PTSD
MCID: PST028
MIFTS: 67

Post-Traumatic Stress Disorder (PTSD) malady

Mental diseases, Neuronal diseases categories

Summaries for Post-Traumatic Stress Disorder

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Post-traumatic stress disorder (ptsd) is a real illness. you can get ptsd after living through or seeing a traumatic event, such as war, a hurricane, sexual assault, physical abuse, or a bad accident. ptsd makes you feel stressed and afraid after the danger is over. it affects your life and the people around you. ptsd can cause problems like flashbacks, or feeling like the event is happening again trouble sleeping or nightmares feeling alone angry outbursts feeling worried, guilty, or sad ptsd starts at different times for different people. signs of ptsd may start soon after a frightening event and then continue. other people develop new or more severe signs months or even years later. ptsd can happen to anyone, even children. treatment may include talk therapy, medicines, or both. treatment might take 6 to 12 weeks. for some people, it takes longer. nih: national institute of mental health

MalaCards: Post-Traumatic Stress Disorder, also known as traumatic neurosis, is related to borderline personality disorder and personality disorder. An important gene associated with Post-Traumatic Stress Disorder is CRH (corticotropin releasing hormone), and among its related pathways are Biogenic Amine Synthesis and Tyrosine metabolism p.1 dopamine . The drugs carbamazepine and lithium and the compounds mirtazapine and clomipramine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and cortex, and related mouse phenotypes are taste/olfaction and digestive/alimentary.

Disease Ontology:9 An anxiety disorder which results from a traumatic experience that results in psychological trauma.

Wikipedia:66 Posttraumatic stress disorder[note 1] (PTSD) may develop after a person is exposed to one or more... more...

Aliases & Classifications for Post-Traumatic Stress Disorder

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Sources:
9Disease Ontology, 11DISEASES, 35MedlinePlus, 63UMLS, 40NCBI Bookshelf, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases, Neuronal diseases


Aliases & Descriptions:

post-traumatic stress disorder 9 11 35 63
traumatic neurosis 9
ptsd 40


External Ids:

Disease Ontology9 DOID:2055
NCIt41 C3389
ICD9CM28 309.81
MeSH36 D013313
ICD1026 F43.1

Related Diseases for Post-Traumatic Stress Disorder

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Post-Traumatic Stress Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1borderline personality disorder30.9MAOA, SLC6A4
2personality disorder30.8MAOA, DRD2, SLC6A4
3anxiety disorder30.8MAOA, CRH, BDNF, SLC6A4
4panic disorder30.8CRH, SLC6A4
5cocaine dependence30.8SLC6A4, DRD2, DBH
6migraine30.7DBH, ADCYAP1, CNR1, MAOA, DRD2, SLC6A4
7alcohol dependence30.7CNR1, MAOA, CRH, DRD2, NPY, SLC6A4
8generalized anxiety disorder30.7SLC6A4, MAOA
9psychotic disorder30.6DBH, CNR1, MAOA, DRD2, BDNF, SLC6A4
10drug dependence30.6CNR1, MAOA, DRD2, SLC6A4
11attention deficit hyperactivity disorder30.5DBH, MAOA, DRD2, BDNF, SLC6A4
12substance dependence30.5CNR1, DRD2, SLC6A4
13schizophrenia30.5SLC6A4, BDNF, NPY, NR3C1, DRD2, MAOA
14obesity30.5FAAH, CNR1, MAOA, CRH, DRD2, NR3C1
15bipolar disorder30.4SLC6A4, DRD2
16dementia30.4BDNF, NR3C1, MAOA
17substance abuse30.4CNR1, CRH, DRD2, SLC6A4
18autistic disorder30.4SLC6A4, BDNF, GABRB3
19asthma30.4ADCYAP1, CNR1, NR3C1
20chronic fatigue syndrome30.3ADCYAP1, MAOA, CRH, NR3C1, SLC6A4
21alcohol abuse30.3SLC6A4, DRD2
22pathological gambling30.3DRD2
23social phobia30.3MAOA, DRD2, SLC6A4
24multiple sclerosis30.3ADCYAP1, FAAH, CNR1, DRD2, NPY, BDNF
25conduct disorder30.3DBH, MAOA, DRD2, SLC6A4
26schizoaffective disorder30.2DRD2, BDNF, SLC6A4
27mood disorder30.1SLC6A4, BDNF, NPY, NR3C1, DRD2, CRH
28drug addiction30.0CRH, DRD2, BDNF
29cocaine abuse30.0DBH, DRD2, SLC6A4
30antisocial personality disorder29.9SLC6A4, DRD2, MAOA
31brain injury10.8
32traumatic brain injury10.8
33acute stress disorder10.8
34cerebritis10.5
35major depressive disorder10.5
36alexithymia10.5
37breast cancer10.5
38insomnia10.5
39neuronitis10.4
40heroin dependence10.4
41somatization disorder10.4
42aneurysm10.4
43chronic pain10.4
44blindness10.4
45acute liver failure10.2
46burns10.2
47paranoid schizophrenia10.2
48agoraphobia10.2
49adjustment disorder10.2
50morbid obesity10.2

Graphical network of the top 20 diseases related to Post-Traumatic Stress Disorder:



Diseases related to post-traumatic stress disorder

Symptoms for Post-Traumatic Stress Disorder

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Drugs & Therapeutics for Post-Traumatic Stress Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Post-Traumatic Stress Disorder

Drug clinical trials:

Search ClinicalTrials for Post-Traumatic Stress Disorder

Search NIH Clinical Center for Post-Traumatic Stress Disorder

Search CenterWatch for Post-Traumatic Stress Disorder

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Post-Traumatic Stress Disorder

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Anatomical Context for Post-Traumatic Stress Disorder

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Sources:
34MalaCards
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MalaCards organs/tissues related to Post-Traumatic Stress Disorder:

34
Brain, Heart, Cortex, Eye, Prefrontal cortex, Pituitary, Breast, Amygdala, Testes, Lung, Occipital lobe, Cingulate cortex, Liver, Temporal lobe, Adrenal gland, Monocytes, Spinal cord, Pons

Animal Models for Post-Traumatic Stress Disorder or affiliated genes

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Sources:
38MGI
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Publications for Post-Traumatic Stress Disorder

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Sources:
53PubMed
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Articles related to Post-Traumatic Stress Disorder:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
Case Report and Theoretical Description of Accelerated Resolution Therapy (ART) for Military-Related Post-Traumatic Stress Disorder. (24402982)
2014
2
Predicting post-traumatic stress disorder following first onset acute coronary syndrome: Testing a theoretical model. (23398113)
2013
3
An innovative method to deliver treatment of military sexual trauma and post-traumatic stress disorder. (24083914)
2013
4
Mortality rates between treated post-traumatic stress disorder Israeli male veterans compared to non-diagnosed veterans. (24239328)
2013
5
Prevalence, comorbidity and stability of post-traumatic stress disorder and anxiety and depression symptoms after exposure to physical assault: an 8-year prospective longitudinal study. (23130918)
2013
6
Childhood maltreatment and post-traumatic stress disorder among incarcerated young offenders. (23978574)
2013
7
Influence of post-traumatic stress disorder on neuroinflammation and cell proliferation in a rat model of traumatic brain injury. (24349091)
2013
8
Spiritual experiences of war veterans who suffer from combat-related post-traumatic stress disorder: a qualitative study. (22739811)
2013
9
Treadmill exercise alleviates post-traumatic stress disorder-induced impairment of spatial learning memory in rats. (24278894)
2013
10
Post-traumatic stress disorder and coronary heart disease. (23810873)
2013
11
D-Cycloserine Augmentation of Exposure Therapy for Post-Traumatic Stress Disorder: A Pilot Randomized Clinical Trial. (24217129)
2013
12
Attention to threat images in individuals with clinical and subthreshold symptoms of post-traumatic stress disorder. (23845453)
2013
13
Web-based post-traumatic stress disorder education for military family members. (22479915)
2012
14
Modeling cortisol dynamics in the neuro-endocrine axis distinguishes normal, depression, and post-traumatic stress disorder (PTSD) in humans. (22359492)
2012
15
Post-traumatic stress disorder is associated with poor health behaviors: findings from the heart and soul study. (22023435)
2012
16
Relationship between post-traumatic stress disorder and diabetes among 105,180 asylum seekers in the Netherlands. (21953061)
2012
17
Perceptual processing advantages for trauma-related visual cues in post-traumatic stress disorder. (21733208)
2012
18
Evidence of diffuse damage in frontal and occipital cortex in the brain of patients with post-traumatic stress disorder. (21710131)
2012
19
Relationships between impact on employment, working conditions, socio-occupational categories and symptoms of post-traumatic stress disorder after the industrial disaster in Toulouse, France. (22020864)
2012
20
Impact of coping styles on post-traumatic stress disorder and depressive symptoms among pregnant women exposed to Hurricane Katrina. (23140063)
2012
21
Group music therapy for patients with persistent post-traumatic stress disorder--an exploratory randomized controlled trial with mixed methods evaluation. (22903909)
2012
22
Long-lasting effects of maternal separation on an animal model of post-traumatic stress disorder: effects on memory and hippocampal oxidative stress. (22108759)
2012
23
Brief eclectic psychotherapy v. eye movement desensitisation and reprocessing therapy for post-traumatic stress disorder: randomised controlled trial. (22322458)
2012
24
Childhood trauma increases the risk of post-traumatic stress disorder in response to first-episode psychosis. (22247091)
2012
25
Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder. (22365651)
2012
26
Discrepancy in diagnosis and treatment of post-traumatic stress disorder (PTSD): treatment for the wrong reason. (22076315)
2012
27
Treating post-traumatic stress disorder-related dreams: what are the options? (23234387)
2012
28
A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder. (22026588)
2012
29
Neural correlates of recovery from post-traumatic stress disorder: a longitudinal fMRI investigation of memory encoding. (21382385)
2011
30
Validation of the UCLA Child Post traumatic stress disorder-reaction index in Zambia. (21943178)
2011
31
A brief self-guided telehealth intervention for post-traumatic stress disorder in combat veterans: a pilot study. (21636687)
2011
32
Post-traumatic stress disorder symptoms among emergency nurses: their perspective and a 'tailor-made' solution. (21323975)
2011
33
Management of traumatic events: influence of emotion-centered coping strategies on the occurrence of dissociation and post-traumatic stress disorder. (21552315)
2011
34
Post-traumatic Stress Disorder and Cardiovascular Disease. (21792377)
2011
35
Bio-socio-demographic factors associated with post-traumatic stress disorder in a sample of postpartum Brazilian women. (21744050)
2011
36
Event-related potential studies of post-traumatic stress disorder: a critical review and synthesis. (22738160)
2011
37
A randomized controlled effectiveness trial of cognitive behavior therapy for post-traumatic stress disorder in terrorist-affected people in Thailand. (21991280)
2011
38
Post-traumatic stress disorder, child abuse history, birthweight and gestational age: a prospective cohort study. (21790957)
2011
39
Altered amygdala resting-state functional connectivity in post-traumatic stress disorder. (22102841)
2011
40
How understanding the neurobiology of complex post-traumatic stress disorder can inform clinical practice: a social cognitive and affective neuroscience approach. (21854369)
2011
41
Longitudinal study of probable post-traumatic stress disorder in firefighters exposed to the World Trade Center disaster. (20862700)
2010
42
Preventing post traumatic stress disorder: are drugs the answer? (21070102)
2010
43
Acute stress disorder and post-traumatic stress disorder following traumatic amputation. (20306971)
2010
44
Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome. (20881319)
2010
45
Complex post-traumatic stress disorder in patients with somatization disorder. (19085532)
2009
46
Delta sleep response to metyrapone in post-traumatic stress disorder. (12799616)
2003
47
Harmful drinking in military veterans with post-traumatic stress disorder: association with the D2 dopamine receptor A1 allele. (12217937)
2002
48
Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). (9373423)
1997
49
From the jumping Frenchmen of Maine to post-traumatic stress disorder: the startle response in neuropsychiatry. (1410093)
1992
50
Post-traumatic stress disorder masquerading as paranoid schizophrenia: case report. (6817230)
1982

Variations for Post-Traumatic Stress Disorder

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Expression for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Post-Traumatic Stress Disorder

Search GEO for disease gene expression data for Post-Traumatic Stress Disorder.

Pathways for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 52PharmGKB, 31KEGG
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Pathways related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
catecholamine biosynthesis39
10.0MAOA, DBH
210.0DBH, MAOA
39.9NPY, DBH
49.8SOD1, MAOA
59.7SOD1, CAT
69.7BDNF, GABRB3, CNR1
7
Show member pathways
9.6ADCYAP1R1, ADCYAP1
8
Show member pathways
9.6BDNF, DRD2, MAOA
9
Show member pathways
Serotonin Transporter Activity39
9.5DBH, MAOA, SLC6A4
109.4CRH, ADCYAP1R1, ADCYAP1
119.4CAT, MAOA, SOD1
12
Show member pathways
9.1BDNF, NPY, DRD2, CRH, MAOA
138.4SLC6A4, BDNF, NR3C1, MAOA, ADCYAP1R1, ADCYAP1
14
Show member pathways
8.1ADCYAP1R1, FAAH, CNR1, MAOA, DRD2, GABRB3
15
Show member pathways
8.0ADCYAP1, ADCYAP1R1, CNR1, CRH, DRD2, NR3C1

Compounds for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 249)
idCompoundScoreTop Affiliating Genes
1mirtazapine46 52 1211.6FKBP5, CRH, NR3C1, SLC6A4
2clomipramine46 52 1211.5SLC6A4, CRH, FKBP5, MAOA
3tetrodotoxin46 62 3011.5CNR1, NPY, BDNF, ADCYAP1, CRH
4heroin46 52 1211.5SLC6A4, BDNF, DRD2, CNR1
5capsaicin46 3010.5CNR1, MAOA, BDNF, NPY, CRH
6homovanillic acid46 2510.5MAOA, SLC6A4, CRH, DBH, BDNF
7morphine46 52 30 1212.4DBH, CNR1, DRD2, NR3C1, ADCYAP1
8maoa469.4DRD2, BDNF, DBH, MAOA, SLC6A4
9citalopram46 52 25 1212.4MAOA, CRH, BDNF, SLC6A4, FKBP5
10selegiline46 1210.3BDNF, CAT, MAOA, SOD1
11olanzapine46 52 30 25 1213.3BDNF, DRD2, SLC6A4, CNR1, FAAH
12carbachol46 30 1211.3CNR1, CRH, NR3C1, NPY, BDNF, ADCYAP1
13imipramine46 30 52 25 1213.3BDNF, NR3C1, MAOA, DBH, SLC6A4
14catecholamine469.3DBH, ADCYAP1, MAOA, CRH, BDNF, NPY
15mptp469.3DRD2, SLC6A4, BDNF, DBH, MAOA
16acth469.3BDNF, NPY, NR3C1, DBH, ADCYAP1, CRH
17clozapine46 30 52 1212.2BDNF, DRD2, CNR1, FAAH, SLC6A4
18bupropion52 46 25 1212.2CNR1, SLC6A4, DRD2, NPY
19amphetamine46 52 1211.2MAOA, NPY, CNR1, DRD2, SLC6A4
20spec-t469.2SLC6A4, DRD2, CRH, CNR1
21paroxetine46 52 30 1212.2FKBP5, MAOA, BDNF, SLC6A4
22desipramine46 52 1211.2CNR1, SLC6A4, CRH, MAOA, NR3C1, BDNF
23mhpg469.2DBH, CRH, NPY, BDNF, SLC6A4, MAOA
24opiate469.1DRD2, DBH, CRH, NPY, SLC6A4, NR3C1
25haloperidol46 52 30 3 1213.1ADCYAP1, BDNF, SLC6A4, FAAH, DRD2, NPY
26histamine46 30 2511.1NPY, CNR1, DBH, ADCYAP1, MAOA, CRH
27methamphetamine46 52 1211.0BDNF, NPY, FAAH, SLC6A4, DRD2, MAOA
28fluoxetine46 52 30 1211.9DRD2, BDNF, SLC6A4, CRH, CNR1, FKBP5
29acetylcholine46 52 30 25 1212.9CRH, CNR1, ADCYAP1, DBH, NR3C1, DRD2
30levodopa46 129.8MAOA, CNR1, CAT, SOD1, DRD2, BDNF
31ascorbic acid46 259.8DRD2, DBH, BDNF, MAOA, SOD1, CAT
32corticosterone46 62 2510.8NR3C1, DBH, ADCYAP1, CNR1, CRH, SLC6A4
33lithium46 52 25 1211.8SLC6A4, PREP, FKBP5, BDNF, DBH
34nmda46 309.7NPY, DRD2, BDNF, SLC6A4, MAOA, CNR1
356-hydroxydopamine468.7DBH, NPY, BDNF, DRD2, CAT, MAOA
36cocaine46 129.7CNR1, CRH, DBH, NR3C1, NPY, BDNF
375-hydroxytryptamine468.7NPY, DBH, ADCYAP1, CNR1, SLC6A4, DRD2
38nicotine46 30 52 1211.7SLC6A4, NPY, DRD2, CRH, MAOA, CNR1
39indomethacin46 30 62 1211.6BDNF, SOD1, ADCYAP1, FAAH, CNR1, CAT
40epinephrine46 25 1210.6ADCYAP1, MAOA, CRH, DBH, NPY, SLC6A4
41testosterone46 62 25 1211.5MAOA, CRH, NR3C1, NPY, BDNF, FKBP5
42adenylate468.5ADCYAP1R1, NPY, DBH, ADCYAP1, BDNF, DRD2
43norepinephrine46 25 1210.4DBH, ADCYAP1, MAOA, CRH, DRD2, BDNF
44gnrh468.4DBH, SLC6A4, BDNF, NPY, CRH, PREP
45dopamine46 30 25 1211.2DBH, ADCYAP1, CNR1, MAOA, CRH, DRD2
46h2o2467.9DBH, SOD1, ADCYAP1, MAOA, CAT, SLC6A4
47gaba467.9SLC6A4, CNR1, CRH, NR3C1, MAOA, GABRB3
48alanine467.8DBH, SOD1, SLC6A4, FAAH, PREP, CNR1
49cysteine467.5DBH, SOD1, PREP, CNR1, SLC6A4, CRH
50glutamate467.2SLC6A4, SOD1, DBH, NPY, DRD2, CRH

GO Terms for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
17Gene Ontology
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Cellular components related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5BDNF, DBH, SOD1, ADCYAP1, CRH, NPY
2cytoplasmGO:0057377.4SOD1, FKBP5, FAAH, PREP, CRH, NR3C1

Biological processes related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of dopamine secretionGO:03360210.3DRD2, CNR1
2dopamine catabolic processGO:04242010.3DBH, MAOA
3response to painGO:04826510.3DBH, CRH
4positive regulation of growth hormone secretionGO:06012410.3DRD2, ADCYAP1
5behavioral response to ethanolGO:04814910.3DBH, DRD2
6synaptic transmission, dopaminergicGO:00196310.3DRD2, CRH
7regulation of synaptic transmission, GABAergicGO:03222810.2CNR1, DRD2
8associative learningGO:00830610.2DRD2, CRH
9negative regulation of blood pressureGO:04577610.1DRD2, CRH, CNR1
10response to morphineGO:04327810.1CNR1, DRD2
11response to hyperoxiaGO:05509310.1CAT, BDNF
12adrenal gland developmentGO:03032510.0CRH, NR3C1
13response to cocaineGO:04222010.0CNR1, DRD2
14response to nicotineGO:03509410.0DRD2, CNR1
15response to amphetamineGO:0019759.9DBH, SOD1, DRD2
16memoryGO:0076139.9SLC6A4, CNR1, DBH
17behavioral fear responseGO:0016629.9BDNF, ADCYAP1
18locomotory behaviorGO:0076269.9DRD2, SOD1, DBH
19cAMP-mediated signalingGO:0199339.8ADCYAP1R1, ADCYAP1
20feeding behaviorGO:0076319.8CRH, DRD2, NPY, BDNF
21negative regulation of neuron apoptotic processGO:0435249.7BDNF, GABRB3, SOD1
22response to axon injuryGO:0486789.5DRD2, SOD1
23synaptic transmissionGO:0072689.5NPY, GABRB3, CRH, MAOA, DBH
24response to hypoxiaGO:0016669.4CAT, DRD2, BDNF, SLC6A4
25response to ethanolGO:0454719.2CRH, CNR1, ADCYAP1R1, ADCYAP1, SOD1
26response to drugGO:0424938.9SOD1, ADCYAP1R1, CRH, DRD2, SLC6A4

Molecular functions related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4NPY, CRH, ADCYAP1
2receptor bindingGO:0051029.3NPY, CRH, CAT, ADCYAP1

Products for genes affiliated with Post-Traumatic Stress Disorder

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  • Antibodies
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Sources for Post-Traumatic Stress Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet