MCID: PST008
MIFTS: 35

Posterior Scleritis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Posterior Scleritis

MalaCards integrated aliases for Posterior Scleritis:

Name: Posterior Scleritis 12 14 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13676
ICD10 32 H15.03
ICD9CM 34 379.07
UMLS 69 C0155357

Summaries for Posterior Scleritis

MalaCards based summary : Posterior Scleritis is related to vasculitis and scleritis. An important gene associated with Posterior Scleritis is TNFRSF10A (TNF Receptor Superfamily Member 10a), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. The drugs Methotrexate and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are cellular and hematopoietic system

Related Diseases for Posterior Scleritis

Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Posterior Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 vasculitis 28.6 PRTN3 TNF
2 scleritis 10.7
3 choroiditis 10.3
4 transient arthritis 10.3 MRAP TNFRSF10A
5 retinitis 10.2
6 granuloma inguinale 10.2 CD22 MRAP
7 skeletal tuberculosis 10.2 MRAP TNFRSF10A
8 chronic orbital inflammation 10.2 MRAP PRTN3
9 diffuse infiltrative lymphocytosis syndrome 10.0 CD19 MRAP
10 colon lymphoma 10.0 CD19 CD22
11 retinal detachment 10.0
12 necrobiotic xanthogranuloma 10.0
13 small intestine lymphoma 10.0 CD19 CD22
14 central nervous system vasculitis 10.0 TNF TNFRSF10A
15 scleral disease 10.0 MRAP TNF
16 pustulosis of palm and sole 9.9 MRAP TNF
17 post-transplant lymphoproliferative disease 9.9 TNF TNFRSF10A
18 lung lymphoma 9.9 CD19 CD22
19 acute salpingitis 9.9 MRAP TNF
20 mycobacterium tuberculosis 1 9.9
21 vogt-koyanagi-harada disease 9.9
22 melanoma 9.9
23 coccidiosis 9.9 MRAP TNF
24 panuveitis 9.9 MRAP TNF
25 myositis 9.8
26 episodic pain syndrome, familial, 1 9.8
27 arthritis 9.8
28 orbital cellulitis 9.8
29 uveitis 9.8
30 cellulitis 9.8
31 herpes zoster 9.8
32 herpes zoster ophthalmicus 9.8
33 hypersensitivity reaction type iv disease 9.8 MRAP TNF
34 encephalitozoonosis 9.8 CD19 TNF
35 transient hypogammaglobulinemia 9.8 CD19 TNF
36 spondyloarthropathy 9.8 MRAP TNF
37 middle ear disease 9.8 PRTN3 TNF
38 churg-strauss syndrome 9.8 PRTN3 TNF
39 monoclonal gammopathy of uncertain significance 9.8 CD19 TNF
40 spondyloarthropathy 1 9.8 MRAP TNF
41 intestinal disease 9.7 MRAP TNF
42 leukemia, chronic lymphocytic 2 9.7
43 keratitis, hereditary 9.7
44 leukemia, chronic lymphocytic 9.7
45 systemic lupus erythematosus 9.7
46 rheumatoid arthritis 9.7
47 sturge-weber syndrome 9.7
48 temporal arteritis 9.7
49 aging 9.7
50 psoriatic arthritis 9.7

Graphical network of the top 20 diseases related to Posterior Scleritis:



Diseases related to Posterior Scleritis

Symptoms & Phenotypes for Posterior Scleritis

MGI Mouse Phenotypes related to Posterior Scleritis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 CD19 CD22 OGG1 PRTN3 TNF TNFRSF10A
2 hematopoietic system MP:0005397 9.63 CD19 CD22 OGG1 PRTN3 TNF TNFRSF10A
3 immune system MP:0005387 9.43 CD19 CD22 OGG1 PRTN3 TNF TNFRSF10A
4 neoplasm MP:0002006 8.92 CD19 OGG1 TNF TNFRSF10A

Drugs & Therapeutics for Posterior Scleritis

Drugs for Posterior Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Infliximab Approved Phase 2 170277-31-3
4
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
5 Alkylating Agents Phase 2
6 glucocorticoids Phase 2
7 Gastrointestinal Agents Phase 2
8 Hormone Antagonists Phase 2
9 Dermatologic Agents Phase 2
10 Hormones Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
12 Immunosuppressive Agents Phase 2
13 Anti-Inflammatory Agents Phase 2
14 Antineoplastic Agents, Hormonal Phase 2
15 Antirheumatic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2 Infliximab;Cyclophosphamide

Search NIH Clinical Center for Posterior Scleritis

Genetic Tests for Posterior Scleritis

Anatomical Context for Posterior Scleritis

MalaCards organs/tissues related to Posterior Scleritis:

38
Eye

Publications for Posterior Scleritis

Articles related to Posterior Scleritis:

(show top 50) (show all 122)
# Title Authors Year
1
Posterior scleritis follow-up by Swept-Source optical coherence tomography. ( 29169639 )
2018
2
Severe Idiopathic Posterior Scleritis in a Patient with HIV. ( 28147399 )
2017
3
IgG4-related disease presenting as posterior scleritis and vitritis, progressing to multifocal orbital involvement. ( 28438752 )
2017
4
Posterior Scleritis with Choroidal Effusion Secondary to Herpes Zoster Ophthalmicus. ( 28981391 )
2017
5
Bilateral Posterior Scleritis Associated with Giant Cell Arteritis: A Case Report. ( 28914559 )
2017
6
Isolated posterior scleritis associated with tuberculosis. ( 27224075 )
2016
7
Trigeminal autonomic cephalgia caused by recurrent posterior scleritis. ( 27495133 )
2016
8
Poststreptococcal syndrome presenting as posterior scleritis in a child. ( 28007653 )
2016
9
Posterior scleritis in pediatric age group: A case report and review of literature. ( 27013832 )
2016
10
A Case of Necrobiotic Xanthogranuloma Presenting as Bilateral Posterior Scleritis. ( 27775456 )
2016
11
An unusual case of ocular tuberculosis presenting as subretinal abscess with posterior scleritis. ( 27193122 )
2016
12
Posterior Scleritis and Necrobiotic Xanthogranuloma. ( 26717063 )
2016
13
Posterior scleritis presenting as conjunctivitis in a child. ( 27941114 )
2016
14
Recurrent Unilateral Vogt-Koyanagi-Harada Disease with Posterior Scleritis. ( 26457043 )
2015
15
Posterior Scleritis with Inflammatory Retinal Detachment. ( 26759674 )
2015
16
Bilateral Posterior Scleritis: Analysis of 18 Cases from a Large Cohort of Posterior Scleritis. ( 26471249 )
2015
17
Nodular Posterior Scleritis Mimicking Choroidal Tumor in a Patient With Systemic Lupus Erythematous: A Case Report and Literature Review. ( 26692258 )
2015
18
A case of giant nodular posterior scleritis mimicking choroidal malignancy. ( 26862098 )
2015
19
A case of nodular posterior scleritis mimicking choroidal mass. ( 25892938 )
2015
20
Optical coherence tomography in the management of posterior scleritis. ( 26265857 )
2015
21
NODULAR POSTERIOR SCLERITIS: Clinico-Sonographic Characteristics and Proposed Diagnostic Criteria. ( 26296144 )
2015
22
Posterior Scleritis: Analysis of Epidemiology, Clinical Factors, and Risk of Recurrence in a Cohort of 114 Patients. ( 26134101 )
2015
23
An atypical case of bilateral posterior scleritis in a patient with chronic lymphocytic leukemia. ( 26257236 )
2015
24
Bilateral Posterior Scleritis Presenting as the First Manifestation of Immunoglobulin A Nephropathy: Case Report and Review of the Literature. ( 25290901 )
2014
25
Bilateral posterior scleritis as a presenting manifestation of giant cell arteritis: A case report. ( 25433749 )
2014
26
Choroidal observations in posterior scleritis using high-penetration optical coherence tomography. ( 24398712 )
2014
27
Posterior scleritis with retinal pigment epithelium rip: an unusual presentation. ( 25523863 )
2014
28
Clinical Features and Presentation of Posterior Scleritis: A Report of 31 Cases. ( 24131324 )
2013
29
Enhanced depth imaging optical coherence tomography of the choroid in recurrent unilateral posterior scleritis. ( 22395202 )
2013
30
Enhanced depth imaging optical coherence tomography of the choroid in new-onset acute posterior scleritis. ( 23381654 )
2013
31
Combined anterior and posterior scleritis associated with central retinal vein occlusion: a case report. ( 22411459 )
2012
32
Posterior scleritis in children: clinical features and treatment. ( 22137553 )
2012
33
Posterior scleritis resembling acute retinal necrosis syndrome. ( 25390725 )
2012
34
Fatal Pneumocystis jirovecii pneumonia following immunosuppressive therapy with rituximab and prednisolone for posterior scleritis. ( 21649871 )
2012
35
Pediatric posterior scleritis. ( 22749104 )
2012
36
Stellate neuroretinitis associated with posterior scleritis. ( 25390952 )
2012
37
Posterior scleritis in a 9-year-old boy: a case report. ( 25390705 )
2012
38
Posterior scleritis presenting with angle closure glaucoma. ( 22439667 )
2012
39
Intravitreal bevacizumab (avastin) as an adjuvant for the treatment of posterior scleritis. ( 21860578 )
2011
40
Nodular posterior scleritis mimicking choroidal metastasis: a report of two cases. ( 21760715 )
2011
41
Adjunctive globe magnetic resonance imaging in the diagnosis of posterior scleritis. ( 21816252 )
2011
42
Bilateral disc swelling associated with posterior scleritis. ( 20508658 )
2010
43
Posterior scleritis mimicking orbital cellulitis. ( 20819053 )
2010
44
Bilateral posterior scleritis: an idiopathic painless presentation. ( 20932196 )
2010
45
Posterior scleritis in patients with systemic lupus erythematosus. ( 25390910 )
2010
46
Cluster-like headache caused by posterior scleritis. ( 19250284 )
2009
47
Necrobiotic xanthogranuloma masquerading as posterior scleritis. ( 18292782 )
2009
48
Posterior scleritis presenting with simultaneous branch retinal artery occlusion and exudative retinal detachment. ( 18617904 )
2009
49
A case of atypical Cogan's syndrome with posterior scleritis and uveitis. ( 20020252 )
2009
50
Posterior scleritis: a rare pediatric disorder. ( 19483139 )
2009

Variations for Posterior Scleritis

Expression for Posterior Scleritis

Search GEO for disease gene expression data for Posterior Scleritis.

Pathways for Posterior Scleritis

GO Terms for Posterior Scleritis

Biological processes related to Posterior Scleritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.16 TNF TNFRSF10A
2 extrinsic apoptotic signaling pathway GO:0097191 8.96 TNF TNFRSF10A
3 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 8.62 TNF TNFRSF10A

Sources for Posterior Scleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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