MCID: PST016
MIFTS: 27

Posterior Polar Cataract malady

Summaries for Posterior Polar Cataract

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46OMIM, 32MalaCards
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MalaCards: Posterior Polar Cataract, also known as cataract, posterior polar, is related to cataract and cataract, posterior polar, 3. An important gene associated with Posterior Polar Cataract is CHMP4B (charged multivesicular body protein 4B). Affiliated tissues include eye, and related mouse phenotype vision/eye.

Description from OMIM:46 610623,605387,116600,613763

Aliases & Classifications for Posterior Polar Cataract

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8Disease Ontology, 10DISEASES, 46OMIM
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Aliases & Descriptions:

posterior polar cataract 8 10
cataract, posterior polar 8


External Ids:

Disease Ontology8 DOID:0050537

Related Diseases for Posterior Polar Cataract

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Posterior Polar Cataract:



Diseases related to posterior polar cataract

Clinical Features for Posterior Polar Cataract

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46OMIM
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Clinical features from OMIM:

610623,605387,116600,613763

Drugs & Therapeutics for Posterior Polar Cataract

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Posterior Polar Cataract

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Anatomical Context for Posterior Polar Cataract

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32MalaCards
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MalaCards organs/tissues related to Posterior Polar Cataract:

32
Eye

Animal Models for Posterior Polar Cataract or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Posterior Polar Cataract:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.0SIX6, PITX3, CRYBA1, CRYBB2, CRYGD, CRYAB

Publications for Posterior Polar Cataract

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50PubMed
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Articles related to Posterior Polar Cataract:

(show all 48)
idTitleAuthorsYear
1
Posterior polar cataract: A review. (23960967)
2012
2
Phacoemulsification in eyes with posterior polar cataract. (22920002)
2012
3
Approaches to a posterior polar cataract. (23960968)
2012
4
A new locus in chromosome 2q37-qter is associated with posterior polar cataract. (21881846)
2012
5
Surgical approaches to posterior polar cataract: a review. (22441026)
2012
6
Oval capsulorhexis for phacoemulsification in posterior polar cataract with preexisting posterior capsule rupture. (21700098)
2011
7
The complications during phacoemulsification in patients with posterior polar cataract. (21853943)
2011
8
Modified technique for epinucleus removal in posterior polar cataract. (21053813)
2011
9
A novel 1-bp deletion in PITX3 causing congenital posterior polar cataract. (21633712)
2011
10
A novel GJA3 mutation associated with congenital nuclear pulverulent and posterior polar cataract in a Chinese family. (21681855)
2011
11
A splice site mutation in CRYBA1/A3 causing autosomal dominant posterior polar cataract in a Chinese pedigree. (20142846)
2010
12
Inverse horse-shoe technique for the phacoemulsification of posterior polar cataract. (20379301)
2010
13
Phacoemulsification in posterior polar cataract: does size of lens opacity affect surgical outcome? (20572822)
2010
14
Posterior polar cataract surgery: a posterior segment approach. (18989342)
2009
15
Modified epinucleus pre-chop for the dense posterior polar cataract. (18435348)
2008
16
Posterior polar cataract surgery - a posterior segment approach. (17332769)
2008
17
'Layer by layer' phacoemulsification in posterior polar cataract with pre-existing posterior capsular rent. (17417622)
2008
18
Surgical and visual outcomes for posterior polar cataract. (18728051)
2008
19
Managing the hard posterior polar cataract. (18361960)
2008
20
Bilateral spontaneous rupture of posterior capsule in posterior polar cataract. (19128390)
2008
21
Phacoemulsification with viscodissection in posterior polar cataract: minimizing risk of posterior capsule tear. (17984504)
2007
22
Posterior polar cataract: minimizing risk of posterior capsule rupture. (17304262)
2007
23
Spontaneous dislocation of posterior polar cataract. (17662445)
2007
24
Management of the hard posterior polar cataract. (17720063)
2007
25
Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. (16565358)
2006
26
A new locus for autosomal dominant posterior polar cataract in Moroccan Jews maps to chromosome 14q22-23. (17047090)
2006
27
Identification of a CRYAB mutation associated with autosomal dominant posterior polar cataract in a Chinese family. (16877416)
2006
28
Posterior polar cataract: minimizing risk of posterior capsule rupture. (16254595)
2006
29
The PITX3 gene in posterior polar congenital cataract in Australia. (16636655)
2006
30
Posterior polar cataract is the predominant consequence of a recurrent mutation in the PITX3 gene. (15665340)
2005
31
Posterior polar cataract: genetic analysis of a large family. (16272057)
2005
32
The management of posterior polar cataract: the role of patching and grading. (16361185)
2005
33
Recurrent 17 bp duplication in PITX3 is primarily associated with posterior polar cataract (CPP4). (15286169)
2004
34
Outcomes of surgery for posterior polar cataract. (12551666)
2003
35
Management of posterior polar cataract. (12551661)
2003
36
Theoretical considerations regarding the study "Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans". (12227334)
2002
37
Minimizing risk to the capsule during surgery for posterior polar cataract. (11978449)
2002
38
Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. (11577372)
2001
39
An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12. (10909854)
2000
40
Genetically distinct autosomal dominant posterior polar cataract in a four-generation Japanese family. (10682967)
2000
41
Phacoemulsification in eyes with posterior polar cataract. (9951671)
1999
42
A locus for autosomal dominant posterior polar cataract on chromosome 1p. (9002669)
1997
43
Scaphocephaly, bilateral aniridia, and bilateral anterior polar cataract with posterior dislocation of the lens. (5097399)
1971
44
Hereditary posterior polar cataract. (13364188)
1956
45
A case of familial dwarfism, with choroideremia, myopia, posterior polar cataract, and zonular cataract. (13388265)
1956
46
Hereditary posterior polar cataract with report of a pedigree. (14389647)
1955
47
Cyst in the vitreous and posterior polar cataract in retinitis pigmentosa. (20281867)
1946
48
Hereditary Posterior Polar Cataract, with Report of a Pedigree. (16692353)
1915

Genetic Variations for Posterior Polar Cataract

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Expression for genes affiliated with Posterior Polar Cataract

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Posterior Polar Cataract

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Pathways for genes affiliated with Posterior Polar Cataract

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Compounds for genes affiliated with Posterior Polar Cataract

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GO Terms for genes affiliated with Posterior Polar Cataract

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16Gene Ontology
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Biological processes related to Posterior Polar Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lens fiber cell differentiationGO:0703069.8CRYGD, PITX3
2lens development in camera-type eyeGO:0020888.9CRYGS, CRYAB, CRYGD, CRYBA1, PITX3
3visual perceptionGO:0076018.5CRYBA1, CRYBB2, CRYGD, GJA3, SIX6

Molecular functions related to Posterior Polar Cataract according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.1SIX6, SIX4, MAFB, PITX3
2structural constituent of eye lensGO:0052128.1CRYGS, BFSP1, CRYBA1, CRYBB2, CRYGD, CRYAB

Products for genes affiliated with Posterior Polar Cataract

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Sources for Posterior Polar Cataract

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet