PUV
MCID: PST041
MIFTS: 47

Posterior Urethral Valves (PUV) malady

Categories: Rare diseases, Nephrological diseases, Fetal diseases

Aliases & Classifications for Posterior Urethral Valves

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Sources:
30ICD10, 31ICD10 via Orphanet, 48NIH Rare Diseases, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Posterior Urethral Valves:

Name: Posterior Urethral Valves 48
Congenital Posterior Urethral Valves 68
 
Posterior Urethral Valve 54
Puv 54

Characteristics:

Orphanet epidemiological data:

54
posterior urethral valve:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Australia); Age of onset: Antenatal,Neonatal; Age of death: early childhood

Classifications:



External Ids:

Orphanet54 ORPHA93110
UMLS via Orphanet69 C0238506, C0542520
ICD10 via Orphanet31 Q64.2
ICD1030 Q64.2

Summaries for Posterior Urethral Valves

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Wikipedia:71 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards based summary: Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to tuberculosis and xanthogranulomatous pyelonephritis. An important gene associated with Posterior Urethral Valves is ACE (Angiotensin I Converting Enzyme), and among its related pathways are RXR and RAR heterodimerization with other nuclear receptor and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include lung, kidney and prostate, and related mouse phenotypes are Decreased substrate adherent cell growth and neoplasm.

Related Diseases for Posterior Urethral Valves

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Diseases in the Anterior Urethral Valve family:

posterior urethral valves

Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis29.9ACE, IL6, TNF
2xanthogranulomatous pyelonephritis29.5ACE, AGTR1, IL6, TNF
3congenital anomalies of kidney and urinary tract11.2
4urethritis11.1
5pelviureteric junction obstruction11.1
6vesicoureteral reflux10.3
7vps11-related autosomal recessive hypomyelinating leukodystrophy10.3IL6, TNF
8severe hemophilia a10.3ACE, TNF
9cardiac sarcoidosis10.2ACE, TNF
10dermatosis papulosa nigra10.2ACE, TNF
11penile cancer, childhood10.2ACE, AGT
12dyslexia 510.2IL6, TNF
13bilateral parasagittal parieto-occipital polymicrogyria10.2TGFB1, TNF
14aortic atherosclerosis10.2IL6, TNF
15degenerative disc disease10.2IL6, TNF
16prune belly syndrome10.2
17distal trisomy 14q10.2TGFB1, TNF
18unilateral multicystic dysplastic kidney10.2IL6, TNF
19peripheral artery disease10.2ACE, TGFB1, TNF
20thymic neuroendocrine carcinoma10.2IL6, TNF
21skin conditions10.2ACE, TGFB1, TNF
22anal paget's disease10.2IL6, TGFB1, TNF
23hypoparathyroidism-retardation-dysmorphism syndrome10.2IL6, TGFB1, TNF
24swine influenza10.2IL6, TNF
25rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies10.2IL6, TGFB1, TNF
26alcoholic hepatitis10.2ACE, IL6, TNF
27hereditary night blindness10.2IL6, TGFB1, TNF
28oppositional defiant disorder10.2ACE, IL6, TNF
29idiopathic panuveitis10.2ACE, AGTR2, TGFB1
30choroiditis10.2ACE, IL6, TNF
31labyrinthitis10.2IL6, TGFB1, TNF
32immunoglobulin g deficiency10.2IL6, TGFB1, TNF
33myiasis10.2IL6, TGFB1, TNF
34drug dependence10.2IL6, TNF
35biliary cirrhosis, primary, 210.2ACE, TGFB1, TNF
36limb ischemia10.2ACE, IL6, TNF
37burns10.2IL6, TGFB1, TNF
38diabetic encephalopathy10.2ACE, IL6, TNF
39baritosis10.2IL6, TGFB1, TNF
40splenic marginal zone lymphoma10.2IL6, TGFB1, TNF
41transient tic disorder10.1IL6, TNF
42lichen disease10.1IL6, TGFB1, TNF
43sclerosing adenosis of breast10.1IL6, TGFB1, TNF
44pigmentation disease10.1IL6, TGFB1, TNF
45bone angioendothelial sarcoma10.1IL6, TGFB1, TNF
46down syndrome10.1
47peroneal neuropathy10.1ACE, IL6, TNF
48detrusor sphincter dyssynergia10.1IL6, TGFB1, TNF
49nervous system cancer10.1IL6, TGFB1, TNF
50body dysmorphic disorder10.1ACE, IL6, TNF

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Symptoms & Phenotypes for Posterior Urethral Valves

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GenomeRNAi Phenotypes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00193-A-39.6AGTR1, AGTR2, DSTYK

MGI Mouse Phenotypes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5ACE, AGTR2, IL6, TGFB1, TNF
2MP:00107718.8ACE2, AGTR2, IL6, TBX18, TGFB1, TNF
3MP:00053758.3ACE, AGT, AGTR1, AGTR2, IL6, SLC3A1
4MP:00053698.2ACE2, AGT, AGTR2, IL6, TBX18, TGFB1
5MP:00053878.2ACE, ACE2, AGT, AGTR1, IL6, SLC3A1
6MP:00053767.8ACE, ACE2, AGT, AGTR1, AGTR2, IL6
7MP:00053857.6ACE, ACE2, AGT, AGTR1, AGTR2, IL6
8MP:00053787.2ACE, ACE2, AGT, AGTR1, AGTR2, IL6
9MP:00107687.1ACE, ACE2, AGT, AGTR1, AGTR2, IL6
10MP:00053676.6ACE, ACE2, AGT, AGTR1, AGTR2, IL6

Drugs & Therapeutics for Posterior Urethral Valves

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Drugs for Posterior Urethral Valves (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Fentanylapproved, illicit, investigational, vet_approvedPhase 2821437-38-73345
Synonyms:
1-Phenethyl-4-(N-phenylpropionamido)piperidine
1-Phenethyl-4-N-propionylanilinopiperidine
1-phenethyl-4-N-propionylanilinopiperidine
437-38-7
5-22-08-00049 (Beilstein Handbook Reference)
80832-90-2
990-73-8 (citrate)
AC1L1FQ2
Actiq
BIDD:GT0555
BRN 0494484
CHEBI:119915
CHEMBL596
CID3345
D00320
DB00813
Duragesic
Duragesic (TN)
Duragesic-100
Duragesic-12
Duragesic-25
Duragesic-50
Duragesic-75
Durogesic
EINECS 207-113-6
Fentanest
Fentanil
Fentanil [DCIT]
Fentanila
Fentanila [INN-Spanish]
Fentanilo
Fentanyl
Fentanyl (JAN/USAN/INN)
Fentanyl CII
Fentanyl [INN:BAN]
Fentanyl citrate
Fentanyl-100
Fentanyl-12
Fentanyl-25
 
Fentanyl-50
Fentanyl-75
Fentanylum
Fentanylum [INN-Latin]
HSDB 3329
IONSYS
JNS020QD
L001275
LS-124439
Matrifen
MolPort-003-847-369
N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-Phenethyl-4-piperidyl)propionanilide
N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidyl)propionanilide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide
N-Phenethyl-4-(N-propionylanilino)piperidine
N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenethyl-4-(N-propionylanilino)piperidine
N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
NCGC00168252-01
Nasalfent
Oprea1_152073
Oprea1_207148
PDSP1_000860
PDSP2_000846
Pentanyl
Phentanyl
Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)
R 4263
Rapinyl
Sentonil
Sublimase
Sublimaze
UNII-UF599785JZ
fentanyl
2
PancuroniumapprovedPhase 2315500-66-027350, 441289
Synonyms:
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(1-methylpiperidinium-1-yl)androstane dibromide
1,1'-(3,17-Bis(acetyloxy)androstane-2,16-diyl)bis(1-methylpiperidinium) dibromide
1,1'-(3alpha,17beta-Bis(acetyloxy)-5alpha-androstane-2beta,16beta-diyl)bis(1-methylpiperidinium) dibromide
1,1'-(3alpha,17beta-Dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methylpiperidinium) dibromide diacetate
1,1'-([2beta,3alpha,5alpha,16beta,17beta]-3,17-Bis[acetyloxy]androstane-2,16-diyl)bis(1-methylpiperidinium) dibromide
1,1'-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide
15500-66-0
2beta,16beta-Dipiperidino-5alpha-androstane-3alpha,17beta-diol diacetate dimethobromide
2beta,16beta-Dipiperidino-5alpha-androstane-3alpha,17beta-dioldiacetatedimethobromide
3-alpha,17-beta-Diacetoxy-2-beta,16-beta-dipiperidino-5-alpha-androstane dimethobromide
3alpha,17beta-Diacetoxy-2beta,16beta-dipiperidino-5alpha-androstane dimethobromide
3alpha,17beta-diacetoxy-2beta,16beta-bis(1-methylpiperidinium-1-yl)-5alpha-androstane
3alpha,17beta-diacetoxy-2beta,16beta-bis(1-methylpiperidinium-1-yl)-5alpha-androstane dibromide
5alpha-Androstan-3alpha,17beta-diol, 2beta,16beta-dipipecolinio-, dibromide, diacetate
AB00384328
AC1L1D1A
AC1L9AWJ
Ambap15500-66-0
BPBio1_001372
BSPBio_001247
Bromure de pancuronium
Bromure de pancuronium [INN-French]
Bromure de pancuronium [inn-french]
Bromuro de pancuronio
Bromuro de pancuronio [INN-Spanish]
Bromuro de pancuronio [inn-spanish]
C07551
C35H60N2O4
CHEBI:7907
CHEBI:7908
CHEMBL1200757
CHEMBL185073
CID27350
CID441289
D00492
DB01337
EINECS 239-532-5
EU-0100887
HMS1571O09
HMS2089M07
 
HSDB 3244
LS-116480
Lopac0_000887
Mioblock
MolPort-003-938-961
NA 97
NCGC00023037-03
NCGC00023037-04
NCGC00023037-05
NSC 293162
NSC293162
ORG NA 97
ORG-NA 97
P 1918
P1918_SIGMA
PANCURONIUM BROMIDE
Pancuronii bromidum
Pancuronii bromidum [INN-Latin]
Pancuronium
Pancuronium bromide
Pancuronium bromide (JP15/USAN/INN)
Pancuronium bromide [USAN:BAN:INN:JAN]
Pancuronium dibromide
Pavulon
Pavulon (TN)
Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl)-, dibromide
Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl-, dibromide
Piperidinium, 1,1'-(2-beta,16-beta-(3-alpha,17-beta-dihydroxy-5-alpha-androstanylene))bis(1-methyl-, dibromide, diacetate
Piperidinium, 1,1'-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methyl-, dibromide, diacetate
Piperidinium, 1,1'-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methyl-, dibromide, diacetate (8CI)
Piperidinium, 1,1'-[(2.beta.,3.alpha.,5.alpha.,16.beta.,17.beta.)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide
Poncuronium bromide
Prestwick0_001034
Prestwick1_001034
Prestwick2_001034
Prestwick3_001034
S2497_Selleck
SPBio_003098
UNII-U9LY9Y75X2
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate dibromide
pancuronium
3AnestheticsPhase 29596
4Antitubercular Agents1343
5Anti-Infective Agents22062
6Anti-Bacterial Agents11226
7Antibiotics, Antitubercular7180

Interventional clinical trials:

idNameStatusNCT IDPhase
1Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract ObstructionsNot yet recruitingNCT01552824Phase 2
2CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral ValvesRecruitingNCT01537601
3Standardized Prenatal Clinical Care for LUTORecruitingNCT02315521
4Validation of a Fetal Urine Peptidome-based Classifier to Predict Post-natal Renal Function in Posterior Urethral ValvesNot yet recruitingNCT03116217
5Fetal Cystoscopy for Lower Urinary Tract ObstructionTerminatedNCT02446184

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

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Anatomical Context for Posterior Urethral Valves

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MalaCards organs/tissues related to Posterior Urethral Valves:

36
Lung, Kidney, Prostate, Testes, Spinal cord

Publications for Posterior Urethral Valves

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Articles related to Posterior Urethral Valves:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Posterior urethral valves (PUV) in pediatric practice - Promoting methods to understand how to diagnose and incise (PUV). (26921022)
2016
2
Vesicostomy and Colostomy in a Premature Neonate With Posterior Urethral Valves, Bilateral Dysplastic Kidneys, and High Imperforate Anus: The Challenge of Stoma Placement. (27015939)
2016
3
Outcome of Antenatally Presenting Posterior Urethral Valves (PUV) in Children. (28031548)
2016
4
DNA copy number variants: A potentially useful predictor of early onset renal failure in boys with posterior urethral valves. (27160979)
2016
5
Posterior urethral valves: how the study of fetal micturition can help to reach the diagnosis? (27351949)
2016
6
Posterior urethral valves and vesicoureteral reflux: can prenatal ultrasonography distinguish between these two conditions in male fetuses? (27374758)
2016
7
Genetic Basis of Posterior Urethral Valves Inheritance. (27261184)
2016
8
Posterior urethral valves: are neonatal imaging findings predictive of renal function during early childhood? (27401742)
2016
9
Challenges in Predicting Renal Outcomes in Boys with Posterior Urethral Valves. (27311411)
2016
10
Predicting risk of chronic kidney disease in infants and young children with posterior urethral valves at time of diagnosis: Objective analysis of initial ultrasound kidney characteristics and validation of parenchyma area as forecasters of renal reserve. (27017936)
2016
11
Re: Combined Creatinine Velocity and Nadir Creatinine: A Reliable Predictor of Renal Outcome in Neonatally Diagnosed Posterior Urethral Valves. (26887751)
2016
12
Rare copy number variants implicated in posterior urethral valves. (26663319)
2016
13
Controlled Outcomes for Achievement of Urinary Continence among Boys Treated for Posterior Urethral Valves. (26964916)
2016
14
Re: Nadir Creatinine in Posterior Urethral Valves: How High is Low Enough? (26853033)
2016
15
Re: Tran et al.: anterior urethral valve associated with posterior urethral valves: report of 2 cases and review of the literature (Urology 2014;84:469-471). (25733298)
2015
16
Posterior urethral valves: Metabolic consequences in a cohort of patients. (26096436)
2015
17
Antenatal Determinants of Long-Term Kidney Outcome in Boys with Posterior Urethral Valves. (26375276)
2015
18
Posterior urethral valve with unilateral vesicoureteral reflux and patent urachus: A rare combination of urinary tract anomaliess. (25836363)
2015
19
Posterior Urethral Valves in Children: Pattern of Presentation and Outcome of Initial Treatment in Ile-Ife, Nigeria. (26425072)
2015
20
Concomitant anterior and posterior urethral valves in pediatrics: A single center experience over 12a88years and long-term follow up after endoscopic treatment. (25689730)
2015
21
Presentation, management, and outcome of posterior urethral valves in a Nigerian tertiary hospital. (25659544)
2015
22
Late diagnosis of posterior urethral valves. (26112258)
2015
23
Concomitant Anterior and Posterior Urethral Valves: A Comprehensive Review of Literature. (25863834)
2015
24
Nadir creatinine in posterior urethral valves: How high is low enough? (26292912)
2015
25
Posterior urethral valves: Risk factors for progression to renal failure. (26705688)
2015
26
Study of prognostic significance of antenatal ultrasonography and renin angiotensin system activation in predicting disease severity in posterior urethral valves. (25829668)
2015
27
Split-cuff nipple technique of ureteral reimplantation in children with thick-walled bladders due to posterior urethral valves. (25444631)
2015
28
Combined creatinine velocity and nadir creatinine: A reliable predictor of renal outcome in neonatally diagnosed posterior urethral valves. (26062970)
2015
29
Laser Ablation of Posterior Urethral Valves by Fetal Cystoscopy. (25614247)
2015
30
Urological fistulas after fetal cystoscopic laser ablation of posterior urethral valves - surgical technical aspects. (24817027)
2014
31
Posterior urethral polyp with type I posterior urethral valves: a rare association in a neonate. (24767515)
2014
32
The management of vesicoureteral reflux in the setting of posterior urethral valve with emphasis on bladder function and renal outcome: a single center cohort study. (24149109)
2014
33
Neonatal presentation of posterior urethral valves and tethered spinal cord. (25073498)
2014
34
Re: long-term bladder function, fertility and sexual function in patients with posterior urethral valves treated in infancy. (24331507)
2014
35
Epidemiology and demography of recently diagnosed cases of posterior urethral valves. (25198372)
2014
36
Late presentation of posterior urethral valves. (24906275)
2014
37
Urinary tract tuberculosis in a child with late presentation posterior urethral valves. (24529021)
2014
38
Population-specific serum creatinine centiles in neonates with posterior urethral valves already predict long-term renal outcome. (25000449)
2014
39
Anterior urethral valve associated with posterior urethral valves: report of 2 cases and review of the literature. (24958476)
2014
40
Residual valve and stricture after posterior urethral valve ablation: how to evaluate? (22364895)
2013
41
Long-term consequences of posterior urethral valves. (23871421)
2013
42
Posterior Urethral Valves; A single Center Experience. (24800012)
2013
43
Utilization of computer enhanced visual learning (CEVL) method improves endoscopic diagnosis of posterior urethral valves (PUV). (22981142)
2013
44
Bilateral epididymitis in a child with undiagnosed posterior urethral valves. (23477755)
2013
45
Posterior urethral valves: Persistent renin angiotensin system activation after valve ablation and role of pre-emptive therapy with angiotensin converting enzyme-inhibitors on renal recovery. (23798811)
2013
46
The impact of posterior urethral valves on adult quality of life. (22878058)
2013
47
Newborn radiographic clues for undiagnosed posterior urethral valves. (23043682)
2013
48
Spontaneous rupture of kidney due to posterior urethral valve-diagnostic difficulties. (23795264)
2013
49
Early outcome following diathermy versus cold knife ablation of posterior urethral valves. (22417679)
2013
50
Long-term bladder function, fertility and sexual function in patients with posterior urethral valves treated in infancy. (22154080)
2013

Variations for Posterior Urethral Valves

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Expression for genes affiliated with Posterior Urethral Valves

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Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for genes affiliated with Posterior Urethral Valves

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Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathwaysScoreTop Affiliating Genes
19.9TGFB1, TNF
29.8IL6, TGFB1
39.8IL6, TNF
49.8IL6, TNF
59.7ACE, ACE2
69.5IL6, TGFB1, TNF
79.5IL6, TGFB1, TNF
89.5IL6, TGFB1, TNF
99.5IL6, TGFB1, TNF
109.5IL6, TGFB1, TNF
119.5IL6, TGFB1, TNF
12
Show member pathways
9.5IL6, TGFB1, TNF
139.5IL6, TGFB1, TNF
149.5IL6, TGFB1, TNF
159.5IL6, TGFB1, TNF
169.5IL6, TGFB1, TNF
179.5IL6, TGFB1, TNF
18
Show member pathways
9.4AGT, TGFB1, TNF
19
Show member pathways
9.2ACE, IL6, TGFB1, TNF
209.2ACE, AGT, AGTR1
21
Show member pathways
9.2ACE, ACE2, AGT
229.1AGT, IL6, TGFB1, TNF
239.0AGTR1, IL6, TGFB1, TNF
24
Show member pathways
9.0AGTR1, IL6, TGFB1, TNF
25
Show member pathways
8.2ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
26
Show member pathways
8.1AGT, AGTR1, AGTR2, IL6, TGFB1, TNF
27
Show member pathways
8.0ACE, ACE2, AGT, AGTR1, AGTR2, TGFB1

GO Terms for genes affiliated with Posterior Urethral Valves

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Cellular components related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.6ACE, ACE2, AGT, AGTR2, IL6, TGFB1
2extracellular spaceGO:00056158.2ACE, ACE2, AGT, IL6, TGFB1, TNF

Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:003294310.7ACE, TGFB1
2negative regulation of mitotic cell cycleGO:004593010.6TGFB1, TNF
3negative regulation of myoblast differentiationGO:004566210.6TGFB1, TNF
4neutrophil mediated immunityGO:000244610.6ACE, IL6
5positive regulation of mononuclear cell migrationGO:007167710.6TGFB1, TNF
6epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.6IL6, TNF
7positive regulation of protein complex assemblyGO:003133410.6TGFB1, TNF
8negative regulation of lipid storageGO:001088810.6IL6, TNF
9positive regulation of chemokine productionGO:003272210.6IL6, TNF
10negative regulation of blood vessel endothelial cell migrationGO:004353710.5AGTR2, TGFB1
11protein import into nucleus, translocationGO:000006010.5TGFB1, TNF
12positive regulation of cytokine secretionGO:005071510.5AGTR2, TNF
13positive regulation of protein tyrosine kinase activityGO:006109810.5ACE, AGT
14angiotensin catabolic process in bloodGO:000200510.4ACE, ACE2
15positive regulation of cytokine productionGO:000181910.4AGT, TNF
16positive regulation of superoxide anion generationGO:003293010.4AGT, TGFB1
17cell growth involved in cardiac muscle cell developmentGO:006104910.4AGT, AGTR2
18cellular sodium ion homeostasisGO:000688310.4AGT, AGTR2
19G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:000719910.4AGT, AGTR2
20positive regulation of vascular smooth muscle cell proliferationGO:190470710.4AGT, TNF
21negative regulation of neurotrophin TRK receptor signaling pathwayGO:005138710.4AGT, AGTR2
22nitric oxide mediated signal transductionGO:000726310.4AGT, AGTR2
23positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.3AGT, AGTR2
24receptor-mediated virion attachment to host cellGO:004681310.3ACE, ACE2
25positive regulation of renal sodium excretionGO:003581510.3AGT, AGTR2
26angiotensin-activated signaling pathwayGO:003816610.3AGTR1, AGTR2
27receptor biosynthetic processGO:003280010.3ACE2, TNF
28positive regulation of vasodilationGO:004590910.3AGT, AGTR2
29angiotensin-mediated drinking behaviorGO:000305110.3ACE2, AGT
30negative regulation of fat cell differentiationGO:004559910.3IL6, TGFB1, TNF
31low-density lipoprotein particle remodelingGO:003437410.3AGT, AGTR1
32positive regulation of cholesterol esterificationGO:001087310.2AGT, AGTR1
33positive regulation of peptidyl-serine phosphorylationGO:003313810.2IL6, TGFB1, TNF
34positive regulation of macrophage derived foam cell differentiationGO:001074410.2AGT, AGTR1
35positive regulation of NAD(P)H oxidase activityGO:003386410.2AGT, AGTR1
36positive regulation of gap junction assemblyGO:190359810.2ACE2, AGT
37regulation of renal output by angiotensinGO:000201910.2ACE, AGT
38positive regulation of protein kinase B signalingGO:005189710.2IL6, TGFB1, TNF
39cellular response to dexamethasone stimulusGO:007154910.2AGTR2, IL6, TGFB1
40agingGO:000756810.1AGT, IL6, TGFB1
41regulation of blood vessel diameter by renin-angiotensinGO:000203410.1AGT, AGTR1
42blood vessel remodelingGO:000197410.1ACE, AGT, AGTR2
43positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.1AGT, IL6, TGFB1
44negative regulation of cell growthGO:003030810.1AGT, AGTR2, TGFB1
45positive regulation of branching involved in ureteric bud morphogenesisGO:009019010.1AGT, AGTR2, TGFB1
46regulation of renal sodium excretionGO:003581310.0AGT, AGTR1
47angiotensin maturationGO:000200310.0ACE, ACE2, AGT
48kidney developmentGO:000182210.0ACE, AGT, AGTR1
49regulation of blood pressureGO:00082179.9ACE, AGT, AGTR2
50positive regulation of cellular protein metabolic processGO:00322709.9AGT, AGTR1, TGFB1

Molecular functions related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.3ACE, AGTR1
2carboxypeptidase activityGO:000418010.3ACE, ACE2
3metallocarboxypeptidase activityGO:000418110.3ACE, ACE2
4peptidyl-dipeptidase activityGO:000824110.3ACE, ACE2
5angiotensin type II receptor activityGO:000494510.2AGTR1, AGTR2
6growth factor activityGO:000808310.0AGT, IL6, TGFB1
7protein heterodimerization activityGO:00469828.7AGTR1, SLC3A1, TBX18, TGFB1

Sources for Posterior Urethral Valves

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2CDC
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