MCID: PST041
MIFTS: 46

Posterior Urethral Valves malady

Categories: Rare diseases, Nephrological diseases, Fetal diseases

Aliases & Classifications for Posterior Urethral Valves

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Sources:
46NIH Rare Diseases, 52Orphanet, 66UMLS, 29ICD10 via Orphanet, 67UMLS via Orphanet, 28ICD10
See all MalaCards sources

Aliases & Descriptions for Posterior Urethral Valves:

Name: Posterior Urethral Valves 46
Congenital Posterior Urethral Valves 66
 
Posterior Urethral Valve 52
Puv 52

Characteristics:

Orphanet epidemiological data:

52
posterior urethral valve:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Australia); Age of onset: Antenatal,Neonatal; Age of death: early childhood

Classifications:



External Ids:

Orphanet52 ORPHA93110
ICD10 via Orphanet29 Q64.2
UMLS via Orphanet67 C0238506, C0542520
ICD1028 Q64.2

Summaries for Posterior Urethral Valves

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Wikipedia:69 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards based summary: Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to congenital anomalies of kidney and urinary tract and urinary tract obstruction. An important gene associated with Posterior Urethral Valves is ACE (Angiotensin I Converting Enzyme), and among its related pathways are A-beta Pathways: Plaque Formation and APP Metabolism and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include lung, kidney and prostate, and related mouse phenotypes are neoplasm and muscle.

Related Diseases for Posterior Urethral Valves

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Diseases in the Anterior Urethral Valve family:

posterior urethral valves

Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1congenital anomalies of kidney and urinary tract31.5DSTYK, TBX18
2urinary tract obstruction30.5AGTR1, AGTR2, TGFB1
3sinusitis30.0ACE, TGFB1, TNF
4pyelonephritis29.1ACE, AGT, IL6, TNF
5urethritis11.2
6pediatric ulcerative colitis10.6ACE, AGT
7vesicoureteral reflux10.5
8familial hypopituitarism10.4AGT, AGTR1
9voyeurism10.4ACE, AGTR2
10chronic diarrhea due to guanylate cyclase 2c overactivity10.4ACE, IL6
11uveoparotid fever10.4ACE, TNF
12acneiform dermatitis10.4ACE, TNF
13broad ligament malignant neoplasm10.4ACE, AGTR1
14vibrio vulnificus infection10.4IL6, TGFB1
15hypopigmentation of eyelid10.4ACE, AGTR1, TGFB1
16prune belly syndrome10.3
17fatal infantile hypertrophic cardiomyopathy due to mitochondrial complex i deficiency10.3ACE, AGTR2, TGFB1
18marchiafava bignami disease10.3ACE, IL6
19parsonage turner syndrome10.3TGFB1, TNF
20myopathy-growth delay-intellectual disability-hypospadias syndrome10.3TGFB1, TNF
21pneumoconiosis due to talc10.3TGFB1, TNF
22podder-tolmie syndrome10.3AGT, AGTR1
23ovarian cancer10.3ACE, AGT, AGTR1
24casr-related disorders10.3ACE, AGT, AGTR1
25antiphospholipid syndrome10.3ACE, AGT, AGTR1
26chylocele of tunica vaginalis10.3ACE, AGT, AGTR1
27aortic valves stenosis of the child10.3ACE, AGT, AGTR1
28down syndrome10.3
29irritable bowel syndrome10.3ACE, AGT, AGTR1
30benign hypertensive renal disease10.3ACE, AGT, AGTR1
31renal tubular dysgenesis10.2ACE, AGT, AGTR1
32joint disorders10.2ACE, AGT, AGTR1
33collecting duct carcinoma10.2ACE, AGT, AGTR1
34addison's disease10.2TGFB1, TNF
35herpetic gastritis10.2ACE, AGT, AGTR1
36pelviureteric junction obstruction10.2
37urethral stricture10.2
38renal dysplasia10.2
39panner disease10.2IL6, TNF
40aortic arch interruption10.2IL6, TNF
41cutaneous leishmaniasis10.1IL6, TNF
42congenital methemoglobinemia10.1AGTR1, IL6, TGFB1
43maligant granulosa cell tumor of ovary10.1IL6, TNF
44hemometra10.1IL6, TNF
45burns10.1ACE, TGFB1, TNF
46tricho odonto onycho dermal syndrome10.1IL6, TNF
47imperforate anus10.1
48orchitis10.1
49ureterocele10.1
50kidney disease10.1

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Symptoms for Posterior Urethral Valves

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Drugs & Therapeutics for Posterior Urethral Valves

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Drugs for Posterior Urethral Valves (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PancuroniumPhase 2315500-66-027350, 441289
Synonyms:
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(1-methylpiperidinium-1-yl)androstane dibromide
1,1'-(3,17-Bis(acetyloxy)androstane-2,16-diyl)bis(1-methylpiperidinium) dibromide
1,1'-(3alpha,17beta-Bis(acetyloxy)-5alpha-androstane-2beta,16beta-diyl)bis(1-methylpiperidinium) dibromide
1,1'-(3alpha,17beta-Dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methylpiperidinium) dibromide diacetate
1,1'-([2beta,3alpha,5alpha,16beta,17beta]-3,17-Bis[acetyloxy]androstane-2,16-diyl)bis(1-methylpiperidinium) dibromide
1,1'-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide
15500-66-0
2beta,16beta-Dipiperidino-5alpha-androstane-3alpha,17beta-diol diacetate dimethobromide
2beta,16beta-Dipiperidino-5alpha-androstane-3alpha,17beta-dioldiacetatedimethobromide
3-alpha,17-beta-Diacetoxy-2-beta,16-beta-dipiperidino-5-alpha-androstane dimethobromide
3alpha,17beta-Diacetoxy-2beta,16beta-dipiperidino-5alpha-androstane dimethobromide
3alpha,17beta-diacetoxy-2beta,16beta-bis(1-methylpiperidinium-1-yl)-5alpha-androstane
3alpha,17beta-diacetoxy-2beta,16beta-bis(1-methylpiperidinium-1-yl)-5alpha-androstane dibromide
5alpha-Androstan-3alpha,17beta-diol, 2beta,16beta-dipipecolinio-, dibromide, diacetate
AB00384328
AC1L1D1A
AC1L9AWJ
Ambap15500-66-0
BPBio1_001372
BSPBio_001247
Bromure de pancuronium
Bromure de pancuronium [INN-French]
Bromure de pancuronium [inn-french]
Bromuro de pancuronio
Bromuro de pancuronio [INN-Spanish]
Bromuro de pancuronio [inn-spanish]
C07551
C35H60N2O4
CHEBI:7907
CHEBI:7908
CHEMBL1200757
CHEMBL185073
CID27350
CID441289
D00492
DB01337
EINECS 239-532-5
EU-0100887
HMS1571O09
HMS2089M07
 
HSDB 3244
LS-116480
Lopac0_000887
Mioblock
MolPort-003-938-961
NA 97
NCGC00023037-03
NCGC00023037-04
NCGC00023037-05
NSC 293162
NSC293162
ORG NA 97
ORG-NA 97
P 1918
P1918_SIGMA
PANCURONIUM BROMIDE
Pancuronii bromidum
Pancuronii bromidum [INN-Latin]
Pancuronium
Pancuronium bromide
Pancuronium bromide (JP15/USAN/INN)
Pancuronium bromide [USAN:BAN:INN:JAN]
Pancuronium dibromide
Pavulon
Pavulon (TN)
Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl)-, dibromide
Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl-, dibromide
Piperidinium, 1,1'-(2-beta,16-beta-(3-alpha,17-beta-dihydroxy-5-alpha-androstanylene))bis(1-methyl-, dibromide, diacetate
Piperidinium, 1,1'-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methyl-, dibromide, diacetate
Piperidinium, 1,1'-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methyl-, dibromide, diacetate (8CI)
Piperidinium, 1,1'-[(2.beta.,3.alpha.,5.alpha.,16.beta.,17.beta.)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide
Poncuronium bromide
Prestwick0_001034
Prestwick1_001034
Prestwick2_001034
Prestwick3_001034
S2497_Selleck
SPBio_003098
UNII-U9LY9Y75X2
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate dibromide
pancuronium
2
FentanylPhase 2739437-38-73345
Synonyms:
1-Phenethyl-4-(N-phenylpropionamido)piperidine
1-Phenethyl-4-N-propionylanilinopiperidine
437-38-7
5-22-08-00049 (Beilstein Handbook Reference)
80832-90-2
990-73-8 (citrate)
AC1L1FQ2
Actiq
BIDD:GT0555
BRN 0494484
CHEBI:119915
CHEMBL596
CID3345
D00320
DB00813
Duragesic
Duragesic (TN)
Duragesic-100
Duragesic-12
Duragesic-25
Duragesic-50
Duragesic-75
Durogesic
EINECS 207-113-6
Fentanest
Fentanil
Fentanil [DCIT]
Fentanila
Fentanila [INN-Spanish]
Fentanilo
Fentanyl
Fentanyl (JAN/USAN/INN)
Fentanyl [INN:BAN]
Fentanyl citrate
Fentanyl-100
 
Fentanyl-12
Fentanyl-25
Fentanyl-50
Fentanyl-75
Fentanylum
Fentanylum [INN-Latin]
HSDB 3329
IONSYS
JNS020QD
L001275
LS-124439
Matrifen
MolPort-003-847-369
N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-Phenethyl-4-piperidyl)propionanilide
N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide
N-Phenethyl-4-(N-propionylanilino)piperidine
N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
NCGC00168252-01
Nasalfent
Oprea1_152073
Oprea1_207148
PDSP1_000860
PDSP2_000846
Pentanyl
Phentanyl
Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)
R 4263
Rapinyl
Sentonil
Sublimase
Sublimaze
UNII-UF599785JZ
fentanyl

Interventional clinical trials:

idNameStatusNCT IDPhase
1Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract ObstructionsNot yet recruitingNCT01552824Phase 2
2Fetal Cystoscopy for Lower Urinary Tract ObstructionRecruitingNCT02446184Phase 1
3CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral ValvesRecruitingNCT01537601
4Standardized Prenatal Clinical Care for LUTORecruitingNCT02315521

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

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Anatomical Context for Posterior Urethral Valves

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MalaCards organs/tissues related to Posterior Urethral Valves:

34
Lung, Kidney, Prostate, Testes, Spinal cord

Animal Models for Posterior Urethral Valves or affiliated genes

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MGI Mouse Phenotypes related to Posterior Urethral Valves:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ACE, AGTR2, IL6, TGFB1, TNF
2MP:00053697.6ACE2, AGT, AGTR2, IL6, TBX18, TGFB1
3MP:00053876.9ACE, ACE2, AGT, AGTR1, IL6, SLC3A1
4MP:00053756.8ACE, AGT, AGTR1, AGTR2, IL6, SLC3A1
5MP:00053856.8ACE, ACE2, AGT, AGTR1, AGTR2, IL6
6MP:00053676.5ACE, ACE2, AGT, AGTR1, AGTR2, IL6
7MP:00053766.1ACE, ACE2, AGT, AGTR1, AGTR2, IL6
8MP:00107686.0ACE, ACE2, AGT, AGTR1, AGTR2, IL6
9MP:00053785.5ACE, ACE2, AGT, AGTR1, AGTR2, IL6

Publications for Posterior Urethral Valves

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Articles related to Posterior Urethral Valves:

(show top 50)    (show all 546)
idTitleAuthorsYear
1
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
2
Posterior urethral valves: Persistent renin angiotensin system activation after valve ablation and role of pre-emptive therapy with angiotensin converting enzyme-inhibitors on renal recovery. (23798811)
2013
3
Efficacy of bladder neck incision on urodynamic abnormalities in patients with posterior urethral valves. (23417544)
2013
4
A case of Down syndrome with a posterior urethral valve. (23326062)
2012
5
Posterior urethral valve: delayed presentation in adolescence. (23094222)
2012
6
Posterior urethral valves: long-term outcome. (21748651)
2011
7
Timing of posterior urethral valve diagnosis and its impact on clinical outcome. (20829118)
2011
8
A rare cause of ascites in a newborn: posterior urethral valve. (20158664)
2010
9
Posterior urethral valves: a single center experience over 7 years. (19184051)
2009
10
Outcome of endoscopic fulguration of posterior urethral valves in children. (19623154)
2009
11
Vesicoureteral reflux in conjunction with posterior urethral valves. (19683736)
2009
12
Re: The effects of bladder neck incision on urodynamic abnormalities of children with posterior urethral valves. A. M. Kajbafzadeh, S. Payabvash and G. Karimian. J Urol 2007; 178: 2142-2149. (18436260)
2008
13
Posterior urethral valves in three siblings: a case report and review of the literature. (18240166)
2008
14
A review of urodynamic evaluation in children and its role in the management of boys with posterior urethral valves. (19718301)
2007
15
Vesicostomy vs primary ablation for posterior urethral valves: always a difference in outcome? (18947754)
2007
16
The impact of late presentation of posterior urethral valves on bladder and renal function. (16600793)
2006
17
Re: The impact of late presentation of posterior urethral valves on bladder and renal function. O. Ziylan, T. Oktar, H. Ander, E. Korgali, H. Rodoplu and T. Kocak, J Urol, 175: 1894-1897, 2006. (17085214)
2006
18
Posterior urethral valves in patients with Down syndrome. (16186689)
2005
19
Initial and long-term management of posterior urethral valves. (15558286)
2004
20
Posterior urethral valves: prognostic factors. (12699486)
2003
21
Incidental adult posterior urethral valve without clinical features. (15072500)
2003
22
Posterior urethral valves and mirror image anomalies in monozygotic twins. (12210353)
2002
23
Prospective analysis of renal function and somatic growth in neonatal posterior urethral valves. (12369006)
2002
24
Posterior urethral valves causing urinomas: two case reports. (11966598)
2002
25
Posterior urethral valves. (11294257)
2001
26
Does neonatal pyeloureterostomy worsen bladder function in children with posterior urethral valves? (10958734)
2000
27
Does treatment of bladder dysfunction prior to renal transplant improve outcome in patients with posterior urethral valves? (11272604)
2000
28
Posterior urethral valves after infancy-urodynamic consequences. (9716680)
1998
29
Posterior urethral valves presenting as post-ejaculatory dysuria in a 29-year-old physician. (9628623)
1998
30
The long-term outcome of posterior urethral valves treated with primary valve ablation and observation. (8627873)
1996
31
Posterior urethral valves: a report of five cases. (7634189)
1995
32
Mercapto-acetyltriglycine (MAG 3) renography and indirect radionuclide cystography in posterior urethral valves. (7827852)
1994
33
Type III posterior urethral valves: presentation and management. (8120770)
1994
34
Re: Delayed presentation of posterior urethral valves. S. A. Merchant et al. Br. J. Urol., 69, 318-319, 1992. (10071574)
1993
35
Posterior urethral valves. Does prenatal diagnosis influence prognosis? (8080495)
1993
36
Re: Renal transplantation in children with posterior urethral valves. (1294129)
1992
37
Influence of initial therapy on progression of renal failure and body growth in children with posterior urethral valves. (1640516)
1992
38
Laser treatment of posterior urethral valves in neonates. (1581816)
1992
39
Alternatives in the management of posterior urethral valves. (2186539)
1990
40
99mTc DTPA scintigraphy compared with intravenous urography in the follow-up of posterior urethral valves. (3322473)
1987
41
An antegrade technique for ablation of posterior urethral valves. (6492291)
1984
42
Posterior urethral valves causing urinary retention in an infant with duplication of the urethra. (6737596)
1984
43
Congenital posterior urethral valves: problems of management in countries with limited facilities. (6200066)
1983
44
The variable effect of posterior urethral valves as illustrated in identical twins. (6685777)
1983
45
Urethral strictures following transurethral resection of posterior urethral valves. (7087026)
1982
46
Major and minor complications of posterior urethral valves. (7288943)
1981
47
The protean aspects of posterior urethral valves. (7321118)
1981
48
Renal hypoplasia and dysplasia in infants with posterior urethral valves. (7189794)
1980
49
Upper tract management when posterior urethral valve ablation is insufficient. (470011)
1979
50
Obstructive posterior urethral valves: the light at the end of the tunnel. (1113426)
1975

Variations for Posterior Urethral Valves

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Expression for genes affiliated with Posterior Urethral Valves

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Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for genes affiliated with Posterior Urethral Valves

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Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathwaysScoreTop Affiliating Genes
19.7ACE, ACE2
29.6IL6, TGFB1
39.5TGFB1, TNF
49.4ACE, AGT, AGTR1
59.3IL6, TNF
6
Show member pathways
9.2ACE, ACE2, AGT
79.1AGT, TGFB1, TNF
89.0IL6, TGFB1, TNF
99.0IL6, TGFB1, TNF
109.0IL6, TGFB1, TNF
11
Show member pathways
9.0IL6, TGFB1, TNF
129.0IL6, TGFB1, TNF
139.0IL6, TGFB1, TNF
149.0IL6, TGFB1, TNF
159.0IL6, TGFB1, TNF
169.0IL6, TGFB1, TNF
179.0IL6, TGFB1, TNF
18
Show member pathways
8.7ACE, IL6, TGFB1, TNF
198.6AGTR1, IL6, TGFB1, TNF
208.5AGT, IL6, TGFB1, TNF
21
Show member pathways
8.1ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
22
Show member pathways
8.1ACE, ACE2, AGT, AGTR1, AGTR2, TGFB1
23
Show member pathways
7.7AGT, AGTR1, AGTR2, IL6, TGFB1, TNF

GO Terms for genes affiliated with Posterior Urethral Valves

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Cellular components related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.7ACE, ACE2, AGT, IL6, TGFB1, TNF
2extracellular regionGO:00055767.0ACE, ACE2, AGT, AGTR2, IL6, TGFB1

Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:003294310.5ACE, TGFB1
2regulation of renal output by angiotensinGO:000201910.5ACE, AGT
3angiotensin catabolic process in bloodGO:000200510.4ACE, ACE2
4G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:000719910.3AGT, AGTR2
5negative regulation of neurotrophin TRK receptor signaling pathwayGO:005138710.3AGT, AGTR2
6regulation of blood vessel size by renin-angiotensinGO:000203410.3AGT, AGTR1
7positive regulation of cholesterol esterificationGO:001087310.3AGT, AGTR1
8angiotensin-activated signaling pathwayGO:003816610.3AGTR1, AGTR2
9cellular sodium ion homeostasisGO:000688310.2AGT, AGTR2
10cell growth involved in cardiac muscle cell developmentGO:006104910.2AGT, AGTR2
11low-density lipoprotein particle remodelingGO:003437410.2AGT, AGTR1
12regulation of renal sodium excretionGO:003581310.2AGT, AGTR1
13angiotensin-mediated drinking behaviorGO:000305110.2ACE2, AGT
14positive regulation of superoxide anion generationGO:003293010.2AGT, TGFB1
15positive regulation of mononuclear cell migrationGO:007167710.2TGFB1, TNF
16positive regulation of NAD(P)H oxidase activityGO:003386410.1AGT, AGTR1
17positive regulation of macrophage derived foam cell differentiationGO:001074410.1AGT, AGTR1
18neutrophil mediated immunityGO:000244610.1ACE, IL6
19positive regulation of gap junction assemblyGO:190359810.1ACE2, AGT
20positive regulation of protein complex assemblyGO:003133410.1TGFB1, TNF
21regulation of systemic arterial blood pressure by renin-angiotensinGO:000308110.0ACE, ACE2, AGTR1
22positive regulation of chemokine productionGO:003272210.0IL6, TNF
23receptor biosynthetic processGO:003280010.0ACE2, TNF
24epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.0IL6, TNF
25nitric oxide mediated signal transductionGO:000726310.0AGT, AGTR2
26negative regulation of blood vessel endothelial cell migrationGO:004353710.0AGTR2, TGFB1
27regulation of vasodilationGO:004231210.0ACE, ACE2, AGTR1
28renin-angiotensin regulation of aldosterone productionGO:00020189.9AGT, AGTR1, AGTR2
29positive regulation of branching involved in ureteric bud morphogenesisGO:00901909.9AGT, AGTR2, TGFB1
30negative regulation of lipid storageGO:00108889.8IL6, TNF
31positive regulation of cellular protein metabolic processGO:00322709.8AGT, AGTR1, TGFB1
32negative regulation of myoblast differentiationGO:00456629.8TGFB1, TNF
33angiotensin maturationGO:00020039.7ACE, ACE2, AGT
34kidney developmentGO:00018229.7ACE, AGT, AGTR1
35positive regulation of reactive oxygen species metabolic processGO:20003799.7ACE2, AGT, AGTR1
36regulation of blood pressureGO:00082179.6ACE, AGT, AGTR2
37positive regulation of renal sodium excretionGO:00358159.6AGT, AGTR2
38positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6AGT, IL6, TGFB1
39blood vessel remodelingGO:00019749.5ACE, AGT, AGTR2
40negative regulation of cell growthGO:00303089.5AGT, AGTR2, TGFB1
41positive regulation of protein kinase B signalingGO:00518979.4IL6, TGFB1, TNF
42negative regulation of fat cell differentiationGO:00455999.4IL6, TGFB1, TNF
43cellular response to dexamethasone stimulusGO:00715499.2AGTR2, IL6, TGFB1
44positive regulation of peptidyl-serine phosphorylationGO:00331389.1IL6, TGFB1, TNF
45inflammatory responseGO:00069548.9AGTR2, IL6, TGFB1, TNF
46positive regulation of NF-kappaB transcription factor activityGO:00510928.9AGT, IL6, TGFB1, TNF
47regulation of vasoconstrictionGO:00192298.7ACE, ACE2, AGT, AGTR1
48positive regulation of nitric oxide biosynthetic processGO:00454298.7AGT, AGTR2, IL6, TNF
49positive regulation of transcription, DNA-templatedGO:00458938.2AGT, AGTR2, IL6, TGFB1, TNF
50regulation of cell proliferationGO:00421277.8ACE2, AGT, AGTR1, IL6, TGFB1, TNF

Molecular functions related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.5ACE, AGTR1
2angiotensin type II receptor activityGO:000494510.3AGTR1, AGTR2
3peptidyl-dipeptidase activityGO:000824110.3ACE, ACE2
4carboxypeptidase activityGO:000418010.0ACE, ACE2
5growth factor activityGO:00080839.3AGT, IL6, TGFB1
6cytokine activityGO:00051259.2IL6, TGFB1, TNF
7protein heterodimerization activityGO:00469828.6AGTR1, SLC3A1, TBX18, TGFB1

Sources for Posterior Urethral Valves

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet