PTLD
MCID: PST046
MIFTS: 49

Post-Transplant Lymphoproliferative Disease (PTLD) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Post-Transplant Lymphoproliferative Disease

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63Wikipedia, 32MalaCards
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Wikipedia:63 Post-transplant lymphoproliferative disorder (PTLD) is the name given to a B-cell proliferation due to... more...

MalaCards: Post-Transplant Lymphoproliferative Disease, also known as post-transplant lymphoproliferative disorder, is related to hepatitis and leukemia. An important gene associated with Post-Transplant Lymphoproliferative Disease is IL10RA (interleukin 10 receptor, alpha), and among its related pathways are B cell receptor signaling pathway and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds indomethacin and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include b cells and bone, and related mouse phenotypes are adipose tissue and vision/eye.

Aliases & Classifications for Post-Transplant Lymphoproliferative Disease

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42NIH Rare Diseases, 30LifeMap Discovery™, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
posttransplant lymphoproliferative disease:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

post-transplant lymphoproliferative disease 42 30
post-transplant lymphoproliferative disorder 60
posttransplant lymphoproliferative disease 48
ptld 48


External Ids:

ICD10 via Orphanet26 D47.9
SNOMED-CT via Orphanet57 254290004, 450943001
UMLS via Orphanet61 C0432487

Related Diseases for Post-Transplant Lymphoproliferative Disease

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17GeneCards, 18GeneDecks
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Diseases related to Post-Transplant Lymphoproliferative Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.6HLA-A, TKT, LTA
2leukemia30.6TNFRSF10A, HLA-A, LTA, IL6, IL1A, IL1R1
3acute leukemia30.5TNFRSF10A, TKT, TNFSF10
4t-cell leukemia30.5TNFRSF10A, TNFRSF1A, TNFSF10, LTA, TKT, IL1A
5hodgkin's lymphoma30.5LTA, HLA-A, TNFRSF1B, TNFRSF1A
6gingivitis30.3IL1A
7gingival overgrowth30.3IL1A
8myositis30.3IL1A, TNFRSF1B
9tonsillitis30.3LTA, IL1A
10hepatitis b30.3HLA-A, TNFRSF1A
11cystic fibrosis30.3HLA-A, IL1R1
12thrombocytopenia30.3IL1A, IL6, IL1R1
13hepatitis c30.3TNFRSF1B, IL10, TNF, HLA-A
14pneumonia30.2IL6, IL10, TNF, TNFRSF1B
15optic neuritis30.2LTA
16graft versus host disease30.2IL1R1, IL10, TNF, LTA, HLA-A, TNFRSF1A
17anaplastic large cell lymphoma29.9TNFRSF1A
18liver disease10.8
19kidney disease10.4
20central nervous system lymphoma10.4
21myelofibrosis10.4
22breast disease10.4
23central nervous system disease10.4
24nervous system disease10.4
25acute liver failure10.2
26renal wilms' tumor10.2
27hemophagocytic lymphohistiocytosis10.2
28cerebritis10.2
29wiskott-aldrich syndrome10.2
30acute t cell leukemia10.2
31adult t-cell leukemia10.2
32autoimmune hemolytic anemia10.2
33mycosis fungoides10.2
34cerebral lymphoma10.2
35adult lymphoma10.2
36invasive aspergillosis10.2
37aspergillosis10.2
38hemolytic anemia10.2
39intestinal perforation10.2
40lactic acidosis10.2
41intussusception10.2
42autoimmune hepatitis10.2
43breast lymphoma10.2
44hepatitis a10.2
45aplastic anemia10.2
46hepatoblastoma10.2
47intestinal disease10.2
48leukocyte disease10.2
49plasmacytoma10.2
50tongue disease10.2

Graphical network of the top 20 diseases related to Post-Transplant Lymphoproliferative Disease:



Diseases related to post-transplant lymphoproliferative disease

Clinical Features for Post-Transplant Lymphoproliferative Disease

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Drugs & Therapeutics for Post-Transplant Lymphoproliferative Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™
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Approved drugs:

Search CenterWatch for Post-Transplant Lymphoproliferative Disease

Drug clinical trials:

Search ClinicalTrials for Post-Transplant Lymphoproliferative Disease

Search NIH Clinical Center for Post-Transplant Lymphoproliferative Disease

Search CenterWatch for Post-Transplant Lymphoproliferative Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-cell-based therapeutic approaches for Post-Transplant Lymphoproliferative Disease:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Post-Transplant Lymphoproliferative Disease:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Post-Transplant Lymphoproliferative Disease

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Anatomical Context for Post-Transplant Lymphoproliferative Disease

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32MalaCards
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MalaCards organs/tissues related to Post-Transplant Lymphoproliferative Disease:

32
B cells, Bone

Animal Models for Post-Transplant Lymphoproliferative Disease or affiliated genes

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36MGI
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Publications for Post-Transplant Lymphoproliferative Disease

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Genetic Variations for Post-Transplant Lymphoproliferative Disease

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Expression for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Post-Transplant Lymphoproliferative Disease

Search GEO for disease gene expression data for Post-Transplant Lymphoproliferative Disease.

Pathways for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Sources:
29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN, 53Reactome, 52R&D Systems, 55SinoBiological
See all sources

Pathways related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1IL1A
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.1IL1A
3
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9.9IL1A, IL10RA
49.9IL1R1, TNFRSF1A
5
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9.6TNFRSF1B, TNFRSF1A, LTA
69.3IL6, TNFSF10, TNFRSF10A
7
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9.1TNFRSF10A, TNFRSF1B, TNFSF10, LTA, IL10RA
8
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9.1TNFRSF10A, TNFRSF1A, TNFSF10, LTA, IL10RA
99.0TNFRSF1B, TNFRSF1A, TNF
109.0TNFRSF1B, TNFRSF1A, TNF
11
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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9.0TNF, TNFRSF1A, TNFRSF1B
12
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9.0TNF, TNFRSF1A, TNFRSF1B
13
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9.0IL1A, IL10RA, TNFRSF1A, TNFRSF1B, TNFRSF10A
14
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9.0TNF, TNFSF10, TNFRSF1A
15
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8.8IL1R1, IL10RA, LTA, TNFRSF1A, TNFRSF1B, TNFRSF10A
168.8TNFRSF1A, TNF, LTA, IL1R1
17
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8.8TNFRSF1B, TNFRSF1A, TNF, LTA
18
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8.7TNFRSF10A, TNFRSF1B, TNFRSF1A, LTA, IL6
198.7B2M, HLA-A, TNF
208.7IL1A, IL1R1, TNF, TNFRSF1A
21
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8.6IL10, TNF, TNFRSF1A, TNFRSF1B
228.6TNF, IL10, IL6
23
Apoptosis and survival Apoptotic TNF-family pathways
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8.4TNFRSF10A, TNFRSF1B, TNFRSF1A, TNFSF10, TNF
24
Development PDGF signaling via STATs and NF-kB
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8.4IL6, IL10, IL10RA, TNF
25
Immune response Bacterial infections in normal airways
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8.4TNF, IL1R1, IL1A, IL6
26
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8.4IL6, IL1A, IL1R1, TNF
278.4IL6, IL1A, IL1R1, TNF
288.4IL6, IL1A, IL1R1, TNF
29
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8.4IL6, IL10, LTA, TNF
308.3TNF, IL10, IL1R1, IL6
31
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8.3IL6, IL10, TNF, TNFRSF1A
328.2TNF, IL10, IL1A, IL6
338.2TNF, IL10, IL1A, IL6
34
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8.2HLA-A, B2M, IL1R1, IL1A, IL6
35
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8.1IL6, LTA, TNF, TNFRSF1A, TNFRSF1B
368.1TNFRSF1B, TNFRSF1A, TNF, LTA, IL6
378.1TNFRSF1B, TNFRSF1A, TNF, LTA, IL1R1, IL1A
388.0TNF, IL10RA, IL10, IL1A, IL6
39
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8.0B2M, HLA-A, TNF, TNFSF10, TNFRSF1A
408.0TNF, LTA, IL10, IL1A, IL6
41
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7.9TNFRSF10A, TNFRSF1B, TNFRSF1A, TNFSF10, TNF, LTA
42
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7.8TNFRSF10A, TNFRSF1A, TNFSF10, TNF, LTA, IL1R1
437.7TNFRSF1A, TNF, IL10RA, IL10, IL1A, IL6
44
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7.6TNFRSF10A, TNFRSF1B, TNFRSF1A, TNFSF10, TNF, LTA
45
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7.5TNFRSF10A, TNFRSF1B, TNFRSF1A, TNFSF10, TNF, LTA
46
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7.5TNFRSF1B, TNFRSF1A, TNF, LTA, IL1R1, IL1A
47
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7.2TNFRSF10A, TNFRSF1B, TNFRSF1A, TNFSF10, TNF, HLA-A
48
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7.0TNFRSF10A, TNFRSF1A, TNFSF10, TNF, HLA-A, LTA
49
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6.3IL10RA, LTA, TNF, TNFSF10, TNFRSF1A, TNFRSF1B
50
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6.1IL6, TNFRSF1B, TNFRSF1A, TNF, HLA-A, B2M

Compounds for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 161)
idCompoundScoreTop Affiliating Genes
1indomethacin44 59 28 1113.6IL1R1
2pentoxifylline44 1111.3LTA, IL1R1
3endotoxin4410.3TNFRSF1B, TNFRSF1A
4tenidap44 2811.2IL1A, IL1R1
5cycloheximide4410.1LTA, TKT
6prednisolone44 28 1112.0IL1R1, LTA
7estrogen449.9TNFRSF1B
8ivig449.6IL1A, IL1R1, TNFRSF1A, TNFRSF1B
9norepinephrine44 11 2411.6TKT, TNFRSF1A
10fmlp449.6IL1A, TKT, TNFRSF1B
11tri (d)449.6TNFRSF1A, TNFSF10, TNFRSF10A
12cuprophan449.4IL1R1, TNFRSF1B, B2M, TNFRSF1A
13gm-csf44 2810.4TNF, IL10
14dexamethasone44 49 28 1111.8TNFSF10, LTA, IL1R1, IL6, TNFRSF10A, TNFRSF1B
15cyclosporin a44 28 5910.7TNFRSF1B, TNFSF10, HLA-A, IL1R1, LTA, B2M
16adalimumab44 49 1110.7IL10, TNF, IL6, IL1R1
17il-12448.6IL10, IL6, TNF, IL1R1
1812-o-tetradecanoylphorbol 13-acetate448.6TKT, IL1A, IL1R1, LTA, TNFRSF1B, TNFRSF1A
19leflunomide49 44 1110.6TNFRSF1A, TNF, IL1R1, IL6
20imiquimod44 28 59 1111.5IL6, IL1A, TNF, IL10
21cdp571448.5TNF, IL10, IL6
22polymyxin b448.5TNF, IL10, IL1A, IL6
23lipoteichoic acid448.4IL6, IL1R1, IL10, LTA, TNF
24groalpha448.4IL10, TNF, IL1A, IL6
25okt3448.4IL6, LTA, IL10, TNF, TNFRSF1A
26ccl344 289.3TNF, IL10, IL1R1, IL6, IL1A
27ionomycin448.3IL1A, IL10, LTA, TNF, TNFSF10, TNFRSF1A
28cisplatin44 49 59 1111.3TKT, IL1R1, B2M, TNFRSF1B, TNFRSF1A, TNFRSF10A
29chloroquine44 2 49 28 1112.3B2M, TNFRSF1B, TNFRSF1A, TNF, IL10, IL1R1
30rantes448.2TNFRSF1A, IL6, IL1A, IL1R1, LTA, TNF
31curcumin448.0TNFRSF1B, IL6, TNFRSF1A, TNF, IL1A, TNFSF10
32cholesterol44 28 11 2411.0TNFRSF1A, IL6, LTA, B2M, TNFSF10, TNFRSF1B
33serine448.0TNF, TNFRSF1A, TNFRSF1B, B2M, IL1R1, IL1A
34rituximab44 49 119.9IL1R1, IL10, TNFSF10, TNF, B2M, IL6
35vitamin d447.9LTA, B2M, IL6, SLC11A1, IL10, IL1R1
36herbimycin a44 598.9LTA, IL1A, TKT, IL6, TNFRSF1A, TNF
37etanercept44 49 119.9TNFRSF1B, TNFRSF1A, TNF, LTA, IL1R1, IL6
38infliximab44 49 119.9IL6, TNFRSF1A, LTA, IL1R1, TNF, IL10
39sb 20358044 598.7TNFSF10, TNFRSF1A, IL1R1, IL10, IL6, IL1A
40il 10447.6IL6, TNFRSF1B, TNF, LTA, IL10RA, IL10
41calcitriol44 59 11 2410.6IL1A, IL6, IL10, LTA, B2M, TNF
42testosterone44 59 11 2410.6TNFRSF1B, IL1R1, B2M, IL1A, TNFRSF1A, TNFSF10
43actinomycin d447.3IL1A, LTA, TNF, TNFRSF10A, IL1R1, TNFRSF1B
44methotrexate44 49 119.3TNFSF10, TNFRSF1B, TNFRSF1A, TNF, IL1R1, IL6
45thymidine44 248.2IL6, IL1A, IL1R1, IL10, B2M, TNF
46neopterin447.1LTA, TNFRSF1B, TNFRSF1A, IL10, IL1R1, IL1A
47thalidomide44 49 59 119.7IL6, IL1A, IL1R1, IL10, B2M, TNF
48nitric oxide44 11 248.7TNF, TNFRSF1A, TNFRSF1B, TNFRSF10A, TNFSF10, LTA
49retinoic acid44 247.3TKT, TNF, TNFRSF1B, TNFRSF1A, IL6, IL1A
50vegf446.2TKT, B2M, TNFRSF1B, TNFRSF1A, TNFSF10, TNF

GO Terms for genes affiliated with Post-Transplant Lymphoproliferative Disease

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Sources:
16Gene Ontology
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Cellular components related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phagocytic vesicle membraneGO:0306709.2HLA-A, B2M, SLC11A1
2MHC class I protein complexGO:0426129.2B2M, HLA-A
3membrane raftGO:0451219.0TNF, TNFRSF1A, TNFRSF1B
4integral to plasma membraneGO:0058877.8TNFRSF1A, TNFSF10, TNF, HLA-A, IL1R1, SLC11A1
5extracellular regionGO:0055767.0TNFRSF1B, TNFRSF1A, TNFSF10, TNF, B2M, IL1R1
6extracellular spaceGO:0056157.0IL6, TNFRSF1A, TNFSF10, TNF, B2M, LTA

Biological processes related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cytokine secretion involved in immune responseGO:00274010.4IL10
2response to molecule of bacterial originGO:0022379.8IL10, B2M
3positive regulation of chronic inflammatory response to antigenic stimulusGO:0028769.7LTA, TNF
4positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.7LTA, TNF
5positive regulation of protein import into nucleus, translocationGO:0331609.7IL6, TNFRSF1A
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.7B2M, HLA-A
7cellular response to estradiol stimulusGO:0713929.6TNFRSF1A, IL10
8defense response to bacteriumGO:0427429.6TNFRSF1A, IL10, SLC11A1
9defense response to protozoanGO:0428329.6SLC11A1, IL6
10receptor biosynthetic processGO:0328009.6TNF, IL10
11positive regulation of interferon-gamma productionGO:0327299.5SLC11A1, LTA, TNF
12extrinsic apoptotic signaling pathway via death domain receptorsGO:0086259.5TNFRSF10A, TNFRSF1A, TNF
13positive regulation of membrane protein ectodomain proteolysisGO:0510449.4TNF, TNFRSF1B
14response to lipopolysaccharideGO:0324969.4TNFRSF1A, LTA, IL6, SLC11A1
15negative regulation of growth of symbiont in hostGO:0441309.4TNF, LTA, IL10
16negative regulation of interleukin-6 productionGO:0327159.3IL10, TNF, TNFRSF1A
17negative regulation of lipid storageGO:0108889.3IL6, TNF
18epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.3IL6, TNF
19activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.3TNFRSF10A, TNFSF10, TNF
20positive regulation of cytokine secretionGO:0507159.2IL1A, IL10, TNF
21defense response to Gram-positive bacteriumGO:0508309.1TNF, LTA, IL6
22humoral immune responseGO:0069599.1IL6, LTA, TNF
23immune responseGO:0069559.0TNFRSF1B, TNFSF10, HLA-A, IL1R1, IL1A
24apoptotic signaling pathwayGO:0971909.0TNF, TNFSF10, TNFRSF1A
25response to glucocorticoid stimulusGO:0513848.9TNF, IL10, IL6
26positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9IL6, IL10, TNF
27positive regulation of chemokine productionGO:0327228.7IL6, TNF
28positive regulation of apoptotic processGO:0430658.7TNFSF10, TNF, LTA, IL6
29cytokine-mediated signaling pathwayGO:0192218.6IL6, IL1A, B2M, HLA-A, TNFRSF1A
30apoptotic processGO:0069158.5TNFRSF10A, TNFRSF1A, TNFSF10, TNF, LTA, IL1A
31response to drugGO:0424938.3TNF, B2M, LTA, IL10, IL6
32positive regulation of transcription from RNA polymerase II promoterGO:0459448.0TNFRSF1A, TNF, IL10, IL1A, IL6, SLC11A1
33inflammatory responseGO:0069547.8SLC11A1, TNFRSF1B, TNFRSF1A, TNF, IL10, IL1A

Molecular functions related to Post-Transplant Lymphoproliferative Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:0050319.9TNFRSF1A, TNFRSF1B
2tumor necrosis factor receptor bindingGO:0051648.9TNFSF10, TNF, LTA
3protease bindingGO:0020208.8IL1R1, TNF, TNFRSF1A
4cytokine activityGO:0051257.6IL6, IL1A, IL10, LTA, TNF, TNFSF10

Products for genes affiliated with Post-Transplant Lymphoproliferative Disease

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  • Antibodies
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Sources for Post-Transplant Lymphoproliferative Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet