MCID: PST041
MIFTS: 47

Posterior Urethral Valves malady

Categories: Rare diseases, Nephrological diseases, Fetal diseases

Aliases & Classifications for Posterior Urethral Valves

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Sources:
45NIH Rare Diseases, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Posterior Urethral Valves:

Name: Posterior Urethral Valves 45
Congenital Posterior Urethral Valves 65
 
Posterior Urethral Valve 51
Puv 51

Characteristics:

Orphanet epidemiological data:

51
posterior urethral valve:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Antenatal,Neonatal; Age of death: early childhood

Classifications:



External Ids:

Orphanet51 93110
ICD10 via Orphanet28 Q64.2
UMLS via Orphanet66 C0238506, C0542520
ICD1027 Q64.2
UMLS65 C0238506

Summaries for Posterior Urethral Valves

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Wikipedia:68 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards based summary: Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to congenital anomalies of kidney and urinary tract and thyroiditis. An important gene associated with Posterior Urethral Valves is TBX18 (T-Box 18), and among its related pathways are A-beta Pathways: Plaque Formation and APP Metabolism and A-beta Pathways: Uptake and Degradation. Affiliated tissues include lung, endothelial and bone, and related mouse phenotypes are tumorigenesis and respiratory system.

Related Diseases for Posterior Urethral Valves

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Diseases in the Anterior Urethral Valve family:

posterior urethral valves

Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 450)
idRelated DiseaseScoreTop Affiliating Genes
1congenital anomalies of kidney and urinary tract31.8DSTYK, TBX18
2thyroiditis30.6IL6, TGFB1
3cryoglobulinemia30.1ACE, TNF
4crohn's disease30.0IL6, TNF
5chronic lymphocytic leukemia30.0ACE, AGT, IL6
6hemolytic anemia30.0IL6, TNF
7spinal muscular atrophy29.7IL6, TGFB1, TNF
8chronic venous insufficiency29.4ACE, AGTR1, IL6, TNF
9pelviureteric junction obstruction10.6
10endotheliitis10.6
11breast cancer10.5
12lymphoma10.5
13hepatitis10.5
14hiv-110.4
15leukemia10.4
16prostatitis10.4
17cerebritis10.4
18neuronitis10.4
19glandular cystitis10.4ACE, AGTR1
20schizophrenia10.3
21adenocarcinoma10.3
22spasticity10.3
23coxa vara, congenital10.3ACE, AGTR1
24pustulosis of palm and sole10.3ACE, TNF
25cerebral sarcoidosis10.3ACE, TNF
26neuroblastoma10.3
27colorectal cancer10.3
28malaria10.3
29lung cancer10.3
30heart disease10.3
31melanoma10.3
32retinitis10.3
33pancreatitis10.3
34subacute thyroiditis10.3
35ataxia10.3
36best1 retinopathy10.3TGFB1, TNF
37opisthorchiasis10.3TGFB1, TNF
38endogenous depression10.2ACE, AGTR1
39pediatric multiple sclerosis10.2ACE, AGT
40chromosome 9p deletion syndrome10.2ACE, TNF
41heart aneurysm10.2AGTR1, AGTR2
42prostate cancer10.2
43renal cell carcinoma10.2
44keratitis10.2
45phenylketonuria10.2
46b-cell lymphomas10.2
47cerebral palsy10.2
48gastric cancer10.2
49hemophagocytic lymphohistiocytosis10.2
50myelofibrosis10.2

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Symptoms for Posterior Urethral Valves

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Drugs & Therapeutics for Posterior Urethral Valves

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Drugs for Posterior Urethral Valves (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Fentanylapproved, illicit, investigationalPhase 2705437-38-73345
Synonyms:
1-Phenethyl-4-(N-phenylpropionamido)piperidine
1-Phenethyl-4-N-propionylanilinopiperidine
437-38-7
5-22-08-00049 (Beilstein Handbook Reference)
80832-90-2
990-73-8 (citrate)
AC1L1FQ2
Abstral
Actiq
BIDD:GT0555
BRN 0494484
CHEBI:119915
CHEMBL596
CID3345
D00320
DB00813
Duragesic
Duragesic (TN)
Duragesic-100
Duragesic-12
Duragesic-25
Duragesic-50
Duragesic-75
Durogesic
EINECS 207-113-6
Fentanest
Fentanil
Fentanil [DCIT]
Fentanila
Fentanila [INN-Spanish]
Fentanilo
Fentanyl
Fentanyl (JAN/USAN/INN)
Fentanyl - Novaplus
Fentanyl Citrate
Fentanyl [INN:BAN]
Fentanyl citrate
Fentanyl-100
 
Fentanyl-12
Fentanyl-25
Fentanyl-50
Fentanyl-75
Fentanylum
Fentanylum [INN-Latin]
HSDB 3329
IONSYS
JNS020QD
L001275
LS-124439
Lazanda
Matrifen
MolPort-003-847-369
N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-Phenethyl-4-piperidyl)propionanilide
N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide
N-Phenethyl-4-(N-propionylanilino)piperidine
N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
NCGC00168252-01
Nasalfent
Oprea1_152073
Oprea1_207148
PDSP1_000860
PDSP2_000846
Pentanyl
Phentanyl
Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)
R 4263
Rapinyl
Sentonil
Sublimase
Sublimaze
Subsys
UNII-UF599785JZ
fentanyl
2AnestheticsPhase 2, Phase 17385
3Antitubercular Agents1061
4Anti-Infective Agents17220
5Anti-Bacterial Agents9140
6Antibiotics, Antitubercular5971

Interventional clinical trials:

idNameStatusNCT IDPhase
1Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract ObstructionsNot yet recruitingNCT01552824Phase 2
2Fetal Cystoscopy for Lower Urinary Tract ObstructionRecruitingNCT02446184Phase 1
3CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral ValvesRecruitingNCT01537601
4Standardized Prenatal Clinical Care for LUTORecruitingNCT02315521

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

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Anatomical Context for Posterior Urethral Valves

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MalaCards organs/tissues related to Posterior Urethral Valves:

33
Lung, Endothelial, Bone, Liver, Prostate, Thyroid, Pituitary

Animal Models for Posterior Urethral Valves or affiliated genes

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MGI Mouse Phenotypes related to Posterior Urethral Valves:

38 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4ACE, AGTR2, IL6, TGFB1, TNF
2MP:00053888.3ACE2, IL6, TBX18, TGFB1, TNF
3MP:00053708.2ACE, AGT, IL6, TGFB1, TNF
4MP:00053818.1ACE2, AGTR2, IL6, TGFB1, TNF
5MP:00053867.2ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
6MP:00036317.2AGT, AGTR1, AGTR2, IL6, TBX18, TGFB1
7MP:00053757.2ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
8MP:00053696.9ACE2, AGT, AGTR2, IL6, TBX18, TGFB1
9MP:00053676.9ACE, ACE2, AGT, AGTR1, AGTR2, IL6
10MP:00053876.9ACE, ACE2, AGT, AGTR1, IL6, TGFB1
11MP:00053766.5ACE, ACE2, AGT, AGTR1, AGTR2, IL6
12MP:00107686.1ACE, ACE2, AGT, AGTR1, AGTR2, IL6
13MP:00053786.0ACE, ACE2, AGT, AGTR1, AGTR2, IL6
14MP:00053855.8ACE, ACE2, AGT, AGTR1, AGTR2, IL6

Publications for Posterior Urethral Valves

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Articles related to Posterior Urethral Valves:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy. (27157923)
2016
2
Hidradenitis Suppurativa: a pilot study to determine patients capability to self-assess their Hurley stage. (25354349)
2014
3
Alternaria keratitis and hypopyon after clear-cornea phacoemulsification. (24461506)
2014
4
Central and systemic responses to methionine-induced hyperhomocysteinemia in mice. (25153079)
2014
5
TFPI cofactor function of protein S: essential role of the protein S SHBG-like domain. (24740810)
2014
6
Myxopapillary ependymoma in the third ventricle area and sacral canal: dropped or retrograde metastasis? (23615415)
2013
7
A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack. (24300230)
2013
8
Prevalence of 10 human polyomaviruses in fecal samples from children with acute gastroenteritis: a case-control study. (23824769)
2013
9
Association of positive responses to suicide screening questions with hospital admission and repeated emergency department visits in children and adolescents. (24076609)
2013
10
Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain. (23185343)
2012
11
Blindness and visual impairment due to uncorrected refractive error in sub-Saharan Africa: review of recent population-based studies. (22317912)
2012
12
Requirement for zebrafish ataxin-7 in differentiation of photoreceptors and cerebellar neurons. (23226359)
2012
13
Polymorphism Ta89C of gene CYP17 promoter and polycystic ovary syndrome risk: a meta-analysis. (22237020)
2012
14
Development of diffuse large B-cell lymphoma in a patient with WaldenstrAPm's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms. (22184531)
2011
15
Aortic coarctation in the presence of capillary hemangioma. (21764546)
2011
16
Hypospadias repair with tubularized incised plate: Does the obstructive flow pattern resolve spontaneously? (20630805)
2011
17
A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. (20676397)
2010
18
A case study, calciphylaxis: an exercise in human caring. (20552851)
2009
19
Walking the line: a randomised trial on the effects of a short term walking programme on cognition in dementia. (19531688)
2009
20
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. (19718046)
2009
21
Reflex anuria affecting both kidneys following hysterectomy. (19112230)
2009
22
Frequency of social phobia and psychometric properties of the Liebowitz social anxiety scale in Parkinson's disease. (18661550)
2008
23
Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. (18652824)
2008
24
Epitheloid hemangioendothelioma of urinary bladder. (19468406)
2008
25
The metabolic syndrome: metabolic changes with vascular consequences. (17181562)
2007
26
Differential biofilm formation and motility associated with lipopolysaccharide/exopolysaccharide-coupled biosynthetic genes in Stenotrophomonas maltophilia. (16585771)
2006
27
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. (17157112)
2006
28
HLA-DPA1 promoter haplotypes are differently distributed in southern Chinese ethnic groups. (15713216)
2005
29
Primary structure, recombinant expression and homology modelling of human brain prolyl oligopeptidase, an important therapeutic target in the treatment of neuropsychiatric diseases. (15838896)
2005
30
Sleep oxygen desaturation and circulating leptin in obstructive sleep apnea-hypopnea syndrome. (15764749)
2005
31
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. (15326297)
2004
32
Post-triptan era for the treatment of acute migraine. (15361324)
2004
33
Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. (11950794)
2002
34
Cutaneous and mediastinal lymphadenitis due to Mycobacterium kansasii. (11545572)
2001
35
von Willebrand factor antigen levels in plasma of patients with malignant breast disease. (11514835)
2001
36
Takayasu's arteritis and tuberculosis: a case report. (11147763)
2000
37
The cultured human gastric cells HGT-1 express the principal transporters involved in acid secretion. (11041553)
2000
38
Regulation of chromatin and transcription by methyl-CpG binding proteins]. (11201105)
2000
39
Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. (10103198)
1999
40
Dual implication of 2',3'-cyclic nucleotide 3' phosphodiesterase as major autoantigen and C3 complement-binding protein in the pathogenesis of multiple sclerosis. (9576757)
1998
41
Animal models of cutaneous lupus erythematosus and lupus erythematosus photosensitivity. (9061668)
1997
42
Natural history study of hereditary multiple exostoses. (7702095)
1995
43
Molecular genetic analysis of a female patient with pyruvate dehydrogenase deficiency: detection of a new mutation and differential expression of mutant gene product in cultured cells. (8598635)
1995
44
Comparison of the immune response to recombinant gp120 in humans and chimpanzees. (7520248)
1994
45
The pathophysiology and molecular genetics of beta thalassemia. (8469250)
1993
46
Ammonia induced decrease in glial fibrillary acidic protein in cultured astrocytes. (2163437)
1990
47
Clear cell chondrosarcoma. A case report with topographic analysis. (2816367)
1989
48
Visceral larva migrans (toxocariasis) in Toronto. (7459767)
1981
49
LIPOID PROTEINOSIS (URBACH-WIETHE); REPORT OF A CASE AND REVIEW. (14196672)
1964
50

Variations for Posterior Urethral Valves

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Expression for genes affiliated with Posterior Urethral Valves

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Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for genes affiliated with Posterior Urethral Valves

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Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathwaysScoreTop Affiliating Genes
19.6ACE, ACE2
29.6ACE, ACE2
39.6TGFB1, TNF
49.3IL6, TGFB1
59.3IL6, TGFB1
69.1IL6, TNF
79.1ACE, AGT, AGTR1
8
Show member pathways
9.0ACE, ACE2, AGT
99.0AGT, TGFB1, TNF
108.8IL6, TGFB1, TNF
118.8IL6, TGFB1, TNF
128.8IL6, TGFB1, TNF
138.8IL6, TGFB1, TNF
148.8IL6, TGFB1, TNF
158.8IL6, TGFB1, TNF
168.8IL6, TGFB1, TNF
178.8IL6, TGFB1, TNF
188.8IL6, TGFB1, TNF
19
Show member pathways
8.8IL6, TGFB1, TNF
208.8IL6, TGFB1, TNF
21
Show member pathways
8.4ACE, IL6, TGFB1, TNF
22
Show member pathways
8.4ACE, IL6, TGFB1, TNF
238.3AGTR1, IL6, TGFB1, TNF
24
Show member pathways
8.2AGT, AGTR2, IL6, TGFB1
258.1AGT, IL6, TGFB1, TNF
26
Show member pathways
7.7ACE, ACE2, AGT, AGTR1, AGTR2, TGFB1
27
Show member pathways
7.4ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
28
Show member pathways
7.3AGT, AGTR1, AGTR2, IL6, TGFB1, TNF

GO Terms for genes affiliated with Posterior Urethral Valves

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Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:003294310.4ACE, TGFB1
2positive regulation of protein complex assemblyGO:003133410.2TGFB1, TNF
3regulation of renal output by angiotensinGO:000201910.2ACE, AGT
4positive regulation of superoxide anion generationGO:003293010.1AGT, TGFB1
5regulation of blood vessel size by renin-angiotensinGO:000203410.1AGT, AGTR1
6positive regulation of cytokine secretionGO:005071510.1AGTR2, TNF
7receptor biosynthetic processGO:003280010.1ACE2, TNF
8positive regulation of cholesterol esterificationGO:001087310.1AGT, AGTR1
9G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:000719910.1AGT, AGTR2
10negative regulation of neurotrophin TRK receptor signaling pathwayGO:005138710.1AGT, AGTR2
11renin-angiotensin regulation of aldosterone productionGO:000201810.1AGT, AGTR2
12negative regulation of myoblast differentiationGO:004566210.1TGFB1, TNF
13protein import into nucleus, translocationGO:000006010.0TGFB1, TNF
14positive regulation of macrophage derived foam cell differentiationGO:001074410.0AGT, AGTR1
15positive regulation of renal sodium excretionGO:00358159.9AGT, AGTR2
16positive regulation of reactive oxygen species metabolic processGO:20003799.9AGT, AGTR1
17regulation of blood pressureGO:00082179.9AGT, AGTR2
18epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.8IL6, TNF
19positive regulation of cytokine productionGO:00018199.8AGT, TNF
20cell growth involved in cardiac muscle cell developmentGO:00610499.7AGT, AGTR2
21negative regulation of lipid storageGO:00108889.7IL6, TNF
22positive regulation of branching involved in ureteric bud morphogenesisGO:00901909.7AGT, AGTR2, TGFB1
23positive regulation of cellular protein metabolic processGO:00322709.7AGT, AGTR1, TGFB1
24blood vessel remodelingGO:00019749.6ACE, AGT, AGTR2
25positive regulation of fibroblast proliferationGO:00481469.5AGT, TGFB1
26negative regulation of fat cell differentiationGO:00455999.2IL6, TGFB1, TNF
27T cell activationGO:00421109.2IL6, TGFB1
28cell surface receptor signaling pathwayGO:00071669.2AGT, AGTR2, TNF
29positive regulation of peptidyl-serine phosphorylationGO:00331389.2IL6, TGFB1, TNF
30negative regulation of gene expressionGO:00106299.1AGT, TGFB1, TNF
31positive regulation of protein kinase B signalingGO:00518979.1IL6, TGFB1, TNF
32positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.1AGT, IL6, TGFB1
33cellular response to dexamethasone stimulusGO:00715498.9AGTR2, IL6, TGFB1
34regulation of vasoconstrictionGO:00192298.8ACE, AGT, AGTR1
35positive regulation of NF-kappaB transcription factor activityGO:00510928.7AGT, IL6, TNF
36positive regulation of nitric oxide biosynthetic processGO:00454298.6AGT, AGTR2, IL6, TNF
37inflammatory responseGO:00069548.4AGTR2, IL6, TGFB1, TNF
38positive regulation of transcription, DNA-templatedGO:00458938.0AGT, AGTR2, IL6, TGFB1, TNF
39regulation of cell proliferationGO:00421278.0ACE2, AGT, AGTR1, TGFB1, TNF

Sources for Posterior Urethral Valves

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet