MCID: PST041
MIFTS: 43

Posterior Urethral Valves malady

Rare diseases, Nephrological diseases, Fetal diseases categories

Aliases & Classifications for Posterior Urethral Valves

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Sources:
45NIH Rare Diseases, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Posterior Urethral Valves:

Name: Posterior Urethral Valves 45
Congenital Posterior Urethral Valves 65
 
Posterior Urethral Valve 51
Puv 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
posterior urethral valve:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Antenatal,Neonatal; Age of death: early childhood


External Ids:

Orphanet51 93110
ICD10 via Orphanet28 Q64.2
UMLS via Orphanet66 C0238506, C0542520
ICD1027 Q64.2

Summaries for Posterior Urethral Valves

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Wikipedia:68 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards based summary: Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to perinephritis and tuberculosis. An important gene associated with Posterior Urethral Valves is DSTYK (Dual Serine/Threonine And Tyrosine Protein Kinase), and among its related pathways are Syndecan-1-mediated signaling events and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include lung, kidney and prostate, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Related Diseases for Posterior Urethral Valves

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Diseases in the Anterior Urethral Valve family:

posterior urethral valves

Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1perinephritis30.4ACE, AGT, AGTR1
2tuberculosis30.4IL6, TGFB1, TNF
3posterior valve urethra28.3ACE, ACE2, AGT, AGTR1, AGTR2, DSTYK
4urethritis11.6
5vesicoureteral reflux10.8
6prune belly syndrome10.7
7down syndrome10.6
8urethral stricture10.5
9renal dysplasia10.5
10orchitis10.4
11ureterocele10.4
12epididymo-orchitis10.4
13urinary tract obstruction10.4
14anterior urethral valve10.4
15congenital anomalies of kidney and urinary tract10.4
16floating-harbor syndrome10.4
17cryptorchidism10.4
18renal tubular acidosis10.4
19bladder neck obstruction10.4
20urethral diverticulum10.4
21imperforate anus10.4
22hypospadias10.4
23kidney disease10.4
24prostatitis10.4
25pediatric multiple sclerosis10.3ACE, AGT
26penis squamous cell carcinoma10.2ACE, TGFB1
27congenital chloride diarrhea10.2ACE, IL6
28familial hyperthyroidism due to mutations in tsh receptor10.2AGT, AGTR1
29epidermolysis bullosa, junctional, non-herlitz type10.2
30alstrom syndrome10.2
31beckwith-wiedemann syndrome10.2
32hypersensitivity syndrome, carbamazepine-induced10.2
33silver-russell syndrome10.2
34williams-beuren syndrome10.2
35urofacial syndrome 110.2
36gastroesophageal reflux10.2
37familial mediterranean fever, ar10.2
38townes-brocks syndrome10.2
39meckel syndrome 110.2
40kindler syndrome10.2
41mckusick-kaufman syndrome10.2
42frontometaphyseal dysplasia10.2
43pelviureteric junction obstruction10.2
44hand-foot-uterus syndrome10.2
45arthritis10.2
46end stage renal failure10.2
47hepatitis10.2
48hepatitis b10.2
49pseudohypoaldosteronism10.2
50sinusitis10.2

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Symptoms for Posterior Urethral Valves

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Drugs & Therapeutics for Posterior Urethral Valves

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Drugs for Posterior Urethral Valves (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Fentanylapproved, illicit, investigationalPhase 2649437-38-73345
Synonyms:
1-Phenethyl-4-(N-phenylpropionamido)piperidine
1-Phenethyl-4-N-propionylanilinopiperidine
437-38-7
5-22-08-00049 (Beilstein Handbook Reference)
80832-90-2
990-73-8 (citrate)
AC1L1FQ2
Abstral
Actiq
BIDD:GT0555
BRN 0494484
CHEBI:119915
CHEMBL596
CID3345
D00320
DB00813
Duragesic
Duragesic (TN)
Duragesic-100
Duragesic-12
Duragesic-25
Duragesic-50
Duragesic-75
Durogesic
EINECS 207-113-6
Fentanest
Fentanil
Fentanil [DCIT]
Fentanila
Fentanila [INN-Spanish]
Fentanilo
Fentanyl
Fentanyl (JAN/USAN/INN)
Fentanyl - Novaplus
Fentanyl Citrate
Fentanyl [INN:BAN]
Fentanyl citrate
Fentanyl-100
 
Fentanyl-12
Fentanyl-25
Fentanyl-50
Fentanyl-75
Fentanylum
Fentanylum [INN-Latin]
HSDB 3329
IONSYS
JNS020QD
L001275
LS-124439
Lazanda
Matrifen
MolPort-003-847-369
N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-Phenethyl-4-piperidyl)propionanilide
N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide
N-Phenethyl-4-(N-propionylanilino)piperidine
N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
NCGC00168252-01
Nasalfent
Oprea1_152073
Oprea1_207148
PDSP1_000860
PDSP2_000846
Pentanyl
Phentanyl
Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)
R 4263
Rapinyl
Sentonil
Sublimase
Sublimaze
Subsys
UNII-UF599785JZ
fentanyl

Interventional clinical trials:

idNameStatusNCT IDPhase
1Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract ObstructionsNot yet recruitingNCT01552824Phase 2
2Fetal Cystoscopy for Lower Urinary Tract ObstructionRecruitingNCT02446184Phase 1
3CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral ValvesRecruitingNCT01537601
4Standardized Prenatal Clinical Care for LUTORecruitingNCT02315521

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

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Anatomical Context for Posterior Urethral Valves

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MalaCards organs/tissues related to Posterior Urethral Valves:

33
Lung, Kidney, Prostate, Testes, Spinal cord

Animal Models for Posterior Urethral Valves or affiliated genes

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MGI Mouse Phenotypes related to Posterior Urethral Valves:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8ACE, AGT, IL6, TGFB1, TNF
2MP:00020068.2ACE, AGTR2, IL6, TGFB1, TNF
3MP:00053697.9ACE2, AGT, AGTR2, IL6, TGFB1, TNF
4MP:00053757.4ACE, AGT, AGTR2, IL6, SLC3A1, TGFB1
5MP:00053877.2ACE, AGT, AGTR1, IL6, SLC3A1, TGFB1
6MP:00053857.1ACE, ACE2, AGT, AGTR1, AGTR2, IL6
7MP:00107687.0ACE, ACE2, AGT, AGTR1, AGTR2, IL6
8MP:00053676.8ACE, ACE2, AGT, AGTR1, AGTR2, IL6
9MP:00053786.7ACE, AGT, AGTR1, AGTR2, IL6, SLC3A1
10MP:00053765.8ACE, ACE2, AGT, AGTR1, AGTR2, IL6

Publications for Posterior Urethral Valves

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Articles related to Posterior Urethral Valves:

(show top 50)    (show all 528)
idTitleAuthorsYear
1
Neonatal presentation of posterior urethral valves and tethered spinal cord. (25073498)
2014
2
Urinary tract tuberculosis in a child with late presentation posterior urethral valves. (24529021)
2014
3
Renal Parenchymal Area and Risk of ESRD in Boys with Posterior Urethral Valves. (24311709)
2013
4
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
5
Posterior urethral valves: Persistent renin angiotensin system activation after valve ablation and role of pre-emptive therapy with angiotensin converting enzyme-inhibitors on renal recovery. (23798811)
2013
6
Posterior Urethral Valves; A single Center Experience. (24800012)
2013
7
Utilization of computer enhanced visual learning (CEVL) method improves endoscopic diagnosis of posterior urethral valves (PUV). (22981142)
2013
8
Risk factors associated with chronic kidney disease in patients with posterior urethral valves without prenatal hydronephrosis. (21527193)
2011
9
A rare cause of ascites in a newborn: posterior urethral valve. (20158664)
2010
10
Etiopathogenesis and management of bladder dysfunction in patients with posterior urethral valves. (21369376)
2010
11
A follow-up study of children with posterior urethral valve. (20835319)
2010
12
Prognostic value of serum creatinine levels in children with posterior urethral valves treated by primary valve ablation. (19581129)
2010
13
Posterior urethral valves: a single center experience over 7 years. (19184051)
2009
14
Abnormal antenatal sonogram: an indicator of disease severity in children with posterior urethral valves. (19632082)
2009
15
Posterior urethral valves are often associated with cryptorchidism and inguinal hernias. (18554641)
2008
16
Concordant posterior urethral valves in male monochorionic twins with secondary prune belly syndrome. (19213520)
2008
17
Re: The effects of bladder neck incision on urodynamic abnormalities of children with posterior urethral valves. A. M. Kajbafzadeh, S. Payabvash and G. Karimian. J Urol 2007; 178: 2142-2149. (18436260)
2008
18
Posterior urethral valves in three siblings: a case report and review of the literature. (18240166)
2008
19
Renal transplantation in children with posterior urethral valves. (16491414)
2006
20
The impact of late presentation of posterior urethral valves on bladder and renal function. (16600793)
2006
21
Long-term followup of bilateral high (sober) urinary diversion in patients with posterior urethral valves and its effect on bladder function. (15821568)
2005
22
Myogenic bladder decompensation in boys with a history of posterior urethral valves is caused by secondary bladder neck obstruction? (15963137)
2005
23
Initial and long-term management of posterior urethral valves. (15558286)
2004
24
Long-term outcome of posterior urethral valves ablation using the Mohan's urethral valvotome. (15171523)
2004
25
Posterior urethral valves: prognostic factors. (12699486)
2003
26
Incidental adult posterior urethral valve without clinical features. (15072500)
2003
27
Posterior urethral valves and mirror image anomalies in monozygotic twins. (12210353)
2002
28
Xanthogranulomatous pyelonephritis in a dysplastic kidney with reflux associated with posterior urethral valves. (11832763)
2002
29
Prospective analysis of renal function and somatic growth in neonatal posterior urethral valves. (12369006)
2002
30
Posterior urethral valves. (12696266)
2002
31
Posterior urethral valves. (11294257)
2001
32
Increased urinary transforming growth factor-beta(1) excretion in children with posterior urethral valves. (10925100)
2000
33
The long-term complications of posterior urethral valves. (10330919)
1999
34
Applications of the KTP laser in the treatment of posterior urethral valves, ureteroceles, and urethral strictures in the pediatric patient. (9728129)
1998
35
The management of unilateral poorly functioning kidneys in patients with posterior urethral valves. (9258129)
1997
36
The long-term outcome of posterior urethral valves treated with primary valve ablation and observation. (8627873)
1996
37
Long-term bladder dysfunction in boys with posterior urethral valves. (8877354)
1996
38
Mercapto-acetyltriglycine (MAG 3) renography and indirect radionuclide cystography in posterior urethral valves. (7827852)
1994
39
Re: Delayed presentation of posterior urethral valves. S. A. Merchant et al. Br. J. Urol., 69, 318-319, 1992. (10071574)
1993
40
Unusual presentation of adult posterior urethral valve. (1422693)
1992
41
Re: Renal transplantation in children with posterior urethral valves. (1294129)
1992
42
Influence of initial therapy on progression of renal failure and body growth in children with posterior urethral valves. (1640516)
1992
43
99mTc DTPA scintigraphy compared with intravenous urography in the follow-up of posterior urethral valves. (3322473)
1987
44
Posterior urethral valves in Saudi Arabia. (3833844)
1985
45
Posterior urethral valves in the British Isles: a multicenter B.A.P.S. review. (6834230)
1983
46
Observations on persistently dilated ureter after posterior urethral valve ablation. (7112792)
1982
47
Major and minor complications of posterior urethral valves. (7288943)
1981
48
The protean aspects of posterior urethral valves. (7321118)
1981
49
Nursing care study - posterior urethral valves. A sick baby makes a fresh start. (6898045)
1980
50
3 case reports of posterior urethral valves with varied presentations. (1021125)
1976

Variations for Posterior Urethral Valves

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Expression for genes affiliated with Posterior Urethral Valves

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Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for genes affiliated with Posterior Urethral Valves

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Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL6, TGFB1
29.7IL6, TGFB1
39.6TGFB1, TNF
49.6ACE, ACE2
59.5IL6, TNF
69.3ACE, AGT, AGTR1
79.3AGT, TGFB1, TNF
8
Show member pathways
9.2ACE, ACE2, AGT
99.2IL6, TGFB1, TNF
109.2IL6, TGFB1, TNF
119.2IL6, TGFB1, TNF
129.2IL6, TGFB1, TNF
13
Show member pathways
9.2IL6, TGFB1, TNF
149.2IL6, TGFB1, TNF
159.2IL6, TGFB1, TNF
169.2IL6, TGFB1, TNF
17
Show member pathways
8.9ACE, IL6, TGFB1, TNF
18
Show member pathways
8.9ACE, IL6, TGFB1, TNF
198.9AGT, IL6, TGFB1, TNF
20
Show member pathways
8.7AGT, AGTR2, IL6, TGFB1
21
Show member pathways
7.9ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
22
Show member pathways
7.8ACE, ACE2, AGT, AGTR1, AGTR2, TGFB1
23
Show member pathways
7.8AGT, AGTR1, AGTR2, IL6, TGFB1, TNF

GO Terms for genes affiliated with Posterior Urethral Valves

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Cellular components related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.0ACE, ACE2, AGT, IL6, TGFB1, TNF
2extracellular regionGO:00055767.1ACE, ACE2, AGT, AGTR2, IL6, TGFB1

Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:003294310.5ACE, TGFB1
2regulation of renal output by angiotensinGO:000201910.5ACE, AGT
3neutrophil mediated immunityGO:000244610.4ACE, IL6
4positive regulation of NAD(P)H oxidase activityGO:003386410.4AGT, AGTR1
5regulation of blood vessel size by renin-angiotensinGO:000203410.4AGT, AGTR1
6angiotensin catabolic process in bloodGO:000200510.4ACE, ACE2
7angiotensin-mediated drinking behaviorGO:000305110.3ACE2, AGT
8positive regulation of gap junction assemblyGO:190359810.3ACE2, AGT
9positive regulation of cholesterol esterificationGO:001087310.3AGT, AGTR1
10low-density lipoprotein particle remodelingGO:003437410.3AGT, AGTR1
11regulation of renal sodium excretionGO:003581310.2AGT, AGTR1
12epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.2IL6, TNF
13negative regulation of lipid storageGO:001088810.2IL6, TNF
14regulation of cardiac conductionGO:190377910.2ACE2, AGT
15negative regulation of blood vessel endothelial cell migrationGO:004353710.2AGTR2, TGFB1
16positive regulation of superoxide anion generationGO:003293010.1AGT, TGFB1
17regulation of systemic arterial blood pressure by circulatory renin-angiotensinGO:000199110.1AGT, AGTR2
18brain renin-angiotensin systemGO:000203510.1AGT, AGTR2
19response to salt stressGO:000965110.1AGT, TNF
20G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:000719910.1AGT, AGTR2
21negative regulation of neurotrophin TRK receptor signaling pathwayGO:005138710.1AGT, AGTR2
22receptor biosynthetic processGO:003280010.1ACE2, TNF
23positive regulation of macrophage derived foam cell differentiationGO:001074410.1AGT, AGTR1
24angiotensin-activated signaling pathwayGO:003816610.0AGTR1, AGTR2
25cell growth involved in cardiac muscle cell developmentGO:006104910.0AGT, AGTR2
26regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.9ACE, ACE2, AGTR1
27negative regulation of fat cell differentiationGO:00455999.8IL6, TGFB1, TNF
28positive regulation of branching involved in ureteric bud morphogenesisGO:00901909.8AGT, AGTR2, TGFB1
29positive regulation of cellular protein metabolic processGO:00322709.8AGT, AGTR1, TGFB1
30positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.7AGT, IL6, TGFB1
31regulation of vasodilationGO:00423129.7ACE, ACE2, AGTR1
32positive regulation of protein kinase B signalingGO:00518979.7IL6, TGFB1, TNF
33renin-angiotensin regulation of aldosterone productionGO:00020189.7AGT, AGTR1, AGTR2
34angiotensin maturationGO:00020039.7ACE, ACE2, AGT
35positive regulation of renal sodium excretionGO:00358159.6AGT, AGTR2
36regulation of blood pressureGO:00082179.5ACE, AGT, AGTR2
37blood vessel remodelingGO:00019749.5ACE, AGT, AGTR2
38negative regulation of cell growthGO:00303089.4AGT, AGTR2, TGFB1
39regulation of vasoconstrictionGO:00192299.4ACE, ACE2, AGT, AGTR1
40positive regulation of peptidyl-serine phosphorylationGO:00331389.3AGT, IL6, TGFB1, TNF
41positive regulation of NF-kappaB transcription factor activityGO:00510929.3AGT, IL6, TGFB1, TNF
42regulation of inflammatory responseGO:00507279.1ACE2, AGT, AGTR1
43cellular response to dexamethasone stimulusGO:00715499.1AGTR2, IL6, TGFB1
44positive regulation of reactive oxygen species metabolic processGO:20003799.0ACE2, AGT, AGTR1
45inflammatory responseGO:00069548.9AGTR2, IL6, TGFB1, TNF
46kidney developmentGO:00018228.9ACE, AGT, AGTR1, AGTR2
47positive regulation of nitric oxide biosynthetic processGO:00454298.8AGT, AGTR2, IL6, TNF
48positive regulation of gene expressionGO:00106288.6AGT, IL6, TGFB1, TNF
49positive regulation of transcription, DNA-templatedGO:00458938.4AGT, AGTR2, IL6, TGFB1, TNF
50regulation of cell proliferationGO:00421277.9ACE2, AGT, AGTR1, IL6, TGFB1, TNF

Molecular functions related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.3ACE, AGTR1
2peptidyl-dipeptidase activityGO:000824110.0ACE, ACE2
3angiotensin type II receptor activityGO:00049459.9AGTR1, AGTR2
4carboxypeptidase activityGO:00041809.8ACE, ACE2
5growth factor activityGO:00080839.4AGT, IL6, TGFB1
6cytokine activityGO:00051259.2IL6, TGFB1, TNF

Sources for Posterior Urethral Valves

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet