MCID: PST021
MIFTS: 58

Postpartum Depression malady

Mental diseases category
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Summaries for Postpartum Depression

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MedlinePlus:33 Many women have the baby blues after childbirth. if you have the baby blues, you may have mood swings, feel sad, anxious or overwhelmed, have crying spells, lose your appetite, or have trouble sleeping. the baby blues most often go away within a few days or a week. the symptoms are not severe and do not need treatment. the symptoms of postpartum depression last longer and are more severe. you may also feel hopeless and worthless, and lose interest in the baby. you may have thoughts of hurting yourself or the baby. very rarely, new mothers develop something even more serious. they may have hallucinations or try to hurt themselves or the baby. they need to get treatment right away, often in the hospital. postpartum depression can begin anytime within the first year after childbirth. the cause is not known. hormonal and physical changes after birth and the stress of caring for a new baby may play a role. women who have had depression are at higher risk. if you think you have postpartum depression, tell your health care provider. medicines, including antidepressants and talk therapy can help you get well. dept. of health and human services office on women's health

MalaCards based summary: Postpartum Depression, also known as maternity blues, is related to generalized anxiety disorder and obesity. An important gene associated with Postpartum Depression is CRH (corticotropin releasing hormone), and among its related pathways are Dopamine metabolism and Biogenic Amine Synthesis. The compounds carbon-11 and p-chloroamphetamine have been mentioned in the context of this disorder. Affiliated tissues include amygdala, cortex and thyroid, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Disease Ontology:8 An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth.

Wikipedia:65 Postpartum depression (PPD), also called postnatal depression, is a type of clinical depression which... more...

Aliases & Classifications for Postpartum Depression

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Postpartum Depression, Aliases & Descriptions:

Name: Postpartum Depression 8 33
Maternity Blues 8 62
Depression, Postpartum 62
 
Depression Postpartum 44
Postnatal Depression 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:9478
MeSH34 D019052

Related Diseases for Postpartum Depression

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Diseases related to Postpartum Depression via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1generalized anxiety disorder30.8SLC6A4, HTR1A
2obesity30.6HTR1A, COMT, MAOA, CRH
3personality disorder30.5SLC6A4, MAOA
4anxiety disorder30.4MAOA, CRH, BDNF, SLC6A4
5conduct disorder30.3COMT, MAOA, SLC6A4
6bipolar disorder30.3HTR1A, BDNF, SLC6A4
7infertility30.1PRL, ESR1, TPO
8thyroiditis30.0TPO, CALCA
9bulimia nervosa30.0COMT, MAOA, BDNF, SLC6A4
10mood disorder29.6HTR1A, COMT, MAOA, CRH, BDNF, SLC6A4
11migraine29.6PNOC, HTR1A, COMT, MAOA, CALCA, SLC6A4
12dementia29.5TPO, HTR1A, COMT, MAOA, BDNF
13hypoadrenalism10.5CRH
14paranoid schizophrenia10.5COMT
15pituitary carcinoma10.5PRL
16pervasive developmental disorder10.4SLC6A4
17breast fibroadenoma10.4ESR1
18li-fraumeni syndrome10.4ESR1
19melancholia10.4CRH, MAOA
20ovarian disease10.4ESR1
21serotonin syndrome10.4HTR1A, MAOA
22sheehan syndrome10.4PRL, CRH
23hypothalamic disease10.4PRL, CRH
24acth-secreting pituitary adenoma10.4PRL, CRH
25nelson syndrome10.4PRL, CRH
26substance abuse10.4CRH, SLC6A4
27neurogenic diabetes insipidus10.4PRL, OXT
28premature ejaculation10.4HTR1A, SLC6A4
29pituitary gland disease10.4PRL, CRH
30agoraphobia10.4HTR1A, MAOA
31blindness10.3
32acth deficiency10.3PRL, CRH
33diabetes insipidus10.3PRL, OXT
34amenorrhea10.3PRL, CRH
35antisocial personality disorder10.3MAOA, SLC6A4
36adrenal gland hyperfunction10.3PRL, CRH
37growth hormone deficiency10.3PRL, CRH
38hyperprolactinemia10.3PRL, CRH
39cushing's syndrome10.3PRL, CRH
40substance dependence10.3COMT, SLC6A4
41asperger syndrome10.3OXT, SLC6A4
42hyperthyroxinemia10.3TPO
43myoma10.3ESR1, OXT
44hypopituitarism10.3PRL, CRH
45drug addiction10.3CRH, BDNF
46cluster headache10.3PNOC, CALCA
47irritable bowel syndrome10.3CRH, SLC6A4
48alcohol abuse10.3COMT, SLC6A4
49sudden infant death syndrome10.2SLC6A4, HTR1A
50seasonal affective disorder10.2HTR1A, CRH, SLC6A4

Graphical network of the top 20 diseases related to Postpartum Depression:



Diseases related to postpartum depression

Symptoms for Postpartum Depression

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Drugs & Therapeutics for Postpartum Depression

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Drug clinical trials:

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Genetic Tests for Postpartum Depression

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Anatomical Context for Postpartum Depression

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MalaCards organs/tissues related to Postpartum Depression:

32
Amygdala, Cortex, Thyroid, Testes, Prefrontal cortex

Animal Models for Postpartum Depression or affiliated genes

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MGI Mouse Phenotypes related to Postpartum Depression:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.5TPO, ESR1, PRL, OXT, CRH, SLC6A4
2MP:00053857.5ESR1, OXT, HTR1A, COMT, MAOA, CALCA
3MP:00107687.3ESR1, OXT, HTR1A, CALCA, BDNF, SLC6A4
4MP:00107716.7PNOC, ESR1, PRL, OXT, CALCA, CRH
5MP:00036316.6HTR1A, OXT, PRL, ESR1, COMT, MAOA
6MP:00053766.2OXT, PRL, ESR1, TPO, HTR1A, COMT
7MP:00053865.9SLC6A4, PNOC, ESR1, PRL, OXT, HTR1A

Publications for Postpartum Depression

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Articles related to Postpartum Depression:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Postpartum Anxiety in a Cohort of Women from the General Population: Risk Factors and Association with Depression during Last Week of Pregnancy, Postpartum Depression and Postpartum PTSD. (25372562)
2014
2
Adult physical, sexual, and emotional abuse and postpartum depression, a population based, prospective study of 53,065 women in the Norwegian Mother and Child Cohort Study. (25199411)
2014
3
Surveys of postpartum depression in Miyagi, Japan, after the Great East Japan Earthquake. (25204487)
2014
4
Accuracy of brief screening tools for identifying postpartum depression among adolescent mothers. (24344102)
2014
5
Self-harm in postpartum depression and referrals to a perinatal mental health team: an audit study. (23462983)
2013
6
A multiple-baseline study of the effects associated with metacognitive therapy in postpartum depression. (23374492)
2013
7
Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial. (23993464)
2013
8
Postpartum depression among Thai women: a national survey. (24319843)
2013
9
Using short-term group psychotherapy as an evidence-based intervention for first-time mothers at risk for postpartum depression. (23819670)
2013
10
Web recruitment and internet use and preferences reported by women with postpartum depression after pregnancy complications. (23540519)
2013
11
Testing of a prototype Web based intervention for adolescent mothers on postpartum depression. (23473677)
2013
12
Postpartum depression in adolescent and adult mothers: comparing prenatal risk factors and predictive models. (22886352)
2013
13
Treating postpartum depression and anxiety naturally. (22694865)
2012
14
Risk factors for postpartum depression among abused and nonabused women. (23063016)
2012
15
Increased glutamate levels in the medial prefrontal cortex in patients with postpartum depression. (22805604)
2012
16
Postpartum depression: is mode of delivery a risk factor? (23304542)
2012
17
Using critical ethnography to explore issues among immigrant and refugee women seeking help for postpartum depression. (23146007)
2012
18
Reliability of the postpartum depression screening scale in the neonatal intensive care unit. (22960585)
2012
19
A frontotemporal dementia-like syndrome mimicking postpartum depression detected by 18F fluorodeoxyglucose positron emission tomography. (22889797)
2012
20
Postpartum depression is a family affair: addressing the impact on mothers, fathers, and children. (22757597)
2012
21
Acute administration of Zn, Mg, and thiamine improves postpartum depression conditions in mice. (22519381)
2012
22
Screening for postpartum depression in a pediatric emergency department. (21878826)
2011
23
Chronicity and severity of maternal postpartum depression and infant sleep disorders: a population-based cohort study in southern Brazil. (21211848)
2011
24
The evaluation of emotional facial expressions in early postpartum depression mood: a difference between adult and baby faces? (20667418)
2011
25
Chinese version of the Postpartum Depression Screening Scale: translation and validation. (21691238)
2011
26
Postpartum depression: the distribution of severity in a community sample. (21713455)
2011
27
The case for investigating postpartum depression in lesbians and bisexual women. (21521621)
2011
28
Experiences of postpartum depression among first-time mothers in mainland China. (20423413)
2010
29
Potential diagnostic markers for postpartum depression point out to altered immune signaling. (20029403)
2010
30
An exploratory study of postpartum depression and vitamin d. (21659271)
2010
31
The correlation between postpartum depression and health status. (19693658)
2010
32
Suffering in silence: a qualitative meta-data-analysis of postpartum depression. (19302513)
2009
33
A systematic review of home-based interventions to prevent and treat postpartum depression. (19137448)
2009
34
Postpartum depression and apical ballooning syndrome (takotsubo syndrome). (19772707)
2009
35
The role of traditional confinement practices in determining postpartum depression in women in Chinese cultures: a systematic review of the English language evidence. (19135261)
2009
36
Stepped care treatment of postpartum depression: impact on treatment, health, and work outcomes. (19734392)
2009
37
Spousal military deployment as a risk factor for postpartum depression. (19097519)
2008
38
State of the Science on postpartum depression: what nurse researchers have contributed--part 1. (18327112)
2008
39
Infanticide secrets: qualitative study on postpartum depression. (19074717)
2008
40
Shifting landscapes: immigrant women and postpartum depression. (18569046)
2008
41
Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis. (18413682)
2008
42
Prediction of postpartum depression by sociodemographic, obstetric and psychological factors: a prospective study. (18588594)
2008
43
Identifying postpartum depression: are 3 questions as good as 10? (18762505)
2008
44
A case study of postpartum depression & altered maternal-newborn attachment. (18453907)
2008
45
The impact of cultural factors upon postpartum depression: a literature review. (18569045)
2008
46
Postpartum depression: racial differences and ethnic disparities in a tri-racial and bi-ethnic population. (17955356)
2008
47
Symptoms of postpartum depression associated with elevated levels of interleukin-1 beta during the first month postpartum. (18829596)
2008
48
Risk for postpartum depression, breastfeeding practices, and mammary gland permeability. (18281356)
2008
49
Comparing postpartum depression and major depressive disorder: issues in assessment. (17654110)
2007
50
Postpartum depression screening by family nurse practitioners. (17535342)
2007

Variations for Postpartum Depression

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Expression for genes affiliated with Postpartum Depression

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Expression patterns in normal tissues for genes affiliated with Postpartum Depression

Search GEO for disease gene expression data for Postpartum Depression.

Pathways for genes affiliated with Postpartum Depression

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Pathways related to Postpartum Depression according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MAOA, COMT
2
Show member pathways
catecholamine biosynthesis37
9.9MAOA, COMT
39.9COMT, MAOA
4
Show member pathways
9.9COMT, MAOA
59.9MAOA, COMT
6
Show member pathways
Serotonin Transporter Activity37
9.8SLC6A4, MAOA
7
Show member pathways
9.5PRL, ESR1
89.5SLC6A4, MAOA, HTR1A
9
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.3MAOA, COMT, TPO
10
Show member pathways
Calcium Regulation in the Cardiac Cell37
9.2CRH, CALCA, OXT
11
Show member pathways
9.2HTR1A, COMT, MAOA, SLC6A4
129.1HTR1A, MAOA, BDNF, SLC6A4
13
Show member pathways
8.7PRL, MAOA, CALCA, CRH, BDNF
14
Show member pathways
7.8CRH, PNOC, PRL, OXT, HTR1A, CALCA
15
Show member pathways
7.2PNOC, ESR1, PRL, OXT, HTR1A, CALCA

Compounds for genes affiliated with Postpartum Depression

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Compounds related to Postpartum Depression according to GeneCards/GeneDecks:

(show top 50)    (show all 236)
idCompoundScoreTop Affiliating Genes
1carbon-11449.6SLC6A4, MAOA, HTR1A
2p-chloroamphetamine449.6HTR1A, MAOA, SLC6A4
35-hydroxytryptophan449.6CRH, HTR1A, PRL, SLC6A4
4sertraline44 28 50 24 1113.6CRH, HTR1A, MAOA, SLC6A4
5fenfluramine44 28 1111.6CRH, HTR1A, PRL, SLC6A4
6mdma449.5HTR1A, SLC6A4, MAOA, PRL
7pramipexole44 28 50 1112.5BDNF, PRL, COMT, HTR1A
8venlafaxine44 50 24 1112.4COMT, BDNF, SLC6A4, HTR1A
9rizatriptan44 28 1111.4CALCA, MAOA, HTR1A
10m-chlorophenylpiperazine449.4SLC6A4, HTR1A, PRL
11clomipramine44 50 1111.3PRL, MAOA, CRH, SLC6A4, HTR1A
12apomorphine28 44 1111.3PRL, OXT, COMT, HTR1A
13heroin44 50 1111.2COMT, CALCA, SLC6A4, BDNF
14desipramine44 50 1111.2SLC6A4, BDNF, CRH, MAOA, HTR1A
15maoa449.2BDNF, COMT, HTR1A, SLC6A4, MAOA
16fluvoxamine44 50 1111.2MAOA, BDNF, COMT, HTR1A, SLC6A4
17risperidone44 50 28 61 24 1114.2SLC6A4, HTR1A, BDNF, COMT, PRL
18levodopa44 1110.2COMT, MAOA, BDNF, PRL, HTR1A
19olanzapine44 50 28 24 1113.1PRL, HTR1A, COMT, BDNF, SLC6A4
20quetiapine44 50 28 24 1113.1SLC6A4, BDNF, PRL, HTR1A
21clozapine44 28 50 1112.1SLC6A4, BDNF, PRL, COMT, HTR1A
22mhpg448.9SLC6A4, BDNF, CRH, MAOA, COMT, PRL
23homovanillic acid44 249.9BDNF, SLC6A4, CRH, MAOA, COMT, PRL
24citalopram44 50 24 1111.9SLC6A4, CRH, BDNF, PRL, HTR1A, MAOA
25paroxetine44 50 28 1111.9BDNF, COMT, PRL, HTR1A, MAOA, SLC6A4
26methamphetamine44 50 1110.8SLC6A4, BDNF, MAOA, COMT
27choline44 24 1110.7OXT, COMT, MAOA, BDNF, SLC6A4
28nicotine44 28 50 1111.7OXT, COMT, CRH, SLC6A4, MAOA
29capsaicin44 289.6CALCA, BDNF, MAOA, CRH, PNOC
30thyroxine44 249.5TPO, CRH, OXT, PRL, CALCA
31opiate448.5SLC6A4, CRH, PNOC, PRL, OXT
32fluoxetine44 50 28 1111.4SLC6A4, BDNF, CRH, MAOA, HTR1A, OXT
33cocaine44 119.4PRL, CRH, BDNF, COMT, PNOC, SLC6A4
34gnrh448.3PRL, CRH, BDNF, SLC6A4, ESR1, OXT
35naloxone44 28 50 1111.3OXT, PNOC, ESR1, PRL, CRH
36nmda44 289.3PNOC, HTR1A, MAOA, BDNF, COMT, SLC6A4
37corticosterone44 61 2410.3HTR1A, CALCA, CRH, BDNF, PRL, SLC6A4
38estradiol44 24 1110.2BDNF, ESR1, PRL, CRH, OXT, COMT
39gaba448.1PNOC, BDNF, SLC6A4, OXT, CRH, MAOA
40acth448.1CALCA, HTR1A, TPO, OXT, PRL, BDNF
41acetylcholine44 50 28 24 1112.0CALCA, TPO, HTR1A, CRH, BDNF, PNOC
42epinephrine44 24 119.9COMT, SLC6A4, CALCA, MAOA, OXT, PRL
435-hydroxytryptamine447.8COMT, PNOC, PRL, MAOA, CALCA, CRH
44forskolin44 50 119.7BDNF, CRH, PNOC, CALCA, OXT, TPO
45steroid447.2TPO, PNOC, ESR1, PRL, OXT, CRH
46glutamate446.9OXT, SLC6A4, BDNF, CALCA, TPO, CRH
47norepinephrine44 24 118.8SLC6A4, BDNF, CRH, OXT, HTR1A, COMT
48dopamine44 28 24 119.8SLC6A4, BDNF, CRH, CALCA, COMT, HTR1A
49testosterone44 61 24 119.8MAOA, CALCA, CRH, BDNF, SLC6A4, PRL
50estrogen446.5MAOA, SLC6A4, CALCA, CRH, BDNF, OXT

GO Terms for genes affiliated with Postpartum Depression

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Cellular components related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:0431959.5CALCA, OXT
2extracellular regionGO:0055768.2BDNF, CRH, OXT, PNOC

Biological processes related to Postpartum Depression according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:01406210.2HTR1A, CRH
2dopamine catabolic processGO:04242010.2MAOA, COMT
3neurotransmitter catabolic processGO:04213510.1MAOA, COMT
4neurotransmitter biosynthetic processGO:04213610.1MAOA, COMT
5vasoconstrictionGO:04231010.0SLC6A4, HTR1A
6response to etherGO:04547210.0CRH, OXT
7behavioral fear responseGO:0016629.9HTR1A, BDNF
8sperm ejaculationGO:0427139.9SLC6A4, OXT
9response to painGO:0482659.8CRH, CALCA, COMT
10positive regulation of cAMP biosynthetic processGO:0308199.8CRH, CALCA
11positive regulation of ossificationGO:0457789.7OXT, CALCA
12learning or memoryGO:0076119.7CRH, BDNF
13positive regulation of synapse assemblyGO:0519659.7OXT, BDNF
14feeding behaviorGO:0076319.7BDNF, CRH, CALCA
15negative regulation of blood pressureGO:0457769.6OXT, CALCA, CRH
16regulation of heart rateGO:0020279.6CALCA, OXT
17response to drugGO:0424939.5SLC6A4, CRH, COMT
18female pregnancyGO:0075659.4CRH, COMT, OXT, PRL
19social behaviorGO:0351769.3SLC6A4, OXT
20response to estradiolGO:0323559.3ESR1, OXT, SLC6A4
21positive regulation of cytosolic calcium ion concentrationGO:0072049.1CALCA, OXT, ESR1
22synaptic transmissionGO:0072689.0PNOC, COMT, MAOA, CRH

Molecular functions related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4CRH, PNOC
2hormone activityGO:0051799.1CRH, CALCA, PRL

Products for genes affiliated with Postpartum Depression

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Sources for Postpartum Depression

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet