MCID: PST086
MIFTS: 33

Posterior Cortical Atrophy malady

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Posterior Cortical Atrophy

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Sources:
51Orphanet, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Posterior Cortical Atrophy:

Name: Posterior Cortical Atrophy 51
Biparietal Alzheimer Disease 51
 
Benson Syndrome 51
Pca 51

Characteristics:

Orphanet epidemiological data:

51
biparietal alzheimer disease:
Age of onset: Adult; Age of death: adult

Classifications:



External Ids:

Orphanet51 54247
ICD10 via Orphanet28 G31.1

Summaries for Posterior Cortical Atrophy

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Wikipedia:68 Posterior cortical atrophy (PCA), also called Benson\'s syndrome, is a form of dementia which is usually... more...

MalaCards based summary: Posterior Cortical Atrophy, also known as biparietal alzheimer disease, is related to cerebritis and amyloidosis, primary localized cutaneous, 1, and has symptoms including oculomotor apraxia, behavioral abnormality and agnosia. An important gene associated with Posterior Cortical Atrophy is APOE (Apolipoprotein E), and among its related pathways are Alzheimers disease and Reelin Pathway (Cajal-Retzius cells). Affiliated tissues include cortex, brain and lung, and related mouse phenotype taste/olfaction.

Related Diseases for Posterior Cortical Atrophy

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Graphical network of the top 20 diseases related to Posterior Cortical Atrophy:



Diseases related to posterior cortical atrophy

Symptoms for Posterior Cortical Atrophy

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Symptoms:

 51 (show all 8)
  • oculomotor apraxia/dyspraxia
  • alexia/agraphia/writing/reading troubles
  • visual/auditory/tactile agnosia/propopagnosia/simultagnosia
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • extrapyramidal syndrome
  • troubles of memory/amnesia/hypermnesia
  • diplopia/double vision
  • psychic/psychomotor regression/dementia/intellectual decline

HPO human phenotypes related to Posterior Cortical Atrophy:

(show all 7)
id Description Frequency HPO Source Accession
1 oculomotor apraxia hallmark (90%) HP:0000657
2 behavioral abnormality hallmark (90%) HP:0000708
3 agnosia hallmark (90%) HP:0010524
4 abnormality of extrapyramidal motor function typical (50%) HP:0002071
5 memory impairment typical (50%) HP:0002354
6 diplopia occasional (7.5%) HP:0000651
7 developmental regression occasional (7.5%) HP:0002376

Drugs & Therapeutics for Posterior Cortical Atrophy

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Drugs for Posterior Cortical Atrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcysteineapprovedPhase 4293616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
2
Cysteamineapproved, investigationalPhase 42360-23-16058
Synonyms:
(2-Mercaptoethyl)amine
(Mercaptoethyl)ammonium toluene-p-sulphonate
.beta.-Mercaptoethylamine
1-Amino-2-mercaptoethylamine
139720-70-0
156-57-0 (hydrochloride)
16904-32-8 (di-hydrochloride)
2-AMINO-ETHANETHIOL
2-AMINO-ethanethiol
2-Amino-1-ethanethiol
2-Aminoethanethiol
2-Aminoethyl mercaptan
2-Mercaptoethanamine
2-Mercaptoethylamine
2-Mercaptoethylamine, polymer-bound
27761-19-9 (tartrate (1:1))
2DFDA1F8-7010-4225-8280-AB1C4C43F546
30070_FLUKA
30070_SIGMA
3037-04-5
3037-04-5 (tosylate)
42954-15-4 (hydrobromide)
60-23-1
60-23-1 (Parent)
641022_ALDRICH
93965-19-6 (maleate (1:1))
A0648
AC1L1LPL
AC1Q54NL
AKOS003793343
Aminoethyl mercaptan
Becaptan
C-9500
C01678
C2H7NS
CASH
CCRIS 3083
CHEBI:17141
CHEMBL602
CID6058
CYSTEAMINE
Cisteamina
Cisteamina [Italian]
Cystagon
Cystaran
Cystavision
Cysteamide
Cysteamin
Cysteamine
Cysteamine (USAN)
Cysteamine Bitartrate
Cysteamine Hydrochloride
Cysteamine [USAN:BAN]
Cysteamine bitartate
Cysteamine hydrochloride
Cysteaminium
Cysteinamine
D03634
DB00847
 
Decarboxycysteine
DivK1c_006750
EINECS 200-463-0
EINECS 221-235-7
Ethanethiolamine
HSDB 7353
KBio1_001694
KBio2_002235
KBio2_004803
KBio2_007371
KBioSS_002235
L 1573
L-1573
LS-65761
Lambraten
Lambratene
Lopac-M-6500
M9768_ALDRICH
M9768_SIGMA
MEA
MEA (mercaptan)
Mecramine
Mercamin
Mercamine
Mercaptamin
Mercaptamina
Mercaptamina [INN-Spanish]
Mercaptamine
Mercaptamine (INN)
Mercaptaminum
Mercaptaminum [INN-Latin]
Mercaptoethylamine
Merkamin
MolPort-001-662-635
NCGC00015691-01
NCGC00015691-04
NCGC00162236-01
NCI60_002000
NSC 647528
NSC647528
Riacon
STK315355
SpecPlus_000654
Spectrum_001755
Thioethanolamine
UNII-5UX2SD1KE2
WR 347
b-Aminoethanethiol
b-Aminoethylthiol
b-Mercaptoethylamine
beta-Aminoethanethiol
beta-Aminoethylthiol
beta-MEA
beta-Mercaptoethylamine
bmse000388
cysteamine bitartrate
nchembio.315-comp1
nchembio.316-comp1
╬▓-MEA
╬▓-aminoethylthiol
3Protective AgentsPhase 45651
4Respiratory System AgentsPhase 43931
5N-monoacetylcystinePhase 4293
6ExpectorantsPhase 4337
7Antiviral AgentsPhase 48071
8Anti-Infective AgentsPhase 417220
9AntioxidantsPhase 42442
10
CorticosteronePhase 1950-22-65753
Synonyms:
11,21-Dihydroxypregn-4-ene-3,20-dione
11,21-Dihydroxyprogesterone
11-Hydroxycorticoaldosterone
 
17-Deoxycortisol
4-Pregnene-11 Corticosteron
Corticosterone
Kendall'S compound B
Reichstein'S substance H

Interventional clinical trials:

idNameStatusNCT IDPhase
1Cystagon to Treat Infantile Neuronal Ceroid LipofuscinosisCompletedNCT00028262Phase 4
2Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical ADCompletedNCT01723553Phase 1
3Buccal Fat Pad Derived Stem Cells With Cortical Tenting in Posterior Mandible ReconstructionRecruitingNCT02745366Phase 1
4Influence of Age on Amyloid Load in Alzheimer's Disease and in Atypical Focal Cortical Alzheimer's DiseaseCompletedNCT01095744
5Emotional Communication Disorders in Cerebellar DiseaseRecruitingNCT02106819
6Tau Imaging in Young Onset DementiaActive, not recruitingNCT02289118
7Molecular and Structural Imaging in Atypical Alzheimer's Disease: A Longitudinal StudyNot yet recruitingNCT02740634
8PET Imaging in Chronic Traumatic EncephalopathySuspendedNCT02211820

Search NIH Clinical Center for Posterior Cortical Atrophy

Genetic Tests for Posterior Cortical Atrophy

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Anatomical Context for Posterior Cortical Atrophy

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MalaCards organs/tissues related to Posterior Cortical Atrophy:

33
Cortex, Brain, Lung, Liver, Ovary, Kidney, Heart

Animal Models for Posterior Cortical Atrophy or affiliated genes

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MGI Mouse Phenotypes related to Posterior Cortical Atrophy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1APOE, MAPT

Publications for Posterior Cortical Atrophy

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Articles related to Posterior Cortical Atrophy:

(show top 50)    (show all 152)
idTitleAuthorsYear
1
The importance of rs1021737 and rs482843 polymorphisms of cystathionine gamma-lyase in the etiology of preeclampsia in the Caucasian population. (25807836)
2015
2
Epidemiological Survey of Severe Fever with Thrombocytopenia Syndrome Virus in Ticks in Nagasaki, Japan. (26543390)
2015
3
Step-rate thresholds for physical activity intensity in persons with multiple sclerosis. (24385438)
2014
4
Medical marijuana for chronic pain. (23940889)
2013
5
A pilot newborn screening program for Mucopolysaccharidosis type I in Taiwan. (24053568)
2013
6
Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. (23694951)
2013
7
Increased use of antimicrobial agents and hospital admission for infections in patients with primary adrenal insufficiency: a cohort study. (23384710)
2013
8
BK virus-associated urinary bladder carcinoma in transplant recipients: report of 2 cases, review of the literature, and proposed pathogenetic model. (23317548)
2013
9
The practical implications of TARGET for adenoidectomy in children with otitis media with effusion. (22708935)
2012
10
PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule? (20060369)
2010
11
Incidence of atazanavir-associated hyperbilirubinemia in Korean HIV patients: 30 months follow-up results in a population with low UDP-glucuronosyltransferase1A1*28 allele frequency. (20890421)
2010
12
Hyperlipidemia: a new therapeutic target for diabetic neuropathy. (20021567)
2009
13
Generalized pustular psoriasis of pregnancy successfully treated with cyclosporine. (19915261)
2009
14
Correction of proptosis and zygomaticomaxillary asymmetry using orbital wall decompression and zygoma reduction in craniofacial fibrous dysplasia. (19276831)
2009
15
Mechanical force enhances MMP-2 activation via p38 signaling pathway in human retinal pigment epithelial cells. (19590887)
2009
16
Paraneoplastic refractory hypercalcemia due to advanced metastatic esthesioneuroblastoma. (18575019)
2008
17
Fulvestrant (Faslodex), an estrogen selective receptor downregulator, in therapy of women with systemic lupus erythematosus. clinical, serologic, bone density, and T cell activation marker studies: a double-blind placebo-controlled trial. (18381791)
2008
18
Clearance of acanthosis nigricans associated with insulinoma following surgical resection. (18669553)
2008
19
BetaIg-h3 is involved in the HAb18G/CD147-mediated metastasis process in human hepatoma cells. (17327467)
2007
20
Interactions between insulin, body fat, and insulin-like growth factor axis proteins. (17372257)
2007
21
Hepatic stellate cells and oxidative stress]. (17590105)
2007
22
Aortic valve replacement improves survival in severe aortic stenosis associated with severe pulmonary hypertension. (17588389)
2007
23
Xanthogranulomatous pyelonephritis complicated by emphysematous pyelonephritis in a hemodialysis patient. (18184527)
2007
24
beta-Tubulin mutations in ovarian cancer using single strand conformation analysis-risk of false positive results from paraffin embedded tissues. (16002208)
2006
25
NF-kappaB: linking inflammation and immunity to cancer development and progression. (16175180)
2005
26
Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-reactivity by an autoantibody. (15488942)
2005
27
The human cytomegalovirus-encoded chemokine receptor US28 induces caspase-dependent apoptosis. (16098198)
2005
28
The first description of sentinel node biopsy in a patient with amelanotic melanoma of the glans penis. (16314746)
2005
29
No correlation between mini-nutritional assessment (short form) scale and clinical outcomes in 73 elderly patients admitted for hip fracture. (16285202)
2005
30
Thyrotropin-secreting pituitary adenoma:a clinicopathological analysis of seven cases]. (15256109)
2004
31
Coexpression of yeast copper chaperone (yCCS) and CuZn-superoxide dismutases in Escherichia coli yields protein with high copper contents. (15358352)
2004
32
A case of herpetiform pemphigus with anti-desmoglein 3 IgG autoantibodies. (15187309)
2004
33
Complete primary structure and genomic organization of the mouse Col14a1 gene. (12853031)
2003
34
Induction chemotherapy for breast carcinoma: predictive markers and relation with outcome. (12739000)
2003
35
Species-specific inhibition of porphobilinogen synthase by 4-oxosebacic acid. (11909869)
2002
36
Anterior ischemic optic neuropathy after a trans-Atlantic airplane journey. (11931805)
2002
37
Intramedullary subependymoma occupying the right half of the thoracic spinal cord--case report. (12206490)
2002
38
Identification of the gene causing mucolipidosis type IV. (10973263)
2000
39
Different point mutations in the met oncogene elicit distinct biological properties. (10657996)
2000
40
Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. (10097103)
1999
41
Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis. (10461473)
1999
42
Increase in urinary excretion of 6beta-hydroxycortisol in common marmosets as a marker of hepatic CYP3A induction. (10463384)
1999
43
Retinoic acid-induced differentiation in a human neuroblastoma cell line is associated with an increase in nitric oxide synthesis. (9397160)
1998
44
Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers. (9227717)
1997
45
Pleural tuberculosis in patients infected with HIV in Addis Ababa. (9164013)
1996
46
Muscarinic M2 receptor synthesis: study of receptor turnover with propylbenzilylcholine mustard. (7589214)
1995
47
Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. (1280332)
1992
48
Pericardial mesothelioma. A pediatric case report. (2486430)
1989
49
Group A streptococcal pyrogenic exotoxin (scarlet fever toxin) type A and blastogen A are the same protein. (2498210)
1989
50
ERYTHROPOIETIC PROTOPORPHYRIA. A NEW TYPE OF INBORN ERROR OF METABOLISM. (14072370)
1963

Variations for Posterior Cortical Atrophy

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Expression for genes affiliated with Posterior Cortical Atrophy

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Search GEO for disease gene expression data for Posterior Cortical Atrophy.

Pathways for genes affiliated with Posterior Cortical Atrophy

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Pathways related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.1APOE, MAPT
29.1APOE, MAPT
39.1APOE, MAPT

GO Terms for genes affiliated with Posterior Cortical Atrophy

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Cellular components related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:00304259.1APOE, MAPT

Sources for Posterior Cortical Atrophy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet