MCID: PST053
MIFTS: 34

Postherpetic Neuralgia malady

Summaries for Postherpetic Neuralgia

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Shingles (herpes zoster) is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chickenpox ? the varicella-zoster virus. The first sign of shingles is often burning or tingling pain, or sometimes numbness or itch, in one particular location on only one side of the body. After several days or a week, a rash of fluid-filled blisters, similar to chickenpox, appears in one area on one side of the body. Shingles pain can be mild or intense.

MalaCards: Postherpetic Neuralgia is related to herpes zoster and trigeminal neuralgia. An important gene associated with Postherpetic Neuralgia is HLA-A (major histocompatibility complex, class I, A), and among its related pathways are Immune response IFN alpha/beta signaling pathway and Endosomal/Vacuolar pathway. The compounds ursodeoxycholic acid and 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart.

Wikipedia:64 Postherpetic neuralgia is a nerve pain due to damage caused by the varicella zoster virus. Typically,... more...

Aliases & Classifications for Postherpetic Neuralgia

Sources:
44NINDS, 61UMLS
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Aliases & Descriptions:

postherpetic neuralgia 44 61


Related Diseases for Postherpetic Neuralgia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Postherpetic Neuralgia:



Diseases related to postherpetic neuralgia

Clinical Features for Postherpetic Neuralgia

Drugs & Therapeutics for Postherpetic Neuralgia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Postherpetic Neuralgia

Drug clinical trials:

Search ClinicalTrials for Postherpetic Neuralgia

Search NIH Clinical Center for Postherpetic Neuralgia

Search CenterWatch for Postherpetic Neuralgia

Genetic Tests for Postherpetic Neuralgia

Anatomical Context for Postherpetic Neuralgia

Sources:
33MalaCards
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MalaCards organs/tissues related to Postherpetic Neuralgia:

33
Brain, Spinal cord, Heart, Kidney, Skin, T cells, B cells, Dorsal root ganglion, Trigeminal ganglion

Animal Models for Postherpetic Neuralgia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Postherpetic Neuralgia

Sources:
51PubMed
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Articles related to Postherpetic Neuralgia:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
Relationship between pain relief and improvements in patient function/quality of life in patients with painful diabetic peripheral neuropathy or postherpetic neuralgia treated with pregabalin. (23541708)
2013
2
Role of impaired glucose metabolism in the postherpetic neuralgia. (23835767)
2013
3
Bee Venom Treatment for Refractory Postherpetic Neuralgia: A Case Report. (24093469)
2013
4
Botulinum Toxin A in Postherpetic Neuralgia: A Parallel, Randomized, Double-Blind, Single-Dose, Placebo-controlled Trial. (23370074)
2013
5
Capsaicin for postherpetic neuralgia, antenatal self-hypnosis training, Tai chi to reduce fall risk, acupuncture for acute low back pain, and biofeedback for tension headache. (24021474)
2013
6
Association of denervation severity in the dermis with the development of mechanical allodynia and hyperalgesia in a murine model of postherpetic neuralgia. (23400987)
2013
7
Effect of early stellate ganglion blockade for facial pain from acute herpes zoster and incidence of postherpetic neuralgia. (23159962)
2012
8
Once-daily gastroretentive gabapentin for the management of postherpetic neuralgia: an update for clinicians. (23342236)
2012
9
Chronic pain perspectives: Treating herpes zoster and postherpetic neuralgia: an evidence-based approach. (23000670)
2012
10
Successful treatment of refractory postherpetic neuralgia with topical gallium maltolate: case report. (22680305)
2012
11
Predictive factors for postherpetic neuralgia using ordered logistic regression analysis. (22209800)
2012
12
NGX-4010, a capsaicin 8% dermal patch, administered alone or in combination with systemic neuropathic pain medications, reduces pain in patients with postherpetic neuralgia. (21753727)
2012
13
Herpes zoster pain, postherpetic neuralgia, and quality of life in the elderly. (21199312)
2011
14
Prevent rather than treat postherpetic neuralgia by prescribing gabapentin earlier in patients with herpes zoster: comment on "incidence of postherpetic neuralgia after combination treatment with gabapentin and valacyclovir in patients with acute herpes zoster". (21844449)
2011
15
Protracted herpes zoster and severe postherpetic neuralgia after inadvertant infliximab administration. (21700542)
2011
16
Successful treatment of an intractable postherpetic neuralgia (PHN) using peripheral nerve field stimulation (PNFS). (19700650)
2010
17
Transcutaneous electroporation mediated delivery of doxepin-HPCD complex: a sustained release approach for treatment of postherpetic neuralgia. (19922748)
2010
18
A multicenter, randomized, double-blind, controlled dose finding study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. (20655809)
2010
19
Peripheral subcutaneous stimulation for the treatment of intractable postherpetic neuralgia: two case reports and literature review. (19226314)
2009
20
The effectiveness of repetitive paravertebral injections with local anesthetics and steroids for the prevention of postherpetic neuralgia in patients with acute herpes zoster. (19713253)
2009
21
Plasma vitamin C is lower in postherpetic neuralgia patients and administration of vitamin C reduces spontaneous pain but not brush-evoked pain. (19692796)
2009
22
A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: Differences in demographic data and sensory symptoms. (19592166)
2009
23
Decompensation of chronic heart failure associated with pregabalin in a 73-year-old patient with postherpetic neuralgia: a case report. (18507657)
2008
24
A review of the epidemiology of painful diabetic peripheral neuropathy, postherpetic neuralgia, and less commonly studied neuropathic pain conditions. (18211592)
2008
25
Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy. (17067740)
2007
26
Postherpetic neuralgia in older adults: culture, quality of life, and the use of alternative/complementary therapies. (17471050)
2007
27
Broad-band ultraviolet B phototherapy in zoster patients may reduce the incidence and severity of postherpetic neuralgia. (16948824)
2006
28
Chapter 44 Postherpetic neuralgia. (18808866)
2006
29
Treatment of postherpetic neuralgia with intravenous administration of vitamin C. (17122283)
2006
30
Prevention and treatment of postherpetic neuralgia. (16427472)
2006
31
Cost-effectiveness of a vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. (16954357)
2006
32
Transsacrococcygeal ganglion impar block for postherpetic neuralgia. (15983483)
2005
33
Analgesic therapy in postherpetic neuralgia: a quantitative systematic review. (16013891)
2005
34
The efficacy of local infiltration of triamcinolone acetonide with lignocaine compared with lignocaine alone in the treatment of postherpetic neuralgia. (16300701)
2005
35
Research shows that highly potent vaccine reduces the burden of herpes zoster and the incidence of postherpetic neuralgia in older adults. (16783098)
2005
36
Tolerability of treatments for postherpetic neuralgia. (15588117)
2004
37
Treatment of postherpetic neuralgia. (15550990)
2004
38
Change in opioid use after the initiation of gabapentin therapy in patients with postherpetic neuralgia. (14693306)
2003
39
Oral brivudin in comparison with acyclovir for herpes zoster: a survey study on postherpetic neuralgia. (12834861)
2003
40
Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. (12654988)
2003
41
Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. (12370455)
2002
42
Lidocaine patch 5% reduces pain intensity and interference with quality of life in patients with postherpetic neuralgia: an effectiveness trial. (15099237)
2002
43
Postherpetic neuralgia after shingles: an under-recognized cause of chronic vulvar pain. (12039124)
2002
44
Gabapentin in postherpetic neuralgia: a randomised, double blind, placebo controlled study. (11690735)
2001
45
Intrathecal methylprednisolone for postherpetic neuralgia. (11280319)
2001
46
Pyogenic spondylitis and epidural abscess distant from the site of continuous epidural block in a patient with postherpetic neuralgia. (14566520)
2001
47
Prospects for the prevention of postherpetic neuralgia in herpes zoster patients. (10870747)
2000
48
HLA-A33 and -B44 and susceptibility to postherpetic neuralgia (PHN). (10203019)
1999
49
Postherpetic neuralgia: irritable nociceptors and deafferentation. (9848092)
1998
50
The management of postherpetic neuralgia. (9497970)
1997

Genetic Variations for Postherpetic Neuralgia

Expression for genes affiliated with Postherpetic Neuralgia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Postherpetic Neuralgia

Search GEO for disease gene expression data for Postherpetic Neuralgia.

Pathways for genes affiliated with Postherpetic Neuralgia

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG
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Pathways related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response IFN alpha/beta signaling pathway
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9.3HLA-B, HLA-A
29.3HLA-B, HLA-A
39.3HLA-A, HLA-B
4
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9.3HLA-A, HLA-B
5
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9.3HLA-A, HLA-B
6
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9.0HLA-DRB1, HLA-A
7
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9.0HLA-DRB1, HLA-A
8
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8.5HLA-A, HLA-DRB1, HLA-B
9
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8.5HLA-B, HLA-DRB1, HLA-A
10
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8.5HLA-A, HLA-DRB1, HLA-B
118.5HLA-B, HLA-DRB1, HLA-A
128.5HLA-A, HLA-DRB1, HLA-B
138.5HLA-B, HLA-DRB1, HLA-A
148.5HLA-A, HLA-DRB1, HLA-B
15
Hide members
8.5HLA-A, HLA-DRB1, HLA-B
16
Hide members
8.5HLA-A, HLA-DRB1, HLA-B

Compounds for genes affiliated with Postherpetic Neuralgia

Sources:
45Novoseek, 11DrugBank, 24HMDB
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Compounds related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1ursodeoxycholic acid45 11 2411.3HLA-A, HLA-B
25-aza-2deoxycytidine459.3HLA-A, HLA-B
3dr-10459.1HLA-A, HLA-DRB1
4oligonucleotide458.4HLA-B, HLA-DRB1, HLA-A
5arginine458.2HLA-A, HLA-DRB1, HLA-B

GO Terms for genes affiliated with Postherpetic Neuralgia

Sources:
16Gene Ontology
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Cellular components related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.4HLA-A, HLA-B
2phagocytic vesicle membraneGO:0306709.2HLA-A, HLA-B
3early endosome membraneGO:0319019.0HLA-A, HLA-B
4integral to lumenal side of endoplasmic reticulum membraneGO:0715568.7HLA-A, HLA-DRB1, HLA-B
5ER to Golgi transport vesicle membraneGO:0125078.6HLA-A, HLA-DRB1, HLA-B
6Golgi membraneGO:0001398.5HLA-B, HLA-DRB1, HLA-A
7integral to plasma membraneGO:0058878.5HLA-A, HLA-DRB1, HLA-B

Biological processes related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0024809.5HLA-B, HLA-A
2positive regulation of T cell mediated cytotoxicityGO:0019169.4HLA-A, HLA-B
3type I interferon-mediated signaling pathwayGO:0603379.4HLA-A, HLA-B
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.3HLA-B, HLA-A
5antigen processing and presentation of peptide antigen via MHC class IGO:0024749.3HLA-A, HLA-B
6antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.2HLA-A, HLA-B
7regulation of immune responseGO:0507769.0HLA-A, HLA-B
8detection of bacteriumGO:0160458.7HLA-A, HLA-DRB1, HLA-B
9interferon-gamma-mediated signaling pathwayGO:0603338.7HLA-A, HLA-DRB1, HLA-B
10cytokine-mediated signaling pathwayGO:0192218.7HLA-A, HLA-DRB1, HLA-B
11immune responseGO:0069558.7HLA-B, HLA-DRB1, HLA-A

Molecular functions related to Postherpetic Neuralgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426058.5HLA-A, HLA-DRB1, HLA-B

Products for genes affiliated with Postherpetic Neuralgia

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Sources for Postherpetic Neuralgia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet