MCID: PST008
MIFTS: 35

Posterior Scleritis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Posterior Scleritis

Aliases & Descriptions for Posterior Scleritis:

Name: Posterior Scleritis 12 14 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13676
ICD10 33 H15.03
ICD9CM 35 379.07
UMLS 69 C0155357

Summaries for Posterior Scleritis

MalaCards based summary : Posterior Scleritis is related to tuberculosis and uveitis. An important gene associated with Posterior Scleritis is TNFRSF10A (TNF Receptor Superfamily Member 10a), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and B Cell Receptor Signaling Pathway (sino). The drugs beta-endorphin and Adrenocorticotropic Hormone have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are cellular and hematopoietic system

Related Diseases for Posterior Scleritis

Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Posterior Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 29.6 CD4 TNF
2 uveitis 29.5 CD4 TNF
3 scleritis 10.6
4 vulvar sarcoma 10.2 MRAP TNFRSF10A
5 choroiditis 10.2
6 primary lacrimal atrophy 10.2 MRAP PRTN3
7 occupational dermatitis 10.1 MRAP TNF
8 bladder calculus 10.1 MRAP TNF
9 female breast upper-inner quadrant cancer 10.1 MRAP TNFRSF10A
10 penile disease 10.1 CD19 CD22
11 urethral intrinsic sphincter deficiency 10.1 MRAP TNF
12 nephronophthisis 1, juvenile 10.1 MRAP TNF
13 primary ciliary dyskinesia 10.1 TNF TNFRSF10A
14 somatostatinoma 10.1 CD19 CD22
15 retinitis 10.1
16 conjunctival vascular disease 10.1 MRAP TNF
17 basal ganglia disease 10.1 CD19 CD22
18 pneumoconiosis due to talc 10.1 CD4 TNFRSF10A
19 angiolipoma 10.1 CD4 MRAP
20 childhood pleomorphic rhabdomyosarcoma 10.1 CD19 TNF
21 astrocytoma 10.0 PRTN3 TNF
22 intravascular angioleiomyoma 10.0 CD4 MRAP
23 46 xy gonadal dysgenesis 10.0 CD4 PRTN3
24 infundibulocystic basal cell carcinoma 10.0 CD19 CD4
25 mixed germ cell cancer 10.0 CD19 CD4
26 polyneuropathy due to drug 10.0 CD19 CD4
27 red-green color blindness 10.0 CD4 TNFRSF10A
28 cerebrum cancer 10.0 CD19 CD4
29 elephantiasis 10.0 CD4 PRTN3
30 janus kinase-3 deficiency 10.0 CD4 TNFRSF10A
31 tall cell variant papillary carcinoma 10.0 CD19 CD22
32 dermatitis herpetiformis 10.0 CD4 TNF
33 transient tic disorder 10.0 CD4 TNF
34 vestibule of mouth cancer 10.0 CD4 TNF
35 chronic wasting disease 10.0 CD19 CD22 PRTN3
36 hypoparathyroidism-retardation-dysmorphism syndrome 9.9 CD4 TNF
37 congenital hypothyroidism 9.9 CD4 TNF
38 sarcomatoid transitional cell carcinoma 9.9 CD4 TNF
39 parasitic ichthyosporea infectious disease 9.9 CD4 TNF
40 pneumoconiosis 9.9 CD4 TNF
41 phlyctenulosis 9.9 CD4 TNF
42 autoimmune disease of skin and connective tissue 9.9 CD4 TNFRSF10A
43 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 9.9 CD4 TNF
44 oral cavity cancer 9.9 CD4 TNF
45 splenic artery aneurysm 9.9 CD4 TNF
46 visceral leishmaniasis 9.9 CD22 CD4 MRAP
47 wound botulism 9.9 CD4 TNF
48 necrobiotic xanthogranuloma 9.9
49 retinal detachment 9.9
50 chordoid meningioma 9.9 CD19 TNF

Graphical network of the top 20 diseases related to Posterior Scleritis:



Diseases related to Posterior Scleritis

Symptoms & Phenotypes for Posterior Scleritis

MGI Mouse Phenotypes related to Posterior Scleritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 CD19 CD22 CD4 OGG1 PRTN3 TNF
2 hematopoietic system MP:0005397 9.7 CD19 CD22 CD4 OGG1 PRTN3 TNF
3 immune system MP:0005387 9.5 CD22 CD4 OGG1 PRTN3 TNF TNFRSF10A
4 neoplasm MP:0002006 8.92 CD19 OGG1 TNF TNFRSF10A

Drugs & Therapeutics for Posterior Scleritis

Drugs for Posterior Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 beta-endorphin Phase 4
2 Adrenocorticotropic Hormone Phase 4
3 Hormone Antagonists Phase 4,Phase 2
4 Hormones Phase 4,Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
6 Melanocyte-Stimulating Hormones Phase 4
7
Infliximab Approved Phase 2,Phase 1 170277-31-3
8
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
9
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
10
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
11 Gastrointestinal Agents Phase 2,Phase 1
12 Dermatologic Agents Phase 2,Phase 1
13 Immunosuppressive Agents Phase 2,Phase 1
14 Anti-Inflammatory Agents Phase 2
15 Antirheumatic Agents Phase 2,Phase 1
16 Alkylating Agents Phase 2
17 glucocorticoids Phase 2
18 Antineoplastic Agents, Alkylating Phase 2
19 Antineoplastic Agents, Hormonal Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4
2 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2
3 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1
4 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438
5 Human Samples and Data Repository Completed NCT00539370

Search NIH Clinical Center for Posterior Scleritis

Genetic Tests for Posterior Scleritis

Anatomical Context for Posterior Scleritis

MalaCards organs/tissues related to Posterior Scleritis:

39
Eye

Publications for Posterior Scleritis

Articles related to Posterior Scleritis:

(show top 50) (show all 117)
id Title Authors Year
1
Isolated posterior scleritis associated with tuberculosis. ( 27224075 )
2016
2
Posterior Scleritis and Necrobiotic Xanthogranuloma. ( 26717063 )
2016
3
Poststreptococcal syndrome presenting as posterior scleritis in a child. ( 28007653 )
2016
4
An unusual case of ocular tuberculosis presenting as subretinal abscess with posterior scleritis. ( 27193122 )
2016
5
Posterior scleritis in pediatric age group: A case report and review of literature. ( 27013832 )
2016
6
Posterior scleritis presenting as conjunctivitis in a child. ( 27941114 )
2016
7
A Case of Necrobiotic Xanthogranuloma Presenting as Bilateral Posterior Scleritis. ( 27775456 )
2016
8
Trigeminal autonomic cephalgia caused by recurrent posterior scleritis. ( 27495133 )
2016
9
Posterior Scleritis with Inflammatory Retinal Detachment. ( 26759674 )
2015
10
Nodular Posterior Scleritis Mimicking Choroidal Tumor in a Patient With Systemic Lupus Erythematous: A Case Report and Literature Review. ( 26692258 )
2015
11
Optical coherence tomography in the management of posterior scleritis. ( 26265857 )
2015
12
A case of nodular posterior scleritis mimicking choroidal mass. ( 25892938 )
2015
13
Bilateral Posterior Scleritis: Analysis of 18 Cases from a Large Cohort of Posterior Scleritis. ( 26471249 )
2015
14
A case of giant nodular posterior scleritis mimicking choroidal malignancy. ( 26862098 )
2015
15
Recurrent Unilateral Vogt-Koyanagi-Harada Disease with Posterior Scleritis. ( 26457043 )
2015
16
Posterior Scleritis: Analysis of Epidemiology, Clinical Factors, and Risk of Recurrence in a Cohort of 114 Patients. ( 26134101 )
2015
17
An atypical case of bilateral posterior scleritis in a patient with chronic lymphocytic leukemia. ( 26257236 )
2015
18
NODULAR POSTERIOR SCLERITIS: Clinico-Sonographic Characteristics and Proposed Diagnostic Criteria. ( 26296144 )
2015
19
Posterior scleritis with retinal pigment epithelium rip: an unusual presentation. ( 25523863 )
2014
20
Bilateral posterior scleritis as a presenting manifestation of giant cell arteritis: A case report. ( 25433749 )
2014
21
Choroidal observations in posterior scleritis using high-penetration optical coherence tomography. ( 24398712 )
2014
22
Bilateral Posterior Scleritis Presenting as the First Manifestation of Immunoglobulin A Nephropathy: Case Report and Review of the Literature. ( 25290901 )
2014
23
Clinical Features and Presentation of Posterior Scleritis: A Report of 31 Cases. ( 24131324 )
2013
24
Enhanced depth imaging optical coherence tomography of the choroid in new-onset acute posterior scleritis. ( 23381654 )
2013
25
Enhanced depth imaging optical coherence tomography of the choroid in recurrent unilateral posterior scleritis. ( 22395202 )
2013
26
Posterior scleritis in a 9-year-old boy: a case report. ( 25390705 )
2012
27
Posterior scleritis resembling acute retinal necrosis syndrome. ( 25390725 )
2012
28
Combined anterior and posterior scleritis associated with central retinal vein occlusion: a case report. ( 22411459 )
2012
29
Stellate neuroretinitis associated with posterior scleritis. ( 25390952 )
2012
30
Fatal Pneumocystis jirovecii pneumonia following immunosuppressive therapy with rituximab and prednisolone for posterior scleritis. ( 21649871 )
2012
31
Posterior scleritis in children: clinical features and treatment. ( 22137553 )
2012
32
Posterior scleritis presenting with angle closure glaucoma. ( 22439667 )
2012
33
Pediatric posterior scleritis. ( 22749104 )
2012
34
Intravitreal bevacizumab (avastin) as an adjuvant for the treatment of posterior scleritis. ( 21860578 )
2011
35
Adjunctive globe magnetic resonance imaging in the diagnosis of posterior scleritis. ( 21816252 )
2011
36
Nodular posterior scleritis mimicking choroidal metastasis: a report of two cases. ( 21760715 )
2011
37
Posterior scleritis mimicking orbital cellulitis. ( 20819053 )
2010
38
Posterior scleritis in patients with systemic lupus erythematosus. ( 25390910 )
2010
39
Bilateral posterior scleritis: an idiopathic painless presentation. ( 20932196 )
2010
40
Bilateral disc swelling associated with posterior scleritis. ( 20508658 )
2010
41
A case of atypical Cogan's syndrome with posterior scleritis and uveitis. ( 20020252 )
2009
42
Posterior scleritis: a rare pediatric disorder. ( 19483139 )
2009
43
Cluster-like headache caused by posterior scleritis. ( 19250284 )
2009
44
Necrobiotic xanthogranuloma masquerading as posterior scleritis. ( 18292782 )
2009
45
Posterior scleritis presenting with simultaneous branch retinal artery occlusion and exudative retinal detachment. ( 18617904 )
2009
46
Optical coherence tomography findings in a child with posterior scleritis. ( 18988177 )
2008
47
Recurrent posterior scleritis and orbital myositis as extra-intestinal manifestations of Crohn's disease: Case report and systematic literature review. ( 21172235 )
2008
48
Ciliochoroidal effusion syndrome associated with posterior scleritis. ( 17295141 )
2007
49
Posterior scleritis and its association with HLA B27 haplotype. ( 17579295 )
2007
50
Recreational use of 3,4-methylenedioxymethamphetamine ('ecstasy') relieving symptoms of posterior scleritis. ( 17891054 )
2007

Variations for Posterior Scleritis

Expression for Posterior Scleritis

Search GEO for disease gene expression data for Posterior Scleritis.

Pathways for Posterior Scleritis

GO Terms for Posterior Scleritis

Cellular components related to Posterior Scleritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.5 CD19 CD22 CD4 MRAP PRTN3 TNF
2 external side of plasma membrane GO:0009897 8.8 CD19 CD4 TNF

Biological processes related to Posterior Scleritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase activity GO:0045860 9.26 CD4 TNF
2 extrinsic apoptotic signaling pathway GO:0097191 9.16 TNF TNFRSF10A
3 cell surface receptor signaling pathway GO:0007166 9.13 CD19 CD4 TNFRSF10A
4 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 8.62 TNF TNFRSF10A

Sources for Posterior Scleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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