Posterior Urethral Valve malady

Nephrological diseases, Fetal diseases categories

Summaries for Posterior Urethral Valve

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63Wikipedia, 32MalaCards
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Wikipedia:63 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards: Posterior Urethral Valve, also known as posterior urethral valves, is related to vesicoureteral reflux and urinary tract obstruction. An important gene associated with Posterior Urethral Valve is AGTR1 (angiotensin II receptor, type 1), and among its related pathways are Thromboxane signalling through TP receptor and A-beta Uptake & Degradation. The compounds norepinephrine and temocaprilat have been mentioned in the context of this disorder. Affiliated tissues include lung, and related mouse phenotypes are adipose tissue and muscle.

Aliases & Classifications for Posterior Urethral Valve

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60UMLS, 48Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Nephrological diseases

Aliases & Descriptions:

posterior urethral valve 48
posterior urethral valves 60

External Ids:

ICD10 via Orphanet26 Q64.2
SNOMED-CT via Orphanet57 253900005
UMLS via Orphanet61 C0238506, C0542520

Related Diseases for Posterior Urethral Valve

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Posterior Urethral Valve:

Diseases related to posterior urethral valve

Clinical Features for Posterior Urethral Valve

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Drugs & Therapeutics for Posterior Urethral Valve

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Posterior Urethral Valve

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Anatomical Context for Posterior Urethral Valve

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MalaCards organs/tissues related to Posterior Urethral Valve:


Animal Models for Posterior Urethral Valve or affiliated genes

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MGI Mouse Phenotypes related to Posterior Urethral Valve:

idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.1AGTR2, AGT, ACE, TGFB1
2MP:00053697.8ACE2, TGFB1, AGTR2, AGT
3MP:00053787.6AGTR2, TGFB1, AGT, AGTR1, ACE
4MP:00053677.3AGT, TGFB1, ACE2, ACE, AGTR1, AGTR2
5MP:00053857.2TGFB1, AGTR2, AGTR1, AGT, ACE, ACE2
6MP:00053767.2ACE, AGT, AGTR1, AGTR2, ACE2, TGFB1
7MP:00107687.0AGTR2, TGFB1, AGTR1, AGT, ACE2, ACE

Publications for Posterior Urethral Valve

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Genetic Variations for Posterior Urethral Valve

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Expression for genes affiliated with Posterior Urethral Valve

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Posterior Urethral Valve

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Pathways for genes affiliated with Posterior Urethral Valve

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53Reactome, 12EMD Millipore, 52R&D Systems, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Posterior Urethral Valve

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Posterior Urethral Valve according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2411.9AGTR2
2temocaprilat449.9AGTR1, ACE
3cv 11974449.8AGTR1, AGT
4remikiren44 1110.7AGT, ACE
5benazepril hydrochloride599.7ACE, ACE2
6moexipril hydrochloride599.7ACE, ACE2
7perindopril erbumine599.7ACE2, ACE
8superoxide44 2410.7AGTR1, AGT
9lacidipine449.7AGTR1, ACE
10moexipril44 1110.6ACE, ACE2
11angiotensin iii289.6AGTR1, AGTR2
12captopril44 28 49 59 1113.6AGTR2, ACE2
13etoperidone449.6AGTR1, AGTR2
14angiotensin i289.6AGTR1, AGTR2
15trandolapril44 1110.5ACE, AGTR1
16aliskiren44 1110.5AGT, ACE, AGTR1
17Tasosartan119.5AGTR1, AGTR2
18eprosartan44 28 1111.5AGTR1, ACE, AGT
19olmesartan44 28 1111.5AGTR1, AGT, ACE
20chymostatin449.5AGTR1, AGT, ACE
21atenolol44 28 49 11 2413.5AGTR1, AGT, ACE
22hydrochlorothiazide44 49 28 11 2413.5AGT, ACE, AGTR1
23diltiazem44 28 1111.4AGTR1, ACE, AGT
24amlodipine44 49 11 2412.4AGT, ACE, AGTR1
25eplerenone44 59 28 1112.4AGTR1, ACE, ACE2
26enalaprilat449.4ACE2, ACE, AGT
27nadph44 2410.3ACE2, AGTR2
28cilazapril44 1110.2ACE, AGTR1
29cgp42112a449.2AGTR2, AGTR1, AGT
30spironolactone49 44 59 28 1113.1AGTR2, AGTR1, ACE
31lisinopril44 11 2411.0ACE2, AGTR1, AGT, ACE
32benazepril44 119.9TGFB1, ACE, AGT, AGTR1
33perindopril44 49 1110.9ACE, AGTR1, AGT, TGFB1
34nifedipine44 49 28 1111.8AGT, TGFB1, AGTR1, ACE
35ramipril44 119.8AGTR1, ACE, ACE2, TGFB1
36verapamil44 49 28 11 2412.8ACE, TGFB1, AGTR1
37saralasin448.7AGT, ACE, AGTR2, AGTR1
38pd12331944 289.7AGTR2, AGTR1, ACE, AGT
39valsartan44 59 28 1111.7AGT, AGTR1, AGTR2, ACE
40telmisartan44 28 1110.7AGTR1, AGTR2, AGT, ACE
41irbesartan44 28 49 1111.7AGT, ACE, AGTR1, AGTR2
42enalapril44 49 1110.7AGTR1, AGTR2, ACE, AGT
43angiotensin ii28 249.6AGTR2, AGTR1, ACE2, ACE
44prostacyclin448.6ACE, AGT, AGTR2, AGTR1
45sodium44 249.3AGT, ACE, AGTR1, AGTR2
46candesartan44 28 1110.1AGTR2, TGFB1, ACE, AGT, AGTR1
47ang ii448.1AGTR1, AGT, ACE, AGTR2, TGFB1
48losartan44 49 28 1111.1ACE, TGFB1, AGT, AGTR1, AGTR2
49creatinine448.0TGFB1, AGTR2, ACE, AGT, AGTR1
50nitric oxide44 11 2410.0AGT, AGTR1, ACE, ACE2, AGTR2

GO Terms for genes affiliated with Posterior Urethral Valve

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16Gene Ontology
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Cellular components related to Posterior Urethral Valve according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4TGFB1, ACE2, ACE, AGT
2extracellular regionGO:0055767.2TGFB1, ACE2, ACE, AGT, AGTR2

Biological processes related to Posterior Urethral Valve according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.0AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.0AGT, AGTR1
3regulation of renal sodium excretionGO:03581310.0AGT, AGTR1
4positive regulation of cholesterol esterificationGO:0108739.9AGT, AGTR1
5regulation of renal output by angiotensinGO:0020199.9AGT, ACE
6low-density lipoprotein particle remodelingGO:0343749.9AGTR1, AGT
7angiotensin-mediated drinking behaviorGO:0030519.9ACE2, AGT
8positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGTR1, AGT
9angiotensin catabolic process in bloodGO:0020059.8ACE2, ACE
10positive regulation of superoxide anion generationGO:0329309.7AGT, TGFB1
11mononuclear cell proliferationGO:0329439.7ACE, TGFB1
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.7AGT, AGTR1
13regulation of inflammatory responseGO:0507279.7AGTR1, ACE2
14positive regulation of inflammatory responseGO:0507299.6AGT, AGTR1
15negative regulation of neurotrophin TRK receptor signaling pathwayGO:0513879.6AGT, AGTR2
16cellular sodium ion homeostasisGO:0068839.5AGT, AGTR2
17cell growth involved in cardiac muscle cell developmentGO:0610499.5AGT, AGTR2
18G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:0071999.5AGTR2, AGT
19positive regulation of reactive oxygen species metabolic processGO:20003799.5ACE2, AGTR1, AGT
20regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.4ACE2, AGTR1, ACE
21positive regulation of renal sodium excretionGO:0358159.4AGT, AGTR2
22regulation of vasodilationGO:0423129.4AGTR1, ACE, ACE2
23kidney developmentGO:0018229.4ACE, AGT, AGTR1
24nitric oxide mediated signal transductionGO:0072639.4AGTR2, AGT
25regulation of cell proliferationGO:0421279.4AGTR1, AGT, ACE2
26positive regulation of cellular protein metabolic processGO:0322709.4AGTR1, AGT, TGFB1
27angiotensin maturationGO:0020039.4ACE, ACE2, AGT
28positive regulation of extrinsic apoptotic signaling pathwayGO:20012389.4AGT, AGTR2
29cellular response to dexamethasone stimulusGO:0715499.3TGFB1, AGTR2
30regulation of cell growthGO:0015589.3AGT, AGTR1
31negative regulation of blood vessel endothelial cell migrationGO:0435379.3TGFB1, AGTR2
32renin-angiotensin regulation of aldosterone productionGO:0020189.2AGTR1, AGTR2, AGT
33blood vessel remodelingGO:0019749.1AGT, ACE, AGTR2
34regulation of blood pressureGO:0082179.0AGTR2, ACE
35regulation of vasoconstrictionGO:0192299.0ACE2, ACE, AGT, AGTR1
36positive regulation of branching involved in ureteric bud morphogenesisGO:0901909.0AGTR2, AGT, TGFB1
37G-protein coupled receptor signaling pathwayGO:0071868.9AGT, AGTR1, AGTR2
38negative regulation of cell growthGO:0303088.9TGFB1, AGTR2, AGT
39positive regulation of transcription, DNA-dependentGO:0458938.6AGTR2, TGFB1, AGT

Molecular functions related to Posterior Urethral Valve according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:0106989.8AGTR1, AGT
2bradykinin receptor bindingGO:0317119.7AGTR1, ACE
3peptidyl-dipeptidase activityGO:0082419.5ACE, ACE2
4carboxypeptidase activityGO:0041809.4ACE2, ACE
5metallopeptidase activityGO:0082379.4ACE, ACE2
6angiotensin type II receptor activityGO:0049459.3AGTR2, AGTR1
7endopeptidase activityGO:0041759.1ACE, ACE2
8peptide hormone bindingGO:0170469.0AGTR2, ACE2

Products for genes affiliated with Posterior Urethral Valve

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  • Antibodies
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Sources for Posterior Urethral Valve

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26ICD10 via Orphanet
35MESH via Orphanet
47OMIM via Orphanet
57SNOMED-CT via Orphanet
61UMLS via Orphanet