MCID: PST061
MIFTS: 19

Posterior Polymorphous Corneal Dystrophy malady

Summaries for Posterior Polymorphous Corneal Dystrophy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Posterior Polymorphous Corneal Dystrophy (PPCD; sometimes also Schlichting dystrophy) is a type of... more...

MalaCards: Posterior Polymorphous Corneal Dystrophy, also known as polymorphous corneal dystrophy, is related to corneal dystrophy and fuchs' endothelial dystrophy. An important gene associated with Posterior Polymorphous Corneal Dystrophy is VSX1 (visual system homeobox 1), and among its related pathways are Integrin Pathway and PTEN Pathway. Affiliated tissues include endothelial, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Aliases & Classifications for Posterior Polymorphous Corneal Dystrophy

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20GeneTests, 44Novoseek, 60UMLS
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Aliases & Descriptions:

posterior polymorphous corneal dystrophy 20 44
polymorphous corneal dystrophy 60


Related Diseases for Posterior Polymorphous Corneal Dystrophy

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17GeneCards, 18GeneDecks
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Diseases in the Corneal Dystrophy Polymorphous Posterior, 2 family:

posterior polymorphous corneal dystrophy Corneal Dystrophy, Posterior Polymorphous, 3

Diseases related to Posterior Polymorphous Corneal Dystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1corneal dystrophy31.5COL8A2, COL8A1, VSX1, SLC4A11
2fuchs' endothelial dystrophy30.7COL8A1
3keratoconus30.5COL8A2, VSX1
4glaucoma30.3VSX1
5corneal dystrophy, hereditary polymorphous posterior10.5
6corneal disease10.4
7juvenile glaucoma10.2
8cataract10.2
9polymicrogyria with seizures10.1
10corneal edema10.0VSX1, SLC4A11
11alport syndrome10.0COL4A3, VSX1

Graphical network of diseases related to Posterior Polymorphous Corneal Dystrophy:



Diseases related to posterior polymorphous corneal dystrophy

Clinical Features for Posterior Polymorphous Corneal Dystrophy

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Drugs & Therapeutics for Posterior Polymorphous Corneal Dystrophy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Posterior Polymorphous Corneal Dystrophy

Drug clinical trials:

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Search NIH Clinical Center for Posterior Polymorphous Corneal Dystrophy

Search CenterWatch for Posterior Polymorphous Corneal Dystrophy

Genetic Tests for Posterior Polymorphous Corneal Dystrophy

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20GeneTests
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Genetic tests related to Posterior Polymorphous Corneal Dystrophy:

id Genetic test Affiliating Genes
1 Posterior Polymorphous Corneal Dystrophy20

Anatomical Context for Posterior Polymorphous Corneal Dystrophy

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32MalaCards
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MalaCards organs/tissues related to Posterior Polymorphous Corneal Dystrophy:

32
Endothelial

Animal Models for Posterior Polymorphous Corneal Dystrophy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Posterior Polymorphous Corneal Dystrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.9SLC4A11, ZEB1, COL4A3
2MP:00053917.3SLC4A11, VSX1, ZEB1, COL8A1, COL4A3, COL8A2

Publications for Posterior Polymorphous Corneal Dystrophy

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Genetic Variations for Posterior Polymorphous Corneal Dystrophy

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Expression for genes affiliated with Posterior Polymorphous Corneal Dystrophy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Posterior Polymorphous Corneal Dystrophy

Search GEO for disease gene expression data for Posterior Polymorphous Corneal Dystrophy.

Pathways for genes affiliated with Posterior Polymorphous Corneal Dystrophy

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51QIAGEN, 53Reactome
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Compounds for genes affiliated with Posterior Polymorphous Corneal Dystrophy

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GO Terms for genes affiliated with Posterior Polymorphous Corneal Dystrophy

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16Gene Ontology
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Cellular components related to Posterior Polymorphous Corneal Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.5COL8A1, COL8A2
2basement membraneGO:0056048.8COL8A1, COL4A3, COL8A2
3endoplasmic reticulum lumenGO:0057888.6COL8A1, COL4A3, COL8A2

Biological processes related to Posterior Polymorphous Corneal Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epithelial cell proliferationGO:0506739.4COL8A1, COL8A2
2camera-type eye morphogenesisGO:0485939.2COL8A1, COL8A2
3collagen catabolic processGO:0305748.9COL8A1, COL8A2, COL4A3
4extracellular matrix disassemblyGO:0226178.9COL8A1, COL8A2, COL4A3
5extracellular matrix organizationGO:0301988.9COL4A3, COL8A2, COL8A1

Molecular functions related to Posterior Polymorphous Corneal Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052019.4COL4A3, COL8A2

Products for genes affiliated with Posterior Polymorphous Corneal Dystrophy

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  • Antibodies
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Sources for Posterior Polymorphous Corneal Dystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet