MCID: PST053
MIFTS: 37

Postherpetic Neuralgia malady

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Summaries for Postherpetic Neuralgia

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Sources:
44NINDS, 65Wikipedia, 33MalaCards
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NINDS:44 Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox ? the varicella-zoster virus. The first sign of shingles is often burning or tingling pain, or sometimes numbness or itch, in one particular location on only one side of the body. After several days or a week, a rash of fluid-filled blisters, similar to chickenpox, appears in one area on one side of the body. Shingles pain can be mild or intense.

MalaCards: Postherpetic Neuralgia is related to arthritis and herpes zoster. An important gene associated with Postherpetic Neuralgia is HLA-A (major histocompatibility complex, class I, A), and among its related pathways are Endocytosis and Immune response Role of DAP12 receptors in NK cells. The compounds allopurinol and ursodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and testes.

Wikipedia:65 Postherpetic neuralgia is a nerve pain due to damage caused by the varicella zoster virus. Typically,... more...

Aliases & Classifications for Postherpetic Neuralgia

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44NINDS, 62UMLS
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Aliases & Descriptions:

postherpetic neuralgia 44 62


Related Diseases for Postherpetic Neuralgia

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17GeneCards, 18GeneDecks
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Diseases related to Postherpetic Neuralgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.2HLA-DRB1, HLA-A, HLA-B
2herpes zoster11.2
3blindness10.9
4neuropathy10.8
5peripheral neuropathy10.7
6diabetic neuropathy10.7
7herpes zoster ophthalmicus10.5
8neuronitis10.4
9cervicitis10.4
10polyneuropathy10.4
11axonal neuropathy10.2
12chickenpox10.2
13horner's syndrome10.2
14epidural abscess10.2
15radiculopathy10.2
16diabetic polyneuropathy10.2
17cerebritis10.2
18trigeminal neuralgia10.2
19herpes simplex10.2
20kidney disease10.2
21peptic ulcer disease10.2
22rheumatoid arthritis10.2
23spondylitis10.2
24vestibular disease10.2
25back pain10.2
26chronic pain10.2
27headache10.2
28myoclonus10.2
29spinal cord injury10.2
30stevens-johnson syndrome10.0HLA-A, HLA-B
31ankylosing spondylitis10.0HLA-B, HLA-A
32behcet's disease10.0HLA-A, HLA-B
33vaccinia10.0HLA-A, HLA-B
34hemochromatosis10.0HLA-B, HLA-A
35intraocular melanoma10.0HLA-A, HLA-B
36uveitis10.0HLA-B, HLA-A
37nasopharynx carcinoma10.0HLA-A, HLA-B
38hodgkin's lymphoma10.0HLA-A, HLA-B
39influenza10.0HLA-B, HLA-A
40hepatitis10.0HLA-A, HLA-B
41plasmodium falciparum malaria10.0HLA-DRB1, HLA-B
42primary biliary cirrhosis10.0HLA-B, HLA-DRB1
43type 1 diabetes mellitus10.0HLA-DRB1, HLA-A
44immunodeficiency with hyper igm type 210.0HLA-A, HLA-B
45autoimmune hepatitis10.0HLA-A, HLA-DRB1
46graft versus host disease10.0HLA-DRB1, HLA-A
47connective tissue disease10.0HLA-DRB1, HLA-A
48kidney cancer10.0HLA-A, HLA-B
49sarcoidosis10.0HLA-DRB1, HLA-A
50systemic scleroderma10.0HLA-A, HLA-DRB1

Graphical network of the top 20 diseases related to Postherpetic Neuralgia:



Diseases related to postherpetic neuralgia

Symptoms for Postherpetic Neuralgia

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Drugs & Therapeutics for Postherpetic Neuralgia

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Postherpetic Neuralgia

Search NIH Clinical Center for Postherpetic Neuralgia

Genetic Tests for Postherpetic Neuralgia

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Anatomical Context for Postherpetic Neuralgia

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33MalaCards
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MalaCards organs/tissues related to Postherpetic Neuralgia:

33
Skin, Spinal cord, Testes, Brain, Dorsal root ganglion, Eye, Heart, Kidney, T cells

Animal Models for Postherpetic Neuralgia or affiliated genes

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Publications for Postherpetic Neuralgia

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52PubMed
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Articles related to Postherpetic Neuralgia:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Impaired modulation of pain in patients with postherpetic neuralgia. (24427769)
2014
2
A phase 2a, randomized, crossover trial of gabapentin enacarbil for the treatment of postherpetic neuralgia in gabapentin inadequate responders. (24102928)
2013
3
Pregabalin hypersensitivity in a patient treated for postherpetic neuralgia. (24130391)
2013
4
Clinical development of a once-daily gastroretentive formulation of gabapentin for treatment of postherpetic neuralgia: an overview. (22809245)
2012
5
5% lidocaine medicated plaster in elderly patients with postherpetic neuralgia: results of a compassionate use programme in France. (21913735)
2011
6
Review of current guidelines on the care of postherpetic neuralgia. (21904096)
2011
7
Assessment of the quality of postherpetic neuralgia treatment information on the Internet. (21807567)
2011
8
QutenzaAr: a capsaicin 8% patch for the management of postherpetic neuralgia. (21158551)
2011
9
Efficacy of live zoster vaccine in preventing zoster and postherpetic neuralgia. (21294791)
2011
10
Herpes zoster pain, postherpetic neuralgia, and quality of life in the elderly. (21199312)
2011
11
Case report: successful epiradicular peripheral nerve stimulation of the C2 dorsal root ganglion for postherpetic neuralgia. (21992163)
2011
12
Successful treatment of an intractable postherpetic neuralgia (PHN) using peripheral nerve field stimulation (PNFS). (19700650)
2010
13
Time to onset of neuropathic pain reduction: A retrospective analysis of data from nine controlled trials of pregabalin for painful diabetic peripheral neuropathy and postherpetic neuralgia. (20393345)
2010
14
Eruption severity and characteristics in herpes zoster ophthalmicus: correlation with visual outcome, ocular complications, and postherpetic neuralgia. (19416378)
2009
15
Effect of temporary spinal cord stimulation on postherpetic neuralgia in the thoracic nerve area. (22151221)
2009
16
Postmarketing surveillance study of OxyContin tablets for relieving moderate to severe postherpetic neuralgia pain. (18758201)
2008
17
Visual vignette. Postherpetic neuralgia and galactorrhea. (18463051)
2008
18
Decompensation of chronic heart failure associated with pregabalin in a 73-year-old patient with postherpetic neuralgia: a case report. (18507657)
2008
19
Corticosteroids for preventing postherpetic neuralgia. (18254083)
2008
20
An integrative approach for treating postherpetic neuralgia--a case report. (17714107)
2007
21
Sequential medication strategies for postherpetic neuralgia: a cost-effectiveness analysis. (17241821)
2007
22
Inadequate evidence for a revised definition of postherpetic neuralgia (PHN). (17240068)
2007
23
Broad-band ultraviolet B phototherapy in zoster patients may reduce the incidence and severity of postherpetic neuralgia. (16948824)
2006
24
Chapter 44 Postherpetic neuralgia. (18808866)
2006
25
A Phase II, multicenter, randomized, double-blind, placebo-controlled crossover study of CJC-1008--a long-acting, parenteral opioid analgesic--in the treatment of postherpetic neuralgia. (17319450)
2006
26
Cost-effectiveness of pregabalin for the management of neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia: a Canadian perspective. (17213013)
2006
27
Transsacrococcygeal ganglion impar block for postherpetic neuralgia. (15983483)
2005
28
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. (15930418)
2005
29
Herpes zoster and postherpetic neuralgia: prevention and management. (16190505)
2005
30
VZV vasculopathy and postherpetic neuralgia: progress and perspective on antiviral therapy. (15642898)
2005
31
Use of the Rydel-Seiffer graduated tuning fork in the assessment of vibration threshold in postherpetic neuralgia patients and healthy controls. (15737809)
2005
32
Neuraxial and sympathetic blocks in herpes zoster and postherpetic neuralgia: an appraisal of current evidence. (15372391)
2004
33
Managing shingles and postherpetic neuralgia. Reactivation of the chickenpox virus causes severe pain and rash in older adults. (15153382)
2004
34
A study of shingles and the development of postherpetic neuralgia in East London. (12627483)
2003
35
Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. (12707429)
2003
36
Postherpetic neuralgia: a descriptive analysis of patients seen in pain clinics. (12945025)
2003
37
Local immune responses and systemic cytokine responses in zoster: relationship to the development of postherpetic neuralgia. (12562395)
2003
38
Current management of postherpetic neuralgia. (12801435)
2002
39
Postherpetic neuralgia. (12230700)
2002
40
Reduction of postherpetic neuralgia in herpes zoster. (11907852)
2001
41
Intrathecal methylprednisolone for postherpetic neuralgia. (11280323)
2001
42
Intrathecal methylprednisolone for intractable postherpetic neuralgia. (11087880)
2000
43
Psychiatric symptoms and distress differ between patients with postherpetic neuralgia and peripheral vestibular disease. (10750630)
2000
44
The role of sympathetic nerve blocks in herpes zoster and postherpetic neuralgia. (10924805)
2000
45
Gabapentin for postherpetic neuralgia. (10411191)
1999
46
Treatment of postherpetic neuralgia. (10079653)
1999
47
Postherpetic neuralgia: impact of famciclovir, age, rash severity, and acute pain in herpes zoster patients. (9852980)
1998
48
Unilateral postherpetic neuralgia is associated with bilateral sensory neuron damage. (9818935)
1998
49
Epidemiology and management of postherpetic neuralgia. (8840411)
1996
50
A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. (8364943)
1993

Variations for Postherpetic Neuralgia

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Expression for genes affiliated with Postherpetic Neuralgia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Postherpetic Neuralgia

Search GEO for disease gene expression data for Postherpetic Neuralgia.

Pathways for genes affiliated with Postherpetic Neuralgia

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50PathCards, 30KEGG, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN
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Pathways related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3HLA-B, HLA-A
2
Show member pathways
Immune response CD16 signaling in NK cells60
9.3HLA-B, HLA-A
3
Show member pathways
9.3HLA-B, HLA-A
49.3HLA-A, HLA-B
5
Show member pathways
9.3HLA-A, HLA-B
69.3HLA-A, HLA-B
7
Show member pathways
TCR signaling in naive CD8+ T cells38
9.0HLA-A, HLA-DRB1
8
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.0HLA-A, HLA-DRB1
98.5HLA-DRB1, HLA-A, HLA-B
108.5HLA-B, HLA-DRB1, HLA-A
11
Show member pathways
8.5HLA-DRB1, HLA-B, HLA-A
12
Show member pathways
8.5HLA-A, HLA-DRB1, HLA-B
13
Show member pathways
8.5HLA-B, HLA-DRB1, HLA-A
14
Show member pathways
8.5HLA-DRB1, HLA-B, HLA-A
158.5HLA-DRB1, HLA-A, HLA-B
168.5HLA-A, HLA-B, HLA-DRB1
17
Show member pathways
8.5HLA-A, HLA-B, HLA-DRB1

Compounds for genes affiliated with Postherpetic Neuralgia

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1allopurinol45 51 1111.5HLA-A, HLA-B
2ursodeoxycholic acid45 24 1111.5HLA-B, HLA-A
3carbamazepine45 51 1111.3HLA-A, HLA-B
4dr-10459.2HLA-DRB1, HLA-A
55-aza-2deoxycytidine459.2HLA-A, HLA-B
6tacrolimus45 51 1111.0HLA-B, HLA-A
7oligonucleotide458.6HLA-DRB1, HLA-A, HLA-B
8arginine458.6HLA-B, HLA-A, HLA-DRB1
9tyrosine458.5HLA-DRB1, HLA-A, HLA-B

GO Terms for genes affiliated with Postherpetic Neuralgia

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16Gene Ontology
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Cellular components related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.5HLA-B, HLA-A
2phagocytic vesicle membraneGO:0306709.4HLA-A, HLA-B
3early endosome membraneGO:0319019.3HLA-A, HLA-B
4cell surfaceGO:0099869.3HLA-A, HLA-B
5integral component of lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-B, HLA-A, HLA-DRB1
6ER to Golgi transport vesicle membraneGO:0125078.7HLA-B, HLA-A, HLA-DRB1
7Golgi membraneGO:0001398.6HLA-DRB1, HLA-A, HLA-B
8integral component of plasma membraneGO:0058878.4HLA-DRB1, HLA-A, HLA-B
9extracellular vesicular exosomeGO:0700628.2HLA-DRB1, HLA-A, HLA-B

Biological processes related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:0024869.6HLA-B, HLA-A
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.5HLA-A, HLA-B
3positive regulation of T cell mediated cytotoxicityGO:0019169.4HLA-A, HLA-B
4type I interferon signaling pathwayGO:0603379.4HLA-A, HLA-B
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.3HLA-B, HLA-A
6antigen processing and presentation of peptide antigen via MHC class IGO:0024749.3HLA-A, HLA-B
7antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.2HLA-A, HLA-B
8regulation of immune responseGO:0507769.0HLA-A, HLA-B
9detection of bacteriumGO:0160458.8HLA-DRB1, HLA-A, HLA-B
10interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-DRB1, HLA-A, HLA-B
11cytokine-mediated signaling pathwayGO:0192218.7HLA-DRB1, HLA-A, HLA-B
12immune responseGO:0069558.7HLA-B, HLA-A, HLA-DRB1

Molecular functions related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3HLA-A, HLA-B
2TAP bindingGO:0469779.0HLA-A, HLA-B
3peptide antigen bindingGO:0426058.4HLA-DRB1, HLA-A, HLA-B

Products for genes affiliated with Postherpetic Neuralgia

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Sources for Postherpetic Neuralgia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet