MCID: PST053
MIFTS: 22

Postherpetic Neuralgia malady

Summaries for Postherpetic Neuralgia

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Sources:
43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox ? the varicella-zoster virus. The first sign of shingles is often burning or tingling pain, or sometimes numbness or itch, in one particular location on only one side of the body. After several days or a week, a rash of fluid-filled blisters, similar to chickenpox, appears in one area on one side of the body. Shingles pain can be mild or intense.

MalaCards: Postherpetic Neuralgia is related to rheumatoid arthritis and herpes zoster. An important gene associated with Postherpetic Neuralgia is HLA-A (major histocompatibility complex, class I, A), and among its related pathways are COPII (Coat Protein 2) Mediated Vesicle Transport and Immune response IFN alpha/beta signaling pathway. The compounds ursodeoxycholic acid and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include skin.

Wikipedia:63 Postherpetic neuralgia is a nerve pain due to damage caused by the varicella zoster virus. Typically,... more...

Aliases & Classifications for Postherpetic Neuralgia

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43NINDS, 60UMLS
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Aliases & Descriptions:

postherpetic neuralgia 43 60


Related Diseases for Postherpetic Neuralgia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Postherpetic Neuralgia:



Diseases related to postherpetic neuralgia

Clinical Features for Postherpetic Neuralgia

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Drugs & Therapeutics for Postherpetic Neuralgia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Postherpetic Neuralgia

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Anatomical Context for Postherpetic Neuralgia

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32MalaCards
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MalaCards organs/tissues related to Postherpetic Neuralgia:

32
Skin

Animal Models for Postherpetic Neuralgia or affiliated genes

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Publications for Postherpetic Neuralgia

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Genetic Variations for Postherpetic Neuralgia

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Expression for genes affiliated with Postherpetic Neuralgia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Postherpetic Neuralgia

Search GEO for disease gene expression data for Postherpetic Neuralgia.

Pathways for genes affiliated with Postherpetic Neuralgia

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Sources:
53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Pathways related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.3HLA-B, HLA-A
2
Immune response IFN alpha/beta signaling pathway
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9.3HLA-A, HLA-B
3
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9.3HLA-A, HLA-B
49.3HLA-A, HLA-B
59.3HLA-A, HLA-B
6
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9.0HLA-A, HLA-DRB1
7
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9.0HLA-A, HLA-DRB1
88.5HLA-B, HLA-A, HLA-DRB1
98.5HLA-A, HLA-DRB1, HLA-B
10
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8.5HLA-B, HLA-DRB1, HLA-A
11
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8.5HLA-B, HLA-DRB1, HLA-A
128.5HLA-A, HLA-DRB1, HLA-B
13
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8.5HLA-A, HLA-DRB1, HLA-B
148.5HLA-A, HLA-DRB1, HLA-B
15
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8.5HLA-B, HLA-DRB1, HLA-A
16
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8.5HLA-A, HLA-B, HLA-DRB1

Compounds for genes affiliated with Postherpetic Neuralgia

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Sources:
44Novoseek, 11DrugBank, 24HMDB
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Compounds related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ursodeoxycholic acid44 11 2411.3HLA-B, HLA-A
25-aza-2deoxycytidine449.3HLA-B, HLA-A
3dr-10449.1HLA-DRB1, HLA-A
4oligonucleotide448.4HLA-A, HLA-DRB1, HLA-B
5arginine448.2HLA-A, HLA-B, HLA-DRB1

GO Terms for genes affiliated with Postherpetic Neuralgia

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Sources:
16Gene Ontology
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Cellular components related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.4HLA-B, HLA-A
2phagocytic vesicle membraneGO:0306709.2HLA-B, HLA-A
3early endosome membraneGO:0319019.0HLA-A, HLA-B
4integral to lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-B, HLA-DRB1, HLA-A
5ER to Golgi transport vesicle membraneGO:0125078.6HLA-A, HLA-DRB1, HLA-B
6Golgi membraneGO:0001398.5HLA-A, HLA-B, HLA-DRB1
7integral to plasma membraneGO:0058878.5HLA-B, HLA-DRB1, HLA-A

Biological processes related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.5HLA-B, HLA-A
2positive regulation of T cell mediated cytotoxicityGO:0019169.4HLA-A, HLA-B
3type I interferon-mediated signaling pathwayGO:0603379.4HLA-A, HLA-B
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.3HLA-A, HLA-B
5antigen processing and presentation of peptide antigen via MHC class IGO:0024749.3HLA-B, HLA-A
6antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.2HLA-B, HLA-A
7regulation of immune responseGO:0507769.0HLA-A, HLA-B
8detection of bacteriumGO:0160458.7HLA-B, HLA-DRB1, HLA-A
9interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-B, HLA-DRB1, HLA-A
10cytokine-mediated signaling pathwayGO:0192218.7HLA-DRB1, HLA-B, HLA-A
11immune responseGO:0069558.7HLA-A, HLA-DRB1, HLA-B

Molecular functions related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426058.5HLA-A, HLA-DRB1, HLA-B

Products for genes affiliated with Postherpetic Neuralgia

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Sources for Postherpetic Neuralgia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet