MCID: PST087
MIFTS: 47

Posterior Urethral Valve malady

Nephrological, Fetal categories

Summaries for Posterior Urethral Valve

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards: Posterior Urethral Valve, also known as posterior urethral valves, is related to vesicoureteral reflux and urinary tract obstruction. An important gene associated with Posterior Urethral Valve is AGTR1 (angiotensin II receptor, type 1), and among its related pathways are Thromboxane signalling through TP receptor and A-beta Uptake & Degradation. The compounds norepinephrine and temocaprilat have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and prostate, and related mouse phenotypes are adipose tissue and muscle.

Aliases & Classifications for Posterior Urethral Valve

Sources:
61UMLS, 49Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Nephrological


Aliases & Descriptions:

posterior urethral valve 49
posterior urethral valves 61


External Ids:

ICD10 via Orphanet26 Q64.2
SNOMED-CT via Orphanet58 253900005
UMLS via Orphanet62 C0238506, C0542520

Related Diseases for Posterior Urethral Valve

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Posterior Urethral Valve:



Diseases related to posterior urethral valve

Clinical Features for Posterior Urethral Valve

Drugs & Therapeutics for Posterior Urethral Valve

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Posterior Urethral Valve

Drug clinical trials:

Search ClinicalTrials for Posterior Urethral Valve

Search NIH Clinical Center for Posterior Urethral Valve

Search CenterWatch for Posterior Urethral Valve

Genetic Tests for Posterior Urethral Valve

Anatomical Context for Posterior Urethral Valve

Sources:
33MalaCards
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MalaCards organs/tissues related to Posterior Urethral Valve:

33
Kidney, Lung, Prostate

Animal Models for Posterior Urethral Valve or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Posterior Urethral Valve

Sources:
51PubMed
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Articles related to Posterior Urethral Valve:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
2
A case of Down syndrome with a posterior urethral valve. (23326062)
2012
3
Long-term bladder function followup in boys with posterior urethral valves: comparison of noninvasive vs invasive urodynamic studies. (22819111)
2012
4
Management of obstructive uropathy with cutaneous ureterostomy in posterior urethral valve. (22382237)
2012
5
Delayed presentation of posterior urethral valves in discordant twins. (22305421)
2012
6
Late presentation of posterior urethral valves. (21703052)
2011
7
Posterior urethral valves: relationship between vesicoureteral reflux and renal function. (21109298)
2011
8
Long-term upper and lower urinary tract functions in children with posterior urethral valves. (19679514)
2010
9
Posterior urethral valves: Morphological normalization of posterior urethra after fulguration is a significant factor in prognosis. (21124660)
2010
10
Posterior urethral valves: a single center experience over 7 years. (19184051)
2009
11
Abnormal antenatal sonogram: an indicator of disease severity in children with posterior urethral valves. (19632082)
2009
12
Mohan's valvotome for the ablation of posterior urethral valves. (19157989)
2009
13
Keyhole sign: how specific is it for the diagnosis of posterior urethral valves? (19642115)
2009
14
Early valve ablation can decrease the incidence of bladder dysfunction in boys with posterior urethral valves. (19692077)
2009
15
Transient urinary ascites after vesicocentesis observed in a fetus with megacystis caused by posterior urethral valve. (19349701)
2009
16
Posterior urethral valve associated with orthotopic ureterocele. (19468522)
2008
17
Posterior urethral valves: search for a diagnostic reference standard. (18585762)
2008
18
A rare case of posterior urethral valve and pleural effusion in Down syndrome with successful intrauterine shunt. (18936544)
2008
19
Re: The impact of late presentation of posterior urethral valves on bladder and renal function. O. Ziylan, T. Oktar, H. Ander, E. Korgali, H. Rodoplu and T. Kocak, J Urol, 175: 1894-1897, 2006. (17085214)
2006
20
Feeling good in daily life: from the point of view of boys with posterior urethral valves. (16945638)
2006
21
Re: the anatomy and embryology of posterior urethral valves. (17070329)
2006
22
Gene locus ambiguity in posterior urethral valves/prune-belly syndrome. (15912376)
2005
23
Bladder dysfunction as a prognostic factor in patients with posterior urethral valves. (12133070)
2002
24
Posterior urethral valves. (11294257)
2001
25
Bilateral high loop ureterostomy in the primary management of posterior urethral valves in a developing country. (11315276)
2001
26
Posterior urethral valves: failure of antenatal diagnosis. (11008610)
2000
27
Posterior urethral valves and the 11th Commandment. (10840449)
2000
28
Posterior urethral valves: inaccuracy of prenatal diagnosis. (9708443)
1998
29
Prenatal sonographic diagnosis of posterior urethral valves: identification of valves and thickening of the posterior urethral wall. (9719988)
1998
30
Progression to end-stage renal disease in children with posterior urethral valves. (9811384)
1998
31
Posterior urethral valves. (8813928)
1996
32
Posterior urethral valves in adults diagnosed by ultrasonography. (8705243)
1996
33
Renal transplantation in patients with posterior urethral valves: favorable long-term outcome. (7637074)
1995
34
Re: Delayed presentation of posterior urethral valves. S. A. Merchant et al. Br. J. Urol., 69, 318-319, 1992. (10071574)
1993
35
Laser treatment of posterior urethral valves in neonates. (1581816)
1992
36
Complications of transurethral electro-incision of posterior urethral valves. (2021825)
1991
37
Alternatives in the management of posterior urethral valves. (2186539)
1990
38
Posterior urethral valves causing urinary retention in an infant with duplication of the urethra. (6737596)
1984
39
Andrological implications of congenital posterior urethral valves in adults. A case of retained ejaculation and review in western literature. (6686141)
1983
40
Complications of posterior urethral valve surgery and their prevention. (6623740)
1983
41
Urethral strictures following transurethral resection of posterior urethral valves. (7087026)
1982
42
Treatment of posterior urethral valves by pressure necrosis. A complete study of 30 cases with follow-up. (7174088)
1982
43
Major and minor complications of posterior urethral valves. (7288943)
1981
44
Prevention of urethral strictures in the management of posterior urethral valves. (7299930)
1981
45
Endoscopic diagnosis of posterior urethral valves. (588717)
1977
46
A new dimension in the diagnosis of posterior urethral valves in children. (1113427)
1975
47
Neonatal "urinothorax" associated with posterior urethral valves. (5579179)
1971
48
Posterior urethral valves in adults. (5383557)
1969
49
Posterior urethral valves: diagnosis and management. (5378031)
1969
50
Congenital posterior urethral valves. (5931202)
1966

Genetic Variations for Posterior Urethral Valve

Expression for genes affiliated with Posterior Urethral Valve

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Posterior Urethral Valve

Search GEO for disease gene expression data for Posterior Urethral Valve.

Pathways for genes affiliated with Posterior Urethral Valve

Sources:
54Reactome, 12EMD Millipore, 53R&D Systems, 30KEGG, 50PharmGKB, 38NCBI BioSystems Database, 52QIAGEN
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Compounds for genes affiliated with Posterior Urethral Valve

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB
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Compounds related to Posterior Urethral Valve according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2411.9AGTR2
2temocaprilat459.9AGTR1, ACE
3cv 11974459.8AGTR1, AGT
4remikiren45 1110.8ACE, AGT
5benazepril hydrochloride609.7ACE, ACE2
6moexipril hydrochloride609.7ACE, ACE2
7perindopril erbumine609.7ACE, ACE2
8superoxide45 2410.7AGT, AGTR1
9lacidipine459.7AGTR1, ACE
10moexipril45 1110.6ACE, ACE2
11captopril45 29 50 60 1113.6AGTR2, ACE2
12etoperidone459.6AGTR1, AGTR2
13angiotensin i299.6AGTR1, AGTR2
14angiotensin iii299.6AGTR1, AGTR2
15cilazapril45 1110.5ACE, AGTR1
16aliskiren45 1110.5ACE, AGT, AGTR1
17eprosartan45 29 1111.5AGTR1, AGT, ACE
18olmesartan45 29 1111.5ACE, AGT, AGTR1
19Tasosartan119.5AGTR1, AGTR2
20chymostatin459.5ACE, AGT, AGTR1
21atenolol45 29 50 11 2413.5ACE, AGT, AGTR1
22hydrochlorothiazide45 50 29 11 2413.5ACE, AGT, AGTR1
23diltiazem45 29 1111.4AGTR1, AGT, ACE
24amlodipine45 50 11 2412.4AGTR1, AGT, ACE
25eplerenone45 60 29 1112.4ACE2, ACE, AGTR1
26enalaprilat459.4AGT, ACE, ACE2
27nadph45 2410.3ACE2, AGTR2
28trandolapril45 1110.2ACE, AGTR1
29cgp42112a459.2AGT, AGTR1, AGTR2
30spironolactone50 45 60 29 1113.1AGTR2, AGTR1, ACE
31lisinopril45 11 2411.0ACE2, ACE, AGT, AGTR1
32benazepril45 119.9AGTR1, AGT, ACE, TGFB1
33perindopril45 50 1110.9AGTR1, AGT, ACE, TGFB1
34nifedipine45 50 29 1111.8AGTR1, AGT, ACE, TGFB1
35ramipril45 119.8AGTR1, ACE, ACE2, TGFB1
36verapamil45 50 29 11 2412.8TGFB1, ACE, AGTR1
37saralasin458.7AGTR2, AGTR1, AGT, ACE
38pd12331945 299.7AGTR2, AGTR1, AGT, ACE
39valsartan45 60 29 1111.7AGTR2, AGTR1, AGT, ACE
40telmisartan45 29 1110.7AGTR2, AGTR1, AGT, ACE
41irbesartan45 29 50 1111.7AGTR2, AGTR1, AGT, ACE
42enalapril45 50 1110.7AGTR2, AGTR1, AGT, ACE
43angiotensin ii29 249.6AGTR2, AGTR1, ACE, ACE2
44prostacyclin458.6AGTR2, AGTR1, AGT, ACE
45sodium45 249.3AGTR2, AGTR1, AGT, ACE
46candesartan45 29 1110.1TGFB1, ACE, AGT, AGTR1, AGTR2
47ang ii458.1AGTR2, AGTR1, AGT, ACE, TGFB1
48losartan45 50 29 1111.1AGTR2, AGTR1, AGT, ACE, TGFB1
49creatinine458.0AGTR2, AGTR1, AGT, ACE, TGFB1
50nitric oxide45 11 2410.0AGTR2, AGTR1, AGT, ACE, ACE2

GO Terms for genes affiliated with Posterior Urethral Valve

Sources:
16Gene Ontology
See all sources

Cellular components related to Posterior Urethral Valve according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4TGFB1, ACE2, ACE, AGT
2extracellular regionGO:0055767.2TGFB1, ACE2, ACE, AGT, AGTR2

Biological processes related to Posterior Urethral Valve according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.0AGTR1, AGT
2regulation of blood vessel size by renin-angiotensinGO:00203410.0AGTR1, AGT
3regulation of renal sodium excretionGO:03581310.0AGTR1, AGT
4positive regulation of cholesterol esterificationGO:0108739.9AGT, AGTR1
5regulation of renal output by angiotensinGO:0020199.9AGT, ACE
6low-density lipoprotein particle remodelingGO:0343749.9AGT, AGTR1
7angiotensin-mediated drinking behaviorGO:0030519.9AGT, ACE2
8positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGT, AGTR1
9angiotensin catabolic process in bloodGO:0020059.8ACE, ACE2
10mononuclear cell proliferationGO:0329439.7ACE, TGFB1
11positive regulation of superoxide anion generationGO:0329309.7TGFB1, AGT
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.7AGTR1, AGT
13regulation of inflammatory responseGO:0507279.7AGTR1, ACE2
14positive regulation of inflammatory responseGO:0507299.6AGT, AGTR1
15cell growth involved in cardiac muscle cell developmentGO:0610499.6AGTR2, AGT
16negative regulation of neurotrophin TRK receptor signaling pathwayGO:0513879.6AGTR2, AGT
17cellular sodium ion homeostasisGO:0068839.5AGTR2, AGT
18G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:0071999.5AGT, AGTR2
19positive regulation of reactive oxygen species metabolic processGO:20003799.5AGTR1, AGT, ACE2
20regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.4ACE2, ACE, AGTR1
21positive regulation of renal sodium excretionGO:0358159.4AGT, AGTR2
22regulation of vasodilationGO:0423129.4AGTR1, ACE, ACE2
23kidney developmentGO:0018229.4AGTR1, AGT, ACE
24nitric oxide mediated signal transductionGO:0072639.4AGT, AGTR2
25regulation of cell proliferationGO:0421279.4AGTR1, AGT, ACE2
26positive regulation of cellular protein metabolic processGO:0322709.4AGTR1, AGT, TGFB1
27angiotensin maturationGO:0020039.4AGT, ACE, ACE2
28positive regulation of extrinsic apoptotic signaling pathwayGO:20012389.4AGTR2, AGT
29cellular response to dexamethasone stimulusGO:0715499.3TGFB1, AGTR2
30regulation of cell growthGO:0015589.3AGT, AGTR1
31negative regulation of blood vessel endothelial cell migrationGO:0435379.3AGTR2, TGFB1
32renin-angiotensin regulation of aldosterone productionGO:0020189.2AGTR2, AGTR1, AGT
33blood vessel remodelingGO:0019749.1ACE, AGT, AGTR2
34regulation of blood pressureGO:0082179.0AGTR2, ACE
35regulation of vasoconstrictionGO:0192299.0ACE2, ACE, AGT, AGTR1
36positive regulation of branching involved in ureteric bud morphogenesisGO:0901909.0TGFB1, AGT, AGTR2
37G-protein coupled receptor signaling pathwayGO:0071868.9AGT, AGTR1, AGTR2
38negative regulation of cell growthGO:0303088.9AGTR2, AGT, TGFB1
39positive regulation of transcription, DNA-dependentGO:0458938.6TGFB1, AGT, AGTR2

Molecular functions related to Posterior Urethral Valve according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:0106989.8AGT, AGTR1
2bradykinin receptor bindingGO:0317119.7ACE, AGTR1
3peptidyl-dipeptidase activityGO:0082419.5ACE2, ACE
4carboxypeptidase activityGO:0041809.4ACE, ACE2
5metallopeptidase activityGO:0082379.4ACE2, ACE
6angiotensin type II receptor activityGO:0049459.3AGTR1, AGTR2
7endopeptidase activityGO:0041759.1ACE2, ACE
8peptide hormone bindingGO:0170469.0ACE2, AGTR2

Products for genes affiliated with Posterior Urethral Valve

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Posterior Urethral Valve

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet