MCID: PST086
MIFTS: 37

Posterior Cortical Atrophy malady

Neuronal diseases, Rare diseases categories

Aliases & Classifications for Posterior Cortical Atrophy

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Sources:
48Orphanet, 26ICD10 via Orphanet
See all sources

Aliases & Descriptions for Posterior Cortical Atrophy:

Name: Posterior Cortical Atrophy 48
Biparietal Alzheimer Disease 48
 
Benson Syndrome 48
Pca 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
biparietal alzheimer disease:
Age of onset: Adult; Age of death: adult


External Ids:

Orphanet48 54247
ICD10 via Orphanet26 G31.1

Summaries for Posterior Cortical Atrophy

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Wikipedia:64 Posterior cortical atrophy (PCA), also called Benson\'s syndrome, is a form of dementia which is usually... more...

MalaCards based summary: Posterior Cortical Atrophy, also known as biparietal alzheimer disease, is related to dementia and alzheimer disease, and has symptoms including oculomotor apraxia/dyspraxia, alexia/agraphia/writing/reading troubles and visual/auditory/tactile agnosia/propopagnosia/simultagnosia. An important gene associated with Posterior Cortical Atrophy is MAPT (microtubule-associated protein tau), and among its related pathways are Neuroscience and Alzheimer's disease. The compounds thioflavine s and tacrine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and testes, and related mouse phenotypes are other and taste/olfaction.

Related Diseases for Posterior Cortical Atrophy

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Graphical network of the top 20 diseases related to Posterior Cortical Atrophy:



Diseases related to posterior cortical atrophy

Symptoms for Posterior Cortical Atrophy

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Symptoms:

 48 (show all 8)
  • oculomotor apraxia/dyspraxia
  • alexia/agraphia/writing/reading troubles
  • visual/auditory/tactile agnosia/propopagnosia/simultagnosia
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • extrapyramidal syndrome
  • troubles of memory/amnesia/hypermnesia
  • diplopia/double vision
  • psychic/psychomotor regression/dementia/intellectual decline

Drugs & Therapeutics for Posterior Cortical Atrophy

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Drug clinical trials:

Search ClinicalTrials for Posterior Cortical Atrophy

Search NIH Clinical Center for Posterior Cortical Atrophy

Genetic Tests for Posterior Cortical Atrophy

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Anatomical Context for Posterior Cortical Atrophy

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MalaCards organs/tissues related to Posterior Cortical Atrophy:

31
Cortex, Brain, Testes, Endothelial, Temporal lobe

Animal Models for Posterior Cortical Atrophy or affiliated genes

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MGI Mouse Phenotypes related to Posterior Cortical Atrophy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1MAPT, APOE
2MP:00053948.8MAPT, APOE

Publications for Posterior Cortical Atrophy

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Articles related to Posterior Cortical Atrophy:

(show top 50)    (show all 139)
idTitleAuthorsYear
1
Derailed dementia: Alzheimer's disease versus posterior cortical atrophy. (25688631)
2015
2
Posterior cortical atrophy as an extreme phenotype of GRN mutations. (25546130)
2015
3
(Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy. (24841985)
2014
4
Brain Changes within the Visuo-Spatial Attentional Network in Posterior Cortical Atrophy. (25114070)
2014
5
The Pattern of Brain Amyloid Load in Posterior Cortical Atrophy Using (18)F-AV45: Is Amyloid the Principal Actor in the Disease? (25538727)
2014
6
Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD. (24670887)
2014
7
The progression of posterior cortical atrophy to corticobasal syndrome: lumping or splitting neurodegenerative diseases? (25009764)
2014
8
Hiding in plain sight: a closer look at posterior cortical atrophy. (25216669)
2014
9
Upside-down Drawing in Posterior Cortical Atrophy. (25373818)
2014
10
The Neuropsychiatric Profile of Posterior Cortical Atrophy. (25330926)
2014
11
Visual field defect as an uncommon presentation of posterior cortical atrophy. (25327905)
2014
12
Shining a light on posterior cortical atrophy. (23274153)
2013
13
Olfactory impairment in posterior cortical atrophy. (23435114)
2013
14
Visual impairment and posterior cortical atrophy preceding rapid progressive dementia. (23283613)
2013
15
Posterior cortical atrophy: an investigation of scan paths generated during face matching tasks. (23825453)
2013
16
Logopenic syndrome in posterior cortical atrophy. (23007194)
2013
17
Towards an earlier diagnosis of Alzheimer's disease presenting with visuospatial disorders (posterior cortical atrophy). (24035594)
2013
18
Aphasia with left occipitotemporal hypometabolism: a novel presentation of posterior cortical atrophy? (23850398)
2013
19
Ophthalmic impairment or higher-order visual deficit? Posterior cortical atrophy: a case report. (23373584)
2012
20
Visuospatial deficits in posterior cortical atrophy: structural and functional correlates. (22645257)
2012
21
Brain networks in posterior cortical atrophy: a single case tractography study and literature review. (22099855)
2012
22
Long-standing prion dementia manifesting as posterior cortical atrophy. (21959360)
2012
23
Huntington's disease presenting as posterior cortical atrophy. (21625777)
2011
24
Posterior cortical atrophy: an exemplar for renovating diagnostic formulation in neuropsychiatry. (21497228)
2011
25
The evolution of alexia in two cases of posterior cortical atrophy. (21876262)
2011
26
Abnormal visual phenomena in posterior cortical atrophy. (20818540)
2011
27
Similar amyloid-I^ burden in posterior cortical atrophy and Alzheimer's disease. (21705422)
2011
28
Posterior cortical atrophy with prominent alexia without agraphia in a Tourette syndrome. (21912890)
2011
29
Presenile dementia diagnosed as posterior cortical atrophy. (21951958)
2011
30
Basic visual function and cortical thickness patterns in posterior cortical atrophy. (21310781)
2011
31
Visuo-spatial imagery impairment in posterior cortical atrophy: a cognitive and SPECT study. (21606573)
2011
32
Cognitive rehabilitation in posterior cortical atrophy. (20306369)
2010
33
Visual impairments in dementia with Lewy bodies and posterior cortical atrophy. (20063945)
2010
34
Processing of wh-questions in a case of posterior cortical atrophy. (21271923)
2009
35
Pattern and progression of white-matter changes in a case of posterior cortical atrophy using diffusion tensor imaging. (19289480)
2009
36
The role of neuropsychology in distinguishing the posterior cortical atrophy syndrome and Alzheimer's disease. (19542605)
2009
37
Use of the Visual Object and Space Perception (VOSP) test battery in two cases of posterior cortical atrophy. (19031338)
2008
38
Atrophy and decreased activation of fronto-parietal attention areas contribute to higher visual dysfunction in posterior cortical atrophy. (18945600)
2008
39
Posterior cortical atrophy: a rare form of dementia with in vivo evidence of amyloid-beta accumulation. (18997288)
2008
40
Foveal crowding in posterior cortical atrophy: a specific early-visual-processing deficit affecting word reading. (18161498)
2007
41
Exploded drawing in posterior cortical atrophy. (17130426)
2006
42
Visual hallucinations in posterior cortical atrophy. (17030659)
2006
43
What are we seeing? Is posterior cortical atrophy just Alzheimer disease? (16476924)
2006
44
Posterior cortical atrophy: a review of the literature. (15788276)
2004
45
Cortical sensory loss in a patient with posterior cortical atrophy: a case report. (15849159)
2004
46
Dementia following posterior cortical atrophy--a descriptive clinical case report. (15374033)
2001
47
Alexia and agraphia in posterior cortical atrophy. (9118197)
1997
48
Posterior cortical atrophy: neuropathological correlations. (8859056)
1996
49
Posterior cortical atrophy in Alzheimer's disease: analysis of a new case and re-evaluation of a historical report. (8213079)
1993
50
Alzheimer's disease in a patient with posterior cortical atrophy. (1783928)
1991

Variations for Posterior Cortical Atrophy

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Expression for genes affiliated with Posterior Cortical Atrophy

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Search GEO for disease gene expression data for Posterior Cortical Atrophy.

Pathways for genes affiliated with Posterior Cortical Atrophy

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Pathways related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1MAPT, APOE
2
Show member pathways
Alzheimers Disease36
9.1MAPT, APOE
39.1MAPT, APOE
49.1MAPT, APOE

Compounds for genes affiliated with Posterior Cortical Atrophy

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Compounds related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

(show all 33)
idCompoundScoreTop Affiliating Genes
1thioflavine s449.5APOE, MAPT
2tacrine44 1110.5MAPT, APOE
3donepezil44 50 24 1112.5APOE, MAPT
4galantamine44 50 1111.5MAPT, APOE
5formate449.5MAPT, APOE
6guanidine44 24 1111.5APOE, MAPT
7spec-t449.5APOE, MAPT
8vitamin b12449.5MAPT, APOE
94-hydroxynonenal44 2410.5MAPT, APOE
10chloroquine44 1 50 28 1113.5MAPT, APOE
11lactacystin449.5APOE, MAPT
12kainate44 2810.5MAPT, APOE
13sodium dodecylsulfate449.5APOE, MAPT
14folate449.5MAPT, APOE
15nicotine44 28 50 1112.5MAPT, APOE
16valine449.5APOE, MAPT
17n acetylcysteine449.4APOE, MAPT
18nmda44 2810.4APOE, MAPT
19acetylcholine44 50 28 24 1113.4APOE, MAPT
20actinomycin d449.4MAPT, APOE
21paraffin449.4MAPT, APOE
22cyclosporin a44 28 6011.4MAPT, APOE
23glutamine449.4APOE, MAPT
24dopamine44 28 24 1112.4APOE, MAPT
25creatinine449.3APOE, MAPT
26aspartate449.3APOE, MAPT
27heparin44 28 24 1112.3MAPT, APOE
28cycloheximide449.2APOE, MAPT
29h2o2449.2APOE, MAPT
30testosterone44 60 24 1112.1APOE, MAPT
31alanine449.1APOE, MAPT
32arginine449.0APOE, MAPT
33glutamate448.8APOE, MAPT

GO Terms for genes affiliated with Posterior Cortical Atrophy

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Biological processes related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of axon extensionGO:00457739.1MAPT, APOE

Molecular functions related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:00718139.1MAPT, APOE

Sources for Posterior Cortical Atrophy

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet