MCID: PST016
MIFTS: 25

Posterior Polar Cataract malady

Categories: Genetic diseases, Eye diseases, Rare diseases, Fetal diseases

Aliases & Classifications for Posterior Polar Cataract

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Aliases & Descriptions for Posterior Polar Cataract:

Name: Posterior Polar Cataract 10 12
 
Cataract, Posterior Polar 10

Classifications:



External Ids:

Disease Ontology10 DOID:0050537

Summaries for Posterior Polar Cataract

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MalaCards based summary: Posterior Polar Cataract, also known as cataract, posterior polar, is related to early-onset posterior polar cataract and posterior polar cataract 2. An important gene associated with Posterior Polar Cataract is CRYAB (Crystallin Alpha B). Affiliated tissues include eye, heart and thyroid, and related mouse phenotype vision/eye.

Related Diseases for Posterior Polar Cataract

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Diseases in the Posterior Polar Cataract family:

Cataract 24, Anterior Polar Cataract Anterior Polar Dominant
Posterior Polar Cataract 2 Early-Onset Anterior Polar Cataract
Early-Onset Posterior Polar Cataract

Diseases related to Posterior Polar Cataract via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1early-onset posterior polar cataract32.1BFSP1, CRYAB, CRYBA1, CRYGD, GJA3
2posterior polar cataract 212.6
3cataract 11, multiple types11.9
4cataract 16, multiple types11.9
5cataract 6, multiple types11.9
6cataract 31, multiple types11.7
7breast cancer10.2
8cerebritis10.2
9endotheliitis10.2
10schizophrenia10.1
11ovarian hyperstimulation syndrome10.1
12retinoblastoma10.1
13rett syndrome10.1
14alcohol abuse10.1
15hydrocephalus10.1
16lambert-eaton myasthenic syndrome10.1
17familial adenomatous polyposis10.1
18imperforate anus10.1
19esophagitis10.1
20carotid stenosis10.1
21premature ejaculation10.1
22rheumatic fever10.1
23leiomyosarcoma10.1
24thrombocytosis10.1
25relapsing polychondritis10.1
26acanthosis nigricans10.1
27polyradiculoneuropathy10.1
28pleomorphic xanthoastrocytoma10.1
29chronic inflammatory demyelinating polyradiculoneuropathy10.1
30gastric leiomyosarcoma10.1
31adenosine deaminase deficiency10.1
32conjunctivitis10.1
33vasculitis10.1
34molluscum contagiosum10.1
35chorioretinitis10.1
36parotid gland cancer10.1
37amyloidosis10.1
38toxoplasmosis10.1
39carcinoid syndrome10.1
40chronic graft versus host disease10.1
41hypoadrenalism10.1
42cavernous malformation10.1
43early-onset zonular cataract9.6CRYGD, GJA3
44ovarian disease9.6CRYAB, GJA3, PITX3
45congenital aphakia9.6BFSP1, CRYAB, PITX3
46autosomal recessive optic atrophy, opa8 type9.5CRYAB, CRYBA1, CRYGD
47early-onset sutural cataract9.4CRYGD, GJA3
48reticular dystrophy of the retinal pigment epithelium9.4CRYAB, CRYBA1, GJA3, PITX3
49charcot-marie-tooth disease type x8.6BFSP1, CRYAB, CRYBA1, CRYGD, GJA3, PITX3
50cerebral hemorrhage8.5BFSP1, CRYAB, CRYBA1, CRYGD, GJA3, PITX3

Graphical network of the top 20 diseases related to Posterior Polar Cataract:



Diseases related to posterior polar cataract

Symptoms for Posterior Polar Cataract

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Drugs & Therapeutics for Posterior Polar Cataract

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Posterior Polar Cataract

Genetic Tests for Posterior Polar Cataract

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Anatomical Context for Posterior Polar Cataract

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MalaCards organs/tissues related to Posterior Polar Cataract:

33
Eye, Heart, Thyroid, Breast, T cells, Uterus, Ovary

Animal Models for Posterior Polar Cataract or affiliated genes

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MGI Mouse Phenotypes related to Posterior Polar Cataract:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.1BFSP1, CRYAB, CRYBA1, CRYGD, GJA3, PITX3

Publications for Posterior Polar Cataract

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Articles related to Posterior Polar Cataract:

(show top 50)    (show all 52)
idTitleAuthorsYear
1
Substernal Goiter: When is a Sternotomy Required? (25058777)
2014
2
Assessment of adenoma detection rate benchmarks in women versus men. (23375528)
2013
3
Non-pharmacological interventions for preventing venous insufficiency in a standing worker population. (24127117)
2013
4
Atomic structure of dual-specificity phosphatase 26, a novel p53 phosphatase. (23298255)
2013
5
Ecology and geography of transmission of two bat-borne rabies lineages in chile. (24349592)
2013
6
Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences. (23361464)
2013
7
Regression of liver fibrosis is progressive after sustained virological response to HCV therapy in patients with hepatitis C and HIV coinfection. (24304452)
2013
8
Newcastle disease: progress and gaps in the development of vaccines and diagnostic tools. (23689887)
2013
9
Management of acute diarrhea in emergency room. (23192407)
2013
10
A meta-analysis about the association between -1082G/A and -819C/T polymorphisms of IL-10 gene and risk of type 2 diabetes. (23376084)
2013
11
Low serum apolipoprotein A1/B ratio is associated with proliferative diabetic retinopathy in type 2 diabetes. (22327732)
2012
12
Rehabilitative treatment of cleft lip and palate: experience of the Hospital for Rehabilitation of Craniofacial Anomalies-USP (HRAC-USP)--part 2: pediatric dentistry and orthodontics. (22666849)
2012
13
Combined oral contraceptive pills for treatment of acne. (22786490)
2012
14
Clinical outcomes of 114 patients who underwent I^-knife radiosurgery for medically refractory idiopathic trigeminal neuralgia. (22154202)
2012
15
Hypermethylated DAPK in serum DNA of women with uterine leiomyoma is a biomarker not restricted to cancer. (21159370)
2011
16
Assessment of intrahepatic blood flow by Doppler ultrasonography: relationship between the hepatic vein, portal vein, hepatic artery and portal pressure measured intraoperatively in patients with portal hypertension. (21767412)
2011
17
Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report. (21621273)
2011
18
Demonstration of the effect of estrogen and progesterone receptors on survival in breast cancer without cytostatic and hormonal treatment in a small set of patients]. (20192071)
2010
19
The expression and clinical significance of AKT2, phosphorylated AKT2 in non-small cell lung cancer]. (20848774)
2010
20
The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. (19369198)
2009
21
Giant cell tumor of soft tissue of neck: a case report. (22666716)
2009
22
Two new HLA-DQB alleles routinely identified by sequence-based typing: DQB1*030103 and DQB1*0505. (19392794)
2009
23
14 bp deletion polymorphism in the HLA-G gene is a risk factor for idiopathic dilated cardiomyopathy in a Chinese Han population. (17854427)
2007
24
Characterization of HSP27 phosphorylation induced by microtubule interfering agents: implication of p38 signalling pathway. (17367746)
2007
25
Addressing nicotine dependence in psychodynamic psychotherapy: perspectives from residency training. (17242046)
2007
26
The results of surgical excision and adjuvant irradiation for therapy-resistant keloids: a prospective clinical outcome study. (17519728)
2007
27
Ring chromosome 17 epilepsy may resemble that of ring chromosome 20 syndrome. (17884758)
2007
28
Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo. (17132222)
2006
29
Cystatin C as a marker of residual renal function during continuous hemodiafiltration. (15377821)
2005
30
Mast cells in cellular leiomyoma and endometrial stromal sarcoma of the uterus]. (15196440)
2004
31
Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus. (14993646)
2004
32
Women with preeclampsia have increased serum levels of pregnancy-associated plasma protein A (PAPP-A), inhibin A, activin A and soluble E-selectin. (12648442)
2003
33
Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis. (12837526)
2003
34
Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors. (12851293)
2003
35
Co-ordinate transcriptional regulation of dopamine synthesis genes by alpha-synuclein in human neuroblastoma cell lines. (12716427)
2003
36
Effects of smoking and cytochrome P450 2D6*10 allele on the plasma haloperidol concentration/dose ratio. (14499311)
2003
37
Increased circulating levels of osteoclastogenesis inhibitory factor (osteoprotegerin) in patients with chronic renal failure. (11877571)
2002
38
Induction of transient arthritis by the adoptive transfer of a collagen II specific Th1 clone to HLA-DR4 (B1*0401) transgenic mice. (12367557)
2002
39
Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia. (10639517)
2000
40
Gap junction signalling mediated through connexin-43 is required for chick limb development. (10068470)
1999
41
An ataxia telangiectasia model: inefficient cell differentiation and possible reversal by serine protease inhibitors, tumor necrosis factor inhibitors, dexamethasone, and glutathione enhancers. (9881837)
1998
42
Biology and treatment of acute lymphocytic leukemia in children. (9045307)
1997
43
Chromosomal alterations in a case of ganglioglioma. (8548741)
1995
44
NF-AT components define a family of transcription factors targeted in T-cell activation. (8202141)
1994
45
Benign cystic teratoma of ovary containing a homunculus. (4020199)
1985
46
Peter's anomaly with congenital aphakia. (7378901)
1980
47
Follow-up studies in patients with right bundle branch block and left anterior hemiblock: significance of H-V interval. (881601)
1977
48
Pleuropneumonia of swine caused by Haemophilus parahaemolyticus. Studies on the protection obtained by vaccination. (958865)
1976
49
OPEN HEART SURGERY IN VALVULAR AND SUBVALVULAR AORTIC STENOSIS. (14127257)
1964
50
LACTOSE INTOLERANCE WITH NORMAL ACTIVITY OF LACTASE. (14212672)
1964

Variations for Posterior Polar Cataract

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Expression for genes affiliated with Posterior Polar Cataract

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Search GEO for disease gene expression data for Posterior Polar Cataract.

Pathways for genes affiliated with Posterior Polar Cataract

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GO Terms for genes affiliated with Posterior Polar Cataract

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Biological processes related to Posterior Polar Cataract according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to hydrogen peroxideGO:00425429.4CRYAB, GJA3
2lens development in camera-type eyeGO:00020889.3CRYBA1, CRYGD

Sources for Posterior Polar Cataract

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet