MCID: PST086
MIFTS: 30

Posterior Cortical Atrophy

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Posterior Cortical Atrophy

MalaCards integrated aliases for Posterior Cortical Atrophy:

Name: Posterior Cortical Atrophy 56
Biparietal Alzheimer Disease 56
Benson Syndrome 56
Pca 56

Characteristics:

Orphanet epidemiological data:

56
posterior cortical atrophy
Age of onset: Adult; Age of death: adult;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA54247
ICD10 via Orphanet 34 G31.1

Summaries for Posterior Cortical Atrophy

MalaCards based summary : Posterior Cortical Atrophy, also known as biparietal alzheimer disease, is related to amyloidosis, primary localized cutaneous, 1 and choanal atresia, posterior. An important gene associated with Posterior Cortical Atrophy is APOE (Apolipoprotein E), and among its related pathways/superpathways are Neuroscience and Reelin Pathway (Cajal-Retzius cells). The drug Corticosterone has been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and temporal lobe, and related phenotype is taste/olfaction.

Wikipedia : 72 Posterior cortical atrophy (PCA), also called Benson\'s syndrome, is a form of dementia which is usually... more...

Related Diseases for Posterior Cortical Atrophy

Diseases related to Posterior Cortical Atrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
id Related Disease Score Top Affiliating Genes
1 amyloidosis, primary localized cutaneous, 1 10.8
2 choanal atresia, posterior 10.8
3 primary cutaneous amyloidosis 10.8
4 prostate cancer 10.3
5 prostatitis 10.3
6 dementia 10.3
7 alzheimer disease 10.1
8 alexia 10.0
9 simultanagnosia 9.9
10 acquired purpura fulminans 9.9 APOE MAPT
11 moyamoya disease 9.9
12 seow najjar syndrome 9.9 APOE MAPT
13 pulmonary systemic sclerosis 9.9 APOE MAPT
14 bladder cancer, childhood 9.8 APOE MAPT
15 limited scleroderma 9.8 APOE MAPT
16 meckel syndrome 10 9.8 APOE MAPT
17 supranuclear palsy, progressive atypical 9.8 APOE MAPT
18 agraphia 9.8
19 agnosia 9.8
20 nosophobia 9.8 APOE MAPT
21 auditory agnosia 9.8 APOE MAPT
22 carotid body cancer 9.8 APOE MAPT
23 parkinson disease 1 9.8 APOE MAPT
24 tendinopathy 9.8 APOE MAPT
25 personality disorder 9.7 APOE MAPT
26 cardiomyopathy, dilated, 1u 9.7 APOE MAPT
27 allergic bronchopulmonary aspergillosis, familial 9.7 APOE MAPT
28 prion disease with protracted course 9.7 APOE MAPT
29 temporal lobe epilepsy 9.7
30 aphasia 9.7
31 visual agnosia 9.7
32 parametritis 9.7
33 epilepsy 9.7
34 anxiety disorder 9.7
35 corneal dystrophy 9.7
36 cerebritis 9.7
37 dysgraphia 9.7
38 thyroiditis 9.7
39 corticobasal degeneration 9.7
40 semantic dementia 9.7
41 endotheliitis 9.7
42 prostate carcinoma in situ 9.7 APOE MAPT
43 pick disease 9.6 APOE MAPT
44 hepatic angiomyolipoma 9.6 APOE MAPT
45 ichthyosis lamellar 1 9.5 APOE MAPT
46 hypersensitivity syndrome, carbamazepine-induced 9.5 APOE MAPT
47 eumycotic mycetoma 9.4 APOE MAPT
48 parkinson disease, late-onset 9.2 APOE MAPT

Graphical network of the top 20 diseases related to Posterior Cortical Atrophy:



Diseases related to Posterior Cortical Atrophy

Symptoms & Phenotypes for Posterior Cortical Atrophy

MGI Mouse Phenotypes related to Posterior Cortical Atrophy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 APOE MAPT

Drugs & Therapeutics for Posterior Cortical Atrophy

Drugs for Posterior Cortical Atrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Corticosterone Experimental Phase 1 50-22-6 5753

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Tau Brain Imaging in Typical and Atypical Alzheimer's Disease (AD) Recruiting NCT03022968 Phase 2 [18F]T807 PET
2 Amyloid-related Imaging Abnormalities (Microbleeds) in Atypical AD Completed NCT01723553 Phase 1 C-11 PiB
3 Influence of Age on Amyloid Load in Alzheimer's Disease and in Atypical Focal Cortical Alzheimer's Disease Completed NCT01095744
4 Molecular and Structural Imaging in Atypical Alzheimer's Disease: A Longitudinal Study Recruiting NCT02740634 F-18 AV 1451;C-11 PiB
5 Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks Recruiting NCT03153371
6 Tau Imaging in Young Onset Dementia Active, not recruiting NCT02289118 [18F]-T807 imaging tracer

Search NIH Clinical Center for Posterior Cortical Atrophy

Genetic Tests for Posterior Cortical Atrophy

Anatomical Context for Posterior Cortical Atrophy

MalaCards organs/tissues related to Posterior Cortical Atrophy:

39
Cortex, Brain, Temporal Lobe, Endothelial, Thyroid, Testes

Publications for Posterior Cortical Atrophy

Articles related to Posterior Cortical Atrophy:

(show top 50) (show all 179)
id Title Authors Year
1
Semantic word category processing in semantic dementia and posterior cortical atrophy. ( 28624681 )
2017
2
Lateralized occipital degeneration in posterior cortical atrophy predicts visual field deficits. ( 28180083 )
2017
3
Consensus classification of posterior cortical atrophy. ( 28259709 )
2017
4
F-18 FDG and F-18 Tau PET in posterior cortical atrophy. ( 28584971 )
2017
5
Tau-PET Binding Distinguishes Patients With Early-stage Posterior Cortical Atrophy From Amnestic Alzheimer Disease Dementia. ( 28394771 )
2017
6
The Nature and Natural History of Posterior Cortical Atrophy Syndrome: A Variant of Early-onset Alzheimer Disease. ( 28796011 )
2017
7
The oral spelling profile of posterior cortical atrophy and the nature of the graphemic representation. ( 27913156 )
2017
8
A case of posterior cortical atrophy with vertical neglect. ( 28387593 )
2017
9
Homonymous Hemianopsia Due to Posterior Cortical Atrophy. ( 28512507 )
2017
10
Homonymous hemianopia as the first sign of posterior cortical atrophy. ( 28131221 )
2017
11
Association between low thyroid-stimulating hormone, posterior cortical atrophy and nitro-oxidative stress in elderly patients with cognitive dysfunction. ( 28883858 )
2017
12
Progression of oculomotor deficit in a patient with posterior cortical atrophy. ( 27816183 )
2017
13
Visual Dysfunction in Posterior Cortical Atrophy. ( 28861031 )
2017
14
Neuro-cognitive mechanisms of simultanagnosia in patients with posterior cortical atrophy. ( 27702740 )
2016
15
A novel use of arterial spin labelling MRI to demonstrate focal hypoperfusion in individuals with posterior cortical atrophy: a multimodal imaging study. ( 26733599 )
2016
16
Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease. ( 26993346 )
2016
17
18F-FDG PET in Posterior Cortical Atrophy and Dementia with Lewy Bodies. ( 27688479 )
2016
18
Memory Impairment at Initial Clinical Presentation in Posterior Cortical Atrophy. ( 27128371 )
2016
19
Functional Connectivity of Ventral and Dorsal Visual Streams in Posterior Cortical Atrophy. ( 26923019 )
2016
20
Effect of age at onset on cortical thickness and cognition in posterior cortical atrophy. ( 27318138 )
2016
21
Clinical and neuroimaging differences between posterior cortical atrophy and typical amnestic Alzheimer's disease patients at an early disease stage. ( 27377199 )
2016
22
Saccades abnormalities in posterior cortical atrophy - A case report. ( 28063320 )
2016
23
Posterior cortical atrophy as a primary clinical phenotype of corticobasal syndrome with a progranulin gene rs5848 TT genotype. ( 26852323 )
2016
24
Can patients without early, prominent visual deficits still be diagnosed of posterior cortical atrophy? ( 27423559 )
2016
25
Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease. ( 28068564 )
2016
26
Non-pharmacological intervention for posterior cortical atrophy. ( 27574605 )
2016
27
Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy. ( 25448043 )
2015
28
Differential hippocampal shapes in posterior cortical atrophy patients: A comparison with control and typical AD subjects. ( 26461053 )
2015
29
A Pilot Study on Clinical and Neuroimaging Characteristics of Chinese Posterior Cortical Atrophy: Comparison with Typical Alzheimer's Disease. ( 26267071 )
2015
30
Posterior Cortical Atrophy Presenting with Superior Arcuate Field Defect. ( 26417467 )
2015
31
Neuropsychiatric Symptoms in Posterior Cortical Atrophy and Alzheimer Disease. ( 26404166 )
2015
32
Evaluating pathogenic dementia variants in posterior cortical atrophy. ( 26507310 )
2015
33
Treatment of a patient with posterior cortical atrophy (PCA) with chiropractic manipulation and Dynamic Neuromuscular Stabilization (DNS): A case report. ( 25729084 )
2015
34
Reduced modulation of scanpaths in response to task demands in posterior cortical atrophy. ( 25596316 )
2015
35
Usefulness of Multi-Parametric MRI for the Investigation of Posterior Cortical Atrophy. ( 26480294 )
2015
36
3D Shape Perception in Posterior Cortical Atrophy: A Visual Neuroscience Perspective. ( 26377458 )
2015
37
Posterior cortical atrophy as an extreme phenotype of GRN mutations. ( 25546130 )
2015
38
Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy. ( 25895507 )
2015
39
Functional neural substrates of posterior cortical atrophy patients. ( 25976028 )
2015
40
Derailed dementia: Alzheimer's disease versus posterior cortical atrophy. ( 25688631 )
2015
41
Facilitating text reading in posterior cortical atrophy. ( 26138948 )
2015
42
Left temporal lobe epilepsy revealing left posterior cortical atrophy due to Alzheimer's disease. ( 25589715 )
2015
43
Posterior cortical atrophy: an atypical variant of Alzheimer disease. ( 25998111 )
2015
44
Posterior Cortical Atrophy: A Case Report of a 6-Year Natural Progression. ( 26704219 )
2015
45
Clinical, FDG and amyloid PET imaging in posterior cortical atrophy. ( 25862483 )
2015
46
Oculomotor abnormalities in posterior cortical atrophy: are they different from those in Alzheimer's disease after all? ( 26106096 )
2015
47
Quantitative regional validation of the visual rating scale for posterior cortical atrophy. ( 24092044 )
2014
48
(Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy. ( 24841985 )
2014
49
Visual field defect as an uncommon presentation of posterior cortical atrophy. ( 25327905 )
2014
50
Pronounced Impairment of Everyday Skills and Self-Care in Posterior Cortical Atrophy. ( 25096622 )
2014

Variations for Posterior Cortical Atrophy

Expression for Posterior Cortical Atrophy

Search GEO for disease gene expression data for Posterior Cortical Atrophy.

Pathways for Posterior Cortical Atrophy

Pathways related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.67 APOE MAPT
2 10.96 APOE MAPT
3 10.28 APOE MAPT

GO Terms for Posterior Cortical Atrophy

Cellular components related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 8.96 APOE MAPT
2 neuronal cell body GO:0043025 8.62 APOE MAPT

Molecular functions related to Posterior Cortical Atrophy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lipoprotein particle binding GO:0071813 8.62 APOE MAPT

Sources for Posterior Cortical Atrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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