PTSD
MCID: PST028
MIFTS: 64

Post-Traumatic Stress Disorder (PTSD) malady

Neuronal diseases category

Summaries for Post-Traumatic Stress Disorder

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Post-traumatic stress disorder (ptsd) is a real illness. you can get ptsd after living through or seeing a traumatic event, such as war, a hurricane, sexual assault, physical abuse, or a bad accident. ptsd makes you feel stressed and afraid after the danger is over. it affects your life and the people around you. ptsd can cause problems like flashbacks, or feeling like the event is happening again trouble sleeping or nightmares feeling alone angry outbursts feeling worried, guilty, or sad ptsd starts at different times for different people. signs of ptsd may start soon after a frightening event and then continue. other people develop new or more severe signs months or even years later. ptsd can happen to anyone, even children. treatment may include talk therapy, medicines, or both. treatment might take 6 to 12 weeks. for some people, it takes longer. nih: national institute of mental health

MalaCards: Post-Traumatic Stress Disorder, also known as traumatic neurosis, is related to anxiety disorder and personality disorder. An important gene associated with Post-Traumatic Stress Disorder is CRH (corticotropin releasing hormone), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and superoxide radicals degradation. The drugs carbamazepine and lithium and the compounds sulpiride and topiramate have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Disease Ontology:8 An anxiety disorder which results from a traumatic experience that results in psychological trauma.

Wikipedia:63 Posttraumatic stress disorder[note 1] (PTSD) may develop after a person is exposed to one or more... more...

Aliases & Classifications for Post-Traumatic Stress Disorder

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 38NCBI Bookshelf, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

post-traumatic stress disorder 8 10 33 60
traumatic neurosis 8
ptsd 38


External Ids:

Disease Ontology8 DOID:2055
NCIt39 C3389
MeSH34 D013313
ICD9CM27 309.81
ICD1025 F43.1

Related Diseases for Post-Traumatic Stress Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Post-Traumatic Stress Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder31.0BDNF, NPY, DRD2, CRH, MAOA, CNR1
2personality disorder30.9DRD2, MAOA
3psychotic disorder30.8BDNF, DRD2, MAOA, DBH, CNR1
4alcohol dependence30.8NPY, DRD2, CRH, MAOA, CNR1
5borderline personality disorder30.7MAOA
6migraine30.7DRD2, MAOA, DBH, CNR1, ADCYAP1
7mood disorder30.7NR3C1, MAOA, DBH, CNR1, CRH, DRD2
8schizophrenia30.7BDNF, NPY, FAAH, DRD2, PREP, NR3C1
9cocaine dependence30.6DBH, DRD2
10panic disorder30.6MAOA, CRH
11breast cancer30.6FAAH, DRD2, NR3C1, CNR1, ADCYAP1
12heroin dependence30.5DRD2
13generalized anxiety disorder30.5MAOA
14drug dependence30.5DRD2, MAOA, CNR1
15attention deficit hyperactivity disorder30.5BDNF, DRD2, MAOA, DBH
16obesity30.5NPY, FAAH, DRD2, CRH, NR3C1, MAOA
17substance dependence30.3CNR1, DRD2
18substance abuse30.3DRD2, CRH, CNR1
19social phobia30.3MAOA, DRD2
20asthma30.3ADCYAP1, CNR1, NR3C1
21chronic fatigue syndrome30.2ADCYAP1, MAOA, NR3C1, CRH
22dementia30.2MAOA, NR3C1, BDNF
23autistic disorder30.2ADCYAP1, DBH, GABRB3, BDNF
24atherosclerosis30.2CNR1, SOD1, CAT
25bipolar disorder30.2BDNF, NPY, CRH, NR3C1, MAOA
26multiple sclerosis30.2BDNF, NPY, FAAH, DRD2, CNR1, ADCYAP1
27alcohol abuse30.2DRD2
28conduct disorder30.2DRD2, MAOA, DBH
29cocaine abuse30.0DRD2, DBH
30schizoaffective disorder30.0DRD2, BDNF
31nicotine dependence29.8DRD2
32osteoarthritis29.8NR3C1, NPY
33antisocial personality disorder29.8MAOA, DRD2
34combat disorder10.9
35acute stress disorder10.9
36sleep disorder10.7
37dissociative disorder10.6
38sexual disorder10.6
39pain disorder10.6
40major depressive disorder10.5
41physical disorder10.5
42cerebritis10.5
43somatization disorder10.4
44alexithymia10.4
45adjustment disorder10.3
46neuronitis10.3
47acute liver failure10.2
48burns10.2
49paranoid schizophrenia10.2
50crimean-congo hemorrhagic fever10.2

Graphical network of the top 20 diseases related to Post-Traumatic Stress Disorder:



Diseases related to post-traumatic stress disorder

Clinical Features for Post-Traumatic Stress Disorder

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Drugs & Therapeutics for Post-Traumatic Stress Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Post-Traumatic Stress Disorder

Drug clinical trials:

Search ClinicalTrials for Post-Traumatic Stress Disorder

Search NIH Clinical Center for Post-Traumatic Stress Disorder

Search CenterWatch for Post-Traumatic Stress Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Post-Traumatic Stress Disorder

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Anatomical Context for Post-Traumatic Stress Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Post-Traumatic Stress Disorder:

32
Brain, Heart, Eye, Cortex, Prefrontal cortex, Amygdala, Testes, Breast, Pituitary, Lung, Pons, Spinal cord, Occipital lobe, Temporal lobe, Cingulate cortex, Liver, Monocytes, Adrenal gland

Animal Models for Post-Traumatic Stress Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Post-Traumatic Stress Disorder:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7NPY, DRD2, PREP, NR3C1, CNR1, ADCYAP1
2MP:00053818.7CNR1, NR3C1, GABRB3, DRD2, NPY, BDNF
3MP:00107718.4BDNF, FAAH, DRD2, CRH, NR3C1, DBH
4MP:00053708.3SOD1, NPY, DRD2, PREP, NR3C1, ADCYAP1
5MP:00030128.0BDNF, DRD2, GABRB3, NR3C1, CNR1, ADCYAP1R1
6MP:00028737.5BDNF, NPY, FAAH, GABRB3, CRH, NR3C1
7MP:00053897.4BDNF, SOD1, DRD2, GABRB3, NR3C1, FKBP5
8MP:00053787.0BDNF, NPY, DRD2, GABRB3, CRH, PREP
9MP:00107686.4DRD2, FAAH, SOD1, CAT, BDNF, GABRB3
10MP:00036315.8GABRB3, DRD2, FAAH, NPY, SOD1, BDNF
11MP:00053865.5ADCYAP1R1, BDNF, SOD1, NPY, FAAH, DRD2
12MP:00053765.5DRD2, FAAH, NPY, SOD1, CAT, BDNF

Publications for Post-Traumatic Stress Disorder

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Sources:
50PubMed
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Articles related to Post-Traumatic Stress Disorder:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Off-label use of second generation antipsychotics for post-traumatic stress disorder in the Department of Veterans Affairs: time trends and sociodemographic, comorbidity, and regional correlates. (23996688)
2014
2
Attentional and executive functions are differentially affected by post-traumatic stress disorder and trauma. (24199652)
2014
3
Increased co-morbidity of depression and post-traumatic stress disorder symptoms and common risk factors in intensive care unit survivors: A two-year follow-up study. (24151923)
2014
4
Psychosocial and psychological factors associated with post-traumatic stress disorder following traumatic brain injury in adult civilian populations: A systematic review. (24328796)
2014
5
Post-traumatic stress disorder and coronary heart disease. (23810873)
2013
6
D-Cycloserine Augmentation of Exposure Therapy for Post-Traumatic Stress Disorder: A Pilot Randomized Clinical Trial. (24217129)
2013
7
Post-traumatic stress disorder in trainee doctors with previous needlestick injuries. (23580567)
2013
8
Combat experiences, pre-deployment training, and outcome of exposure therapy for post-traumatic stress disorder in Operation Enduring Freedom/Operation Iraqi Freedom veterans. (22253233)
2013
9
Voluntary exercise does not ameliorate context memory and hyperarousal in a mouse model for post-traumatic stress disorder (PTSD). (21736515)
2013
10
Salivary cortisol and dehydroepiandrosterone sulfate in adolescent rape victims with post traumatic stress disorder. (22867760)
2013
11
A randomized, controlled pilot study of MDMA (A+ 3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD). (23118021)
2013
12
N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder. (24169639)
2013
13
Combat exposure severity as a moderator of genetic and environmental liability to post-traumatic stress disorder. (24001428)
2013
14
Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study. (23172889)
2013
15
Dysfunction and post-traumatic stress disorder in fracture victims 50 months after the sichuan earthquake. (24204861)
2013
16
Regional cerebral changes and functional connectivity during the observation of negative emotional stimuli in subjects with post-traumatic stress disorder. (23385487)
2013
17
Changes in 5-HT1A receptor expression in the oculomotor nucleus in a rat model of post-traumatic stress disorder. (22930314)
2013
18
What kind of diagnosis in a case of mobbing: post-traumatic stress disorder or adjustment disorder? (23761569)
2013
19
Dialectical behaviour therapy for post-traumatic stress disorder after childhood sexual abuse in patients with and without borderline personality disorder: a randomised controlled trial. (23712109)
2013
20
Substance abuse, memory, and post-traumatic stress disorder. (24345414)
2013
21
Perturbed threat monitoring following a traumatic event predicts risk for post-traumatic stress disorder. (24131552)
2013
22
Influence of predispositions on post-traumatic stress disorder: does it vary by trauma severity? (22703614)
2013
23
Examining the nature of the comorbidity between pediatric attention deficit/hyperactivity disorder and post-traumatic stress disorder. (22985097)
2013
24
The sleep effects of tiagabine on the first night of treatment predict post-traumatic stress disorder response at three weeks. (24288237)
2013
25
THE CANON--3: The harmony of illusions: inventing post-traumatic stress disorder, by Allan Young. (22612498)
2012
26
Understanding depression as it occurs in the context of post-traumatic stress disorder. (22852074)
2012
27
ALTERED BLOOD SPHINGOLIPIDOMICS AND ELEVATED PLASMA INFLAMMATORY CYTOKINES IN COMBAT VETERANS WITH POST-TRAUMATIC STRESS DISORDER. (24403911)
2012
28
Post-traumatic stress disorder, associated medical illnesses, and suicidal behavior: plenty of room for new research. (22609628)
2012
29
Post-traumatic stress disorder symptoms in emotionally distressed individuals referred for a depression prevention intervention: relationship to problem-solving skills. (23044651)
2012
30
Validation of the UCLA Child Post traumatic stress disorder-reaction index in Zambia. (21943178)
2011
31
A brief self-guided telehealth intervention for post-traumatic stress disorder in combat veterans: a pilot study. (21636687)
2011
32
Post-traumatic stress disorder symptoms among emergency nurses: their perspective and a 'tailor-made' solution. (21323975)
2011
33
Functional neuroimaging studies of post-traumatic stress disorder. (21306214)
2011
34
Common genetic and environmental contributions to post-traumatic stress disorder and alcohol dependence in young women. (21054919)
2011
35
A randomized, controlled trial of virtual reality-graded exposure therapy for post-traumatic stress disorder in active duty service members with combat-related post-traumatic stress disorder. (21332375)
2011
36
An fMRI study of unconditioned responses in post-traumatic stress disorder. (22738227)
2011
37
Trauma-focused CBT reduces anxiety and post-traumatic stress disorder in children exposed to intimate partner violence. (21502162)
2011
38
What is post-traumatic stress disorder? (22033951)
2011
39
The presence of post-traumatic stress disorder symptoms in adolescents three months after an 8A^0 magnitude earthquake in southwest China. (21883571)
2011
40
Childhood trauma among individuals with co-morbid substance use and post traumatic stress disorder. (21984884)
2011
41
Post-traumatic stress disorder (PTSD) symptoms predict delay to hospital in patients with acute coronary syndrome. (22096608)
2011
42
Acute inescapable stress exposure induces long-term sleep disturbances and avoidance behavior: a mouse model of post-traumatic stress disorder (PTSD). (21377492)
2011
43
Reality graded exposure therapy with physiological monitoring for the treatment of combat related post traumatic stress disorder: a pilot study. (21335883)
2011
44
Intensive care diaries reduce new onset post traumatic stress disorder following critical illness: a randomised, controlled trial. (20843344)
2010
45
Hurricane Katrina experience and the risk of post-traumatic stress disorder and depression among pregnant women. (20701175)
2010
46
Validity of 'post-traumatic stress disorder with secondary psychotic features': a review of the evidence. (18764840)
2009
47
Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder. (19409951)
2009
48
Dopamine beta-hydroxylase (DBH) activity and -1021C/T polymorphism of DBH gene in combat-related post-traumatic stress disorder. (17853400)
2007
49
Post-traumatic stress disorder among people with heroin dependence in the Australian treatment outcome study (ATOS): prevalence and correlates. (15734224)
2005
50
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997

Genetic Variations for Post-Traumatic Stress Disorder

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Expression for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Post-Traumatic Stress Disorder

Search GEO for disease gene expression data for Post-Traumatic Stress Disorder.

Pathways for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 29KEGG
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Compounds for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1sulpiride44 28 1111.9CRH, DRD2, NPY
2topiramate44 11 2411.8CNR1, CRH, NPY
3dopac449.8DBH, MAOA, BDNF
4citalopram49 44 11 2412.8BDNF, FKBP5, MAOA
5oleamide44 28 2411.8MAOA, CNR1, FAAH
6homovanillic acid44 2410.7CRH, BDNF, DBH, MAOA
7maoa449.7DRD2, DBH, BDNF, MAOA
8amphetamine44 1110.7NPY, CNR1, DRD2, MAOA
9nmda44 2810.6BDNF, MAOA, CNR1, ADCYAP1
10semiquinone449.6MAOA, CAT, SOD1
11pacap 38449.6ADCYAP1, NPY, ADCYAP1R1
12morphine44 49 28 1112.6DRD2, CNR1, DBH, ADCYAP1, NR3C1
13opiate449.6NPY, DBH, CRH, DRD2, NR3C1
14mptp449.6DBH, BDNF, DRD2, MAOA
15rasagiline44 1110.6BDNF, CAT, MAOA
16imipramine44 49 28 11 2413.5BDNF, DBH, MAOA, NR3C1
17glutamate449.5MAOA, NPY, PREP, DRD2
18mhpg449.5BDNF, NPY, CRH, MAOA, DBH
19desipramine44 49 1111.5CNR1, MAOA, NR3C1, CRH, BDNF
20cycloheximide449.5CAT, FKBP5
21fluoxetine49 44 28 1112.5MAOA, CRH, BDNF, DRD2, CNR1
22tetrodotoxin44 59 2811.5ADCYAP1, BDNF, NPY, CRH, CNR1
23gnrh449.4PREP, DBH, BDNF, ADCYAP1
24capsaicin44 2810.4CRH, MAOA, CNR1, BDNF, NPY
25benzyl alcohol44 1110.4CAT, SOD1, MAOA
26selegiline44 1110.3MAOA, SOD1, BDNF, CAT
27haloperidol44 28 2 49 1113.3NPY, BDNF, DRD2, ADCYAP1
28catecholamine449.2ADCYAP1, DBH, MAOA, CRH, NPY, BDNF
29carbachol44 28 1111.2NR3C1, CRH, ADCYAP1, CNR1, BDNF, NPY
30acth449.2ADCYAP1, NR3C1, CRH, NPY, BDNF, DBH
315-hydroxytryptamine449.2ADCYAP1, CNR1, DBH, CRH, DRD2, NPY
32nicotine44 49 28 1112.1CNR1, NPY, ADCYAP1, DRD2, CRH, MAOA
33methamphetamine44 49 1111.1BDNF, NPY, FAAH, DRD2, MAOA
34corticosterone44 59 2411.1NR3C1, DBH, CNR1, BDNF, CRH, ADCYAP1
35cocaine44 1110.0CNR1, DBH, CRH, DRD2, NPY, BDNF
36histamine44 28 2411.0DBH, NPY, BDNF, MAOA, CNR1, CRH
37epinephrine44 11 2411.0ADCYAP1, DBH, BDNF, CRH, NPY, DRD2
38ascorbic acid44 249.8CAT, SOD1, BDNF, DBH, MAOA, DRD2
39testosterone44 59 11 2411.8NPY, CRH, MAOA, NR3C1, BDNF, FKBP5
40acetylcholine44 49 28 11 2412.8ADCYAP1, CNR1, DBH, NR3C1, CRH, DRD2
41cyclic amp44 249.8ADCYAP1, NPY, BDNF, CNR1, DBH, CRH
42norepinephrine44 11 2410.7DBH, CNR1, ADCYAP1, MAOA, CRH, DRD2
43levodopa44 119.7MAOA, CAT, DBH, CNR1, SOD1, BDNF
44lactate448.7SOD1, BDNF, NPY, NR3C1, CAT, DBH
456-hydroxydopamine448.6MAOA, CAT, DRD2, SOD1, BDNF, NPY
46dopamine44 28 11 2411.5NPY, ADCYAP1, BDNF, DBH, MAOA, NR3C1
47adenylate448.4NPY, BDNF, DBH, CNR1, ADCYAP1, DRD2
48indomethacin44 59 28 1111.2SOD1, ADCYAP1, CNR1, CRH, FAAH, NPY
49gaba448.2CRH, GABRB3, MAOA, DBH, CNR1, ADCYAP1
50alanine448.1PREP, CRH, FAAH, NPY, SOD1, DBH

GO Terms for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
16Gene Ontology
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Biological processes related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.2DBH, MAOA
2positive regulation of growth hormone secretionGO:06012410.1DRD2, ADCYAP1
3behavioral response to ethanolGO:04814910.1DRD2, DBH
4response to painGO:04826510.0DBH, CRH
5regulation of synaptic transmission, GABAergicGO:03222810.0DRD2, CNR1
6negative regulation of blood pressureGO:04577610.0DRD2, CRH, CNR1
7synaptic transmission, dopaminergicGO:0019639.9CRH, DRD2
8behaviorGO:0076109.9CNR1, MAOA, NPY
9response to amphetamineGO:0019759.8DBH, DRD2, SOD1
10locomotory behaviorGO:0076269.7SOD1, DRD2, DBH
11feeding behaviorGO:0076319.6BDNF, NPY, DRD2, CRH
12response to hyperoxiaGO:0550939.4CAT, BDNF
13synaptic transmissionGO:0072689.3NPY, GABRB3, CRH, MAOA, DBH
14response to ethanolGO:0454719.0ADCYAP1R1, ADCYAP1, CNR1, CRH, SOD1
15response to drugGO:0424938.9SOD1, DRD2, CRH, ADCYAP1R1

Molecular functions related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4ADCYAP1, CRH, NPY
2receptor bindingGO:0051029.4ADCYAP1, CRH, NPY, CAT

Products for genes affiliated with Post-Traumatic Stress Disorder

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Sources for Post-Traumatic Stress Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet