MCID: PST021
MIFTS: 57

Postpartum Depression malady

Mental diseases category
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Summaries for Postpartum Depression

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Many women have the baby blues after childbirth. if you have the baby blues, you may have mood swings, feel sad, anxious or overwhelmed, have crying spells, lose your appetite, or have trouble sleeping. the baby blues most often go away within a few days or a week. the symptoms are not severe and do not need treatment. the symptoms of postpartum depression last longer and are more severe. you may also feel hopeless and worthless, and lose interest in the baby. you may have thoughts of hurting yourself or the baby. very rarely, new mothers develop something even more serious. they may have hallucinations or try to hurt themselves or the baby. they need to get treatment right away, often in the hospital. postpartum depression can begin anytime within the first year after childbirth. the cause is not known. hormonal and physical changes after birth and the stress of caring for a new baby may play a role. women who have had depression are at higher risk. if you think you have postpartum depression, tell your health care provider. medicines, including antidepressants and talk therapy can help you get well. dept. of health and human services office on women's health

MalaCards: Postpartum Depression, also known as maternity blues, is related to obesity and anxiety disorder. An important gene associated with Postpartum Depression is CRH (corticotropin releasing hormone), and among its related pathways are Dopamine metabolism and Biogenic Amine Synthesis. The compounds carbon-11 and p-chloroamphetamine have been mentioned in the context of this disorder. Affiliated tissues include amygdala, testes and thyroid, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Disease Ontology:8 An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth.

Wikipedia:65 Postpartum depression (PPD), also called postnatal depression, is a type of clinical depression which... more...

Aliases & Classifications for Postpartum Depression

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Sources:
8Disease Ontology, 34MedlinePlus, 62UMLS, 45Novoseek, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

postpartum depression 8 34
maternity blues 8 62
depression, postpartum 62
depression postpartum 45
postnatal depression 8


External Ids:

Disease Ontology8 DOID:9478
MeSH35 D019052

Related Diseases for Postpartum Depression

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Postpartum Depression via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.4MAOA, HTR1A, COMT, CRH
2anxiety disorder30.3BDNF, SLC6A4, CRH, MAOA
3generalized anxiety disorder30.2HTR1A, SLC6A4
4personality disorder30.2SLC6A4, MAOA
5conduct disorder30.1SLC6A4, MAOA, COMT
6bipolar disorder30.1SLC6A4, BDNF, HTR1A
7thyroiditis30.0CALCA, TPO
8bulimia nervosa30.0MAOA, COMT, BDNF, SLC6A4
9infertility30.0PRL, ESR1, TPO
10mood disorder29.9COMT, MAOA, BDNF, SLC6A4, HTR1A, CRH
11migraine29.9HTR1A, COMT, MAOA, CALCA, SLC6A4, PNOC
12dementia29.9TPO, HTR1A, COMT, MAOA, BDNF
13insomnia10.3
14blindness10.3
15major depressive disorder10.2
16hypoadrenalism10.1CRH
17paranoid schizophrenia10.1COMT
18pituitary carcinoma10.1PRL
19pervasive developmental disorder10.1SLC6A4
20breast fibroadenoma10.1ESR1
21li-fraumeni syndrome10.1ESR1
22ovarian disease10.1ESR1
23melancholia10.1CRH, MAOA
24serotonin syndrome10.1HTR1A, MAOA
25sheehan syndrome10.1PRL, CRH
26hypothalamic disease10.1PRL, CRH
27acth-secreting pituitary adenoma10.1CRH, PRL
28nelson syndrome10.1CRH, PRL
29substance abuse10.1CRH, SLC6A4
30neurogenic diabetes insipidus10.1OXT, PRL
31premature ejaculation10.1SLC6A4, HTR1A
32agoraphobia10.1HTR1A, MAOA
33pituitary gland disease10.1CRH, PRL
34acth deficiency10.1CRH, PRL
35diabetes insipidus10.1PRL, OXT
36amenorrhea10.1CRH, PRL
37antisocial personality disorder10.1SLC6A4, MAOA
38adrenal gland hyperfunction10.1PRL, CRH
39growth hormone deficiency10.1CRH, PRL
40hyperprolactinemia10.1CRH, PRL
41cushing's syndrome10.1CRH, PRL
42substance dependence10.1SLC6A4, COMT
43asperger syndrome10.1SLC6A4, OXT
44hyperthyroxinemia10.1TPO
45myoma10.1OXT, ESR1
46hypopituitarism10.1PRL, CRH
47drug addiction10.1CRH, BDNF
48cluster headache10.1PNOC, CALCA
49irritable bowel syndrome10.1CRH, SLC6A4
50alcohol abuse10.1SLC6A4, COMT

Graphical network of the top 20 diseases related to Postpartum Depression:



Diseases related to postpartum depression

Symptoms for Postpartum Depression

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Drugs & Therapeutics for Postpartum Depression

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Postpartum Depression

Search NIH Clinical Center for Postpartum Depression

Genetic Tests for Postpartum Depression

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Anatomical Context for Postpartum Depression

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Sources:
33MalaCards
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MalaCards organs/tissues related to Postpartum Depression:

33
Amygdala, Testes, Thyroid, Cortex, Prefrontal cortex

Animal Models for Postpartum Depression or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Postpartum Depression:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.5SLC6A4, CRH, OXT, PRL, ESR1, TPO
2MP:00053857.5SLC6A4, CALCA, MAOA, COMT, HTR1A, OXT
3MP:00107687.3BDNF, CALCA, HTR1A, OXT, ESR1, TPO
4MP:00107716.7SLC6A4, PNOC, ESR1, PRL, OXT, CALCA
5MP:00036316.6SLC6A4, PRL, OXT, HTR1A, COMT, MAOA
6MP:00053766.2BDNF, SLC6A4, CALCA, MAOA, COMT, HTR1A
7MP:00053865.9SLC6A4, PRL, OXT, HTR1A, COMT, MAOA

Publications for Postpartum Depression

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Sources:
52PubMed
See all sources

Articles related to Postpartum Depression:

(show top 50)    (show all 496)
idTitleAuthorsYear
1
Accuracy of brief screening tools for identifying postpartum depression among adolescent mothers. (24344102)
2014
2
Self-harm in postpartum depression and referrals to a perinatal mental health team: an audit study. (23462983)
2013
3
A multiple-baseline study of the effects associated with metacognitive therapy in postpartum depression. (23374492)
2013
4
Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial. (23993464)
2013
5
Postpartum depression among Thai women: a national survey. (24319843)
2013
6
Using short-term group psychotherapy as an evidence-based intervention for first-time mothers at risk for postpartum depression. (23819670)
2013
7
Web recruitment and internet use and preferences reported by women with postpartum depression after pregnancy complications. (23540519)
2013
8
Testing of a prototype Web based intervention for adolescent mothers on postpartum depression. (23473677)
2013
9
Postpartum depression in adolescent and adult mothers: comparing prenatal risk factors and predictive models. (22886352)
2013
10
Treating postpartum depression and anxiety naturally. (22694865)
2012
11
Risk factors for postpartum depression among abused and nonabused women. (23063016)
2012
12
Increased glutamate levels in the medial prefrontal cortex in patients with postpartum depression. (22805604)
2012
13
Postpartum depression: is mode of delivery a risk factor? (23304542)
2012
14
Using critical ethnography to explore issues among immigrant and refugee women seeking help for postpartum depression. (23146007)
2012
15
Reliability of the postpartum depression screening scale in the neonatal intensive care unit. (22960585)
2012
16
A frontotemporal dementia-like syndrome mimicking postpartum depression detected by 18F fluorodeoxyglucose positron emission tomography. (22889797)
2012
17
Postpartum depression is a family affair: addressing the impact on mothers, fathers, and children. (22757597)
2012
18
Acute administration of Zn, Mg, and thiamine improves postpartum depression conditions in mice. (22519381)
2012
19
Working and short-term memories are impaired in postpartum depression. (22100126)
2012
20
Effects of repetitive transcranial magnetic stimulation on clinical, social, and cognitive performance in postpartum depression. (23118543)
2012
21
Screening for postpartum depression in a pediatric emergency department. (21878826)
2011
22
Chronicity and severity of maternal postpartum depression and infant sleep disorders: a population-based cohort study in southern Brazil. (21211848)
2011
23
The evaluation of emotional facial expressions in early postpartum depression mood: a difference between adult and baby faces? (20667418)
2011
24
Chinese version of the Postpartum Depression Screening Scale: translation and validation. (21691238)
2011
25
Postpartum depression: the distribution of severity in a community sample. (21713455)
2011
26
The case for investigating postpartum depression in lesbians and bisexual women. (21521621)
2011
27
Experiences of postpartum depression among first-time mothers in mainland China. (20423413)
2010
28
Potential diagnostic markers for postpartum depression point out to altered immune signaling. (20029403)
2010
29
An exploratory study of postpartum depression and vitamin d. (21659271)
2010
30
The correlation between postpartum depression and health status. (19693658)
2010
31
Suffering in silence: a qualitative meta-data-analysis of postpartum depression. (19302513)
2009
32
A systematic review of home-based interventions to prevent and treat postpartum depression. (19137448)
2009
33
Postpartum depression and apical ballooning syndrome (takotsubo syndrome). (19772707)
2009
34
The role of traditional confinement practices in determining postpartum depression in women in Chinese cultures: a systematic review of the English language evidence. (19135261)
2009
35
Stepped care treatment of postpartum depression: impact on treatment, health, and work outcomes. (19734392)
2009
36
Clinical inquiries. Can counseling prevent or treat postpartum depression? (19284943)
2009
37
Spousal military deployment as a risk factor for postpartum depression. (19097519)
2008
38
State of the Science on postpartum depression: what nurse researchers have contributed--part 1. (18327112)
2008
39
Infanticide secrets: qualitative study on postpartum depression. (19074717)
2008
40
Shifting landscapes: immigrant women and postpartum depression. (18569046)
2008
41
Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis. (18413682)
2008
42
Prediction of postpartum depression by sociodemographic, obstetric and psychological factors: a prospective study. (18588594)
2008
43
Identifying postpartum depression: are 3 questions as good as 10? (18762505)
2008
44
A case study of postpartum depression & altered maternal-newborn attachment. (18453907)
2008
45
The impact of cultural factors upon postpartum depression: a literature review. (18569045)
2008
46
Postpartum depression: racial differences and ethnic disparities in a tri-racial and bi-ethnic population. (17955356)
2008
47
Symptoms of postpartum depression associated with elevated levels of interleukin-1 beta during the first month postpartum. (18829596)
2008
48
Risk for postpartum depression, breastfeeding practices, and mammary gland permeability. (18281356)
2008
49
Comparing postpartum depression and major depressive disorder: issues in assessment. (17654110)
2007
50
Postpartum depression screening by family nurse practitioners. (17535342)
2007

Variations for Postpartum Depression

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Expression for genes affiliated with Postpartum Depression

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Postpartum Depression

Search GEO for disease gene expression data for Postpartum Depression.

Pathways for genes affiliated with Postpartum Depression

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 51PharmGKB, 30KEGG
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Pathways related to Postpartum Depression according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9COMT, MAOA
2
Show member pathways
catecholamine biosynthesis38
9.9MAOA, COMT
39.9MAOA, COMT
4
Show member pathways
9.9COMT, MAOA
59.9MAOA, COMT
6
Show member pathways
Serotonin Transporter Activity38
9.8MAOA, SLC6A4
7
Show member pathways
9.5PRL, ESR1
89.5MAOA, HTR1A, SLC6A4
9
Show member pathways
phenylalanine utilization38
noradrenaline and adrenaline degradation38
phenylalanine degradation IV38
9.3TPO, COMT, MAOA
10
Show member pathways
Calcium Regulation in the Cardiac Cell38
9.2CRH, OXT, CALCA
11
Show member pathways
9.2SLC6A4, MAOA, COMT, HTR1A
129.1MAOA, HTR1A, BDNF, SLC6A4
13
Show member pathways
8.7BDNF, CRH, PRL, MAOA, CALCA
14
Show member pathways
7.8PRL, CRH, CALCA, OXT, HTR1A, PNOC
15
Show member pathways
7.2PNOC, ESR1, PRL, OXT, HTR1A, CRH

Compounds for genes affiliated with Postpartum Depression

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 24HMDB, 11DrugBank, 61Tocris Bioscience
See all sources

Compounds related to Postpartum Depression according to GeneCards/GeneDecks:

(show top 50)    (show all 236)
idCompoundScoreTop Affiliating Genes
1carbon-11459.6SLC6A4, MAOA, HTR1A
2p-chloroamphetamine459.6HTR1A, MAOA, SLC6A4
35-hydroxytryptophan459.6CRH, HTR1A, PRL, SLC6A4
4sertraline45 29 51 24 1113.6CRH, HTR1A, MAOA, SLC6A4
5fenfluramine45 29 1111.6CRH, HTR1A, PRL, SLC6A4
6mdma459.5HTR1A, SLC6A4, MAOA, PRL
7pramipexole45 29 51 1112.5BDNF, PRL, COMT, HTR1A
8venlafaxine45 51 24 1112.4COMT, BDNF, SLC6A4, HTR1A
9rizatriptan45 29 1111.4CALCA, MAOA, HTR1A
10m-chlorophenylpiperazine459.4SLC6A4, HTR1A, PRL
11clomipramine45 51 1111.3PRL, MAOA, CRH, SLC6A4, HTR1A
12apomorphine29 45 1111.3PRL, OXT, COMT, HTR1A
13heroin45 51 1111.2COMT, CALCA, SLC6A4, BDNF
14desipramine45 51 1111.2SLC6A4, BDNF, CRH, MAOA, HTR1A
15maoa459.2BDNF, COMT, HTR1A, SLC6A4, MAOA
16fluvoxamine45 51 1111.2MAOA, BDNF, COMT, HTR1A, SLC6A4
17risperidone45 51 29 61 24 1114.2SLC6A4, HTR1A, BDNF, COMT, PRL
18levodopa45 1110.2COMT, MAOA, BDNF, PRL, HTR1A
19olanzapine45 51 29 24 1113.1PRL, HTR1A, COMT, BDNF, SLC6A4
20quetiapine45 51 29 24 1113.1SLC6A4, BDNF, PRL, HTR1A
21clozapine45 29 51 1112.1SLC6A4, BDNF, PRL, COMT, HTR1A
22mhpg458.9SLC6A4, BDNF, CRH, MAOA, COMT, PRL
23homovanillic acid45 249.9BDNF, SLC6A4, CRH, MAOA, COMT, PRL
24citalopram45 51 24 1111.9SLC6A4, CRH, BDNF, PRL, HTR1A, MAOA
25paroxetine45 51 29 1111.9BDNF, COMT, PRL, HTR1A, MAOA, SLC6A4
26methamphetamine45 51 1110.8SLC6A4, BDNF, MAOA, COMT
27choline45 24 1110.7OXT, COMT, MAOA, BDNF, SLC6A4
28nicotine45 29 51 1111.7OXT, COMT, CRH, SLC6A4, MAOA
29capsaicin45 299.6CALCA, BDNF, MAOA, CRH, PNOC
30thyroxine45 249.5TPO, CRH, OXT, PRL, CALCA
31opiate458.5SLC6A4, CRH, PNOC, PRL, OXT
32fluoxetine45 51 29 1111.4SLC6A4, BDNF, CRH, MAOA, HTR1A, OXT
33cocaine45 119.4PRL, CRH, BDNF, COMT, PNOC, SLC6A4
34gnrh458.3PRL, CRH, BDNF, SLC6A4, ESR1, OXT
35naloxone45 29 51 1111.3OXT, PNOC, ESR1, PRL, CRH
36nmda45 299.3PNOC, HTR1A, MAOA, BDNF, COMT, SLC6A4
37corticosterone45 61 2410.3HTR1A, CALCA, CRH, BDNF, PRL, SLC6A4
38estradiol45 24 1110.2BDNF, ESR1, PRL, CRH, OXT, COMT
39gaba458.1PNOC, BDNF, SLC6A4, OXT, CRH, MAOA
40acth458.1CALCA, HTR1A, TPO, OXT, PRL, BDNF
41acetylcholine45 51 29 24 1112.0CALCA, TPO, HTR1A, CRH, BDNF, PNOC
42epinephrine45 24 119.9COMT, SLC6A4, CALCA, MAOA, OXT, PRL
435-hydroxytryptamine457.8COMT, PNOC, PRL, MAOA, CALCA, CRH
44forskolin45 51 119.7BDNF, CRH, PNOC, CALCA, OXT, TPO
45steroid457.2TPO, PNOC, ESR1, PRL, OXT, CRH
46glutamate456.9OXT, SLC6A4, BDNF, CALCA, TPO, CRH
47norepinephrine45 24 118.8SLC6A4, BDNF, CRH, OXT, HTR1A, COMT
48dopamine45 29 24 119.8SLC6A4, BDNF, CRH, CALCA, COMT, HTR1A
49testosterone45 61 24 119.8MAOA, CALCA, CRH, BDNF, SLC6A4, PRL
50estrogen456.5MAOA, SLC6A4, CALCA, CRH, BDNF, OXT

GO Terms for genes affiliated with Postpartum Depression

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Sources:
16Gene Ontology
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Cellular components related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:0431959.5CALCA, OXT
2extracellular regionGO:0055768.2BDNF, CRH, OXT, PNOC

Biological processes related to Postpartum Depression according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:01406210.2HTR1A, CRH
2dopamine catabolic processGO:04242010.2MAOA, COMT
3neurotransmitter catabolic processGO:04213510.1COMT, MAOA
4neurotransmitter biosynthetic processGO:04213610.1COMT, MAOA
5vasoconstrictionGO:04231010.0HTR1A, SLC6A4
6response to etherGO:04547210.0CRH, OXT
7behavioral fear responseGO:0016629.9HTR1A, BDNF
8sperm ejaculationGO:0427139.9SLC6A4, OXT
9response to painGO:0482659.8CRH, CALCA, COMT
10positive regulation of cAMP biosynthetic processGO:0308199.8CALCA, CRH
11positive regulation of ossificationGO:0457789.7OXT, CALCA
12learning or memoryGO:0076119.7BDNF, CRH
13positive regulation of synapse assemblyGO:0519659.7BDNF, OXT
14feeding behaviorGO:0076319.7CALCA, BDNF, CRH
15negative regulation of blood pressureGO:0457769.6CRH, CALCA, OXT
16regulation of heart rateGO:0020279.6CALCA, OXT
17response to drugGO:0424939.5COMT, SLC6A4, CRH
18female pregnancyGO:0075659.4COMT, CRH, PRL, OXT
19social behaviorGO:0351769.3OXT, SLC6A4
20response to estradiolGO:0323559.3ESR1, OXT, SLC6A4
21positive regulation of cytosolic calcium ion concentrationGO:0072049.1OXT, CALCA, ESR1
22synaptic transmissionGO:0072689.0MAOA, CRH, PNOC, COMT

Molecular functions related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.4CRH, PNOC
2hormone activityGO:0051799.1CRH, CALCA, PRL

Products for genes affiliated with Postpartum Depression

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Sources for Postpartum Depression

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet