MCID: PST041
MIFTS: 48

Posterior Urethral Valves malady

Rare diseases category

Summaries for Posterior Urethral Valves

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34MalaCards
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MalaCards: Posterior Urethral Valves is related to vesicoureteral reflux and urinary tract obstruction. An important gene associated with Posterior Urethral Valves is AGTR2 (angiotensin II receptor, type 2), and among its related pathways are A-beta Uptake and Degradation and A-beta Plaque Formation and APP Metabolism. The compounds cgp42112a and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and testes, and related mouse phenotypes are tumorigenesis and respiratory system.

Aliases & Classifications for Posterior Urethral Valves

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

posterior urethral valves 44 63


Related Diseases for Posterior Urethral Valves

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Symptoms for Posterior Urethral Valves

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Drugs & Therapeutics for Posterior Urethral Valves

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Posterior Urethral Valves

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Genetic Tests for Posterior Urethral Valves

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Anatomical Context for Posterior Urethral Valves

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34MalaCards
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MalaCards organs/tissues related to Posterior Urethral Valves:

34
Kidney, Prostate, Testes

Animal Models for Posterior Urethral Valves or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Posterior Urethral Valves:

38 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9TNF, TGFB1, ACE, IL6, AGTR2
2MP:00053887.9IL6, ACE2, TGFB1, TNF
3MP:00053817.9TNF, TGFB1, IL6, AGTR2
4MP:00053707.9TNF, TGFB1, ACE, IL6, AGT
5MP:00036317.8AGT, AGTR2, IL6, TGFB1, TNF
6MP:00053797.7TNF, TGFB1, ACE, IL6, AGTR2
7MP:00053757.6TNF, TGFB1, ACE, IL6, AGTR2, AGT
8MP:00053677.5TGFB1, ACE2, ACE, IL6, AGTR2, AGT
9MP:00053697.5TNF, TGFB1, ACE2, IL6, AGTR2, AGT
10MP:00053867.5TNF, TGFB1, ACE, IL6, AGTR2, AGT
11MP:00053877.4TNF, TGFB1, ACE, IL6, AGT, AGTR1
12MP:00053847.3TNF, TGFB1, ACE2, ACE, IL6, AGTR2
13MP:00053787.1TNF, TGFB1, ACE, IL6, AGTR2, AGT
14MP:00053856.7AGTR1, TNF, TGFB1, ACE2, ACE, IL6
15MP:00053766.7TNF, TGFB1, ACE2, ACE, IL6, AGTR2
16MP:00107686.7TNF, TGFB1, ACE2, ACE, IL6, AGTR2

Publications for Posterior Urethral Valves

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53PubMed
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Articles related to Posterior Urethral Valves:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Renal Parenchymal Area and Risk of ESRD in Boys with Posterior Urethral Valves. (24311709)
2013
2
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
3
Posterior urethral valves: Persistent renin angiotensin system activation after valve ablation and role of pre-emptive therapy with angiotensin converting enzyme-inhibitors on renal recovery. (23798811)
2013
4
Utilization of computer enhanced visual learning (CEVL) method improves endoscopic diagnosis of posterior urethral valves (PUV). (22981142)
2013
5
A rare cause of ascites in a newborn: posterior urethral valve. (20158664)
2010
6
Etiopathogenesis and management of bladder dysfunction in patients with posterior urethral valves. (21369376)
2010
7
A follow-up study of children with posterior urethral valve. (20835319)
2010
8
Prognostic value of serum creatinine levels in children with posterior urethral valves treated by primary valve ablation. (19581129)
2010
9
Posterior urethral valves: a single center experience over 7 years. (19184051)
2009
10
Abnormal antenatal sonogram: an indicator of disease severity in children with posterior urethral valves. (19632082)
2009
11
Posterior urethral valves are often associated with cryptorchidism and inguinal hernias. (18554641)
2008
12
Concordant posterior urethral valves in male monochorionic twins with secondary prune belly syndrome. (19213520)
2008
13
Re: The effects of bladder neck incision on urodynamic abnormalities of children with posterior urethral valves. A. M. Kajbafzadeh, S. Payabvash and G. Karimian. J Urol 2007; 178: 2142-2149. (18436260)
2008
14
Posterior urethral valves in three siblings: a case report and review of the literature. (18240166)
2008
15
Renal transplantation in children with posterior urethral valves. (16491414)
2006
16
The impact of late presentation of posterior urethral valves on bladder and renal function. (16600793)
2006
17
Long-term followup of bilateral high (sober) urinary diversion in patients with posterior urethral valves and its effect on bladder function. (15821568)
2005
18
Myogenic bladder decompensation in boys with a history of posterior urethral valves is caused by secondary bladder neck obstruction? (15963137)
2005
19
Initial and long-term management of posterior urethral valves. (15558286)
2004
20
Long-term outcome of posterior urethral valves ablation using the Mohan's urethral valvotome. (15171523)
2004
21
Posterior urethral valves: prognostic factors. (12699486)
2003
22
Incidental adult posterior urethral valve without clinical features. (15072500)
2003
23
Posterior urethral valves and mirror image anomalies in monozygotic twins. (12210353)
2002
24
Xanthogranulomatous pyelonephritis in a dysplastic kidney with reflux associated with posterior urethral valves. (11832763)
2002
25
Prospective analysis of renal function and somatic growth in neonatal posterior urethral valves. (12369006)
2002
26
Posterior urethral valves. (12696266)
2002
27
Increased urinary transforming growth factor-beta(1) excretion in children with posterior urethral valves. (10925100)
2000
28
The long-term complications of posterior urethral valves. (10330919)
1999
29
Spontaneous resolution of an in utero perirenal urinoma associated with posterior urethral valves. (10754132)
1999
30
Applications of the KTP laser in the treatment of posterior urethral valves, ureteroceles, and urethral strictures in the pediatric patient. (9728129)
1998
31
The management of unilateral poorly functioning kidneys in patients with posterior urethral valves. (9258129)
1997
32
The long-term outcome of posterior urethral valves treated with primary valve ablation and observation. (8627873)
1996
33
Long-term bladder dysfunction in boys with posterior urethral valves. (8877354)
1996
34
Posterior urethral valves: a report of five cases. (7634189)
1995
35
Mercapto-acetyltriglycine (MAG 3) renography and indirect radionuclide cystography in posterior urethral valves. (7827852)
1994
36
Re: Delayed presentation of posterior urethral valves. S. A. Merchant et al. Br. J. Urol., 69, 318-319, 1992. (10071574)
1993
37
Unusual presentation of adult posterior urethral valve. (1422693)
1992
38
Re: Renal transplantation in children with posterior urethral valves. (1294129)
1992
39
Influence of initial therapy on progression of renal failure and body growth in children with posterior urethral valves. (1640516)
1992
40
99mTc DTPA scintigraphy compared with intravenous urography in the follow-up of posterior urethral valves. (3322473)
1987
41
Posterior urethral valves in Saudi Arabia. (3833844)
1985
42
Posterior urethral valves in the British Isles: a multicenter B.A.P.S. review. (6834230)
1983
43
Observations on persistently dilated ureter after posterior urethral valve ablation. (7112792)
1982
44
Major and minor complications of posterior urethral valves. (7288943)
1981
45
The protean aspects of posterior urethral valves. (7321118)
1981
46
Nursing care study - posterior urethral valves. A sick baby makes a fresh start. (6898045)
1980
47
Posterior urethral valves. (588718)
1977
48
Posterior urethral valves in siblings. (1268469)
1976
49
3 case reports of posterior urethral valves with varied presentations. (1021125)
1976
50
Obstructive posterior urethral valves: the light at the end of the tunnel. (1113426)
1975

Variations for Posterior Urethral Valves

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Expression for genes affiliated with Posterior Urethral Valves

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Posterior Urethral Valves

Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for genes affiliated with Posterior Urethral Valves

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Sources:
51PathCards, 55R&D Systems, 61Thomson Reuters, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG, 52PharmGKB
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Pathways related to Posterior Urethral Valves according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ACE, ACE2
29.5ACE, ACE2
39.3IL6, TGFB1
4
Show member pathways
9.3IL6, TGFB1
5
Show member pathways
9.3IL6, TGFB1
6
Show member pathways
Serotonin Transporter Activity39
9.3TNF, AGT
79.1TNF, TGFB1
89.1TNF, TGFB1
9
Show member pathways
9.1TGFB1, TNF
10
Show member pathways
9.1ACE2, ACE, AGT
119.0TNF, IL6
129.0TNF, IL6
139.0IL6, TNF
149.0TNF, IL6
159.0IL6, TNF
169.0IL6, TNF
179.0TNF, IL6
188.8TNF, TGFB1, AGT
19
Show member pathways
8.8AGT, TGFB1, TNF
20
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.6TNF, IL6, AGTR1
21
Show member pathways
8.6AGT, AGTR2, IL6, TGFB1
22
Show member pathways
8.5TNF, TGFB1, IL6
23
Show member pathways
8.5IL6, TGFB1, TNF
248.5IL6, TGFB1, TNF
258.5IL6, TGFB1, TNF
26
Show member pathways
8.5IL6, TGFB1, TNF
27
Show member pathways
IL27-mediated signaling events39
8.5TNF, TGFB1, IL6
288.5IL6, TGFB1, TNF
298.5IL6, TGFB1, TNF
308.5TNF, TGFB1, IL6
318.5IL6, TGFB1, TNF
32
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.5TNF, TGFB1, IL6
338.5IL6, TGFB1, TNF
34
Show member pathways
8.5IL6, TGFB1, TNF
358.5IL6, TGFB1, TNF
368.1TNF, TGFB1, IL6, AGT
37
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
8.1IL6, ACE, TGFB1, TNF
38
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.1TNF, TGFB1, ACE, IL6
39
Show member pathways
7.8AGTR1, AGT, AGTR2, ACE, ACE2, TGFB1
40
Show member pathways
7.7TGFB1, ACE, IL6, AGTR2, AGT, AGTR1
41
Show member pathways
7.4TNF, TGFB1, IL6, AGTR2, AGT, AGTR1

Compounds for genes affiliated with Posterior Urethral Valves

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Posterior Urethral Valves according to GeneCards/GeneDecks:

(show top 50)    (show all 159)
idCompoundScoreTop Affiliating Genes
1cgp42112a469.7AGTR2, AGTR1, AGT
2aliskiren46 1210.6ACE, AGT, AGTR1
3temocaprilat469.6ACE, AGTR1
4eprosartan46 30 1211.6ACE, AGTR1, AGT
5olmesartan46 30 1211.6AGTR1, ACE, AGT
6chymostatin469.6AGTR1, ACE, AGT
7atenolol46 52 30 25 1213.5ACE, AGTR1, AGT
8diltiazem46 30 52 1212.5AGTR1, AGT, ACE
9enalaprilat469.5ACE, AGT, ACE2
10hydrochlorothiazide46 30 52 25 1213.5ACE, AGT, AGTR1
11eplerenone46 62 30 1212.4ACE, AGTR1, ACE2
12spironolactone46 62 30 52 1213.4ACE, AGTR2, AGTR1
13amlodipine46 52 25 1212.4ACE, AGT, AGTR1
14moexipril hydrochloride629.4ACE, ACE2
15saralasin469.3AGTR1, AGT, AGTR2, ACE
16pd12331946 3010.3AGTR2, AGTR1, ACE, AGT
17valsartan46 62 30 1212.3AGTR1, AGT, AGTR2, ACE
18telmisartan46 30 1211.3AGTR1, ACE, AGTR2, AGT
19irbesartan46 30 52 1212.3AGTR2, AGTR1, ACE, AGT
20enalapril46 52 1211.3AGTR1, AGT, ACE, AGTR2
21perindopril erbumine629.2ACE2, ACE
22angiotensin ii30 2510.2AGTR1, AGTR2, ACE, ACE2
23benazepril46 52 1211.2AGTR1, TGFB1, AGT, ACE
24lisinopril46 52 25 1212.1AGTR1, AGT, ACE, ACE2
25perindopril46 52 1211.1ACE, TGFB1, AGTR1, AGT
26nifedipine46 30 52 1212.0ACE, AGT, AGTR1, TGFB1
27ramipril46 1210.0AGTR1, ACE2, TGFB1, ACE
28candesartan46 52 30 1211.8AGTR2, ACE, TGFB1, AGT, AGTR1
29ang ii468.8TGFB1, AGTR1, ACE, AGT, AGTR2
30captopril46 62 52 30 1212.8AGTR1, ACE2, ACE, AGTR2, AGT
31losartan46 52 30 1211.8TGFB1, ACE, AGT, AGTR1, AGTR2
328-isoprostane468.7AGTR1, IL6, TNF
33gm-csf46 309.7TGFB1, TNF, IL6
34norepinephrine46 25 1210.6AGT, AGTR1, ACE, AGTR2, IL6
35atorvastatin46 52 30 25 1212.5IL6, TNF, ACE, AGT
36simvastatin46 52 62 30 25 1213.5AGT, AGTR1, IL6, TNF
37prostacyclin468.5ACE, AGTR2, TNF, AGT, AGTR1
38rosiglitazone30 46 52 25 1212.4AGTR1, IL6, TGFB1, TNF
39tgf beta1468.4IL6, TNF, TGFB1, AGTR1
40superoxide46 259.3ACE2, AGTR1, TNF, AGT, AGTR2
41prostaglandin468.3TNF, AGTR2, AGT, IL6, AGTR1
42cholesterol46 30 25 1211.2AGTR1, AGT, ACE2, ACE, IL6
43indomethacin46 30 62 1211.2AGTR2, IL6, TGFB1, TNF, AGT
44creatinine468.2AGTR1, AGTR2, AGT, ACE, TGFB1, IL6
45sb 20358046 629.1IL6, TNF, TGFB1, AGT, AGTR1
46actinomycin d468.1TNF, TGFB1, IL6, AGT, AGTR1
47cycloheximide468.0AGTR1, AGTR2, IL6, TGFB1, TNF
48cyclosporin a46 30 629.8TGFB1, AGTR1, AGT, TNF, IL6, AGTR2
49dexamethasone46 52 30 1210.7AGT, IL6, TGFB1, TNF, AGTR1
50nitric oxide46 25 129.3TNF, IL6, AGTR2, AGTR1, AGT, ACE

GO Terms for genes affiliated with Posterior Urethral Valves

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Sources:
17Gene Ontology
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Cellular components related to Posterior Urethral Valves according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.6ACE2, TGFB1, TNF
2external side of plasma membraneGO:0098978.5IL6, ACE, TNF
3extracellular spaceGO:0056157.2TNF, TGFB1, ACE2, ACE, IL6, AGT
4plasma membraneGO:0058867.1TNF, TGFB1, ACE2, ACE, AGTR2, AGTR1
5extracellular regionGO:0055766.9AGT, TNF, TGFB1, ACE2, ACE, IL6

Biological processes related to Posterior Urethral Valves according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idNameGO IDScoreTop Affiliating Genes
1cell growth involved in cardiac muscle cell developmentGO:06104910.2AGTR2, AGT
2negative regulation of neurotrophin TRK receptor signaling pathwayGO:05138710.1AGT, AGTR2
3cellular sodium ion homeostasisGO:00688310.1AGTR2, AGT
4positive regulation of NAD(P)H oxidase activityGO:03386410.1AGT, AGTR1
5angiotensin-activated signaling pathwayGO:03816610.1AGTR1, AGTR2
6regulation of blood vessel size by renin-angiotensinGO:00203410.1AGT, AGTR1
7regulation of renal sodium excretionGO:03581310.1AGTR1, AGT
8regulation of renal output by angiotensinGO:00201910.1AGT, ACE
9G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:00719910.0AGTR2, AGT
10positive regulation of cholesterol esterificationGO:01087310.0AGT, AGTR1
11angiotensin-mediated drinking behaviorGO:00305110.0ACE2, AGT
12positive regulation of renal sodium excretionGO:0358159.9AGTR2, AGT
13low-density lipoprotein particle remodelingGO:0343749.9AGT, AGTR1
14mononuclear cell proliferationGO:0329439.9ACE, TGFB1
15positive regulation of superoxide anion generationGO:0329309.9TGFB1, AGT
16angiotensin catabolic process in bloodGO:0020059.9ACE2, ACE
17cellular response to dexamethasone stimulusGO:0715499.9AGTR2, TGFB1
18negative regulation of blood vessel endothelial cell migrationGO:0435379.8AGTR2, TGFB1
19positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGTR1, AGT
20renin-angiotensin regulation of aldosterone productionGO:0020189.8AGTR1, AGT, AGTR2
21nitric oxide mediated signal transductionGO:0072639.8AGTR2, AGT
22blood vessel remodelingGO:0019749.7ACE, AGTR2, AGT
23positive regulation of branching involved in ureteric bud morphogenesisGO:0901909.7AGT, AGTR2, TGFB1
24positive regulation of cellular protein metabolic processGO:0322709.6TGFB1, AGT, AGTR1
25positive regulation of reactive oxygen species metabolic processGO:20003799.6ACE2, AGT, AGTR1
26kidney developmentGO:0018229.6AGTR1, AGT, ACE
27angiotensin maturationGO:0020039.6ACE2, ACE, AGT
28regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.5ACE2, ACE, AGTR1
29regulation of vasodilationGO:0423129.5AGTR1, ACE, ACE2
30receptor biosynthetic processGO:0328009.5TNF, ACE2
31negative regulation of cell growthGO:0303089.5AGT, AGTR2, TGFB1
32regulation of cell proliferationGO:0421279.5AGTR1, AGT, ACE2
33response to salt stressGO:0096519.4TNF, AGT
34epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.4TNF, IL6
35positive regulation of protein complex assemblyGO:0313349.4TGFB1, TNF
36negative regulation of lipid storageGO:0108889.4TNF, IL6
37positive regulation of cytokine secretionGO:0507159.3AGTR2, TNF
38agingGO:0075689.3TGFB1, IL6, AGT
39positive regulation of cytokine productionGO:0018199.2AGT, TNF
40regulation of vasoconstrictionGO:0192299.2AGTR1, AGT, ACE, ACE2
41positive regulation of nitric oxide biosynthetic processGO:0454299.1AGTR2, IL6, TNF
42positive regulation of chemokine productionGO:0327229.1IL6, TNF
43negative regulation of fat cell differentiationGO:0455998.9TNF, TGFB1, IL6
44positive regulation of peptidyl-serine phosphorylationGO:0331388.9TNF, TGFB1, IL6
45positive regulation of protein kinase B signalingGO:0518978.9TNF, TGFB1, IL6
46protein import into nucleus, translocationGO:0000608.8TGFB1, TNF
47positive regulation of NF-kappaB transcription factor activityGO:0510928.6TNF, TGFB1, IL6, AGT
48inflammatory responseGO:0069548.5TNF, TGFB1, IL6, AGTR2
49negative regulation of cell proliferationGO:0082858.5AGT, IL6, TGFB1, TNF
50positive regulation of transcription, DNA-templatedGO:0458938.2AGT, AGTR2, IL6, TGFB1, TNF

Molecular functions related to Posterior Urethral Valves according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1angiotensin type II receptor activityGO:0049459.9AGTR1, AGTR2
2bradykinin receptor bindingGO:0317119.8AGTR1, ACE
3peptidyl-dipeptidase activityGO:0082419.7ACE, ACE2
4carboxypeptidase activityGO:0041809.6ACE, ACE2
5peptide hormone bindingGO:0170469.5AGTR2, ACE2
6metallopeptidase activityGO:0082379.5ACE, ACE2
7endopeptidase activityGO:0041759.2ACE, ACE2
8growth factor activityGO:0080839.1TGFB1, IL6, AGT
9protein bindingGO:0055156.9TNF, TGFB1, ACE, IL6, AGTR2, AGT

Products for genes affiliated with Posterior Urethral Valves

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  • Antibodies
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Sources for Posterior Urethral Valves

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet