MCID: PST041
MIFTS: 46

Posterior Urethral Valves malady

Categories: Rare diseases, Nephrological diseases, Fetal diseases

Aliases & Classifications for Posterior Urethral Valves

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Sources:
31ICD10 via Orphanet, 48NIH Rare Diseases, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Posterior Urethral Valves:

Name: Posterior Urethral Valves 48
Congenital Posterior Urethral Valves 68
 
Posterior Urethral Valve 54
Puv 54

Characteristics:

Orphanet epidemiological data:

54
posterior urethral valve:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Australia); Age of onset: Antenatal,Neonatal; Age of death: early childhood

Classifications:



External Ids:

Orphanet54 ORPHA93110
UMLS via Orphanet69 C0238506, C0542520
ICD10 via Orphanet31 Q64.2

Summaries for Posterior Urethral Valves

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Wikipedia:71 Posterior urethral valve (PUV) disorder is an obstructive developmental anomaly in the urethra and... more...

MalaCards based summary: Posterior Urethral Valves, also known as congenital posterior urethral valves, is related to congenital anomalies of kidney and urinary tract and urinary tract obstruction. An important gene associated with Posterior Urethral Valves is DSTYK (Dual Serine/Threonine And Tyrosine Protein Kinase), and among its related pathways are IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include lung, kidney and prostate, and related mouse phenotypes are Decreased substrate adherent cell growth and neoplasm.

Related Diseases for Posterior Urethral Valves

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Diseases in the Anterior Urethral Valve family:

posterior urethral valves

Diseases related to Posterior Urethral Valves via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1congenital anomalies of kidney and urinary tract32.7DSTYK, TBX18
2urinary tract obstruction29.9AGTR1, AGTR2, TGFB1
3sinusitis29.4ACE, TGFB1, TNF
4pyelonephritis28.8ACE, AGT, IL6, TNF
5urethritis11.1
6pelviureteric junction obstruction11.1
7pediatric ulcerative colitis10.5ACE, AGT
8familial hypopituitarism10.4AGT, AGTR1
9vibrio vulnificus infection10.3IL6, TGFB1
10vesicoureteral reflux10.3
11chronic diarrhea due to guanylate cyclase 2c overactivity10.3ACE, IL6
12marchiafava bignami disease10.3ACE, IL6
13podder-tolmie syndrome10.3AGT, AGTR1
14broad ligament malignant neoplasm10.2ACE, AGTR1
15hypopigmentation of eyelid10.2ACE, AGTR1, TGFB1
16prune belly syndrome10.2
17ovarian cancer10.2ACE, AGT, AGTR1
18casr-related disorders10.2ACE, AGT, AGTR1
19antiphospholipid syndrome10.2ACE, AGT, AGTR1
20chylocele of tunica vaginalis10.2ACE, AGT, AGTR1
21aortic valves stenosis of the child10.2ACE, AGT, AGTR1
22benign hypertensive renal disease10.2ACE, AGT, AGTR1
23renal tubular dysgenesis10.2ACE, AGT, AGTR1
24joint disorders10.2ACE, AGT, AGTR1
25collecting duct carcinoma10.2ACE, AGT, AGTR1
26herpetic gastritis10.2ACE, AGT, AGTR1
27down syndrome10.1
28congenital methemoglobinemia10.1AGTR1, IL6, TGFB1
29voyeurism10.1ACE, AGTR2
30uveoparotid fever10.1ACE, TNF
31acneiform dermatitis10.1ACE, TNF
32parsonage turner syndrome10.1TGFB1, TNF
33myopathy-growth delay-intellectual disability-hypospadias syndrome10.1TGFB1, TNF
34fatal infantile hypertrophic cardiomyopathy due to mitochondrial complex i deficiency10.1ACE, AGTR2, TGFB1
35pneumoconiosis due to talc10.1TGFB1, TNF
36urethral stricture10.1
37renal dysplasia10.1
38addison's disease10.0TGFB1, TNF
39panner disease10.0IL6, TNF
40aortic arch interruption10.0IL6, TNF
41imperforate anus10.0
42orchitis10.0
43ureterocele10.0
44epididymo-orchitis10.0
45anterior urethral valve10.0
46cutaneous leishmaniasis10.0IL6, TNF
47maligant granulosa cell tumor of ovary10.0IL6, TNF
48hemometra10.0IL6, TNF
49tricho odonto onycho dermal syndrome10.0IL6, TNF
50epstein-barr virus hepatitis9.9IL6, TNF

Graphical network of the top 20 diseases related to Posterior Urethral Valves:



Diseases related to posterior urethral valves

Symptoms & Phenotypes for Posterior Urethral Valves

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GenomeRNAi Phenotypes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00193-A-310.0AGTR1, AGTR2, DSTYK

MGI Mouse Phenotypes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ACE, AGTR2, IL6, TGFB1, TNF
2MP:00053697.8ACE2, AGT, AGTR2, IL6, TBX18, TGFB1
3MP:00053877.5ACE, ACE2, AGT, AGTR1, IL6, SLC3A1
4MP:00053757.5ACE, AGT, AGTR1, AGTR2, IL6, SLC3A1
5MP:00053857.2ACE, ACE2, AGT, AGTR1, AGTR2, IL6
6MP:00053766.9ACE, ACE2, AGT, AGTR1, AGTR2, IL6
7MP:00053786.6ACE, ACE2, AGT, AGTR1, AGTR2, IL6
8MP:00053676.6ACE, ACE2, AGT, AGTR1, AGTR2, IL6
9MP:00107686.6ACE, ACE2, AGT, AGTR1, AGTR2, IL6

Drugs & Therapeutics for Posterior Urethral Valves

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Drugs for Posterior Urethral Valves (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Fentanylapproved, illicit, investigational, vet_approvedPhase 2773437-38-73345
Synonyms:
1-Phenethyl-4-(N-phenylpropionamido)piperidine
1-Phenethyl-4-N-propionylanilinopiperidine
1-phenethyl-4-N-propionylanilinopiperidine
437-38-7
5-22-08-00049 (Beilstein Handbook Reference)
80832-90-2
990-73-8 (citrate)
AC1L1FQ2
Actiq
BIDD:GT0555
BRN 0494484
CHEBI:119915
CHEMBL596
CID3345
D00320
DB00813
Duragesic
Duragesic (TN)
Duragesic-100
Duragesic-12
Duragesic-25
Duragesic-50
Duragesic-75
Durogesic
EINECS 207-113-6
Fentanest
Fentanil
Fentanil [DCIT]
Fentanila
Fentanila [INN-Spanish]
Fentanilo
Fentanyl
Fentanyl (JAN/USAN/INN)
Fentanyl CII
Fentanyl [INN:BAN]
Fentanyl citrate
Fentanyl-100
Fentanyl-12
Fentanyl-25
 
Fentanyl-50
Fentanyl-75
Fentanylum
Fentanylum [INN-Latin]
HSDB 3329
IONSYS
JNS020QD
L001275
LS-124439
Matrifen
MolPort-003-847-369
N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-Phenethyl-4-piperidyl)propionanilide
N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidyl)propionanilide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide
N-Phenethyl-4-(N-propionylanilino)piperidine
N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenethyl-4-(N-propionylanilino)piperidine
N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
NCGC00168252-01
Nasalfent
Oprea1_152073
Oprea1_207148
PDSP1_000860
PDSP2_000846
Pentanyl
Phentanyl
Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)
R 4263
Rapinyl
Sentonil
Sublimase
Sublimaze
UNII-UF599785JZ
fentanyl
2
PancuroniumapprovedPhase 2315500-66-027350, 441289
Synonyms:
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(1-methylpiperidinium-1-yl)androstane dibromide
1,1'-(3,17-Bis(acetyloxy)androstane-2,16-diyl)bis(1-methylpiperidinium) dibromide
1,1'-(3alpha,17beta-Bis(acetyloxy)-5alpha-androstane-2beta,16beta-diyl)bis(1-methylpiperidinium) dibromide
1,1'-(3alpha,17beta-Dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methylpiperidinium) dibromide diacetate
1,1'-([2beta,3alpha,5alpha,16beta,17beta]-3,17-Bis[acetyloxy]androstane-2,16-diyl)bis(1-methylpiperidinium) dibromide
1,1'-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(Acetyloxy)androstane-2,16-diyl]bis(1-methylpiperidinium) dibromide
15500-66-0
2beta,16beta-Dipiperidino-5alpha-androstane-3alpha,17beta-diol diacetate dimethobromide
2beta,16beta-Dipiperidino-5alpha-androstane-3alpha,17beta-dioldiacetatedimethobromide
3-alpha,17-beta-Diacetoxy-2-beta,16-beta-dipiperidino-5-alpha-androstane dimethobromide
3alpha,17beta-Diacetoxy-2beta,16beta-dipiperidino-5alpha-androstane dimethobromide
3alpha,17beta-diacetoxy-2beta,16beta-bis(1-methylpiperidinium-1-yl)-5alpha-androstane
3alpha,17beta-diacetoxy-2beta,16beta-bis(1-methylpiperidinium-1-yl)-5alpha-androstane dibromide
5alpha-Androstan-3alpha,17beta-diol, 2beta,16beta-dipipecolinio-, dibromide, diacetate
AB00384328
AC1L1D1A
AC1L9AWJ
Ambap15500-66-0
BPBio1_001372
BSPBio_001247
Bromure de pancuronium
Bromure de pancuronium [INN-French]
Bromure de pancuronium [inn-french]
Bromuro de pancuronio
Bromuro de pancuronio [INN-Spanish]
Bromuro de pancuronio [inn-spanish]
C07551
C35H60N2O4
CHEBI:7907
CHEBI:7908
CHEMBL1200757
CHEMBL185073
CID27350
CID441289
D00492
DB01337
EINECS 239-532-5
EU-0100887
HMS1571O09
HMS2089M07
 
HSDB 3244
LS-116480
Lopac0_000887
Mioblock
MolPort-003-938-961
NA 97
NCGC00023037-03
NCGC00023037-04
NCGC00023037-05
NSC 293162
NSC293162
ORG NA 97
ORG-NA 97
P 1918
P1918_SIGMA
PANCURONIUM BROMIDE
Pancuronii bromidum
Pancuronii bromidum [INN-Latin]
Pancuronium
Pancuronium bromide
Pancuronium bromide (JP15/USAN/INN)
Pancuronium bromide [USAN:BAN:INN:JAN]
Pancuronium dibromide
Pavulon
Pavulon (TN)
Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl)-, dibromide
Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl-, dibromide
Piperidinium, 1,1'-(2-beta,16-beta-(3-alpha,17-beta-dihydroxy-5-alpha-androstanylene))bis(1-methyl-, dibromide, diacetate
Piperidinium, 1,1'-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methyl-, dibromide, diacetate
Piperidinium, 1,1'-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis(1-methyl-, dibromide, diacetate (8CI)
Piperidinium, 1,1'-[(2.beta.,3.alpha.,5.alpha.,16.beta.,17.beta.)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide
Poncuronium bromide
Prestwick0_001034
Prestwick1_001034
Prestwick2_001034
Prestwick3_001034
S2497_Selleck
SPBio_003098
UNII-U9LY9Y75X2
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate dibromide
pancuronium
3AnestheticsPhase 2, Phase 19001
4Antitubercular Agents1272
5Anti-Infective Agents21402
6Anti-Bacterial Agents10884
7Antibiotics, Antitubercular6972

Interventional clinical trials:

idNameStatusNCT IDPhase
1Fetal Cystoscopy Versus Vesico-amniotic Shunting in Severe Lower Urinary Tract ObstructionsNot yet recruitingNCT01552824Phase 2
2Fetal Cystoscopy for Lower Urinary Tract ObstructionRecruitingNCT02446184Phase 1
3CIRCumcision and Urinary Tract Infections in Boys With Posterior Urethral ValvesRecruitingNCT01537601
4Standardized Prenatal Clinical Care for LUTORecruitingNCT02315521

Search NIH Clinical Center for Posterior Urethral Valves

Genetic Tests for Posterior Urethral Valves

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Anatomical Context for Posterior Urethral Valves

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MalaCards organs/tissues related to Posterior Urethral Valves:

36
Lung, Kidney, Prostate, Testes, Spinal cord

Publications for Posterior Urethral Valves

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Articles related to Posterior Urethral Valves:

(show top 50)    (show all 547)
idTitleAuthorsYear
1
Outcome of Antenatally Presenting Posterior Urethral Valves (PUV) in Children. (28031548)
2016
2
Predicting risk of chronic kidney disease in infants and young children with posterior urethral valves at time of diagnosis: Objective analysis of initial ultrasound kidney characteristics and validation of parenchyma area as forecasters of renal reserve. (27017936)
2016
3
DNA copy number variants: A potentially useful predictor of early onset renal failure in boys with posterior urethral valves. (27160979)
2016
4
Posterior urethral valves: how the study of fetal micturition can help to reach the diagnosis? (27351949)
2016
5
Vesicostomy and Colostomy in a Premature Neonate With Posterior Urethral Valves, Bilateral Dysplastic Kidneys, and High Imperforate Anus: The Challenge of Stoma Placement. (27015939)
2016
6
Challenges in Predicting Renal Outcomes in Boys with Posterior Urethral Valves. (27311411)
2016
7
Posterior urethral valves and vesicoureteral reflux: can prenatal ultrasonography distinguish between these two conditions in male fetuses? (27374758)
2016
8
Genetic Basis of Posterior Urethral Valves Inheritance. (27261184)
2016
9
Controlled Outcomes for Achievement of Urinary Continence among Boys Treated for Posterior Urethral Valves. (26964916)
2016
10
Re: Nadir Creatinine in Posterior Urethral Valves: How High is Low Enough? (26853033)
2016
11
Rare copy number variants implicated in posterior urethral valves. (26663319)
2016
12
Re: Combined Creatinine Velocity and Nadir Creatinine: A Reliable Predictor of Renal Outcome in Neonatally Diagnosed Posterior Urethral Valves. (26887751)
2016
13
Posterior urethral valves (PUV) in pediatric practice - Promoting methods to understand how to diagnose and incise (PUV). (26921022)
2016
14
Posterior urethral valves: are neonatal imaging findings predictive of renal function during early childhood? (27401742)
2016
15
Laser Ablation of Posterior Urethral Valves by Fetal Cystoscopy. (25614247)
2015
16
Late diagnosis of posterior urethral valves. (26112258)
2015
17
Posterior urethral valve with unilateral vesicoureteral reflux and patent urachus: A rare combination of urinary tract anomaliess. (25836363)
2015
18
Study of prognostic significance of antenatal ultrasonography and renin angiotensin system activation in predicting disease severity in posterior urethral valves. (25829668)
2015
19
Concomitant anterior and posterior urethral valves in pediatrics: A single center experience over 12a88years and long-term follow up after endoscopic treatment. (25689730)
2015
20
Presentation, management, and outcome of posterior urethral valves in a Nigerian tertiary hospital. (25659544)
2015
21
Nadir creatinine in posterior urethral valves: How high is low enough? (26292912)
2015
22
Posterior Urethral Valves in Children: Pattern of Presentation and Outcome of Initial Treatment in Ile-Ife, Nigeria. (26425072)
2015
23
Re: Tran et al.: anterior urethral valve associated with posterior urethral valves: report of 2 cases and review of the literature (Urology 2014;84:469-471). (25733298)
2015
24
Combined creatinine velocity and nadir creatinine: A reliable predictor of renal outcome in neonatally diagnosed posterior urethral valves. (26062970)
2015
25
Concomitant Anterior and Posterior Urethral Valves: A Comprehensive Review of Literature. (25863834)
2015
26
Antenatal Determinants of Long-Term Kidney Outcome in Boys with Posterior Urethral Valves. (26375276)
2015
27
Posterior urethral valves: Metabolic consequences in a cohort of patients. (26096436)
2015
28
Posterior urethral valves: Risk factors for progression to renal failure. (26705688)
2015
29
Split-cuff nipple technique of ureteral reimplantation in children with thick-walled bladders due to posterior urethral valves. (25444631)
2015
30
Re: long-term bladder function, fertility and sexual function in patients with posterior urethral valves treated in infancy. (24331507)
2014
31
Posterior urethral polyp with type I posterior urethral valves: a rare association in a neonate. (24767515)
2014
32
Urological fistulas after fetal cystoscopic laser ablation of posterior urethral valves - surgical technical aspects. (24817027)
2014
33
The management of vesicoureteral reflux in the setting of posterior urethral valve with emphasis on bladder function and renal outcome: a single center cohort study. (24149109)
2014
34
Neonatal presentation of posterior urethral valves and tethered spinal cord. (25073498)
2014
35
Urinary tract tuberculosis in a child with late presentation posterior urethral valves. (24529021)
2014
36
Anterior urethral valve associated with posterior urethral valves: report of 2 cases and review of the literature. (24958476)
2014
37
Population-specific serum creatinine centiles in neonates with posterior urethral valves already predict long-term renal outcome. (25000449)
2014
38
Late presentation of posterior urethral valves. (24906275)
2014
39
Epidemiology and demography of recently diagnosed cases of posterior urethral valves. (25198372)
2014
40
Posterior urethral valves: determinants of outcome in a developing country. (23331631)
2013
41
Posterior urethral valves: Persistent renin angiotensin system activation after valve ablation and role of pre-emptive therapy with angiotensin converting enzyme-inhibitors on renal recovery. (23798811)
2013
42
Efficacy of bladder neck incision on urodynamic abnormalities in patients with posterior urethral valves. (23417544)
2013
43
Early outcome following diathermy versus cold knife ablation of posterior urethral valves. (22417679)
2013
44
Re: delayed presentation of posterior urethral valves in discordant twins. (23394670)
2013
45
Multiple urethral anomalies: anterior urethral diverticulum, posterior urethral valves, and distal hypospadias. (23331841)
2013
46
Did antenatal diagnosis protect against chronic kidney disease in patients with posterior urethral valves? A multicenter study. (24139350)
2013
47
Spontaneous rupture of kidney due to posterior urethral valve-diagnostic difficulties. (23795264)
2013
48
Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves (PUV). (23946195)
2013
49
Role of vesicostomy in the management ofA posterior urethral valve in Sub-Saharan Africa. (23849995)
2013
50
Long-term consequences of posterior urethral valves. (23871421)
2013

Variations for Posterior Urethral Valves

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Expression for genes affiliated with Posterior Urethral Valves

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Search GEO for disease gene expression data for Posterior Urethral Valves.

Pathways for genes affiliated with Posterior Urethral Valves

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Pathways related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
19.7IL6, TGFB1
29.6ACE, ACE2
39.4ACE, AGT, AGTR1
49.3TGFB1, TNF
5
Show member pathways
9.3ACE, ACE2, AGT
69.2IL6, TNF
78.9AGT, TGFB1, TNF
88.9IL6, TGFB1, TNF
98.9IL6, TGFB1, TNF
108.9IL6, TGFB1, TNF
11
Show member pathways
8.9IL6, TGFB1, TNF
128.9IL6, TGFB1, TNF
138.9IL6, TGFB1, TNF
148.9IL6, TGFB1, TNF
158.9IL6, TGFB1, TNF
168.9IL6, TGFB1, TNF
178.9IL6, TGFB1, TNF
188.5AGT, IL6, TGFB1, TNF
198.4AGTR1, IL6, TGFB1, TNF
20
Show member pathways
7.9ACE, AGT, AGTR1, AGTR2, IL6, TGFB1
21
Show member pathways
7.9ACE, ACE2, AGT, AGTR1, AGTR2, TGFB1
22
Show member pathways
7.4AGT, AGTR1, AGTR2, IL6, TGFB1, TNF

GO Terms for genes affiliated with Posterior Urethral Valves

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Cellular components related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.7ACE, ACE2, AGT, AGTR2, IL6, TGFB1
2extracellular spaceGO:00056157.6ACE, ACE2, AGT, IL6, TGFB1, TNF

Biological processes related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:003294310.6ACE, TGFB1
2positive regulation of protein tyrosine kinase activityGO:006109810.5ACE, AGT
3positive regulation of superoxide anion generationGO:003293010.5AGT, TGFB1
4low-density lipoprotein particle remodelingGO:003437410.5AGT, AGTR1
5neutrophil mediated immunityGO:000244610.4ACE, IL6
6positive regulation of cholesterol esterificationGO:001087310.4AGT, AGTR1
7positive regulation of macrophage derived foam cell differentiationGO:001074410.4AGT, AGTR1
8positive regulation of NAD(P)H oxidase activityGO:003386410.4AGT, AGTR1
9angiotensin catabolic process in bloodGO:000200510.4ACE, ACE2
10angiotensin-mediated drinking behaviorGO:000305110.3ACE2, AGT
11positive regulation of gap junction assemblyGO:190359810.3ACE2, AGT
12negative regulation of blood vessel endothelial cell migrationGO:004353710.3AGTR2, TGFB1
13cell growth involved in cardiac muscle cell developmentGO:006104910.2AGT, AGTR2
14cellular sodium ion homeostasisGO:000688310.2AGT, AGTR2
15G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerGO:000719910.2AGT, AGTR2
16regulation of renal output by angiotensinGO:000201910.2ACE, AGT
17negative regulation of neurotrophin TRK receptor signaling pathwayGO:005138710.2AGT, AGTR2
18nitric oxide mediated signal transductionGO:000726310.2AGT, AGTR2
19angiotensin-activated signaling pathwayGO:003816610.2AGTR1, AGTR2
20positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.2AGT, AGTR2
21positive regulation of renal sodium excretionGO:003581510.2AGT, AGTR2
22regulation of renal sodium excretionGO:003581310.1AGT, AGTR1
23kidney developmentGO:000182210.1ACE, AGT, AGTR1
24positive regulation of cellular protein metabolic processGO:003227010.1AGT, AGTR1, TGFB1
25negative regulation of myoblast differentiationGO:004566210.1TGFB1, TNF
26positive regulation of mononuclear cell migrationGO:007167710.0TGFB1, TNF
27angiotensin maturationGO:000200310.0ACE, ACE2, AGT
28positive regulation of protein complex assemblyGO:003133410.0TGFB1, TNF
29positive regulation of cytokine productionGO:000181910.0AGT, TNF
30positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.0AGT, IL6, TGFB1
31epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.0IL6, TNF
32negative regulation of lipid storageGO:00108889.9IL6, TNF
33positive regulation of chemokine productionGO:00327229.9IL6, TNF
34blood vessel remodelingGO:00019749.9ACE, AGT, AGTR2
35negative regulation of cell growthGO:00303089.9AGT, AGTR2, TGFB1
36positive regulation of branching involved in ureteric bud morphogenesisGO:00901909.9AGT, AGTR2, TGFB1
37positive regulation of reactive oxygen species metabolic processGO:20003799.9ACE2, AGT, AGTR1
38cellular response to dexamethasone stimulusGO:00715499.8AGTR2, IL6, TGFB1
39regulation of blood pressureGO:00082179.8ACE, AGT, AGTR2
40positive regulation of cytokine secretionGO:00507159.8AGTR2, TNF
41receptor biosynthetic processGO:00328009.8ACE2, TNF
42negative regulation of gene expressionGO:00106299.7ACE, TGFB1, TNF
43regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.7ACE, ACE2, AGTR1
44positive regulation of ERK1 and ERK2 cascadeGO:00703749.6DSTYK, IL6, TNF
45negative regulation of fat cell differentiationGO:00455999.6IL6, TGFB1, TNF
46positive regulation of peptidyl-serine phosphorylationGO:00331389.6IL6, TGFB1, TNF
47positive regulation of protein kinase B signalingGO:00518979.6IL6, TGFB1, TNF
48positive regulation of cell proliferationGO:00082849.4AGT, AGTR2, IL6, TGFB1
49regulation of vasodilationGO:00423129.3ACE, ACE2, AGTR1
50positive regulation of NF-kappaB transcription factor activityGO:00510929.2AGT, IL6, TGFB1, TNF

Molecular functions related to Posterior Urethral Valves according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.4ACE, AGTR1
2carboxypeptidase activityGO:000418010.3ACE, ACE2
3peptidyl-dipeptidase activityGO:000824110.3ACE, ACE2
4angiotensin type II receptor activityGO:000494510.1AGTR1, AGTR2
5growth factor activityGO:000808310.0AGT, IL6, TGFB1
6cytokine activityGO:00051259.5IL6, TGFB1, TNF
7protein heterodimerization activityGO:00469828.9AGTR1, SLC3A1, TBX18, TGFB1

Sources for Posterior Urethral Valves

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2CDC
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