PTLD
MCID: PST046
MIFTS: 54

Post-Transplant Lymphoproliferative Disease (PTLD) malady

Blood, Cancer, Immune categories

Summaries for Post-Transplant Lymphoproliferative Disease

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Post-transplant lymphoproliferative disorder (PTLD) is the name given to a B-cell proliferation due to... more...

MalaCards: Post-Transplant Lymphoproliferative Disease, also known as post-transplant lymphoproliferative disorder, is related to acute leukemia and t-cell leukemia. An important gene associated with Post-Transplant Lymphoproliferative Disease is IL10RA (interleukin 10 receptor, alpha), and among its related pathways are B cell receptor signaling pathway and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds indomethacin and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are adipose tissue and vision/eye.

Aliases & Classifications for Post-Transplant Lymphoproliferative Disease

Sources:
43NIH Rare Diseases, 31LifeMap Discovery™, 49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
posttransplant lymphoproliferative disease:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

post-transplant lymphoproliferative disease 43 31
post-transplant lymphoproliferative disorder 61
posttransplant lymphoproliferative disease 49
ptld 49


External Ids:

ICD10 via Orphanet26 D47.9
SNOMED-CT via Orphanet58 254290004
UMLS via Orphanet62 C0432487

Related Diseases for Post-Transplant Lymphoproliferative Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Post-Transplant Lymphoproliferative Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia30.5TKT, TNFSF10, TNFRSF10A
2t-cell leukemia30.5TNFRSF10A, TNFRSF1A, TNFSF10, LTA, IL1A, TKT
3tonsillitis30.3IL1A, LTA
4cystic fibrosis30.3IL1R1, HLA-A
5thrombocytopenia30.3IL6, IL1A, IL1R1
6graft versus host disease30.3TNFRSF1A, TNF, HLA-A, LTA, IL10, IL1R1
7anaplastic large cell lymphoma29.9TNFRSF1A
8hematopoietic stem cell transplantation10.6
9hepatitis d10.5
10central nervous system lymphoma10.4
11hepatitis a10.4
12acute liver failure10.2
13renal wilms' tumor10.2
14hemophagocytic lymphohistiocytosis10.2
15wiskott-aldrich syndrome10.2
16acute t cell leukemia10.2
17adult t-cell leukemia10.2
18autoimmune hemolytic anemia10.2
19mycosis fungoides10.2
20cerebral lymphoma10.2
21adult lymphoma10.2
22down syndrome10.2
23invasive aspergillosis10.2
24aspergillosis10.2
25wilms tumor10.2
26bone marrow necrosis10.2
27central nervous system lymphoma, primary10.2
28leukoplakia10.2
29oral leukoplakia10.2
30leukemia/lymphoma, t-cell10.2
31mixed-type autoimmune hemolytic anemia10.2
32omenn syndrome10.2
33intussusception10.2
34autoimmune hepatitis10.2
35breast lymphoma10.2
36aplastic anemia10.2
37tongue disease10.2
38blastic plasmacytoid dendritic cell10.2
39peripheral t-cell lymphoma10.2
40refractory anemia10.2
41liver lymphoma10.2
42infectious mononucleosis10.2
43lymphoblastic lymphoma10.2
44typhoid fever10.0SLC11A1
45leprosy10.0SLC11A1
46dengue hemorrhagic fever10.0LTA
47viral hepatitis10.0TNFRSF1A
48myocarditis10.0TNFRSF1B
49essential hypertension10.0TNFRSF1B
50adenoma10.0TNFRSF10A

Graphical network of the top 20 diseases related to Post-Transplant Lymphoproliferative Disease:



Diseases related to post-transplant lymphoproliferative disease

Clinical Features for Post-Transplant Lymphoproliferative Disease

Drugs & Therapeutics for Post-Transplant Lymphoproliferative Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™
See all sources

Approved drugs:

Search CenterWatch for Post-Transplant Lymphoproliferative Disease

Drug clinical trials:

Search ClinicalTrials for Post-Transplant Lymphoproliferative Disease

Search NIH Clinical Center for Post-Transplant Lymphoproliferative Disease

Search CenterWatch for Post-Transplant Lymphoproliferative Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Post-Transplant Lymphoproliferative Disease:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Post-Transplant Lymphoproliferative Disease:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Post-Transplant Lymphoproliferative Disease

Anatomical Context for Post-Transplant Lymphoproliferative Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Post-Transplant Lymphoproliferative Disease:

33
Skin, Liver, Tongue, Kidney, Lung, Bone marrow, Whole blood, Heart, Small intestine, Breast, Tonsil, T cells, B lymphoblasts, B cells

Animal Models for Post-Transplant Lymphoproliferative Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Post-Transplant Lymphoproliferative Disease:

37 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.3IL1R1
2MP:000539110.1IL1R1, TNFRSF1B
3MP:00036319.9LTA, TNFRSF1A
4MP:00053699.9TNFRSF1A, TNFRSF1B
5MP:00107719.2TNFRSF1B, IL1R1, IL6
6MP:00053889.1TNFRSF1B, LTA, IL1R1, IL6
7MP:00053768.9TNFRSF1B, TNFRSF1A, B2M, LTA, IL10RA, IL1R1
8MP:00053908.8TNFRSF1B, TNFRSF1A, TNFSF10, LTA, IL6
9MP:00053797.4TNFRSF1A, TNF, B2M, LTA, IL1R1, IL6
10MP:00020067.4SLC11A1, TNFRSF1B, TNFRSF1A, TNFSF10, TNF, IL10
11MP:00053817.3TNFRSF1B, TNFRSF1A, TNF, B2M, IL10RA, IL10
12MP:00053866.6TNFRSF1B, TNFRSF1A, TNF, LTA, IL10, IL1R1
13MP:00053846.6TNF, TNFSF10, TNFRSF1A, TNFRSF1B, B2M, LTA
14MP:00053706.4TNFRSF1B, TNFRSF1A, TNFSF10, TNF, B2M, LTA
15MP:00053856.4TNFRSF1B, TNFRSF1A, TNF, B2M, LTA, IL10
16MP:00053976.1B2M, TNF, TNFSF10, TNFRSF1A, TNFRSF1B, LTA
17MP:00053876.1B2M, TNF, TNFSF10, TNFRSF1A, TNFRSF1B, LTA
18MP:00107686.0TNFRSF1B, TNFRSF1A, TNFSF10, TNF, B2M, LTA

Publications for Post-Transplant Lymphoproliferative Disease

Sources:
51PubMed
See all sources

Articles related to Post-Transplant Lymphoproliferative Disease:

(show top 50)    (show all 142)
idTitleAuthorsYear
1
Epistaxis in a kidney transplant recipient: an uncommon presentation of post-transplant lymphoproliferative disease. (23577919)
2013
2
Risk factors for Epstein Barr virus related post-transplant lymphoproliferative disease after allogeneic hematopoietic stem cell transplantation. (24056821)
2013
3
Sustained response to intrathecal rituximab in EBV associated Post-transplant lymphoproliferative disease confined to the central nervous system following haematopoietic stem cell transplant. (21584931)
2012
4
Plasmacytoma-like post-transplant lymphoproliferative disorder, a rare subtype of monomorphic B-cell post-transplant lymphoproliferation, is associated with a favorable outcome in localized as well as in advanced disease: a prospective analysis of 8 cases. (21719885)
2011
5
Post-transplant lymphoproliferative disease in pediatric lung transplant recipients: recent advances in monitoring. (19017289)
2009
6
Post-transplant lymphoproliferative disease. (17891420)
2009
7
Hepatitis B virus reactivation is a risk factor for development of post-transplant lymphoproliferative disease after liver transplantation. (19664018)
2009
8
Post-transplant lymphoproliferative disease presenting as a mass in the left ventricle in a heart transplant recipient at long-term follow-up. (19201350)
2009
9
Associations of serum EBV DNA and gammopathy with post-transplant lymphoproliferative disease. (19200218)
2009
10
An unusual case of forehead post-transplant lymphoproliferative disease. (18084267)
2008
11
Ultrasound in abdominal and soft-tissue childhood PTLD (post-transplant lymphoproliferative disease). (17199182)
2007
12
Post-transplant lymphoproliferative disease in children following solid organ transplant and rituximab--the final answer? (17663676)
2007
13
Case-control study of risk factors for the development of post-transplant lymphoproliferative disease in a pediatric heart transplant cohort. (17239124)
2007
14
Post-transplant lymphoproliferative disease and other Epstein-Barr virus diseases in allogeneic haematopoietic stem cell transplantation after introduction of monitoring of viral load by polymerase chain reaction. (17366054)
2007
15
Treatment and outcomes of post-transplant lymphoproliferative disease: a single institution study. (17022049)
2007
16
Slc11a1 (formerly Nramp1) polymorphisms and susceptibility to post-transplant lymphoproliferative disease following pediatric liver transplantation. (16734634)
2006
17
Late-onset post-transplant lymphoproliferative disease: a report of four patients in one center. (16840223)
2006
18
Posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis in a lung transplant patient. (16546589)
2006
19
Post transplant lymphoproliferative disease: detection of tumor by Tc99m sestaMIBI and treatment with rituximab. (15592492)
2005
20
Induction of pre-transplant Epstein-Barr virus (EBV) infection by donor blood transfusion in EBV-seronegative recipients may reduce risk of post-transplant lymphoproliferative disease in adolescent renal transplant patients: report of two cases. (16390402)
2005
21
Asymptomatic small bowel intussusception associated with post-transplant lymphoproliferative disease. (15049803)
2004
22
Complete immunosuppressive withdrawal as a uniform approach to post-transplant lymphoproliferative disease in pediatric liver transplantation. (15176965)
2004
23
Quantification of Epstein-Barr viral load and determination of a cut-off value to predict the risk of post-transplant lymphoproliferative disease in a renal transplant cohort. (15020282)
2004
24
Serial detection of Epstein-Barr virus DNA in sera and peripheral blood leukocyte samples of pediatric renal allograft recipients with persistent mononucleosis-like symptoms defines patients at risk to develop post-transplant lymphoproliferative disease. (12581328)
2003
25
Initial spontaneous remission of posttransplantation Epstein Barr virus-related B-cell lymphoproliferative disorder of the skin in a renal transplant recipient: case report and review of the literature on cutaneous B-cell posttransplantation lymphoproliferative disease. (12357204)
2002
26
Identification of early antigen BZLF1/ZEBRA protein of Epstein-Barr virus can predict the effectiveness of antiviral treatment in patients with post-transplant lymphoproliferative disease. (12199794)
2002
27
Role of Epstein-Barr virus DNA load monitoring in prevention and early detection of post-transplant lymphoproliferative disease. (12153173)
2002
28
Low-dose chemotherapy for children with post-transplant lymphoproliferative disease. (11785850)
2002
29
The beta2-microglobulin/cystatin C ratio--a potential marker of post-transplant lymphoproliferative disease. (12508963)
2002
30
Epstein-Barr viral load as a tool to diagnose and monitor post-transplant lymphoproliferative disease. (11785844)
2002
31
The Epstein-Barr virus and post-transplant lymphoproliferative disease: interplay of immunosuppression, EBV, and the immune system in disease pathogenesis. (11395971)
2001
32
Management of Epstein-Barr virus-induced post-transplant lymphoproliferative disease in recipients of solid organ transplantation. (12099356)
2001
33
Post-transplant lymphoproliferative disease in children. (11472603)
2001
34
Treatment of post-transplant lymphoproliferative disease with induction chemotherapy followed by haploidentical peripheral blood stem cell transplantation and Rituximab. (11277182)
2001
35
Epstein--Barr virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrate. (11493400)
2001
36
Primary tacrolimus (FK506) therapy and the long-term risk of post-transplant lymphoproliferative disease in pediatric liver transplant recipients. (11560756)
2001
37
Epstein-Barr virus load monitoring: its role in the prevention and management of post-transplant lymphoproliferative disease. (11395973)
2001
38
Rising incidence of post-transplant lymphoproliferative disease in kidney transplant recipients. (11578286)
2001
39
Early post-transplant lymphoproliferative disease following heart transplantation in the absence of lymphocytolytic induction therapy. (10967276)
2000
40
Verotoxin targets lymphoma infiltrates of patients with post-transplant lymphoproliferative disease. (10996204)
2000
41
Treatment of post-transplant lymphoproliferative disease with rituximab monoclonal antibody after lung transplantation. (10568575)
1999
42
Significance of Epstein-Barr virus status and post-transplant lymphoproliferative disease in pediatric thoracic transplantation. (10389130)
1999
43
Post-transplant lymphoproliferative disease. (9829519)
1998
44
Increased beta 2-microglobulin (B2M) is useful in the detection of post-transplant lymphoproliferative disease (PTLD). (9067691)
1997
45
Treatment and prognosis of post-transplant lymphoproliferative disease. (9869878)
1997
46
Renal allograft involvement by Epstein-Barr virus associated post-transplant lymphoproliferative disease. (8619421)
1996
47
Use of quantitative PCR to predict onset of Epstein-Barr viral infection and post-transplant lymphoproliferative disease after intestinal transplantation in children. (8908044)
1996
48
Interleukin-10 production by a B-cell line derived from human post-transplant lymphoproliferative disease. (7750924)
1995
49
Factors associated with the development of post-transplant lymphoproliferative disease (PTLD) in Epstein-Barr virus (EBV)-seronegative adult liver transplant recipients. (11271213)
1994
50
The potential role of cytokines in the pathogenesis of Epstein-Barr virus associated post-transplant lymphoproliferative disease. (7873995)
1994

Genetic Variations for Post-Transplant Lymphoproliferative Disease

Expression for genes affiliated with Post-Transplant Lymphoproliferative Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Post-Transplant Lymphoproliferative Disease

Search GEO for disease gene expression data for Post-Transplant Lymphoproliferative Disease.

Pathways for genes affiliated with Post-Transplant Lymphoproliferative Disease

Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 54Reactome, 53R&D Systems, 56SinoBiological
See all sources

Pathways related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1IL1A
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.1IL1A
3
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9.9IL1A, IL10RA
49.9IL1R1, TNFRSF1A
5
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9.6TNFRSF1B, TNFRSF1A, LTA
69.3IL6, TNFSF10, TNFRSF10A
7
Hide members
9.1TNFRSF10A, TNFRSF1B, TNFSF10, LTA, IL10RA
8
Hide members
9.1TNFRSF10A, TNFRSF1A, TNFSF10, LTA, IL10RA
99.0TNFRSF1B, TNFRSF1A, TNF
109.0TNFRSF1B, TNFRSF1A, TNF
11
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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9.0TNF, TNFRSF1A, TNFRSF1B
12
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9.0TNF, TNFRSF1A, TNFRSF1B
13
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9.0IL1A, IL10RA, TNFRSF1A, TNFRSF1B, TNFRSF10A
14
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9.0TNF, TNFSF10, TNFRSF1A
15
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8.8IL1R1, IL10RA, LTA, TNFRSF1A, TNFRSF1B, TNFRSF10A
168.8TNFRSF1A, TNF, LTA, IL1R1
17
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8.8TNFRSF1B, TNFRSF1A, TNF, LTA
18
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8.7TNFRSF10A, TNFRSF1B, TNFRSF1A, LTA, IL6
198.7B2M, HLA-A, TNF
208.7IL1A, IL1R1, TNF, TNFRSF1A
21
Hide members
8.6IL10, TNF, TNFRSF1A, TNFRSF1B
228.6TNF, IL10, IL6
23
Apoptosis and survival Apoptotic TNF-family pathways
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8.4TNFRSF10A, TNFRSF1B, TNFRSF1A, TNFSF10, TNF
24
Development PDGF signaling via STATs and NF-kB
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8.4IL6, IL10, IL10RA, TNF
25
Immune response Bacterial infections in normal airways
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8.4TNF, IL1R1, IL1A, IL6
26
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8.4IL6, IL1A, IL1R1, TNF
278.4IL6, IL1A, IL1R1, TNF
288.4IL6, IL1A, IL1R1, TNF
29
Hide members
8.4IL6, IL10, LTA, TNF
308.3TNF, IL10, IL1R1, IL6
31
Hide members
8.3IL6, IL10, TNF, TNFRSF1A
328.2TNF, IL10, IL1A, IL6
338.2TNF, IL10, IL1A, IL6
34
Hide members
8.2HLA-A, B2M, IL1R1, IL1A, IL6
35
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8.1IL6, LTA, TNF, TNFRSF1A, TNFRSF1B
368.1TNFRSF1B, TNFRSF1A, TNF, LTA, IL6
378.1TNFRSF1B, TNFRSF1A, TNF, LTA, IL1R1, IL1A
388.0TNF, IL10RA, IL10, IL1A, IL6
39
Hide members
8.0B2M, HLA-A, TNF, TNFSF10, TNFRSF1A
408.0TNF, LTA, IL10, IL1A, IL6
41
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7.9TNFRSF10A, TNFRSF1B, TNFRSF1A, TNFSF10, TNF, LTA
42
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7.8TNFRSF10A, TNFRSF1A, TNFSF10, TNF, LTA, IL1R1
437.7TNFRSF1A, TNF, IL10RA, IL10, IL1A, IL6
44
Hide members
7.6TNFRSF10A, TNFRSF1B, TNFRSF1A, TNFSF10, TNF, LTA
45
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7.5TNFRSF10A, TNFRSF1B, TNFRSF1A, TNFSF10, TNF, LTA
46
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7.5TNFRSF1B, TNFRSF1A, TNF, LTA, IL1R1, IL1A
47
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7.2TNFRSF10A, TNFRSF1B, TNFRSF1A, TNFSF10, TNF, HLA-A
48
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7.0TNFRSF10A, TNFRSF1A, TNFSF10, TNF, HLA-A, LTA
49
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6.3IL10RA, LTA, TNF, TNFSF10, TNFRSF1A, TNFRSF1B
50
Hide members
6.1IL6, TNFRSF1B, TNFRSF1A, TNF, HLA-A, B2M

Compounds for genes affiliated with Post-Transplant Lymphoproliferative Disease

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 161)
idCompoundScoreTop Affiliating Genes
1indomethacin45 60 29 1113.6IL1R1
2pentoxifylline45 1111.3LTA, IL1R1
3endotoxin4510.3TNFRSF1B, TNFRSF1A
4tenidap45 2911.2IL1A, IL1R1
5cycloheximide4510.1LTA, TKT
6prednisolone45 29 1112.0IL1R1, LTA
7estrogen459.9TNFRSF1B
8ivig459.6IL1A, IL1R1, TNFRSF1A, TNFRSF1B
9norepinephrine45 11 2411.6TKT, TNFRSF1A
10fmlp459.6IL1A, TKT, TNFRSF1B
11tri (d)459.6TNFRSF1A, TNFSF10, TNFRSF10A
12cuprophan459.4IL1R1, TNFRSF1B, B2M, TNFRSF1A
13gm-csf45 2910.4TNF, IL10
14dexamethasone45 50 29 1111.8TNFSF10, LTA, IL1R1, IL6, TNFRSF10A, TNFRSF1B
15cyclosporin a45 29 6010.7TNFRSF1B, TNFSF10, HLA-A, IL1R1, LTA, B2M
16adalimumab45 50 1110.7IL10, TNF, IL6, IL1R1
17il-12458.6IL10, IL6, TNF, IL1R1
1812-o-tetradecanoylphorbol 13-acetate458.6TKT, IL1A, IL1R1, LTA, TNFRSF1B, TNFRSF1A
19leflunomide50 45 1110.6TNFRSF1A, TNF, IL1R1, IL6
20imiquimod45 29 60 1111.5IL6, IL1A, TNF, IL10
21cdp571458.5TNF, IL10, IL6
22polymyxin b458.5TNF, IL10, IL1A, IL6
23lipoteichoic acid458.4IL6, IL1R1, IL10, LTA, TNF
24groalpha458.4IL10, TNF, IL1A, IL6
25okt3458.4IL6, LTA, IL10, TNF, TNFRSF1A
26ccl345 299.3TNF, IL10, IL1R1, IL6, IL1A
27ionomycin458.3IL1A, IL10, LTA, TNF, TNFSF10, TNFRSF1A
28cisplatin45 50 60 1111.3TKT, IL1R1, B2M, TNFRSF1B, TNFRSF1A, TNFRSF10A
29chloroquine45 2 50 29 1112.3B2M, TNFRSF1B, TNFRSF1A, TNF, IL10, IL1R1
30rantes458.2TNFRSF1A, IL6, IL1A, IL1R1, LTA, TNF
31curcumin458.0TNFRSF1B, IL6, TNFRSF1A, TNF, IL1A, TNFSF10
32cholesterol45 29 11 2411.0TNFRSF1A, IL6, LTA, B2M, TNFSF10, TNFRSF1B
33serine458.0TNF, TNFRSF1A, TNFRSF1B, B2M, IL1R1, IL1A
34rituximab45 50 119.9IL1R1, IL10, TNFSF10, TNF, B2M, IL6
35vitamin d457.9LTA, B2M, IL6, SLC11A1, IL10, IL1R1
36herbimycin a45 608.9LTA, IL1A, TKT, IL6, TNFRSF1A, TNF
37etanercept45 50 119.9TNFRSF1B, TNFRSF1A, TNF, LTA, IL1R1, IL6
38infliximab45 50 119.9IL6, TNFRSF1A, LTA, IL1R1, TNF, IL10
39sb 20358045 608.7TNFSF10, TNFRSF1A, IL1R1, IL10, IL6, IL1A
40il 10457.6IL6, TNFRSF1B, TNF, LTA, IL10RA, IL10
41calcitriol45 60 11 2410.6IL1A, IL6, IL10, LTA, B2M, TNF
42testosterone45 60 11 2410.6TNFRSF1B, IL1R1, B2M, IL1A, TNFRSF1A, TNFSF10
43actinomycin d457.3IL1A, LTA, TNF, TNFRSF10A, IL1R1, TNFRSF1B
44methotrexate45 50 119.3TNFSF10, TNFRSF1B, TNFRSF1A, TNF, IL1R1, IL6
45thymidine45 248.2IL6, IL1A, IL1R1, IL10, B2M, TNF
46neopterin457.1LTA, TNFRSF1B, TNFRSF1A, IL10, IL1R1, IL1A
47thalidomide45 50 60 119.7IL6, IL1A, IL1R1, IL10, B2M, TNF
48nitric oxide45 11 248.7TNF, TNFRSF1A, TNFRSF1B, TNFRSF10A, TNFSF10, LTA
49retinoic acid45 247.3TKT, TNF, TNFRSF1B, TNFRSF1A, IL6, IL1A
50vegf456.2TKT, B2M, TNFRSF1B, TNFRSF1A, TNFSF10, TNF

GO Terms for genes affiliated with Post-Transplant Lymphoproliferative Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic vesicle membraneGO:0306709.2HLA-A, B2M, SLC11A1
2MHC class I protein complexGO:0426129.2B2M, HLA-A
3membrane raftGO:0451219.0TNF, TNFRSF1A, TNFRSF1B
4integral to plasma membraneGO:0058877.8TNFRSF1A, TNFSF10, TNF, HLA-A, IL1R1, SLC11A1
5extracellular regionGO:0055767.0TNFRSF1B, TNFRSF1A, TNFSF10, TNF, B2M, IL1R1
6extracellular spaceGO:0056157.0IL6, TNFRSF1A, TNFSF10, TNF, B2M, LTA

Biological processes related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.4IL10
2response to molecule of bacterial originGO:0022379.8IL10, B2M
3positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.7LTA, TNF
4positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.7LTA, TNF
5positive regulation of protein import into nucleus, translocationGO:0331609.7IL6, TNFRSF1A
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.7B2M, HLA-A
7cellular response to estradiol stimulusGO:0713929.6TNFRSF1A, IL10
8defense response to bacteriumGO:0427429.6TNFRSF1A, IL10, SLC11A1
9defense response to protozoanGO:0428329.6SLC11A1, IL6
10receptor biosynthetic processGO:0328009.6TNF, IL10
11positive regulation of interferon-gamma productionGO:0327299.5SLC11A1, LTA, TNF
12extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.5TNFRSF10A, TNFRSF1A, TNF
13positive regulation of membrane protein ectodomain proteolysisGO:0510449.4TNF, TNFRSF1B
14response to lipopolysaccharideGO:0324969.4TNFRSF1A, LTA, IL6, SLC11A1
15negative regulation of growth of symbiont in hostGO:0441309.4TNF, LTA, IL10
16negative regulation of interleukin-6 productionGO:0327159.3IL10, TNF, TNFRSF1A
17negative regulation of lipid storageGO:0108889.3IL6, TNF
18epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.3IL6, TNF
19activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.3TNFRSF10A, TNFSF10, TNF
20positive regulation of cytokine secretionGO:0507159.2IL1A, IL10, TNF
21defense response to Gram-positive bacteriumGO:0508309.1TNF, LTA, IL6
22humoral immune responseGO:0069599.1IL6, LTA, TNF
23immune responseGO:0069559.0TNFRSF1B, TNFSF10, HLA-A, IL1R1, IL1A
24apoptotic signaling pathwayGO:0971909.0TNF, TNFSF10, TNFRSF1A
25response to glucocorticoid stimulusGO:0513848.9TNF, IL10, IL6
26positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9IL6, IL10, TNF
27positive regulation of chemokine productionGO:0327228.7IL6, TNF
28positive regulation of apoptotic processGO:0430658.7TNFSF10, TNF, LTA, IL6
29cytokine-mediated signaling pathwayGO:0192218.6IL6, IL1A, B2M, HLA-A, TNFRSF1A
30apoptotic processGO:0069158.5TNFRSF10A, TNFRSF1A, TNFSF10, TNF, LTA, IL1A
31response to drugGO:0424938.3TNF, B2M, LTA, IL10, IL6
32positive regulation of transcription from RNA polymerase II promoterGO:0459448.0TNFRSF1A, TNF, IL10, IL1A, IL6, SLC11A1
33inflammatory responseGO:0069547.8SLC11A1, TNFRSF1B, TNFRSF1A, TNF, IL10, IL1A

Molecular functions related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:0050319.9TNFRSF1A, TNFRSF1B
2tumor necrosis factor receptor bindingGO:0051648.9TNFSF10, TNF, LTA
3protease bindingGO:0020208.8IL1R1, TNF, TNFRSF1A
4cytokine activityGO:0051257.6IL6, IL1A, IL10, LTA, TNF, TNFSF10

Products for genes affiliated with Post-Transplant Lymphoproliferative Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Post-Transplant Lymphoproliferative Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet