PTSD
MCID: PST028
MIFTS: 61

Post-Traumatic Stress Disorder (PTSD) malady

Neuronal category

Summaries for Post-Traumatic Stress Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Post-traumatic stress disorder (ptsd) is a real illness. you can get ptsd after living through or seeing a traumatic event, such as war, a hurricane, sexual assault, physical abuse, or a bad accident. ptsd makes you feel stressed and afraid after the danger is over. it affects your life and the people around you. ptsd can cause problems like flashbacks, or feeling like the event is happening again trouble sleeping or nightmares feeling alone angry outbursts feeling worried, guilty, or sad ptsd starts at different times for different people. signs of ptsd may start soon after a frightening event and then continue. other people develop new or more severe signs months or even years later. ptsd can happen to anyone, even children. treatment may include talk therapy, medicines, or both. treatment might take 6 to 12 weeks. for some people, it takes longer. nih: national institute of mental health

MalaCards: Post-Traumatic Stress Disorder, also known as traumatic neurosis, is related to anxiety disorder and panic disorder. An important gene associated with Post-Traumatic Stress Disorder is CRH (corticotropin releasing hormone), and among its related pathways are superoxide radicals degradation and Oxidative Stress Regulatory Pathway (Erythrocyte). The drugs carbamazepine and lithium and the compounds sulpiride and topiramate have been mentioned in the context of this disorder. Affiliated tissues include liver, spinal cord and brain, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Disease Ontology:8 An anxiety disorder which results from a traumatic experience that results in psychological trauma.

Wikipedia:64 Posttraumatic stress disorder[note 1] (PTSD) is a severe condition that may develop after a person is... more...

Aliases & Classifications for Post-Traumatic Stress Disorder

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 61UMLS, 39NCBI Bookshelf, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

post-traumatic stress disorder 8 10 34 61
traumatic neurosis 8
ptsd 39


External Ids:

Disease Ontology8 DOID:2055
NCIt40 C3389
MeSH35 D013313
ICD9CM27 309.81
ICD1025 F43.1

Related Diseases for Post-Traumatic Stress Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Post-Traumatic Stress Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder31.1BDNF, NPY, DRD2, CRH, MAOA, CNR1
2panic disorder30.8MAOA, CRH
3borderline personality disorder30.8MAOA
4alcohol dependence30.7NPY, DRD2, CRH, MAOA, CNR1
5heroin dependence30.5DRD2
6cocaine dependence30.5DBH, DRD2
7generalized anxiety disorder30.5MAOA
8attention deficit hyperactivity disorder30.5BDNF, DRD2, MAOA, DBH
9substance dependence30.3CNR1, DRD2
10coronary heart disease30.3NR3C1, NPY
11substance abuse30.3DRD2, CRH, CNR1
12asthma30.3ADCYAP1, CNR1, NR3C1
13chronic fatigue syndrome30.3ADCYAP1, MAOA, NR3C1, CRH
14drug addiction30.3CRH, DRD2, BDNF
15social phobia30.3MAOA, DRD2
16autistic disorder30.3ADCYAP1, DBH, GABRB3, BDNF
17atherosclerosis30.3CNR1, SOD1, CAT
18bipolar disorder30.3CRH, PREP, NR3C1, MAOA, DBH, CNR1
19alcohol abuse30.2DRD2
20conduct disorder30.2DRD2, MAOA, DBH
21cocaine abuse30.1DRD2, DBH
22schizoaffective disorder30.1DRD2, BDNF
23nicotine dependence29.8DRD2
24osteoarthritis29.8NR3C1, NPY
25antisocial personality disorder29.8MAOA, DRD2
26combat disorder10.9
27acute stress disorder10.9
28traumatic brain injury10.8
29brain injury10.8
30sleep disorder10.7
31pain disorder10.6
32major depressive disorder10.5
33alexithymia10.5
34n syndrome10.5
35insomnia10.5
36somatization disorder10.4
37adjustment disorder10.4
38post-traumatic epilepsy10.4
39chronic pain10.4
40memory impairment10.4
41acute liver failure10.2
42paranoid schizophrenia10.2
43q fever10.2
44neurotic disorder10.2
45crimean-congo hemorrhagic fever10.2
46trichotillomania10.2
47agoraphobia10.2
48separation anxiety disorder10.2
49morbid obesity10.2
50stiff-person syndrome10.2

Graphical network of the top 20 diseases related to Post-Traumatic Stress Disorder:



Diseases related to post-traumatic stress disorder

Clinical Features for Post-Traumatic Stress Disorder

Drugs & Therapeutics for Post-Traumatic Stress Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Post-Traumatic Stress Disorder

Drug clinical trials:

Search ClinicalTrials for Post-Traumatic Stress Disorder

Search NIH Clinical Center for Post-Traumatic Stress Disorder

Search CenterWatch for Post-Traumatic Stress Disorder

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Post-Traumatic Stress Disorder

Anatomical Context for Post-Traumatic Stress Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Post-Traumatic Stress Disorder:

33
Liver, Spinal cord, Brain, Lung, Whole blood, Cortex, Heart, Salivary gland, Adrenal gland, Breast, Monocytes, Prefrontal cortex, Cingulate cortex, Temporal lobe, Occipital lobe, Amygdala, Pons, Adrenal cortex, Pituitary

Animal Models for Post-Traumatic Stress Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Post-Traumatic Stress Disorder

Sources:
51PubMed
See all sources

Articles related to Post-Traumatic Stress Disorder:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Case Report and Theoretical Description of Accelerated Resolution Therapy (ART) for Military-Related Post-Traumatic Stress Disorder. (24402982)
2014
2
Evidence-based treatment of post-traumatic stress disorder. (24422573)
2014
3
Post-traumatic Stress Disorder Symptoms Mediate the Relationship Between Trauma Exposure and Smoking Status in College Students. (24424717)
2014
4
Association of DHEA, DHEAS, and cortisol with childhood trauma exposure and post-traumatic stress disorder. (23907073)
2014
5
Psychosocial and psychological factors associated with post-traumatic stress disorder following traumatic brain injury in adult civilian populations: A systematic review. (24328796)
2014
6
Childhood maltreatment and post-traumatic stress disorder among incarcerated young offenders. (23978574)
2013
7
Effectiveness of eye movement desensitization and reprocessing treatment in post-traumatic stress disorder after childbirth: a randomized controlled trial protocol. (23550534)
2013
8
Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model. (24130763)
2013
9
Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder. (23667516)
2013
10
Drug use disorders and post-traumatic stress disorder over 25 adult years: role of psychopathology in relational networks. (23726975)
2013
11
Post-traumatic stress disorder among asylum seekers and refugees in Istanbul may be predicted by torture and loss due to violence. (23249303)
2013
12
Persistent fear of aftershocks, impairment of working memory, and acute stress disorder predict post-traumatic stress disorder: 6-month follow-up of help seekers following the L'Aquila earthquake. (24324929)
2013
13
Post traumatic stress disorder and resilience in veterans who served in the South African border war. (24173633)
2013
14
Effects of cortisol on memory in women with borderline personality disorder: role of co-morbid post-traumatic stress disorder and major depression. (23171911)
2013
15
Post-traumatic stress disorder: a neglected health concern among commercial motor vehicle drivers. (24141867)
2013
16
Military sexual trauma increases risk of post-traumatic stress disorder and depression thereby amplifying the possibility of suicidal ideation and cardiovascular disease. (23707816)
2013
17
Post-traumatic stress disorder symptoms after acute lung injury: a 2-year prospective longitudinal study. (23438256)
2013
18
Core modular blood and brain biomarkers in social defeat mouse model for post traumatic stress disorder. (23962043)
2013
19
Alterations in the cortical thickness and the amplitude of low-frequency fluctuation in patients with post-traumatic stress disorder. (23122880)
2013
20
More vulnerability of left than right hippocampal damage in right-handed patients with post-traumatic stress disorder. (23149034)
2013
21
Post-traumatic stress disorder symptoms form a traumatic and non-traumatic stress response dimension. (23539639)
2013
22
Post-traumatic stress disorder in DSM-5: estimates of prevalence and criteria comparison versus DSM-IV-TR in a non-clinical sample of earthquake survivors. (24135508)
2013
23
Post-traumatic stress disorder in partners of people with epilepsy. (23375389)
2013
24
Augmenting cognitive behaviour therapy for post-traumatic stress disorder with emotion tolerance training: a randomized controlled trial. (23406821)
2013
25
Post-traumatic Stress Disorder: An Important Concern in Post-tsunami Crisis. (23833359)
2013
26
Prospective effects of traumatic event re-exposure and post-traumatic stress disorder in syringe exchange participants. (22775291)
2013
27
Minimal clinically important differences for the EQ-5D and QWB-SA in Post-traumatic Stress Disorder (PTSD): results from a Doubly Randomized Preference Trial (DRPT). (23587015)
2013
28
Web-based post-traumatic stress disorder education for military family members. (22479915)
2012
29
Impact of coping styles on post-traumatic stress disorder and depressive symptoms among pregnant women exposed to Hurricane Katrina. (23140063)
2012
30
Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder. (22365651)
2012
31
Discrepancy in diagnosis and treatment of post-traumatic stress disorder (PTSD): treatment for the wrong reason. (22076315)
2012
32
Treating post-traumatic stress disorder-related dreams: what are the options? (23234387)
2012
33
Trauma, psychosis, post-traumatic stress disorder and the application of EMDR. (22622277)
2012
34
Pharmacotherapy for Post-traumatic Stress Disorder In Combat Veterans: Focus on Antidepressants and Atypical Antipsychotic Agents. (22346334)
2012
35
Psychological therapies for the treatment of post-traumatic stress disorder in children and adolescents. (23235632)
2012
36
Altered emotional interference processing in the amygdala and insula in women with Post-Traumatic Stress Disorder. (24179757)
2012
37
Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder. (21981145)
2012
38
Post-traumatic stress disorder, depression and suicidality in inpatients with substance use disorders. (21521385)
2012
39
Early altered resting-state functional connectivity predicts the severity of post-traumatic stress disorder symptoms in acutely traumatized subjects. (23056477)
2012
40
Online self-administered training for post-traumatic stress disorder treatment providers: design and methods for a randomized, prospective intervention study. (22583520)
2012
41
K-complexes are not preferentially evoked to combat sounds in combat-exposed Vietnam veterans with and without post-traumatic stress disorder. (22226900)
2012
42
Development and testing of virtual reality exposure therapy for post-traumatic stress disorder in active duty service members who served in Iraq and Afghanistan. (22730837)
2012
43
Post-traumatic stress disorder, associated medical illnesses, and suicidal behavior: plenty of room for new research. (22609628)
2012
44
Post-traumatic stress disorder (PTSD) in cardiology and oncology--which diagnostic tools should be used? (22656439)
2012
45
How understanding the neurobiology of complex post-traumatic stress disorder can inform clinical practice: a social cognitive and affective neuroscience approach. (21854369)
2011
46
Prospective risk factors for new-onset post-traumatic stress disorder in National Guard soldiers deployed to Iraq. (21144108)
2011
47
Predictive factors of chronic post-traumatic stress disorder 6 months after a road traffic accident. (21094346)
2011
48
New insights into secondary prevention in post-traumatic stress disorder. (22033784)
2011
49
A patient with post-traumatic stress disorder developing stiff person syndrome: is there a correlation? (17558259)
2007
50
From the biology of trauma to secondary preventive pharmalogical measures for post-traumatic stress disorders]. (15959448)
2005

Genetic Variations for Post-Traumatic Stress Disorder

Expression for genes affiliated with Post-Traumatic Stress Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Post-Traumatic Stress Disorder

Search GEO for disease gene expression data for Post-Traumatic Stress Disorder.

Pathways for genes affiliated with Post-Traumatic Stress Disorder

Sources:
38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 30KEGG
See all sources

Compounds for genes affiliated with Post-Traumatic Stress Disorder

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1sulpiride45 29 1111.9CRH, DRD2, NPY
2topiramate45 11 2411.8CNR1, CRH, NPY
3dopac459.8DBH, MAOA, BDNF
4citalopram50 45 11 2412.8BDNF, FKBP5, MAOA
5oleamide45 29 2411.8MAOA, CNR1, FAAH
6homovanillic acid45 2410.7CRH, BDNF, DBH, MAOA
7maoa459.7DRD2, DBH, BDNF, MAOA
8amphetamine45 1110.7NPY, CNR1, DRD2, MAOA
9nmda45 2910.6BDNF, MAOA, CNR1, ADCYAP1
10semiquinone459.6MAOA, CAT, SOD1
11pacap 38459.6ADCYAP1, NPY, ADCYAP1R1
12morphine45 50 29 1112.6DRD2, CNR1, DBH, ADCYAP1, NR3C1
13opiate459.6NPY, DBH, CRH, DRD2, NR3C1
14mptp459.6DBH, BDNF, DRD2, MAOA
15rasagiline45 1110.6BDNF, CAT, MAOA
16imipramine45 50 29 11 2413.5BDNF, DBH, MAOA, NR3C1
17glutamate459.5MAOA, NPY, PREP, DRD2
18mhpg459.5BDNF, NPY, CRH, MAOA, DBH
19desipramine45 50 1111.5CNR1, MAOA, NR3C1, CRH, BDNF
20cycloheximide459.5CAT, FKBP5
21fluoxetine50 45 29 1112.5MAOA, CRH, BDNF, DRD2, CNR1
22tetrodotoxin45 60 2911.5ADCYAP1, BDNF, NPY, CRH, CNR1
23gnrh459.4PREP, DBH, BDNF, ADCYAP1
24capsaicin45 2910.4CRH, MAOA, CNR1, BDNF, NPY
25benzyl alcohol45 1110.4CAT, SOD1, MAOA
26selegiline45 1110.3MAOA, SOD1, BDNF, CAT
27haloperidol45 29 2 50 1113.3NPY, BDNF, DRD2, ADCYAP1
28catecholamine459.2ADCYAP1, DBH, MAOA, CRH, NPY, BDNF
29carbachol45 29 1111.2NR3C1, CRH, ADCYAP1, CNR1, BDNF, NPY
30acth459.2ADCYAP1, NR3C1, CRH, NPY, BDNF, DBH
315-hydroxytryptamine459.2ADCYAP1, CNR1, DBH, CRH, DRD2, NPY
32nicotine45 50 29 1112.1CNR1, NPY, ADCYAP1, DRD2, CRH, MAOA
33methamphetamine45 50 1111.1BDNF, NPY, FAAH, DRD2, MAOA
34corticosterone45 60 2411.1NR3C1, DBH, CNR1, BDNF, CRH, ADCYAP1
35cocaine45 1110.0CNR1, DBH, CRH, DRD2, NPY, BDNF
36histamine45 29 2411.0DBH, NPY, BDNF, MAOA, CNR1, CRH
37epinephrine45 11 2411.0ADCYAP1, DBH, BDNF, CRH, NPY, DRD2
38ascorbic acid45 249.8CAT, SOD1, BDNF, DBH, MAOA, DRD2
39testosterone45 60 11 2411.8NPY, CRH, MAOA, NR3C1, BDNF, FKBP5
40acetylcholine45 50 29 11 2412.8ADCYAP1, CNR1, DBH, NR3C1, CRH, DRD2
41cyclic amp45 249.8ADCYAP1, NPY, BDNF, CNR1, DBH, CRH
42norepinephrine45 11 2410.7DBH, CNR1, ADCYAP1, MAOA, CRH, DRD2
43levodopa45 119.7MAOA, CAT, DBH, CNR1, SOD1, BDNF
44lactate458.7SOD1, BDNF, NPY, NR3C1, CAT, DBH
456-hydroxydopamine458.6MAOA, CAT, DRD2, SOD1, BDNF, NPY
46dopamine45 29 11 2411.5NPY, ADCYAP1, BDNF, DBH, MAOA, NR3C1
47adenylate458.4NPY, BDNF, DBH, CNR1, ADCYAP1, DRD2
48indomethacin45 60 29 1111.2SOD1, ADCYAP1, CNR1, CRH, FAAH, NPY
49gaba458.2CRH, GABRB3, MAOA, DBH, CNR1, ADCYAP1
50alanine458.1PREP, CRH, FAAH, NPY, SOD1, DBH

GO Terms for genes affiliated with Post-Traumatic Stress Disorder

Sources:
16Gene Ontology
See all sources

Biological processes related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.2MAOA, DBH
2behavioral response to ethanolGO:04814910.1DBH, DRD2
3positive regulation of growth hormone secretionGO:06012410.1DRD2, ADCYAP1
4response to painGO:04826510.0CRH, DBH
5regulation of synaptic transmission, GABAergicGO:03222810.0CNR1, DRD2
6negative regulation of blood pressureGO:04577610.0CNR1, DRD2, CRH
7synaptic transmission, dopaminergicGO:0019639.9DRD2, CRH
8behaviorGO:0076109.9NPY, MAOA, CNR1
9response to amphetamineGO:0019759.8DBH, DRD2, SOD1
10locomotory behaviorGO:0076269.7SOD1, DBH, DRD2
11feeding behaviorGO:0076319.6BDNF, NPY, DRD2, CRH
12response to hyperoxiaGO:0550939.4CAT, BDNF
13synaptic transmissionGO:0072689.3NPY, GABRB3, CRH, MAOA, DBH
14response to ethanolGO:0454719.0ADCYAP1R1, CRH, SOD1, CNR1, ADCYAP1
15response to drugGO:0424938.9SOD1, DRD2, CRH, ADCYAP1R1

Molecular functions related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4ADCYAP1, CRH, NPY
2receptor bindingGO:0051029.4ADCYAP1, CRH, NPY, CAT

Products for genes affiliated with Post-Traumatic Stress Disorder

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Sources for Post-Traumatic Stress Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet