PCA
MCID: PST086
MIFTS: 28

Posterior Cortical Atrophy (PCA) malady

Neuronal diseases category

Summaries for Posterior Cortical Atrophy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Posterior cortical atrophy (PCA), also called Benson\'s syndrome, is a form of dementia which is usually... more...

MalaCards: Posterior Cortical Atrophy, also known as biparietal alzheimer disease, is related to lewy body dementia and aphasia. An important gene associated with Posterior Cortical Atrophy is MAPT (microtubule-associated protein tau), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Neuroscience. The compounds thioflavine s and tacrine have been mentioned in the context of this disorder. Affiliated tissues include cortex and brain, and related mouse phenotypes are other and taste/olfaction.

Aliases & Classifications for Posterior Cortical Atrophy

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Sources:
48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
biparietal alzheimer disease:
Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

posterior cortical atrophy 48
biparietal alzheimer disease 48
benson syndrome 48
pca 48


External Ids:

ICD10 via Orphanet26 G31.1

Related Diseases for Posterior Cortical Atrophy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Posterior Cortical Atrophy:



Diseases related to posterior cortical atrophy

Clinical Features for Posterior Cortical Atrophy

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Drugs & Therapeutics for Posterior Cortical Atrophy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Posterior Cortical Atrophy

Search NIH Clinical Center for Posterior Cortical Atrophy

Search CenterWatch for Posterior Cortical Atrophy

Genetic Tests for Posterior Cortical Atrophy

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Anatomical Context for Posterior Cortical Atrophy

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32MalaCards
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MalaCards organs/tissues related to Posterior Cortical Atrophy:

32
Cortex, Brain

Animal Models for Posterior Cortical Atrophy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Posterior Cortical Atrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1MAPT, APOE
2MP:00053948.8MAPT, APOE

Publications for Posterior Cortical Atrophy

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Genetic Variations for Posterior Cortical Atrophy

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Expression for genes affiliated with Posterior Cortical Atrophy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Posterior Cortical Atrophy

Search GEO for disease gene expression data for Posterior Cortical Atrophy.

Pathways for genes affiliated with Posterior Cortical Atrophy

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Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1MAPT, APOE
29.1MAPT, APOE
39.1MAPT, APOE
49.1MAPT, APOE

Compounds for genes affiliated with Posterior Cortical Atrophy

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB, 28IUPHAR
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Compounds related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1thioflavine s449.5MAPT, APOE
2tacrine44 1110.5MAPT, APOE
3donepezil44 11 2411.5APOE, MAPT
4galantamine44 49 1111.5MAPT, APOE
5formate449.5MAPT, APOE
6guanidine44 11 2411.5MAPT, APOE
7spec-t449.5APOE, MAPT
8vitamin b12449.5MAPT, APOE
94-hydroxynonenal44 2410.5MAPT, APOE
10chloroquine44 2 49 28 1113.5MAPT, APOE
11lactacystin449.4MAPT, APOE
12kainate44 2810.4APOE, MAPT
13sodium dodecylsulfate449.4MAPT, APOE
14folate449.4APOE, MAPT
15nicotine44 49 28 1112.4APOE, MAPT
16valine449.4APOE, MAPT
17n acetylcysteine449.4MAPT, APOE
18nmda44 2810.4APOE, MAPT
19acetylcholine44 49 28 11 2413.3MAPT, APOE
20actinomycin d449.3APOE, MAPT
21paraffin449.3MAPT, APOE
22glutamine449.2MAPT, APOE
23dopamine44 28 11 2412.2APOE, MAPT
24creatinine449.1MAPT, APOE
25cycloheximide449.1MAPT, APOE
26aspartate449.0APOE, MAPT
27heparin44 28 11 2411.8APOE, MAPT

GO Terms for genes affiliated with Posterior Cortical Atrophy

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Sources:
16Gene Ontology
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Biological processes related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of axon extensionGO:0457739.1MAPT, APOE

Molecular functions related to Posterior Cortical Atrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.1MAPT, APOE

Products for genes affiliated with Posterior Cortical Atrophy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Posterior Cortical Atrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet