PCA
MCID: PST086
MIFTS: 38

Posterior Cortical Atrophy (PCA) malady

Neuronal diseases, Rare diseases categories
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Summaries for Posterior Cortical Atrophy

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Wikipedia:65 Posterior cortical atrophy (PCA), also called Benson\'s syndrome, is a form of dementia which is usually... more...

MalaCards based summary: Posterior Cortical Atrophy, also known as biparietal alzheimer disease, is related to alzheimer's disease and dementia. An important gene associated with Posterior Cortical Atrophy is MAPT (microtubule-associated protein tau), and among its related pathways are Neuroscience and Alzheimer's disease. The compounds thioflavine s and tacrine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and testes, and related mouse phenotypes are other and taste/olfaction.

Aliases & Classifications for Posterior Cortical Atrophy

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Sources:
48Orphanet, 26ICD10 via Orphanet
See all sources

Posterior Cortical Atrophy, Aliases & Descriptions:

Name: Posterior Cortical Atrophy 48
Biparietal Alzheimer Disease 48
 
Benson Syndrome 48
Pca 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
biparietal alzheimer disease:
Age of onset: Adulthood; Age of death: Adult


External Ids:

ICD10 via Orphanet26 G31.1

Related Diseases for Posterior Cortical Atrophy

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Graphical network of the top 20 diseases related to Posterior Cortical Atrophy:



Diseases related to posterior cortical atrophy

Symptoms for Posterior Cortical Atrophy

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Drugs & Therapeutics for Posterior Cortical Atrophy

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Drug clinical trials:

Search ClinicalTrials for Posterior Cortical Atrophy

Search NIH Clinical Center for Posterior Cortical Atrophy

Genetic Tests for Posterior Cortical Atrophy

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Anatomical Context for Posterior Cortical Atrophy

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MalaCards organs/tissues related to Posterior Cortical Atrophy:

32
Cortex, Brain, Testes, Endothelial

Animal Models for Posterior Cortical Atrophy or affiliated genes

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MGI Mouse Phenotypes related to Posterior Cortical Atrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1MAPT, APOE
2MP:00053948.8MAPT, APOE

Publications for Posterior Cortical Atrophy

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Articles related to Posterior Cortical Atrophy:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
(Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy. (24841985)
2014
2
Brain Changes within the Visuo-Spatial Attentional Network in Posterior Cortical Atrophy. (25114070)
2014
3
Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD. (24670887)
2014
4
The progression of posterior cortical atrophy to corticobasal syndrome: lumping or splitting neurodegenerative diseases? (25009764)
2014
5
Hiding in plain sight: a closer look at posterior cortical atrophy. (25216669)
2014
6
Upside-down Drawing in Posterior Cortical Atrophy. (25373818)
2014
7
The Neuropsychiatric Profile of Posterior Cortical Atrophy. (25330926)
2014
8
Visual field defect as an uncommon presentation of posterior cortical atrophy. (25327905)
2014
9
Further evidence about the crucial role of CSF biomarkers in diagnosis of posterior cortical atrophy. (24487699)
2014
10
Shining a light on posterior cortical atrophy. (23274153)
2013
11
Visual impairment and posterior cortical atrophy preceding rapid progressive dementia. (23283613)
2013
12
Posterior cortical atrophy: an investigation of scan paths generated during face matching tasks. (23825453)
2013
13
Logopenic syndrome in posterior cortical atrophy. (23007194)
2013
14
Towards an earlier diagnosis of Alzheimer's disease presenting with visuospatial disorders (posterior cortical atrophy). (24035594)
2013
15
Aphasia with left occipitotemporal hypometabolism: a novel presentation of posterior cortical atrophy? (23850398)
2013
16
Posterior cortical atrophy: visuomotor deficits in reaching and grasping. (23801956)
2013
17
Ophthalmic impairment or higher-order visual deficit? Posterior cortical atrophy: a case report. (23373584)
2012
18
Visuospatial deficits in posterior cortical atrophy: structural and functional correlates. (22645257)
2012
19
Brain networks in posterior cortical atrophy: a single case tractography study and literature review. (22099855)
2012
20
Long-standing prion dementia manifesting as posterior cortical atrophy. (21959360)
2012
21
Huntington's disease presenting as posterior cortical atrophy. (21625777)
2011
22
Posterior cortical atrophy: an exemplar for renovating diagnostic formulation in neuropsychiatry. (21497228)
2011
23
The evolution of alexia in two cases of posterior cortical atrophy. (21876262)
2011
24
Abnormal visual phenomena in posterior cortical atrophy. (20818540)
2011
25
Similar amyloid-I^ burden in posterior cortical atrophy and Alzheimer's disease. (21705422)
2011
26
Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome. (21912890)
2011
27
Presenile dementia diagnosed as posterior cortical atrophy. (21951958)
2011
28
Basic visual function and cortical thickness patterns in posterior cortical atrophy. (21310781)
2011
29
Visuo-spatial imagery impairment in posterior cortical atrophy: a cognitive and SPECT study. (21606573)
2011
30
Cognitive rehabilitation in posterior cortical atrophy. (20306369)
2010
31
Visual impairments in dementia with Lewy bodies and posterior cortical atrophy. (20063945)
2010
32
Action-intentional spatial bias in a patient with posterior cortical atrophy. (20672222)
2010
33
Processing of wh-questions in a case of posterior cortical atrophy. (21271923)
2009
34
Pattern and progression of white-matter changes in a case of posterior cortical atrophy using diffusion tensor imaging. (19289480)
2009
35
The role of neuropsychology in distinguishing the posterior cortical atrophy syndrome and Alzheimer's disease. (19542605)
2009
36
Use of the Visual Object and Space Perception (VOSP) test battery in two cases of posterior cortical atrophy. (19031338)
2008
37
Atrophy and decreased activation of fronto-parietal attention areas contribute to higher visual dysfunction in posterior cortical atrophy. (18945600)
2008
38
Posterior cortical atrophy: a rare form of dementia with in vivo evidence of amyloid-beta accumulation. (18997288)
2008
39
Foveal crowding in posterior cortical atrophy: a specific early-visual-processing deficit affecting word reading. (18161498)
2007
40
Exploded drawing in posterior cortical atrophy. (17130426)
2006
41
Visual hallucinations in posterior cortical atrophy. (17030659)
2006
42
What are we seeing? Is posterior cortical atrophy just Alzheimer disease? (16476924)
2006
43
A case of progressive posterior cortical atrophy (PCA) with vivid hallucination: are some ghost tales vivid hallucinations in normal people? (16484663)
2006
44
Posterior cortical atrophy: a review of the literature. (15788276)
2004
45
Cortical sensory loss in a patient with posterior cortical atrophy: a case report. (15849159)
2004
46
Dementia following posterior cortical atrophy--a descriptive clinical case report. (15374033)
2001
47
Alexia and agraphia in posterior cortical atrophy. (9118197)
1997
48
Posterior cortical atrophy: neuropathological correlations. (8859056)
1996
49
Posterior cortical atrophy in Alzheimer's disease: analysis of a new case and re-evaluation of a historical report. (8213079)
1993
50
Alzheimer's disease in a patient with posterior cortical atrophy. (1783928)
1991

Variations for Posterior Cortical Atrophy

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Expression for genes affiliated with Posterior Cortical Atrophy

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Expression patterns in normal tissues for genes affiliated with Posterior Cortical Atrophy

Search GEO for disease gene expression data for Posterior Cortical Atrophy.

Pathways for genes affiliated with Posterior Cortical Atrophy

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Pathways related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1MAPT, APOE
2
Show member pathways
Alzheimers Disease37
9.1MAPT, APOE
39.1MAPT, APOE
49.1MAPT, APOE

Compounds for genes affiliated with Posterior Cortical Atrophy

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Compounds related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1thioflavine s449.5MAPT, APOE
2tacrine44 1110.5MAPT, APOE
3donepezil44 50 24 1112.5MAPT, APOE
4galantamine44 50 1111.5MAPT, APOE
5formate449.5APOE, MAPT
6guanidine44 24 1111.5MAPT, APOE
7spec-t449.5MAPT, APOE
8vitamin b12449.5MAPT, APOE
94-hydroxynonenal44 2410.5APOE, MAPT
10chloroquine44 2 50 28 1113.5MAPT, APOE
11lactacystin449.5MAPT, APOE
12kainate44 2810.5MAPT, APOE
13sodium dodecylsulfate449.5APOE, MAPT
14folate449.5MAPT, APOE
15nicotine44 28 50 1112.5MAPT, APOE
16valine449.5MAPT, APOE
17n acetylcysteine449.4APOE, MAPT
18nmda44 2810.4MAPT, APOE
19acetylcholine44 50 28 24 1113.4MAPT, APOE
20actinomycin d449.4MAPT, APOE
21paraffin449.4APOE, MAPT
22cyclosporin a44 28 6111.4MAPT, APOE
23glutamine449.4MAPT, APOE
24dopamine44 28 24 1112.4MAPT, APOE
25creatinine449.3APOE, MAPT
26aspartate449.3MAPT, APOE
27heparin44 28 24 1112.3MAPT, APOE
28cycloheximide449.2MAPT, APOE
29h2o2449.2APOE, MAPT
30testosterone44 61 24 1112.1MAPT, APOE
31alanine449.1MAPT, APOE
32arginine449.0MAPT, APOE
33glutamate448.8MAPT, APOE

GO Terms for genes affiliated with Posterior Cortical Atrophy

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Biological processes related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of axon extensionGO:0457739.1MAPT, APOE

Molecular functions related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.1MAPT, APOE

Products for genes affiliated with Posterior Cortical Atrophy

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  • Antibodies
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Sources for Posterior Cortical Atrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet