MCID: PST095
MIFTS: 47

Post-Thrombotic Syndrome malady

Categories: Cardiovascular diseases, Blood diseases

Aliases & Classifications for Post-Thrombotic Syndrome

Aliases & Descriptions for Post-Thrombotic Syndrome:

Name: Post-Thrombotic Syndrome 12 14
Postphlebitic Syndrome 12 52 42 69
Postphlebetic Syndrome with Ulcer and Inflammation 12
Postphlebetic Syndrome with Inflammation 12
Postphlebetic Syndrome with Ulcer 12
Postthrombotic Syndrome 69
Venous Stress Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2364
ICD10 33 I87.0
MeSH 42 D011186

Summaries for Post-Thrombotic Syndrome

Disease Ontology : 12 A venous insufficiency that is characterized by aching pain, heaviness, swelling, cramps, itching, or tingling in the affected limb and is a chronic complication of deep venous thrombosis.

MalaCards based summary : Post-Thrombotic Syndrome, also known as postphlebitic syndrome, is related to chronic venous insufficiency and thrombosis. An important gene associated with Post-Thrombotic Syndrome is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Heparin and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 71 Post-thrombotic syndrome (PTS), also called postphlebitic syndrome and venous stress disorder is a... more...

Related Diseases for Post-Thrombotic Syndrome

Diseases related to Post-Thrombotic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
id Related Disease Score Top Affiliating Genes
1 chronic venous insufficiency 11.0
2 thrombosis 10.4
3 acrodysplasia with ossification abnormalities, short stature and fibular hypoplasia 10.2 F5 F8
4 erythrocytosis, familial, 4 10.2 F5 F8
5 acrodysplasia scoliosis 10.2 F5 F8
6 latent syphilis 10.2 ICAM1 IL6
7 alpha-2-macroglobulin deficiency 10.2 F2 F8
8 dyskinetic cerebral palsy 10.2 F2 F8
9 social phobia 10.2 F2 F8
10 vaginal endometrial stromal tumor 10.2 ICAM1 IL6
11 bladder hepatoid adenocarcinoma 10.2 F5 F8
12 multiple mitochondrial dysfunctions syndrome 10.2 F8 IL6
13 autonomic neuropathy 10.2 F2 F8
14 congenital insensitivity to pain with severe intellectual disability 10.2 F2 F5
15 oxyphilic adenoma 10.2 F2 F5
16 hendra virus infection 10.2 F2 F5
17 conduct disorder 10.1 ICAM1 IL6
18 myosclerosis, congenital 10.1 F5 SERPINC1
19 photosensitive epilepsy 10.1 F2 F5
20 miller-dieker lissencephaly syndrome 10.1 F2 SERPINC1
21 influenza 10.1 F2 SERPINC1
22 multilocular clear cell renal cell carcinoma 10.1 ICAM1 IL6
23 neuronopathy, distal hereditary motor, type iid 10.1 F5 SERPINC1
24 mixed epithelial tumor of ovary 10.1 F2 SERPINC1
25 infiltrating ureter transitional cell carcinoma 10.1 F2 F8
26 chorioretinal scar 10.1 F2 SERPINC1
27 absence of innominate vein 10.1 F5 SERPINE1
28 mixed hepatoblastoma 10.1 F2 SERPINC1
29 peanut allergy 10.1 F2 SERPINC1
30 may-hegglin anomaly 10.1 F2 SERPINC1
31 aminoaciduria 10.1 F5 SERPINE1
32 dmd-related dilated cardiomyopathy 10.1 F2 SERPINC1
33 spinal cord lipoma 10.1 F2 SERPINC1
34 schwannoma of jugular foramen 10.1 F2 SERPINC1
35 cerebellar astrocytoma 10.1 F2 SERPINC1
36 houlston ironton temple syndrome 10.1 F2 F5
37 angelucci's syndrome 10.1 F2 SERPINC1
38 ductal carcinoma in situ 10.1 F2 SERPINC1
39 central congenital hypothyroidism 10.1 F5 SERPINE1
40 brazilian hemorrhagic fever 10.1 SERPINC1 SERPINE1
41 microphthalmia, isolated, with coloboma 10 10.1 F5 SERPINE1
42 spinocerebellar ataxia 27 10.1 F2 F8
43 ovarian papillary cystadenoma 10.1 F2 SERPINC1
44 cutaneous candidiasis 10.1 CCL2 ICAM1
45 epstein-barr virus hepatitis 10.1 F2 SERPINC1
46 glutathionuria 10.1 F2 SERPINE1
47 schwannoma of ureter 10.1 CCL2 IL6
48 nodular prostate 10.1 ICAM1 IL6
49 stroke, ischemic 10.1 F2 F5 F8
50 hypertrichosis 10.1 F5 F8 SERPINC1

Comorbidity relations with Post-Thrombotic Syndrome via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease
Hypertension, Essential Ischemic Heart Disease
Peripheral Vascular Disease Venous Insufficiency

Graphical network of the top 20 diseases related to Post-Thrombotic Syndrome:



Diseases related to Post-Thrombotic Syndrome

Symptoms & Phenotypes for Post-Thrombotic Syndrome

MGI Mouse Phenotypes related to Post-Thrombotic Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 SERPINC1 SERPINE1 F2 F5 ICAM1 IL6
2 homeostasis/metabolism MP:0005376 9.8 F2 F5 F8 ICAM1 IL6 SERPINC1
3 immune system MP:0005387 9.7 CCL2 F2 F8 ICAM1 IL6 SERPINC1
4 integument MP:0010771 9.35 F2 F5 ICAM1 IL6 SERPINE1
5 mortality/aging MP:0010768 9.17 F2 F5 F8 ICAM1 IL6 SERPINC1

Drugs & Therapeutics for Post-Thrombotic Syndrome

Drugs for Post-Thrombotic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 9005-49-6 772 46507594
2
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
3
Dalteparin Approved Phase 4,Phase 3 9041-08-1
4
Glucosamine Approved, Nutraceutical Phase 4,Early Phase 1 3416-24-8 439213
5 calcium heparin Phase 4,Phase 3
6 Heparin, Low-Molecular-Weight Phase 4,Phase 3
7 Anesthetics Phase 4,Phase 2
8 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
9 Fibrinolytic Agents Phase 4,Phase 3
10 Anticoagulants Phase 4,Phase 3,Phase 1,Phase 2
11 Glucuronyl glucosamine glycan sulfate Phase 4
12 Hypoglycemic Agents Phase 4
13 Hypolipidemic Agents Phase 4,Phase 1,Phase 2
14 Lipid Regulating Agents Phase 4,Phase 1,Phase 2
15 Antimetabolites Phase 4,Phase 1,Phase 2
16
Warfarin Approved Phase 3,Phase 1,Phase 2 81-81-2 6691 54678486
17 Nadroparin Approved Phase 3 9041-08-1
18
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
19
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
20
Tenecteplase Approved Phase 3 191588-94-0
21 tannic acid Approved, Nutraceutical Phase 3
22
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
23
Phytonadione Approved, Nutraceutical Phase 3 84-80-0 4812 5284607
24 Thrombin Phase 3,Phase 2
25
protease inhibitors Phase 3
26 Serine Proteinase Inhibitors Phase 3
27 Coagulants Phase 3
28 HIV Protease Inhibitors Phase 3
29 Hemostatics Phase 3
30 Factor Xa Inhibitors Phase 3
31 Antithrombin III Phase 3
32 Antithrombins Phase 3
33 Calcium, Dietary Phase 3,Phase 2,Phase 1
34 Tissue Plasminogen Activator Phase 3
35 Vitamins Phase 3,Phase 2
36 Plasminogen Phase 3
37 Dabigatran Phase 3
38 Immunoglobulins Phase 3
39 Antibodies Phase 3
40 Antibodies, Antiphospholipid Phase 3
41 serine Nutraceutical Phase 3
42 Kava Nutraceutical Phase 3 9000-38-8
43 naphthoquinone Nutraceutical Phase 3
44 Vitamin K Nutraceutical Phase 3
45 Menaquinone Nutraceutical Phase 3
46
Methyl salicylate Approved, Vet_approved Phase 2 119-36-8 4133
47
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
48
Pyridoxal Approved, Nutraceutical Phase 2 66-72-8 1050
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
50 Peripheral Nervous System Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 134)
id Name Status NCT ID Phase
1 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
2 Global Vascular Effects of Intermittent Pneumatic Compression-Pilot Study Unknown status NCT01064323 Phase 4
3 Two Weeks of Low Molecular Weight Heparin for Distal Vein Thrombosis Unknown status NCT01252420 Phase 4
4 OASIS Wound Matrix (Oasis) Mechanism of Action Completed NCT00570141 Phase 4
5 Practicability of Gliding Aids for Medical Compression Stockings Completed NCT01432795 Phase 4
6 DermACELL in Subjects With Chronic Wounds of the Lower Extremities Completed NCT01970163 Phase 4
7 Wound Fluid Protease Levels During Use of Novel Wound Dressing Completed NCT01567150 Phase 4
8 Skin Ulcers Treatment With an Handicraft Topical Device Completed NCT02512159 Phase 4
9 Prospective Evaluation of the QoL of Patients With PTS Who Receive Compression Therapy and Sulodexide Recruiting NCT02512601 Phase 4
10 Outcome of Percutaneous Mechanical Thrombectomy to Treat Acute Deep Venous Thrombosis Recruiting NCT02959801 Phase 4
11 Juxta-CuresTM Versus Bandaging for Venous Ulcers Recruiting NCT02790593 Phase 4
12 Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT) Recruiting NCT02470806 Phase 4
13 Flexitouch Compression System for Venous Stasis Ulcer Terminated NCT00534937 Phase 4
14 Flexitouch Treatment for Venous Ulcers Terminated NCT00847002 Phase 4
15 Pulsed Electromagnetic Fields (PEMF) and Post-Axillary Surgery Morbidity Terminated NCT01255631 Phase 4
16 Treatment Trial for Post-Thrombotic Syndrome Unknown status NCT00633971 Phase 3
17 Randomized Controlled Trial of Anticoagulation vs. Placebo for a First Symptomatic Isolated Distal Deep-vein Thrombosis (IDDVT) Unknown status NCT00421538 Phase 3
18 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2 Unknown status NCT01737762 Phase 3
19 Evaluation of a Venous-Return Assist Device (Venowave) to Treat Post-Thrombotic Syndrome: A Randomized Controlled Trial Completed NCT00182208 Phase 3
20 The SOX Trial: Compression Stockings to Prevent the Post-Thrombotic Syndrome Completed NCT00143598 Phase 3
21 Biomarker Sub Study of the Compression Stockings to Prevent the Post-Thrombotic Syndrome (SOX) Trial Completed NCT01615705 Phase 3
22 Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Completed NCT00790335 Phase 3
23 Full-Leg vs Below-Knee Elastic Stockings for Prevention of the Post-Thrombotic Syndrome Completed NCT00426075 Phase 3
24 Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities Completed NCT00628576 Phase 3
25 Observational Study Providing 12 Months of Safety Follow-Up From First Exposure to HP802-247 Completed NCT01970657 Phase 3
26 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers Completed NCT01656889 Phase 3
27 Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers Completed NCT00909870 Phase 3
28 Elastic Compression Stockings for Prevention of Post-thrombotic Syndrome Recruiting NCT01578122 Phase 3
29 DUTCH CAVA-trial: CAtheter Versus Anticoagulation Alone for Acute Primary (Ilio)Femoral DVT. Recruiting NCT00970619 Phase 3
30 Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum Recruiting NCT02802995 Phase 3
31 Evaluation of the Duration of Therapy for Thrombosis in Children Recruiting NCT00687882 Phase 3
32 Safety of Dabigatran Etexilate in Blood Clot Prevention in Children Recruiting NCT02197416 Phase 3
33 Open Label Study Comparing Efficacy and Safety of Dabigatran Etexilate to Standard of Care in Paediatric Patients With Venous Thromboembolism (VTE) Recruiting NCT01895777 Phase 3
34 Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial Not yet recruiting NCT02767232 Phase 3
35 Clinical Trial of ECLIPSE PRP™ Wound Biomatrix in Chronic Non-Healing Venous Leg Ulcers Not yet recruiting NCT02312518 Phase 2, Phase 3
36 EVENT: Hydrotherapy and Deep Venous Thrombosis Terminated NCT00348907 Phase 3
37 Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers Terminated NCT01853384 Phase 3
38 Clot Dissolving Treatment for Blood Clots in the Lungs Terminated NCT00680628 Phase 3
39 Efficacy of Sodium Heparin in Prophylaxis of Venous Thromboembolism in Surgical Patients Withdrawn NCT00912483 Phase 3
40 Enoxaparin in Children With Asymptomatic Venous Thrombosis After Pediatric Cardiac Surgery Withdrawn NCT01474902 Phase 3
41 The Use of Intermittent Pneumatic Compression Device for Symptomatic Relief in Patients With Post Thrombotic Syndrome Unknown status NCT01637428 Phase 2
42 Laparoscopic Bariatric Surgery: Two Regimens of Venous Thromboprophylaxis: Prospective Randomized Study Unknown status NCT02128178 Phase 1, Phase 2
43 Study of Thymosin Beta 4 in Patients With Venous Stasis Ulcers Completed NCT00832091 Phase 2
44 Pilot Study for VeinoPlus to Improve Symptoms of Postthrombotic Syndrome Completed NCT00858130 Phase 2
45 Dose Finding Study of HP802-247 in Venous Leg Ulcers Completed NCT00852995 Phase 2
46 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
47 The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency Completed NCT02498327 Phase 2
48 Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers Recruiting NCT02742844 Phase 1, Phase 2
49 Statin Use in Patients With Acute VTE Recruiting NCT02331095 Phase 1, Phase 2
50 StAtins for Venous Event Reduction in Patients With Venous Thromboembolism Pilot Study Recruiting NCT02679664 Phase 2

Search NIH Clinical Center for Post-Thrombotic Syndrome

Cochrane evidence based reviews: postphlebitic syndrome

Genetic Tests for Post-Thrombotic Syndrome

Anatomical Context for Post-Thrombotic Syndrome

MalaCards organs/tissues related to Post-Thrombotic Syndrome:

39
Endothelial

Publications for Post-Thrombotic Syndrome

Articles related to Post-Thrombotic Syndrome:

(show top 50) (show all 91)
id Title Authors Year
1
Predictors for the development of post-thrombotic syndrome in patients with primary lower limb deep venous thrombosis: A case-control study. ( 27083699 )
2016
2
Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel. ( 27247235 )
2016
3
Impact of optimal anticoagulation therapy on chronic venous ulcer healing in thrombophilic patients with post-thrombotic syndrome. ( 27974007 )
2016
4
The post-thrombotic syndrome. ( 27913509 )
2016
5
Predictors of the post-thrombotic syndrome and their effect on the therapeutic management of deep vein thrombosis. ( 27639012 )
2016
6
One versus two years of elastic compression stockings for prevention of post-thrombotic syndrome (OCTAVIA study): randomised controlled trial. ( 27245485 )
2016
7
Understanding the barriers in compliance to elastic compression garments in the treatment of pediatric post-thrombotic syndrome: A qualitative study. ( 27318248 )
2016
8
Stockings to prevent post-thrombotic syndrome. ( 27245828 )
2016
9
The role of inflammation in post-thrombotic syndrome after pregnancy-related deep vein thrombosis: A population-based, cross-sectional study. ( 26826503 )
2016
10
Post-thrombotic syndrome after catheter-directed thrombolysis for deep vein thrombosis (CaVenT): 5-year follow-up results of an open-label, randomised controlled trial. ( 26853645 )
2016
11
Post-thrombotic syndrome and other outcomes of lower extremity deep vein thrombosis in children. ( 27474755 )
2016
12
Post-thrombotic syndrome and the risk of subsequent recurrent thromboembolism. ( 26986754 )
2016
13
Efficacy of compression for the prevention of post-thrombotic syndrome: an unsolved clinical conundrum Comment on Burgstaller et al, p. 141 - 147. ( 27058794 )
2016
14
Post-thrombotic syndrome. ( 27209458 )
2016
15
Post-thrombotic syndrome and venous disease-specific quality of life in patients with vascular BehAset's disease. ( 27318049 )
2016
16
Time taken to the maximum increase in the oxygenated hemoglobin level in calf muscle as a predictor of mild and moderate post-thrombotic syndrome. ( 27638999 )
2016
17
Statins for the prevention of post-thrombotic syndrome in patients with deep vein thrombosis. Comment on San Norberto et al, p. 133 - 140. ( 27058793 )
2016
18
Collateral circulation in pediatric post-thrombotic syndrome. ( 27404004 )
2016
19
Efficacy of compression stockings in preventing post-thrombotic syndrome in patients with deep venous thrombosis: a systematic review and metaanalysis. ( 27058800 )
2016
20
Oral anticoagulants, effect on thrombus resolution and post-thrombotic syndrome. ( 26916765 )
2016
21
Prevention of the Post-Thrombotic Syndrome. ( 27311456 )
2016
22
Post-thrombotic syndrome in patients treated with rivaroxaban or enoxaparin/vitamin K antagonists for acute deep-vein thrombosis. A post-hoc analysis. ( 27583311 )
2016
23
Toll-like receptor 9 gene expression in the post-thrombotic syndrome, residual thrombosis and recurrent deep venous thrombosis: A case-control study. ( 26938157 )
2016
24
High rate of inter-observer agreement between professional-rated scores of the Villalta scale for the assessment of the post-thrombotic syndrome. ( 27392138 )
2016
25
Deep vein thrombosis resolution, recurrence and post-thrombotic syndrome: a prospective observational study protocol. ( 27651905 )
2016
26
Systematic Review and Meta-Analysis of Utility of Graduated Compression Stockings in Prevention of Post-Thrombotic Syndrome. ( 27026391 )
2016
27
Post Thrombotic Syndrome. ( 27628001 )
2016
28
Outcomes of Stent Placement for Chronic Occlusion of a Filter-bearing Inferior Vena Cava in Patients with Severe Post-thrombotic Syndrome. ( 27751714 )
2016
29
Pediatric post-thrombotic syndrome in children: Toward the development of a new diagnostic and evaluative measurement tool. ( 27393923 )
2016
30
Relationship between development of post-thrombotic syndrome and serial ultrasound, D-dimer, and factor VIII activity after a first deep venous thrombosis. ( 26946892 )
2016
31
Guidance for the prevention and treatment of the post-thrombotic syndrome. ( 26780743 )
2016
32
Inter-rater agreement between professional-rated and patient-rated scores of the Villalta scale for evaluation of the post-thrombotic syndrome. ( 27058275 )
2016
33
Effect of compression stockings on post thrombotic syndrome in patients with deep vein thrombosis: a meta-analysis of randomised controlled trials. ( 27264039 )
2016
34
Novel perspectives on diagnosis and clinical significance of the post-thrombotic syndrome in children. ( 27677803 )
2016
35
Clot structure and fibrinolytic potential in patients with post thrombotic syndrome. ( 26589270 )
2016
36
Prevalence and risk factors for post thrombotic syndrome after deep vein thrombosis in children: a cohort study. ( 25528070 )
2015
37
Rutosides for treatment of post-thrombotic syndrome. ( 26376212 )
2015
38
Prevalence of post-thrombotic syndrome after cardiac catheterization. ( 25663038 )
2015
39
The post thrombotic syndrome: Ignore it and it will come back to bite you. ( 26462885 )
2015
40
Successful treatment of post thrombotic syndrome with sequential lumbar sympathetic block. ( 25675072 )
2015
41
Inflammation markers and their trajectories after deep vein thrombosis in relation to risk of post-thrombotic syndrome. ( 25495610 )
2015
42
Role of coexisting contralateral primary venous disease in development of post-thrombotic syndrome following catheter-based treatment of iliofemoral deep venous thrombosis. ( 26992610 )
2015
43
Percutaneous pharmacomechanical thrombectomy offers lower risk of post-thrombotic syndrome than catheter-directed thrombolysis in patients with acute deep vein thrombosis of the lower limb. ( 25765634 )
2015
44
Low incidence of post-thrombotic syndrome in patients treated with new oral anticoagulants and percutaneous endovenous intervention for lower extremity deep venous thrombosis. ( 25832599 )
2015
45
Visceral obesity, but not metabolic syndrome, is associated with the presence of post-thrombotic syndrome. ( 26033396 )
2015
46
Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome). ( 26387733 )
2015
47
Excellent long-term results with iliac stenting in local anesthesia for post-thrombotic syndrome. ( 26445677 )
2015
48
Development and validation of a tool for patient reporting of symptoms and signs of the post-thrombotic syndrome. ( 26422814 )
2015
49
Quality-of-life in interventionally treated patients with post-thrombotic syndrome. ( 25729074 )
2015
50
Plasma MMP and TIMP evaluation in patients with deep venous thrombosis: could they have a predictive role in the development of post-thrombotic syndrome? ( 26403997 )
2015

Variations for Post-Thrombotic Syndrome

Expression for Post-Thrombotic Syndrome

Search GEO for disease gene expression data for Post-Thrombotic Syndrome.

Pathways for Post-Thrombotic Syndrome

Pathways related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

(show all 17)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 F2 F5 F8 SERPINC1 SERPINE1
2
Show member pathways
12.56 F2 F5 F8 SERPINC1
3
Show member pathways
11.89 CCL2 F2 ICAM1 IL6 SERPINE1
4 11.82 CCL2 ICAM1 SERPINE1
5 11.75 CCL2 ICAM1 IL6
6 11.71 CCL2 ICAM1 IL6
7 11.67 CCL2 ICAM1 IL6
8 11.56 CCL2 ICAM1 IL6
9
Show member pathways
11.56 F2 F5 F8 SERPINC1 SERPINE1
10 11.55 CCL2 ICAM1 IL6 SERPINE1
11 11.27 CCL2 ICAM1 IL6
12 11.23 CCL2 ICAM1 IL6
13 11.16 F2 F5 F8 SERPINC1 SERPINE1
14 11.11 ICAM1 IL6
15 11.09 CCL2 IL6
16 10.9 CCL2 F2 ICAM1
17 10.73 CCL2 ICAM1

GO Terms for Post-Thrombotic Syndrome

Cellular components related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL2 F2 F5 F8 IL6 SERPINC1
2 external side of plasma membrane GO:0009897 9.54 F2 ICAM1 IL6
3 platelet alpha granule lumen GO:0031093 9.43 F5 F8 SERPINE1
4 endoplasmic reticulum lumen GO:0005788 9.35 F2 F5 F8 IL6 SERPINC1
5 ER to Golgi transport vesicle GO:0030134 9.32 F5 F8
6 extracellular space GO:0005615 9.23 CCL2 F2 F5 F8 ICAM1 IL6

Biological processes related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

(show all 35)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.81 CCL2 ICAM1 IL6
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 CCL2 ICAM1 IL6
3 ER to Golgi vesicle-mediated transport GO:0006888 9.78 F2 F5 F8
4 cellular protein metabolic process GO:0044267 9.76 F2 F5 IL6 SERPINC1
5 platelet degranulation GO:0002576 9.75 F5 F8 SERPINE1
6 cellular response to tumor necrosis factor GO:0071356 9.73 CCL2 ICAM1 IL6
7 blood coagulation GO:0007596 9.73 F2 F5 F8 SERPINC1
8 response to wounding GO:0009611 9.69 CCL2 F2 IL6
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 ICAM1 IL6
10 cellular response to interleukin-1 GO:0071347 9.67 CCL2 ICAM1 IL6
11 monocyte chemotaxis GO:0002548 9.66 CCL2 IL6
12 cellular response to estradiol stimulus GO:0071392 9.66 CCL2 IL6
13 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.65 ICAM1 SERPINE1
14 response to bacterium GO:0009617 9.65 CCL2 IL6
15 response to antibiotic GO:0046677 9.65 CCL2 IL6
16 negative regulation of endothelial cell apoptotic process GO:2000352 9.64 ICAM1 SERPINE1
17 positive regulation of collagen biosynthetic process GO:0032967 9.63 CCL2 F2
18 regulation of blood coagulation GO:0030193 9.62 F2 SERPINC1
19 fibrinolysis GO:0042730 9.62 F2 SERPINE1
20 cellular response to interleukin-6 GO:0071354 9.61 CCL2 ICAM1
21 blood coagulation, intrinsic pathway GO:0007597 9.6 F2 F8
22 positive regulation of monocyte chemotaxis GO:0090026 9.59 CCL2 SERPINE1
23 positive regulation of blood coagulation GO:0030194 9.58 F2 SERPINE1
24 response to amino acid GO:0043200 9.58 CCL2 ICAM1 IL6
25 cellular response to nutrient levels GO:0031669 9.57 ICAM1 IL6
26 regulation of cell shape GO:0008360 9.56 CCL2 F2 ICAM1 IL6
27 negative regulation of fibrinolysis GO:0051918 9.55 F2 SERPINE1
28 positive regulation of cellular extravasation GO:0002693 9.54 CCL2 ICAM1
29 acute-phase response GO:0006953 9.54 F2 F8 IL6
30 acute inflammatory response to antigenic stimulus GO:0002438 9.52 ICAM1 SERPINC1
31 cellular response to dexamethasone stimulus GO:0071549 9.5 CCL2 ICAM1 IL6
32 regulation of vascular endothelial growth factor production GO:0010574 9.48 CCL2 IL6
33 cellular response to lipopolysaccharide GO:0071222 9.46 CCL2 ICAM1 IL6 SERPINE1
34 platelet activation GO:0030168 9.26 F2 F5 F8 IL6
35 hemostasis GO:0007599 8.92 F2 F5 F8 SERPINC1

Molecular functions related to Post-Thrombotic Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.33 F2 F5 F8
2 heparin binding GO:0008201 9.13 CCL2 F2 SERPINC1
3 receptor binding GO:0005102 8.92 CCL2 F2 IL6 SERPINE1

Sources for Post-Thrombotic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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