MCID: PST046
MIFTS: 46

Post-Transplant Lymphoproliferative Disease malady

Rare diseases, Immune diseases categories

Summaries for Post-Transplant Lymphoproliferative Disease

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MalaCards based summary: Post-Transplant Lymphoproliferative Disease, also known as post-transplant lymphoproliferative disorder, is related to hodgkin lymphoma and tonsillitis. An important gene associated with Post-Transplant Lymphoproliferative Disease is IL10RA (interleukin 10 receptor, alpha), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway. The compounds cuprophan and rantes have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and lung, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Post-Transplant Lymphoproliferative Disease

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Post-Transplant Lymphoproliferative Disease, Aliases & Descriptions:

Name: Post-Transplant Lymphoproliferative Disease 30 41
 
Post-Transplant Lymphoproliferative Disorder 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Related Diseases for Post-Transplant Lymphoproliferative Disease

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Diseases related to Post-Transplant Lymphoproliferative Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin lymphoma30.9LTA, TNFRSF1A, TNFRSF1B
2tonsillitis30.8IL1A, LTA
3hepatitis c30.4TNFRSF1B, TNF, IL10
4pneumonia29.9TNFRSF1B, TNF, IL10, IL6
5leprosy10.6SLC11A1
6hematopoietic stem cell transplantation10.6
7adult-onset still's disease10.5TNFRSF1B
8schnitzler syndrome10.5IL1R1
9hepatitis10.5
10pulpitis10.5IL1A
11periodontitis10.4IL1A
12blau syndrome10.4TNF
13myocarditis10.4TNFRSF1B
14shigellosis10.4IL1R1, LTA
15familial cold autoinflammatory syndrome10.4TNFRSF1A, IL1R1
16cinca syndrome10.3TNFRSF1A, IL1R1
17muckle-wells syndrome10.3IL1R1, TNFRSF1A
18crohn's disease10.3TNF, TNFRSF1B
19idiopathic myopathy10.3IL1R1, IL1A
20psoriatic arthritis10.3TNFRSF1B, TNF
21alopecia areata10.3IL1R1, IL1A
22selective iga deficiency disease10.3IL10, LTA
23lepromatous leprosy10.3IL10, LTA
24bacterial vaginosis10.3IL1R1, IL1A
25abdominal aortic aneurysm10.3TNFRSF1A, TNFRSF1B
26periodic fever, familial10.3TNFRSF1A, TNF
27paracoccidioidomycosis10.3TNFRSF1A, IL10
28acute respiratory distress syndrome10.2TNF, IL1R1
29visceral leishmaniasis10.2LTA, SLC11A1, IL10
30schizophrenia10.2TNFRSF1B, TNFRSF1A, LTA
31cystic fibrosis10.2
32aplastic anemia10.2
33autoimmune hepatitis10.2
34hepatitis b10.2
35peripheral t-cell lymphoma10.2
36intussusception10.2
37hepatoblastoma10.2
38plasmacytoma10.2
39blastic plasmacytoid dendritic cell10.2
40familial mediterranean fever, ar10.2TNF, TNFRSF1A
41atopy10.2IL10, SLC11A1, LTA
42spondyloarthropathy 110.2TNFRSF1B, TNF
43toxic shock syndrome10.2TNF, LTA
44hcl-v10.2IL1A, TNFRSF1A
45interstitial lung disease10.2IL1R1, IL1A
46behcet's disease10.2TNFRSF1B, TNF, LTA
47lupus nephritis10.2LTA, IL10, TNFRSF1B
48alcoholic hepatitis10.2IL1A, TNF
49ameloblastoma10.2TNFSF10, TNFRSF10A, TNFRSF1A
50leishmaniasis10.2SLC11A1, IL10, TNFRSF1A

Graphical network of the top 20 diseases related to Post-Transplant Lymphoproliferative Disease:



Diseases related to post-transplant lymphoproliferative disease

Symptoms for Post-Transplant Lymphoproliferative Disease

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Drugs & Therapeutics for Post-Transplant Lymphoproliferative Disease

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Drug clinical trials:

Search ClinicalTrials for Post-Transplant Lymphoproliferative Disease

Search NIH Clinical Center for Post-Transplant Lymphoproliferative Disease

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Post-Transplant Lymphoproliferative Disease:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Post-Transplant Lymphoproliferative Disease:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Post-Transplant Lymphoproliferative Disease

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Anatomical Context for Post-Transplant Lymphoproliferative Disease

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MalaCards organs/tissues related to Post-Transplant Lymphoproliferative Disease:

31
Liver, Bone, Lung, Heart, T cells, Kidney, Whole blood, Breast, B cells, Bone marrow, Tonsil, Tongue

Animal Models for Post-Transplant Lymphoproliferative Disease or affiliated genes

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MGI Mouse Phenotypes related to Post-Transplant Lymphoproliferative Disease:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3TKT, IL6, IL1R1, TNFRSF1A, TNFRSF1B
2MP:00053758.0TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL6, TKT
3MP:00053887.5TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10, IL6
4MP:00053697.5TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10, IL6
5MP:00053917.3TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10, IL6
6MP:00053907.1TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
7MP:00107717.1B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
8MP:00053817.1B2M, TNFRSF1B, TNF, TNFRSF1A, IL10, IL6
9MP:00053867.1TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10, IL6
10MP:00053846.8B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
11MP:00053796.7B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
12MP:00036316.5B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
13MP:00053786.4B2M, TNF, TNFRSF1A, IL1R1, IL10, IL6
14MP:00053856.3B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
15MP:00053706.3B2M, TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1
16MP:00020066.2SLC11A1, B2M, TNFSF10, TNFRSF1B, TNF, TNFRSF1A
17MP:00107685.9B2M, TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1
18MP:00053765.9B2M, TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1
19MP:00053975.7TNFRSF1A, TNF, TNFRSF1B, TNFSF10, B2M, IL1R1
20MP:00053875.7TNFRSF1A, TNF, TNFRSF1B, TNFSF10, B2M, IL1R1

Publications for Post-Transplant Lymphoproliferative Disease

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Articles related to Post-Transplant Lymphoproliferative Disease:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
CD30 in pediatric post-transplant lymphoproliferative disease after solid organ transplant: characterization of a new therapeutic target. (25242095)
2014
2
Array CGH-based analysis of post-transplant plasmacytic hyperplasia reveals 'intact genomes' arguing against categorizing it as part of the post-transplant lymphoproliferative disease spectrum. (25041332)
2014
3
Splenectomy prior to allogeneic hematopoietic SCT increases the risk of post-transplant lymphoproliferative disease. (24335998)
2013
4
Plasmacytoma-like post-transplantation lymphoproliferative disease occurring in a cardiac allograft: a case report and review of the literature. (22711849)
2012
5
Sustained response to intrathecal rituximab in EBV associated Post-transplant lymphoproliferative disease confined to the central nervous system following haematopoietic stem cell transplant. (21584931)
2012
6
Post-transplant lymphoproliferative disease (PTLD): Pharmacological, virological and other determinants. (21056103)
2011
7
Fludarabine, cyclophosphamide, doxorubicin (FCD), and rituximab: a remission induction therapy for aggressive pediatric post-transplant lymphoproliferative disease (PTLD). (21294246)
2011
8
CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia. (21559814)
2011
9
Epstein-Barr virus-associated pneumonia in patients with post-transplant lymphoproliferative disease after hematopoietic stem cell transplantation. (20345506)
2010
10
Post-transplant lymphoproliferative disease in pediatric lung transplant recipients: recent advances in monitoring. (19017289)
2009
11
Targeted monitoring of patients at high risk of post-transplant lymphoproliferative disease by quantitative Epstein-Barr virus polymerase chain reaction. (19497070)
2009
12
Late-onset post-transplant lymphoproliferative disease presenting as massive occult gastrointestinal haemorrhage. (18465033)
2008
13
Plasma Epstein-Barr viral load predicting response after chemotherapy for post-transplant lymphoproliferative disease. (18618224)
2008
14
Recombinant growth hormone use pretransplant and risk for post-transplant lymphoproliferative disease--a report of the NAPRTCS. (18179637)
2008
15
Ultrasound in abdominal and soft-tissue childhood PTLD (post-transplant lymphoproliferative disease). (17199182)
2007
16
Post-transplant lymphoproliferative disease in children following solid organ transplant and rituximab--the final answer? (17663676)
2007
17
Post-transplant lymphoproliferative disease in liver transplantation. (17392399)
2007
18
Case-control study of risk factors for the development of post-transplant lymphoproliferative disease in a pediatric heart transplant cohort. (17239124)
2007
19
Epstein-Barr virus-associated post-transplant lymphoproliferative disease with central nervous system involvement after unrelated allogeneic hematopoietic stem cell transplantation. (16321845)
2006
20
Post-transplant lymphoproliferative disease: association with induction therapy? (16597161)
2006
21
Slc11a1 (formerly Nramp1) polymorphisms and susceptibility to post-transplant lymphoproliferative disease following pediatric liver transplantation. (16734634)
2006
22
Late-onset post-transplant lymphoproliferative disease: a report of four patients in one center. (16840223)
2006
23
Cellular immunity to Epstein-Barr virus in liver transplant recipients treated with rituximab for post-transplant lymphoproliferative disease. (15707412)
2005
24
Early onset post-transplant lymphoproliferative disease is associated with allograft localization. (15877793)
2005
25
Sirolimus for pediatric liver transplant recipients with post-transplant lymphoproliferative disease and hepatoblastoma. (15176961)
2004
26
Epstein-Barr virus-specific cytotoxic T-lymphocytes for adoptive immunotherapy of post-transplant lymphoproliferative disease. (15183903)
2004
27
Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia. (12655423)
2003
28
New insights into EBV-associated post-transplant lymphoproliferative disease. (12547538)
2003
29
Identification of early antigen BZLF1/ZEBRA protein of Epstein-Barr virus can predict the effectiveness of antiviral treatment in patients with post-transplant lymphoproliferative disease. (12199794)
2002
30
Immunotherapy for post-transplant lymphoproliferative disease. (12181039)
2002
31
Role of Epstein-Barr virus DNA load monitoring in prevention and early detection of post-transplant lymphoproliferative disease. (12153173)
2002
32
Low-dose chemotherapy for children with post-transplant lymphoproliferative disease. (11785850)
2002
33
Long-term survival after post-transplant lymphoproliferative disease in children. (12185479)
2002
34
The beta2-microglobulin/cystatin C ratio--a potential marker of post-transplant lymphoproliferative disease. (12508963)
2002
35
The Epstein-Barr virus and post-transplant lymphoproliferative disease: interplay of immunosuppression, EBV, and the immune system in disease pathogenesis. (11395971)
2001
36
Management of Epstein-Barr virus-induced post-transplant lymphoproliferative disease in recipients of solid organ transplantation. (12099356)
2001
37
Post-transplant lymphoproliferative disease in children. (11472603)
2001
38
Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of post-transplant lymphoproliferative disease in lung transplant patients. (11250352)
2001
39
Patients at risk for post-transplant lymphoproliferative disease can be identified in the first months after lung transplantation by quantitative-competitive-EBV-PCR. (11250349)
2001
40
Treatment of post-transplant lymphoproliferative disease with induction chemotherapy followed by haploidentical peripheral blood stem cell transplantation and Rituximab. (11277182)
2001
41
Predicting outcome from post-transplant lymphoproliferative disease: a risky business. (11472600)
2001
42
Management and outcome of liver recipients with post-transplant lymphoproliferative disease. (10690611)
2000
43
The pathology of liver-localized post-transplant lymphoproliferative disease: a report of three cases and a review of the literature. (10800993)
2000
44
Treatment of post-transplant lymphoproliferative disease with rituximab monoclonal antibody after lung transplantation. (10568575)
1999
45
Post-transplant lymphoproliferative disease may present with severe airway obstruction. (9667319)
1998
46
Increased beta 2-microglobulin (B2M) is useful in the detection of post-transplant lymphoproliferative disease (PTLD). (9067691)
1997
47
Retransplantation after post-transplant lymphoproliferative disease. (9203193)
1997
48
Treatment and prognosis of post-transplant lymphoproliferative disease. (9869878)
1997
49
EBV gene expression, EBNA antibody responses and EBV+ peripheral blood lymphocytes in post-transplant lymphoproliferative disease. (7858507)
1994
50
Factors associated with the development of post-transplant lymphoproliferative disease (PTLD) in Epstein-Barr virus (EBV)-seronegative adult liver transplant recipients. (11271213)
1994

Variations for Post-Transplant Lymphoproliferative Disease

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Expression for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Search GEO for disease gene expression data for Post-Transplant Lymphoproliferative Disease.

Pathways for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Pathways related to Post-Transplant Lymphoproliferative Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TNFRSF1A, TNFRSF1B
2
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
9.3TNF, TNFRSF1A, TNFRSF1B
39.3TNFRSF1A, TNF, TNFRSF1B
4
Show member pathways
Amyotrophic lateral sclerosis (ALS)36
9.3TNFRSF1A, TNF, TNFRSF1B
5
Show member pathways
9.1TNF, TNFSF10, TNFRSF1A
6
Show member pathways
9.0TNFRSF1B, TNF, TNFRSF1A, LTA
7
Show member pathways
9.0TNFRSF1B, TNFRSF1A, TNF, LTA
89.0TNFRSF1A, TNF, LTA, IL1R1
98.9TNFSF10, TNFRSF10A, IL6
108.8IL1R1, IL1A, TNFRSF1A, TNF
11
Show member pathways
8.8TNFRSF1A, IL10, TNFRSF1B, TNF
128.7IL1A, IL6, TNF
138.6IL6, IL10, TNF
148.6IL10, TNF, IL6
15
Show member pathways
8.6TNFRSF10A, TNFSF10, TNF, TNFRSF1A, LTA
16
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
8.5TNFRSF1A, TNF, TNFRSF1B, TNFRSF10A, TNFSF10
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.4TNF, IL1R1, IL6, IL1A
188.4IL1R1, IL6, IL1A, TNF
19
Show member pathways
Immune response MIF in innate immunity response58
8.4TNF, IL1A, IL6, IL1R1
208.4IL1R1, IL1A, IL6, TNF
21
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.4TNF, IL10, IL6, IL10RA
22
Show member pathways
IL27-mediated signaling events36
8.3TNF, IL10, LTA, IL6
238.3IL1R1, IL10, TNF, IL6
24
Show member pathways
8.3IL1A, IL1R1, LTA, TNFRSF1A, TNF, TNFRSF1B
25
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.2IL6, IL10, TNF, TNFRSF1A
268.2TNF, IL1A, IL6, IL10
278.2TNF, IL10, IL1A, IL6
288.2IL6, IL10, IL1A, TNF
29
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.2IL10, TNF, IL6, IL1A
308.2LTA, TNFRSF1A, IL6, TNFRSF1B, TNF
31
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
8.2LTA, TNFRSF1B, TNFRSF1A, IL6, TNF
328.2LTA, IL6, IL1R1, TNFRSF1A, TNF
338.0IL10, IL10RA, IL6, IL1A, TNF
34
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
7.9TNFRSF1A, IL1R1, LTA, TNF, TNFSF10, TNFRSF1B
357.9LTA, IL1A, IL6, IL10, TNF
36
Show member pathways
7.8TNFRSF1A, LTA, IL1A, TNFRSF10A, IL1R1, TNFSF10
37
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
7.8TNF, TNFRSF1A, LTA, IL1A, IL6, IL1R1
38
Show member pathways
7.6TNFRSF1A, B2M, TNFRSF10A, TNFRSF1B, TNF, LTA
39
Show member pathways
7.6IL6, IL10RA, IL1A, TNF, IL10, TNFRSF1A
407.6IL10, IL1A, TNFRSF1A, IL6, IL10RA, TNF
41
Show member pathways
7.5TNFRSF1A, IL1R1, IL6, TNF, IL1A, TNFRSF1B
42
Show member pathways
7.4TNF, TNFRSF1B, IL6, TNFRSF1A, TNFRSF10A, TNFSF10
43
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
7.4IL6, LTA, TNFRSF1A, TNFRSF10A, TNF, TNFRSF1B
44
Show member pathways
7.3TNFSF10, TNF, TNFRSF1A, IL6, IL1A, LTA
45
Show member pathways
6.4B2M, TNFRSF1B, TNF, TNFRSF1A, IL10, IL6
46
Show member pathways
6.0IL6, IL10, IL1R1, TNFRSF1A, TNF, TNFRSF1B
47
Show member pathways
6.0TNFSF10, TNFRSF10A, TNF, TNFRSF1A, IL1R1, IL10
48
Show member pathways
6.0IL1R1, TNFRSF1A, TNFSF10, TNFRSF10A, TNFRSF1B, TNF
49
Show member pathways
6.0IL6, IL10, LTA, IL1A, IL10RA, TNFRSF10A
50
Show member pathways
6.0TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10

Compounds for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Compounds related to Post-Transplant Lymphoproliferative Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 202)
idCompoundScoreTop Affiliating Genes
1cuprophan439.0TNFRSF1A, TNFRSF1B, B2M, IL1R1
2rantes439.0IL1A, TNFRSF1A, TNFRSF1B, IL1R1, IL10
3tenidap43 289.8TNF, IL1R1, IL6, IL1A
412-o-tetradecanoylphorbol 13-acetate438.7IL1A, TNFRSF1A, TKT, IL1R1, TNFRSF1B, LTA
5fmlp438.6LTA, TNFRSF1A, TKT, IL1A, TNF, TNFRSF1B
6il-12438.5IL1R1, IL10, IL6, TNF
7leflunomide43 49 1210.4TNF, TNFRSF1A, IL1R1, IL6
8imiquimod43 59 28 1211.4IL10, IL6, TNF, IL1A
9lipoteichoic acid438.4TNF, LTA, IL6, IL10, IL1R1
10okt3438.3TNF, TNFRSF1A, IL10, IL6, LTA
11polymyxin b438.3IL6, IL10, IL1A, TNF
12adalimumab43 49 1210.3IL6, IL10, IL1R1, TNFRSF1A, TNF
13ionomycin438.2TNFSF10, LTA, IL1A, TNFRSF1A, TNF, IL10
14chloroquine43 2 49 28 1212.2TNFRSF1B, IL10, IL1R1, TNFRSF1A, B2M, TNF
15ccl343 289.2IL1R1, IL10, IL6, IL1A, TNF
16prednisolone43 28 1210.1LTA, IL6, IL10, TNF, IL1R1
17herbimycin a43 599.1TNF, IL6, IL1A, TKT, LTA, TNFRSF1A
18cisplatin43 49 59 1211.0B2M, TKT, TNFRSF1B, IL1R1, TNFRSF1A, TNFSF10
19pentoxifylline43 129.0LTA, IL1R1, IL10, IL1A, IL6, TNF
20h2o2438.0TNF, TNFSF10, LTA, IL1A, IL1R1, TNFRSF1A
21norepinephrine43 24 129.9TNFRSF1B, TNFRSF1A, TKT, IL1A, IL6, IL1R1
22curcumin437.9TNFRSF1A, TNFRSF1B, TNFSF10, TNF, IL1A, IL6
23groalpha437.9IL10, IL6, IL1A, TNF
24infliximab43 49 129.8TNF, TNFRSF1A, IL1R1, IL10, IL6, LTA
25etanercept43 49 129.8IL10, IL6, LTA, IL1R1, TNFRSF1A, TNFRSF1B
26hydrocortisone43 2 59 1210.8IL1A, IL6, IL10, IL1R1, TNF
27rituximab43 49 129.6B2M, TNF, IL1R1, IL10, IL6, TNFSF10
28il 10437.5TNFRSF1B, TNF, IL1R1, IL10, IL6, IL10RA
29sb 20358043 598.4TNFSF10, TNF, TNFRSF1A, IL1R1, IL10, IL6
30ivig437.4TNF, TNFRSF1A, IL1R1, IL10, IL1A, LTA
31endotoxin437.4TNFRSF1B, TNFRSF1A, IL1A, IL6, IL10, IL1R1
32cholesterol43 28 24 1210.4TNFRSF1B, LTA, IL6, IL1R1, B2M, TNFRSF1A
33vitamin d437.4IL1R1, B2M, TNFRSF1B, IL1A, LTA, SLC11A1
34calcitriol43 59 24 1210.3B2M, IL10, TNF, TNFRSF1A, IL6, IL1A
35methotrexate49 43 129.2IL6, TNFSF10, TNFRSF1B, TNF, TKT, IL1R1
36estrogen437.2TNFRSF1A, LTA, TNFSF10, TKT, IL6, IL1R1
37thymidine43 248.2IL10, IL6, IL1R1, TKT, B2M, TNF
38testosterone43 59 24 1210.2TNFRSF1B, IL1A, IL6, IL1R1, B2M, TNFSF10
39actinomycin d437.1LTA, IL1A, IL6, IL1R1, TNFRSF1A, TNFRSF1B
40indomethacin43 28 59 1210.1IL1A, B2M, TNFSF10, TNF, TNFRSF1A, IL1R1
41serine437.0B2M, TNFSF10, TNF, IL1R1, IL10RA, TNFRSF1A
42neopterin436.7LTA, IL1A, B2M, TNFRSF1B, TNF, TNFRSF1A
43dexamethasone43 49 28 129.6TNFSF10, TNFRSF10A, IL6, LTA, IL1A, IL10
44nitric oxide43 24 128.4SLC11A1, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL1R1
45pge2436.3TNF, TNFRSF1A, IL1R1, IL10, IL6, IL1A
46cyclosporin a43 28 598.3TNFRSF1B, LTA, IL1A, B2M, TNFSF10, TNF
47thalidomide43 49 59 129.3IL1A, IL6, TNFRSF1A, B2M, TNFSF10, TNFRSF10A
48retinoic acid43 247.2TNFRSF10A, TNFSF10, B2M, TNFRSF1B, TNF, TNFRSF1A
49vegf435.9IL6, IL1R1, TNFRSF1A, TNF, TNFRSF1B, TNFSF10
50cycloheximide435.7B2M, TNFSF10, TNFRSF10A, LTA, TNFRSF1B, TNF

GO Terms for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Cellular components related to Post-Transplant Lymphoproliferative Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:00451219.2TNFRSF1A, TNF, TNFRSF1B
2integral component of plasma membraneGO:00058878.5IL1R1, TNFRSF1A, TNF, TNFSF10, SLC11A1
3external side of plasma membraneGO:00098978.2IL6, B2M, TNF
4plasma membraneGO:00058867.8SLC11A1, B2M, IL1R1, TNFRSF1A, TNF, TNFRSF1B
5extracellular regionGO:00055766.7IL1A, B2M, IL6, IL1R1, TNFRSF1A, TNF
6extracellular spaceGO:00056156.6IL10, B2M, TNFSF10, TNF, TNFRSF1A, IL6

Biological processes related to Post-Transplant Lymphoproliferative Disease according to GeneCards Suite gene sharing:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:000287610.1LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.0TNF, LTA
3positive regulation of membrane protein ectodomain proteolysisGO:00510449.9TNFRSF1B, TNF
4positive regulation of cytokine productionGO:00018199.9TNF, SLC11A1
5protein import into nucleus, translocationGO:00000609.8TNF, SLC11A1
6cellular response to estradiol stimulusGO:00713929.8IL10, TNFRSF1A
7positive regulation of interferon-gamma productionGO:00327299.8SLC11A1, LTA, TNF
8receptor biosynthetic processGO:00328009.8TNF, IL10
9negative regulation of cytokine secretion involved in immune responseGO:00027409.8IL10, TNF
10extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.7TNFRSF1A, TNF, TNFRSF10A
11intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.7TNFRSF1A, TNF, TNFRSF1B
12response to molecule of bacterial originGO:00022379.7B2M, IL10
13defense response to protozoanGO:00428329.6IL6, SLC11A1
14defense response to bacteriumGO:00427429.6IL10, TNFRSF1A, SLC11A1
15negative regulation of growth of symbiont in hostGO:00441309.6LTA, IL10, TNF
16positive regulation of protein import into nucleus, translocationGO:00331609.6IL6, TNFRSF1A
17positive regulation of mitosisGO:00458409.5IL1A, TNF
18negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.5IL1A, TNF
19defense response to Gram-negative bacteriumGO:00508299.5SLC11A1, IL6
20response to hypoxiaGO:00016669.5TNF, LTA, TNFRSF1A
21negative regulation of lipid storageGO:00108889.5IL6, TNF
22negative regulation of interleukin-6 productionGO:00327159.5TNF, TNFRSF1A, IL10
23epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.5TNF, IL6
24positive regulation of cytokine secretionGO:00507159.4IL1A, TNF, IL10
25apoptotic signaling pathwayGO:00971909.4TNFRSF1A, TNF, TNFSF10
26positive regulation of chemokine productionGO:00327229.4IL6, TNF
27response to amino acidGO:00432009.3TNFRSF1A, IL6
28positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.3TNF, TNFRSF1A, TNFSF10
29response to activityGO:00148239.3TNF, IL10
30immune responseGO:00069559.3IL1A, TNFRSF1B, IL1R1, TNFSF10
31defense response to Gram-positive bacteriumGO:00508309.3TNF, IL6, LTA
32humoral immune responseGO:00069599.2LTA, TNF, IL6
33response to insulinGO:00328689.1TNFSF10, IL10, IL6
34response to glucocorticoidGO:00513849.0TNF, IL10, IL6
35response to lipopolysaccharideGO:00324968.9IL6, TNFRSF1A, IL10RA, SLC11A1, LTA
36positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.9IL6, TNF, IL10
37positive regulation of nitric oxide biosynthetic processGO:00454298.8IL6, TNF
38positive regulation of apoptotic processGO:00430658.8IL6, LTA, TNF, TNFSF10
39apoptotic processGO:00069158.6LTA, TNFRSF10A, TNF, TNFRSF1A, IL1A, TNFSF10
40cytokine-mediated signaling pathwayGO:00192218.4IL6, B2M, TNFRSF1A, IL1A, IL10RA
41response to drugGO:00424938.1TNF, IL10, IL6, LTA, B2M
42positive regulation of transcription from RNA polymerase II promoterGO:00459448.0IL10, TNFRSF1A, SLC11A1, IL6, IL1A, TNF
43inflammatory responseGO:00069547.7SLC11A1, IL1A, IL6, IL10, TNFRSF1B, TNFRSF1A

Molecular functions related to Post-Transplant Lymphoproliferative Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:00050319.8TNFRSF1A, TNFRSF1B
2tumor necrosis factor receptor bindingGO:00051649.2LTA, TNFSF10, TNF
3protease bindingGO:00020209.2IL1R1, TNF, TNFRSF1A
4cytokine activityGO:00051257.5TNF, IL10, IL6, IL1A, LTA, TNFSF10
5protein bindingGO:00055155.8B2M, TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A

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3CDC
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