PTSD
MCID: PST028
MIFTS: 64

Post-Traumatic Stress Disorder (PTSD) malady

Neuronal diseases category

Summaries for Post-Traumatic Stress Disorder

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Post-traumatic stress disorder (ptsd) is a real illness. you can get ptsd after living through or seeing a traumatic event, such as war, a hurricane, sexual assault, physical abuse, or a bad accident. ptsd makes you feel stressed and afraid after the danger is over. it affects your life and the people around you. ptsd can cause problems like flashbacks, or feeling like the event is happening again trouble sleeping or nightmares feeling alone angry outbursts feeling worried, guilty, or sad ptsd starts at different times for different people. signs of ptsd may start soon after a frightening event and then continue. other people develop new or more severe signs months or even years later. ptsd can happen to anyone, even children. treatment may include talk therapy, medicines, or both. treatment might take 6 to 12 weeks. for some people, it takes longer. nih: national institute of mental health

MalaCards: Post-Traumatic Stress Disorder, also known as traumatic neurosis, is related to anxiety disorder and personality disorder. An important gene associated with Post-Traumatic Stress Disorder is CRH (corticotropin releasing hormone), and among its related pathways are Oxidative Stress Regulatory Pathway (Erythrocyte) and superoxide radicals degradation. The drugs carbamazepine and lithium and the compounds sulpiride and topiramate have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and eye, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Disease Ontology:8 An anxiety disorder which results from a traumatic experience that results in psychological trauma.

Wikipedia:63 Posttraumatic stress disorder[note 1] (PTSD) may develop after a person is exposed to one or more... more...

Aliases & Classifications for Post-Traumatic Stress Disorder

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 38NCBI Bookshelf, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

post-traumatic stress disorder 8 10 33 60
traumatic neurosis 8
ptsd 38


External Ids:

Disease Ontology8 DOID:2055
NCIt39 C3389
MeSH34 D013313
ICD9CM27 309.81
ICD1025 F43.1

Related Diseases for Post-Traumatic Stress Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Post-Traumatic Stress Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder31.0BDNF, NPY, DRD2, CRH, MAOA, CNR1
2personality disorder30.9DRD2, MAOA
3psychotic disorder30.8BDNF, DRD2, MAOA, DBH, CNR1
4alcohol dependence30.8NPY, DRD2, CRH, MAOA, CNR1
5borderline personality disorder30.7MAOA
6migraine30.7DRD2, MAOA, DBH, CNR1, ADCYAP1
7mood disorder30.7NR3C1, MAOA, DBH, CNR1, CRH, DRD2
8schizophrenia30.7BDNF, NPY, FAAH, DRD2, PREP, NR3C1
9cocaine dependence30.6DBH, DRD2
10panic disorder30.6MAOA, CRH
11breast cancer30.6FAAH, DRD2, NR3C1, CNR1, ADCYAP1
12heroin dependence30.5DRD2
13generalized anxiety disorder30.5MAOA
14drug dependence30.5DRD2, MAOA, CNR1
15attention deficit hyperactivity disorder30.5BDNF, DRD2, MAOA, DBH
16obesity30.5NPY, FAAH, DRD2, CRH, NR3C1, MAOA
17substance dependence30.3CNR1, DRD2
18substance abuse30.3DRD2, CRH, CNR1
19social phobia30.3MAOA, DRD2
20asthma30.3ADCYAP1, CNR1, NR3C1
21chronic fatigue syndrome30.2ADCYAP1, MAOA, NR3C1, CRH
22dementia30.2MAOA, NR3C1, BDNF
23autistic disorder30.2ADCYAP1, DBH, GABRB3, BDNF
24atherosclerosis30.2CNR1, SOD1, CAT
25bipolar disorder30.2BDNF, NPY, CRH, NR3C1, MAOA
26multiple sclerosis30.2BDNF, NPY, FAAH, DRD2, CNR1, ADCYAP1
27alcohol abuse30.2DRD2
28conduct disorder30.2DRD2, MAOA, DBH
29cocaine abuse30.0DRD2, DBH
30schizoaffective disorder30.0DRD2, BDNF
31nicotine dependence29.8DRD2
32osteoarthritis29.8NR3C1, NPY
33antisocial personality disorder29.8MAOA, DRD2
34combat disorder10.9
35acute stress disorder10.9
36sleep disorder10.7
37dissociative disorder10.6
38sexual disorder10.6
39pain disorder10.6
40major depressive disorder10.5
41physical disorder10.5
42cerebritis10.5
43somatization disorder10.4
44alexithymia10.4
45adjustment disorder10.3
46neuronitis10.3
47acute liver failure10.2
48burns10.2
49paranoid schizophrenia10.2
50crimean-congo hemorrhagic fever10.2

Graphical network of the top 20 diseases related to Post-Traumatic Stress Disorder:



Diseases related to post-traumatic stress disorder

Clinical Features for Post-Traumatic Stress Disorder

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Drugs & Therapeutics for Post-Traumatic Stress Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Post-Traumatic Stress Disorder

Drug clinical trials:

Search ClinicalTrials for Post-Traumatic Stress Disorder

Search NIH Clinical Center for Post-Traumatic Stress Disorder

Search CenterWatch for Post-Traumatic Stress Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Post-Traumatic Stress Disorder

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Anatomical Context for Post-Traumatic Stress Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Post-Traumatic Stress Disorder:

32
Brain, Heart, Eye, Cortex, Prefrontal cortex, Amygdala, Testes, Breast, Pituitary, Lung, Pons, Spinal cord, Occipital lobe, Temporal lobe, Cingulate cortex, Liver, Monocytes, Adrenal gland

Animal Models for Post-Traumatic Stress Disorder or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Post-Traumatic Stress Disorder:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7NPY, DRD2, PREP, NR3C1, CNR1, ADCYAP1
2MP:00053818.7CNR1, NR3C1, GABRB3, DRD2, NPY, BDNF
3MP:00107718.4BDNF, FAAH, DRD2, CRH, NR3C1, DBH
4MP:00053708.3SOD1, NPY, DRD2, PREP, NR3C1, ADCYAP1
5MP:00030128.0BDNF, DRD2, GABRB3, NR3C1, CNR1, ADCYAP1R1
6MP:00028737.5BDNF, NPY, FAAH, GABRB3, CRH, NR3C1
7MP:00053897.4BDNF, SOD1, DRD2, GABRB3, NR3C1, FKBP5
8MP:00053787.0BDNF, NPY, DRD2, GABRB3, CRH, PREP
9MP:00107686.4DRD2, FAAH, SOD1, CAT, BDNF, GABRB3
10MP:00036315.8GABRB3, DRD2, FAAH, NPY, SOD1, BDNF
11MP:00053865.5ADCYAP1R1, BDNF, SOD1, NPY, FAAH, DRD2
12MP:00053765.5DRD2, FAAH, NPY, SOD1, CAT, BDNF

Publications for Post-Traumatic Stress Disorder

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Sources:
50PubMed
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Articles related to Post-Traumatic Stress Disorder:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Evidence-based treatment of post-traumatic stress disorder. (24422573)
2014
2
Gender differences of postdeployment post-traumatic stress disorder among service members and veterans of the iraq and afghanistan conflicts. (23988441)
2014
3
An innovative method to deliver treatment of military sexual trauma and post-traumatic stress disorder. (24083914)
2013
4
A right hemisphere safety backup at work: hypotheses for deep hypnosis, post-traumatic stress disorder, and dissociation identity disorder. (23790686)
2013
5
Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model. (24130763)
2013
6
Plasma concentrations of endocannabinoids and related primary fatty acid amides in patients with post-traumatic stress disorder. (23667516)
2013
7
Drug use disorders and post-traumatic stress disorder over 25 adult years: role of psychopathology in relational networks. (23726975)
2013
8
Post-traumatic stress disorder among asylum seekers and refugees in Istanbul may be predicted by torture and loss due to violence. (23249303)
2013
9
Persistent fear of aftershocks, impairment of working memory, and acute stress disorder predict post-traumatic stress disorder: 6-month follow-up of help seekers following the L'Aquila earthquake. (24324929)
2013
10
Post traumatic stress disorder and resilience in veterans who served in the South African border war. (24173633)
2013
11
Effects of cortisol on memory in women with borderline personality disorder: role of co-morbid post-traumatic stress disorder and major depression. (23171911)
2013
12
Military sexual trauma increases risk of post-traumatic stress disorder and depression thereby amplifying the possibility of suicidal ideation and cardiovascular disease. (23707816)
2013
13
Symptoms and subjective quality of life in post-traumatic stress disorder: a longitudinal study. (23585868)
2013
14
Post-traumatic stress disorder symptoms after acute lung injury: a 2-year prospective longitudinal study. (23438256)
2013
15
Post-traumatic stress disorder and the outcome of dialectical behaviour therapy for borderline personality disorder. (24343961)
2013
16
Post-traumatic stress disorder: a fast track to premature cardiovascular disease? (22717656)
2013
17
Specific Pain Complaints in Iraq and Afghanistan Veterans Screening Positive for Post-Traumatic Stress Disorder. (23473449)
2013
18
Exposure to workplace bullying and post-traumatic stress disorder symptomology: the role of protective psychological resources. (24033807)
2013
19
Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder. (23673864)
2013
20
Perceptual processing advantages for trauma-related visual cues in post-traumatic stress disorder. (21733208)
2012
21
Brief eclectic psychotherapy v. eye movement desensitisation and reprocessing therapy for post-traumatic stress disorder: randomised controlled trial. (22322458)
2012
22
Pharmacotherapy for Post-traumatic Stress Disorder In Combat Veterans: Focus on Antidepressants and Atypical Antipsychotic Agents. (22346334)
2012
23
Psychological therapies for the treatment of post-traumatic stress disorder in children and adolescents. (23235632)
2012
24
Altered emotional interference processing in the amygdala and insula in women with Post-Traumatic Stress Disorder. (24179757)
2012
25
Post-traumatic stress disorder and related factors in parents of children with cancer in South-East of iran. (23483014)
2012
26
On the relationship between beta-blockers, migraines and post-traumatic stress disorder: response to Peterlin et al. (22843223)
2012
27
Lifetime mood symptoms and adult separation anxiety in patients with complicated grief and/or post-traumatic stress disorder: a preliminary report. (22436352)
2012
28
Re-exposure and environmental enrichment reveal NPY-Y1 as a possible target for post-traumatic stress disorder. (22659471)
2012
29
Use of healthcare services 8 years after the war in Kosovo: role of post-traumatic stress disorder and depression. (21746748)
2012
30
Remission from post-traumatic stress disorder in the general population. (22166813)
2012
31
Post-traumatic stress disorder and job stress among firefighters of urban Japan. (22591931)
2012
32
Post-traumatic Stress Disorder and Cardiovascular Disease. (21792377)
2011
33
Post-traumatic stress disorder, child abuse history, birthweight and gestational age: a prospective cohort study. (21790957)
2011
34
Prospective risk factors for new-onset post-traumatic stress disorder in National Guard soldiers deployed to Iraq. (21144108)
2011
35
Unpaired extinction: implications for treating post-traumatic stress disorder. (21074779)
2011
36
Attentional bias in post-traumatic stress disorder diminishes after symptom amelioration. (21924404)
2011
37
Cocaine-related attentional bias following trauma cue exposure among cocaine dependent in-patients with and without post-traumatic stress disorder. (21615582)
2011
38
A diagnostic dilemma between psychosis and post-traumatic stress disorder: a case report and review of the literature. (21392392)
2011
39
In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis. (20716970)
2010
40
Magnetic resonance imaging study of hippocampus structural alterations in post-traumatic stress disorder: a brief review (translated version). (22348867)
2010
41
Post-traumatic stress disorder related to cancer: hope, healing, and recovery. (20797941)
2010
42
Effects of trauma-related audiovisual stimulation on cerebrospinal fluid norepinephrine and corticotropin-releasing hormone concentrations in post-traumatic stress disorder. (18295412)
2008
43
Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder. (18213623)
2008
44
A patient with post-traumatic stress disorder developing stiff person syndrome: is there a correlation? (17558259)
2007
45
Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder. (17245326)
2007
46
The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder. (16632165)
2006
47
From the biology of trauma to secondary preventive pharmalogical measures for post-traumatic stress disorders]. (15959448)
2005
48
Does acute stress disorder predict post-traumatic stress disorder in traffic accident victims? Analysis of a self-report inventory. (15204210)
2004
49
Misidentification of the self in a patient with a psychotic disorder and post-traumatic stress disorder. (14509205)
2003
50
From the jumping Frenchmen of Maine to post-traumatic stress disorder: the startle response in neuropsychiatry. (1410093)
1992

Genetic Variations for Post-Traumatic Stress Disorder

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Expression for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Post-Traumatic Stress Disorder

Search GEO for disease gene expression data for Post-Traumatic Stress Disorder.

Pathways for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 29KEGG
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Compounds for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1sulpiride44 28 1111.9CRH, DRD2, NPY
2topiramate44 11 2411.8CNR1, CRH, NPY
3dopac449.8DBH, MAOA, BDNF
4citalopram49 44 11 2412.8BDNF, FKBP5, MAOA
5oleamide44 28 2411.8MAOA, CNR1, FAAH
6homovanillic acid44 2410.7CRH, BDNF, DBH, MAOA
7maoa449.7DRD2, DBH, BDNF, MAOA
8amphetamine44 1110.7NPY, CNR1, DRD2, MAOA
9nmda44 2810.6BDNF, MAOA, CNR1, ADCYAP1
10semiquinone449.6MAOA, CAT, SOD1
11pacap 38449.6ADCYAP1, NPY, ADCYAP1R1
12morphine44 49 28 1112.6DRD2, CNR1, DBH, ADCYAP1, NR3C1
13opiate449.6NPY, DBH, CRH, DRD2, NR3C1
14mptp449.6DBH, BDNF, DRD2, MAOA
15rasagiline44 1110.6BDNF, CAT, MAOA
16imipramine44 49 28 11 2413.5BDNF, DBH, MAOA, NR3C1
17glutamate449.5MAOA, NPY, PREP, DRD2
18mhpg449.5BDNF, NPY, CRH, MAOA, DBH
19desipramine44 49 1111.5CNR1, MAOA, NR3C1, CRH, BDNF
20cycloheximide449.5CAT, FKBP5
21fluoxetine49 44 28 1112.5MAOA, CRH, BDNF, DRD2, CNR1
22tetrodotoxin44 59 2811.5ADCYAP1, BDNF, NPY, CRH, CNR1
23gnrh449.4PREP, DBH, BDNF, ADCYAP1
24capsaicin44 2810.4CRH, MAOA, CNR1, BDNF, NPY
25benzyl alcohol44 1110.4CAT, SOD1, MAOA
26selegiline44 1110.3MAOA, SOD1, BDNF, CAT
27haloperidol44 28 2 49 1113.3NPY, BDNF, DRD2, ADCYAP1
28catecholamine449.2ADCYAP1, DBH, MAOA, CRH, NPY, BDNF
29carbachol44 28 1111.2NR3C1, CRH, ADCYAP1, CNR1, BDNF, NPY
30acth449.2ADCYAP1, NR3C1, CRH, NPY, BDNF, DBH
315-hydroxytryptamine449.2ADCYAP1, CNR1, DBH, CRH, DRD2, NPY
32nicotine44 49 28 1112.1CNR1, NPY, ADCYAP1, DRD2, CRH, MAOA
33methamphetamine44 49 1111.1BDNF, NPY, FAAH, DRD2, MAOA
34corticosterone44 59 2411.1NR3C1, DBH, CNR1, BDNF, CRH, ADCYAP1
35cocaine44 1110.0CNR1, DBH, CRH, DRD2, NPY, BDNF
36histamine44 28 2411.0DBH, NPY, BDNF, MAOA, CNR1, CRH
37epinephrine44 11 2411.0ADCYAP1, DBH, BDNF, CRH, NPY, DRD2
38ascorbic acid44 249.8CAT, SOD1, BDNF, DBH, MAOA, DRD2
39testosterone44 59 11 2411.8NPY, CRH, MAOA, NR3C1, BDNF, FKBP5
40acetylcholine44 49 28 11 2412.8ADCYAP1, CNR1, DBH, NR3C1, CRH, DRD2
41cyclic amp44 249.8ADCYAP1, NPY, BDNF, CNR1, DBH, CRH
42norepinephrine44 11 2410.7DBH, CNR1, ADCYAP1, MAOA, CRH, DRD2
43levodopa44 119.7MAOA, CAT, DBH, CNR1, SOD1, BDNF
44lactate448.7SOD1, BDNF, NPY, NR3C1, CAT, DBH
456-hydroxydopamine448.6MAOA, CAT, DRD2, SOD1, BDNF, NPY
46dopamine44 28 11 2411.5NPY, ADCYAP1, BDNF, DBH, MAOA, NR3C1
47adenylate448.4NPY, BDNF, DBH, CNR1, ADCYAP1, DRD2
48indomethacin44 59 28 1111.2SOD1, ADCYAP1, CNR1, CRH, FAAH, NPY
49gaba448.2CRH, GABRB3, MAOA, DBH, CNR1, ADCYAP1
50alanine448.1PREP, CRH, FAAH, NPY, SOD1, DBH

GO Terms for genes affiliated with Post-Traumatic Stress Disorder

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Sources:
16Gene Ontology
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Biological processes related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1dopamine catabolic processGO:04242010.2DBH, MAOA
2positive regulation of growth hormone secretionGO:06012410.1DRD2, ADCYAP1
3behavioral response to ethanolGO:04814910.1DRD2, DBH
4response to painGO:04826510.0DBH, CRH
5regulation of synaptic transmission, GABAergicGO:03222810.0DRD2, CNR1
6negative regulation of blood pressureGO:04577610.0DRD2, CRH, CNR1
7synaptic transmission, dopaminergicGO:0019639.9CRH, DRD2
8behaviorGO:0076109.9CNR1, MAOA, NPY
9response to amphetamineGO:0019759.8DBH, DRD2, SOD1
10locomotory behaviorGO:0076269.7SOD1, DRD2, DBH
11feeding behaviorGO:0076319.6BDNF, NPY, DRD2, CRH
12response to hyperoxiaGO:0550939.4CAT, BDNF
13synaptic transmissionGO:0072689.3NPY, GABRB3, CRH, MAOA, DBH
14response to ethanolGO:0454719.0ADCYAP1R1, ADCYAP1, CNR1, CRH, SOD1
15response to drugGO:0424938.9SOD1, DRD2, CRH, ADCYAP1R1

Molecular functions related to Post-Traumatic Stress Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4ADCYAP1, CRH, NPY
2receptor bindingGO:0051029.4ADCYAP1, CRH, NPY, CAT

Products for genes affiliated with Post-Traumatic Stress Disorder

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Sources for Post-Traumatic Stress Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet