PTLD
MCID: PST046
MIFTS: 60

Post-Transplant Lymphoproliferative Disease (PTLD) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Post-Transplant Lymphoproliferative Disease

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Wikipedia:65 Post-transplant lymphoproliferative disorder (PTLD) is the name given to a B-cell proliferation due to... more...

MalaCards based summary: Post-Transplant Lymphoproliferative Disease, also known as post-transplant lymphoproliferative disorder, is related to hodgkin's lymphoma and tonsillitis. An important gene associated with Post-Transplant Lymphoproliferative Disease is IL10RA (interleukin 10 receptor, alpha), and among its related pathways are 14-3-3 and Regulation of BAD Activity and Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway. The compounds cuprophan and rantes have been mentioned in the context of this disorder. Affiliated tissues include b cells, liver and lung, and related mouse phenotypes are renal/urinary system and adipose tissue.

Aliases & Classifications for Post-Transplant Lymphoproliferative Disease

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Sources:
30LifeMap Discovery®, 42NIH Rare Diseases, 48Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Post-Transplant Lymphoproliferative Disease, Aliases & Descriptions:

Name: Post-Transplant Lymphoproliferative Disease 30 42
Post-Transplant Lymphoproliferative Disorder 62
Post Transplant Lymphoproliferative Disease 62
 
Posttransplant Lymphoproliferative Disease 48
Ptld 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
posttransplant lymphoproliferative disease:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable


External Ids:

ICD10 via Orphanet26 D47.9
UMLS via Orphanet63 C0432487

Related Diseases for Post-Transplant Lymphoproliferative Disease

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Diseases related to Post-Transplant Lymphoproliferative Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1hodgkin's lymphoma30.9LTA, TNFRSF1A, TNFRSF1B
2tonsillitis30.8LTA, IL1A
3hepatitis c30.4TNFRSF1B, IL10, TNF
4graft versus host disease30.1LTA, TNF, TNFRSF1A, IL1R1, IL10
5pneumonia29.9TNFRSF1B, TNF, IL10, IL6
6leprosy10.6SLC11A1
7hematopoietic stem cell transplantation10.6
8adult-onset still's disease10.5TNFRSF1B
9schnitzler syndrome10.5IL1R1
10pulpitis10.5IL1A
11hepatitis10.5
12periodontitis10.4IL1A
13blau syndrome10.4TNF
14myocarditis10.4TNFRSF1B
15shigellosis10.4LTA, IL1R1
16familial cold autoinflammatory syndrome10.4TNFRSF1A, IL1R1
17chronic infantile neurological cutaneous articular syndrome10.4TNFRSF1A, IL1R1
18muckle-wells syndrome10.3TNFRSF1A, IL1R1
19crohn's disease10.3TNFRSF1B, TNF
20idiopathic myopathy10.3IL1R1, IL1A
21psoriatic arthritis10.3TNFRSF1B, TNF
22selective iga deficiency disease10.3LTA, IL10
23alopecia areata10.3IL1R1, IL1A
24lepromatous leprosy10.3IL10, LTA
25bacterial vaginosis10.3IL1R1, IL1A
26abdominal aortic aneurysm10.3TNFRSF1A, TNFRSF1B
27periodic fever, familial, autosomal dominant10.3TNF, TNFRSF1A
28paracoccidioidomycosis10.3IL10, TNFRSF1A
29adult respiratory distress syndrome10.2IL1R1, TNF
30visceral leishmaniasis10.2IL10, SLC11A1, LTA
31schizophrenia10.2TNFRSF1A, LTA, TNFRSF1B
32familial mediterranean fever10.2TNF, TNFRSF1A
33toxic shock syndrome10.2LTA, TNF
34aplastic anemia10.2
35autoimmune hepatitis10.2
36cystic fibrosis10.2
37hepatitis b10.2
38peripheral t-cell lymphoma10.2
39intussusception10.2
40hepatoblastoma10.2
41plasmacytoma10.2
42blastic plasmacytoid dendritic cell10.2
43atopy10.2IL10, LTA, SLC11A1
44behcet's disease10.2TNF, LTA, TNFRSF1B
45lupus nephritis10.2TNFRSF1B, LTA, IL10
46lymphoblastic lymphoma10.2
47infectious mononucleosis10.2
48cutaneous t cell lymphoma10.2
49neuritis10.2
50optic neuritis10.2

Graphical network of the top 20 diseases related to Post-Transplant Lymphoproliferative Disease:



Diseases related to post-transplant lymphoproliferative disease

Symptoms for Post-Transplant Lymphoproliferative Disease

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Drugs & Therapeutics for Post-Transplant Lymphoproliferative Disease

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Drug clinical trials:

Search ClinicalTrials for Post-Transplant Lymphoproliferative Disease

Search NIH Clinical Center for Post-Transplant Lymphoproliferative Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Post-Transplant Lymphoproliferative Disease:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Post-Transplant Lymphoproliferative Disease:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Post-Transplant Lymphoproliferative Disease

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Anatomical Context for Post-Transplant Lymphoproliferative Disease

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MalaCards organs/tissues related to Post-Transplant Lymphoproliferative Disease:

32
B cells, Liver, Lung, Bone, Heart, Kidney, T cells, Whole blood, Breast, Bone marrow, Tonsil, Tongue

Animal Models for Post-Transplant Lymphoproliferative Disease or affiliated genes

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MGI Mouse Phenotypes related to Post-Transplant Lymphoproliferative Disease:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3IL1R1, IL6, TNFRSF1A, TNFRSF1B, TKT
2MP:00053758.0TNFRSF1B, TNFRSF1A, IL1R1, TNF, IL6, TKT
3MP:00053887.5TNF, TNFRSF1A, IL10, LTA, IL6, IL1R1
4MP:00053697.5TNF, IL6, TNFRSF1B, IL1R1, IL10, TNFRSF1A
5MP:00053917.3LTA, TNFRSF1A, TKT, TNFRSF1B, IL1R1, IL10
6MP:00053907.1TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
7MP:00107717.1TNFRSF1B, B2M, TNFRSF1A, IL1R1, IL10, IL6
8MP:00053817.1IL10, TNFRSF1A, TNF, TNFRSF1B, B2M, IL10RA
9MP:00053867.1TKT, TNFRSF1A, IL6, TNFRSF1B, IL10, IL1R1
10MP:00053846.8IL6, B2M, TNFRSF1B, TNF, TNFRSF1A, IL10RA
11MP:00053796.7LTA, TKT, IL6, IL10, IL1R1, TNFRSF1A
12MP:00036316.5TNFRSF1B, IL6, B2M, LTA, TKT, IL10
13MP:00053786.4IL10, TNFRSF1A, B2M, TNF, TKT, LTA
14MP:00053856.3B2M, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10
15MP:00053706.3LTA, B2M, IL10, TNFRSF1B, IL6, TKT
16MP:00020066.2B2M, TNFRSF1B, TNF, IL1R1, TNFRSF1A, IL10
17MP:00107685.9LTA, SLC11A1, TKT, IL6, IL1R1, TNF
18MP:00053765.9B2M, TNFSF10, TNFRSF1B, TNF, TNFRSF1A, IL1R1
19MP:00053975.7TNFRSF1A, TNF, TNFRSF1B, B2M, IL6, IL1R1
20MP:00053875.7SLC11A1, IL1A, IL10RA, IL6, LTA, IL10

Publications for Post-Transplant Lymphoproliferative Disease

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Articles related to Post-Transplant Lymphoproliferative Disease:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
CD30 in pediatric post-transplant lymphoproliferative disease after solid organ transplant: characterization of a new therapeutic target. (25242095)
2014
2
Array CGH-based analysis of post-transplant plasmacytic hyperplasia reveals 'intact genomes' arguing against categorizing it as part of the post-transplant lymphoproliferative disease spectrum. (25041332)
2014
3
Splenectomy prior to allogeneic hematopoietic SCT increases the risk of post-transplant lymphoproliferative disease. (24335998)
2013
4
Plasmacytoma-like post-transplantation lymphoproliferative disease occurring in a cardiac allograft: a case report and review of the literature. (22711849)
2012
5
Sustained response to intrathecal rituximab in EBV associated Post-transplant lymphoproliferative disease confined to the central nervous system following haematopoietic stem cell transplant. (21584931)
2012
6
Post-transplant lymphoproliferative disease (PTLD): Pharmacological, virological and other determinants. (21056103)
2011
7
Fludarabine, cyclophosphamide, doxorubicin (FCD), and rituximab: a remission induction therapy for aggressive pediatric post-transplant lymphoproliferative disease (PTLD). (21294246)
2011
8
CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia. (21559814)
2011
9
Epstein-Barr virus-associated pneumonia in patients with post-transplant lymphoproliferative disease after hematopoietic stem cell transplantation. (20345506)
2010
10
Post-transplant lymphoproliferative disease in pediatric lung transplant recipients: recent advances in monitoring. (19017289)
2009
11
Targeted monitoring of patients at high risk of post-transplant lymphoproliferative disease by quantitative Epstein-Barr virus polymerase chain reaction. (19497070)
2009
12
Late-onset post-transplant lymphoproliferative disease presenting as massive occult gastrointestinal haemorrhage. (18465033)
2008
13
Plasma Epstein-Barr viral load predicting response after chemotherapy for post-transplant lymphoproliferative disease. (18618224)
2008
14
Recombinant growth hormone use pretransplant and risk for post-transplant lymphoproliferative disease--a report of the NAPRTCS. (18179637)
2008
15
Ultrasound in abdominal and soft-tissue childhood PTLD (post-transplant lymphoproliferative disease). (17199182)
2007
16
Post-transplant lymphoproliferative disease in children following solid organ transplant and rituximab--the final answer? (17663676)
2007
17
Post-transplant lymphoproliferative disease in liver transplantation. (17392399)
2007
18
Case-control study of risk factors for the development of post-transplant lymphoproliferative disease in a pediatric heart transplant cohort. (17239124)
2007
19
Epstein-Barr virus-associated post-transplant lymphoproliferative disease with central nervous system involvement after unrelated allogeneic hematopoietic stem cell transplantation. (16321845)
2006
20
Post-transplant lymphoproliferative disease: association with induction therapy? (16597161)
2006
21
Slc11a1 (formerly Nramp1) polymorphisms and susceptibility to post-transplant lymphoproliferative disease following pediatric liver transplantation. (16734634)
2006
22
Late-onset post-transplant lymphoproliferative disease: a report of four patients in one center. (16840223)
2006
23
Cellular immunity to Epstein-Barr virus in liver transplant recipients treated with rituximab for post-transplant lymphoproliferative disease. (15707412)
2005
24
Early onset post-transplant lymphoproliferative disease is associated with allograft localization. (15877793)
2005
25
Sirolimus for pediatric liver transplant recipients with post-transplant lymphoproliferative disease and hepatoblastoma. (15176961)
2004
26
Epstein-Barr virus-specific cytotoxic T-lymphocytes for adoptive immunotherapy of post-transplant lymphoproliferative disease. (15183903)
2004
27
Pulmonary re-occurrence of post-transplant lymphoproliferative disease with hypogammaglobulinaemia. (12655423)
2003
28
Quantitative Epstein-Barr virus (EBV) serology in lung transplant recipients with primary EBV infection and/or post-transplant lymphoproliferative disease. (12683416)
2003
29
New insights into EBV-associated post-transplant lymphoproliferative disease. (12547538)
2003
30
Identification of early antigen BZLF1/ZEBRA protein of Epstein-Barr virus can predict the effectiveness of antiviral treatment in patients with post-transplant lymphoproliferative disease. (12199794)
2002
31
Immunotherapy for post-transplant lymphoproliferative disease. (12181039)
2002
32
Role of Epstein-Barr virus DNA load monitoring in prevention and early detection of post-transplant lymphoproliferative disease. (12153173)
2002
33
Low-dose chemotherapy for children with post-transplant lymphoproliferative disease. (11785850)
2002
34
Long-term survival after post-transplant lymphoproliferative disease in children. (12185479)
2002
35
The beta2-microglobulin/cystatin C ratio--a potential marker of post-transplant lymphoproliferative disease. (12508963)
2002
36
The Epstein-Barr virus and post-transplant lymphoproliferative disease: interplay of immunosuppression, EBV, and the immune system in disease pathogenesis. (11395971)
2001
37
Management of Epstein-Barr virus-induced post-transplant lymphoproliferative disease in recipients of solid organ transplantation. (12099356)
2001
38
Post-transplant lymphoproliferative disease in children. (11472603)
2001
39
Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of post-transplant lymphoproliferative disease in lung transplant patients. (11250352)
2001
40
Patients at risk for post-transplant lymphoproliferative disease can be identified in the first months after lung transplantation by quantitative-competitive-EBV-PCR. (11250349)
2001
41
Treatment of post-transplant lymphoproliferative disease with induction chemotherapy followed by haploidentical peripheral blood stem cell transplantation and Rituximab. (11277182)
2001
42
Predicting outcome from post-transplant lymphoproliferative disease: a risky business. (11472600)
2001
43
Management and outcome of liver recipients with post-transplant lymphoproliferative disease. (10690611)
2000
44
The pathology of liver-localized post-transplant lymphoproliferative disease: a report of three cases and a review of the literature. (10800993)
2000
45
Post-transplant lymphoproliferative disease may present with severe airway obstruction. (9667319)
1998
46
Increased beta 2-microglobulin (B2M) is useful in the detection of post-transplant lymphoproliferative disease (PTLD). (9067691)
1997
47
Retransplantation after post-transplant lymphoproliferative disease. (9203193)
1997
48
Treatment and prognosis of post-transplant lymphoproliferative disease. (9869878)
1997
49
EBV gene expression, EBNA antibody responses and EBV+ peripheral blood lymphocytes in post-transplant lymphoproliferative disease. (7858507)
1994
50
Factors associated with the development of post-transplant lymphoproliferative disease (PTLD) in Epstein-Barr virus (EBV)-seronegative adult liver transplant recipients. (11271213)
1994

Variations for Post-Transplant Lymphoproliferative Disease

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Expression for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Expression patterns in normal tissues for genes affiliated with Post-Transplant Lymphoproliferative Disease

Search GEO for disease gene expression data for Post-Transplant Lymphoproliferative Disease.

Pathways for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Pathways related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8TNFRSF1A, TNFRSF1B
2
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.3TNF, TNFRSF1A, TNFRSF1B
39.3TNFRSF1A, TNF, TNFRSF1B
4
Show member pathways
Amyotrophic lateral sclerosis (ALS)37
9.3TNFRSF1A, TNF, TNFRSF1B
5
Show member pathways
9.1TNF, TNFSF10, TNFRSF1A
6
Show member pathways
9.0TNFRSF1B, TNF, TNFRSF1A, LTA
7
Show member pathways
9.0TNFRSF1B, TNFRSF1A, TNF, LTA
89.0TNFRSF1A, TNF, LTA, IL1R1
98.9TNFSF10, TNFRSF10A, IL6
108.8IL1R1, IL1A, TNFRSF1A, TNF
11
Show member pathways
8.8TNFRSF1A, IL10, TNFRSF1B, TNF
128.7IL1A, IL6, TNF
138.6IL6, IL10, TNF
148.6IL10, TNF, IL6
15
Show member pathways
8.6TNFRSF10A, TNFSF10, TNF, TNFRSF1A, LTA
16
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
8.5TNFRSF1A, TNF, TNFRSF1B, TNFRSF10A, TNFSF10
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.4TNF, IL1R1, IL6, IL1A
188.4IL1R1, IL6, IL1A, TNF
19
Show member pathways
Immune response MIF in innate immunity response60
8.4TNF, IL1A, IL6, IL1R1
208.4IL1R1, IL1A, IL6, TNF
21
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.4TNF, IL10, IL6, IL10RA
22
Show member pathways
IL27-mediated signaling events37
8.3TNF, IL10, LTA, IL6
238.3IL1R1, IL10, TNF, IL6
24
Show member pathways
8.3IL1A, IL1R1, LTA, TNFRSF1A, TNF, TNFRSF1B
25
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.2IL6, IL10, TNF, TNFRSF1A
268.2TNF, IL1A, IL6, IL10
278.2TNF, IL10, IL1A, IL6
288.2IL6, IL10, IL1A, TNF
29
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.2IL10, TNF, IL6, IL1A
308.2LTA, TNFRSF1A, IL6, TNFRSF1B, TNF
31
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.2LTA, TNFRSF1B, TNFRSF1A, IL6, TNF
328.2LTA, IL6, IL1R1, TNFRSF1A, TNF
338.0IL10, IL10RA, IL6, IL1A, TNF
34
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
7.9TNFRSF1A, IL1R1, LTA, TNF, TNFSF10, TNFRSF1B
357.9LTA, IL1A, IL6, IL10, TNF
36
Show member pathways
7.8TNFRSF1A, LTA, IL1A, TNFRSF10A, IL1R1, TNFSF10
37
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
7.8TNF, TNFRSF1A, LTA, IL1A, IL6, IL1R1
38
Show member pathways
7.6TNFRSF1A, B2M, TNFRSF10A, TNFRSF1B, TNF, LTA
39
Show member pathways
7.6IL6, IL10RA, IL1A, TNF, IL10, TNFRSF1A
407.6IL10, IL1A, TNFRSF1A, IL6, IL10RA, TNF
41
Show member pathways
7.5TNFRSF1A, IL1R1, IL6, TNF, IL1A, TNFRSF1B
42
Show member pathways
7.4TNF, TNFRSF1B, IL6, TNFRSF1A, TNFRSF10A, TNFSF10
43
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
7.4IL6, LTA, TNFRSF1A, TNFRSF10A, TNF, TNFRSF1B
44
Show member pathways
7.3TNFSF10, TNF, TNFRSF1A, IL6, IL1A, LTA
45
Show member pathways
6.4B2M, TNFRSF1B, TNF, TNFRSF1A, IL10, IL6
46
Show member pathways
6.0IL6, IL10, IL1R1, TNFRSF1A, TNF, TNFRSF1B
47
Show member pathways
6.0TNFSF10, TNFRSF10A, TNF, TNFRSF1A, IL1R1, IL10
48
Show member pathways
6.0IL1R1, TNFRSF1A, TNFSF10, TNFRSF10A, TNFRSF1B, TNF
49
Show member pathways
6.0IL6, IL10, LTA, IL1A, IL10RA, TNFRSF10A
50
Show member pathways
6.0TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL1R1, IL10

Compounds for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Compounds related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 202)
idCompoundScoreTop Affiliating Genes
1cuprophan449.0TNFRSF1A, TNFRSF1B, B2M, IL1R1
2rantes449.0IL1A, TNFRSF1A, TNFRSF1B, IL1R1, IL10
3tenidap44 289.8TNF, IL1R1, IL6, IL1A
412-o-tetradecanoylphorbol 13-acetate448.7IL1A, TNFRSF1A, TKT, IL1R1, TNFRSF1B, LTA
5fmlp448.6LTA, TNFRSF1A, TKT, IL1A, TNF, TNFRSF1B
6il-12448.5IL1R1, IL10, IL6, TNF
7leflunomide44 50 1110.4TNF, TNFRSF1A, IL1R1, IL6
8imiquimod44 61 28 1111.4IL10, IL6, TNF, IL1A
9lipoteichoic acid448.4TNF, LTA, IL6, IL10, IL1R1
10okt3448.3TNF, TNFRSF1A, IL10, IL6, LTA
11polymyxin b448.3IL6, IL10, IL1A, TNF
12adalimumab44 50 1110.3IL6, IL10, IL1R1, TNFRSF1A, TNF
13ionomycin448.2TNFSF10, LTA, IL1A, TNFRSF1A, TNF, IL10
14chloroquine44 2 50 28 1112.2TNFRSF1B, IL10, IL1R1, TNFRSF1A, B2M, TNF
15ccl344 289.2IL1R1, IL10, IL6, IL1A, TNF
16prednisolone44 28 1110.1LTA, IL6, IL10, TNF, IL1R1
17herbimycin a44 619.1TNF, IL6, IL1A, TKT, LTA, TNFRSF1A
18cisplatin44 50 61 1111.0B2M, TKT, TNFRSF1B, IL1R1, TNFRSF1A, TNFSF10
19pentoxifylline44 119.0LTA, IL1R1, IL10, IL1A, IL6, TNF
20h2o2448.0TNF, TNFSF10, LTA, IL1A, IL1R1, TNFRSF1A
21norepinephrine44 24 119.9TNFRSF1B, TNFRSF1A, TKT, IL1A, IL6, IL1R1
22curcumin447.9TNFRSF1A, TNFRSF1B, TNFSF10, TNF, IL1A, IL6
23groalpha447.9IL10, IL6, IL1A, TNF
24infliximab44 50 119.8TNF, TNFRSF1A, IL1R1, IL10, IL6, LTA
25etanercept44 50 119.8IL10, IL6, LTA, IL1R1, TNFRSF1A, TNFRSF1B
26hydrocortisone44 2 61 1110.8IL1A, IL6, IL10, IL1R1, TNF
27rituximab44 50 119.6B2M, TNF, IL1R1, IL10, IL6, TNFSF10
28il 10447.5TNFRSF1B, TNF, IL1R1, IL10, IL6, IL10RA
29sb 20358044 618.4TNFSF10, TNF, TNFRSF1A, IL1R1, IL10, IL6
30ivig447.4TNF, TNFRSF1A, IL1R1, IL10, IL1A, LTA
31endotoxin447.4TNFRSF1B, TNFRSF1A, IL1A, IL6, IL10, IL1R1
32cholesterol44 28 24 1110.4TNFRSF1B, LTA, IL6, IL1R1, B2M, TNFRSF1A
33vitamin d447.4IL1R1, B2M, TNFRSF1B, IL1A, LTA, SLC11A1
34calcitriol44 61 24 1110.3B2M, IL10, TNF, TNFRSF1A, IL6, IL1A
35methotrexate50 44 119.2IL6, TNFSF10, TNFRSF1B, TNF, TKT, IL1R1
36estrogen447.2TNFRSF1A, LTA, TNFSF10, TKT, IL6, IL1R1
37thymidine44 248.2IL10, IL6, IL1R1, TKT, B2M, TNF
38testosterone44 61 24 1110.2TNFRSF1B, IL1A, IL6, IL1R1, B2M, TNFSF10
39actinomycin d447.1LTA, IL1A, IL6, IL1R1, TNFRSF1A, TNFRSF1B
40indomethacin44 28 61 1110.1IL1A, B2M, TNFSF10, TNF, TNFRSF1A, IL1R1
41serine447.0B2M, TNFSF10, TNF, IL1R1, IL10RA, TNFRSF1A
42neopterin446.7LTA, IL1A, B2M, TNFRSF1B, TNF, TNFRSF1A
43dexamethasone44 50 28 119.6TNFSF10, TNFRSF10A, IL6, LTA, IL1A, IL10
44nitric oxide44 24 118.4SLC11A1, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A, IL1R1
45pge2446.3TNF, TNFRSF1A, IL1R1, IL10, IL6, IL1A
46cyclosporin a44 28 618.3TNFRSF1B, LTA, IL1A, B2M, TNFSF10, TNF
47thalidomide44 50 61 119.3IL1A, IL6, TNFRSF1A, B2M, TNFSF10, TNFRSF10A
48retinoic acid44 247.2TNFRSF10A, TNFSF10, B2M, TNFRSF1B, TNF, TNFRSF1A
49vegf445.9IL6, IL1R1, TNFRSF1A, TNF, TNFRSF1B, TNFSF10
50cycloheximide445.7B2M, TNFSF10, TNFRSF10A, LTA, TNFRSF1B, TNF

GO Terms for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Cellular components related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membrane raftGO:0451219.2TNFRSF1A, TNF, TNFRSF1B
2integral component of plasma membraneGO:0058878.5IL1R1, TNFRSF1A, TNF, TNFSF10, SLC11A1
3external side of plasma membraneGO:0098978.2IL6, B2M, TNF
4plasma membraneGO:0058867.8SLC11A1, B2M, IL1R1, TNFRSF1A, TNF, TNFRSF1B
5extracellular regionGO:0055766.7IL1A, B2M, IL6, IL1R1, TNFRSF1A, TNF
6extracellular spaceGO:0056156.6IL10, B2M, TNFSF10, TNF, TNFRSF1A, IL6

Biological processes related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.1LTA, TNF
2positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.0TNF, LTA
3positive regulation of membrane protein ectodomain proteolysisGO:0510449.9TNF, TNFRSF1B
4positive regulation of cytokine productionGO:0018199.9SLC11A1, TNF
5protein import into nucleus, translocationGO:0000609.8SLC11A1, TNF
6cellular response to estradiol stimulusGO:0713929.8TNFRSF1A, IL10
7positive regulation of interferon-gamma productionGO:0327299.8LTA, SLC11A1, TNF
8receptor biosynthetic processGO:0328009.8IL10, TNF
9negative regulation of cytokine secretion involved in immune responseGO:0027409.8IL10, TNF
10extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.7TNFRSF10A, TNF, TNFRSF1A
11intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.7TNFRSF1A, TNF, TNFRSF1B
12response to molecule of bacterial originGO:0022379.7IL10, B2M
13defense response to protozoanGO:0428329.6IL6, SLC11A1
14defense response to bacteriumGO:0427429.6SLC11A1, IL10, TNFRSF1A
15negative regulation of growth of symbiont in hostGO:0441309.6LTA, IL10, TNF
16positive regulation of protein import into nucleus, translocationGO:0331609.6IL6, TNFRSF1A
17positive regulation of mitosisGO:0458409.5TNF, IL1A
18negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.5IL1A, TNF
19defense response to Gram-negative bacteriumGO:0508299.5SLC11A1, IL6
20response to hypoxiaGO:0016669.5TNF, TNFRSF1A, LTA
21epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.5TNF, IL6
22negative regulation of interleukin-6 productionGO:0327159.5TNF, TNFRSF1A, IL10
23negative regulation of lipid storageGO:0108889.5TNF, IL6
24positive regulation of cytokine secretionGO:0507159.4TNF, IL10, IL1A
25apoptotic signaling pathwayGO:0971909.4TNFSF10, TNF, TNFRSF1A
26positive regulation of chemokine productionGO:0327229.4IL6, TNF
27response to amino acidGO:0432009.3IL6, TNFRSF1A
28positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.3TNFRSF1A, TNF, TNFSF10
29response to activityGO:0148239.3IL10, TNF
30immune responseGO:0069559.3IL1A, IL1R1, TNFRSF1B, TNFSF10
31defense response to Gram-positive bacteriumGO:0508309.3LTA, IL6, TNF
32humoral immune responseGO:0069599.2TNF, IL6, LTA
33response to insulinGO:0328689.1TNFSF10, IL10, IL6
34response to glucocorticoidGO:0513849.0IL6, IL10, TNF
35response to lipopolysaccharideGO:0324968.9TNFRSF1A, IL6, IL10RA, SLC11A1, LTA
36positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9TNF, IL10, IL6
37positive regulation of nitric oxide biosynthetic processGO:0454298.8IL6, TNF
38positive regulation of apoptotic processGO:0430658.8LTA, IL6, TNF, TNFSF10
39apoptotic processGO:0069158.6TNFSF10, TNFRSF10A, TNF, TNFRSF1A, IL1A, LTA
40cytokine-mediated signaling pathwayGO:0192218.4B2M, TNFRSF1A, IL6, IL10RA, IL1A
41response to drugGO:0424938.1LTA, IL6, IL10, TNF, B2M
42positive regulation of transcription from RNA polymerase II promoterGO:0459448.0SLC11A1, IL1A, IL6, IL10, TNFRSF1A, TNF
43inflammatory responseGO:0069547.7SLC11A1, IL1A, IL6, IL10, TNFRSF1A, TNF

Molecular functions related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:0050319.8TNFRSF1A, TNFRSF1B
2tumor necrosis factor receptor bindingGO:0051649.2TNFSF10, TNF, LTA
3protease bindingGO:0020209.2IL1R1, TNFRSF1A, TNF
4cytokine activityGO:0051257.5LTA, IL1A, IL6, IL10, TNF, TNFSF10
5protein bindingGO:0055155.8B2M, TNFSF10, TNFRSF10A, TNFRSF1B, TNF, TNFRSF1A

Products for genes affiliated with Post-Transplant Lymphoproliferative Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
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46OMIM
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62UMLS
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