MCID: PST041
MIFTS: 31

Posterior Urethral Valves malady

Summaries for Posterior Urethral Valves

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32MalaCards
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MalaCards: Posterior Urethral Valves is related to vesicoureteral reflux and urinary tract obstruction. An important gene associated with Posterior Urethral Valves is AGTR1 (angiotensin II receptor, type 1), and among its related pathways are Thromboxane signalling through TP receptor and A-beta Uptake & Degradation. The compounds norepinephrine and temocaprilat have been mentioned in the context of this disorder. Related mouse phenotypes are adipose tissue and muscle.

Aliases & Classifications for Posterior Urethral Valves

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

posterior urethral valves 42 60


Related Diseases for Posterior Urethral Valves

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Clinical Features for Posterior Urethral Valves

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Drugs & Therapeutics for Posterior Urethral Valves

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Posterior Urethral Valves

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Anatomical Context for Posterior Urethral Valves

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Animal Models for Posterior Urethral Valves or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Posterior Urethral Valves:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.1AGTR2, AGT, ACE, TGFB1
2MP:00053697.8AGTR2, AGT, ACE2, TGFB1
3MP:00053787.6TGFB1, ACE, AGT, AGTR1, AGTR2
4MP:00053677.3TGFB1, ACE2, ACE, AGT, AGTR1, AGTR2
5MP:00053857.2AGTR2, AGTR1, AGT, ACE, ACE2, TGFB1
6MP:00053767.2AGTR2, AGTR1, AGT, ACE, ACE2, TGFB1
7MP:00107687.0AGTR2, AGTR1, AGT, ACE, ACE2, TGFB1

Publications for Posterior Urethral Valves

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Genetic Variations for Posterior Urethral Valves

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Expression for genes affiliated with Posterior Urethral Valves

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Posterior Urethral Valves

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Pathways for genes affiliated with Posterior Urethral Valves

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53Reactome, 12EMD Millipore, 52R&D Systems, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Posterior Urethral Valves

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Posterior Urethral Valves according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2411.9AGTR2
2temocaprilat449.9AGTR1, ACE
3cv 11974449.8AGTR1, AGT
4remikiren44 1110.8ACE, AGT
5benazepril hydrochloride599.7ACE, ACE2
6moexipril hydrochloride599.7ACE, ACE2
7perindopril erbumine599.7ACE, ACE2
8superoxide44 2410.7AGT, AGTR1
9lacidipine449.7AGTR1, ACE
10moexipril44 1110.6ACE, ACE2
11captopril44 28 49 59 1113.6AGTR2, ACE2
12etoperidone449.6AGTR1, AGTR2
13angiotensin i289.6AGTR1, AGTR2
14angiotensin iii289.6AGTR1, AGTR2
15cilazapril44 1110.5ACE, AGTR1
16aliskiren44 1110.5ACE, AGT, AGTR1
17eprosartan44 28 1111.5AGTR1, AGT, ACE
18olmesartan44 28 1111.5ACE, AGT, AGTR1
19Tasosartan119.5AGTR1, AGTR2
20chymostatin449.5ACE, AGT, AGTR1
21atenolol44 28 49 11 2413.5ACE, AGT, AGTR1
22hydrochlorothiazide44 49 28 11 2413.5ACE, AGT, AGTR1
23diltiazem44 28 1111.4AGTR1, AGT, ACE
24amlodipine44 49 11 2412.4AGTR1, AGT, ACE
25eplerenone44 59 28 1112.4ACE2, ACE, AGTR1
26enalaprilat449.4AGT, ACE, ACE2
27nadph44 2410.3ACE2, AGTR2
28trandolapril44 1110.2ACE, AGTR1
29cgp42112a449.2AGT, AGTR1, AGTR2
30spironolactone49 44 59 28 1113.1AGTR2, AGTR1, ACE
31lisinopril44 11 2411.0ACE2, ACE, AGT, AGTR1
32benazepril44 119.9AGTR1, AGT, ACE, TGFB1
33perindopril44 49 1110.9AGTR1, AGT, ACE, TGFB1
34nifedipine44 49 28 1111.8AGTR1, AGT, ACE, TGFB1
35ramipril44 119.8AGTR1, ACE, ACE2, TGFB1
36verapamil44 49 28 11 2412.8TGFB1, ACE, AGTR1
37saralasin448.7AGTR2, AGTR1, AGT, ACE
38pd12331944 289.7AGTR2, AGTR1, AGT, ACE
39valsartan44 59 28 1111.7AGTR2, AGTR1, AGT, ACE
40telmisartan44 28 1110.7AGTR2, AGTR1, AGT, ACE
41irbesartan44 28 49 1111.7AGTR2, AGTR1, AGT, ACE
42enalapril44 49 1110.7AGTR2, AGTR1, AGT, ACE
43angiotensin ii28 249.6AGTR2, AGTR1, ACE, ACE2
44prostacyclin448.6AGTR2, AGTR1, AGT, ACE
45sodium44 249.3AGTR2, AGTR1, AGT, ACE
46candesartan44 28 1110.1TGFB1, ACE, AGT, AGTR1, AGTR2
47ang ii448.1AGTR2, AGTR1, AGT, ACE, TGFB1
48losartan44 49 28 1111.1AGTR2, AGTR1, AGT, ACE, TGFB1
49creatinine448.0AGTR2, AGTR1, AGT, ACE, TGFB1
50nitric oxide44 11 2410.0AGTR2, AGTR1, AGT, ACE, ACE2

GO Terms for genes affiliated with Posterior Urethral Valves

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16Gene Ontology
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Cellular components related to Posterior Urethral Valves according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4TGFB1, ACE2, ACE, AGT
2extracellular regionGO:0055767.2TGFB1, ACE2, ACE, AGT, AGTR2

Biological processes related to Posterior Urethral Valves according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.0AGTR1, AGT
2regulation of blood vessel size by renin-angiotensinGO:00203410.0AGTR1, AGT
3regulation of renal sodium excretionGO:03581310.0AGTR1, AGT
4positive regulation of cholesterol esterificationGO:0108739.9AGT, AGTR1
5regulation of renal output by angiotensinGO:0020199.9AGT, ACE
6low-density lipoprotein particle remodelingGO:0343749.9AGT, AGTR1
7angiotensin-mediated drinking behaviorGO:0030519.9AGT, ACE2
8positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGT, AGTR1
9angiotensin catabolic process in bloodGO:0020059.8ACE, ACE2
10mononuclear cell proliferationGO:0329439.7ACE, TGFB1
11positive regulation of superoxide anion generationGO:0329309.7TGFB1, AGT
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.7AGTR1, AGT
13regulation of inflammatory responseGO:0507279.7AGTR1, ACE2
14positive regulation of inflammatory responseGO:0507299.6AGT, AGTR1
15cell growth involved in cardiac muscle cell developmentGO:0610499.6AGTR2, AGT
16negative regulation of neurotrophin TRK receptor signaling pathwayGO:0513879.6AGTR2, AGT
17cellular sodium ion homeostasisGO:0068839.5AGTR2, AGT
18G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:0071999.5AGT, AGTR2
19positive regulation of reactive oxygen species metabolic processGO:20003799.5AGTR1, AGT, ACE2
20regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.4ACE2, ACE, AGTR1
21positive regulation of renal sodium excretionGO:0358159.4AGT, AGTR2
22regulation of vasodilationGO:0423129.4AGTR1, ACE, ACE2
23kidney developmentGO:0018229.4AGTR1, AGT, ACE
24nitric oxide mediated signal transductionGO:0072639.4AGT, AGTR2
25regulation of cell proliferationGO:0421279.4AGTR1, AGT, ACE2
26positive regulation of cellular protein metabolic processGO:0322709.4AGTR1, AGT, TGFB1
27angiotensin maturationGO:0020039.4AGT, ACE, ACE2
28positive regulation of extrinsic apoptotic signaling pathwayGO:20012389.4AGTR2, AGT
29cellular response to dexamethasone stimulusGO:0715499.3TGFB1, AGTR2
30regulation of cell growthGO:0015589.3AGT, AGTR1
31negative regulation of blood vessel endothelial cell migrationGO:0435379.3AGTR2, TGFB1
32renin-angiotensin regulation of aldosterone productionGO:0020189.2AGTR2, AGTR1, AGT
33blood vessel remodelingGO:0019749.1ACE, AGT, AGTR2
34regulation of blood pressureGO:0082179.0AGTR2, ACE
35regulation of vasoconstrictionGO:0192299.0ACE2, ACE, AGT, AGTR1
36positive regulation of branching involved in ureteric bud morphogenesisGO:0901909.0TGFB1, AGT, AGTR2
37G-protein coupled receptor signaling pathwayGO:0071868.9AGT, AGTR1, AGTR2
38negative regulation of cell growthGO:0303088.9AGTR2, AGT, TGFB1
39positive regulation of transcription, DNA-dependentGO:0458938.6TGFB1, AGT, AGTR2

Molecular functions related to Posterior Urethral Valves according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:0106989.8AGT, AGTR1
2bradykinin receptor bindingGO:0317119.7ACE, AGTR1
3peptidyl-dipeptidase activityGO:0082419.5ACE2, ACE
4carboxypeptidase activityGO:0041809.4ACE, ACE2
5metallopeptidase activityGO:0082379.4ACE2, ACE
6angiotensin type II receptor activityGO:0049459.3AGTR1, AGTR2
7endopeptidase activityGO:0041759.1ACE2, ACE
8peptide hormone bindingGO:0170469.0ACE2, AGTR2

Products for genes affiliated with Posterior Urethral Valves

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  • Antibodies
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Sources for Posterior Urethral Valves

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet