MCID: PST041
MIFTS: 50

Posterior Urethral Valves malady

Rare diseases, Nephrological diseases, Fetal diseases categories

Aliases & Classifications for Posterior Urethral Valves

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Sources:
42NIH Rare Diseases, 48Orphanet, 61UMLS, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Posterior Urethral Valves:

Name: Posterior Urethral Valves 42
Congenital Posterior Urethral Valves 61
 
Posterior Urethral Valve 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
posterior urethral valve:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Antenatal,Neonatal; Age of death: early childhood


External Ids:

Orphanet48 93110
ICD10 via Orphanet26 Q64.2
UMLS via Orphanet62 C0238506, C0542520
ICD1025 Q64.2

Summaries for Posterior Urethral Valves

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Wikipedia:64 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards based summary: Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to vesicoureteral reflux and urinary tract obstruction. An important gene associated with Posterior Urethral Valves is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are A-beta Uptake and Degradation and A-beta Plaque Formation and APP Metabolism. The compounds cgp42112a and angiotensin iii have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and prostate, and related mouse phenotypes are tumorigenesis and respiratory system.

Related Diseases for Posterior Urethral Valves

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Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1vesicoureteral reflux31.4AGTR2, AGT, AGTR1
2urinary tract obstruction31.3ACE
3arthritis30.3TNF, IL6
4kidney disease29.7AGTR1, TNF, TGFB1, IL6, AGT
5urethritis11.6
6down syndrome10.6
7urethral stricture10.5
8renal dysplasia10.5
9orchitis10.4
10ureterocele10.4
11epididymo-orchitis10.4
12orthostatic intolerance10.4AGTR1
13malaria10.4TNF
14floating-harbor syndrome10.4
15kindler syndrome10.4
16cryptorchidism10.4
17eagle-barrett syndrome10.4
18renal tubular acidosis10.4
19hypospadias10.4
20urethral diverticulum10.4
21imperforate anus10.4
22bladder neck obstruction10.4
23prostatitis10.4
24epididymitis10.4
25crohn's disease10.3TNF
26renal tubular dysgenesis10.3AGTR1, AGT
27conn's syndrome10.3AGTR1, AGTR2
28renovascular hypertension10.2AGTR1, ACE
29hypertensive heart disease10.2ACE, AGTR1
30epidermolysis bullosa, junctional, non-herlitz type10.2
31congenital anomalies of kidney and urinary tract10.2
32alstrom syndrome10.2
33beckwith-wiedemann syndrome10.2
34silver-russell syndrome10.2
35williams-beuren syndrome10.2
36urofacial syndrome 110.2
37townes-brocks syndrome10.2
38mckusick-kaufman syndrome10.2
39frontometaphyseal dysplasia10.2
40vacterl association10.2
41hypersensitivity syndrome, carbamazepine-induced10.2
42hand-foot-uterus syndrome10.2
43pseudohermaphroditism, male, with gynecomastia10.2
44meckel syndrome 110.2
45end stage renal failure10.2
46hepatitis10.2
47hepatitis b10.2
48pseudohypoaldosteronism10.2
49sinusitis10.2
50dyskeratosis congenita10.2

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Symptoms for Posterior Urethral Valves

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Drugs & Therapeutics for Posterior Urethral Valves

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Drug clinical trials:

Search ClinicalTrials for Posterior Urethral Valves

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

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Anatomical Context for Posterior Urethral Valves

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MalaCards organs/tissues related to Posterior Urethral Valves:

31
Lung, Kidney, Prostate, Spinal cord, Testes

Animal Models for Posterior Urethral Valves or affiliated genes

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MGI Mouse Phenotypes related to Posterior Urethral Valves:

35 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9AGTR2, TNF, IL6, ACE, TGFB1
2MP:00053887.9IL6, TGFB1, TNF, ACE2
3MP:00053817.9IL6, TGFB1, TNF, AGTR2
4MP:00053707.9TGFB1, ACE, IL6, AGT, TNF
5MP:00036317.8TNF, TGFB1, AGTR2, AGT, IL6
6MP:00053797.7AGTR2, TGFB1, IL6, TNF, ACE
7MP:00053757.6TNF, TGFB1, AGT, ACE, IL6, AGTR2
8MP:00053677.5AGTR1, AGT, AGTR2, IL6, TGFB1, ACE2
9MP:00053697.5AGT, ACE2, TGFB1, TNF, IL6, AGTR2
10MP:00053867.5TGFB1, AGT, AGTR2, IL6, ACE, TNF
11MP:00053877.4TGFB1, IL6, ACE, AGTR1, AGT, TNF
12MP:00053847.3ACE2, IL6, AGTR2, TNF, ACE, TGFB1
13MP:00053787.1AGT, AGTR2, IL6, ACE, TGFB1, TNF
14MP:00053856.7ACE2, AGT, AGTR1, IL6, ACE, TGFB1
15MP:00053766.7AGTR1, AGT, IL6, ACE, ACE2, TGFB1
16MP:00107686.7TNF, AGTR1, TGFB1, ACE2, ACE, IL6

Publications for Posterior Urethral Valves

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Articles related to Posterior Urethral Valves:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
Neonatal presentation of posterior urethral valves and tethered spinal cord. (25073498)
2014
2
Urinary tract tuberculosis in a child with late presentation posterior urethral valves. (24529021)
2014
3
Renal Parenchymal Area and Risk of ESRD in Boys with Posterior Urethral Valves. (24311709)
2013
4
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
5
Posterior urethral valves: Persistent renin angiotensin system activation after valve ablation and role of pre-emptive therapy with angiotensin converting enzyme-inhibitors on renal recovery. (23798811)
2013
6
Posterior Urethral Valves; A single Center Experience. (24800012)
2013
7
Risk factors associated with chronic kidney disease in patients with posterior urethral valves without prenatal hydronephrosis. (21527193)
2011
8
A rare cause of ascites in a newborn: posterior urethral valve. (20158664)
2010
9
Etiopathogenesis and management of bladder dysfunction in patients with posterior urethral valves. (21369376)
2010
10
A follow-up study of children with posterior urethral valve. (20835319)
2010
11
Prognostic value of serum creatinine levels in children with posterior urethral valves treated by primary valve ablation. (19581129)
2010
12
Posterior urethral valves: a single center experience over 7 years. (19184051)
2009
13
Abnormal antenatal sonogram: an indicator of disease severity in children with posterior urethral valves. (19632082)
2009
14
Posterior urethral valves are often associated with cryptorchidism and inguinal hernias. (18554641)
2008
15
Concordant posterior urethral valves in male monochorionic twins with secondary prune belly syndrome. (19213520)
2008
16
Re: The effects of bladder neck incision on urodynamic abnormalities of children with posterior urethral valves. A. M. Kajbafzadeh, S. Payabvash and G. Karimian. J Urol 2007; 178: 2142-2149. (18436260)
2008
17
Posterior urethral valves in three siblings: a case report and review of the literature. (18240166)
2008
18
Renal transplantation in children with posterior urethral valves. (16491414)
2006
19
The impact of late presentation of posterior urethral valves on bladder and renal function. (16600793)
2006
20
Long-term followup of bilateral high (sober) urinary diversion in patients with posterior urethral valves and its effect on bladder function. (15821568)
2005
21
Myogenic bladder decompensation in boys with a history of posterior urethral valves is caused by secondary bladder neck obstruction? (15963137)
2005
22
Initial and long-term management of posterior urethral valves. (15558286)
2004
23
Long-term outcome of posterior urethral valves ablation using the Mohan's urethral valvotome. (15171523)
2004
24
Posterior urethral valves: prognostic factors. (12699486)
2003
25
Incidental adult posterior urethral valve without clinical features. (15072500)
2003
26
Posterior urethral valves and mirror image anomalies in monozygotic twins. (12210353)
2002
27
Xanthogranulomatous pyelonephritis in a dysplastic kidney with reflux associated with posterior urethral valves. (11832763)
2002
28
Prospective analysis of renal function and somatic growth in neonatal posterior urethral valves. (12369006)
2002
29
Posterior urethral valves. (12696266)
2002
30
Posterior urethral valves. (11294257)
2001
31
Increased urinary transforming growth factor-beta(1) excretion in children with posterior urethral valves. (10925100)
2000
32
The long-term complications of posterior urethral valves. (10330919)
1999
33
Applications of the KTP laser in the treatment of posterior urethral valves, ureteroceles, and urethral strictures in the pediatric patient. (9728129)
1998
34
The management of unilateral poorly functioning kidneys in patients with posterior urethral valves. (9258129)
1997
35
The long-term outcome of posterior urethral valves treated with primary valve ablation and observation. (8627873)
1996
36
Long-term bladder dysfunction in boys with posterior urethral valves. (8877354)
1996
37
Mercapto-acetyltriglycine (MAG 3) renography and indirect radionuclide cystography in posterior urethral valves. (7827852)
1994
38
Re: Delayed presentation of posterior urethral valves. S. A. Merchant et al. Br. J. Urol., 69, 318-319, 1992. (10071574)
1993
39
Unusual presentation of adult posterior urethral valve. (1422693)
1992
40
Re: Renal transplantation in children with posterior urethral valves. (1294129)
1992
41
Influence of initial therapy on progression of renal failure and body growth in children with posterior urethral valves. (1640516)
1992
42
99mTc DTPA scintigraphy compared with intravenous urography in the follow-up of posterior urethral valves. (3322473)
1987
43
Posterior urethral valves in Saudi Arabia. (3833844)
1985
44
Posterior urethral valves in the British Isles: a multicenter B.A.P.S. review. (6834230)
1983
45
Observations on persistently dilated ureter after posterior urethral valve ablation. (7112792)
1982
46
Major and minor complications of posterior urethral valves. (7288943)
1981
47
The protean aspects of posterior urethral valves. (7321118)
1981
48
Nursing care study - posterior urethral valves. A sick baby makes a fresh start. (6898045)
1980
49
Posterior urethral valves in siblings. (1268469)
1976
50
3 case reports of posterior urethral valves with varied presentations. (1021125)
1976

Variations for Posterior Urethral Valves

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Expression for genes affiliated with Posterior Urethral Valves

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Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for genes affiliated with Posterior Urethral Valves

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Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ACE2, ACE
29.5ACE2, ACE
39.3TGFB1, IL6
4
Show member pathways
9.3IL6, TGFB1
5
Show member pathways
9.3TGFB1, IL6
6
Show member pathways
Serotonin Transporter Activity36
9.3AGT, TNF
79.1TNF, TGFB1
89.1TNF, TGFB1
9
Show member pathways
9.1TNF, TGFB1
10
Show member pathways
9.1AGT, ACE2, ACE
119.0TNF, IL6
129.0IL6, TNF
139.0IL6, TNF
149.0TNF, IL6
159.0TNF, IL6
169.0IL6, TNF
179.0IL6, TNF
188.8TNF, AGT, TGFB1
19
Show member pathways
8.8AGT, TGFB1, TNF
20
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
8.6AGTR1, TNF, IL6
21
Show member pathways
8.6IL6, TGFB1, AGT, AGTR2
22
Show member pathways
8.5TNF, TGFB1, IL6
23
Show member pathways
8.5TGFB1, IL6, TNF
248.5IL6, TGFB1, TNF
258.5TGFB1, TNF, IL6
26
Show member pathways
8.5TNF, IL6, TGFB1
27
Show member pathways
IL27-mediated signaling events36
8.5TGFB1, TNF, IL6
288.5IL6, TNF, TGFB1
298.5TNF, IL6, TGFB1
308.5TNF, TGFB1, IL6
318.5TNF, TGFB1, IL6
32
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.5TNF, TGFB1, IL6
338.5IL6, TGFB1, TNF
34
Show member pathways
8.5IL6, TNF, TGFB1
358.5TNF, TGFB1, IL6
368.1AGT, TNF, IL6, TGFB1
37
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
8.1TNF, TGFB1, IL6, ACE
38
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.1ACE, TGFB1, TNF, IL6
39
Show member pathways
7.8AGTR1, AGTR2, ACE, AGT, ACE2, TGFB1
40
Show member pathways
7.7TGFB1, ACE, AGT, AGTR2, IL6, AGTR1
41
Show member pathways
7.4AGT, TNF, AGTR2, IL6, TGFB1, AGTR1

Compounds for genes affiliated with Posterior Urethral Valves

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Compounds related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show top 50)    (show all 159)
idCompoundScoreTop Affiliating Genes
1cgp42112a449.7AGTR2, AGTR1, AGT
2angiotensin iii289.7AGTR2, AGTR1
3aliskiren44 1110.6ACE, AGT, AGTR1
4etoperidone449.6AGTR2, AGTR1
5eprosartan44 28 1111.6ACE, AGTR1, AGT
6olmesartan44 28 1111.6AGTR1, ACE, AGT
7chymostatin449.6AGTR1, ACE, AGT
8atenolol44 50 28 24 1113.5ACE, AGTR1, AGT
9diltiazem44 28 50 1112.5AGT, AGTR1, ACE
10enalaprilat449.5AGT, ACE2, ACE
11hydrochlorothiazide44 28 50 24 1113.5AGTR1, ACE, AGT
12eplerenone44 60 28 1112.4ACE, AGTR1, ACE2
13spironolactone44 60 28 50 1113.4AGTR1, ACE, AGTR2
14amlodipine44 50 24 1112.4ACE, AGT, AGTR1
15angiotensin i289.4AGTR1, AGTR2
16saralasin449.3AGTR1, AGT, AGTR2, ACE
17pd12331944 2810.3AGTR2, AGTR1, ACE, AGT
18valsartan44 60 28 1112.3AGTR1, AGT, AGTR2, ACE
19telmisartan44 28 1111.3AGTR1, ACE, AGTR2, AGT
20irbesartan44 28 50 1112.3AGTR2, AGTR1, ACE, AGT
21enalapril44 50 1111.3AGTR1, AGT, ACE, AGTR2
22angiotensin ii28 2410.2AGTR1, AGTR2, ACE, ACE2
23benazepril44 50 1111.2AGTR1, TGFB1, AGT, ACE
24lisinopril44 50 24 1112.1AGTR1, AGT, ACE, ACE2
25perindopril44 50 1111.1ACE, TGFB1, AGTR1, AGT
26nifedipine44 28 50 1112.0ACE, AGT, AGTR1, TGFB1
27ramipril44 1110.0AGTR1, ACE2, TGFB1, ACE
28candesartan44 50 28 1111.8AGTR2, ACE, TGFB1, AGT, AGTR1
29ang ii448.8TGFB1, AGTR1, ACE, AGT, AGTR2
30captopril44 60 50 28 1112.8AGTR1, ACE2, ACE, AGTR2, AGT
31losartan44 50 28 1111.8TGFB1, ACE, AGT, AGTR1, AGTR2
328-isoprostane448.7AGTR1, IL6, TNF
33gm-csf44 289.7TNF, IL6, TGFB1
34norepinephrine44 24 1110.6AGT, AGTR1, ACE, AGTR2, IL6
35atorvastatin44 50 28 24 1112.5AGT, TNF, ACE, IL6
36simvastatin44 50 60 28 24 1113.5AGT, AGTR1, IL6, TNF
37prostacyclin448.5ACE, AGTR2, TNF, AGT, AGTR1
38rosiglitazone28 44 50 24 1112.4AGTR1, IL6, TGFB1, TNF
39tgf beta1448.4IL6, TNF, TGFB1, AGTR1
40superoxide44 249.3ACE2, AGTR1, TNF, AGT, AGTR2
41prostaglandin448.3TNF, AGTR2, AGT, IL6, AGTR1
42cholesterol44 28 24 1111.2ACE2, ACE, IL6, AGTR1, AGT
43indomethacin44 28 60 1111.2AGTR2, IL6, TGFB1, TNF, AGT
44creatinine448.2AGTR1, AGTR2, AGT, ACE, TGFB1, IL6
45sb 20358044 609.1IL6, TNF, TGFB1, AGT, AGTR1
46actinomycin d448.1TNF, TGFB1, IL6, AGT, AGTR1
47cycloheximide448.0AGTR1, AGTR2, IL6, TGFB1, TNF
48cyclosporin a44 28 609.8TGFB1, AGTR1, AGT, TNF, IL6, AGTR2
49dexamethasone44 50 28 1110.7IL6, AGT, TGFB1, TNF, AGTR1
50nitric oxide44 24 119.3TNF, IL6, AGTR2, AGTR1, AGT, ACE

GO Terms for genes affiliated with Posterior Urethral Valves

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Cellular components related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.6ACE2, TGFB1, TNF
2external side of plasma membraneGO:00098978.5IL6, ACE, TNF
3extracellular spaceGO:00056157.2TNF, TGFB1, ACE2, ACE, IL6, AGT
4plasma membraneGO:00058867.1TNF, TGFB1, ACE2, ACE, AGTR2, AGTR1
5extracellular regionGO:00055766.9AGT, TNF, TGFB1, ACE2, ACE, IL6

Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idNameGO IDScoreTop Affiliating Genes
1cell growth involved in cardiac muscle cell developmentGO:006104910.2AGT, AGTR2
2negative regulation of neurotrophin TRK receptor signaling pathwayGO:005138710.1AGTR2, AGT
3cellular sodium ion homeostasisGO:000688310.1AGT, AGTR2
4angiotensin-activated signaling pathwayGO:003816610.1AGTR1, AGTR2
5regulation of blood vessel size by renin-angiotensinGO:000203410.1AGT, AGTR1
6positive regulation of NAD(P)H oxidase activityGO:003386410.1AGTR1, AGT
7regulation of renal sodium excretionGO:003581310.1AGTR1, AGT
8regulation of renal output by angiotensinGO:000201910.1AGT, ACE
9G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:000719910.0AGT, AGTR2
10positive regulation of cholesterol esterificationGO:001087310.0AGTR1, AGT
11angiotensin-mediated drinking behaviorGO:000305110.0AGT, ACE2
12low-density lipoprotein particle remodelingGO:00343749.9AGT, AGTR1
13positive regulation of superoxide anion generationGO:00329309.9AGT, TGFB1
14mononuclear cell proliferationGO:00329439.9TGFB1, ACE
15positive regulation of renal sodium excretionGO:00358159.9AGTR2, AGT
16angiotensin catabolic process in bloodGO:00020059.9ACE, ACE2
17cellular response to dexamethasone stimulusGO:00715499.9AGTR2, TGFB1
18negative regulation of blood vessel endothelial cell migrationGO:00435379.8TGFB1, AGTR2
19positive regulation of macrophage derived foam cell differentiationGO:00107449.8AGTR1, AGT
20renin-angiotensin regulation of aldosterone productionGO:00020189.8AGTR2, AGT, AGTR1
21nitric oxide mediated signal transductionGO:00072639.8AGTR2, AGT
22blood vessel remodelingGO:00019749.7ACE, AGTR2, AGT
23positive regulation of branching involved in ureteric bud morphogenesisGO:00901909.7AGT, AGTR2, TGFB1
24positive regulation of cellular protein metabolic processGO:00322709.6AGT, AGTR1, TGFB1
25positive regulation of reactive oxygen species metabolic processGO:020003799.6ACE2, AGT, AGTR1
26kidney developmentGO:00018229.6ACE, AGT, AGTR1
27angiotensin maturationGO:00020039.6ACE2, ACE, AGT
28receptor biosynthetic processGO:00328009.5TNF, ACE2
29regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.5ACE, AGTR1, ACE2
30regulation of vasodilationGO:00423129.5ACE2, ACE, AGTR1
31negative regulation of cell growthGO:00303089.5TGFB1, AGTR2, AGT
32regulation of cell proliferationGO:00421279.5AGTR1, ACE2, AGT
33response to salt stressGO:00096519.5AGT, TNF
34negative regulation of lipid storageGO:00108889.4TNF, IL6
35epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.3IL6, TNF
36positive regulation of protein complex assemblyGO:00313349.3TNF, TGFB1
37positive regulation of cytokine secretionGO:00507159.3TNF, AGTR2
38agingGO:00075689.2IL6, AGT, TGFB1
39positive regulation of cytokine productionGO:00018199.2TNF, AGT
40regulation of vasoconstrictionGO:00192299.2ACE2, AGTR1, AGT, ACE
41positive regulation of nitric oxide biosynthetic processGO:00454299.1AGTR2, IL6, TNF
42positive regulation of chemokine productionGO:00327229.1IL6, TNF
43negative regulation of fat cell differentiationGO:00455998.9IL6, TGFB1, TNF
44positive regulation of peptidyl-serine phosphorylationGO:00331388.9IL6, TGFB1, TNF
45positive regulation of protein kinase B signalingGO:00518978.9IL6, TGFB1, TNF
46protein import into nucleus, translocationGO:00000608.8TGFB1, TNF
47positive regulation of NF-kappaB transcription factor activityGO:00510928.6TGFB1, TNF, AGT, IL6
48inflammatory responseGO:00069548.5IL6, TNF, AGTR2, TGFB1
49negative regulation of cell proliferationGO:00082858.5AGT, IL6, TGFB1, TNF
50positive regulation of transcription, DNA-templatedGO:00458938.2TGFB1, AGT, AGTR2, IL6, TNF

Molecular functions related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:00049459.9AGTR1, AGTR2
2bradykinin receptor bindingGO:00317119.8AGTR1, ACE
3peptidyl-dipeptidase activityGO:00082419.7ACE, ACE2
4carboxypeptidase activityGO:00041809.6ACE, ACE2
5peptide hormone bindingGO:00170469.5AGTR2, ACE2
6metallopeptidase activityGO:00082379.5ACE, ACE2
7endopeptidase activityGO:00041759.2ACE, ACE2
8growth factor activityGO:00080839.1TGFB1, IL6, AGT
9protein bindingGO:00055156.9TNF, TGFB1, ACE, IL6, AGTR2, AGT

Sources for Posterior Urethral Valves

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet