MCID: PST016
MIFTS: 23

Posterior Polar Cataract

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Posterior Polar Cataract

MalaCards integrated aliases for Posterior Polar Cataract:

Name: Posterior Polar Cataract 12 28 14
Cataract, Posterior Polar 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:0050537

Summaries for Posterior Polar Cataract

MalaCards based summary : Posterior Polar Cataract, also known as cataract, posterior polar, is related to cataract 30, multiple types and cataract 16, multiple types. An important gene associated with Posterior Polar Cataract is CRYAB (Crystallin Alpha B). Affiliated tissues include eye, and related phenotype is vision/eye.

Related Diseases for Posterior Polar Cataract

Graphical network of the top 20 diseases related to Posterior Polar Cataract:



Diseases related to Posterior Polar Cataract

Symptoms & Phenotypes for Posterior Polar Cataract

MGI Mouse Phenotypes related to Posterior Polar Cataract:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.1 BFSP1 CRYAB CRYBA1 CRYGD GJA3 PITX3

Drugs & Therapeutics for Posterior Polar Cataract

Search Clinical Trials , NIH Clinical Center for Posterior Polar Cataract

Genetic Tests for Posterior Polar Cataract

Genetic tests related to Posterior Polar Cataract:

# Genetic test Affiliating Genes
1 Posterior Polar Cataract 28

Anatomical Context for Posterior Polar Cataract

MalaCards organs/tissues related to Posterior Polar Cataract:

38
Eye

Publications for Posterior Polar Cataract

Articles related to Posterior Polar Cataract:

(show top 50) (show all 56)
# Title Authors Year
1
Managing the posterior polar cataract: An update. ( 29208815 )
2017
2
Phacoemulsification in posterior polar cataract. ( 27626143 )
2016
3
Posterior polar cataract: Minimizing risks. ( 27546963 )
2016
4
Femtosecond Laser-assisted Cataract Surgery Technique to Enhance Safety in Posterior Polar Cataract. ( 26334779 )
2015
5
A novel nonsense mutation in the MIP gene linked to congenital posterior polar cataracts in a Chinese family. ( 25803033 )
2015
6
Pre-surround division technique: precise cracks surrounding the posterior opacity prior to phacoemulsification in posterior polar cataract surgery. ( 25442881 )
2014
7
Anterior segment optical coherence tomography for demonstrating posterior capsular rent in posterior polar cataract. ( 24453477 )
2014
8
Application of anterior segment optical coherence tomography to identify eyes with posterior polar cataract at high risk for posterior capsule rupture. ( 25465687 )
2014
9
A nonsense mutation of I^D-crystallin associated with congenital nuclear and posterior polar cataract in a Chinese family. ( 24465161 )
2014
10
A novel P20R mutation in the alpha-B crystallin gene causes autosomal dominant congenital posterior polar cataracts in a Chinese family. ( 25195561 )
2014
11
A new locus in chromosome 2q37-qter is associated with posterior polar cataract. ( 21881846 )
2012
12
Surgical approaches to posterior polar cataract: a review. ( 22441026 )
2012
13
Approaches to a posterior polar cataract. ( 23960968 )
2012
14
Phacoemulsification in eyes with posterior polar cataract. ( 22920002 )
2012
15
Posterior polar cataract: A review. ( 23960967 )
2012
16
A novel 1-bp deletion in PITX3 causing congenital posterior polar cataract. ( 21633712 )
2011
17
Oval capsulorhexis for phacoemulsification in posterior polar cataract with preexisting posterior capsule rupture. ( 21700098 )
2011
18
The complications during phacoemulsification in patients with posterior polar cataract. ( 21853943 )
2011
19
Modified technique for epinucleus removal in posterior polar cataract. ( 21053813 )
2011
20
A novel GJA3 mutation associated with congenital nuclear pulverulent and posterior polar cataract in a Chinese family. ( 21681855 )
2011
21
Phacoemulsification in posterior polar cataract: does size of lens opacity affect surgical outcome? ( 20572822 )
2010
22
A splice site mutation in CRYBA1/A3 causing autosomal dominant posterior polar cataract in a Chinese pedigree. ( 20142846 )
2010
23
Inverse horse-shoe technique for the phacoemulsification of posterior polar cataract. ( 20379301 )
2010
24
Posterior polar cataract surgery: a posterior segment approach. ( 18989342 )
2009
25
'Layer by layer' phacoemulsification in posterior polar cataract with pre-existing posterior capsular rent. ( 17417622 )
2008
26
Modified epinucleus pre-chop for the dense posterior polar cataract. ( 18435348 )
2008
27
Posterior polar cataract surgery - a posterior segment approach. ( 17332769 )
2008
28
Surgical and visual outcomes for posterior polar cataract. ( 18728051 )
2008
29
Bilateral spontaneous rupture of posterior capsule in posterior polar cataract. ( 19128390 )
2008
30
Managing the hard posterior polar cataract. ( 18361960 )
2008
31
Management of the hard posterior polar cataract. ( 17720063 )
2007
32
Posterior polar cataract: minimizing risk of posterior capsule rupture. ( 17304262 )
2007
33
Phacoemulsification with viscodissection in posterior polar cataract: minimizing risk of posterior capsule tear. ( 17984504 )
2007
34
Spontaneous dislocation of posterior polar cataract. ( 17662445 )
2007
35
A new locus for autosomal dominant posterior polar cataract in Moroccan Jews maps to chromosome 14q22-23. ( 17047090 )
2006
36
Identification of a CRYAB mutation associated with autosomal dominant posterior polar cataract in a Chinese family. ( 16877416 )
2006
37
Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. ( 16565358 )
2006
38
Posterior polar cataract: minimizing risk of posterior capsule rupture. ( 16254595 )
2006
39
The management of posterior polar cataract: the role of patching and grading. ( 16361185 )
2005
40
Posterior polar cataract is the predominant consequence of a recurrent mutation in the PITX3 gene. ( 15665340 )
2005
41
Posterior polar cataract: genetic analysis of a large family. ( 16272057 )
2005
42
Recurrent 17 bp duplication in PITX3 is primarily associated with posterior polar cataract (CPP4). ( 15286169 )
2004
43
Outcomes of surgery for posterior polar cataract. ( 12551666 )
2003
44
Management of posterior polar cataract. ( 12551661 )
2003
45
Minimizing risk to the capsule during surgery for posterior polar cataract. ( 11978449 )
2002
46
Theoretical considerations regarding the study "Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans". ( 12227334 )
2002
47
Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans. ( 11577372 )
2001
48
An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12. ( 10909854 )
2000
49
Genetically distinct autosomal dominant posterior polar cataract in a four-generation Japanese family. ( 10682967 )
2000
50
Phacoemulsification in eyes with posterior polar cataract. ( 9951671 )
1999

Variations for Posterior Polar Cataract

Expression for Posterior Polar Cataract

Search GEO for disease gene expression data for Posterior Polar Cataract.

Pathways for Posterior Polar Cataract

GO Terms for Posterior Polar Cataract

Biological processes related to Posterior Polar Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.33 CRYBA1 CRYGD GJA3
2 aging GO:0007568 9.26 CRYAB PITX3
3 lens fiber cell differentiation GO:0070306 8.96 CRYGD PITX3
4 lens development in camera-type eye GO:0002088 8.92 CRYAB CRYBA1 CRYGD PITX3

Molecular functions related to Posterior Polar Cataract according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.92 BFSP1 CRYAB CRYBA1 CRYGD

Sources for Posterior Polar Cataract

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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