syndrome

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MalaCards organs/tissues related to Post-Thrombotic Syndrome:

31
Endothelial

Animal Models for Post-Thrombotic Syndrome or affiliated genes

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Publications for Post-Thrombotic Syndrome

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Articles related to Post-Thrombotic Syndrome:

(show all 44)
idTitleAuthorsYear
1
Diagnosis of deep vein thrombosis, and prevention of deep vein thrombosis recurrence and the post-thrombotic syndrome in the primary care medicine setting anno 2014. (25685720)
2015
2
Prevalence of post-thrombotic syndrome after cardiac catheterization. (25663038)
2015
3
Low incidence of post-thrombotic syndrome in patients treated with new oral anticoagulants and percutaneous endovenous intervention for lower extremity deep venous thrombosis. (25832599)
2015
4
Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: a cohort study. (25528070)
2015
5
Inflammation markers and their trajectories after deep vein thrombosis in relation to risk of post-thrombotic syndrome. (25495610)
2015
6
Long-term increased factor VIII levels are associated to interleukin-6 levels but not to post-thrombotic syndrome in patients with deep venous thrombosis. (25575413)
2015
7
Prevention and treatment of the post-thrombotic syndrome and of the chronic thromboembolic pulmonary hypertension. (25577951)
2015
8
Successful treatment of post thrombotic syndrome with sequential lumbar sympathetic block. (25675072)
2015
9
Quality-of-life in interventionally treated patients with post-thrombotic syndrome. (25729074)
2015
10
Percutaneous pharmacomechanical thrombectomy offers lower risk of post-thrombotic syndrome than catheter-directed thrombolysis in patients with acute deep vein thrombosis of the lower limb. (25765634)
2015
11
Residual vein thrombosis and onset of post-thrombotic syndrome: influence of the 4G/5G polymorphism of plasminogen activator inhibitor-1 gene. (24485402)
2014
12
The IDEAL DVT study, individualised duration elastic compression therapy against long-term duration of therapy for the prevention of post-thrombotic syndrome: protocol of a randomised controlled trial. (25190617)
2014
13
Biomarkers for post thrombotic syndrome: a case-control study. (24975586)
2014
14
Compression stockings to prevent post-thrombotic syndrome. (25016991)
2014
15
Health-related quality of life in children and young adults with post-thrombotic syndrome: results from a cross-sectional study. (24347376)
2014
16
Elastic compression stockings fail to prevent post-thrombotic syndrome after a first deep vein thrombosis. (24938301)
2014
17
The post-thrombotic syndrome and compression therapy. (24843092)
2014
18
Re: 'The post-thrombotic syndrome and compression therapy' by van der Velden etA al. (25005694)
2014
19
The predictive value of markers of fibrinolysis and endothelial dysfunction in the post thrombotic syndrome. A systematic review. (24500187)
2014
20
Short-term follow-up of Quality-of-Life in interventionally treated patients with post-thrombotic syndrome after deep venous occlusion. (24843095)
2014
21
Association between thrombophilia and the post-thrombotic syndrome: a systematic review and meta-analysis. (24406063)
2014
22
Impact of graduated compression stockings on the prevention of post-thrombotic syndrome - results of a randomized controlled trial. (25059736)
2014
23
Efficacy of a short course of complex lymphedema therapy or graduated compression stocking therapy in the treatment of post-thrombotic syndrome. (24558028)
2014
24
Compression stockings to prevent post-thrombotic syndrome. (25016992)
2014
25
Post-thrombotic syndrome is an independent determinant of health-related quality of life following both first proximal and distal deep vein thrombosis. (24441147)
2014
26
Post-thrombotic syndrome after central venous catheter removal in childhood cancer survivors: A prospective cohort study. (25359689)
2014
27
Compression stockings to prevent post-thrombotic syndrome - Authors' reply. (25016993)
2014
28
Vascular Disease Patient Information Page: The post-thrombotic syndrome. (25047858)
2014
29
D-dimer, FVIII and thrombotic burden in the acute phase of deep vein thrombosis in relation to the risk of post-thrombotic syndrome. (24968959)
2014
30
Compression stockings to prevent post-thrombotic syndrome: a randomised placebo-controlled trial. (24315521)
2014
31
Predictors of post-thrombotic syndrome in a population with a first deep vein thrombosis and no primary venous insufficiency. (23279046)
2013
32
Association between Thrombophilia and the Post-Thrombotic Syndrome. (23762560)
2013
33
Effect of long-term LMWH on post-thrombotic syndrome in patients with iliac/noniliac venous thrombosis: a subanalysis from the home-LITE study. (23520150)
2013
34
Prevalence and predictors for post-thrombotic syndrome 3 to 16 years after pregnancy-related venous thrombosis: a population-based, cross-sectional, case-control study. (22452811)
2012
35
Extrinsic compression of left iliac vein does not predict the development of post thrombotic syndrome in left side deep venous thrombosis. (22708099)
2012
36
The future of deep venous thrombosis and post-thrombotic syndrome in 2020. (22312074)
2012
37
Definition of post-thrombotic syndrome following lower extremity deep venous thrombosis and standardization of outcome measurement in pediatric clinical investigations. (22482118)
2012
38
VenorutonAr: post thrombotic syndrome. Clinical improvement in venous insufficiency (signs and symptoms) with VenorutonAr. A five-year, open-registry, efficacy study. (22108472)
2011
39
Thrombophilia in patients with chronic venous leg ulcers-a study on patients with or without post-thrombotic syndrome. (21392126)
2011
40
Thrombophilia and the risk of post-thrombotic syndrome: retrospective cohort observation. (19874465)
2010
41
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. (19363611)
2009
42
Levels of inflammatory markers and the development of the post-thrombotic syndrome. (19277412)
2009
43
Risk factors for post-thrombotic syndrome in patients with a first deep venous thrombosis. (18983518)
2008
44
Familial elevated factor VIII in children with symptomatic venous thrombosis and post-thrombotic syndrome: results of a multicenter study. (16709943)
2006

Variations for Post-Thrombotic Syndrome

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Expression for genes affiliated with Post-Thrombotic Syndrome

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Search GEO for disease gene expression data for Post-Thrombotic Syndrome.

Pathways for genes affiliated with Post-Thrombotic Syndrome

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Compounds for genes affiliated with Post-Thrombotic Syndrome

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Compounds related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1rfviii439.7F8, F5
2inogatran439.6F5, F2
3cacl2439.6F8, F5
4ecarin439.5F5, F2
5hirugen439.5F5, F2
6spectrozyme439.5F5, F2
7danaparoid439.5F2, F5
8batroxobin439.5F2, F5
9monoethylglycinexylidide439.5F5, F2
10ximelagatran43 1210.5F2, F5
11ancrod439.5F5, F2
12heparinoids439.5F5, F2
13fondaparinux439.5F5, F2
14acenocoumarol43 49 1211.5F2, F5
15hind iii439.5F8, F5
16bivalirudin43 1210.5F2, F5
17argatroban43 1210.5F5, F2
18deae-sephadex a-50439.5F2, F8
19coumarins439.5F5, F2
20desogestrel43 1210.5F2, F5
21protamine sulfate439.4F5, F2
22methylene439.4F8, F5
23gestodene43 1210.4F5, F2
24ofloxacin43 2 1211.4F2, F5
25hydroxyethyl starch439.3F2, F8
26penicillin439.3F2, F5
27antipyrine43 1210.3F2, F5
28tranexamic acid43 1210.3F2, F8
29gamma-carboxyglutamic acid439.2F5, F2
30cyproteroneacetate439.0F5, F2
31kaolin439.0F8, F2, F5
32ristocetin439.0F2, F8, F5
33desmopressin43 59 28 1212.0F8, F2, F5
34cardiolipin43 1210.0F2, F8, F5
35hirudin439.0F2, F8, F5
36phosphatidylethanolamine43 129.9F2, F8, F5
37warfarin43 49 24 1211.9F5, F2, F8
38acetaminophen43 2 49 24 1212.9F2, F8, F5
39polyethylene glycol438.9F2, F5, F8
40homocysteine43 249.9F5, F8, F2
41citrate438.9F2, F8, F5
42phosphatidylserine43 28 1210.9F5, F8, F2
43phosphatidylcholine438.9F2, F8, F5
44aspirin43 49 28 2411.9F2, F5, F8
45epinephrine43 24 1210.9F2, F8, F5
46levonorgestrel43 59 28 1211.8F2, F5
47fibrinogen438.8F8, F2, F5
48phospholipid438.8F5, F2, F8
49lactate438.5F5, F2, F8
50creatinine438.5F2, F8, F5

GO Terms for genes affiliated with Post-Thrombotic Syndrome

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Cellular components related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.2F5, F8
2extracellular regionGO:00055768.5F5, F8, F2
3extracellular spaceGO:00056158.2F5, F8, F2

Biological processes related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00025769.3F8, F5
2blood coagulation, intrinsic pathwayGO:00075979.0F2, F8
3acute-phase responseGO:00069538.7F2, F8
4platelet activationGO:00301688.6F2, F8, F5
5blood coagulationGO:00075968.4F2, F8, F5

Molecular functions related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.3F5, F8
2serine-type endopeptidase activityGO:00042528.2F5, F8, F2

Products for genes affiliated with Post-Thrombotic Syndrome

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Sources for Post-Thrombotic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet