MCID: PST021
MIFTS: 54

Postpartum Depression malady

Summaries for Postpartum Depression

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Many women have the baby blues after childbirth. if you have the baby blues, you may have mood swings, feel sad, anxious or overwhelmed, have crying spells, lose your appetite, or have trouble sleeping. the baby blues most often go away within a few days or a week. the symptoms are not severe and do not need treatment. the symptoms of postpartum depression last longer and are more severe. you may also feel hopeless and worthless, and lose interest in the baby. you may have thoughts of hurting yourself or the baby. very rarely, new mothers develop something even more serious. they may have hallucinations or try to hurt themselves or the baby. they need to get treatment right away, often in the hospital. postpartum depression can begin anytime within the first year after childbirth. the cause is not known. hormonal and physical changes after birth and the stress of caring for a new baby may play a role. women who have had depression are at higher risk. if you think you have postpartum depression, tell your health care provider. medicines, including antidepressants and talk therapy can help you get well. dept. of health and human services office on women's health

MalaCards: Postpartum Depression, also known as maternity blues, is related to obesity and anxiety disorder. An important gene associated with Postpartum Depression is CRH (corticotropin releasing hormone), and among its related pathways are phenylalanine utilization and Tyrosine metabolism p.1 (dopamine) . The compounds estrogen and carbon-11 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, amygdala and cortex, and related mouse phenotypes are integument and nervous system.

Disease Ontology:8 An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth.

Wikipedia:63 Postpartum depression (PPD), also called postnatal depression, is a type of clinical depression which... more...

Aliases & Classifications for Postpartum Depression

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Sources:
8Disease Ontology, 33MedlinePlus, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

postpartum depression 8 33
maternity blues 8 60
depression, postpartum 60
depression postpartum 44
postnatal depression 8


External Ids:

Disease Ontology8 DOID:9478
MeSH34 D019052

Related Diseases for Postpartum Depression

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Postpartum Depression via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.3MAOA, CRH, HTR1A, COMT
2anxiety disorder30.2BDNF, CRH, MAOA, SLC6A4
3generalized anxiety disorder30.0SLC6A4, HTR1A
4substance abuse30.0CRH, SLC6A4
5neuroblastoma30.0BDNF
6personality disorder30.0MAOA, SLC6A4
7infertility30.0TPO, PRL
8conduct disorder30.0SLC6A4, MAOA, COMT
9thyroiditis30.0TPO, CALCA
10bipolar disorder30.0BDNF, HTR1A, SLC6A4
11bulimia nervosa29.9COMT, BDNF, MAOA, SLC6A4
12migraine29.9COMT, CALCA, HTR1A, MAOA, PNOC, SLC6A4
13dementia29.9TPO, MAOA, HTR1A, BDNF, COMT
14mood disorder29.9COMT, BDNF, HTR1A, CRH, MAOA, SLC6A4
15mental depression10.4
16major depressive disorder10.1
17olfactory neuroblastoma10.0
18tropical spastic paraparesis10.0
19multiple personality disorder10.0
20frontotemporal dementia10.0
21trigeminal neuralgia10.0
22osteoporosis10.0
23diarrhea10.0
24factitious disorder10.0
25meningioma10.0
26sleep disorder10.0
27wilson disease10.0PNOC
28cocaine dependence10.0SLC6A4
29nicotine dependence10.0SLC6A4
30cocaine abuse10.0SLC6A4
31hypoadrenalism10.0CRH
32fragile x syndrome10.0SLC6A4
33paranoid schizophrenia10.0COMT
34endometriosis10.0COMT
35hepatitis10.0COMT
36acute myocardial infarction10.0SLC6A4
37irritable bowel syndrome10.0SLC6A4, CRH
38melancholia10.0MAOA, CRH
39essential hypertension10.0COMT
40premature ejaculation10.0HTR1A, SLC6A4
41serotonin syndrome10.0HTR1A, MAOA
42diabetes mellitus10.0CALCA
43sudden infant death syndrome10.0SLC6A4, HTR1A
44hyperthyroxinemia10.0TPO
45amenorrhea10.0PRL, CRH
46diabetes insipidus10.0OXT, PRL
47antisocial personality disorder10.0SLC6A4, MAOA
48hypopituitarism10.0PRL, CRH
49anovulation10.0PRL
50hypothalamic disease10.0CRH, PRL

Graphical network of the top 20 diseases related to Postpartum Depression:



Diseases related to postpartum depression

Clinical Features for Postpartum Depression

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Drugs & Therapeutics for Postpartum Depression

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Postpartum Depression

Drug clinical trials:

Search ClinicalTrials for Postpartum Depression

Search NIH Clinical Center for Postpartum Depression

Search CenterWatch for Postpartum Depression

Genetic Tests for Postpartum Depression

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Anatomical Context for Postpartum Depression

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Sources:
32MalaCards
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MalaCards organs/tissues related to Postpartum Depression:

32
Thyroid, Amygdala, Cortex, Testes, Prefrontal cortex

Animal Models for Postpartum Depression or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Postpartum Depression:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.6CALCA, CRH, PRL, OXT, PNOC, SLC6A4
2MP:00036316.9COMT, BDNF, CALCA, HTR1A, CRH, PRL
3MP:00053766.7COMT, BDNF, CALCA, HTR1A, CRH, PRL
4MP:00053866.7SLC6A4, COMT, BDNF, CALCA, HTR1A, CRH

Publications for Postpartum Depression

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Sources:
50PubMed
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Articles related to Postpartum Depression:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
A tricky object to classify: evidence, postpartum depression and the DSM-IV. (23423822)
2013
2
Postpartum depression symptoms associated with Val158Met COMT polymorphism. (23636476)
2013
3
Postpartum depression: the (in) experience of Brazilian primary healthcare professionals. (22882356)
2013
4
Outcomes for collaborative care versus routine care in the management of postpartum depression. (23968267)
2013
5
The role of estrogen receptor I^ and nicotinic cholinergic receptors in postpartum depression. (23063492)
2013
6
Review of a research report on postpartum depression impacted by home health visits. (23367653)
2013
7
Online Screening and Referral for Postpartum Depression: An Exploratory Study. (23283485)
2013
8
Vitamin D Status during Pregnancy and the Risk of Subsequent Postpartum Depression: A Case-Control Study. (24312237)
2013
9
Cultural background and socioeconomic influence of immigrant and refugee women coping with postpartum depression. (22711219)
2013
10
Update on adolescent motherhood and postpartum depression. (23330798)
2013
11
Psychosocial and psychological interventions for preventing postpartum depression. (23450532)
2013
12
Reliability of the postpartum depression screening scale in the neonatal intensive care unit. (22960585)
2012
13
Nutrition and the psychoneuroimmunology of postpartum depression. (22853878)
2012
14
Research letter: is neuroticism a risk factor for postpartum depression? (22622082)
2012
15
Development and validation of a postpartum depression risk score in delivered women, Iran. (23833583)
2012
16
Clinically identified postpartum depression in Asian American mothers. (22536783)
2012
17
Chinese version of the Postpartum Depression Screening Scale: translation and validation. (21691238)
2011
18
The case for investigating postpartum depression in lesbians and bisexual women. (21521621)
2011
19
Risk for postpartum depression associated with assisted reproductive technologies and multiple births: a systematic review. (20605900)
2011
20
New Jersey's efforts to improve postpartum depression care did not change treatment patterns for women on medicaid. (21289351)
2011
21
Rapid habituation of ventral striatal response to reward receipt in postpartum depression. (21507385)
2011
22
Racial and ethnic disparities in postpartum depression care among low-income women. (21632730)
2011
23
Identifying mothers with postpartum depression early: integrating perinatal mental health care into the obstetric setting. (21941662)
2011
24
Cesarean section and postpartum depression in a cohort of Chinese women with a high cesarean delivery rate. (21877916)
2011
25
Prevalence and risk factors concerning postpartum depression among women within early postnatal periods in Turkey. (20191280)
2011
26
Postpartum depression among rural women from developed and developing countries: a systematic review. (21729155)
2011
27
Disparities in self-reported postpartum depression among Asian, Hawaiian, and Pacific Islander Women in Hawaii: Pregnancy Risk Assessment Monitoring System (PRAMS), 2004-2007. (19653084)
2010
28
Perimenopausal postpartum depression after conception by assisted reproductive technology. (20587765)
2010
29
Accuracy of depression screening tools for identifying postpartum depression among urban mothers. (20156899)
2010
30
Screening of postpartum depression: comparison between mothers in the neonatal intensive care unit and in the neonatal section. (20807154)
2010
31
Prenatal and postpartum depression in fathers and its association with maternal depression: a meta-analysis. (20483973)
2010
32
An association study between the Val66Met polymorphism of the BDNF gene and postpartum depression. (20169377)
2010
33
Suffering in silence: a qualitative meta-data-analysis of postpartum depression. (19302513)
2009
34
Postpartum depression screening at well-child visits: validity of a 2-question screen and the PHQ-9. (19139451)
2009
35
The influence of birth experience on postpartum depression. (19397148)
2009
36
Identification of postpartum depression. (19661761)
2009
37
Prediction of postpartum depression using multilayer perceptrons and pruning. (19387507)
2009
38
Postpartum depression treatment and breastfeeding. (19818241)
2009
39
The psychosocial work environment and maternal postpartum depression. (19288209)
2009
40
Postpartum depression in Asian cultures: a literature review. (19327773)
2009
41
Risk for postpartum depression, breastfeeding practices, and mammary gland permeability. (18281356)
2008
42
Association of postpartum depression with weight retention 1 year after childbirth. (18369338)
2008
43
A depression preventive intervention for rural low-income African-American pregnant women at risk for postpartum depression. (18982408)
2008
44
Therapeutic effects of folic acid on ante partum and postpartum depression. (18462888)
2008
45
Postpartum depression symptoms in newcomers. (18357931)
2008
46
Postpartum depression screening by family nurse practitioners. (17535342)
2007
47
Postpartum depression screening: importance, methods, barriers, and recommendations for practice. (17478661)
2007
48
Mental health and pregnancy. The link between prenatal and postpartum depression. (19998999)
2007
49
Not just a middle-class affliction: crafting a social work research agenda on postpartum depression. (18038730)
2007
50
Postpartum depression, an autoimmune disease? (17854751)
2007

Genetic Variations for Postpartum Depression

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Expression for genes affiliated with Postpartum Depression

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Postpartum Depression

Search GEO for disease gene expression data for Postpartum Depression.

Pathways for genes affiliated with Postpartum Depression

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 49PharmGKB, 29KEGG
See all sources

Compounds for genes affiliated with Postpartum Depression

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience
See all sources

Compounds related to Postpartum Depression according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1estrogen4410.1PNOC, SLC6A4
2carbon-11449.9HTR1A, MAOA, SLC6A4
3p-chloroamphetamine449.9SLC6A4, MAOA, HTR1A
4m-chlorophenylpiperazine449.9HTR1A, PRL, SLC6A4
5mcpp449.8HTR1A, PRL, SLC6A4
6rizatriptan44 28 1111.7CALCA, HTR1A, MAOA
75-hydroxytryptophan449.7CRH, HTR1A, PRL, SLC6A4
8fenfluramine28 44 1111.7SLC6A4, HTR1A, CRH, PRL
9mdma449.7MAOA, SLC6A4, PRL, HTR1A
10pindolol44 28 1111.6HTR1A, PRL, SLC6A4
11fluvoxamine44 49 1111.5BDNF, HTR1A, MAOA, SLC6A4
12forskolin44 49 1111.5PNOC, CRH, CALCA
13clomipramine44 49 1111.5HTR1A, CRH, PRL, SLC6A4, MAOA
14pramipexole44 49 28 1112.4HTR1A, BDNF, COMT, PRL
15desipramine44 49 1111.3SLC6A4, MAOA, CRH, HTR1A, BDNF
16citalopram49 44 11 2412.3MAOA, PRL, HTR1A, SLC6A4, BDNF
17methamphetamine44 49 1111.3BDNF, SLC6A4, COMT, MAOA
18ipsapirone44 2810.3OXT, PRL, HTR1A
19apomorphine44 28 1111.2OXT, HTR1A, COMT, PRL
20maoa449.2MAOA, COMT, SLC6A4, BDNF, HTR1A
21risperidone28 44 49 59 11 2414.2PRL, HTR1A, COMT, SLC6A4, BDNF
22mptp449.2MAOA, COMT, BDNF, SLC6A4
23clozapine44 28 49 1112.1SLC6A4, PRL, HTR1A, COMT, BDNF
24levodopa44 1110.1MAOA, COMT, BDNF, HTR1A, PRL
25olanzapine49 44 28 11 2413.0HTR1A, BDNF, COMT, PRL
26naloxone44 49 28 1112.0CRH, PNOC, OXT, PRL
27sertraline44 28 49 11 2413.0MAOA, DHRS9, CRH, HTR1A, SLC6A4
28mhpg449.0COMT, BDNF, CRH, PRL, MAOA, SLC6A4
29homovanillic acid44 2410.0SLC6A4, MAOA, PRL, CRH, BDNF, COMT
30nmda44 289.9COMT, HTR1A, BDNF, MAOA, PNOC
31capsaicin44 289.9PNOC, CRH, MAOA, BDNF, CALCA
32imipramine44 49 28 11 2412.9SLC6A4, BDNF, HTR1A, MAOA
33opiate448.8PRL, OXT, CRH, SLC6A4, PNOC
34nicotine44 49 28 1111.8MAOA, OXT, SLC6A4, COMT, CRH
35thyroxine44 249.8TPO, CALCA, CRH, PRL, OXT
36choline44 11 2410.7COMT, BDNF, OXT, MAOA, SLC6A4
37cocaine44 119.7COMT, BDNF, SLC6A4, PNOC, PRL, CRH
38acth448.6PRL, HTR1A, BDNF, CRH, TPO, OXT
39acetylcholine44 49 28 11 2412.5CALCA, HTR1A, PNOC, TPO, BDNF, CRH
405-hydroxytryptamine448.2COMT, PNOC, MAOA, PRL, CRH, HTR1A
41paroxetine44 49 28 1111.1MAOA, DHRS9, SLC6A4, PRL, HTR1A, BDNF
42epinephrine44 11 249.9COMT, SLC6A4, MAOA, OXT, PRL, CRH
43gaba447.6MAOA, PNOC, OXT, CRH, BDNF, SLC6A4
44fluoxetine49 44 28 1110.6HTR1A, OXT, DHRS9, SLC6A4, MAOA, PRL
45corticosterone44 59 249.5BDNF, CALCA, CRH, SLC6A4, DHRS9, OXT
46steroid447.4PRL, TPO, PNOC, DHRS9, OXT, BDNF
47glutamate447.3OXT, SLC6A4, COMT, BDNF, TPO, PNOC
48norepinephrine44 11 249.1BDNF, SLC6A4, PNOC, MAOA, OXT, PRL
49dopamine44 28 11 2410.1SLC6A4, BDNF, CALCA, COMT, HTR1A, CRH
50testosterone44 59 11 249.7SLC6A4, CALCA, PRL, BDNF, COMT, OXT

GO Terms for genes affiliated with Postpartum Depression

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Sources:
16Gene Ontology
See all sources

Cellular components related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9PNOC, OXT, PRL, CRH, CALCA, BDNF

Biological processes related to Postpartum Depression according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:01406210.2HTR1A, CRH
2dopamine catabolic processGO:04242010.1MAOA, COMT
3parturitionGO:00756710.1CRH, PRL
4neurotransmitter catabolic processGO:04213510.0MAOA, COMT
5vasoconstrictionGO:0423109.9SLC6A4, HTR1A
6neurotransmitter biosynthetic processGO:0421369.9MAOA, COMT
7response to etherGO:0454729.9OXT, CRH
8sperm ejaculationGO:0427139.8SLC6A4, OXT
9response to painGO:0482659.8CRH, CALCA, COMT
10feeding behaviorGO:0076319.7CRH, CALCA, BDNF
11positive regulation of ossificationGO:0457789.6OXT, CALCA
12response to estradiol stimulusGO:0323559.5PRL, OXT, SLC6A4
13negative regulation of blood pressureGO:0457769.5CALCA, CRH, OXT
14response to drugGO:0424939.5COMT, CRH, PRL, SLC6A4
15behavioral fear responseGO:0016629.5HTR1A, BDNF
16regulation of heart rateGO:0020279.4OXT, CALCA
17positive regulation of synapse assemblyGO:0519659.3BDNF, OXT
18female pregnancyGO:0075659.3OXT, PRL, CRH, COMT
19synaptic transmissionGO:0072689.2COMT, CRH, MAOA, PNOC

Molecular functions related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.7PNOC, CRH
2hormone activityGO:0051799.2PRL, CRH, CALCA

Products for genes affiliated with Postpartum Depression

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  • Antibodies
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Sources for Postpartum Depression

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet