PTLD
MCID: PST046
MIFTS: 60

Post-Transplant Lymphoproliferative Disease (PTLD) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Post-Transplant Lymphoproliferative Disease

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65Wikipedia, 33MalaCards
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Wikipedia:65 Post-transplant lymphoproliferative disorder (PTLD) is the name given to a B-cell proliferation due to... more...

MalaCards: Post-Transplant Lymphoproliferative Disease, also known as post-transplant lymphoproliferative disorder, is related to hodgkin's lymphoma and tonsillitis. An important gene associated with Post-Transplant Lymphoproliferative Disease is IL10RA (interleukin 10 receptor, alpha), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Amyotrophic lateral sclerosis (ALS). The compounds cuprophan and rantes have been mentioned in the context of this disorder. Affiliated tissues include b cells, liver and lung, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Post-Transplant Lymphoproliferative Disease

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Sources:
43NIH Rare Diseases, 31LifeMap Discovery™, 49Orphanet, 62UMLS, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
posttransplant lymphoproliferative disease:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

post-transplant lymphoproliferative disease 43 31
post-transplant lymphoproliferative disorder 62
posttransplant lymphoproliferative disease 49
ptld 49


External Ids:

ICD10 via Orphanet26 D47.9
SNOMED-CT via Orphanet59 254290004, 450943001
UMLS via Orphanet63 C0432487

Related Diseases for Post-Transplant Lymphoproliferative Disease

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17GeneCards, 18GeneDecks
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Diseases related to Post-Transplant Lymphoproliferative Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin's lymphoma30.6LTA, TNFRSF1A, TNFRSF1B
2tonsillitis30.4IL1A, LTA
3hepatitis c30.3TNFRSF1B, TNF, IL10
4graft versus host disease30.2TNF, TNFRSF1A, IL1R1, IL10, LTA
5pneumonia30.2TNFRSF1B, TNF, IL10, IL6
6hematopoietic stem cell transplantation10.6
7hepatitis10.4
8cystic fibrosis10.2
9intussusception10.2
10autoimmune hepatitis10.2
11hepatitis b10.2
12aplastic anemia10.2
13hepatoblastoma10.2
14plasmacytoma10.2
15blastic plasmacytoid dendritic cell10.2
16peripheral t-cell lymphoma10.2
17infectious mononucleosis10.2
18cutaneous t cell lymphoma10.2
19neuritis10.2
20optic neuritis10.2
21lymphoblastic lymphoma10.2
22leprosy10.1SLC11A1
23adult-onset still's disease10.1TNFRSF1B
24schnitzler syndrome10.1IL1R1
25pulpitis10.1IL1A
26periodontitis10.1IL1A
27blau syndrome10.1TNF
28myocarditis10.1TNFRSF1B
29shigellosis10.1IL1R1, LTA
30familial cold autoinflammatory syndrome10.1TNFRSF1A, IL1R1
31chronic infantile neurological cutaneous articular syndrome10.1TNFRSF1A, IL1R1
32muckle-wells syndrome10.1IL1R1, TNFRSF1A
33crohn's disease10.1TNF, TNFRSF1B
34idiopathic myopathy10.1IL1R1, IL1A
35psoriatic arthritis10.1TNFRSF1B, TNF
36selective iga deficiency disease10.1IL10, LTA
37alopecia areata10.1IL1R1, IL1A
38lepromatous leprosy10.1IL10, LTA
39bacterial vaginosis10.1IL1R1, IL1A
40periodic fever, familial, autosomal dominant10.1TNFRSF1A, TNF
41abdominal aortic aneurysm10.1TNFRSF1A, TNFRSF1B
42paracoccidioidomycosis10.1TNFRSF1A, IL10
43adult respiratory distress syndrome10.1TNF, IL1R1
44visceral leishmaniasis10.1LTA, SLC11A1, IL10
45schizophrenia10.1TNFRSF1B, TNFRSF1A, LTA
46familial mediterranean fever10.1TNF, TNFRSF1A
47atopy10.0IL10, SLC11A1, LTA
48behcet's disease10.0TNFRSF1B, TNF, LTA
49lupus nephritis10.0LTA, IL10, TNFRSF1B
50ankylosing spondylitis10.0TNFRSF1B, TNF

Graphical network of the top 20 diseases related to Post-Transplant Lymphoproliferative Disease:



Diseases related to post-transplant lymphoproliferative disease

Symptoms for Post-Transplant Lymphoproliferative Disease

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Drugs & Therapeutics for Post-Transplant Lymphoproliferative Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Drug clinical trials:

Search ClinicalTrials for Post-Transplant Lymphoproliferative Disease

Search NIH Clinical Center for Post-Transplant Lymphoproliferative Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Post-Transplant Lymphoproliferative Disease:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Post-Transplant Lymphoproliferative Disease:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Post-Transplant Lymphoproliferative Disease

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Anatomical Context for Post-Transplant Lymphoproliferative Disease

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33MalaCards
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MalaCards organs/tissues related to Post-Transplant Lymphoproliferative Disease:

33
B cells, Liver, Lung, Bone, Heart, Kidney, T cells, Whole blood, Breast, Tonsil, Bone marrow, Tongue

Animal Models for Post-Transplant Lymphoproliferative Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Post-Transplant Lymphoproliferative Disease:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3TKT, IL6, IL1R1, TNFRSF1A, TNFRSF1B
2MP:00053758.0TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL6, TKT
3MP:00053887.5TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10, IL6
4MP:00053697.5TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10, IL6
5MP:00053917.3TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10, IL6
6MP:00053907.1TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
7MP:00107717.1B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
8MP:00053817.1B2M, TNFRSF1B, TNF, TNFRSF1A, IL10, IL6
9MP:00053867.1TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10, IL6
10MP:00053846.8B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
11MP:00053796.7B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
12MP:00036316.5B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
13MP:00053786.4B2M, TNF, TNFRSF1A, IL1R1, IL10, IL6
14MP:00053856.3B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
15MP:00053706.3B2M, TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1
16MP:00020066.2SLC11A1, B2M, TNFSF10, TNFRSF1B, TNF, TNFRSF1A
17MP:00107685.9B2M, TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1
18MP:00053765.9B2M, TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1
19MP:00053975.7TNFRSF1A, TNF, TNFRSF1B, TNFSF10, B2M, IL1R1
20MP:00053875.7TNFRSF1A, TNF, TNFRSF1B, TNFSF10, B2M, IL1R1

Publications for Post-Transplant Lymphoproliferative Disease

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52PubMed
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Articles related to Post-Transplant Lymphoproliferative Disease:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
Splenectomy prior to allogeneic hematopoietic SCT increases the risk of post-transplant lymphoproliferative disease. (24335998)
2013
2
Plasmacytoma-like post-transplantation lymphoproliferative disease occurring in a cardiac allograft: a case report and review of the literature. (22711849)
2012
3
Sustained response to intrathecal rituximab in EBV associated Post-transplant lymphoproliferative disease confined to the central nervous system following haematopoietic stem cell transplant. (21584931)
2012
4
Post-transplant lymphoproliferative disease (PTLD): Pharmacological, virological and other determinants. (21056103)
2011
5
Fludarabine, cyclophosphamide, doxorubicin (FCD), and rituximab: a remission induction therapy for aggressive pediatric post-transplant lymphoproliferative disease (PTLD). (21294246)
2011
6
CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia. (21559814)
2011
7
Epstein-Barr virus-associated pneumonia in patients with post-transplant lymphoproliferative disease after hematopoietic stem cell transplantation. (20345506)
2010
8
Post-transplant lymphoproliferative disease in pediatric lung transplant recipients: recent advances in monitoring. (19017289)
2009
9
Targeted monitoring of patients at high risk of post-transplant lymphoproliferative disease by quantitative Epstein-Barr virus polymerase chain reaction. (19497070)
2009
10
Late-onset post-transplant lymphoproliferative disease presenting as massive occult gastrointestinal haemorrhage. (18465033)
2008
11
Plasma Epstein-Barr viral load predicting response after chemotherapy for post-transplant lymphoproliferative disease. (18618224)
2008
12
Recombinant growth hormone use pretransplant and risk for post-transplant lymphoproliferative disease--a report of the NAPRTCS. (18179637)
2008
13
Ultrasound in abdominal and soft-tissue childhood PTLD (post-transplant lymphoproliferative disease). (17199182)
2007
14
Post-transplant lymphoproliferative disease in children following solid organ transplant and rituximab--the final answer? (17663676)
2007
15
Post-transplant lymphoproliferative disease in liver transplantation. (17392399)
2007
16
Case-control study of risk factors for the development of post-transplant lymphoproliferative disease in a pediatric heart transplant cohort. (17239124)
2007
17
Post-transplant lymphoproliferative disease and other Epstein-Barr virus diseases in allogeneic haematopoietic stem cell transplantation after introduction of monitoring of viral load by polymerase chain reaction. (17366054)
2007
18
Epstein-Barr virus-associated post-transplant lymphoproliferative disease with central nervous system involvement after unrelated allogeneic hematopoietic stem cell transplantation. (16321845)
2006
19
Post-transplant lymphoproliferative disease: association with induction therapy? (16597161)
2006
20
Slc11a1 (formerly Nramp1) polymorphisms and susceptibility to post-transplant lymphoproliferative disease following pediatric liver transplantation. (16734634)
2006
21
Late-onset post-transplant lymphoproliferative disease: a report of four patients in one center. (16840223)
2006
22
Cellular immunity to Epstein-Barr virus in liver transplant recipients treated with rituximab for post-transplant lymphoproliferative disease. (15707412)
2005
23
Early onset post-transplant lymphoproliferative disease is associated with allograft localization. (15877793)
2005
24
Sirolimus for pediatric liver transplant recipients with post-transplant lymphoproliferative disease and hepatoblastoma. (15176961)
2004
25
Epstein-Barr virus-specific cytotoxic T-lymphocytes for adoptive immunotherapy of post-transplant lymphoproliferative disease. (15183903)
2004
26
Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia. (12655423)
2003
27
Quantitative Epstein-Barr virus (EBV) serology in lung transplant recipients with primary EBV infection and/or post-transplant lymphoproliferative disease. (12683416)
2003
28
New insights into EBV-associated post-transplant lymphoproliferative disease. (12547538)
2003
29
Identification of early antigen BZLF1/ZEBRA protein of Epstein-Barr virus can predict the effectiveness of antiviral treatment in patients with post-transplant lymphoproliferative disease. (12199794)
2002
30
Immunotherapy for post-transplant lymphoproliferative disease. (12181039)
2002
31
Role of Epstein-Barr virus DNA load monitoring in prevention and early detection of post-transplant lymphoproliferative disease. (12153173)
2002
32
Low-dose chemotherapy for children with post-transplant lymphoproliferative disease. (11785850)
2002
33
Long-term survival after post-transplant lymphoproliferative disease in children. (12185479)
2002
34
The beta2-microglobulin/cystatin C ratio--a potential marker of post-transplant lymphoproliferative disease. (12508963)
2002
35
The Epstein-Barr virus and post-transplant lymphoproliferative disease: interplay of immunosuppression, EBV, and the immune system in disease pathogenesis. (11395971)
2001
36
Management of Epstein-Barr virus-induced post-transplant lymphoproliferative disease in recipients of solid organ transplantation. (12099356)
2001
37
Post-transplant lymphoproliferative disease in children. (11472603)
2001
38
Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of post-transplant lymphoproliferative disease in lung transplant patients. (11250352)
2001
39
Patients at risk for post-transplant lymphoproliferative disease can be identified in the first months after lung transplantation by quantitative-competitive-EBV-PCR. (11250349)
2001
40
Treatment of post-transplant lymphoproliferative disease with induction chemotherapy followed by haploidentical peripheral blood stem cell transplantation and Rituximab. (11277182)
2001
41
Predicting outcome from post-transplant lymphoproliferative disease: a risky business. (11472600)
2001
42
Management and outcome of liver recipients with post-transplant lymphoproliferative disease. (10690611)
2000
43
The pathology of liver-localized post-transplant lymphoproliferative disease: a report of three cases and a review of the literature. (10800993)
2000
44
Treatment of post-transplant lymphoproliferative disease with rituximab monoclonal antibody after lung transplantation. (10568575)
1999
45
Post-transplant lymphoproliferative disease may present with severe airway obstruction. (9667319)
1998
46
Increased beta 2-microglobulin (B2M) is useful in the detection of post-transplant lymphoproliferative disease (PTLD). (9067691)
1997
47
Retransplantation after post-transplant lymphoproliferative disease. (9203193)
1997
48
Treatment and prognosis of post-transplant lymphoproliferative disease. (9869878)
1997
49
EBV gene expression, EBNA antibody responses and EBV+ peripheral blood lymphocytes in post-transplant lymphoproliferative disease. (7858507)
1994
50
Factors associated with the development of post-transplant lymphoproliferative disease (PTLD) in Epstein-Barr virus (EBV)-seronegative adult liver transplant recipients. (11271213)
1994

Variations for Post-Transplant Lymphoproliferative Disease

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Expression for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Post-Transplant Lymphoproliferative Disease

Search GEO for disease gene expression data for Post-Transplant Lymphoproliferative Disease.

Pathways for genes affiliated with Post-Transplant Lymphoproliferative Disease

About this section
Sources:
50PathCards, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 54R&D Systems, 57SinoBiological
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Pathways related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TNFRSF1A, TNFRSF1B
2
Show member pathways
Amyotrophic lateral sclerosis (ALS)38
9.3TNFRSF1B, TNF, TNFRSF1A
39.3TNFRSF1B, TNF, TNFRSF1A
4
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.3TNFRSF1A, TNF, TNFRSF1B
5
Show member pathways
9.1TNFRSF1A, TNF, TNFSF10
6
Show member pathways
9.0LTA, TNFRSF1A, TNF, TNFRSF1B
7
Show member pathways
9.0LTA, TNFRSF1A, TNF, TNFRSF1B
89.0TNF, TNFRSF1A, IL1R1, LTA
98.9TNFSF10, TNFRSF10A, IL6
108.8TNF, TNFRSF1A, IL1R1, IL1A
11
Show member pathways
8.8IL10, TNFRSF1A, TNF, TNFRSF1B
128.7IL1A, IL6, TNF
138.6TNF, IL10, IL6
148.6TNF, IL10, IL6
15
Show member pathways
8.6TNFSF10, TNFRSF10A, TNF, TNFRSF1A, LTA
16
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
8.5TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A
178.4IL1A, IL6, IL1R1, TNF
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.4TNF, IL1R1, IL6, IL1A
19
Show member pathways
Immune response MIF in innate immunity response60
8.4IL1A, IL6, IL1R1, TNF
208.4IL1A, IL6, IL1R1, TNF
21
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.4IL10RA, IL6, IL10, TNF
22
Show member pathways
IL27-mediated signaling events38
8.3LTA, IL6, IL10, TNF
238.3TNF, IL1R1, IL10, IL6
24
Show member pathways
8.3TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL1A, LTA
25
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.2IL6, IL10, TNFRSF1A, TNF
26
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.2IL1A, IL6, IL10, TNF
278.2IL1A, IL6, IL10, TNF
288.2TNF, IL10, IL6, IL1A
298.2TNF, IL10, IL6, IL1A
30
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
8.2TNFRSF1B, TNF, TNFRSF1A, IL6, LTA
318.2TNFRSF1B, TNF, TNFRSF1A, IL6, LTA
328.2TNF, TNFRSF1A, IL1R1, IL6, LTA
338.0TNF, IL10, IL6, IL10RA, IL1A
34
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
7.9TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL1R1
357.9TNF, IL10, IL6, IL1A, LTA
36
Show member pathways
7.8TNFSF10, TNFRSF10A, TNF, TNFRSF1A, IL1R1, IL1A
37
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
7.8TNF, TNFRSF1A, IL1R1, IL6, IL1A, LTA
38
Show member pathways
7.6B2M, TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A
39
Show member pathways
7.6TNF, TNFRSF1A, IL10, IL6, IL10RA, IL1A
407.6TNF, TNFRSF1A, IL10, IL6, IL10RA, IL1A
41
Show member pathways
7.5TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL6, IL1A
42
Show member pathways
7.4TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL6
43
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
7.4TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL6
44
Show member pathways
7.3TNFSF10, TNFRSF10A, TNF, TNFRSF1A, IL6, IL1A
45
Show member pathways
6.4LTA, B2M, TNFRSF1B, TNF, TNFRSF1A, IL10
46
Show member pathways
6.0TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10, IL6
47
Show member pathways
6.0TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL1R1
48
Show member pathways
6.0TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL1R1
49
Show member pathways
6.0TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL1R1
50
Show member pathways
6.0IL1A, LTA, IL10RA, IL6, TNFSF10, TNFRSF10A

Compounds for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 3BitterDB, 24HMDB
See all sources

Compounds related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 202)
idCompoundScoreTop Affiliating Genes
1cuprophan459.0TNFRSF1A, TNFRSF1B, B2M, IL1R1
2rantes459.0IL1A, TNFRSF1A, TNFRSF1B, IL1R1, IL10
3tenidap45 299.8TNF, IL1R1, IL6, IL1A
412-o-tetradecanoylphorbol 13-acetate458.7IL1A, TNFRSF1A, TKT, IL1R1, TNFRSF1B, LTA
5fmlp458.6LTA, TNFRSF1A, TKT, IL1A, TNF, TNFRSF1B
6il-12458.5IL1R1, IL10, IL6, TNF
7leflunomide45 51 1110.4TNF, TNFRSF1A, IL1R1, IL6
8imiquimod45 61 29 1111.4IL10, IL6, TNF, IL1A
9lipoteichoic acid458.4TNF, LTA, IL6, IL10, IL1R1
10okt3458.3TNF, TNFRSF1A, IL10, IL6, LTA
11polymyxin b458.3IL6, IL10, IL1A, TNF
12adalimumab45 51 1110.3IL6, IL10, IL1R1, TNFRSF1A, TNF
13ionomycin458.2TNFSF10, LTA, IL1A, TNFRSF1A, TNF, IL10
14chloroquine45 3 51 29 1112.2TNFRSF1B, IL10, IL1R1, TNFRSF1A, B2M, TNF
15ccl345 299.2IL1R1, IL10, IL6, IL1A, TNF
16prednisolone45 29 1110.1LTA, IL6, IL10, TNF, IL1R1
17herbimycin a45 619.1TNF, IL6, IL1A, TKT, LTA, TNFRSF1A
18cisplatin45 51 61 1111.0B2M, TKT, TNFRSF1B, IL1R1, TNFRSF1A, TNFSF10
19pentoxifylline45 119.0LTA, IL1R1, IL10, IL1A, IL6, TNF
20h2o2458.0TNF, TNFSF10, LTA, IL1A, IL1R1, TNFRSF1A
21norepinephrine45 24 119.9TNFRSF1B, TNFRSF1A, TKT, IL1A, IL6, IL1R1
22curcumin457.9TNFRSF1A, TNFRSF1B, TNFSF10, TNF, IL1A, IL6
23groalpha457.9IL10, IL6, IL1A, TNF
24infliximab45 51 119.8TNF, TNFRSF1A, IL1R1, IL10, IL6, LTA
25etanercept45 51 119.8IL10, IL6, LTA, IL1R1, TNFRSF1A, TNFRSF1B
26hydrocortisone45 3 61 1110.8IL1A, IL6, IL10, IL1R1, TNF
27rituximab45 51 119.6B2M, TNF, IL1R1, IL10, IL6, TNFSF10
28il 10457.5TNFRSF1B, TNF, IL1R1, IL10, IL6, IL10RA
29sb 20358045 618.4TNFSF10, TNF, TNFRSF1A, IL1R1, IL10, IL6
30ivig457.4TNF, TNFRSF1A, IL1R1, IL10, IL1A, LTA
31endotoxin457.4TNFRSF1B, TNFRSF1A, IL1A, IL6, IL10, IL1R1
32cholesterol45 29 24 1110.4TNFRSF1B, LTA, IL6, IL1R1, B2M, TNFRSF1A
33vitamin d457.4IL1R1, B2M, TNFRSF1B, IL1A, LTA, SLC11A1
34calcitriol45 61 24 1110.3B2M, IL10, TNF, TNFRSF1A, IL6, IL1A
35methotrexate51 45 119.2IL6, TNFSF10, TNFRSF1B, TNF, TKT, IL1R1
36estrogen457.2TNFRSF1A, LTA, TNFSF10, TKT, IL6, IL1R1
37thymidine45 248.2IL10, IL6, IL1R1, TKT, B2M, TNF
38testosterone45 61 24 1110.2TNFRSF1B, IL1A, IL6, IL1R1, B2M, TNFSF10
39actinomycin d457.1LTA, IL1A, IL6, IL1R1, TNFRSF1A, TNFRSF1B
40indomethacin45 29 61 1110.1IL1A, B2M, TNFSF10, TNF, TNFRSF1A, IL1R1
41serine457.0B2M, TNFSF10, TNF, IL1R1, IL10RA, TNFRSF1A
42neopterin456.7LTA, IL1A, B2M, TNFRSF1B, TNF, TNFRSF1A
43dexamethasone45 51 29 119.6TNFSF10, TNFRSF10A, IL6, LTA, IL1A, IL10
44nitric oxide45 24 118.4SLC11A1, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL1R1
45pge2456.3TNF, TNFRSF1A, IL1R1, IL10, IL6, IL1A
46cyclosporin a45 29 618.3TNFRSF1B, LTA, IL1A, B2M, TNFSF10, TNF
47thalidomide45 51 61 119.3IL1A, IL6, TNFRSF1A, B2M, TNFSF10, TNFRSF10A
48retinoic acid45 247.2TNFRSF10A, TNFSF10, B2M, TNFRSF1B, TNF, TNFRSF1A
49vegf455.9IL6, IL1R1, TNFRSF1A, TNF, TNFRSF1B, TNFSF10
50cycloheximide455.7B2M, TNFSF10, TNFRSF10A, LTA, TNFRSF1B, TNF

GO Terms for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Sources:
16Gene Ontology
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Cellular components related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.2TNFRSF1A, TNF, TNFRSF1B
2integral component of plasma membraneGO:0058878.5TNFSF10, TNF, TNFRSF1A, IL1R1, SLC11A1
3external side of plasma membraneGO:0098978.2B2M, TNF, IL6
4plasma membraneGO:0058867.8SLC11A1, IL10RA, IL1R1, TNFRSF1A, TNF, TNFRSF1B
5extracellular regionGO:0055766.7B2M, TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1
6extracellular spaceGO:0056156.6LTA, B2M, TNFSF10, TNF, TNFRSF1A, IL10

Biological processes related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.1LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.0TNF, LTA
3positive regulation of membrane protein ectodomain proteolysisGO:0510449.9TNF, TNFRSF1B
4positive regulation of cytokine productionGO:0018199.9SLC11A1, TNF
5protein import into nucleus, translocationGO:0000609.8SLC11A1, TNF
6cellular response to estradiol stimulusGO:0713929.8TNFRSF1A, IL10
7positive regulation of interferon-gamma productionGO:0327299.8LTA, SLC11A1, TNF
8receptor biosynthetic processGO:0328009.8IL10, TNF
9negative regulation of cytokine secretion involved in immune responseGO:0027409.8IL10, TNF
10extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7TNFRSF10A, TNF, TNFRSF1A
11intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.7TNFRSF1A, TNF, TNFRSF1B
12response to molecule of bacterial originGO:0022379.7IL10, B2M
13defense response to protozoanGO:0428329.6IL6, SLC11A1
14defense response to bacteriumGO:0427429.6SLC11A1, IL10, TNFRSF1A
15negative regulation of growth of symbiont in hostGO:0441309.6LTA, IL10, TNF
16positive regulation of protein import into nucleus, translocationGO:0331609.6IL6, TNFRSF1A
17positive regulation of mitosisGO:0458409.5TNF, IL1A
18negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5IL1A, TNF
19defense response to Gram-negative bacteriumGO:0508299.5SLC11A1, IL6
20response to hypoxiaGO:0016669.5TNF, TNFRSF1A, LTA
21epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.5TNF, IL6
22negative regulation of interleukin-6 productionGO:0327159.5TNF, TNFRSF1A, IL10
23negative regulation of lipid storageGO:0108889.5TNF, IL6
24positive regulation of cytokine secretionGO:0507159.4TNF, IL10, IL1A
25apoptotic signaling pathwayGO:0971909.4TNFSF10, TNF, TNFRSF1A
26positive regulation of chemokine productionGO:0327229.4IL6, TNF
27response to amino acidGO:0432009.3IL6, TNFRSF1A
28positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.3TNFRSF1A, TNF, TNFSF10
29response to activityGO:0148239.3IL10, TNF
30immune responseGO:0069559.3IL1A, IL1R1, TNFRSF1B, TNFSF10
31defense response to Gram-positive bacteriumGO:0508309.3LTA, IL6, TNF
32humoral immune responseGO:0069599.2TNF, IL6, LTA
33response to insulinGO:0328689.1TNFSF10, IL10, IL6
34response to glucocorticoidGO:0513849.0IL6, IL10, TNF
35response to lipopolysaccharideGO:0324968.9TNFRSF1A, IL6, IL10RA, SLC11A1, LTA
36positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9TNF, IL10, IL6
37positive regulation of nitric oxide biosynthetic processGO:0454298.8IL6, TNF
38positive regulation of apoptotic processGO:0430658.8LTA, IL6, TNF, TNFSF10
39apoptotic processGO:0069158.6TNFSF10, TNFRSF10A, TNF, TNFRSF1A, IL1A, LTA
40cytokine-mediated signaling pathwayGO:0192218.4B2M, TNFRSF1A, IL6, IL10RA, IL1A
41response to drugGO:0424938.1LTA, IL6, IL10, TNF, B2M
42positive regulation of transcription from RNA polymerase II promoterGO:0459448.0SLC11A1, IL1A, IL6, IL10, TNFRSF1A, TNF
43inflammatory responseGO:0069547.7SLC11A1, IL1A, IL6, IL10, TNFRSF1A, TNF

Molecular functions related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:0050319.8TNFRSF1A, TNFRSF1B
2tumor necrosis factor receptor bindingGO:0051649.2TNFSF10, TNF, LTA
3protease bindingGO:0020209.2IL1R1, TNFRSF1A, TNF
4cytokine activityGO:0051257.5LTA, IL1A, IL6, IL10, TNF, TNFSF10
5protein bindingGO:0055155.8B2M, TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A

Products for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Sources for Post-Transplant Lymphoproliferative Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
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