PCA
MCID: PST086
MIFTS: 32

Posterior Cortical Atrophy (PCA) malady

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Posterior Cortical Atrophy

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Sources:
31ICD10 via Orphanet, 54Orphanet
See all MalaCards sources

Aliases & Descriptions for Posterior Cortical Atrophy:

Name: Posterior Cortical Atrophy 54
Biparietal Alzheimer Disease 54
 
Benson Syndrome 54
Pca 54

Characteristics:

Orphanet epidemiological data:

54
biparietal alzheimer disease:
Age of onset: Adult; Age of death: adult

Classifications:



External Ids:

Orphanet54 ORPHA54247
ICD10 via Orphanet31 G31.1

Summaries for Posterior Cortical Atrophy

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Wikipedia:71 Posterior cortical atrophy (PCA), also called Benson\'s syndrome, is a form of dementia which is usually... more...

MalaCards based summary: Posterior Cortical Atrophy, also known as biparietal alzheimer disease, is related to amyloidosis, primary localized cutaneous, 1 and choanal atresia, posterior. An important gene associated with Posterior Cortical Atrophy is APOE (Apolipoprotein E), and among its related pathways are Neuroscience and Reelin Pathway (Cajal-Retzius cells). Affiliated tissues include cortex, brain and temporal lobe, and related mouse phenotype taste/olfaction.

Related Diseases for Posterior Cortical Atrophy

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Graphical network of the top 20 diseases related to Posterior Cortical Atrophy:



Diseases related to posterior cortical atrophy

Symptoms & Phenotypes for Posterior Cortical Atrophy

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MGI Mouse Phenotypes related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1APOE, MAPT

Drugs & Therapeutics for Posterior Cortical Atrophy

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Drugs for Posterior Cortical Atrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Cysteamineapproved, investigationalPhase 42760-23-16058
Synonyms:
(2-Mercaptoethyl)amine
(Mercaptoethyl)ammonium toluene-p-sulphonate
.beta.-Mercaptoethylamine
1-Amino-2-mercaptoethylamine
139720-70-0
156-57-0 (hydrochloride)
16904-32-8 (di-hydrochloride)
2-AMINO-ETHANETHIOL
2-AMINO-ethanethiol
2-Amino-1-ethanethiol
2-Aminoethanethiol
2-Aminoethyl mercaptan
2-Mercaptoethanamine
2-Mercaptoethylamine
2-Mercaptoethylamine, polymer-bound
27761-19-9 (tartrate (1:1))
2DFDA1F8-7010-4225-8280-AB1C4C43F546
30070_FLUKA
30070_SIGMA
3037-04-5
3037-04-5 (tosylate)
42954-15-4 (hydrobromide)
60-23-1
60-23-1 (Parent)
641022_ALDRICH
93965-19-6 (maleate (1:1))
A0648
AC1L1LPL
AC1Q54NL
AKOS003793343
Aminoethyl mercaptan
Becaptan
C-9500
C01678
C2H7NS
CASH
CCRIS 3083
CHEBI:17141
CHEMBL602
CID6058
CYSTEAMINE
Cisteamina
Cisteamina [Italian]
Cystavision
Cysteamide
Cysteamin
Cysteamine
Cysteamine (USAN)
Cysteamine [USAN:BAN]
Cysteamine bitartate
Cysteamine hydrochloride
Cysteaminium
Cysteinamine
D03634
DB00847
Decarboxycysteine
DivK1c_006750
 
EINECS 200-463-0
EINECS 221-235-7
Ethanethiolamine
HSDB 7353
KBio1_001694
KBio2_002235
KBio2_004803
KBio2_007371
KBioSS_002235
L 1573
L-1573
LS-65761
Lambraten
Lambratene
Lopac-M-6500
M9768_ALDRICH
M9768_SIGMA
MEA
MEA (mercaptan)
Mecramine
Mercamin
Mercamine
Mercaptamin
Mercaptamina
Mercaptamina [INN-Spanish]
Mercaptamine
Mercaptamine (INN)
Mercaptaminum
Mercaptaminum [INN-Latin]
Mercaptoethylamine
Merkamin
MolPort-001-662-635
NCGC00015691-01
NCGC00015691-04
NCGC00162236-01
NCI60_002000
NSC 647528
NSC647528
Riacon
STK315355
SpecPlus_000654
Spectrum_001755
Thioethanolamine
UNII-5UX2SD1KE2
WR 347
b-Aminoethanethiol
b-Aminoethylthiol
b-Mercaptoethylamine
beta-Aminoethanethiol
beta-Aminoethylthiol
beta-MEA
beta-Mercaptoethylamine
bmse000388
cysteamine bitartrate
nchembio.315-comp1
nchembio.316-comp1
β-MEA
β-aminoethylthiol
2
Acetylcysteineapproved, investigationalPhase 4330616-91-112035
Synonyms:
(2R)-2-acetylamino-3-sulfanylpropanoic acid
(R)-2-acetylamino-3-mercaptopropanoic acid
(R)-mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
Fluprowit
 
L-Acetylcysteine
L-acetylcysteine
L-α-acetamido-β-mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetyl-L-(+)-cysteine
N-acetyl-L-cysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
3
Cholineapproved, nutraceuticalPhase 415462-49-7305
Synonyms:
(2-Hydroxyethyl)trimethyl ammonium
(2-Hydroxyethyl)trimethylammonium
(beta-hydroxyethyl)trimethylammonium
2-Hydroxy-N,N,N-trimethyl-ethanaminium
2-Hydroxy-N,N,N-trimethylethanaminium
Bilineurine
Biocolina
Biocoline
Choline
Choline cation
 
Choline ion
Cholinum
Hepacholine
Hormocline
Lipotril
N,N,N-Trimethylethanol-ammonium
N,N,N-Trimethylethanolammonium
N,N,N-trimethylethanol-ammonium
N-trimethylethanolamine
Neocolina
Paresan
trimethylethanolamine
4N-monoacetylcystinePhase 4330
5Respiratory System AgentsPhase 44997
6Protective AgentsPhase 47443
7ExpectorantsPhase 4404
8Antiviral AgentsPhase 49967
9Anti-Infective AgentsPhase 422062
10AntidotesPhase 41071
11AntioxidantsPhase 43050
12Nootropic AgentsPhase 4716
13Cytidine Diphosphate CholinePhase 430
14
CorticosteronePhase 11150-22-65753
Synonyms:
11,21-Dihydroxypregn-4-ene-3,20-dione
11,21-Dihydroxyprogesterone
11-Hydroxycorticoaldosterone
 
17-Deoxycortisol
4-Pregnene-11 Corticosteron
Corticosterone
Kendall'S compound B
Reichstein'S substance H

Interventional clinical trials:

(show all 12)
idNameStatusNCT IDPhase
1Cystagon to Treat Infantile Neuronal Ceroid LipofuscinosisCompletedNCT00028262Phase 4
2Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)RecruitingNCT03046693Phase 4
3Tau Brain Imaging in Typical and Atypical Alzheimer's Disease (AD)RecruitingNCT03022968Phase 2
4Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical ADCompletedNCT01723553Phase 1
5Buccal Fat Pad Derived Stem Cells With Cortical Tenting in Posterior Mandible ReconstructionRecruitingNCT02745366Phase 1
6Influence of Age on Amyloid Load in Alzheimer's Disease and in Atypical Focal Cortical Alzheimer's DiseaseCompletedNCT01095744
7PET Imaging in Chronic Traumatic EncephalopathyCompletedNCT02211820
8Emotional Communication Disorders in Cerebellar DiseaseCompletedNCT02106819
9Molecular and Structural Imaging in Atypical Alzheimer's Disease: A Longitudinal StudyRecruitingNCT02740634
10Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural NetworksRecruitingNCT03153371
11Tau Imaging in Young Onset DementiaActive, not recruitingNCT02289118
12Plasticity of Grey and White Matter in Response to Motor Skill Training in Healthy Individuals and Those With Spinal Cord InjuryActive, not recruitingNCT02148887

Search NIH Clinical Center for Posterior Cortical Atrophy

Genetic Tests for Posterior Cortical Atrophy

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Anatomical Context for Posterior Cortical Atrophy

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MalaCards organs/tissues related to Posterior Cortical Atrophy:

36
Cortex, Brain, Temporal lobe, Testes, Endothelial

Publications for Posterior Cortical Atrophy

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Articles related to Posterior Cortical Atrophy:

(show top 50)    (show all 168)
idTitleAuthorsYear
1
The oral spelling profile of posterior cortical atrophy and the nature of the graphemic representation. (27913156)
2017
2
Progression of oculomotor deficit in a patient with posterior cortical atrophy. (27816183)
2017
3
A novel use of arterial spin labelling MRI to demonstrate focal hypoperfusion in individuals with posterior cortical atrophy: a multimodal imaging study. (26733599)
2016
4
Posterior cortical atrophy as a primary clinical phenotype of corticobasal syndrome with a progranulin gene rs5848 TT genotype. (26852323)
2016
5
Neuro-cognitive mechanisms of simultanagnosia in patients with posterior cortical atrophy. (27702740)
2016
6
Memory Impairment at Initial Clinical Presentation in Posterior Cortical Atrophy. (27128371)
2016
7
Functional Connectivity of Ventral and Dorsal Visual Streams in Posterior Cortical Atrophy. (26923019)
2016
8
18F-FDG PET in Posterior Cortical Atrophy and Dementia with Lewy Bodies. (27688479)
2016
9
Can patients without early, prominent visual deficits still be diagnosed of posterior cortical atrophy? (27423559)
2016
10
Clinical and neuroimaging differences between posterior cortical atrophy and typical amnestic Alzheimer's disease patients at an early disease stage. (27377199)
2016
11
Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease. (26993346)
2016
12
Saccades abnormalities in posterior cortical atrophy - A case report. (28063320)
2016
13
Non-pharmacological intervention for posterior cortical atrophy. (27574605)
2016
14
Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease. (28068564)
2016
15
Effect of age at onset on cortical thickness and cognition in posterior cortical atrophy. (27318138)
2016
16
Neuropsychiatric Symptoms in Posterior Cortical Atrophy and Alzheimer Disease. (26404166)
2015
17
Evaluating pathogenic dementia variants in posterior cortical atrophy. (26507310)
2015
18
Posterior cortical atrophy: an atypical variant of Alzheimer disease. (25998111)
2015
19
3D Shape Perception in Posterior Cortical Atrophy: A Visual Neuroscience Perspective. (26377458)
2015
20
Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy. (26480294)
2015
21
Functional neural substrates of posterior cortical atrophy patients. (25976028)
2015
22
Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy. (25895507)
2015
23
Derailed dementia: Alzheimer's disease versus posterior cortical atrophy. (25688631)
2015
24
Reduced modulation of scanpaths in response to task demands in posterior cortical atrophy. (25596316)
2015
25
Posterior Cortical Atrophy: A Case Report of a 6-Year Natural Progression. (26704219)
2015
26
A Pilot Study on Clinical and Neuroimaging Characteristics of Chinese Posterior Cortical Atrophy: Comparison with Typical Alzheimer's Disease. (26267071)
2015
27
Left temporal lobe epilepsy revealing left posterior cortical atrophy due to Alzheimer's disease. (25589715)
2015
28
Facilitating text reading in posterior cortical atrophy. (26138948)
2015
29
Clinical, FDG and amyloid PET imaging in posterior cortical atrophy. (25862483)
2015
30
Differential hippocampal shapes in posterior cortical atrophy patients: A comparison with control and typical AD subjects. (26461053)
2015
31
Posterior cortical atrophy as an extreme phenotype of GRN mutations. (25546130)
2015
32
Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy. (25448043)
2015
33
Oculomotor abnormalities in posterior cortical atrophy: are they different from those in Alzheimer's disease after all? (26106096)
2015
34
Posterior Cortical Atrophy Presenting with Superior Arcuate Field Defect. (26417467)
2015
35
Treatment of a patient with posterior cortical atrophy (PCA) with chiropractic manipulation and Dynamic Neuromuscular Stabilization (DNS): A case report. (25729084)
2015
36
Visual field defect as an uncommon presentation of posterior cortical atrophy. (25327905)
2014
37
(Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy. (24841985)
2014
38
Hiding in plain sight: a closer look at posterior cortical atrophy. (25216669)
2014
39
Pronounced Impairment of Everyday Skills and Self-Care in Posterior Cortical Atrophy. (25096622)
2014
40
Counting or chunking? Mathematical and heuristic abilities in patients with corticobasal syndrome and posterior cortical atrophy. (25278132)
2014
41
Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD. (24670887)
2014
42
Syndrome-Specific Patterns of Regional Cerebral Glucose Metabolism in Posterior Cortical Atrophy in Comparison to Dementia with Lewy Bodies and Alzheimer's Disease-A [F-18]-Fdg Pet Study. (24593796)
2014
43
Quantitative regional validation of the visual rating scale for posterior cortical atrophy. (24092044)
2014
44
First Report of PSEN2 Mutation Presenting as Posterior Cortical Atrophy. (25010293)
2014
45
Further evidence about the crucial role of CSF biomarkers in diagnosis of posterior cortical atrophy. (24487699)
2014
46
Differential processing of natural scenes in posterior cortical atrophy and in Alzheimer's disease, as measured with a saccade choice task. (25120440)
2014
47
Diagnosis of posterior cortical atrophy delayed by coexisting Fuchs' Endothelial Corneal Dystrophy. (24667904)
2014
48
Phenotypical variation in Alzheimer's disease: insights from posterior cortical atrophy. (25239627)
2014
49
Brain Changes within the Visuo-Spatial Attentional Network in Posterior Cortical Atrophy. (25114070)
2014
50
The Neuropsychiatric Profile of Posterior Cortical Atrophy. (25330926)
2014

Variations for Posterior Cortical Atrophy

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Expression for genes affiliated with Posterior Cortical Atrophy

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Search GEO for disease gene expression data for Posterior Cortical Atrophy.

Pathways for genes affiliated with Posterior Cortical Atrophy

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Pathways related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.1APOE, MAPT
29.1APOE, MAPT
39.1APOE, MAPT

GO Terms for genes affiliated with Posterior Cortical Atrophy

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Cellular components related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:00304259.8APOE, MAPT
2neuronal cell bodyGO:00430259.1APOE, MAPT

Molecular functions related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:00718139.1APOE, MAPT

Sources for Posterior Cortical Atrophy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet