MCID: PST021
MIFTS: 54

Postpartum Depression malady

Summaries for Postpartum Depression

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Many women have the baby blues after childbirth. if you have the baby blues, you may have mood swings, feel sad, anxious or overwhelmed, have crying spells, lose your appetite, or have trouble sleeping. the baby blues most often go away within a few days or a week. the symptoms are not severe and do not need treatment. the symptoms of postpartum depression last longer and are more severe. you may also feel hopeless and worthless, and lose interest in the baby. you may have thoughts of hurting yourself or the baby. very rarely, new mothers develop something even more serious. they may have hallucinations or try to hurt themselves or the baby. they need to get treatment right away, often in the hospital. postpartum depression can begin anytime within the first year after childbirth. the cause is not known. hormonal and physical changes after birth and the stress of caring for a new baby may play a role. women who have had depression are at higher risk. if you think you have postpartum depression, tell your health care provider. medicines, including antidepressants and talk therapy can help you get well. dept. of health and human services office on women's health

MalaCards: Postpartum Depression, also known as maternity blues, is related to obesity and anxiety disorder. An important gene associated with Postpartum Depression is CRH (corticotropin releasing hormone), and among its related pathways are phenylalanine utilization and Tyrosine metabolism p.1 (dopamine) . The compounds estrogen and carbon-11 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, amygdala and testes, and related mouse phenotypes are integument and nervous system.

Disease Ontology:8 An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth.

Wikipedia:63 Postpartum depression (PPD), also called postnatal depression, is a type of clinical depression which... more...

Aliases & Classifications for Postpartum Depression

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Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

postpartum depression 8 33
maternity blues 8 60
depression, postpartum 60
depression postpartum 44
postnatal depression 8


External Ids:

Disease Ontology8 DOID:9478
MeSH34 D019052

Related Diseases for Postpartum Depression

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Postpartum Depression via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.3MAOA, CRH, HTR1A, COMT
2anxiety disorder30.2BDNF, CRH, MAOA, SLC6A4
3generalized anxiety disorder30.0SLC6A4, HTR1A
4substance abuse30.0CRH, SLC6A4
5neuroblastoma30.0BDNF
6personality disorder30.0MAOA, SLC6A4
7infertility30.0TPO, PRL
8conduct disorder30.0SLC6A4, MAOA, COMT
9thyroiditis30.0TPO, CALCA
10bipolar disorder30.0BDNF, HTR1A, SLC6A4
11bulimia nervosa29.9COMT, BDNF, MAOA, SLC6A4
12migraine29.9COMT, CALCA, HTR1A, MAOA, PNOC, SLC6A4
13dementia29.9TPO, MAOA, HTR1A, BDNF, COMT
14mood disorder29.9COMT, BDNF, HTR1A, CRH, MAOA, SLC6A4
15mental depression10.4
16major depressive disorder10.1
17olfactory neuroblastoma10.0
18tropical spastic paraparesis10.0
19multiple personality disorder10.0
20frontotemporal dementia10.0
21trigeminal neuralgia10.0
22osteoporosis10.0
23diarrhea10.0
24factitious disorder10.0
25meningioma10.0
26sleep disorder10.0
27wilson disease10.0PNOC
28cocaine dependence10.0SLC6A4
29nicotine dependence10.0SLC6A4
30cocaine abuse10.0SLC6A4
31hypoadrenalism10.0CRH
32fragile x syndrome10.0SLC6A4
33paranoid schizophrenia10.0COMT
34endometriosis10.0COMT
35hepatitis10.0COMT
36acute myocardial infarction10.0SLC6A4
37irritable bowel syndrome10.0SLC6A4, CRH
38melancholia10.0MAOA, CRH
39essential hypertension10.0COMT
40premature ejaculation10.0HTR1A, SLC6A4
41serotonin syndrome10.0HTR1A, MAOA
42diabetes mellitus10.0CALCA
43sudden infant death syndrome10.0SLC6A4, HTR1A
44hyperthyroxinemia10.0TPO
45amenorrhea10.0PRL, CRH
46diabetes insipidus10.0OXT, PRL
47antisocial personality disorder10.0SLC6A4, MAOA
48hypopituitarism10.0PRL, CRH
49anovulation10.0PRL
50hypothalamic disease10.0CRH, PRL

Graphical network of the top 20 diseases related to Postpartum Depression:



Diseases related to postpartum depression

Clinical Features for Postpartum Depression

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Drugs & Therapeutics for Postpartum Depression

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Postpartum Depression

Drug clinical trials:

Search ClinicalTrials for Postpartum Depression

Search NIH Clinical Center for Postpartum Depression

Search CenterWatch for Postpartum Depression

Genetic Tests for Postpartum Depression

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Anatomical Context for Postpartum Depression

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Sources:
32MalaCards
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MalaCards organs/tissues related to Postpartum Depression:

32
Thyroid, Amygdala, Testes, Cortex, Prefrontal cortex

Animal Models for Postpartum Depression or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Postpartum Depression:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107717.6CALCA, CRH, PRL, OXT, PNOC, SLC6A4
2MP:00036316.9COMT, BDNF, CALCA, HTR1A, CRH, PRL
3MP:00053766.7COMT, BDNF, CALCA, HTR1A, CRH, PRL
4MP:00053866.7SLC6A4, COMT, BDNF, CALCA, HTR1A, CRH

Publications for Postpartum Depression

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Sources:
50PubMed
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Articles related to Postpartum Depression:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
A multiple-baseline study of the effects associated with metacognitive therapy in postpartum depression. (23374492)
2013
2
Preventing postpartum depression: a meta-analytic review. (24211712)
2013
3
Immigrant women's experiences of postpartum depression in Canada: a protocol for systematic review using a narrative synthesis. (23965183)
2013
4
Postpartum depression: psychoneuroimmunological underpinnings and treatment. (23459664)
2013
5
A prospective study of diagnostic conversion of major depressive disorder to bipolar disorder in pregnancy and postpartum. (24127853)
2013
6
Predictors of postpartum depression: Prospective study of 264 women followed during pregnancy and postpartum. (24370337)
2013
7
Short forms of the postpartum depression screening scale: as accurate as the original form. (23255075)
2013
8
A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression. (24173623)
2013
9
The interrelationships among acculturation, social support, and postpartum depression symptoms among marriage-based immigrant women in Taiwan: a cohort study. (22865022)
2013
10
Antenatal maternal mental health as determinant of postpartum depression in a population based mother-child cohort (Rhea Study) in Crete, Greece. (23963406)
2013
11
Is positive affect in pregnancy protective of postpartum depression? (23567594)
2013
12
Using critical ethnography to explore issues among immigrant and refugee women seeking help for postpartum depression. (23146007)
2012
13
The effect of sertraline add-on to brief dynamic psychotherapy for the treatment of postpartum depression: a randomized, double-blind, placebo-controlled study. (22401479)
2012
14
Australian midwives' awareness and management of antenatal and postpartum depression. (21459691)
2012
15
Perfectionism dimensions in major postpartum depression. (21930303)
2012
16
Social support and online postpartum depression discussion groups: a content analysis. (22019021)
2012
17
Interpersonal psychotherapy for postpartum depression. (22473762)
2012
18
The relationship between postpartum depression and breastfeeding. (22978082)
2012
19
A study of postpartum depression in a fast developing country: prevalence and related factors. (23094465)
2012
20
Postpartum depression: the distribution of severity in a community sample. (21713455)
2011
21
Risk factors for sub-clinical and major postpartum depression among a community cohort of Canadian women. (18256913)
2011
22
Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression. (21562482)
2011
23
Factors associated with postpartum depression in Chilean women. (21919629)
2011
24
Elevated corticotropin releasing hormone (CRH) during pregnancy and risk of postpartum depression (PPD). (20943787)
2011
25
Is insomnia in late pregnancy a risk factor for postpartum depression/depressive symptomatology? (20638730)
2011
26
Potential diagnostic markers for postpartum depression point out to altered immune signaling. (20029403)
2010
27
Blood mononuclear cell gene expression signature of postpartum depression. (19581911)
2010
28
Effect of depot medroxyprogesterone acetate on postpartum depression. (20654759)
2010
29
Prevalence and correlates of posttraumatic stress and postpartum depression in parents of infants in the Neonatal Intensive Care Unit (NICU). (20632076)
2010
30
Prenatal family support, postnatal family support and postpartum depression. (20716261)
2010
31
Postpartum depression: a disorder in search of a definition. (20127453)
2010
32
The Postpartum Depression Screening Scale-Spanish version: examining the psychometric properties and prevalence of risk for postpartum depression. (19449208)
2010
33
A systematic review of home-based interventions to prevent and treat postpartum depression. (19137448)
2009
34
Training health professionals to detect and support mothers at risk of postpartum depression or infant abuse in the community: a cross-sectional and a before and after study. (20103940)
2009
35
Fish and long-chain n-3 polyunsaturated fatty acid intakes during pregnancy and risk of postpartum depression: a prospective study based on a large national birth cohort. (19474139)
2009
36
Differentiation and clinical implications of postpartum depression and postpartum psychosis. (19538615)
2009
37
Prevalence of postpartum depression in two municipalities in Norway. (19490523)
2009
38
An Ayurvedic approach to postpartum depression. (19574756)
2009
39
The impact of cultural factors upon postpartum depression: a literature review. (18569045)
2008
40
Sleep quality in women with and without postpartum depression. (19012723)
2008
41
Understanding the pathophysiology of postpartum depression: implications for the development of novel treatments. (18667144)
2008
42
Postpartum depression among Pakistani women in Norway: prevalence and risk factors. (18846480)
2008
43
Dietary glycemic index and load and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study. (18192024)
2008
44
Healthcare worker's perceptions of barriers to care by immigrant women with postpartum depression: an exploratory qualitative study. (17497307)
2007
45
Clinical applications of anxiety, social support, stressors, and self-esteem measured during pregnancy and postpartum for screening postpartum depression in Thai women. (17578363)
2007
46
Postpartum depression in adolescent mothers: an integrative review of the literature. (17825726)
2007
47
Impact of defense style on brief psychotherapy of postpartum depression. (18043530)
2007
48
Canadian mothers' perceived support needs during postpartum depression. (17880314)
2007
49
CYP2D6 genotypes and depressive symptoms during late pregnancy and postpartum. (14985156)
2004
50
Hormonal aspects of postpartum depression. (9802121)
1998

Genetic Variations for Postpartum Depression

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Expression for genes affiliated with Postpartum Depression

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Postpartum Depression

Search GEO for disease gene expression data for Postpartum Depression.

Pathways for genes affiliated with Postpartum Depression

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 49PharmGKB, 29KEGG
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Compounds for genes affiliated with Postpartum Depression

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 59Tocris Bioscience
See all sources

Compounds related to Postpartum Depression according to GeneCards/GeneDecks:

(show top 50)    (show all 198)
idCompoundScoreTop Affiliating Genes
1estrogen4410.1PNOC, SLC6A4
2carbon-11449.9HTR1A, MAOA, SLC6A4
3p-chloroamphetamine449.9SLC6A4, MAOA, HTR1A
4m-chlorophenylpiperazine449.9HTR1A, PRL, SLC6A4
5mcpp449.8HTR1A, PRL, SLC6A4
6rizatriptan44 28 1111.7CALCA, HTR1A, MAOA
75-hydroxytryptophan449.7CRH, HTR1A, PRL, SLC6A4
8fenfluramine28 44 1111.7SLC6A4, HTR1A, CRH, PRL
9mdma449.7MAOA, SLC6A4, PRL, HTR1A
10pindolol44 28 1111.6HTR1A, PRL, SLC6A4
11fluvoxamine44 49 1111.5BDNF, HTR1A, MAOA, SLC6A4
12forskolin44 49 1111.5PNOC, CRH, CALCA
13clomipramine44 49 1111.5HTR1A, CRH, PRL, SLC6A4, MAOA
14pramipexole44 49 28 1112.4HTR1A, BDNF, COMT, PRL
15desipramine44 49 1111.3SLC6A4, MAOA, CRH, HTR1A, BDNF
16citalopram49 44 11 2412.3MAOA, PRL, HTR1A, SLC6A4, BDNF
17methamphetamine44 49 1111.3BDNF, SLC6A4, COMT, MAOA
18ipsapirone44 2810.3OXT, PRL, HTR1A
19apomorphine44 28 1111.2OXT, HTR1A, COMT, PRL
20maoa449.2MAOA, COMT, SLC6A4, BDNF, HTR1A
21risperidone28 44 49 59 11 2414.2PRL, HTR1A, COMT, SLC6A4, BDNF
22mptp449.2MAOA, COMT, BDNF, SLC6A4
23clozapine44 28 49 1112.1SLC6A4, PRL, HTR1A, COMT, BDNF
24levodopa44 1110.1MAOA, COMT, BDNF, HTR1A, PRL
25olanzapine49 44 28 11 2413.0HTR1A, BDNF, COMT, PRL
26naloxone44 49 28 1112.0CRH, PNOC, OXT, PRL
27sertraline44 28 49 11 2413.0MAOA, DHRS9, CRH, HTR1A, SLC6A4
28mhpg449.0COMT, BDNF, CRH, PRL, MAOA, SLC6A4
29homovanillic acid44 2410.0SLC6A4, MAOA, PRL, CRH, BDNF, COMT
30nmda44 289.9COMT, HTR1A, BDNF, MAOA, PNOC
31capsaicin44 289.9PNOC, CRH, MAOA, BDNF, CALCA
32imipramine44 49 28 11 2412.9SLC6A4, BDNF, HTR1A, MAOA
33opiate448.8PRL, OXT, CRH, SLC6A4, PNOC
34nicotine44 49 28 1111.8MAOA, OXT, SLC6A4, COMT, CRH
35thyroxine44 249.8TPO, CALCA, CRH, PRL, OXT
36choline44 11 2410.7COMT, BDNF, OXT, MAOA, SLC6A4
37cocaine44 119.7COMT, BDNF, SLC6A4, PNOC, PRL, CRH
38acth448.6PRL, HTR1A, BDNF, CRH, TPO, OXT
39acetylcholine44 49 28 11 2412.5CALCA, HTR1A, PNOC, TPO, BDNF, CRH
405-hydroxytryptamine448.2COMT, PNOC, MAOA, PRL, CRH, HTR1A
41paroxetine44 49 28 1111.1MAOA, DHRS9, SLC6A4, PRL, HTR1A, BDNF
42epinephrine44 11 249.9COMT, SLC6A4, MAOA, OXT, PRL, CRH
43gaba447.6MAOA, PNOC, OXT, CRH, BDNF, SLC6A4
44fluoxetine49 44 28 1110.6HTR1A, OXT, DHRS9, SLC6A4, MAOA, PRL
45corticosterone44 59 249.5BDNF, CALCA, CRH, SLC6A4, DHRS9, OXT
46steroid447.4PRL, TPO, PNOC, DHRS9, OXT, BDNF
47glutamate447.3OXT, SLC6A4, COMT, BDNF, TPO, PNOC
48norepinephrine44 11 249.1BDNF, SLC6A4, PNOC, MAOA, OXT, PRL
49dopamine44 28 11 2410.1SLC6A4, BDNF, CALCA, COMT, HTR1A, CRH
50testosterone44 59 11 249.7SLC6A4, CALCA, PRL, BDNF, COMT, OXT

GO Terms for genes affiliated with Postpartum Depression

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Sources:
16Gene Ontology
See all sources

Cellular components related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9PNOC, OXT, PRL, CRH, CALCA, BDNF

Biological processes related to Postpartum Depression according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:01406210.2HTR1A, CRH
2dopamine catabolic processGO:04242010.1MAOA, COMT
3parturitionGO:00756710.1CRH, PRL
4neurotransmitter catabolic processGO:04213510.0MAOA, COMT
5vasoconstrictionGO:0423109.9SLC6A4, HTR1A
6neurotransmitter biosynthetic processGO:0421369.9MAOA, COMT
7response to etherGO:0454729.9OXT, CRH
8sperm ejaculationGO:0427139.8SLC6A4, OXT
9response to painGO:0482659.8CRH, CALCA, COMT
10feeding behaviorGO:0076319.7CRH, CALCA, BDNF
11positive regulation of ossificationGO:0457789.6OXT, CALCA
12response to estradiol stimulusGO:0323559.5PRL, OXT, SLC6A4
13negative regulation of blood pressureGO:0457769.5CALCA, CRH, OXT
14response to drugGO:0424939.5COMT, CRH, PRL, SLC6A4
15behavioral fear responseGO:0016629.5HTR1A, BDNF
16regulation of heart rateGO:0020279.4OXT, CALCA
17positive regulation of synapse assemblyGO:0519659.3BDNF, OXT
18female pregnancyGO:0075659.3OXT, PRL, CRH, COMT
19synaptic transmissionGO:0072689.2COMT, CRH, MAOA, PNOC

Molecular functions related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.7PNOC, CRH
2hormone activityGO:0051799.2PRL, CRH, CALCA

Products for genes affiliated with Postpartum Depression

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  • Antibodies
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Sources for Postpartum Depression

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet