PTSD
MCID: PST028
MIFTS: 68

Post-Traumatic Stress Disorder (PTSD) malady

Mental diseases, Neuronal diseases categories
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Summaries for Post-Traumatic Stress Disorder

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MedlinePlus:33 Post-traumatic stress disorder (ptsd) is a real illness. you can get ptsd after living through or seeing a traumatic event, such as war, a hurricane, sexual assault, physical abuse, or a bad accident. ptsd makes you feel stressed and afraid after the danger is over. it affects your life and the people around you. ptsd can cause problems like flashbacks, or feeling like the event is happening again trouble sleeping or nightmares feeling alone angry outbursts feeling worried, guilty, or sad ptsd starts at different times for different people. signs of ptsd may start soon after a frightening event and then continue. other people develop new or more severe signs months or even years later. ptsd can happen to anyone, even children. treatment may include talk therapy, medicines, or both. treatment might take 6 to 12 weeks. for some people, it takes longer. nih: national institute of mental health

MalaCards based summary: Post-Traumatic Stress Disorder, also known as traumatic neurosis, is related to panic disorder and borderline personality disorder. An important gene associated with Post-Traumatic Stress Disorder is CRH (corticotropin releasing hormone), and among its related pathways are Biogenic Amine Synthesis and Tyrosine metabolism p.1 dopamine . The drugs carbamazepine and lithium and the compounds mirtazapine and clomipramine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye, and related mouse phenotypes are taste/olfaction and digestive/alimentary.

Disease Ontology:8 An anxiety disorder which results from a traumatic experience that results in psychological trauma.

Wikipedia:65 Posttraumatic stress disorder[note 1] (PTSD) may develop after a person is exposed to one or more... more...

Aliases & Classifications for Post-Traumatic Stress Disorder

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Post-Traumatic Stress Disorder, Aliases & Descriptions:

Name: Post-Traumatic Stress Disorder 8 10 33 62
Traumatic Neurosis 8
 
Ptsd 38


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


External Ids:

Disease Ontology8 DOID:2055
ICD9CM27 309.81
MeSH34 D013313
NCIt39 C3389
ICD1025 F43.1

Related Diseases for Post-Traumatic Stress Disorder

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Diseases related to Post-Traumatic Stress Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1panic disorder31.2SLC6A4, CRH
2borderline personality disorder31.1SLC6A4, MAOA
3personality disorder31.0SLC6A4, DRD2, MAOA
4cocaine dependence31.0DRD2, SLC6A4, DBH
5generalized anxiety disorder31.0SLC6A4, MAOA
6pathological gambling31.0DRD2
7anxiety disorder30.9CRH, MAOA, SLC6A4, BDNF
8bipolar disorder30.8DRD2, SLC6A4
9substance dependence30.7SLC6A4, CNR1, DRD2
10drug dependence30.6SLC6A4, MAOA, CNR1, DRD2
11migraine30.6DBH, SLC6A4, ADCYAP1, DRD2, MAOA, CNR1
12alcohol abuse30.5DRD2, SLC6A4
13substance abuse30.5DRD2, SLC6A4, CRH, CNR1
14autistic disorder30.5SLC6A4, GABRB3, BDNF
15alcohol dependence30.5DRD2, CRH, CNR1, NPY, SLC6A4, MAOA
16social phobia30.5DRD2, MAOA, SLC6A4
17asthma30.5ADCYAP1, CNR1, NR3C1
18attention deficit hyperactivity disorder30.5BDNF, SLC6A4, DBH, MAOA, DRD2
19psychotic disorder30.4DBH, CNR1, MAOA, DRD2, SLC6A4, BDNF
20drug addiction30.4DRD2, BDNF, CRH
21schizoaffective disorder30.4BDNF, DRD2, SLC6A4
22conduct disorder30.4DRD2, MAOA, DBH, SLC6A4
23chronic fatigue syndrome30.3ADCYAP1, NR3C1, SLC6A4, CRH, MAOA
24cocaine abuse30.2SLC6A4, DRD2, DBH
25obesity30.2NPY, MAOA, CNR1, DRD2, FAAH, CRH
26multiple sclerosis30.2FAAH, CNR1, DRD2, ADCYAP1, NPY, BDNF
27antisocial personality disorder30.1MAOA, SLC6A4, DRD2
28dementia30.1BDNF, MAOA, NR3C1
29schizophrenia29.5BDNF, SLC6A4, NPY, NR3C1, DRD2, MAOA
30mood disorder29.4CRH, DRD2, NR3C1, BDNF, CNR1, SLC6A4
31brain injury10.8
32traumatic brain injury10.8
33acute stress disorder10.8
34cerebritis10.5
35breast cancer10.5
36major depressive disorder10.5
37alexithymia10.5
38blindness10.5
39acth-secreting pituitary adenoma10.4CRH, NR3C1
40withdrawal disorder10.4CRH, CNR1
41nelson syndrome10.4NR3C1, CRH
42cushing's syndrome10.4CRH, NR3C1
43melancholia10.4CRH, MAOA
44riley-day syndrome10.4DBH, BDNF
45serotonin syndrome10.4MAOA
46diabetic cataract10.4CAT
47amnestic disorder10.4PREP, CNR1
48burns10.4
49adjustment disorder10.4
50somatization disorder10.4

Graphical network of the top 20 diseases related to Post-Traumatic Stress Disorder:



Diseases related to post-traumatic stress disorder

Symptoms for Post-Traumatic Stress Disorder

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Drugs & Therapeutics for Post-Traumatic Stress Disorder

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Drug clinical trials:

Search ClinicalTrials for Post-Traumatic Stress Disorder

Search NIH Clinical Center for Post-Traumatic Stress Disorder

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Post-Traumatic Stress Disorder

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Anatomical Context for Post-Traumatic Stress Disorder

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MalaCards organs/tissues related to Post-Traumatic Stress Disorder:

32
Brain, Heart, Eye, Cortex, Prefrontal cortex, Breast, Testes, Amygdala, Pituitary, Lung, Spinal cord, Liver, Adrenal gland, Monocytes, Cingulate cortex, Occipital lobe, Pons

Animal Models for Post-Traumatic Stress Disorder or affiliated genes

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Publications for Post-Traumatic Stress Disorder

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Articles related to Post-Traumatic Stress Disorder:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Case Report and Theoretical Description of Accelerated Resolution Therapy (ART) for Military-Related Post-Traumatic Stress Disorder. (24402982)
2014
2
Comparison of Memory Function and MMPI-2 Profile between Post-traumatic Stress Disorder and Adjustment Disorder after a Traffic Accident. (24851120)
2014
3
Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis. (25245500)
2014
4
Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder. (25309317)
2014
5
Predicting post-traumatic stress disorder following first onset acute coronary syndrome: Testing a theoretical model. (23398113)
2013
6
An innovative method to deliver treatment of military sexual trauma and post-traumatic stress disorder. (24083914)
2013
7
Mortality rates between treated post-traumatic stress disorder Israeli male veterans compared to non-diagnosed veterans. (24239328)
2013
8
Prevalence, comorbidity and stability of post-traumatic stress disorder and anxiety and depression symptoms after exposure to physical assault: an 8-year prospective longitudinal study. (23130918)
2013
9
Childhood maltreatment and post-traumatic stress disorder among incarcerated young offenders. (23978574)
2013
10
Influence of post-traumatic stress disorder on neuroinflammation and cell proliferation in a rat model of traumatic brain injury. (24349091)
2013
11
Spiritual experiences of war veterans who suffer from combat-related post-traumatic stress disorder: a qualitative study. (22739811)
2013
12
Treadmill exercise alleviates post-traumatic stress disorder-induced impairment of spatial learning memory in rats. (24278894)
2013
13
Post-traumatic stress disorder and coronary heart disease. (23810873)
2013
14
D-Cycloserine Augmentation of Exposure Therapy for Post-Traumatic Stress Disorder: A Pilot Randomized Clinical Trial. (24217129)
2013
15
Attention to threat images in individuals with clinical and subthreshold symptoms of post-traumatic stress disorder. (23845453)
2013
16
Web-based post-traumatic stress disorder education for military family members. (22479915)
2012
17
Modeling cortisol dynamics in the neuro-endocrine axis distinguishes normal, depression, and post-traumatic stress disorder (PTSD) in humans. (22359492)
2012
18
Post-traumatic stress disorder is associated with poor health behaviors: findings from the heart and soul study. (22023435)
2012
19
Relationship between post-traumatic stress disorder and diabetes among 105,180 asylum seekers in the Netherlands. (21953061)
2012
20
Perceptual processing advantages for trauma-related visual cues in post-traumatic stress disorder. (21733208)
2012
21
Evidence of diffuse damage in frontal and occipital cortex in the brain of patients with post-traumatic stress disorder. (21710131)
2012
22
Relationships between impact on employment, working conditions, socio-occupational categories and symptoms of post-traumatic stress disorder after the industrial disaster in Toulouse, France. (22020864)
2012
23
Impact of coping styles on post-traumatic stress disorder and depressive symptoms among pregnant women exposed to Hurricane Katrina. (23140063)
2012
24
Group music therapy for patients with persistent post-traumatic stress disorder--an exploratory randomized controlled trial with mixed methods evaluation. (22903909)
2012
25
Long-lasting effects of maternal separation on an animal model of post-traumatic stress disorder: effects on memory and hippocampal oxidative stress. (22108759)
2012
26
Brief eclectic psychotherapy v. eye movement desensitisation and reprocessing therapy for post-traumatic stress disorder: randomised controlled trial. (22322458)
2012
27
Childhood trauma increases the risk of post-traumatic stress disorder in response to first-episode psychosis. (22247091)
2012
28
Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder. (22365651)
2012
29
Discrepancy in diagnosis and treatment of post-traumatic stress disorder (PTSD): treatment for the wrong reason. (22076315)
2012
30
Neural correlates of recovery from post-traumatic stress disorder: a longitudinal fMRI investigation of memory encoding. (21382385)
2011
31
Validation of the UCLA Child Post traumatic stress disorder-reaction index in Zambia. (21943178)
2011
32
A brief self-guided telehealth intervention for post-traumatic stress disorder in combat veterans: a pilot study. (21636687)
2011
33
Post-traumatic stress disorder symptoms among emergency nurses: their perspective and a 'tailor-made' solution. (21323975)
2011
34
Management of traumatic events: influence of emotion-centered coping strategies on the occurrence of dissociation and post-traumatic stress disorder. (21552315)
2011
35
Post-traumatic Stress Disorder and Cardiovascular Disease. (21792377)
2011
36
Bio-socio-demographic factors associated with post-traumatic stress disorder in a sample of postpartum Brazilian women. (21744050)
2011
37
Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis. (22738160)
2011
38
A randomized controlled effectiveness trial of cognitive behavior therapy for post-traumatic stress disorder in terrorist-affected people in Thailand. (21991280)
2011
39
Post-traumatic stress disorder, child abuse history, birthweight and gestational age: a prospective cohort study. (21790957)
2011
40
Altered amygdala resting-state functional connectivity in post-traumatic stress disorder. (22102841)
2011
41
How understanding the neurobiology of complex post-traumatic stress disorder can inform clinical practice: a social cognitive and affective neuroscience approach. (21854369)
2011
42
Longitudinal study of probable post-traumatic stress disorder in firefighters exposed to the World Trade Center disaster. (20862700)
2010
43
Preventing post traumatic stress disorder: are drugs the answer? (21070102)
2010
44
Acute stress disorder and post-traumatic stress disorder following traumatic amputation. (20306971)
2010
45
Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome. (20881319)
2010
46
Complex post-traumatic stress disorder in patients with somatization disorder. (19085532)
2009
47
Delta sleep response to metyrapone in post-traumatic stress disorder. (12799616)
2003
48
Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele. (12217937)
2002
49
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
50
From the jumping Frenchmen of Maine to post-traumatic stress disorder: the startle response in neuropsychiatry. (1410093)
1992

Variations for Post-Traumatic Stress Disorder

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Expression for genes affiliated with Post-Traumatic Stress Disorder

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Expression patterns in normal tissues for genes affiliated with Post-Traumatic Stress Disorder

Search GEO for disease gene expression data for Post-Traumatic Stress Disorder.

Pathways for genes affiliated with Post-Traumatic Stress Disorder

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Pathways related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
catecholamine biosynthesis37
10.0DBH, MAOA
210.0MAOA, DBH
39.9NPY, DBH
49.8MAOA, SOD1
59.7CAT, SOD1
69.7GABRB3, BDNF, CNR1
7
Show member pathways
9.6ADCYAP1R1, ADCYAP1
8
Show member pathways
9.6BDNF, MAOA, DRD2
9
Show member pathways
Serotonin Transporter Activity37
9.5SLC6A4, MAOA, DBH
109.4ADCYAP1, CRH, ADCYAP1R1
119.4MAOA, CAT, SOD1
12
Show member pathways
9.1CRH, DRD2, BDNF, MAOA, NPY
138.4MAOA, SLC6A4, ADCYAP1R1, BDNF, NR3C1, ADCYAP1
14
Show member pathways
8.1MAOA, ADCYAP1R1, FAAH, CNR1, DRD2, GABRB3
15
Show member pathways
8.0ADCYAP1, ADCYAP1R1, CRH, DRD2, NR3C1, GABRB3

Compounds for genes affiliated with Post-Traumatic Stress Disorder

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Compounds related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 249)
idCompoundScoreTop Affiliating Genes
1mirtazapine44 50 1111.6FKBP5, CRH, NR3C1, SLC6A4
2clomipramine44 50 1111.5SLC6A4, CRH, FKBP5, MAOA
3tetrodotoxin44 61 2811.5CNR1, NPY, BDNF, ADCYAP1, CRH
4heroin44 50 1111.5SLC6A4, BDNF, DRD2, CNR1
5capsaicin44 2810.5CNR1, MAOA, BDNF, NPY, CRH
6homovanillic acid44 2410.5MAOA, SLC6A4, CRH, DBH, BDNF
7morphine44 50 28 1112.4DBH, CNR1, DRD2, NR3C1, ADCYAP1
8maoa449.4DRD2, BDNF, DBH, MAOA, SLC6A4
9citalopram44 50 24 1112.4MAOA, CRH, BDNF, SLC6A4, FKBP5
10selegiline44 1110.3BDNF, CAT, MAOA, SOD1
11olanzapine44 50 28 24 1113.3BDNF, DRD2, SLC6A4, CNR1, FAAH
12carbachol44 28 1111.3CNR1, CRH, NR3C1, NPY, BDNF, ADCYAP1
13imipramine44 28 50 24 1113.3BDNF, NR3C1, MAOA, DBH, SLC6A4
14catecholamine449.3DBH, ADCYAP1, MAOA, CRH, BDNF, NPY
15mptp449.3DRD2, SLC6A4, BDNF, DBH, MAOA
16acth449.3BDNF, NPY, NR3C1, DBH, ADCYAP1, CRH
17clozapine44 28 50 1112.2BDNF, DRD2, CNR1, FAAH, SLC6A4
18bupropion50 44 24 1112.2CNR1, SLC6A4, DRD2, NPY
19amphetamine44 50 1111.2MAOA, NPY, CNR1, DRD2, SLC6A4
20spec-t449.2SLC6A4, DRD2, CRH, CNR1
21paroxetine44 50 28 1112.2FKBP5, MAOA, BDNF, SLC6A4
22desipramine44 50 1111.2CNR1, SLC6A4, CRH, MAOA, NR3C1, BDNF
23mhpg449.2DBH, CRH, NPY, BDNF, SLC6A4, MAOA
24opiate449.1DRD2, DBH, CRH, NPY, SLC6A4, NR3C1
25haloperidol44 50 28 2 1113.1ADCYAP1, BDNF, SLC6A4, FAAH, DRD2, NPY
26histamine44 28 2411.1NPY, CNR1, DBH, ADCYAP1, MAOA, CRH
27methamphetamine44 50 1111.0BDNF, NPY, FAAH, SLC6A4, DRD2, MAOA
28fluoxetine44 50 28 1111.9DRD2, BDNF, SLC6A4, CRH, CNR1, FKBP5
29acetylcholine44 50 28 24 1112.9CRH, CNR1, ADCYAP1, DBH, NR3C1, DRD2
30levodopa44 119.8MAOA, CNR1, CAT, SOD1, DRD2, BDNF
31ascorbic acid44 249.8DRD2, DBH, BDNF, MAOA, SOD1, CAT
32corticosterone44 61 2410.8NR3C1, DBH, ADCYAP1, CNR1, CRH, SLC6A4
33lithium44 50 24 1111.8SLC6A4, PREP, FKBP5, BDNF, DBH
34nmda44 289.7NPY, DRD2, BDNF, SLC6A4, MAOA, CNR1
356-hydroxydopamine448.7DBH, NPY, BDNF, DRD2, CAT, MAOA
36cocaine44 119.7CNR1, CRH, DBH, NR3C1, NPY, BDNF
375-hydroxytryptamine448.7NPY, DBH, ADCYAP1, CNR1, SLC6A4, DRD2
38nicotine44 28 50 1111.7SLC6A4, NPY, DRD2, CRH, MAOA, CNR1
39indomethacin44 28 61 1111.6BDNF, SOD1, ADCYAP1, FAAH, CNR1, CAT
40epinephrine44 24 1110.6ADCYAP1, MAOA, CRH, DBH, NPY, SLC6A4
41testosterone44 61 24 1111.5MAOA, CRH, NR3C1, NPY, BDNF, FKBP5
42adenylate448.5ADCYAP1R1, NPY, DBH, ADCYAP1, BDNF, DRD2
43norepinephrine44 24 1110.4DBH, ADCYAP1, MAOA, CRH, DRD2, BDNF
44gnrh448.4DBH, SLC6A4, BDNF, NPY, CRH, PREP
45dopamine44 28 24 1111.2DBH, ADCYAP1, CNR1, MAOA, CRH, DRD2
46h2o2447.9DBH, SOD1, ADCYAP1, MAOA, CAT, SLC6A4
47gaba447.9SLC6A4, CNR1, CRH, NR3C1, MAOA, GABRB3
48alanine447.8DBH, SOD1, SLC6A4, FAAH, PREP, CNR1
49cysteine447.5DBH, SOD1, PREP, CNR1, SLC6A4, CRH
50glutamate447.2SLC6A4, SOD1, DBH, NPY, DRD2, CRH

GO Terms for genes affiliated with Post-Traumatic Stress Disorder

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Cellular components related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5BDNF, DBH, SOD1, ADCYAP1, CRH, NPY
2cytoplasmGO:0057377.4SOD1, FKBP5, FAAH, PREP, CRH, NR3C1

Biological processes related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine secretionGO:03360210.3DRD2, CNR1
2dopamine catabolic processGO:04242010.3DBH, MAOA
3response to painGO:04826510.3DBH, CRH
4positive regulation of growth hormone secretionGO:06012410.3DRD2, ADCYAP1
5behavioral response to ethanolGO:04814910.3DBH, DRD2
6synaptic transmission, dopaminergicGO:00196310.3DRD2, CRH
7regulation of synaptic transmission, GABAergicGO:03222810.2CNR1, DRD2
8associative learningGO:00830610.2DRD2, CRH
9negative regulation of blood pressureGO:04577610.1DRD2, CRH, CNR1
10response to morphineGO:04327810.1CNR1, DRD2
11response to hyperoxiaGO:05509310.1CAT, BDNF
12adrenal gland developmentGO:03032510.0CRH, NR3C1
13response to cocaineGO:04222010.0CNR1, DRD2
14response to nicotineGO:03509410.0DRD2, CNR1
15response to amphetamineGO:0019759.9DBH, SOD1, DRD2
16memoryGO:0076139.9SLC6A4, CNR1, DBH
17behavioral fear responseGO:0016629.9BDNF, ADCYAP1
18locomotory behaviorGO:0076269.9DRD2, SOD1, DBH
19cAMP-mediated signalingGO:0199339.8ADCYAP1R1, ADCYAP1
20feeding behaviorGO:0076319.8CRH, DRD2, NPY, BDNF
21negative regulation of neuron apoptotic processGO:0435249.7BDNF, GABRB3, SOD1
22response to axon injuryGO:0486789.5DRD2, SOD1
23synaptic transmissionGO:0072689.5NPY, GABRB3, CRH, MAOA, DBH
24response to hypoxiaGO:0016669.4CAT, DRD2, BDNF, SLC6A4
25response to ethanolGO:0454719.2CRH, CNR1, ADCYAP1R1, ADCYAP1, SOD1
26response to drugGO:0424938.9SOD1, ADCYAP1R1, CRH, DRD2, SLC6A4

Molecular functions related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4NPY, CRH, ADCYAP1
2receptor bindingGO:0051029.3NPY, CRH, CAT, ADCYAP1

Products for genes affiliated with Post-Traumatic Stress Disorder

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Sources for Post-Traumatic Stress Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet