MCID: PST041
MIFTS: 42

Posterior Urethral Valves malady

Summaries for Posterior Urethral Valves

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33MalaCards
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MalaCards: Posterior Urethral Valves is related to vesicoureteral reflux and urinary tract obstruction. An important gene associated with Posterior Urethral Valves is AGTR1 (angiotensin II receptor, type 1), and among its related pathways are Thromboxane signalling through TP receptor and A-beta Uptake & Degradation. The compounds norepinephrine and temocaprilat have been mentioned in the context of this disorder. Affiliated tissues include kidney and prostate, and related mouse phenotypes are adipose tissue and muscle.

Aliases & Classifications for Posterior Urethral Valves

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

posterior urethral valves 43 61


Related Diseases for Posterior Urethral Valves

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Clinical Features for Posterior Urethral Valves

Drugs & Therapeutics for Posterior Urethral Valves

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Posterior Urethral Valves

Drug clinical trials:

Search ClinicalTrials for Posterior Urethral Valves

Search NIH Clinical Center for Posterior Urethral Valves

Search CenterWatch for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

Anatomical Context for Posterior Urethral Valves

Sources:
33MalaCards
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MalaCards organs/tissues related to Posterior Urethral Valves:

33
Kidney, Prostate

Animal Models for Posterior Urethral Valves or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Posterior Urethral Valves

Sources:
51PubMed
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Articles related to Posterior Urethral Valves:

(show top 50)    (show all 444)
idTitleAuthorsYear
1
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
2
Plasma renin activity: An early marker of progressive renal disease in posterior urethral valves. (24347867)
2013
3
Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves (PUV). (23946195)
2013
4
Early administration of oxybutynin improves bladder function and clinical outcomes in newborns with posterior urethral valves. (22910256)
2012
5
Delayed presentation of posterior urethral valves in discordant twins. (22305421)
2012
6
Long-term risk of end stage renal disease in patients with posterior urethral valves. (22014822)
2011
7
Vesicoureteral reflux in conjunction with posterior urethral valves. (19683736)
2009
8
Keyhole sign: how specific is it for the diagnosis of posterior urethral valves? (19642115)
2009
9
What is the effect of circumcision on risk of urinary tract infection in boys with posterior urethral valves? (19231547)
2009
10
Bladder neck contracture after antegrade fulguration of posterior urethral valves--unusual long-term complication. (19200590)
2009
11
Re: The effects of bladder neck incision on urodynamic abnormalities of children with posterior urethral valves. A. M. Kajbafzadeh, S. Payabvash and G. Karimian. J Urol 2007; 178: 2142-2149. (18436260)
2008
12
Fetoscopic transuterine release of posterior urethral valves: a new technique. (18033963)
2008
13
Long-term outcome of prenatally detected posterior urethral valves: single center study of 65 cases managed by primary valve ablation. (18006017)
2008
14
The long-term outcome of prenatally detected posterior urethral valves: a 10 to 23-year follow-up study. (18485035)
2008
15
Delayed presentation of posterior urethral valves in a child with autism. (16562391)
2006
16
Gene locus ambiguity in posterior urethral valves/prune-belly syndrome. (15912376)
2005
17
Congenital urethral anomalies in boys. Part I: posterior urethral valves. (17629874)
2005
18
Does mode of treatment affect the outcome of neonatal posterior urethral valves? (15126867)
2004
19
Posterior urethral valves in the adult: report of two cases. (15622939)
2004
20
Vesicoureteral reflux in patients with posterior urethral valves. (14501690)
2003
21
Prospective analysis of renal function and somatic growth in neonatal posterior urethral valves. (12369006)
2002
22
Limited surgical interventions in children with posterior urethral valves can lead to better outcomes following renal transplantation. (12390427)
2002
23
Posterior urethral valves. (11294257)
2001
24
Fetal surgery for posterior urethral valves: long-term postnatal outcomes. (11433086)
2001
25
Does neonatal pyeloureterostomy worsen bladder function in children with posterior urethral valves? (10958734)
2000
26
Urodynamic evaluation in boys treated for posterior urethral valves. (10415286)
1999
27
Special imaging casebook. Prune-belly syndrome with urachal diverticular calcification, posterior urethral valves, and patent utricle. (10645532)
1999
28
Incomplete hypospadiac urethral duplication with posterior urethral valves. (9880724)
1998
29
In utero urinary bladder perforation, urinary ascites, and bilateral contained urinomas secondary to posterior urethral valves: clinical and imaging findings. (8995156)
1997
30
Urinoma and urinary ascites secondary to calyceal perforation in neonatal posterior urethral valves. (9202574)
1997
31
Type III posterior urethral valves: presentation and management. (8926570)
1996
32
Early detection of bladder dysfunction following posterior urethral valves ablation. (8817210)
1996
33
Augmentation cystoplasty in boys with posterior urethral valves. (7609202)
1995
34
Parietal wall urinary extravasation and abdominal wall hernia secondary to posterior urethral valves in a neonate. (8535737)
1995
35
Posterior urethral valves: pathophysiology and clinical implications. (8141634)
1994
36
Normal growth with renal insufficiency owing to posterior urethral valves: value of long-term diversion. A twenty-year follow-up. (1585504)
1992
37
Urinary tract infections in children with posterior urethral valves after kidney transplantation. (1433626)
1992
38
Fetal bladder histology in posterior urethral valves and the prune belly syndrome. (2374202)
1990
39
Posterior urethral valves in adult males. (2368230)
1990
40
Late presentation of congenital posterior urethral valves. (2765774)
1989
41
Posterior urethral valves in the newborn: treatment and functional results. (3820017)
1987
42
The operative management of posterior urethral valves. (3440891)
1987
43
Posterior urethral valves: an update and review. (3317550)
1986
44
Endoscopic surgery of posterior urethral valves. (6529144)
1984
45
Posterior urethral valves in siblings. (6883056)
1983
46
The protean aspects of posterior urethral valves. (7321118)
1981
47
Posterior urethral valves in infants--a therapeutic approach. (658072)
1978
48
3 case reports of posterior urethral valves with varied presentations. (1021125)
1976
49
Current management of posterior urethral valves. (4428546)
1974
50
Radiographic and photoendoscopic studies in posterior urethral valves in enuretic boys. (4854008)
1974

Genetic Variations for Posterior Urethral Valves

Expression for genes affiliated with Posterior Urethral Valves

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Posterior Urethral Valves

Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for genes affiliated with Posterior Urethral Valves

Sources:
54Reactome, 12EMD Millipore, 53R&D Systems, 30KEGG, 50PharmGKB, 38NCBI BioSystems Database, 52QIAGEN
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Compounds for genes affiliated with Posterior Urethral Valves

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB
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Compounds related to Posterior Urethral Valves according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2411.9AGTR2
2temocaprilat459.9AGTR1, ACE
3cv 11974459.8AGTR1, AGT
4remikiren45 1110.7AGT, ACE
5benazepril hydrochloride609.7ACE, ACE2
6moexipril hydrochloride609.7ACE, ACE2
7perindopril erbumine609.7ACE2, ACE
8superoxide45 2410.7AGTR1, AGT
9lacidipine459.7AGTR1, ACE
10moexipril45 1110.6ACE, ACE2
11angiotensin iii299.6AGTR1, AGTR2
12captopril45 29 50 60 1113.6AGTR2, ACE2
13etoperidone459.6AGTR1, AGTR2
14angiotensin i299.6AGTR1, AGTR2
15trandolapril45 1110.5ACE, AGTR1
16aliskiren45 1110.5AGT, ACE, AGTR1
17Tasosartan119.5AGTR1, AGTR2
18eprosartan45 29 1111.5AGTR1, ACE, AGT
19olmesartan45 29 1111.5AGTR1, AGT, ACE
20chymostatin459.5AGTR1, AGT, ACE
21atenolol45 29 50 11 2413.5AGTR1, AGT, ACE
22hydrochlorothiazide45 50 29 11 2413.5AGT, ACE, AGTR1
23diltiazem45 29 1111.4AGTR1, ACE, AGT
24amlodipine45 50 11 2412.4AGT, ACE, AGTR1
25eplerenone45 60 29 1112.4AGTR1, ACE, ACE2
26enalaprilat459.4ACE2, ACE, AGT
27nadph45 2410.3ACE2, AGTR2
28cilazapril45 1110.2ACE, AGTR1
29cgp42112a459.2AGTR2, AGTR1, AGT
30spironolactone50 45 60 29 1113.1AGTR2, AGTR1, ACE
31lisinopril45 11 2411.0ACE2, AGTR1, AGT, ACE
32benazepril45 119.9TGFB1, ACE, AGT, AGTR1
33perindopril45 50 1110.9ACE, AGTR1, AGT, TGFB1
34nifedipine45 50 29 1111.8AGT, TGFB1, AGTR1, ACE
35ramipril45 119.8AGTR1, ACE, ACE2, TGFB1
36verapamil45 50 29 11 2412.8ACE, TGFB1, AGTR1
37saralasin458.7AGT, ACE, AGTR2, AGTR1
38pd12331945 299.7AGTR2, AGTR1, ACE, AGT
39valsartan45 60 29 1111.7AGT, AGTR1, AGTR2, ACE
40telmisartan45 29 1110.7AGTR1, AGTR2, AGT, ACE
41irbesartan45 29 50 1111.7AGT, ACE, AGTR1, AGTR2
42enalapril45 50 1110.7AGTR1, AGTR2, ACE, AGT
43angiotensin ii29 249.6AGTR2, AGTR1, ACE2, ACE
44prostacyclin458.6ACE, AGT, AGTR2, AGTR1
45sodium45 249.3AGT, ACE, AGTR1, AGTR2
46candesartan45 29 1110.1AGTR2, TGFB1, ACE, AGT, AGTR1
47ang ii458.1AGTR1, AGT, ACE, AGTR2, TGFB1
48losartan45 50 29 1111.1ACE, TGFB1, AGT, AGTR1, AGTR2
49creatinine458.0TGFB1, AGTR2, ACE, AGT, AGTR1
50nitric oxide45 11 2410.0AGT, AGTR1, ACE, ACE2, AGTR2

GO Terms for genes affiliated with Posterior Urethral Valves

Sources:
16Gene Ontology
See all sources

Cellular components related to Posterior Urethral Valves according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.4TGFB1, ACE2, ACE, AGT
2extracellular regionGO:0055767.2TGFB1, ACE2, ACE, AGT, AGTR2

Biological processes related to Posterior Urethral Valves according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.0AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.0AGT, AGTR1
3regulation of renal sodium excretionGO:03581310.0AGT, AGTR1
4positive regulation of cholesterol esterificationGO:0108739.9AGT, AGTR1
5regulation of renal output by angiotensinGO:0020199.9AGT, ACE
6low-density lipoprotein particle remodelingGO:0343749.9AGTR1, AGT
7angiotensin-mediated drinking behaviorGO:0030519.9ACE2, AGT
8positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGTR1, AGT
9angiotensin catabolic process in bloodGO:0020059.8ACE2, ACE
10positive regulation of superoxide anion generationGO:0329309.7AGT, TGFB1
11mononuclear cell proliferationGO:0329439.7ACE, TGFB1
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.7AGT, AGTR1
13regulation of inflammatory responseGO:0507279.7AGTR1, ACE2
14positive regulation of inflammatory responseGO:0507299.6AGT, AGTR1
15negative regulation of neurotrophin TRK receptor signaling pathwayGO:0513879.6AGT, AGTR2
16cellular sodium ion homeostasisGO:0068839.5AGT, AGTR2
17cell growth involved in cardiac muscle cell developmentGO:0610499.5AGT, AGTR2
18G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:0071999.5AGTR2, AGT
19positive regulation of reactive oxygen species metabolic processGO:20003799.5ACE2, AGTR1, AGT
20regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.4ACE2, AGTR1, ACE
21positive regulation of renal sodium excretionGO:0358159.4AGT, AGTR2
22regulation of vasodilationGO:0423129.4AGTR1, ACE, ACE2
23kidney developmentGO:0018229.4ACE, AGT, AGTR1
24nitric oxide mediated signal transductionGO:0072639.4AGTR2, AGT
25regulation of cell proliferationGO:0421279.4AGTR1, AGT, ACE2
26positive regulation of cellular protein metabolic processGO:0322709.4AGTR1, AGT, TGFB1
27angiotensin maturationGO:0020039.4ACE, ACE2, AGT
28positive regulation of extrinsic apoptotic signaling pathwayGO:20012389.4AGT, AGTR2
29cellular response to dexamethasone stimulusGO:0715499.3TGFB1, AGTR2
30regulation of cell growthGO:0015589.3AGT, AGTR1
31negative regulation of blood vessel endothelial cell migrationGO:0435379.3TGFB1, AGTR2
32renin-angiotensin regulation of aldosterone productionGO:0020189.2AGTR1, AGTR2, AGT
33blood vessel remodelingGO:0019749.1AGT, ACE, AGTR2
34regulation of blood pressureGO:0082179.0AGTR2, ACE
35regulation of vasoconstrictionGO:0192299.0ACE2, ACE, AGT, AGTR1
36positive regulation of branching involved in ureteric bud morphogenesisGO:0901909.0AGTR2, AGT, TGFB1
37G-protein coupled receptor signaling pathwayGO:0071868.9AGT, AGTR1, AGTR2
38negative regulation of cell growthGO:0303088.9TGFB1, AGTR2, AGT
39positive regulation of transcription, DNA-dependentGO:0458938.6AGTR2, TGFB1, AGT

Molecular functions related to Posterior Urethral Valves according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1acetyltransferase activator activityGO:0106989.8AGT, AGTR1
2bradykinin receptor bindingGO:0317119.7ACE, AGTR1
3peptidyl-dipeptidase activityGO:0082419.5ACE2, ACE
4carboxypeptidase activityGO:0041809.4ACE, ACE2
5metallopeptidase activityGO:0082379.4ACE2, ACE
6angiotensin type II receptor activityGO:0049459.3AGTR1, AGTR2
7endopeptidase activityGO:0041759.1ACE2, ACE
8peptide hormone bindingGO:0170469.0ACE2, AGTR2

Products for genes affiliated with Posterior Urethral Valves

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  • Proteins
  • Lysates
  • Antibodies

Sources for Posterior Urethral Valves

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet