MCID: PST041
MIFTS: 51

Posterior Urethral Valves malady

Categories: Rare diseases, Nephrological diseases, Fetal diseases

Aliases & Classifications for Posterior Urethral Valves

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Sources:
45NIH Rare Diseases, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Posterior Urethral Valves:

Name: Posterior Urethral Valves 45
Congenital Posterior Urethral Valves 65
 
Posterior Urethral Valve 51
Puv 51

Characteristics:

Orphanet epidemiological data:

51
posterior urethral valve:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Antenatal,Neonatal; Age of death: early childhood

Classifications:



External Ids:

Orphanet51 93110
ICD10 via Orphanet28 Q64.2
UMLS via Orphanet66 C0238506, C0542520
ICD1027 Q64.2
UMLS65 C0238506

Summaries for Posterior Urethral Valves

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Wikipedia:68 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards based summary: Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to congenital anomalies of kidney and urinary tract and neurogenic bladder. An important gene associated with Posterior Urethral Valves is TBX18 (T-Box 18), and among its related pathways are A-beta Pathways: Plaque Formation and APP Metabolism and A-beta Pathways: Uptake and Degradation. Affiliated tissues include lung, kidney and heart, and related mouse phenotypes are tumorigenesis and respiratory system.

Related Diseases for Posterior Urethral Valves

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Diseases in the Anterior Urethral Valve family:

posterior urethral valves

Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1congenital anomalies of kidney and urinary tract31.5DSTYK, TBX18
2neurogenic bladder29.3IL6, TGFB1, TNF
3urethritis11.2
4glandular cystitis10.5ACE, AGTR1
5coxa vara, congenital10.5ACE, AGTR1
6pustulosis of palm and sole10.5ACE, TNF
7cerebral sarcoidosis10.4ACE, TNF
8vesicoureteral reflux10.4
9best1 retinopathy10.4TGFB1, TNF
10opisthorchiasis10.4TGFB1, TNF
11endogenous depression10.4ACE, AGTR1
12pediatric multiple sclerosis10.4ACE, AGT
13prune belly syndrome10.3
14chromosome 9p deletion syndrome10.3ACE, TNF
15heart aneurysm10.3AGTR1, AGTR2
16cerebral lipidosis10.3ACE, AGTR1
17goat milk allergy10.3TGFB1, TNF
18congenital nasal pyriform aperture stenosis with holoprosencephaly10.3ACE, TNF
19down syndrome10.3
20parametritis10.2ACE, AGT
21patau syndrome10.2ACE, AGTR1, TGFB1
22meningococcemia10.2AGT, AGTR1
23antiphospholipid syndrome10.2ACE, AGTR1, TGFB1
24primary non-gestational choriocarcinoma of ovary10.2ACE, AGTR2, TGFB1
25pelviureteric junction obstruction10.2
26urethral stricture10.2
27renal dysplasia10.2
28specific bursitis often of occupational origin10.1ACE, AGT
29single ventricular heart10.1ACE, TGFB1, TNF
30imperforate anus10.1
31orchitis10.1
32ureterocele10.1
33urinary tract obstruction10.1
34kidney disease10.1
35epididymo-orchitis10.1
36anterior urethral valve10.1
37thyroiditis10.1IL6, TGFB1
38congenital chloride diarrhea10.1ACE, IL6
39heterophyiasis10.0ACE, IL6
40idiopathic membranous glomerulonephritis10.0ACE, AGT, AGTR1
41cryptorchidism10.0
42renal tubular acidosis10.0
43hypospadias10.0
44bladder neck obstruction10.0
45prostatitis10.0
46urethral diverticulum10.0
47oral mucosa leukoplakia10.0ACE, IL6
48iga glomerulonephritis10.0ACE, AGT, AGTR1
49aortic dissection lentiginosis10.0ACE, AGT, AGTR1
50voyeurism10.0ACE, AGT, AGTR1

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Symptoms for Posterior Urethral Valves

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Drugs & Therapeutics for Posterior Urethral Valves

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Drugs for Posterior Urethral Valves (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Fentanylapproved, illicit, investigationalPhase 2705437-38-73345
Synonyms:
1-Phenethyl-4-(N-phenylpropionamido)piperidine
1-Phenethyl-4-N-propionylanilinopiperidine
437-38-7
5-22-08-00049 (Beilstein Handbook Reference)
80832-90-2
990-73-8 (citrate)
AC1L1FQ2
Abstral
Actiq
BIDD:GT0555
BRN 0494484
CHEBI:119915
CHEMBL596
CID3345
D00320
DB00813
Duragesic
Duragesic (TN)
Duragesic-100
Duragesic-12
Duragesic-25
Duragesic-50
Duragesic-75
Durogesic
EINECS 207-113-6
Fentanest
Fentanil
Fentanil [DCIT]
Fentanila
Fentanila [INN-Spanish]
Fentanilo
Fentanyl
Fentanyl (JAN/USAN/INN)
Fentanyl - Novaplus
Fentanyl Citrate
Fentanyl [INN:BAN]
Fentanyl citrate
Fentanyl-100
 
Fentanyl-12
Fentanyl-25
Fentanyl-50
Fentanyl-75
Fentanylum
Fentanylum [INN-Latin]
HSDB 3329
IONSYS
JNS020QD
L001275
LS-124439
Lazanda
Matrifen
MolPort-003-847-369
N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-Phenethyl-4-piperidyl)propionanilide
N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide
N-Phenethyl-4-(N-propionylanilino)piperidine
N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
NCGC00168252-01
Nasalfent
Oprea1_152073
Oprea1_207148
PDSP1_000860
PDSP2_000846
Pentanyl
Phentanyl
Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)
R 4263
Rapinyl
Sentonil
Sublimase
Sublimaze
Subsys
UNII-UF599785JZ
fentanyl
2AnestheticsPhase 2, Phase 17385
3Antitubercular Agents1061
4Anti-Infective Agents17220
5Anti-Bacterial Agents9140
6Antibiotics, Antitubercular5971

Interventional clinical trials:

idNameStatusNCT IDPhase
1Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract ObstructionsNot yet recruitingNCT01552824Phase 2
2Fetal Cystoscopy for Lower Urinary Tract ObstructionRecruitingNCT02446184Phase 1
3CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral ValvesRecruitingNCT01537601
4Standardized Prenatal Clinical Care for LUTORecruitingNCT02315521

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

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Anatomical Context for Posterior Urethral Valves

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MalaCards organs/tissues related to Posterior Urethral Valves:

33
Lung, Kidney, Heart, Prostate, Liver, Thyroid, T cells

Animal Models for Posterior Urethral Valves or affiliated genes

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MGI Mouse Phenotypes related to Posterior Urethral Valves:

38 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4ACE, AGTR2, IL6, TGFB1, TNF
2MP:00053888.3ACE2, IL6, TBX18, TGFB1, TNF
3MP:00053708.2ACE, AGT, IL6, TGFB1, TNF
4MP:00053818.1ACE2, AGTR2, IL6, TGFB1, TNF
5MP:00053867.2ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
6MP:00036317.2AGT, AGTR1, AGTR2, IL6, TBX18, TGFB1
7MP:00053757.2ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
8MP:00053696.9ACE2, AGT, AGTR2, IL6, TBX18, TGFB1
9MP:00053676.9ACE, ACE2, AGT, AGTR1, AGTR2, IL6
10MP:00053876.9ACE, ACE2, AGT, AGTR1, IL6, TGFB1
11MP:00053766.5ACE, ACE2, AGT, AGTR1, AGTR2, IL6
12MP:00107686.1ACE, ACE2, AGT, AGTR1, AGTR2, IL6
13MP:00053786.0ACE, ACE2, AGT, AGTR1, AGTR2, IL6
14MP:00053855.8ACE, ACE2, AGT, AGTR1, AGTR2, IL6

Publications for Posterior Urethral Valves

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Articles related to Posterior Urethral Valves:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Vesicostomy and Colostomy in a Premature Neonate With Posterior Urethral Valves, Bilateral Dysplastic Kidneys, and High Imperforate Anus: The Challenge of Stoma Placement. (27015939)
2016
2
Neonatal presentation of posterior urethral valves and tethered spinal cord. (25073498)
2014
3
Urinary tract tuberculosis in a child with late presentation posterior urethral valves. (24529021)
2014
4
Renal Parenchymal Area and Risk of ESRD in Boys with Posterior Urethral Valves. (24311709)
2013
5
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
6
Posterior urethral valves: Persistent renin angiotensin system activation after valve ablation and role of pre-emptive therapy with angiotensin converting enzyme-inhibitors on renal recovery. (23798811)
2013
7
Posterior Urethral Valves; A single Center Experience. (24800012)
2013
8
Risk factors associated with chronic kidney disease in patients with posterior urethral valves without prenatal hydronephrosis. (21527193)
2011
9
A rare cause of ascites in a newborn: posterior urethral valve. (20158664)
2010
10
Etiopathogenesis and management of bladder dysfunction in patients with posterior urethral valves. (21369376)
2010
11
A follow-up study of children with posterior urethral valve. (20835319)
2010
12
Prognostic value of serum creatinine levels in children with posterior urethral valves treated by primary valve ablation. (19581129)
2010
13
Posterior urethral valves: a single center experience over 7 years. (19184051)
2009
14
Abnormal antenatal sonogram: an indicator of disease severity in children with posterior urethral valves. (19632082)
2009
15
Posterior urethral valves are often associated with cryptorchidism and inguinal hernias. (18554641)
2008
16
Concordant posterior urethral valves in male monochorionic twins with secondary prune belly syndrome. (19213520)
2008
17
Re: The effects of bladder neck incision on urodynamic abnormalities of children with posterior urethral valves. A. M. Kajbafzadeh, S. Payabvash and G. Karimian. J Urol 2007; 178: 2142-2149. (18436260)
2008
18
Posterior urethral valves in three siblings: a case report and review of the literature. (18240166)
2008
19
Renal transplantation in children with posterior urethral valves. (16491414)
2006
20
The impact of late presentation of posterior urethral valves on bladder and renal function. (16600793)
2006
21
Long-term followup of bilateral high (sober) urinary diversion in patients with posterior urethral valves and its effect on bladder function. (15821568)
2005
22
Myogenic bladder decompensation in boys with a history of posterior urethral valves is caused by secondary bladder neck obstruction? (15963137)
2005
23
Initial and long-term management of posterior urethral valves. (15558286)
2004
24
Long-term outcome of posterior urethral valves ablation using the Mohan's urethral valvotome. (15171523)
2004
25
Posterior urethral valves: prognostic factors. (12699486)
2003
26
Incidental adult posterior urethral valve without clinical features. (15072500)
2003
27
Posterior urethral valves and mirror image anomalies in monozygotic twins. (12210353)
2002
28
Xanthogranulomatous pyelonephritis in a dysplastic kidney with reflux associated with posterior urethral valves. (11832763)
2002
29
Prospective analysis of renal function and somatic growth in neonatal posterior urethral valves. (12369006)
2002
30
Posterior urethral valves. (12696266)
2002
31
Posterior urethral valves. (11294257)
2001
32
Increased urinary transforming growth factor-beta(1) excretion in children with posterior urethral valves. (10925100)
2000
33
The long-term complications of posterior urethral valves. (10330919)
1999
34
Applications of the KTP laser in the treatment of posterior urethral valves, ureteroceles, and urethral strictures in the pediatric patient. (9728129)
1998
35
The management of unilateral poorly functioning kidneys in patients with posterior urethral valves. (9258129)
1997
36
The long-term outcome of posterior urethral valves treated with primary valve ablation and observation. (8627873)
1996
37
Mercapto-acetyltriglycine (MAG 3) renography and indirect radionuclide cystography in posterior urethral valves. (7827852)
1994
38
Re: Delayed presentation of posterior urethral valves. S. A. Merchant et al. Br. J. Urol., 69, 318-319, 1992. (10071574)
1993
39
Unusual presentation of adult posterior urethral valve. (1422693)
1992
40
Re: Renal transplantation in children with posterior urethral valves. (1294129)
1992
41
Influence of initial therapy on progression of renal failure and body growth in children with posterior urethral valves. (1640516)
1992
42
99mTc DTPA scintigraphy compared with intravenous urography in the follow-up of posterior urethral valves. (3322473)
1987
43
Posterior urethral valves in Saudi Arabia. (3833844)
1985
44
Posterior urethral valves in the British Isles: a multicenter B.A.P.S. review. (6834230)
1983
45
Observations on persistently dilated ureter after posterior urethral valve ablation. (7112792)
1982
46
Major and minor complications of posterior urethral valves. (7288943)
1981
47
The protean aspects of posterior urethral valves. (7321118)
1981
48
Posterior urethral valves in siblings. (1268469)
1976
49
3 case reports of posterior urethral valves with varied presentations. (1021125)
1976
50

Variations for Posterior Urethral Valves

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Expression for genes affiliated with Posterior Urethral Valves

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Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for genes affiliated with Posterior Urethral Valves

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Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathwaysScoreTop Affiliating Genes
19.6ACE, ACE2
29.6ACE, ACE2
39.6TGFB1, TNF
49.3IL6, TGFB1
59.3IL6, TGFB1
69.1IL6, TNF
79.1ACE, AGT, AGTR1
8
Show member pathways
9.0ACE, ACE2, AGT
99.0AGT, TGFB1, TNF
108.8IL6, TGFB1, TNF
118.8IL6, TGFB1, TNF
128.8IL6, TGFB1, TNF
138.8IL6, TGFB1, TNF
148.8IL6, TGFB1, TNF
158.8IL6, TGFB1, TNF
168.8IL6, TGFB1, TNF
178.8IL6, TGFB1, TNF
188.8IL6, TGFB1, TNF
19
Show member pathways
8.8IL6, TGFB1, TNF
208.8IL6, TGFB1, TNF
21
Show member pathways
8.4ACE, IL6, TGFB1, TNF
22
Show member pathways
8.4ACE, IL6, TGFB1, TNF
238.3AGTR1, IL6, TGFB1, TNF
24
Show member pathways
8.2AGT, AGTR2, IL6, TGFB1
258.1AGT, IL6, TGFB1, TNF
26
Show member pathways
7.7ACE, ACE2, AGT, AGTR1, AGTR2, TGFB1
27
Show member pathways
7.4ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
28
Show member pathways
7.3AGT, AGTR1, AGTR2, IL6, TGFB1, TNF

GO Terms for genes affiliated with Posterior Urethral Valves

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Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:003294310.4ACE, TGFB1
2positive regulation of protein complex assemblyGO:003133410.2TGFB1, TNF
3regulation of renal output by angiotensinGO:000201910.2ACE, AGT
4positive regulation of superoxide anion generationGO:003293010.1AGT, TGFB1
5regulation of blood vessel size by renin-angiotensinGO:000203410.1AGT, AGTR1
6positive regulation of cytokine secretionGO:005071510.1AGTR2, TNF
7receptor biosynthetic processGO:003280010.1ACE2, TNF
8positive regulation of cholesterol esterificationGO:001087310.1AGT, AGTR1
9G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:000719910.1AGT, AGTR2
10negative regulation of neurotrophin TRK receptor signaling pathwayGO:005138710.1AGT, AGTR2
11renin-angiotensin regulation of aldosterone productionGO:000201810.1AGT, AGTR2
12negative regulation of myoblast differentiationGO:004566210.1TGFB1, TNF
13protein import into nucleus, translocationGO:000006010.0TGFB1, TNF
14positive regulation of macrophage derived foam cell differentiationGO:001074410.0AGT, AGTR1
15positive regulation of renal sodium excretionGO:00358159.9AGT, AGTR2
16positive regulation of reactive oxygen species metabolic processGO:20003799.9AGT, AGTR1
17regulation of blood pressureGO:00082179.9AGT, AGTR2
18epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.8IL6, TNF
19positive regulation of cytokine productionGO:00018199.8AGT, TNF
20cell growth involved in cardiac muscle cell developmentGO:00610499.7AGT, AGTR2
21negative regulation of lipid storageGO:00108889.7IL6, TNF
22positive regulation of branching involved in ureteric bud morphogenesisGO:00901909.7AGT, AGTR2, TGFB1
23positive regulation of cellular protein metabolic processGO:00322709.7AGT, AGTR1, TGFB1
24blood vessel remodelingGO:00019749.6ACE, AGT, AGTR2
25positive regulation of fibroblast proliferationGO:00481469.5AGT, TGFB1
26negative regulation of fat cell differentiationGO:00455999.2IL6, TGFB1, TNF
27T cell activationGO:00421109.2IL6, TGFB1
28cell surface receptor signaling pathwayGO:00071669.2AGT, AGTR2, TNF
29positive regulation of peptidyl-serine phosphorylationGO:00331389.2IL6, TGFB1, TNF
30negative regulation of gene expressionGO:00106299.1AGT, TGFB1, TNF
31positive regulation of protein kinase B signalingGO:00518979.1IL6, TGFB1, TNF
32positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.1AGT, IL6, TGFB1
33cellular response to dexamethasone stimulusGO:00715498.9AGTR2, IL6, TGFB1
34regulation of vasoconstrictionGO:00192298.8ACE, AGT, AGTR1
35positive regulation of NF-kappaB transcription factor activityGO:00510928.7AGT, IL6, TNF
36positive regulation of nitric oxide biosynthetic processGO:00454298.6AGT, AGTR2, IL6, TNF
37inflammatory responseGO:00069548.4AGTR2, IL6, TGFB1, TNF
38positive regulation of transcription, DNA-templatedGO:00458938.0AGT, AGTR2, IL6, TGFB1, TNF
39regulation of cell proliferationGO:00421278.0ACE2, AGT, AGTR1, TGFB1, TNF

Sources for Posterior Urethral Valves

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet