PCA
MCID: PST086
MIFTS: 37

Posterior Cortical Atrophy (PCA) malady

Neuronal diseases, Rare diseases categories

Summaries for Posterior Cortical Atrophy

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66Wikipedia, 34MalaCards
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Wikipedia:66 Posterior cortical atrophy (PCA), also called Benson\'s syndrome, is a form of dementia which is usually... more...

MalaCards: Posterior Cortical Atrophy, also known as biparietal alzheimer disease, is related to alzheimer's disease and dementia. An important gene associated with Posterior Cortical Atrophy is MAPT (microtubule-associated protein tau), and among its related pathways are Neuroscience and Alzheimer's disease. The compounds thioflavine s and tacrine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and testes, and related mouse phenotypes are other and taste/olfaction.

Aliases & Classifications for Posterior Cortical Atrophy

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Sources:
50Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
biparietal alzheimer disease:
Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

posterior cortical atrophy 50
biparietal alzheimer disease 50
benson syndrome 50
pca 50


External Ids:

ICD10 via Orphanet27 G31.1

Related Diseases for Posterior Cortical Atrophy

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Posterior Cortical Atrophy:



Diseases related to posterior cortical atrophy

Symptoms for Posterior Cortical Atrophy

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Drugs & Therapeutics for Posterior Cortical Atrophy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Posterior Cortical Atrophy

Drug clinical trials:

Search ClinicalTrials for Posterior Cortical Atrophy

Search NIH Clinical Center for Posterior Cortical Atrophy

Search CenterWatch for Posterior Cortical Atrophy

Genetic Tests for Posterior Cortical Atrophy

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Anatomical Context for Posterior Cortical Atrophy

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34MalaCards
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MalaCards organs/tissues related to Posterior Cortical Atrophy:

34
Cortex, Brain, Testes

Animal Models for Posterior Cortical Atrophy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Posterior Cortical Atrophy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1MAPT, APOE
2MP:00053948.8MAPT, APOE

Publications for Posterior Cortical Atrophy

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53PubMed
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Articles related to Posterior Cortical Atrophy:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Shining a light on posterior cortical atrophy. (23274153)
2013
2
Olfactory impairment in posterior cortical atrophy. (23435114)
2013
3
Visual impairment and posterior cortical atrophy preceding rapid progressive dementia. (23283613)
2013
4
Posterior cortical atrophy: an investigation of scan paths generated during face matching tasks. (23825453)
2013
5
Logopenic syndrome in posterior cortical atrophy. (23007194)
2013
6
Towards an earlier diagnosis of Alzheimer's disease presenting with visuospatial disorders (posterior cortical atrophy). (24035594)
2013
7
Aphasia with left occipitotemporal hypometabolism: a novel presentation of posterior cortical atrophy? (23850398)
2013
8
Posterior cortical atrophy: visuomotor deficits in reaching and grasping. (23801956)
2013
9
A patient with posterior cortical atrophy possesses a novel mutation in the presenilin 1 gene. (23593396)
2013
10
Posterior cortical atrophy--a prototypical case of dementia beginning with visual symptoms: case report. (24232949)
2013
11
Ophthalmic impairment or higher-order visual deficit? Posterior cortical atrophy: a case report. (23373584)
2012
12
Visuospatial deficits in posterior cortical atrophy: structural and functional correlates. (22645257)
2012
13
Brain networks in posterior cortical atrophy: a single case tractography study and literature review. (22099855)
2012
14
Long-standing prion dementia manifesting as posterior cortical atrophy. (21959360)
2012
15
Huntington's disease presenting as posterior cortical atrophy. (21625777)
2011
16
Posterior cortical atrophy: an exemplar for renovating diagnostic formulation in neuropsychiatry. (21497228)
2011
17
The evolution of alexia in two cases of posterior cortical atrophy. (21876262)
2011
18
Abnormal visual phenomena in posterior cortical atrophy. (20818540)
2011
19
Similar amyloid-I^ burden in posterior cortical atrophy and Alzheimer's disease. (21705422)
2011
20
Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome. (21912890)
2011
21
Presenile dementia diagnosed as posterior cortical atrophy. (21951958)
2011
22
Basic visual function and cortical thickness patterns in posterior cortical atrophy. (21310781)
2011
23
Visuo-spatial imagery impairment in posterior cortical atrophy: a cognitive and SPECT study. (21606573)
2011
24
Computerized visual field defects in posterior cortical atrophy. (22131540)
2011
25
Posterior cortical atrophy: a rare visual variant of Alzheimer's disease. (21743197)
2011
26
Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer's disease. (19781814)
2011
27
Cognitive rehabilitation in posterior cortical atrophy. (20306369)
2010
28
Visual impairments in dementia with Lewy bodies and posterior cortical atrophy. (20063945)
2010
29
Action-intentional spatial bias in a patient with posterior cortical atrophy. (20672222)
2010
30
Processing of wh-questions in a case of posterior cortical atrophy. (21271923)
2009
31
Pattern and progression of white-matter changes in a case of posterior cortical atrophy using diffusion tensor imaging. (19289480)
2009
32
The role of neuropsychology in distinguishing the posterior cortical atrophy syndrome and Alzheimer's disease. (19542605)
2009
33
Use of the Visual Object and Space Perception (VOSP) test battery in two cases of posterior cortical atrophy. (19031338)
2008
34
Atrophy and decreased activation of fronto-parietal attention areas contribute to higher visual dysfunction in posterior cortical atrophy. (18945600)
2008
35
Posterior cortical atrophy: a rare form of dementia with in vivo evidence of amyloid-beta accumulation. (18997288)
2008
36
Risperidone treatment of complex hallucinations in a patient with posterior cortical atrophy. (18806250)
2008
37
Foveal crowding in posterior cortical atrophy: a specific early-visual-processing deficit affecting word reading. (18161498)
2007
38
Imaging correlates of posterior cortical atrophy. (16797786)
2007
39
Exploded drawing in posterior cortical atrophy. (17130426)
2006
40
Visual hallucinations in posterior cortical atrophy. (17030659)
2006
41
What are we seeing? Is posterior cortical atrophy just Alzheimer disease? (16476924)
2006
42
A case of progressive posterior cortical atrophy (PCA) with vivid hallucination: are some ghost tales vivid hallucinations in normal people? (16484663)
2006
43
Posterior cortical atrophy: a review of the literature. (15788276)
2004
44
Cortical sensory loss in a patient with posterior cortical atrophy: a case report. (15849159)
2004
45
Simultanagnosia in posterior cortical atrophy. (11796782)
2002
46
Dementia following posterior cortical atrophy--a descriptive clinical case report. (15374033)
2001
47
Alexia and agraphia in posterior cortical atrophy. (9118197)
1997
48
Posterior cortical atrophy: neuropathological correlations. (8859056)
1996
49
Posterior cortical atrophy in Alzheimer's disease: analysis of a new case and re-evaluation of a historical report. (8213079)
1993
50
Alzheimer's disease in a patient with posterior cortical atrophy. (1783928)
1991

Variations for Posterior Cortical Atrophy

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Expression for genes affiliated with Posterior Cortical Atrophy

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Posterior Cortical Atrophy

Search GEO for disease gene expression data for Posterior Cortical Atrophy.

Pathways for genes affiliated with Posterior Cortical Atrophy

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Sources:
51PathCards, 5Cell Signaling Technology, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN
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Pathways related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1MAPT, APOE
2
Show member pathways
Alzheimers Disease39
9.1MAPT, APOE
39.1MAPT, APOE
49.1MAPT, APOE

Compounds for genes affiliated with Posterior Cortical Atrophy

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1thioflavine s469.5MAPT, APOE
2tacrine46 1210.5MAPT, APOE
3donepezil46 52 25 1212.5MAPT, APOE
4galantamine46 52 1211.5MAPT, APOE
5formate469.5APOE, MAPT
6guanidine46 25 1211.5MAPT, APOE
7spec-t469.5MAPT, APOE
8vitamin b12469.5MAPT, APOE
94-hydroxynonenal46 2510.5APOE, MAPT
10chloroquine46 3 52 30 1213.5MAPT, APOE
11lactacystin469.5MAPT, APOE
12kainate46 3010.5MAPT, APOE
13sodium dodecylsulfate469.5APOE, MAPT
14folate469.5MAPT, APOE
15nicotine46 30 52 1212.5MAPT, APOE
16valine469.5MAPT, APOE
17n acetylcysteine469.4APOE, MAPT
18nmda46 3010.4MAPT, APOE
19acetylcholine46 52 30 25 1213.4MAPT, APOE
20actinomycin d469.4MAPT, APOE
21paraffin469.4APOE, MAPT
22cyclosporin a46 30 6211.4MAPT, APOE
23glutamine469.4MAPT, APOE
24dopamine46 30 25 1212.4MAPT, APOE
25creatinine469.3APOE, MAPT
26aspartate469.3MAPT, APOE
27heparin46 30 25 1212.3MAPT, APOE
28cycloheximide469.2MAPT, APOE
29h2o2469.2APOE, MAPT
30testosterone46 62 25 1212.1MAPT, APOE
31alanine469.1MAPT, APOE
32arginine469.0MAPT, APOE
33glutamate468.8MAPT, APOE

GO Terms for genes affiliated with Posterior Cortical Atrophy

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Sources:
17Gene Ontology
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Biological processes related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of axon extensionGO:0457739.1MAPT, APOE

Molecular functions related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.1MAPT, APOE

Products for genes affiliated with Posterior Cortical Atrophy

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  • Antibodies
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Sources for Posterior Cortical Atrophy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet