PCA
MCID: PST086
MIFTS: 32

Posterior Cortical Atrophy (PCA) malady

Neuronal category

Summaries for Posterior Cortical Atrophy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Posterior cortical atrophy (PCA), also called Benson\'s syndrome, is a form of dementia which is usually... more...

MalaCards: Posterior Cortical Atrophy, also known as biparietal alzheimer disease, is related to aphasia and frontotemporal dementia. An important gene associated with Posterior Cortical Atrophy is MAPT (microtubule-associated protein tau), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. The compounds thioflavine s and tacrine have been mentioned in the context of this disorder. Affiliated tissues include brain and cortex, and related mouse phenotypes are other and taste/olfaction.

Aliases & Classifications for Posterior Cortical Atrophy

Sources:
49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
biparietal alzheimer disease:
Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

posterior cortical atrophy 49
biparietal alzheimer disease 49
benson syndrome 49
pca 49


External Ids:

ICD10 via Orphanet26 G31.1

Related Diseases for Posterior Cortical Atrophy

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Posterior Cortical Atrophy:



Diseases related to posterior cortical atrophy

Clinical Features for Posterior Cortical Atrophy

Drugs & Therapeutics for Posterior Cortical Atrophy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Posterior Cortical Atrophy

Drug clinical trials:

Search ClinicalTrials for Posterior Cortical Atrophy

Search NIH Clinical Center for Posterior Cortical Atrophy

Search CenterWatch for Posterior Cortical Atrophy

Genetic Tests for Posterior Cortical Atrophy

Anatomical Context for Posterior Cortical Atrophy

Sources:
33MalaCards
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MalaCards organs/tissues related to Posterior Cortical Atrophy:

33
Brain, Cortex

Animal Models for Posterior Cortical Atrophy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Posterior Cortical Atrophy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1MAPT, APOE
2MP:00053948.8MAPT, APOE

Publications for Posterior Cortical Atrophy

Sources:
51PubMed
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Articles related to Posterior Cortical Atrophy:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Quantitative regional validation of the visual rating scale for posterior cortical atrophy. (24092044)
2014
2
Olfactory impairment in posterior cortical atrophy. (23435114)
2013
3
Visual impairment and posterior cortical atrophy preceding rapid progressive dementia. (23283613)
2013
4
Posterior cortical atrophy: an investigation of scan paths generated during face matching tasks. (23825453)
2013
5
Logopenic syndrome in posterior cortical atrophy. (23007194)
2013
6
Posterior cortical atrophy: visuomotor deficits in reaching and grasping. (23801956)
2013
7
Visuospatial deficits and hemispheric perfusion asymmetries in posterior cortical atrophy. (22513341)
2013
8
Scene perception in posterior cortical atrophy: categorization, description and fixation patterns. (24106469)
2013
9
Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging? (22809815)
2013
10
The language profile of posterior cortical atrophy. (23138762)
2013
11
Seeing why they cannot see: Understanding the syndrome and causes of posterior cortical atrophy. (23458247)
2013
12
Confirmation of the amyloidogenic process in posterior cortical atrophy: value of the AI^42/AI^40 ratio. (22986776)
2013
13
Ophthalmic impairment or higher-order visual deficit? Posterior cortical atrophy: a case report. (23373584)
2012
14
Visuospatial deficits in posterior cortical atrophy: structural and functional correlates. (22645257)
2012
15
Posterior cortical atrophy: a case study of Benson's syndrome that initially presented as anxiety disorder. (23373609)
2012
16
Physical medicine and rehabilitation multidisciplinary approach in a case of posterior cortical atrophy. (22771215)
2012
17
Ventral and dorsal visual streams in posterior cortical atrophy: a DT MRI study. (22277261)
2012
18
Posterior cortical atrophy. (22265212)
2012
19
Picture agnosia as a characteristic of posterior cortical atrophy. (22710605)
2012
20
Visualizing the emergence of posterior cortical atrophy. (22026812)
2012
21
Global gray matter changes in posterior cortical atrophy: a serial imaging study. (22365384)
2012
22
Posterior cortical atrophy: an exemplar for renovating diagnostic formulation in neuropsychiatry. (21497228)
2011
23
Similar amyloid-I^ burden in posterior cortical atrophy and Alzheimer's disease. (21705422)
2011
24
Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome. (21912890)
2011
25
Presenile dementia diagnosed as posterior cortical atrophy. (21951958)
2011
26
Frontotemporal dementia with parkinsonism presenting as posterior cortical atrophy. (21618283)
2011
27
Posterior cortical atrophy: evidence for discrete syndromes of early-onset Alzheimer's disease. (21831859)
2011
28
Action-intentional spatial bias in a patient with posterior cortical atrophy. (20672222)
2010
29
Pattern and progression of white-matter changes in a case of posterior cortical atrophy using diffusion tensor imaging. (19289480)
2009
30
Posterior cortical atrophy: a rare form of dementia with in vivo evidence of amyloid-beta accumulation. (18997288)
2008
31
Residual perception of moving objects: dissociation of moving and static objects in a case of posterior cortical atrophy. (18285689)
2008
32
Foveal crowding in posterior cortical atrophy: a specific early-visual-processing deficit affecting word reading. (18161498)
2007
33
Imaging correlates of posterior cortical atrophy. (16797786)
2007
34
Exploded drawing in posterior cortical atrophy. (17130426)
2006
35
What are we seeing? Is posterior cortical atrophy just Alzheimer disease? (16476924)
2006
36
A case of progressive posterior cortical atrophy (PCA) with vivid hallucination: are some ghost tales vivid hallucinations in normal people? (16484663)
2006
37
The cognitive profile of posterior cortical atrophy. (16476930)
2006
38
Posterior cortical atrophy: a brief review. (17074282)
2006
39
Atypical posterior cortical atrophy: a diagnostic and treatment dilemma. (16774664)
2006
40
Isolated numerical skills in posterior cortical atrophy--an fMRI study. (16597450)
2006
41
A case with cholinesterase inhibitor responsive asymmetric posterior cortical atrophy. (16311158)
2005
42
Posterior cortical atrophy: clinical presentation and cognitive deficits compared to Alzheimer's disease. (16082076)
2005
43
Posterior cortical atrophy: a review of the literature. (15788276)
2004
44
Simultanagnosia in posterior cortical atrophy. (11796782)
2002
45
Visuospatial deficits with preserved reading ability in a patient with posterior cortical atrophy. (11721864)
2001
46
The evolution of alexia and simultanagnosia in posterior cortical atrophy. (9652488)
1998
47
Cerebellar ataxia, dementia, pyramidal signs, cortical cataract of the posterior pole and a raised IgG index in a patient with a sporadic form of olivopontocerebellar atrophy. (9213052)
1997
48
Progressive visual agnosia with posterior cortical atrophy. (8836594)
1996
49
Alzheimer's disease in a patient with posterior cortical atrophy. (1783928)
1991
50
Posterior cortical atrophy. (3390033)
1988

Genetic Variations for Posterior Cortical Atrophy

Expression for genes affiliated with Posterior Cortical Atrophy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Posterior Cortical Atrophy

Search GEO for disease gene expression data for Posterior Cortical Atrophy.

Pathways for genes affiliated with Posterior Cortical Atrophy

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology, 52QIAGEN
See all sources

Pathways related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1MAPT, APOE
29.1MAPT, APOE
39.1MAPT, APOE
49.1MAPT, APOE

Compounds for genes affiliated with Posterior Cortical Atrophy

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB, 29IUPHAR
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Compounds related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1thioflavine s459.5MAPT, APOE
2tacrine45 1110.5MAPT, APOE
3donepezil45 11 2411.5MAPT, APOE
4galantamine45 50 1111.5APOE, MAPT
5formate459.5MAPT, APOE
6guanidine45 11 2411.5APOE, MAPT
7spec-t459.5APOE, MAPT
8vitamin b12459.5MAPT, APOE
94-hydroxynonenal45 2410.5MAPT, APOE
10chloroquine45 2 50 29 1113.5APOE, MAPT
11lactacystin459.4MAPT, APOE
12kainate45 2910.4MAPT, APOE
13sodium dodecylsulfate459.4MAPT, APOE
14folate459.4APOE, MAPT
15nicotine45 50 29 1112.4MAPT, APOE
16valine459.4MAPT, APOE
17n acetylcysteine459.4MAPT, APOE
18nmda45 2910.4APOE, MAPT
19acetylcholine45 50 29 11 2413.3MAPT, APOE
20actinomycin d459.3MAPT, APOE
21paraffin459.3APOE, MAPT
22glutamine459.2MAPT, APOE
23dopamine45 29 11 2412.2MAPT, APOE
24creatinine459.1APOE, MAPT
25cycloheximide459.1MAPT, APOE
26aspartate459.0MAPT, APOE
27heparin45 29 11 2411.8MAPT, APOE

GO Terms for genes affiliated with Posterior Cortical Atrophy

Sources:
16Gene Ontology
See all sources

Biological processes related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of axon extensionGO:0457739.1MAPT, APOE

Molecular functions related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.1MAPT, APOE

Products for genes affiliated with Posterior Cortical Atrophy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Posterior Cortical Atrophy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet