MCID: PST021
MIFTS: 52

Postpartum Depression malady

Summaries for Postpartum Depression

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Many women have the baby blues after childbirth. if you have the baby blues, you may have mood swings, feel sad, anxious or overwhelmed, have crying spells, lose your appetite, or have trouble sleeping. the baby blues most often go away within a few days or a week. the symptoms are not severe and do not need treatment. the symptoms of postpartum depression last longer and are more severe. you may also feel hopeless and worthless, and lose interest in the baby. you may have thoughts of hurting yourself or the baby. very rarely, new mothers develop something even more serious. they may have hallucinations or try to hurt themselves or the baby. they need to get treatment right away, often in the hospital. postpartum depression can begin anytime within the first year after childbirth. the cause is not known. hormonal and physical changes after birth and the stress of caring for a new baby may play a role. women who have had depression are at higher risk. if you think you have postpartum depression, tell your health care provider. medicines, including antidepressants and talk therapy can help you get well. dept. of health and human services office on women's health

MalaCards: Postpartum Depression, also known as maternity blues, is related to anxiety disorder and substance abuse. An important gene associated with Postpartum Depression is CRH (corticotropin releasing hormone), and among its related pathways are phenylalanine utilization and Tyrosine metabolism p.1 (dopamine) . The compounds estrogen and carbon-11 have been mentioned in the context of this disorder. Affiliated tissues include cortex, thyroid and t cells, and related mouse phenotypes are integument and nervous system.

Disease Ontology:8 An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth.

Wikipedia:64 Postpartum depression (PPD), also called postnatal depression, is a type of clinical depression which... more...

Aliases & Classifications for Postpartum Depression

Sources:
8Disease Ontology, 34MedlinePlus, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

postpartum depression 8 34
maternity blues 8 61
depression, postpartum 61
depression postpartum 45
postnatal depression 8


External Ids:

Disease Ontology8 DOID:9478
MeSH35 D019052

Related Diseases for Postpartum Depression

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Postpartum Depression via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1anxiety disorder30.2BDNF, CRH, MAOA, SLC6A4
2substance abuse30.0CRH, SLC6A4
3infertility30.0TPO, PRL
4generalized anxiety disorder30.0SLC6A4, HTR1A
5bipolar disorder30.0BDNF, HTR1A, SLC6A4
6conduct disorder30.0SLC6A4, MAOA, COMT
7bulimia nervosa30.0COMT, BDNF, MAOA, SLC6A4
8insomnia10.3
9major depressive disorder10.2
10olfactory neuroblastoma10.0
11tropical spastic paraparesis10.0
12multiple personality disorder10.0
13frontotemporal dementia10.0
14bipolar i disorder10.0
15trigeminal neuralgia10.0
16osteoporosis10.0
17sleep disorder10.0
18spastic paraparesis10.0
19chronic pain10.0
20wilson disease10.0PNOC
21cocaine dependence10.0SLC6A4
22nicotine dependence10.0SLC6A4
23hypoadrenalism10.0CRH
24cocaine abuse10.0SLC6A4
25fragile x syndrome10.0SLC6A4
26paranoid schizophrenia10.0COMT
27endometriosis10.0COMT
28hepatitis10.0COMT
29acute myocardial infarction10.0SLC6A4
30irritable bowel syndrome10.0SLC6A4, CRH
31melancholia10.0MAOA, CRH
32essential hypertension10.0COMT
33premature ejaculation10.0HTR1A, SLC6A4
34serotonin syndrome10.0HTR1A, MAOA
35diabetes mellitus10.0CALCA
36sudden infant death syndrome10.0SLC6A4, HTR1A
37hyperthyroxinemia10.0TPO
38amenorrhea10.0PRL, CRH
39diabetes insipidus10.0OXT, PRL
40antisocial personality disorder10.0SLC6A4, MAOA
41anovulation10.0PRL
42hypopituitarism10.0PRL, CRH
43hypothalamic disease10.0CRH, PRL
44acth-secreting pituitary adenoma10.0PRL, CRH
45tuberculosis10.0TPO
46nelson syndrome10.0PRL, CRH
47polycystic ovary syndrome10.0CRH, PRL
48panhypopituitarism10.0PRL
49sheehan syndrome10.0PRL, CRH
50neurogenic diabetes insipidus10.0OXT, PRL

Graphical network of the top 20 diseases related to Postpartum Depression:



Diseases related to postpartum depression

Clinical Features for Postpartum Depression

Drugs & Therapeutics for Postpartum Depression

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Postpartum Depression

Drug clinical trials:

Search ClinicalTrials for Postpartum Depression

Search NIH Clinical Center for Postpartum Depression

Search CenterWatch for Postpartum Depression

Genetic Tests for Postpartum Depression

Anatomical Context for Postpartum Depression

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Postpartum Depression:

33
Cortex, Thyroid, T cells, Prefrontal cortex, Olfactory bulb, Amygdala, Fetal thyroid

Animal Models for Postpartum Depression or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Postpartum Depression:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.6CALCA, CRH, PRL, OXT, PNOC, SLC6A4
2MP:00036316.9COMT, BDNF, CALCA, HTR1A, CRH, PRL
3MP:00053766.7COMT, BDNF, CALCA, HTR1A, CRH, PRL
4MP:00053866.7SLC6A4, COMT, BDNF, CALCA, HTR1A, CRH

Publications for Postpartum Depression

Sources:
51PubMed
See all sources

Articles related to Postpartum Depression:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Preventing postpartum depression: a meta-analytic review. (24211712)
2013
2
Immigrant women's experiences of postpartum depression in Canada: a protocol for systematic review using a narrative synthesis. (23965183)
2013
3
Postpartum depression: psychoneuroimmunological underpinnings and treatment. (23459664)
2013
4
The effect of interpersonal psychotherapy on marriage adaptive and postpartum depression in isfahan. (23776734)
2013
5
An exploratory analysis of intimate partner violence and postpartum depression in an impoverished urban population. (23581837)
2013
6
Chronic perinatal pain as a risk factor for postpartum depression symptoms in Canadian women. (24183178)
2013
7
Postpartum depression: low-income women have specific needs. (24279069)
2013
8
Breastfeeding is negatively affected by prenatal depression and reduces postpartum depression. (23822932)
2013
9
Postpartum Depression and HIV Infection among Women in Malawi. (24189149)
2013
10
Postpartum Depression in Mothers of Infants in Neonatal Intensive Care Unit: Risk Factors and Management Strategies. (23918522)
2013
11
Treating postpartum depression and anxiety naturally. (22694865)
2012
12
Postpartum depression: is mode of delivery a risk factor? (23304542)
2012
13
Acute administration of Zn, Mg, and thiamine improves postpartum depression conditions in mice. (22519381)
2012
14
The effect of sertraline add-on to brief dynamic psychotherapy for the treatment of postpartum depression: a randomized, double-blind, placebo-controlled study. (22401479)
2012
15
Australian midwives' awareness and management of antenatal and postpartum depression. (21459691)
2012
16
Perfectionism dimensions in major postpartum depression. (21930303)
2012
17
Social support and online postpartum depression discussion groups: a content analysis. (22019021)
2012
18
Screening for postpartum depression among low-income mothers using an interactive voice response system. (21584791)
2012
19
Psychometric assessment of the Correa-Barrick Postpartum Depression Scale. (22658340)
2012
20
Postpartum depression screening: a comment on Leung et al. (22286557)
2012
21
The evaluation of emotional facial expressions in early postpartum depression mood: a difference between adult and baby faces? (20667418)
2011
22
Postpartum depression: an essential overview for the practitioner. (21206417)
2011
23
Postpartum depression among White, African American, and Hispanic low-income mothers in rural southeastern North Carolina. (21279889)
2011
24
Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression. (21562482)
2011
25
Factors associated with postpartum depression in Chilean women. (21919629)
2011
26
N-3 (omega-3) Fatty acids in postpartum depression: implications for prevention and treatment. (21151517)
2011
27
Gender differences in postpartum depression: a longitudinal cohort study. (20515899)
2011
28
Should postpartum depression screening policies be reevaluated? (21653986)
2011
29
An exploratory study of postpartum depression and vitamin d. (21659271)
2010
30
Blood mononuclear cell gene expression signature of postpartum depression. (19581911)
2010
31
Prevalence and risk factors for postpartum depression among women with preterm and low-birth-weight infants: a systematic review. (20121831)
2010
32
Intimate partner violence as a risk factor for postpartum depression among Canadian women in the Maternity Experience Survey. (20609336)
2010
33
Prevalence and correlates of posttraumatic stress and postpartum depression in parents of infants in the Neonatal Intensive Care Unit (NICU). (20632076)
2010
34
Prenatal family support, postnatal family support and postpartum depression. (20716261)
2010
35
Bottle feeding simulates child loss: postpartum depression and evolutionary medicine. (19666213)
2010
36
Assessment and treatment of bipolar II postpartum depression: a review. (19837461)
2010
37
Fish and long-chain n-3 polyunsaturated fatty acid intakes during pregnancy and risk of postpartum depression: a prospective study based on a large national birth cohort. (19474139)
2009
38
Differentiation and clinical implications of postpartum depression and postpartum psychosis. (19538615)
2009
39
Prevalence of postpartum depression in two municipalities in Norway. (19490523)
2009
40
Fetal sex, social support, and postpartum depression. (19961663)
2009
41
Spousal military deployment as a risk factor for postpartum depression. (19097519)
2008
42
Sleep quality in women with and without postpartum depression. (19012723)
2008
43
Postpartum depression in a military sample. (19055183)
2008
44
Understanding the pathophysiology of postpartum depression: implications for the development of novel treatments. (18667144)
2008
45
Postpartum depression among Pakistani women in Norway: prevalence and risk factors. (18846480)
2008
46
Dietary glycemic index and load and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study. (18192024)
2008
47
A multirisk approach to predicting chronicity of postpartum depression symptoms. (18729148)
2008
48
Clinical applications of anxiety, social support, stressors, and self-esteem measured during pregnancy and postpartum for screening postpartum depression in Thai women. (17578363)
2007
49
Postpartum depression in adolescent mothers: an integrative review of the literature. (17825726)
2007
50
Hormonal aspects of postpartum depression. (9802121)
1998

Genetic Variations for Postpartum Depression

Expression for genes affiliated with Postpartum Depression

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Postpartum Depression

Search GEO for disease gene expression data for Postpartum Depression.

Pathways for genes affiliated with Postpartum Depression

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 50PharmGKB, 30KEGG
See all sources

Compounds for genes affiliated with Postpartum Depression

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Postpartum Depression according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1estrogen4510.1PNOC, SLC6A4
2carbon-11459.9HTR1A, MAOA, SLC6A4
3p-chloroamphetamine459.9SLC6A4, MAOA, HTR1A
4m-chlorophenylpiperazine459.9HTR1A, PRL, SLC6A4
5mcpp459.8HTR1A, PRL, SLC6A4
6rizatriptan45 29 1111.7CALCA, HTR1A, MAOA
75-hydroxytryptophan459.7CRH, HTR1A, PRL, SLC6A4
8fenfluramine29 45 1111.7SLC6A4, HTR1A, CRH, PRL
9mdma459.7MAOA, SLC6A4, PRL, HTR1A
10pindolol45 29 1111.6HTR1A, PRL, SLC6A4
11fluvoxamine45 50 1111.5BDNF, HTR1A, MAOA, SLC6A4
12forskolin45 50 1111.5PNOC, CRH, CALCA
13clomipramine45 50 1111.5HTR1A, CRH, PRL, SLC6A4, MAOA
14pramipexole45 50 29 1112.4HTR1A, BDNF, COMT, PRL
15desipramine45 50 1111.3SLC6A4, MAOA, CRH, HTR1A, BDNF
16citalopram50 45 11 2412.3MAOA, PRL, HTR1A, SLC6A4, BDNF
17methamphetamine45 50 1111.3BDNF, SLC6A4, COMT, MAOA
18ipsapirone45 2910.3OXT, PRL, HTR1A
19apomorphine45 29 1111.2OXT, HTR1A, COMT, PRL
20maoa459.2MAOA, COMT, SLC6A4, BDNF, HTR1A
21risperidone29 45 50 60 11 2414.2PRL, HTR1A, COMT, SLC6A4, BDNF
22mptp459.2MAOA, COMT, BDNF, SLC6A4
23clozapine45 29 50 1112.1SLC6A4, PRL, HTR1A, COMT, BDNF
24levodopa45 1110.1MAOA, COMT, BDNF, HTR1A, PRL
25olanzapine50 45 29 11 2413.0HTR1A, BDNF, COMT, PRL
26naloxone45 50 29 1112.0CRH, PNOC, OXT, PRL
27sertraline45 29 50 11 2413.0MAOA, DHRS9, CRH, HTR1A, SLC6A4
28mhpg459.0COMT, BDNF, CRH, PRL, MAOA, SLC6A4
29homovanillic acid45 2410.0SLC6A4, MAOA, PRL, CRH, BDNF, COMT
30nmda45 299.9COMT, HTR1A, BDNF, MAOA, PNOC
31capsaicin45 299.9PNOC, CRH, MAOA, BDNF, CALCA
32imipramine45 50 29 11 2412.9SLC6A4, BDNF, HTR1A, MAOA
33opiate458.8PRL, OXT, CRH, SLC6A4, PNOC
34nicotine45 50 29 1111.8MAOA, OXT, SLC6A4, COMT, CRH
35thyroxine45 249.8TPO, CALCA, CRH, PRL, OXT
36choline45 11 2410.7COMT, BDNF, OXT, MAOA, SLC6A4
37cocaine45 119.7COMT, BDNF, SLC6A4, PNOC, PRL, CRH
38acth458.6PRL, HTR1A, BDNF, CRH, TPO, OXT
39acetylcholine45 50 29 11 2412.5CALCA, HTR1A, PNOC, TPO, BDNF, CRH
405-hydroxytryptamine458.2COMT, PNOC, MAOA, PRL, CRH, HTR1A
41paroxetine45 50 29 1111.1MAOA, DHRS9, SLC6A4, PRL, HTR1A, BDNF
42epinephrine45 11 249.9COMT, SLC6A4, MAOA, OXT, PRL, CRH
43gaba457.6MAOA, PNOC, OXT, CRH, BDNF, SLC6A4
44fluoxetine50 45 29 1110.6HTR1A, OXT, DHRS9, SLC6A4, MAOA, PRL
45corticosterone45 60 249.5BDNF, CALCA, CRH, SLC6A4, DHRS9, OXT
46steroid457.4PRL, TPO, PNOC, DHRS9, OXT, BDNF
47glutamate457.3OXT, SLC6A4, COMT, BDNF, TPO, PNOC
48norepinephrine45 11 249.1BDNF, SLC6A4, PNOC, MAOA, OXT, PRL
49dopamine45 29 11 2410.1SLC6A4, BDNF, CALCA, COMT, HTR1A, CRH
50testosterone45 60 11 249.7SLC6A4, CALCA, PRL, BDNF, COMT, OXT

GO Terms for genes affiliated with Postpartum Depression

Sources:
16Gene Ontology
See all sources

Cellular components related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9PNOC, OXT, PRL, CRH, CALCA, BDNF

Biological processes related to Postpartum Depression according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:01406210.2HTR1A, CRH
2dopamine catabolic processGO:04242010.1MAOA, COMT
3parturitionGO:00756710.1CRH, PRL
4neurotransmitter catabolic processGO:04213510.0MAOA, COMT
5vasoconstrictionGO:0423109.9SLC6A4, HTR1A
6neurotransmitter biosynthetic processGO:0421369.9MAOA, COMT
7response to etherGO:0454729.9OXT, CRH
8sperm ejaculationGO:0427139.8SLC6A4, OXT
9response to painGO:0482659.8CRH, CALCA, COMT
10feeding behaviorGO:0076319.7CRH, CALCA, BDNF
11positive regulation of ossificationGO:0457789.6OXT, CALCA
12response to estradiol stimulusGO:0323559.5PRL, OXT, SLC6A4
13negative regulation of blood pressureGO:0457769.5CALCA, CRH, OXT
14response to drugGO:0424939.5COMT, CRH, PRL, SLC6A4
15behavioral fear responseGO:0016629.5HTR1A, BDNF
16regulation of heart rateGO:0020279.4OXT, CALCA
17positive regulation of synapse assemblyGO:0519659.3BDNF, OXT
18female pregnancyGO:0075659.3OXT, PRL, CRH, COMT
19synaptic transmissionGO:0072689.2COMT, CRH, MAOA, PNOC

Molecular functions related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.7PNOC, CRH
2hormone activityGO:0051799.2PRL, CRH, CALCA

Products for genes affiliated with Postpartum Depression

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Sources for Postpartum Depression

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet