MCID: PST087
MIFTS: 52

Posterior Urethral Valve malady

Nephrological diseases, Fetal diseases, Rare diseases categories
Download this MalaCard

Summaries for Posterior Urethral Valve

About this section
Sources:
65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards: Posterior Urethral Valve, also known as posterior urethral valves, is related to vesicoureteral reflux and urinary tract obstruction. An important gene associated with Posterior Urethral Valve is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are Neuropeptides signaling through G protein alpha i and G protein alpha q and A-beta Plaque Formation and APP Metabolism. The compounds angiotensin i and angiotensin iii have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and prostate, and related mouse phenotypes are adipose tissue and muscle.

Aliases & Classifications for Posterior Urethral Valve

About this section
Sources:
62UMLS, 49Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases, Rare diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

posterior urethral valve 49
posterior urethral valves 62


External Ids:

ICD10 via Orphanet26 Q64.2
SNOMED-CT via Orphanet59 253900005
UMLS via Orphanet63 C0238506, C0542520

Related Diseases for Posterior Urethral Valve

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Posterior Urethral Valve:



Diseases related to posterior urethral valve

Symptoms for Posterior Urethral Valve

About this section

Drugs & Therapeutics for Posterior Urethral Valve

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Posterior Urethral Valve

Search NIH Clinical Center for Posterior Urethral Valve

Genetic Tests for Posterior Urethral Valve

About this section

Anatomical Context for Posterior Urethral Valve

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Posterior Urethral Valve:

33
Lung, Kidney, Prostate, Testes

Animal Models for Posterior Urethral Valve or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Posterior Urethral Valve:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.1AGT, AGTR2, ACE, TGFB1
2MP:00053698.0TGFB1, ACE2, AGTR2, AGT
3MP:00053787.6AGTR1, AGT, AGTR2, ACE, TGFB1
4MP:00053677.3AGTR1, AGT, AGTR2, ACE, ACE2, TGFB1
5MP:00053857.2TGFB1, ACE2, ACE, AGTR2, AGT, AGTR1
6MP:00053767.2TGFB1, ACE2, ACE, AGTR2, AGT, AGTR1
7MP:00107687.1TGFB1, ACE2, ACE, AGTR2, AGT, AGTR1

Publications for Posterior Urethral Valve

About this section
Sources:
52PubMed
See all sources

Articles related to Posterior Urethral Valve:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Renal Parenchymal Area and Risk of ESRD in Boys with Posterior Urethral Valves. (24311709)
2013
2
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
3
Posterior urethral valves: Persistent renin angiotensin system activation after valve ablation and role of pre-emptive therapy with angiotensin converting enzyme-inhibitors on renal recovery. (23798811)
2013
4
Utilization of computer enhanced visual learning (CEVL) method improves endoscopic diagnosis of posterior urethral valves (PUV). (22981142)
2013
5
A rare cause of ascites in a newborn: posterior urethral valve. (20158664)
2010
6
Etiopathogenesis and management of bladder dysfunction in patients with posterior urethral valves. (21369376)
2010
7
A follow-up study of children with posterior urethral valve. (20835319)
2010
8
Prognostic value of serum creatinine levels in children with posterior urethral valves treated by primary valve ablation. (19581129)
2010
9
Posterior urethral valves: a single center experience over 7 years. (19184051)
2009
10
Abnormal antenatal sonogram: an indicator of disease severity in children with posterior urethral valves. (19632082)
2009
11
Posterior urethral valves are often associated with cryptorchidism and inguinal hernias. (18554641)
2008
12
Concordant posterior urethral valves in male monochorionic twins with secondary prune belly syndrome. (19213520)
2008
13
Re: The effects of bladder neck incision on urodynamic abnormalities of children with posterior urethral valves. A. M. Kajbafzadeh, S. Payabvash and G. Karimian. J Urol 2007; 178: 2142-2149. (18436260)
2008
14
Posterior urethral valves in three siblings: a case report and review of the literature. (18240166)
2008
15
Renal transplantation in children with posterior urethral valves. (16491414)
2006
16
The impact of late presentation of posterior urethral valves on bladder and renal function. (16600793)
2006
17
Long-term followup of bilateral high (sober) urinary diversion in patients with posterior urethral valves and its effect on bladder function. (15821568)
2005
18
Myogenic bladder decompensation in boys with a history of posterior urethral valves is caused by secondary bladder neck obstruction? (15963137)
2005
19
Initial and long-term management of posterior urethral valves. (15558286)
2004
20
Long-term outcome of posterior urethral valves ablation using the Mohan's urethral valvotome. (15171523)
2004
21
Posterior urethral valves: prognostic factors. (12699486)
2003
22
Incidental adult posterior urethral valve without clinical features. (15072500)
2003
23
Posterior urethral valves and mirror image anomalies in monozygotic twins. (12210353)
2002
24
Xanthogranulomatous pyelonephritis in a dysplastic kidney with reflux associated with posterior urethral valves. (11832763)
2002
25
Prospective analysis of renal function and somatic growth in neonatal posterior urethral valves. (12369006)
2002
26
Posterior urethral valves. (12696266)
2002
27
Increased urinary transforming growth factor-beta(1) excretion in children with posterior urethral valves. (10925100)
2000
28
The long-term complications of posterior urethral valves. (10330919)
1999
29
Spontaneous resolution of an in utero perirenal urinoma associated with posterior urethral valves. (10754132)
1999
30
Applications of the KTP laser in the treatment of posterior urethral valves, ureteroceles, and urethral strictures in the pediatric patient. (9728129)
1998
31
The management of unilateral poorly functioning kidneys in patients with posterior urethral valves. (9258129)
1997
32
The long-term outcome of posterior urethral valves treated with primary valve ablation and observation. (8627873)
1996
33
Long-term bladder dysfunction in boys with posterior urethral valves. (8877354)
1996
34
Posterior urethral valves: a report of five cases. (7634189)
1995
35
Mercapto-acetyltriglycine (MAG 3) renography and indirect radionuclide cystography in posterior urethral valves. (7827852)
1994
36
Re: Delayed presentation of posterior urethral valves. S. A. Merchant et al. Br. J. Urol., 69, 318-319, 1992. (10071574)
1993
37
Unusual presentation of adult posterior urethral valve. (1422693)
1992
38
Re: Renal transplantation in children with posterior urethral valves. (1294129)
1992
39
Influence of initial therapy on progression of renal failure and body growth in children with posterior urethral valves. (1640516)
1992
40
99mTc DTPA scintigraphy compared with intravenous urography in the follow-up of posterior urethral valves. (3322473)
1987
41
Posterior urethral valves in Saudi Arabia. (3833844)
1985
42
Posterior urethral valves in the British Isles: a multicenter B.A.P.S. review. (6834230)
1983
43
Observations on persistently dilated ureter after posterior urethral valve ablation. (7112792)
1982
44
Major and minor complications of posterior urethral valves. (7288943)
1981
45
The protean aspects of posterior urethral valves. (7321118)
1981
46
Nursing care study - posterior urethral valves. A sick baby makes a fresh start. (6898045)
1980
47
Posterior urethral valves. (588718)
1977
48
Posterior urethral valves in siblings. (1268469)
1976
49
3 case reports of posterior urethral valves with varied presentations. (1021125)
1976
50
Obstructive posterior urethral valves: the light at the end of the tunnel. (1113426)
1975

Variations for Posterior Urethral Valve

About this section

Expression for genes affiliated with Posterior Urethral Valve

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Posterior Urethral Valve

Search GEO for disease gene expression data for Posterior Urethral Valve.

Pathways for genes affiliated with Posterior Urethral Valve

About this section
Sources:
50PathCards, 12EMD Millipore, 38NCBI BioSystems Database, 54R&D Systems, 55Reactome, 30KEGG, 53QIAGEN, 51PharmGKB
See all sources

Pathways related to Posterior Urethral Valve according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Peptide GPCRs38
9.5AGTR1, AGTR2
29.3ACE, ACE2
39.3ACE, ACE2
49.2TGFB1, AGT
5
Show member pathways
9.1AGTR2, AGT, AGTR1
6
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.0ACE, TGFB1
7
Show member pathways
8.9AGT, ACE, ACE2
8
Show member pathways
8.9AGT, ACE, ACE2
9
Show member pathways
8.8TGFB1, AGTR2, AGT
10
Show member pathways
8.3AGTR1, AGT, AGTR2, TGFB1
11
Show member pathways
8.3TGFB1, AGTR2, AGT, AGTR1
12
Show member pathways
7.6TGFB1, ACE, AGTR2, AGT, AGTR1
13
Show member pathways
7.1AGTR1, AGT, AGTR2, ACE, ACE2, TGFB1

Compounds for genes affiliated with Posterior Urethral Valve

About this section
Sources:
29IUPHAR, 45Novoseek, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 24HMDB
See all sources

Compounds related to Posterior Urethral Valve according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1angiotensin i299.8AGTR2, AGTR1
2angiotensin iii299.8AGTR2, AGTR1
3etoperidone459.8AGTR1, AGTR2
4perindopril erbumine619.7ACE2, ACE
5benazepril hydrochloride619.7ACE, ACE2
6cv 11974459.6AGTR1, AGT
7moexipril hydrochloride619.6ACE2, ACE
8remikiren45 1110.6AGT, ACE
9temocaprilat459.6AGTR1, ACE
10moexipril45 1110.5ACE, ACE2
11cgp42112a459.5AGTR1, AGT, AGTR2
12lacidipine459.3ACE, AGTR1
13aliskiren45 1110.3AGT, ACE, AGTR1
14eprosartan45 29 1111.3ACE, AGT, AGTR1
15spironolactone45 61 29 51 1113.3AGTR1, ACE, AGTR2
16olmesartan45 29 1111.3ACE, AGT, AGTR1
17enalaprilat459.3AGT, ACE, ACE2
18chymostatin459.3ACE, AGTR1, AGT
19atenolol45 51 29 24 1113.2ACE, AGTR1, AGT
20diltiazem45 29 51 1112.2ACE, AGT, AGTR1
21hydrochlorothiazide45 29 51 24 1113.2AGTR1, ACE, AGT
22amlodipine45 51 24 1112.2ACE, AGT, AGTR1
23eplerenone45 61 29 1112.2AGTR1, ACE2, ACE
24cgmp45 2910.1AGTR2, AGTR1, AGT
25saralasin458.9ACE, AGT, AGTR1, AGTR2
26pd12331945 299.9ACE, AGTR1, AGT, AGTR2
27valsartan45 61 29 1111.9AGT, ACE, AGTR2, AGTR1
28telmisartan45 29 1110.9AGTR1, ACE, AGTR2, AGT
29irbesartan45 29 51 1111.9AGTR2, AGT, AGTR1, ACE
30enalapril45 51 1110.9ACE, AGTR1, AGT, AGTR2
31angiotensin ii29 249.8ACE2, ACE, AGTR2, AGTR1
32prostacyclin458.8AGTR1, AGT, AGTR2, ACE
33nadph45 249.8ACE2, AGTR1, AGT, AGTR2
34lisinopril45 51 24 1111.8AGTR1, AGT, ACE2, ACE
35norepinephrine45 24 1110.7AGTR1, AGTR2, AGT, ACE
36superoxide45 249.7ACE2, AGT, AGTR2, AGTR1
37sodium45 249.5ACE, AGTR2, AGT, AGTR1
38benazepril45 51 1110.5TGFB1, ACE, AGT, AGTR1
39perindopril45 51 1110.5TGFB1, AGT, AGTR1, ACE
40cyclosporin a45 29 6110.5AGT, AGTR2, TGFB1, AGTR1
41nifedipine45 29 51 1111.4AGT, TGFB1, ACE, AGTR1
42ramipril45 119.4TGFB1, ACE2, ACE, AGTR1
43verapamil45 29 51 24 1112.4AGTR1, ACE, TGFB1
44captopril45 61 51 29 1112.4AGTR1, ACE, AGTR2, AGT, ACE2
45nitric oxide45 24 1110.3AGTR2, AGT, ACE, AGTR1, ACE2
46candesartan45 51 29 1111.1AGTR1, AGTR2, ACE, AGT, TGFB1
47ang ii458.1ACE, TGFB1, AGTR2, AGT, AGTR1
48losartan45 51 29 1111.1TGFB1, AGTR2, AGTR1, AGT, ACE
49cholesterol45 29 24 1111.1AGTR1, ACE2, ACE, AGT
50creatinine458.0AGT, AGTR1, ACE, TGFB1, AGTR2

GO Terms for genes affiliated with Posterior Urethral Valve

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Posterior Urethral Valve according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.8TGFB1, ACE2, ACE, AGT
2plasma membraneGO:0058867.6AGTR1, AGTR2, ACE, ACE2, TGFB1
3extracellular regionGO:0055767.5AGT, AGTR2, ACE, ACE2, TGFB1

Biological processes related to Posterior Urethral Valve according to GeneCards/GeneDecks:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1cell growth involved in cardiac muscle cell developmentGO:06104910.0AGT, AGTR2
2negative regulation of neurotrophin TRK receptor signaling pathwayGO:05138710.0AGTR2, AGT
3cellular sodium ion homeostasisGO:00688310.0AGTR2, AGT
4G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:0071999.9AGT, AGTR2
5angiotensin-activated signaling pathwayGO:0381669.9AGTR2, AGTR1
6positive regulation of NAD(P)H oxidase activityGO:0338649.9AGTR1, AGT
7positive regulation of renal sodium excretionGO:0358159.9AGTR2, AGT
8angiotensin-mediated drinking behaviorGO:0030519.9ACE2, AGT
9regulation of blood vessel size by renin-angiotensinGO:0020349.9AGT, AGTR1
10regulation of renal sodium excretionGO:0358139.9AGT, AGTR1
11nitric oxide mediated signal transductionGO:0072639.9AGT, AGTR2
12positive regulation of extrinsic apoptotic signaling pathwayGO:20012389.9AGTR2, AGT
13positive regulation of cholesterol esterificationGO:0108739.8AGT, AGTR1
14regulation of renal output by angiotensinGO:0020199.8AGT, ACE
15low-density lipoprotein particle remodelingGO:0343749.8AGTR1, AGT
16positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGTR1, AGT
17angiotensin catabolic process in bloodGO:0020059.7ACE2, ACE
18phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.7AGTR1, AGT
19positive regulation of inflammatory responseGO:0507299.7AGT, AGTR1
20regulation of inflammatory responseGO:0507279.6ACE2, AGTR1
21regulation of blood pressureGO:0082179.6AGTR2, ACE
22cellular response to dexamethasone stimulusGO:0715499.6TGFB1, AGTR2
23positive regulation of superoxide anion generationGO:0329309.5TGFB1, AGT
24negative regulation of blood vessel endothelial cell migrationGO:0435379.5AGTR2, TGFB1
25renin-angiotensin regulation of aldosterone productionGO:0020189.5AGTR1, AGT, AGTR2
26mononuclear cell proliferationGO:0329439.4ACE, TGFB1
27regulation of cell growthGO:0015589.4AGT, AGTR1
28blood vessel remodelingGO:0019749.4ACE, AGTR2, AGT
29positive regulation of reactive oxygen species metabolic processGO:20003799.4AGTR1, AGT, ACE2
30regulation of cell proliferationGO:0421279.3AGTR1, AGT, ACE2
31G-protein coupled receptor signaling pathwayGO:0071869.3AGTR1, AGT, AGTR2
32angiotensin maturationGO:0020039.3ACE2, ACE, AGT
33regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.2ACE2, ACE, AGTR1
34kidney developmentGO:0018229.2AGTR1, AGT, ACE
35regulation of vasodilationGO:0423129.2AGTR1, ACE, ACE2
36positive regulation of branching involved in ureteric bud morphogenesisGO:0901909.2TGFB1, AGTR2, AGT
37positive regulation of NF-kappaB transcription factor activityGO:0510929.2AGT, TGFB1
38negative regulation of cell growthGO:0303089.1AGT, AGTR2, TGFB1
39positive regulation of cellular protein metabolic processGO:0322709.1TGFB1, AGT, AGTR1
40agingGO:0075688.9AGT, TGFB1
41cellular protein metabolic processGO:0442678.9AGT, ACE, ACE2
42positive regulation of transcription, DNA-templatedGO:0458938.9TGFB1, AGTR2, AGT
43regulation of vasoconstrictionGO:0192298.8AGTR1, AGT, ACE, ACE2

Molecular functions related to Posterior Urethral Valve according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:0049459.6AGTR1, AGTR2
2bradykinin receptor bindingGO:0317119.5AGTR1, ACE
3peptidyl-dipeptidase activityGO:0082419.4ACE, ACE2
4peptide hormone bindingGO:0170469.4AGTR2, ACE2
5carboxypeptidase activityGO:0041809.3ACE2, ACE
6metallopeptidase activityGO:0082379.3ACE, ACE2
7endopeptidase activityGO:0041759.0ACE, ACE2

Products for genes affiliated with Posterior Urethral Valve

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Posterior Urethral Valve

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet