MCID: PST016
MIFTS: 23

Posterior Polar Cataract malady

Categories: Genetic diseases, Eye diseases, Rare diseases, Fetal diseases

Aliases & Classifications for Posterior Polar Cataract

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Aliases & Descriptions for Posterior Polar Cataract:

Name: Posterior Polar Cataract 11 13
 
Cataract, Posterior Polar 11 25

Classifications:



External Ids:

Disease Ontology11 DOID:0050537

Summaries for Posterior Polar Cataract

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MalaCards based summary: Posterior Polar Cataract, also known as cataract, posterior polar, is related to posterior polar cataract 2 and cataract 16, multiple types. An important gene associated with Posterior Polar Cataract is CRYAB (Crystallin Alpha B). Affiliated tissues include eye, and related mouse phenotype vision/eye.

Related Diseases for Posterior Polar Cataract

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Graphical network of diseases related to Posterior Polar Cataract:



Diseases related to posterior polar cataract

Symptoms for Posterior Polar Cataract

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Drugs & Therapeutics for Posterior Polar Cataract

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Interventional clinical trials:

idNameStatusNCT IDPhase
1A Novel Congenital Cataract Category SystemCompletedNCT02793869

Search NIH Clinical Center for Posterior Polar Cataract

Genetic Tests for Posterior Polar Cataract

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Genetic tests related to Posterior Polar Cataract:

id Genetic test Affiliating Genes
1 Posterior Polar Cataract25

Anatomical Context for Posterior Polar Cataract

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MalaCards organs/tissues related to Posterior Polar Cataract:

34
Eye

Animal Models for Posterior Polar Cataract or affiliated genes

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MGI Mouse Phenotypes related to Posterior Polar Cataract:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.1BFSP1, CRYAB, CRYBA1, CRYGD, GJA3, PITX3

Publications for Posterior Polar Cataract

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Articles related to Posterior Polar Cataract:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Posterior polar cataract: Minimizing risks. (27546963)
2016
2
Phacoemulsification in posterior polar cataract. (27626143)
2016
3
Femtosecond Laser-assisted Cataract Surgery Technique to Enhance Safety in Posterior Polar Cataract. (26334779)
2015
4
A novel nonsense mutation in the MIP gene linked to congenital posterior polar cataracts in a Chinese family. (25803033)
2015
5
Anterior segment optical coherence tomography for demonstrating posterior capsular rent in posterior polar cataract. (24453477)
2014
6
A nonsense mutation of I^D-crystallin associated with congenital nuclear and posterior polar cataract in a Chinese family. (24465161)
2014
7
Pre-surround division technique: precise cracks surrounding the posterior opacity prior to phacoemulsification in posterior polar cataract surgery. (25442881)
2014
8
Application of anterior segment optical coherence tomography to identify eyes with posterior polar cataract at high risk for posterior capsule rupture. (25465687)
2014
9
A novel P20R mutation in the alpha-B crystallin gene causes autosomal dominant congenital posterior polar cataracts in a Chinese family. (25195561)
2014
10
Posterior polar cataract: A review. (23960967)
2012
11
Phacoemulsification in eyes with posterior polar cataract. (22920002)
2012
12
Approaches to a posterior polar cataract. (23960968)
2012
13
A new locus in chromosome 2q37-qter is associated with posterior polar cataract. (21881846)
2012
14
Surgical approaches to posterior polar cataract: a review. (22441026)
2012
15
The complications during phacoemulsification in patients with posterior polar cataract. (21853943)
2011
16
A novel 1-bp deletion in PITX3 causing congenital posterior polar cataract. (21633712)
2011
17
Oval capsulorhexis for phacoemulsification in posterior polar cataract with preexisting posterior capsule rupture. (21700098)
2011
18
Modified technique for epinucleus removal in posterior polar cataract. (21053813)
2011
19
A splice site mutation in CRYBA1/A3 causing autosomal dominant posterior polar cataract in a Chinese pedigree. (20142846)
2010
20
Inverse horse-shoe technique for the phacoemulsification of posterior polar cataract. (20379301)
2010
21
Phacoemulsification in posterior polar cataract: does size of lens opacity affect surgical outcome? (20572822)
2010
22
Posterior polar cataract surgery: a posterior segment approach. (18989342)
2009
23
Modified epinucleus pre-chop for the dense posterior polar cataract. (18435348)
2008
24
'Layer by layer' phacoemulsification in posterior polar cataract with pre-existing posterior capsular rent. (17417622)
2008
25
Surgical and visual outcomes for posterior polar cataract. (18728051)
2008
26
Managing the hard posterior polar cataract. (18361960)
2008
27
Bilateral spontaneous rupture of posterior capsule in posterior polar cataract. (19128390)
2008
28
Posterior polar cataract surgery - a posterior segment approach. (17332769)
2008
29
Phacoemulsification with viscodissection in posterior polar cataract: minimizing risk of posterior capsule tear. (17984504)
2007
30
Spontaneous dislocation of posterior polar cataract. (17662445)
2007
31
Posterior polar cataract: minimizing risk of posterior capsule rupture. (17304262)
2007
32
Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. (16565358)
2006
33
Identification of a CRYAB mutation associated with autosomal dominant posterior polar cataract in a Chinese family. (16877416)
2006
34
A new locus for autosomal dominant posterior polar cataract in Moroccan Jews maps to chromosome 14q22-23. (17047090)
2006
35
Posterior polar cataract: genetic analysis of a large family. (16272057)
2005
36
The management of posterior polar cataract: the role of patching and grading. (16361185)
2005
37
Posterior polar cataract is the predominant consequence of a recurrent mutation in the PITX3 gene. (15665340)
2005
38
Outcomes of surgery for posterior polar cataract. (12551666)
2003
39
Theoretical considerations regarding the study "Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans". (12227334)
2002
40
Minimizing risk to the capsule during surgery for posterior polar cataract. (11978449)
2002
41
Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. (11577372)
2001
42
An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12. (10909854)
2000
43
Genetically distinct autosomal dominant posterior polar cataract in a four-generation Japanese family. (10682967)
2000
44
Phacoemulsification in eyes with posterior polar cataract. (9951671)
1999
45
A locus for autosomal dominant posterior polar cataract on chromosome 1p. (9002669)
1997
46
Hereditary posterior polar cataract. (13364188)
1956
47
A case of familial dwarfism, with choroideremia, myopia, posterior polar cataract, and zonular cataract. (13388265)
1956
48
Hereditary posterior polar cataract with report of a pedigree. (14389647)
1955
49
Cyst in the vitreous and posterior polar cataract in retinitis pigmentosa. (20281867)
1946
50
Hereditary Posterior Polar Cataract, with Report of a Pedigree. (16692353)
1915

Variations for Posterior Polar Cataract

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Expression for genes affiliated with Posterior Polar Cataract

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Search GEO for disease gene expression data for Posterior Polar Cataract.

Pathways for genes affiliated with Posterior Polar Cataract

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GO Terms for genes affiliated with Posterior Polar Cataract

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Biological processes related to Posterior Polar Cataract according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to hydrogen peroxideGO:00425429.7CRYAB, GJA3
2lens fiber cell differentiationGO:00703069.4CRYGD, PITX3
3visual perceptionGO:00076018.5CRYBA1, CRYGD, GJA3
4lens development in camera-type eyeGO:00020888.1CRYAB, CRYBA1, CRYGD, PITX3

Molecular functions related to Posterior Polar Cataract according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of eye lensGO:00052128.1BFSP1, CRYAB, CRYBA1, CRYGD

Sources for Posterior Polar Cataract

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet