MCID: PST041
MIFTS: 51

Posterior Urethral Valves

Categories: Rare diseases, Nephrological diseases, Fetal diseases

Aliases & Classifications for Posterior Urethral Valves

MalaCards integrated aliases for Posterior Urethral Valves:

Name: Posterior Urethral Valves 49
Congenital Posterior Urethral Valves 69
Posterior Urethral Valve 55
Puv 55

Characteristics:

Orphanet epidemiological data:

55
posterior urethral valve
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Australia); Age of onset: Antenatal,Neonatal; Age of death: early childhood;

Classifications:



External Ids:

Orphanet 55 ORPHA93110
UMLS via Orphanet 70 C0238506 C0542520
ICD10 via Orphanet 33 Q64.2
ICD10 32 Q64.2
UMLS 69 C0238506

Summaries for Posterior Urethral Valves

MalaCards based summary : Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to vesicoureteral reflux 1 and renal dysplasia. An important gene associated with Posterior Urethral Valves is DSTYK (Dual Serine/Threonine And Tyrosine Protein Kinase), and among its related pathways/superpathways are TGF-Beta Pathway and p70S6K Signaling. The drugs Pancuronium and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and prostate, and related phenotypes are Decreased substrate adherent cell growth and growth/size/body region

Wikipedia : 72 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

Related Diseases for Posterior Urethral Valves

Diseases in the Anterior Urethral Valve family:

Posterior Urethral Valves

Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 vesicoureteral reflux 1 30.6 AGT AGTR1 AGTR2
2 renal dysplasia 30.4 ACE AGT AGTR1
3 anuria 29.9 ACE AGT AGTR1
4 chronic kidney failure 29.8 ACE AGT AGTR1 IL6
5 prostatitis 29.6 IL6 TGFB1 TNF
6 pyelonephritis 29.4 ACE IL6 TNF
7 end stage renal failure 28.2 ACE AGT AGTR1 IL6 TGFB1 TNF
8 congenital anomalies of kidney and urinary tract 1 11.3
9 urethritis 11.2
10 congenital anomalies of kidney and urinary tract 2 11.2
11 pediatric hypertension 10.4 ACE AGT
12 renal artery disease 10.3 ACE AGTR1
13 prune belly syndrome 10.3
14 diabetic foot ulcers 10.3 IL6 TGFB1
15 angina pectoris 10.3 ACE IL6
16 hypertensive nephropathy 10.3 ACE AGTR1
17 meningococcal infection 10.2 AGT AGTR1
18 down syndrome 10.2
19 neurogenic hypertension 10.2 ACE2 AGTR1
20 nephrosclerosis 10.1 ACE AGTR1 TGFB1
21 aortic coarctation 10.1 ACE AGT AGTR1
22 diastolic heart failure 10.1 ACE AGT AGTR1
23 malignant hypertension 10.1 ACE AGT AGTR1
24 aging 10.1
25 urethral stricture 10.1
26 oligohydramnios 10.1 ACE AGT AGTR1
27 renal tubular dysgenesis 10.1 ACE AGT AGTR1
28 ischemic optic neuropathy 10.1 ACE AGT AGTR1
29 hypertensive heart disease 10.1 ACE AGT AGTR1
30 mitral valve disease 10.1 ACE AGT AGTR1
31 malignant essential hypertension 10.1 ACE AGTR2
32 familial vesicoureteral reflux 10.1 ACE AGTR2 TGFB1
33 anterior urethral valve 10.1
34 orchitis 10.1
35 ureterocele 10.1
36 urinary tract obstruction 10.1
37 kidney disease 10.1
38 anus, imperforate 10.1
39 epididymo-orchitis 10.1
40 subacute cutaneous lupus erythematosus 10.1 ACE TNF
41 skin sarcoidosis 10.0 ACE TNF
42 granulomatous dermatitis 10.0 ACE TNF
43 beryllium disease 10.0 TGFB1 TNF
44 atrial fibrillation 10.0 ACE AGT AGTR1
45 coronary artery anomaly 10.0 ACE AGTR1 IL6
46 renal tubular acidosis, distal 10.0
47 bladder neck obstruction 10.0
48 renal tubular acidosis 10.0
49 hypospadias 10.0
50 urethral diverticulum 10.0

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to Posterior Urethral Valves

Symptoms & Phenotypes for Posterior Urethral Valves

GenomeRNAi Phenotypes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 8.8 DSTYK AGTR1 AGTR2

MGI Mouse Phenotypes related to Posterior Urethral Valves:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.13 TBX18 TGFB1 TNF AGT SLC3A1 AGTR1
2 cardiovascular system MP:0005385 10.11 TGFB1 TNF TBX18 AGT AGTR1 ACE
3 adipose tissue MP:0005375 10.08 TGFB1 TNF AGT SLC3A1 AGTR1 ACE
4 homeostasis/metabolism MP:0005376 10.06 TGFB1 TNF IL6 AGT SLC3A1 AGTR1
5 immune system MP:0005387 9.97 TGFB1 TNF IL6 AGT SLC3A1 AGTR1
6 mortality/aging MP:0010768 9.96 TBX18 TGFB1 TNF IL6 AGT SLC3A1
7 integument MP:0010771 9.8 TBX18 TGFB1 TNF IL6 AGTR2 ACE2
8 muscle MP:0005369 9.7 TBX18 TGFB1 TNF IL6 AGT AGTR2
9 neoplasm MP:0002006 9.35 TGFB1 TNF IL6 ACE AGTR2
10 renal/urinary system MP:0005367 9.28 TGFB1 TBX18 AGT SLC3A1 AGTR1 ACE

Drugs & Therapeutics for Posterior Urethral Valves

Drugs for Posterior Urethral Valves (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancuronium Approved Phase 2 15500-66-0 441289 27350
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 2 437-38-7 3345
3 Anesthetics Phase 2
4 Anti-Bacterial Agents
5 Anti-Infective Agents
6 Antibiotics, Antitubercular
7 Antitubercular Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract Obstructions Not yet recruiting NCT01552824 Phase 2
2 Validation of a Fetal Urine Peptidome-based Classifier to Predict Post-natal Renal Function in Posterior Urethral Valves Recruiting NCT03116217
3 Standardized Prenatal Clinical Care for LUTO Recruiting NCT02315521
4 CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral Valves Active, not recruiting NCT01537601
5 Fetal Cystoscopy for Lower Urinary Tract Obstruction Terminated NCT02446184

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

Anatomical Context for Posterior Urethral Valves

MalaCards organs/tissues related to Posterior Urethral Valves:

38
Lung, Kidney, Prostate, Testes, Spinal Cord

Publications for Posterior Urethral Valves

Articles related to Posterior Urethral Valves:

(show top 50) (show all 555)
# Title Authors Year
1
Caring for infants with posterior urethral valves: A qualitative study of parents' experiences. ( 29110519 )
2017
2
Can quantity of amniotic fluid reliably predict postnatal renal function in boys with posterior urethral valves: a decision curve analysis. ( 28753736 )
2017
3
Aggressive diagnosis and treatment for posterior urethral valve as an etiology for vesicoureteral reflux or urge incontinence in children. ( 28612060 )
2017
4
Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient determination. ( 28453880 )
2017
5
Comment on "Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient determination". ( 28777461 )
2017
6
Posterior urethral valves: Impact of low birth weight and preterm delivery on the final renal outcome. ( 29071146 )
2017
7
Prediction of need for intervention in posterior urethral valves: Use of urine osmolality. ( 29223674 )
2017
8
Current strategies to predict and manage sequelae of posterior urethral valves in children. ( 29159472 )
2017
9
Impact of Adjuvant Urinary Diversion versus Valve Ablation Alone on Progression from Chronic to End Stage Renal Disease in Posterior Urethral Valves: A Single Institution 15-Year Time-to-Event Analysis. ( 29061539 )
2017
10
Genetic Basis of Posterior Urethral Valves Inheritance. ( 27261184 )
2016
11
Outcome of Antenatally Presenting Posterior Urethral Valves (PUV) in Children. ( 28031548 )
2016
12
Posterior urethral valves and vesicoureteral reflux: can prenatal ultrasonography distinguish between these two conditions in male fetuses? ( 27374758 )
2016
13
Posterior urethral valves: are neonatal imaging findings predictive of renal function during early childhood? ( 27401742 )
2016
14
Predicting risk of chronic kidney disease in infants and young children with posterior urethral valves at time of diagnosis: Objective analysis of initial ultrasound kidney characteristics and validation of parenchyma area as forecasters of renal reserve. ( 27017936 )
2016
15
Rare copy number variants implicated in posterior urethral valves. ( 26663319 )
2016
16
Challenges in Predicting Renal Outcomes in Boys with Posterior Urethral Valves. ( 27311411 )
2016
17
Re: Combined Creatinine Velocity and Nadir Creatinine: A Reliable Predictor of Renal Outcome in Neonatally Diagnosed Posterior Urethral Valves. ( 26887751 )
2016
18
Controlled Outcomes for Achievement of Urinary Continence among Boys Treated for Posterior Urethral Valves. ( 26964916 )
2016
19
Posterior urethral valves: how the study of fetal micturition can help to reach the diagnosis? ( 27351949 )
2016
20
Vesicostomy and Colostomy in a Premature Neonate With Posterior Urethral Valves, Bilateral Dysplastic Kidneys, and High Imperforate Anus: The Challenge of Stoma Placement. ( 27015939 )
2016
21
Posterior urethral valves (PUV) in pediatric practice - Promoting methods to understand how to diagnose and incise (PUV). ( 26921022 )
2016
22
DNA copy number variants: A potentially useful predictor of early onset renal failure in boys with posterior urethral valves. ( 27160979 )
2016
23
Re: Nadir Creatinine in Posterior Urethral Valves: How High is Low Enough? ( 26853033 )
2016
24
Presentation, management, and outcome of posterior urethral valves in a Nigerian tertiary hospital. ( 25659544 )
2015
25
Antenatal Determinants of Long-Term Kidney Outcome in Boys with Posterior Urethral Valves. ( 26375276 )
2015
26
Combined creatinine velocity and nadir creatinine: A reliable predictor of renal outcome in neonatally diagnosed posterior urethral valves. ( 26062970 )
2015
27
Study of prognostic significance of antenatal ultrasonography and renin angiotensin system activation in predicting disease severity in posterior urethral valves. ( 25829668 )
2015
28
Split-cuff nipple technique of ureteral reimplantation in children with thick-walled bladders due to posterior urethral valves. ( 25444631 )
2015
29
Laser Ablation of Posterior Urethral Valves by Fetal Cystoscopy. ( 25614247 )
2015
30
Re: Tran et al.: anterior urethral valve associated with posterior urethral valves: report of 2 cases and review of the literature (Urology 2014;84:469-471). ( 25733298 )
2015
31
Concomitant anterior and posterior urethral valves in pediatrics: A single center experience over 12a88years and long-term follow up after endoscopic treatment. ( 25689730 )
2015
32
Posterior urethral valve with unilateral vesicoureteral reflux and patent urachus: A rare combination of urinary tract anomaliess. ( 25836363 )
2015
33
Late diagnosis of posterior urethral valves. ( 26112258 )
2015
34
Posterior urethral valves: Risk factors for progression to renal failure. ( 26705688 )
2015
35
Nadir creatinine in posterior urethral valves: How high is low enough? ( 26292912 )
2015
36
Posterior urethral valves: Metabolic consequences in a cohort of patients. ( 26096436 )
2015
37
Concomitant Anterior and Posterior Urethral Valves: A Comprehensive Review of Literature. ( 25863834 )
2015
38
Posterior Urethral Valves in Children: Pattern of Presentation and Outcome of Initial Treatment in Ile-Ife, Nigeria. ( 26425072 )
2015
39
Posterior urethral polyp with type I posterior urethral valves: a rare association in a neonate. ( 24767515 )
2014
40
Epidemiology and demography of recently diagnosed cases of posterior urethral valves. ( 25198372 )
2014
41
Urinary tract tuberculosis in a child with late presentation posterior urethral valves. ( 24529021 )
2014
42
Neonatal presentation of posterior urethral valves and tethered spinal cord. ( 25073498 )
2014
43
Re: long-term bladder function, fertility and sexual function in patients with posterior urethral valves treated in infancy. ( 24331507 )
2014
44
The management of vesicoureteral reflux in the setting of posterior urethral valve with emphasis on bladder function and renal outcome: a single center cohort study. ( 24149109 )
2014
45
Population-specific serum creatinine centiles in neonates with posterior urethral valves already predict long-term renal outcome. ( 25000449 )
2014
46
Urological fistulas after fetal cystoscopic laser ablation of posterior urethral valves - surgical technical aspects. ( 24817027 )
2014
47
Late presentation of posterior urethral valves. ( 24906275 )
2014
48
Anterior urethral valve associated with posterior urethral valves: report of 2 cases and review of the literature. ( 24958476 )
2014
49
Utilization of computer enhanced visual learning (CEVL) method improves endoscopic diagnosis of posterior urethral valves (PUV). ( 22981142 )
2013
50
Re: delayed presentation of posterior urethral valves in discordant twins. ( 23394670 )
2013

Variations for Posterior Urethral Valves

Expression for Posterior Urethral Valves

Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for Posterior Urethral Valves

Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 AGT AGTR1 AGTR2 IL6 TGFB1 TNF
2
Show member pathways
12.68 ACE AGT AGTR1 AGTR2 IL6 TGFB1
3
Show member pathways
12.67 AGTR1 IL6 TGFB1 TNF
4
Show member pathways
12.3 ACE IL6 TGFB1 TNF
5
Show member pathways
12.07 ACE ACE2 AGT
6 12.06 IL6 TGFB1 TNF
7 12.01 IL6 TGFB1 TNF
8
Show member pathways
11.98 AGT TGFB1 TNF
9
Show member pathways
11.91 ACE IL6 TGFB1 TNF
10 11.84 IL6 TGFB1 TNF
11 11.8 IL6 TGFB1 TNF
12
Show member pathways
11.74 IL6 TGFB1 TNF
13 11.69 IL6 TGFB1 TNF
14 11.65 IL6 TGFB1 TNF
15 11.58 AGT IL6 TGFB1 TNF
16 11.54 IL6 TGFB1 TNF
17 11.47 IL6 TGFB1 TNF
18 11.45 ACE AGT AGTR1
19 11.41 IL6 TGFB1 TNF
20 11.27 IL6 TGFB1 TNF
21 11.25 AGTR1 IL6 TGFB1 TNF
22
Show member pathways
11 ACE ACE2 AGT AGTR1 AGTR2 TGFB1
23 10.97 ACE ACE2
24 10.94 IL6 TNF
25 10.91 IL6 TGFB1 TNF
26 10.87 IL6 TNF
27 10.72 TGFB1 TNF
28 10.64 IL6 TGFB1

GO Terms for Posterior Urethral Valves

Cellular components related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ACE ACE2 AGT IL6 TGFB1 TNF
2 extracellular region GO:0005576 9.17 ACE ACE2 AGT AGTR2 IL6 TGFB1

Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.99 AGTR2 IL6 TGFB1 TNF
2 negative regulation of cell growth GO:0030308 9.86 AGT AGTR2 TGFB1
3 kidney development GO:0001822 9.85 ACE AGT AGTR1
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 AGT IL6 TGFB1
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.82 IL6 TGFB1 TNF
6 regulation of inflammatory response GO:0050727 9.81 ACE2 AGTR1 TNF
7 regulation of blood pressure GO:0008217 9.8 ACE AGT AGTR2
8 negative regulation of fat cell differentiation GO:0045599 9.79 IL6 TGFB1 TNF
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 AGT AGTR2 TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.78 AGT IL6 TGFB1 TNF
11 regulation of cell proliferation GO:0042127 9.77 ACE2 AGT AGTR1 TGFB1 TNF
12 positive regulation of cytokine secretion GO:0050715 9.72 AGTR2 TNF
13 protein import into nucleus, translocation GO:0000060 9.72 TGFB1 TNF
14 positive regulation of cytokine production GO:0001819 9.72 AGT TNF
15 positive regulation of extrinsic apoptotic signaling pathway GO:2001238 9.71 AGT AGTR2
16 positive regulation of blood vessel diameter GO:0097755 9.71 AGT AGTR2
17 positive regulation of protein complex assembly GO:0031334 9.71 TGFB1 TNF
18 negative regulation of myoblast differentiation GO:0045662 9.71 TGFB1 TNF
19 vasodilation GO:0042311 9.71 AGT AGTR2
20 blood vessel remodeling GO:0001974 9.71 ACE AGT AGTR2
21 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.7 AGT TNF
22 positive regulation of chemokine production GO:0032722 9.7 IL6 TNF
23 nitric oxide mediated signal transduction GO:0007263 9.7 AGT AGTR2
24 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.69 AGT AGTR1
25 cell growth involved in cardiac muscle cell development GO:0061049 9.69 AGT AGTR2
26 positive regulation of superoxide anion generation GO:0032930 9.68 AGT TGFB1
27 low-density lipoprotein particle remodeling GO:0034374 9.68 AGT AGTR1
28 positive regulation of renal sodium excretion GO:0035815 9.68 AGT AGTR2
29 cellular sodium ion homeostasis GO:0006883 9.67 AGT AGTR2
30 neutrophil mediated immunity GO:0002446 9.67 ACE IL6
31 negative regulation of lipid storage GO:0010888 9.66 IL6 TNF
32 positive regulation of cholesterol esterification GO:0010873 9.66 AGT AGTR1
33 angiotensin-activated signaling pathway GO:0038166 9.65 AGTR1 AGTR2
34 regulation of protein import into nucleus GO:0042306 9.64 AGTR2 TGFB1
35 positive regulation of reactive oxygen species metabolic process GO:2000379 9.63 ACE2 AGT AGTR1
36 positive regulation of NAD(P)H oxidase activity GO:0033864 9.62 AGT AGTR1
37 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051387 9.62 AGT AGTR2
38 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.61 AGT AGTR2 TGFB1
39 angiotensin catabolic process in blood GO:0002005 9.6 ACE ACE2
40 positive regulation of gap junction assembly GO:1903598 9.59 ACE2 AGT
41 angiotensin-mediated drinking behavior GO:0003051 9.58 ACE2 AGT
42 receptor biosynthetic process GO:0032800 9.58 ACE2 TNF
43 positive regulation of cellular protein metabolic process GO:0032270 9.58 AGT AGTR1 TGFB1
44 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.57 AGT AGTR1
45 regulation of renal sodium excretion GO:0035813 9.56 AGT AGTR1
46 positive regulation of mononuclear cell migration GO:0071677 9.55 TGFB1 TNF
47 regulation of renal output by angiotensin GO:0002019 9.52 ACE AGT
48 mononuclear cell proliferation GO:0032943 9.51 ACE TGFB1
49 angiotensin maturation GO:0002003 9.5 ACE ACE2 AGT
50 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007199 9.49 AGT AGTR2

Molecular functions related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.67 AGTR1 SLC3A1 TBX18 TGFB1
2 growth factor activity GO:0008083 9.5 AGT IL6 TGFB1
3 carboxypeptidase activity GO:0004180 9.26 ACE ACE2
4 peptidyl-dipeptidase activity GO:0008241 9.16 ACE ACE2
5 angiotensin type II receptor activity GO:0004945 8.96 AGTR1 AGTR2
6 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Posterior Urethral Valves

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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