Aliases & Classifications for Postherpetic Neuralgia

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Postherpetic Neuralgia, Aliases & Descriptions:

Name: Postherpetic Neuralgia 42 60


Summaries for Postherpetic Neuralgia

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NINDS:42 Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox ? the varicella-zoster virus. The first sign of shingles is often burning or tingling pain, or sometimes numbness or itch, in one particular location on only one side of the body. After several days or a week, a rash of fluid-filled blisters, similar to chickenpox, appears in one area on one side of the body. Shingles pain can be mild or intense.

MalaCards based summary: Postherpetic Neuralgia is related to arthritis and herpes zoster. An important gene associated with Postherpetic Neuralgia is HLA-A (major histocompatibility complex, class I, A), and among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune response Role of DAP12 receptors in NK cells. The compounds allopurinol and ursodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and testes.

Wikipedia:63 Postherpetic neuralgia is a nerve pain due to damage caused by the varicella zoster virus. Typically,... more...

Related Diseases for Postherpetic Neuralgia

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Diseases related to Postherpetic Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.0HLA-DRB1, HLA-A, HLA-B
2herpes zoster11.2
3blindness10.9
4neuropathy10.9
5peripheral neuropathy10.7
6diabetic neuropathy10.7
7herpes zoster ophthalmicus10.6
8neuronitis10.5
9cervicitis10.5
10polyneuropathy10.4
11rheumatoid arthritis10.2
12spinal cord injury10.2
13axonal neuropathy10.2
14chickenpox10.2
15horner's syndrome10.2
16epidural abscess10.2
17radiculopathy10.2
18diabetic polyneuropathy10.2
19cerebritis10.2
20trigeminal neuralgia10.2
21herpes simplex10.2
22kidney disease10.2
23peptic ulcer disease10.2
24spondylitis10.2
25vestibular disease10.2
26back pain10.2
27chronic pain10.2
28headache10.2
29myoclonus10.2
30hypersensitivity syndrome, carbamazepine-induced10.1HLA-A, HLA-B
31spondyloarthropathy 110.1HLA-B, HLA-A
32behcet's disease10.1HLA-A, HLA-B
33vaccinia10.1HLA-A, HLA-B
34hemochromatosis10.1HLA-B, HLA-A
35uveal melanoma10.1HLA-A, HLA-B
36uveitis10.1HLA-B, HLA-A
37nasopharyngeal carcinoma10.1HLA-A, HLA-B
38hodgkin lymphoma10.1HLA-A, HLA-B
39influenza10.1HLA-B, HLA-A
40hepatitis10.0HLA-A, HLA-B
41plasmodium falciparum malaria10.0HLA-DRB1, HLA-B
42primary biliary cirrhosis10.0HLA-B, HLA-DRB1
43diabetes mellitus, insulin-dependent10.0HLA-DRB1, HLA-A
44hiv-110.0HLA-A, HLA-B
45autoimmune hepatitis10.0HLA-A, HLA-DRB1
46graft-versus-host disease, protection against10.0HLA-DRB1, HLA-A
47connective tissue disease10.0HLA-DRB1, HLA-A
48kidney cancer10.0HLA-A, HLA-B
49sarcoidosis 110.0HLA-DRB1, HLA-A
50systemic scleroderma9.9HLA-A, HLA-DRB1

Graphical network of the top 20 diseases related to Postherpetic Neuralgia:



Diseases related to postherpetic neuralgia

Symptoms for Postherpetic Neuralgia

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Drugs & Therapeutics for Postherpetic Neuralgia

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Drug clinical trials:

Search ClinicalTrials for Postherpetic Neuralgia

Search NIH Clinical Center for Postherpetic Neuralgia

Genetic Tests for Postherpetic Neuralgia

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Anatomical Context for Postherpetic Neuralgia

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MalaCards organs/tissues related to Postherpetic Neuralgia:

31
Skin, Spinal cord, Testes, Brain, Heart, Dorsal root ganglion, Eye, Kidney

Animal Models for Postherpetic Neuralgia or affiliated genes

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Publications for Postherpetic Neuralgia

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Articles related to Postherpetic Neuralgia:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Neuronal changes induced by Varicella Zoster Virus in a rat model of postherpetic neuralgia. (25880108)
2015
2
Predictors of postherpetic neuralgia in patients with herpes zoster: a pooled analysis of prospective cohort studies from North and Latin America and Asia. (25841633)
2015
3
Treatment of postherpetic neuralgia using a thoracic transforaminal epidural steroid injection. (25479280)
2015
4
Systematic review and meta-analysis of pharmacological therapies for pain associated with postherpetic neuralgia and less common neuropathic conditions. (24698515)
2014
5
Local and systemic cytokine expression in patients with postherpetic neuralgia. (25127283)
2014
6
A phase 2a, randomized, crossover trial of gabapentin enacarbil for the treatment of postherpetic neuralgia in gabapentin inadequate responders. (24102928)
2013
7
Pregabalin hypersensitivity in a patient treated for postherpetic neuralgia. (24130391)
2013
8
Clinical development of a once-daily gastroretentive formulation of gabapentin for treatment of postherpetic neuralgia: an overview. (22809245)
2012
9
5% lidocaine medicated plaster in elderly patients with postherpetic neuralgia: results of a compassionate use programme in France. (21913735)
2011
10
Review of current guidelines on the care of postherpetic neuralgia. (21904096)
2011
11
Assessment of the quality of postherpetic neuralgia treatment information on the Internet. (21807567)
2011
12
QutenzaAr: a capsaicin 8% patch for the management of postherpetic neuralgia. (21158551)
2011
13
Efficacy of live zoster vaccine in preventing zoster and postherpetic neuralgia. (21294791)
2011
14
Herpes zoster pain, postherpetic neuralgia, and quality of life in the elderly. (21199312)
2011
15
Successful treatment of an intractable postherpetic neuralgia (PHN) using peripheral nerve field stimulation (PNFS). (19700650)
2010
16
Time to onset of neuropathic pain reduction: A retrospective analysis of data from nine controlled trials of pregabalin for painful diabetic peripheral neuropathy and postherpetic neuralgia. (20393345)
2010
17
Eruption severity and characteristics in herpes zoster ophthalmicus: correlation with visual outcome, ocular complications, and postherpetic neuralgia. (19416378)
2009
18
Effect of temporary spinal cord stimulation on postherpetic neuralgia in the thoracic nerve area. (22151221)
2009
19
Postmarketing surveillance study of OxyContin tablets for relieving moderate to severe postherpetic neuralgia pain. (18758201)
2008
20
Visual vignette. Postherpetic neuralgia and galactorrhea. (18463051)
2008
21
Decompensation of chronic heart failure associated with pregabalin in a 73-year-old patient with postherpetic neuralgia: a case report. (18507657)
2008
22
Corticosteroids for preventing postherpetic neuralgia. (18254083)
2008
23
An integrative approach for treating postherpetic neuralgia--a case report. (17714107)
2007
24
Sequential medication strategies for postherpetic neuralgia: a cost-effectiveness analysis. (17241821)
2007
25
Broad-band ultraviolet B phototherapy in zoster patients may reduce the incidence and severity of postherpetic neuralgia. (16948824)
2006
26
Chapter 44 Postherpetic neuralgia. (18808866)
2006
27
A Phase II, multicenter, randomized, double-blind, placebo-controlled crossover study of CJC-1008--a long-acting, parenteral opioid analgesic--in the treatment of postherpetic neuralgia. (17319450)
2006
28
Transsacrococcygeal ganglion impar block for postherpetic neuralgia. (15983483)
2005
29
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. (15930418)
2005
30
Herpes zoster and postherpetic neuralgia: prevention and management. (16190505)
2005
31
VZV vasculopathy and postherpetic neuralgia: progress and perspective on antiviral therapy. (15642898)
2005
32
Use of the Rydel-Seiffer graduated tuning fork in the assessment of vibration threshold in postherpetic neuralgia patients and healthy controls. (15737809)
2005
33
Neuraxial and sympathetic blocks in herpes zoster and postherpetic neuralgia: an appraisal of current evidence. (15372391)
2004
34
Managing shingles and postherpetic neuralgia. Reactivation of the chickenpox virus causes severe pain and rash in older adults. (15153382)
2004
35
A study of shingles and the development of postherpetic neuralgia in East London. (12627483)
2003
36
Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. (12707429)
2003
37
Postherpetic neuralgia: a descriptive analysis of patients seen in pain clinics. (12945025)
2003
38
Local immune responses and systemic cytokine responses in zoster: relationship to the development of postherpetic neuralgia. (12562395)
2003
39
Current management of postherpetic neuralgia. (12801435)
2002
40
Postherpetic neuralgia. (12230700)
2002
41
Reduction of postherpetic neuralgia in herpes zoster. (11907852)
2001
42
Intrathecal methylprednisolone for intractable postherpetic neuralgia. (11087880)
2000
43
Psychiatric symptoms and distress differ between patients with postherpetic neuralgia and peripheral vestibular disease. (10750630)
2000
44
The role of sympathetic nerve blocks in herpes zoster and postherpetic neuralgia. (10924805)
2000
45
Gabapentin for postherpetic neuralgia. (10411191)
1999
46
Treatment of postherpetic neuralgia. (10079653)
1999
47
Postherpetic neuralgia: impact of famciclovir, age, rash severity, and acute pain in herpes zoster patients. (9852980)
1998
48
Unilateral postherpetic neuralgia is associated with bilateral sensory neuron damage. (9818935)
1998
49
Epidemiology and management of postherpetic neuralgia. (8840411)
1996
50
A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia. (8364943)
1993

Variations for Postherpetic Neuralgia

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Expression for genes affiliated with Postherpetic Neuralgia

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Search GEO for disease gene expression data for Postherpetic Neuralgia.

Pathways for genes affiliated with Postherpetic Neuralgia

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Pathways related to Postherpetic Neuralgia according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3HLA-A, HLA-B
2
Show member pathways
Immune response CD16 signaling in NK cells58
9.3HLA-A, HLA-B
39.3HLA-A, HLA-B
49.3HLA-A, HLA-B
5
Show member pathways
9.3HLA-A, HLA-B
6
Show member pathways
9.3HLA-A, HLA-B
7
Show member pathways
TCR signaling in naive CD8+ T cells36
9.0HLA-DRB1, HLA-A
8
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.0HLA-A, HLA-DRB1
98.5HLA-B, HLA-A, HLA-DRB1
10
Show member pathways
8.5HLA-B, HLA-A, HLA-DRB1
11
Show member pathways
8.5HLA-B, HLA-A, HLA-DRB1
12
Show member pathways
8.5HLA-B, HLA-A, HLA-DRB1
13
Show member pathways
8.5HLA-B, HLA-A, HLA-DRB1
148.5HLA-DRB1, HLA-A, HLA-B
158.5HLA-DRB1, HLA-A, HLA-B
16
Show member pathways
8.5HLA-DRB1, HLA-A, HLA-B
178.5HLA-DRB1, HLA-A, HLA-B

Compounds for genes affiliated with Postherpetic Neuralgia

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 24HMDB
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Compounds related to Postherpetic Neuralgia according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1allopurinol43 49 1211.5HLA-A, HLA-B
2ursodeoxycholic acid43 24 1211.5HLA-B, HLA-A
3carbamazepine43 49 1211.3HLA-A, HLA-B
4dr-10439.2HLA-DRB1, HLA-A
55-aza-2deoxycytidine439.2HLA-A, HLA-B
6tacrolimus43 49 1211.0HLA-B, HLA-A
7oligonucleotide438.6HLA-DRB1, HLA-A, HLA-B
8arginine438.6HLA-B, HLA-A, HLA-DRB1
9tyrosine438.5HLA-DRB1, HLA-A, HLA-B

GO Terms for genes affiliated with Postherpetic Neuralgia

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Cellular components related to Postherpetic Neuralgia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:00426129.5HLA-B, HLA-A
2phagocytic vesicle membraneGO:00306709.4HLA-B, HLA-A
3early endosome membraneGO:00319019.3HLA-A, HLA-B
4cell surfaceGO:00099869.3HLA-A, HLA-B
5integral component of lumenal side of endoplasmic reticulum membraneGO:00715568.7HLA-DRB1, HLA-A, HLA-B
6ER to Golgi transport vesicle membraneGO:00125078.7HLA-DRB1, HLA-A, HLA-B
7Golgi membraneGO:00001398.6HLA-DRB1, HLA-A, HLA-B
8integral component of plasma membraneGO:00058878.4HLA-B, HLA-A, HLA-DRB1
9extracellular vesicular exosomeGO:00700628.2HLA-DRB1, HLA-A, HLA-B

Biological processes related to Postherpetic Neuralgia according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentGO:00024869.6HLA-B, HLA-A
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00024809.5HLA-A, HLA-B
3positive regulation of T cell mediated cytotoxicityGO:00019169.4HLA-A, HLA-B
4type I interferon signaling pathwayGO:00603379.4HLA-A, HLA-B
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:00024799.3HLA-B, HLA-A
6antigen processing and presentation of peptide antigen via MHC class IGO:00024749.3HLA-A, HLA-B
7antigen processing and presentation of exogenous peptide antigen via MHC class IGO:00425909.2HLA-A, HLA-B
8regulation of immune responseGO:00507769.0HLA-A, HLA-B
9detection of bacteriumGO:00160458.8HLA-DRB1, HLA-A, HLA-B
10interferon-gamma-mediated signaling pathwayGO:00603338.7HLA-DRB1, HLA-A, HLA-B
11cytokine-mediated signaling pathwayGO:00192218.7HLA-DRB1, HLA-A, HLA-B
12immune responseGO:00069558.7HLA-B, HLA-A, HLA-DRB1

Molecular functions related to Postherpetic Neuralgia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.3HLA-A, HLA-B
2TAP bindingGO:00469779.0HLA-A, HLA-B
3peptide antigen bindingGO:00426058.4HLA-DRB1, HLA-A, HLA-B

Products for genes affiliated with Postherpetic Neuralgia

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Sources for Postherpetic Neuralgia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet