MCID: PST008
MIFTS: 33

Posterior Scleritis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Posterior Scleritis

MalaCards integrated aliases for Posterior Scleritis:

Name: Posterior Scleritis 12 14 69

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:13676
ICD10 33 H15.03
ICD9CM 35 379.07
UMLS 69 C0155357

Summaries for Posterior Scleritis

MalaCards based summary : Posterior Scleritis is related to lymphoma and scleritis. An important gene associated with Posterior Scleritis is TNFRSF10A (TNF Receptor Superfamily Member 10a), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions. The drugs Infliximab and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are cellular and hematopoietic system

Related Diseases for Posterior Scleritis

Diseases in the Scleritis family:

Posterior Scleritis Anterior Scleritis

Diseases related to Posterior Scleritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Related Disease Score Top Affiliating Genes
1 lymphoma 28.7 PRTN3 TNF TNFRSF10A
2 scleritis 10.6
3 vulvar sarcoma 10.4 MRAP TNFRSF10A
4 female breast upper-inner quadrant cancer 10.3 MRAP TNFRSF10A
5 lower gum cancer 10.3 CD22 MRAP
6 primary lacrimal atrophy 10.3 MRAP PRTN3
7 choroiditis 10.2
8 achard syndrome 10.1 CD19 MRAP
9 retinitis 10.1
10 penile disease 10.1 CD19 CD22
11 solitary bone cyst 10.0 CD19 CD22
12 villoglandular endometrial endometrioid adenocarcinoma 10.0 CD19 CD22
13 central nervous system leiomyosarcoma 10.0 TNF TNFRSF10A
14 bladder calculus 10.0 MRAP TNF
15 dermatosis papulosa nigra 10.0 MRAP TNF
16 primary biliary cirrhosis 10.0 TNF TNFRSF10A
17 discitis 10.0 MRAP TNF
18 tularemia 10.0 MRAP TNF
19 cryptococcosis 9.9 MRAP TNF
20 necrobiotic xanthogranuloma 9.9
21 retinal detachment 9.9
22 malignant melanocytic peripheral nerve sheath tumor of mediastinum 9.9 CD19 CD22
23 membranoproliferative glomerulonephritis 9.8 MRAP TNF
24 melanoma 9.8
25 tuberculosis 9.8
26 vogt-koyanagi-harada disease 9.8
27 type 1 papillary adenoma of the kidney 9.8 CD19 TNF
28 testicular infarct 9.8 PRTN3 TNF
29 glioblastoma multiforme 9.7 PRTN3 TNF
30 arthritis 9.7
31 cellulitis 9.7
32 orbital cellulitis 9.7
33 myositis 9.7
34 uveitis 9.7
35 psoriasis susceptibility 1 9.7 MRAP TNF
36 asbestosis 9.6 OGG1 TNF
37 endometrial clear cell adenocarcinoma 9.6 MRAP TNF
38 acne 9.6
39 hypothyroidism 9.6
40 pyoderma gangrenosum 9.6
41 vasculitis 9.6
42 chronic lymphocytic leukemia 9.6
43 central retinal vein occlusion 9.6
44 lupus erythematosus 9.6
45 crohn's disease 9.6
46 central nervous system lymphoma 9.6
47 anterior uveitis 9.6
48 leukemia 9.6
49 herpes zoster ophthalmicus 9.6
50 retinal vein occlusion 9.6

Graphical network of the top 20 diseases related to Posterior Scleritis:



Diseases related to Posterior Scleritis

Symptoms & Phenotypes for Posterior Scleritis

MGI Mouse Phenotypes related to Posterior Scleritis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 CD19 CD22 OGG1 PRTN3 TNF TNFRSF10A
2 hematopoietic system MP:0005397 9.63 CD19 CD22 OGG1 PRTN3 TNF TNFRSF10A
3 immune system MP:0005387 9.43 TNF TNFRSF10A CD19 CD22 OGG1 PRTN3
4 neoplasm MP:0002006 8.92 CD19 OGG1 TNF TNFRSF10A

Drugs & Therapeutics for Posterior Scleritis

Drugs for Posterior Scleritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 2,Phase 1 170277-31-3
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
4
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
5 Anti-Inflammatory Agents Phase 2
6 Antirheumatic Agents Phase 2,Phase 1
7 Dermatologic Agents Phase 2,Phase 1
8 Gastrointestinal Agents Phase 2,Phase 1
9 Immunosuppressive Agents Phase 2,Phase 1
10 Alkylating Agents Phase 2
11 Antineoplastic Agents, Hormonal Phase 2
12 glucocorticoids Phase 2
13 Hormone Antagonists Phase 2
14 Hormones Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Cyclophosphamide vs. Infliximab for Refractory Idiopathic Scleritis (CIRIS) Not yet recruiting NCT03088293 Phase 2 Infliximab;Cyclophosphamide
2 Infliximab to Treat Non-Infectious Scleritis Completed NCT00075075 Phase 1 Infliximab
3 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Anti-toxoplasmosis treatment;Anti-inflammatory treatments
4 Human Samples and Data Repository Completed NCT00539370

Search NIH Clinical Center for Posterior Scleritis

Genetic Tests for Posterior Scleritis

Anatomical Context for Posterior Scleritis

MalaCards organs/tissues related to Posterior Scleritis:

39
Eye

Publications for Posterior Scleritis

Articles related to Posterior Scleritis:

(show top 50) (show all 120)
id Title Authors Year
1
Bilateral Posterior Scleritis Associated with Giant Cell Arteritis: A Case Report. ( 28914559 )
2017
2
IgG4-related disease presenting as posterior scleritis and vitritis, progressing to multifocal orbital involvement. ( 28438752 )
2017
3
Severe Idiopathic Posterior Scleritis in a Patient with HIV. ( 28147399 )
2017
4
Posterior scleritis presenting as conjunctivitis in a child. ( 27941114 )
2016
5
Isolated posterior scleritis associated with tuberculosis. ( 27224075 )
2016
6
Poststreptococcal syndrome presenting as posterior scleritis in a child. ( 28007653 )
2016
7
A Case of Necrobiotic Xanthogranuloma Presenting as Bilateral Posterior Scleritis. ( 27775456 )
2016
8
Posterior Scleritis and Necrobiotic Xanthogranuloma. ( 26717063 )
2016
9
Trigeminal autonomic cephalgia caused by recurrent posterior scleritis. ( 27495133 )
2016
10
An unusual case of ocular tuberculosis presenting as subretinal abscess with posterior scleritis. ( 27193122 )
2016
11
Posterior scleritis in pediatric age group: A case report and review of literature. ( 27013832 )
2016
12
Posterior Scleritis: Analysis of Epidemiology, Clinical Factors, and Risk of Recurrence in a Cohort of 114 Patients. ( 26134101 )
2015
13
Posterior Scleritis with Inflammatory Retinal Detachment. ( 26759674 )
2015
14
Optical coherence tomography in the management of posterior scleritis. ( 26265857 )
2015
15
A case of nodular posterior scleritis mimicking choroidal mass. ( 25892938 )
2015
16
NODULAR POSTERIOR SCLERITIS: Clinico-Sonographic Characteristics and Proposed Diagnostic Criteria. ( 26296144 )
2015
17
Bilateral Posterior Scleritis: Analysis of 18 Cases from a Large Cohort of Posterior Scleritis. ( 26471249 )
2015
18
Recurrent Unilateral Vogt-Koyanagi-Harada Disease with Posterior Scleritis. ( 26457043 )
2015
19
A case of giant nodular posterior scleritis mimicking choroidal malignancy. ( 26862098 )
2015
20
Nodular Posterior Scleritis Mimicking Choroidal Tumor in a Patient With Systemic Lupus Erythematous: A Case Report and Literature Review. ( 26692258 )
2015
21
An atypical case of bilateral posterior scleritis in a patient with chronic lymphocytic leukemia. ( 26257236 )
2015
22
Posterior scleritis with retinal pigment epithelium rip: an unusual presentation. ( 25523863 )
2014
23
Bilateral posterior scleritis as a presenting manifestation of giant cell arteritis: A case report. ( 25433749 )
2014
24
Choroidal observations in posterior scleritis using high-penetration optical coherence tomography. ( 24398712 )
2014
25
Bilateral Posterior Scleritis Presenting as the First Manifestation of Immunoglobulin A Nephropathy: Case Report and Review of the Literature. ( 25290901 )
2014
26
Enhanced depth imaging optical coherence tomography of the choroid in new-onset acute posterior scleritis. ( 23381654 )
2013
27
Enhanced depth imaging optical coherence tomography of the choroid in recurrent unilateral posterior scleritis. ( 22395202 )
2013
28
Clinical Features and Presentation of Posterior Scleritis: A Report of 31 Cases. ( 24131324 )
2013
29
Posterior scleritis in children: clinical features and treatment. ( 22137553 )
2012
30
Posterior scleritis presenting with angle closure glaucoma. ( 22439667 )
2012
31
Stellate neuroretinitis associated with posterior scleritis. ( 25390952 )
2012
32
Posterior scleritis in a 9-year-old boy: a case report. ( 25390705 )
2012
33
Combined anterior and posterior scleritis associated with central retinal vein occlusion: a case report. ( 22411459 )
2012
34
Fatal Pneumocystis jirovecii pneumonia following immunosuppressive therapy with rituximab and prednisolone for posterior scleritis. ( 21649871 )
2012
35
Pediatric posterior scleritis. ( 22749104 )
2012
36
Posterior scleritis resembling acute retinal necrosis syndrome. ( 25390725 )
2012
37
Adjunctive globe magnetic resonance imaging in the diagnosis of posterior scleritis. ( 21816252 )
2011
38
Nodular posterior scleritis mimicking choroidal metastasis: a report of two cases. ( 21760715 )
2011
39
Intravitreal bevacizumab (avastin) as an adjuvant for the treatment of posterior scleritis. ( 21860578 )
2011
40
Posterior scleritis in patients with systemic lupus erythematosus. ( 25390910 )
2010
41
Posterior scleritis mimicking orbital cellulitis. ( 20819053 )
2010
42
Bilateral posterior scleritis: an idiopathic painless presentation. ( 20932196 )
2010
43
Bilateral disc swelling associated with posterior scleritis. ( 20508658 )
2010
44
Posterior scleritis: a rare pediatric disorder. ( 19483139 )
2009
45
A case of atypical Cogan's syndrome with posterior scleritis and uveitis. ( 20020252 )
2009
46
Cluster-like headache caused by posterior scleritis. ( 19250284 )
2009
47
Necrobiotic xanthogranuloma masquerading as posterior scleritis. ( 18292782 )
2009
48
Posterior scleritis presenting with simultaneous branch retinal artery occlusion and exudative retinal detachment. ( 18617904 )
2009
49
Recurrent posterior scleritis and orbital myositis as extra-intestinal manifestations of Crohn's disease: Case report and systematic literature review. ( 21172235 )
2008
50
Optical coherence tomography findings in a child with posterior scleritis. ( 18988177 )
2008

Variations for Posterior Scleritis

Expression for Posterior Scleritis

Search GEO for disease gene expression data for Posterior Scleritis.

Pathways for Posterior Scleritis

GO Terms for Posterior Scleritis

Biological processes related to Posterior Scleritis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.16 TNF TNFRSF10A
2 extrinsic apoptotic signaling pathway GO:0097191 8.96 TNF TNFRSF10A
3 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 8.62 TNF TNFRSF10A

Sources for Posterior Scleritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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