MCID: PST041
MIFTS: 46

Posterior Urethral Valves malady

Categories: Rare diseases, Nephrological diseases, Fetal diseases

Aliases & Classifications for Posterior Urethral Valves

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Sources:
30ICD10 via Orphanet, 47NIH Rare Diseases, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Posterior Urethral Valves:

Name: Posterior Urethral Valves 47
Congenital Posterior Urethral Valves 67
 
Posterior Urethral Valve 53
Puv 53

Characteristics:

Orphanet epidemiological data:

53
posterior urethral valve:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Australia); Age of onset: Antenatal,Neonatal; Age of death: early childhood

Classifications:



External Ids:

Orphanet53 ORPHA93110
UMLS via Orphanet68 C0238506, C0542520
ICD10 via Orphanet30 Q64.2

Summaries for Posterior Urethral Valves

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Wikipedia:70 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards based summary: Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to congenital anomalies of kidney and urinary tract and urinary tract obstruction. An important gene associated with Posterior Urethral Valves is DSTYK (Dual Serine/Threonine And Tyrosine Protein Kinase), and among its related pathways are IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include lung, kidney and prostate, and related mouse phenotypes are neoplasm and muscle.

Related Diseases for Posterior Urethral Valves

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Diseases in the Anterior Urethral Valve family:

posterior urethral valves

Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1congenital anomalies of kidney and urinary tract32.7DSTYK, TBX18
2urinary tract obstruction29.9AGTR1, AGTR2, TGFB1
3sinusitis29.4ACE, TGFB1, TNF
4pyelonephritis28.8ACE, AGT, IL6, TNF
5urethritis11.1
6pelviureteric junction obstruction11.1
7pediatric ulcerative colitis10.5ACE, AGT
8familial hypopituitarism10.4AGT, AGTR1
9vibrio vulnificus infection10.3IL6, TGFB1
10vesicoureteral reflux10.3
11chronic diarrhea due to guanylate cyclase 2c overactivity10.3ACE, IL6
12marchiafava bignami disease10.3ACE, IL6
13podder-tolmie syndrome10.3AGT, AGTR1
14broad ligament malignant neoplasm10.2ACE, AGTR1
15hypopigmentation of eyelid10.2ACE, AGTR1, TGFB1
16prune belly syndrome10.2
17ovarian cancer10.2ACE, AGT, AGTR1
18casr-related disorders10.2ACE, AGT, AGTR1
19antiphospholipid syndrome10.2ACE, AGT, AGTR1
20chylocele of tunica vaginalis10.2ACE, AGT, AGTR1
21aortic valves stenosis of the child10.2ACE, AGT, AGTR1
22benign hypertensive renal disease10.2ACE, AGT, AGTR1
23renal tubular dysgenesis10.2ACE, AGT, AGTR1
24joint disorders10.2ACE, AGT, AGTR1
25collecting duct carcinoma10.2ACE, AGT, AGTR1
26herpetic gastritis10.2ACE, AGT, AGTR1
27down syndrome10.1
28congenital methemoglobinemia10.1AGTR1, IL6, TGFB1
29voyeurism10.1ACE, AGTR2
30uveoparotid fever10.1ACE, TNF
31acneiform dermatitis10.1ACE, TNF
32parsonage turner syndrome10.1TGFB1, TNF
33myopathy-growth delay-intellectual disability-hypospadias syndrome10.1TGFB1, TNF
34fatal infantile hypertrophic cardiomyopathy due to mitochondrial complex i deficiency10.1ACE, AGTR2, TGFB1
35pneumoconiosis due to talc10.1TGFB1, TNF
36urethral stricture10.1
37renal dysplasia10.1
38addison's disease10.0TGFB1, TNF
39panner disease10.0IL6, TNF
40aortic arch interruption10.0IL6, TNF
41imperforate anus10.0
42orchitis10.0
43ureterocele10.0
44epididymo-orchitis10.0
45anterior urethral valve10.0
46cutaneous leishmaniasis10.0IL6, TNF
47maligant granulosa cell tumor of ovary10.0IL6, TNF
48hemometra10.0IL6, TNF
49tricho odonto onycho dermal syndrome10.0IL6, TNF
50epstein-barr virus hepatitis9.9IL6, TNF

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Symptoms for Posterior Urethral Valves

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Drugs & Therapeutics for Posterior Urethral Valves

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Drugs for Posterior Urethral Valves (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Fentanylapproved, illicit, investigational, vet_approvedPhase 2773437-38-73345
Synonyms:
1-Phenethyl-4-(N-phenylpropionamido)piperidine
1-Phenethyl-4-N-propionylanilinopiperidine
1-phenethyl-4-N-propionylanilinopiperidine
437-38-7
5-22-08-00049 (Beilstein Handbook Reference)
80832-90-2
990-73-8 (citrate)
AC1L1FQ2
Actiq
BIDD:GT0555
BRN 0494484
CHEBI:119915
CHEMBL596
CID3345
D00320
DB00813
Duragesic
Duragesic (TN)
Duragesic-100
Duragesic-12
Duragesic-25
Duragesic-50
Duragesic-75
Durogesic
EINECS 207-113-6
Fentanest
Fentanil
Fentanil [DCIT]
Fentanila
Fentanila [INN-Spanish]
Fentanilo
Fentanyl
Fentanyl (JAN/USAN/INN)
Fentanyl CII
Fentanyl [INN:BAN]
Fentanyl citrate
Fentanyl-100
Fentanyl-12
Fentanyl-25
 
Fentanyl-50
Fentanyl-75
Fentanylum
Fentanylum [INN-Latin]
HSDB 3329
IONSYS
JNS020QD
L001275
LS-124439
Matrifen
MolPort-003-847-369
N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-Phenethyl-4-piperidyl)propionanilide
N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidyl)propionanilide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide
N-Phenethyl-4-(N-propionylanilino)piperidine
N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenethyl-4-(N-propionylanilino)piperidine
N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
NCGC00168252-01
Nasalfent
Oprea1_152073
Oprea1_207148
PDSP1_000860
PDSP2_000846
Pentanyl
Phentanyl
Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)
R 4263
Rapinyl
Sentonil
Sublimase
Sublimaze
UNII-UF599785JZ
fentanyl
2
PancuroniumapprovedPhase 2315500-66-027350, 441289
Synonyms:
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(1-methylpiperidinium-1-yl)androstane dibromide
1,1'-(3,17-Bis(acetyloxy)androstane-2,16-diyl)bis(1-methylpiperidinium) dibromide
1,1'-(3alpha,17beta-Bis(acetyloxy)-5alpha-androstane-2beta,16beta-diyl)bis(1-methylpiperidinium) dibromide
1,1'-(3alpha,17beta-Dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methylpiperidinium) dibromide diacetate
1,1'-([2beta,3alpha,5alpha,16beta,17beta]-3,17-Bis[acetyloxy]androstane-2,16-diyl)bis(1-methylpiperidinium) dibromide
1,1'-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide
15500-66-0
2beta,16beta-Dipiperidino-5alpha-androstane-3alpha,17beta-diol diacetate dimethobromide
2beta,16beta-Dipiperidino-5alpha-androstane-3alpha,17beta-dioldiacetatedimethobromide
3-alpha,17-beta-Diacetoxy-2-beta,16-beta-dipiperidino-5-alpha-androstane dimethobromide
3alpha,17beta-Diacetoxy-2beta,16beta-dipiperidino-5alpha-androstane dimethobromide
3alpha,17beta-diacetoxy-2beta,16beta-bis(1-methylpiperidinium-1-yl)-5alpha-androstane
3alpha,17beta-diacetoxy-2beta,16beta-bis(1-methylpiperidinium-1-yl)-5alpha-androstane dibromide
5alpha-Androstan-3alpha,17beta-diol, 2beta,16beta-dipipecolinio-, dibromide, diacetate
AB00384328
AC1L1D1A
AC1L9AWJ
Ambap15500-66-0
BPBio1_001372
BSPBio_001247
Bromure de pancuronium
Bromure de pancuronium [INN-French]
Bromure de pancuronium [inn-french]
Bromuro de pancuronio
Bromuro de pancuronio [INN-Spanish]
Bromuro de pancuronio [inn-spanish]
C07551
C35H60N2O4
CHEBI:7907
CHEBI:7908
CHEMBL1200757
CHEMBL185073
CID27350
CID441289
D00492
DB01337
EINECS 239-532-5
EU-0100887
HMS1571O09
HMS2089M07
 
HSDB 3244
LS-116480
Lopac0_000887
Mioblock
MolPort-003-938-961
NA 97
NCGC00023037-03
NCGC00023037-04
NCGC00023037-05
NSC 293162
NSC293162
ORG NA 97
ORG-NA 97
P 1918
P1918_SIGMA
PANCURONIUM BROMIDE
Pancuronii bromidum
Pancuronii bromidum [INN-Latin]
Pancuronium
Pancuronium bromide
Pancuronium bromide (JP15/USAN/INN)
Pancuronium bromide [USAN:BAN:INN:JAN]
Pancuronium dibromide
Pavulon
Pavulon (TN)
Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl)-, dibromide
Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl-, dibromide
Piperidinium, 1,1'-(2-beta,16-beta-(3-alpha,17-beta-dihydroxy-5-alpha-androstanylene))bis(1-methyl-, dibromide, diacetate
Piperidinium, 1,1'-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methyl-, dibromide, diacetate
Piperidinium, 1,1'-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methyl-, dibromide, diacetate (8CI)
Piperidinium, 1,1'-[(2.beta.,3.alpha.,5.alpha.,16.beta.,17.beta.)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide
Poncuronium bromide
Prestwick0_001034
Prestwick1_001034
Prestwick2_001034
Prestwick3_001034
S2497_Selleck
SPBio_003098
UNII-U9LY9Y75X2
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate dibromide
pancuronium
3AnestheticsPhase 2, Phase 19001
4Antitubercular Agents1272
5Anti-Infective Agents21402
6Anti-Bacterial Agents10884
7Antibiotics, Antitubercular6972

Interventional clinical trials:

idNameStatusNCT IDPhase
1Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract ObstructionsNot yet recruitingNCT01552824Phase 2
2Fetal Cystoscopy for Lower Urinary Tract ObstructionRecruitingNCT02446184Phase 1
3CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral ValvesRecruitingNCT01537601
4Standardized Prenatal Clinical Care for LUTORecruitingNCT02315521

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

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Anatomical Context for Posterior Urethral Valves

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MalaCards organs/tissues related to Posterior Urethral Valves:

35
Lung, Kidney, Prostate, Testes, Spinal cord

Animal Models for Posterior Urethral Valves or affiliated genes

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MGI Mouse Phenotypes related to Posterior Urethral Valves:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ACE, AGTR2, IL6, TGFB1, TNF
2MP:00053697.8ACE2, AGT, AGTR2, IL6, TBX18, TGFB1
3MP:00053877.5ACE, ACE2, AGT, AGTR1, IL6, SLC3A1
4MP:00053757.5ACE, AGT, AGTR1, AGTR2, IL6, SLC3A1
5MP:00053857.2ACE, ACE2, AGT, AGTR1, AGTR2, IL6
6MP:00053766.9ACE, ACE2, AGT, AGTR1, AGTR2, IL6
7MP:00053786.6ACE, ACE2, AGT, AGTR1, AGTR2, IL6
8MP:00053676.6ACE, ACE2, AGT, AGTR1, AGTR2, IL6
9MP:00107686.6ACE, ACE2, AGT, AGTR1, AGTR2, IL6

Publications for Posterior Urethral Valves

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Articles related to Posterior Urethral Valves:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Outcome of Antenatally Presenting Posterior Urethral Valves (PUV) in Children. (28031548)
2016
2
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
3
Posterior urethral valves: Persistent renin angiotensin system activation after valve ablation and role of pre-emptive therapy with angiotensin converting enzyme-inhibitors on renal recovery. (23798811)
2013
4
Efficacy of bladder neck incision on urodynamic abnormalities in patients with posterior urethral valves. (23417544)
2013
5
A case of Down syndrome with a posterior urethral valve. (23326062)
2012
6
Posterior urethral valve: delayed presentation in adolescence. (23094222)
2012
7
Posterior urethral valves: long-term outcome. (21748651)
2011
8
Timing of posterior urethral valve diagnosis and its impact on clinical outcome. (20829118)
2011
9
A rare cause of ascites in a newborn: posterior urethral valve. (20158664)
2010
10
Posterior urethral valves: a single center experience over 7 years. (19184051)
2009
11
Outcome of endoscopic fulguration of posterior urethral valves in children. (19623154)
2009
12
Vesicoureteral reflux in conjunction with posterior urethral valves. (19683736)
2009
13
Re: The effects of bladder neck incision on urodynamic abnormalities of children with posterior urethral valves. A. M. Kajbafzadeh, S. Payabvash and G. Karimian. J Urol 2007; 178: 2142-2149. (18436260)
2008
14
Posterior urethral valves in three siblings: a case report and review of the literature. (18240166)
2008
15
A review of urodynamic evaluation in children and its role in the management of boys with posterior urethral valves. (19718301)
2007
16
Vesicostomy vs primary ablation for posterior urethral valves: always a difference in outcome? (18947754)
2007
17
The impact of late presentation of posterior urethral valves on bladder and renal function. (16600793)
2006
18
Re: The impact of late presentation of posterior urethral valves on bladder and renal function. O. Ziylan, T. Oktar, H. Ander, E. Korgali, H. Rodoplu and T. Kocak, J Urol, 175: 1894-1897, 2006. (17085214)
2006
19
Posterior urethral valves in patients with Down syndrome. (16186689)
2005
20
Initial and long-term management of posterior urethral valves. (15558286)
2004
21
Posterior urethral valves: prognostic factors. (12699486)
2003
22
Incidental adult posterior urethral valve without clinical features. (15072500)
2003
23
Posterior urethral valves and mirror image anomalies in monozygotic twins. (12210353)
2002
24
Prospective analysis of renal function and somatic growth in neonatal posterior urethral valves. (12369006)
2002
25
Posterior urethral valves causing urinomas: two case reports. (11966598)
2002
26
Posterior urethral valves. (11294257)
2001
27
Does neonatal pyeloureterostomy worsen bladder function in children with posterior urethral valves? (10958734)
2000
28
Does treatment of bladder dysfunction prior to renal transplant improve outcome in patients with posterior urethral valves? (11272604)
2000
29
Posterior urethral valves after infancy-urodynamic consequences. (9716680)
1998
30
Posterior urethral valves presenting as post-ejaculatory dysuria in a 29-year-old physician. (9628623)
1998
31
The long-term outcome of posterior urethral valves treated with primary valve ablation and observation. (8627873)
1996
32
Posterior urethral valves: a report of five cases. (7634189)
1995
33
Mercapto-acetyltriglycine (MAG 3) renography and indirect radionuclide cystography in posterior urethral valves. (7827852)
1994
34
Type III posterior urethral valves: presentation and management. (8120770)
1994
35
Re: Delayed presentation of posterior urethral valves. S. A. Merchant et al. Br. J. Urol., 69, 318-319, 1992. (10071574)
1993
36
Posterior urethral valves. Does prenatal diagnosis influence prognosis? (8080495)
1993
37
Re: Renal transplantation in children with posterior urethral valves. (1294129)
1992
38
Influence of initial therapy on progression of renal failure and body growth in children with posterior urethral valves. (1640516)
1992
39
Laser treatment of posterior urethral valves in neonates. (1581816)
1992
40
Alternatives in the management of posterior urethral valves. (2186539)
1990
41
99mTc DTPA scintigraphy compared with intravenous urography in the follow-up of posterior urethral valves. (3322473)
1987
42
An antegrade technique for ablation of posterior urethral valves. (6492291)
1984
43
Posterior urethral valves causing urinary retention in an infant with duplication of the urethra. (6737596)
1984
44
Congenital posterior urethral valves: problems of management in countries with limited facilities. (6200066)
1983
45
The variable effect of posterior urethral valves as illustrated in identical twins. (6685777)
1983
46
Major and minor complications of posterior urethral valves. (7288943)
1981
47
The protean aspects of posterior urethral valves. (7321118)
1981
48
Renal hypoplasia and dysplasia in infants with posterior urethral valves. (7189794)
1980
49
Upper tract management when posterior urethral valve ablation is insufficient. (470011)
1979
50
Obstructive posterior urethral valves: the light at the end of the tunnel. (1113426)
1975

Variations for Posterior Urethral Valves

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Expression for genes affiliated with Posterior Urethral Valves

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Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for genes affiliated with Posterior Urethral Valves

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Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.7IL6, TGFB1
29.6ACE, ACE2
39.4ACE, AGT, AGTR1
49.3TGFB1, TNF
5
Show member pathways
9.3ACE, ACE2, AGT
69.2IL6, TNF
78.9AGT, TGFB1, TNF
88.9IL6, TGFB1, TNF
98.9IL6, TGFB1, TNF
108.9IL6, TGFB1, TNF
11
Show member pathways
8.9IL6, TGFB1, TNF
128.9IL6, TGFB1, TNF
138.9IL6, TGFB1, TNF
148.9IL6, TGFB1, TNF
158.9IL6, TGFB1, TNF
168.9IL6, TGFB1, TNF
178.9IL6, TGFB1, TNF
188.5AGT, IL6, TGFB1, TNF
198.4AGTR1, IL6, TGFB1, TNF
20
Show member pathways
7.9ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
21
Show member pathways
7.9ACE, ACE2, AGT, AGTR1, AGTR2, TGFB1
22
Show member pathways
7.4AGT, AGTR1, AGTR2, IL6, TGFB1, TNF

GO Terms for genes affiliated with Posterior Urethral Valves

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Cellular components related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.6ACE, ACE2, AGT, IL6, TGFB1, TNF
2extracellular regionGO:00055766.7ACE, ACE2, AGT, AGTR2, IL6, TGFB1

Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1regulation of renal output by angiotensinGO:000201910.5ACE, AGT
2mononuclear cell proliferationGO:003294310.5ACE, TGFB1
3positive regulation of cholesterol esterificationGO:001087310.4AGT, AGTR1
4angiotensin catabolic process in bloodGO:000200510.4ACE, ACE2
5angiotensin-mediated drinking behaviorGO:000305110.3ACE2, AGT
6low-density lipoprotein particle remodelingGO:003437410.3AGT, AGTR1
7positive regulation of superoxide anion generationGO:003293010.2AGT, TGFB1
8regulation of renal sodium excretionGO:003581310.2AGT, AGTR1
9G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:000719910.2AGT, AGTR2
10negative regulation of neurotrophin TRK receptor signaling pathwayGO:005138710.2AGT, AGTR2
11positive regulation of macrophage derived foam cell differentiationGO:001074410.2AGT, AGTR1
12neutrophil mediated immunityGO:000244610.2ACE, IL6
13positive regulation of gap junction assemblyGO:190359810.2ACE2, AGT
14positive regulation of NAD(P)H oxidase activityGO:003386410.2AGT, AGTR1
15cellular sodium ion homeostasisGO:000688310.1AGT, AGTR2
16cell growth involved in cardiac muscle cell developmentGO:006104910.1AGT, AGTR2
17angiotensin-activated signaling pathwayGO:003816610.0AGTR1, AGTR2
18positive regulation of mononuclear cell migrationGO:007167710.0TGFB1, TNF
19regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.9ACE, ACE2, AGTR1
20positive regulation of protein complex assemblyGO:00313349.9TGFB1, TNF
21positive regulation of cellular protein metabolic processGO:00322709.9AGT, AGTR1, TGFB1
22regulation of vasodilationGO:00423129.9ACE, ACE2, AGTR1
23nitric oxide mediated signal transductionGO:00072639.9AGT, AGTR2
24positive regulation of chemokine productionGO:00327229.9IL6, TNF
25epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.9IL6, TNF
26receptor biosynthetic processGO:00328009.8ACE2, TNF
27positive regulation of branching involved in ureteric bud morphogenesisGO:00901909.8AGT, AGTR2, TGFB1
28kidney developmentGO:00018229.8ACE, AGT, AGTR1
29renin-angiotensin regulation of aldosterone productionGO:00020189.8AGT, AGTR1, AGTR2
30positive regulation of reactive oxygen species metabolic processGO:20003799.7ACE2, AGT, AGTR1
31negative regulation of lipid storageGO:00108889.7IL6, TNF
32angiotensin maturationGO:00020039.7ACE, ACE2, AGT
33negative regulation of blood vessel endothelial cell migrationGO:00435379.7AGTR2, TGFB1
34positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.7AGT, IL6, TGFB1
35negative regulation of myoblast differentiationGO:00456629.6TGFB1, TNF
36positive regulation of renal sodium excretionGO:00358159.5AGT, AGTR2
37regulation of vasoconstrictionGO:00192299.4ACE, ACE2, AGT, AGTR1
38regulation of blood pressureGO:00082179.4ACE, AGT, AGTR2
39positive regulation of protein kinase B signalingGO:00518979.3IL6, TGFB1, TNF
40blood vessel remodelingGO:00019749.3ACE, AGT, AGTR2
41negative regulation of cell growthGO:00303089.2AGT, AGTR2, TGFB1
42negative regulation of fat cell differentiationGO:00455999.2IL6, TGFB1, TNF
43cellular response to dexamethasone stimulusGO:00715499.0AGTR2, IL6, TGFB1
44positive regulation of peptidyl-serine phosphorylationGO:00331388.9IL6, TGFB1, TNF
45positive regulation of NF-kappaB transcription factor activityGO:00510928.9AGT, IL6, TGFB1, TNF
46inflammatory responseGO:00069548.5AGTR2, IL6, TGFB1, TNF
47positive regulation of nitric oxide biosynthetic processGO:00454298.4AGT, AGTR2, IL6, TNF
48positive regulation of transcription, DNA-templatedGO:00458938.1AGT, AGTR2, IL6, TGFB1, TNF
49regulation of cell proliferationGO:00421277.5ACE2, AGT, AGTR1, IL6, TGFB1, TNF

Molecular functions related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.4ACE, AGTR1
2peptidyl-dipeptidase activityGO:000824110.2ACE, ACE2
3angiotensin type II receptor activityGO:000494510.1AGTR1, AGTR2
4carboxypeptidase activityGO:000418010.0ACE, ACE2
5growth factor activityGO:00080839.5AGT, IL6, TGFB1
6cytokine activityGO:00051259.1IL6, TGFB1, TNF
7protein heterodimerization activityGO:00469828.9AGTR1, SLC3A1, TBX18, TGFB1

Sources for Posterior Urethral Valves

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
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31ICD9CM
32IUPHAR
33KEGG
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40MGI
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45NDF-RT
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66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet