MCID: PST021
MIFTS: 56

Postpartum Depression malady

Summaries for Postpartum Depression

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MedlinePlus:34 Many women have the baby blues after childbirth. if you have the baby blues, you may have mood swings, feel sad, anxious or overwhelmed, have crying spells, lose your appetite, or have trouble sleeping. the baby blues most often go away within a few days or a week. the symptoms are not severe and do not need treatment. the symptoms of postpartum depression last longer and are more severe. you may also feel hopeless and worthless, and lose interest in the baby. you may have thoughts of hurting yourself or the baby. very rarely, new mothers develop something even more serious. they may have hallucinations or try to hurt themselves or the baby. they need to get treatment right away, often in the hospital. postpartum depression can begin anytime within the first year after childbirth. the cause is not known. hormonal and physical changes after birth and the stress of caring for a new baby may play a role. women who have had depression are at higher risk. if you think you have postpartum depression, tell your health care provider. medicines, including antidepressants and talk therapy can help you get well. dept. of health and human services office on women's health

MalaCards based summary: Postpartum Depression, also known as maternity blues, is related to obesity and generalized anxiety disorder. An important gene associated with Postpartum Depression is CRH (corticotropin releasing hormone), and among its related pathways are Dopamine metabolism and Biogenic Amine Synthesis. The compounds carbon-11 and p-chloroamphetamine have been mentioned in the context of this disorder. Affiliated tissues include amygdala, cortex and thyroid, and related mouse phenotypes are endocrine/exocrine gland and cardiovascular system.

Disease Ontology:10 An endogenous depression that involves intense, sustained and sometimes disabling depression experienced by women after giving birth.

Wikipedia:65 Postpartum depression (PPD), also called postnatal depression, is a type of clinical depression which... more...

Aliases & Classifications for Postpartum Depression

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Postpartum Depression, Aliases & Descriptions:

Name: Postpartum Depression 10 34
Maternity Blues 10 62
Depression, Postpartum 62
 
Depression Postpartum 45
Postnatal Depression 10


External Ids:

Disease Ontology10 DOID:9478
MeSH35 D019052

Related Diseases for Postpartum Depression

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Diseases related to Postpartum Depression via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1obesity30.4MAOA, HTR1A, COMT, CRH
2generalized anxiety disorder30.3HTR1A, SLC6A4
3infertility30.3PRL, ESR1, TPO
4personality disorder30.1SLC6A4, MAOA
5bipolar disorder30.1SLC6A4, BDNF, HTR1A
6osteoporosis30.1CALCA, ESR1
7conduct disorder30.1SLC6A4, MAOA, COMT
8anxiety disorder30.1BDNF, SLC6A4, CRH, MAOA
9thyroiditis30.1CALCA, TPO
10bulimia nervosa30.0MAOA, COMT, BDNF, SLC6A4
11mood disorder30.0COMT, MAOA, BDNF, SLC6A4, HTR1A, CRH
12migraine30.0HTR1A, COMT, MAOA, CALCA, SLC6A4, PNOC
13dementia30.0TPO, HTR1A, COMT, MAOA, BDNF
14blindness10.3
15hypoadrenalism10.1CRH
16paranoid schizophrenia10.1COMT
17pituitary carcinoma10.1PRL
18pervasive developmental disorder10.1SLC6A4
19breast fibroadenoma10.0ESR1
20breast disease10.0ESR1
21ovarian disease10.0ESR1
22melancholia10.0CRH, MAOA
23serotonin syndrome10.0HTR1A, MAOA
24neuroblastoma10.0
25tropical spastic paraparesis10.0
26olfactory neuroblastoma10.0
27multiple personality disorder10.0
28trigeminal neuralgia10.0
29diarrhea10.0
30factitious disorder10.0
31sleep disorder10.0
32spastic paraparesis10.0
33spasticity10.0
34sheehan syndrome10.0PRL, CRH
35hypothalamic disease10.0PRL, CRH
36pituitary-dependent cushing's disease10.0CRH, PRL
37nelson syndrome10.0CRH, PRL
38substance abuse10.0CRH, SLC6A4
39diabetes insipidus, neurohypophyseal10.0OXT, PRL
40premature ejaculation10.0SLC6A4, HTR1A
41agoraphobia10.0HTR1A, MAOA
42pituitary gland disease10.0CRH, PRL
43acth deficiency10.0CRH, PRL
44diabetes insipidus10.0PRL, OXT
45amenorrhea10.0CRH, PRL
46antisocial personality disorder10.0SLC6A4, MAOA
47adrenal gland hyperfunction10.0PRL, CRH
48growth hormone deficiency10.0CRH, PRL
49hyperprolactinemia10.0CRH, PRL
50cushing's syndrome10.0CRH, PRL

Graphical network of the top 20 diseases related to Postpartum Depression:



Diseases related to postpartum depression

Symptoms for Postpartum Depression

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Drugs & Therapeutics for Postpartum Depression

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Drug clinical trials:

Search ClinicalTrials for Postpartum Depression

Search NIH Clinical Center for Postpartum Depression

Genetic Tests for Postpartum Depression

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Anatomical Context for Postpartum Depression

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MalaCards organs/tissues related to Postpartum Depression:

33
Amygdala, Cortex, Thyroid, Testes, Prefrontal cortex

Animal Models for Postpartum Depression or affiliated genes

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MGI Mouse Phenotypes related to Postpartum Depression:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053797.5TPO, ESR1, PRL, OXT, CRH, SLC6A4
2MP:00053857.5ESR1, OXT, HTR1A, COMT, MAOA, CALCA
3MP:00107687.3ESR1, OXT, HTR1A, CALCA, BDNF, SLC6A4
4MP:00107716.7PNOC, ESR1, PRL, OXT, CALCA, CRH
5MP:00036316.6HTR1A, OXT, PRL, ESR1, COMT, MAOA
6MP:00053766.2OXT, PRL, ESR1, TPO, HTR1A, COMT
7MP:00053865.9SLC6A4, PNOC, ESR1, PRL, OXT, HTR1A

Publications for Postpartum Depression

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Articles related to Postpartum Depression:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Correlation Between the Great East Japan Earthquake and Postpartum Depression: A Study in Miyako, Iwate, Japan. (25896395)
2015
2
The Relationship Between Postpartum Depression and Perinatal Cigarette Smoking: An Analysis of PRAMS Data. (25841705)
2015
3
Postpartum Anxiety in a Cohort of Women from the General Population: Risk Factors and Association with Depression during Last Week of Pregnancy, Postpartum Depression and Postpartum PTSD. (25372562)
2014
4
Adult physical, sexual, and emotional abuse and postpartum depression, a population based, prospective study of 53,065 women in the Norwegian Mother and Child Cohort Study. (25199411)
2014
5
Surveys of postpartum depression in Miyagi, Japan, after the Great East Japan Earthquake. (25204487)
2014
6
Self-harm in postpartum depression and referrals to a perinatal mental health team: an audit study. (23462983)
2013
7
A multiple-baseline study of the effects associated with metacognitive therapy in postpartum depression. (23374492)
2013
8
Insomnia treatment in the third trimester of pregnancy reduces postpartum depression symptoms: a randomized clinical trial. (23993464)
2013
9
Postpartum depression among Thai women: a national survey. (24319843)
2013
10
Using short-term group psychotherapy as an evidence-based intervention for first-time mothers at risk for postpartum depression. (23819670)
2013
11
Web recruitment and internet use and preferences reported by women with postpartum depression after pregnancy complications. (23540519)
2013
12
Testing of a prototype Web based intervention for adolescent mothers on postpartum depression. (23473677)
2013
13
Postpartum depression in adolescent and adult mothers: comparing prenatal risk factors and predictive models. (22886352)
2013
14
Treating postpartum depression and anxiety naturally. (22694865)
2012
15
Risk factors for postpartum depression among abused and nonabused women. (23063016)
2012
16
Increased glutamate levels in the medial prefrontal cortex in patients with postpartum depression. (22805604)
2012
17
Postpartum depression: is mode of delivery a risk factor? (23304542)
2012
18
Using critical ethnography to explore issues among immigrant and refugee women seeking help for postpartum depression. (23146007)
2012
19
Reliability of the postpartum depression screening scale in the neonatal intensive care unit. (22960585)
2012
20
A frontotemporal dementia-like syndrome mimicking postpartum depression detected by 18F fluorodeoxyglucose positron emission tomography. (22889797)
2012
21
Postpartum depression is a family affair: addressing the impact on mothers, fathers, and children. (22757597)
2012
22
Acute administration of Zn, Mg, and thiamine improves postpartum depression conditions in mice. (22519381)
2012
23
Screening for postpartum depression in a pediatric emergency department. (21878826)
2011
24
Chronicity and severity of maternal postpartum depression and infant sleep disorders: a population-based cohort study in southern Brazil. (21211848)
2011
25
The evaluation of emotional facial expressions in early postpartum depression mood: a difference between adult and baby faces? (20667418)
2011
26
Chinese version of the Postpartum Depression Screening Scale: translation and validation. (21691238)
2011
27
Postpartum depression: the distribution of severity in a community sample. (21713455)
2011
28
The case for investigating postpartum depression in lesbians and bisexual women. (21521621)
2011
29
Experiences of postpartum depression among first-time mothers in mainland China. (20423413)
2010
30
Potential diagnostic markers for postpartum depression point out to altered immune signaling. (20029403)
2010
31
An exploratory study of postpartum depression and vitamin d. (21659271)
2010
32
The correlation between postpartum depression and health status. (19693658)
2010
33
Suffering in silence: a qualitative meta-data-analysis of postpartum depression. (19302513)
2009
34
A systematic review of home-based interventions to prevent and treat postpartum depression. (19137448)
2009
35
Postpartum depression and apical ballooning syndrome (takotsubo syndrome). (19772707)
2009
36
The role of traditional confinement practices in determining postpartum depression in women in Chinese cultures: a systematic review of the English language evidence. (19135261)
2009
37
Spousal military deployment as a risk factor for postpartum depression. (19097519)
2008
38
State of the Science on postpartum depression: what nurse researchers have contributed--part 1. (18327112)
2008
39
Infanticide secrets: qualitative study on postpartum depression. (19074717)
2008
40
Shifting landscapes: immigrant women and postpartum depression. (18569046)
2008
41
Treatment of postpartum depression with psychotic features in a patient with tropical spastic paraparesis. (18413682)
2008
42
Prediction of postpartum depression by sociodemographic, obstetric and psychological factors: a prospective study. (18588594)
2008
43
Identifying postpartum depression: are 3 questions as good as 10? (18762505)
2008
44
A case study of postpartum depression & altered maternal-newborn attachment. (18453907)
2008
45
The impact of cultural factors upon postpartum depression: a literature review. (18569045)
2008
46
Postpartum depression: racial differences and ethnic disparities in a tri-racial and bi-ethnic population. (17955356)
2008
47
Symptoms of postpartum depression associated with elevated levels of interleukin-1 beta during the first month postpartum. (18829596)
2008
48
Risk for postpartum depression, breastfeeding practices, and mammary gland permeability. (18281356)
2008
49
Comparing postpartum depression and major depressive disorder: issues in assessment. (17654110)
2007
50
Postpartum depression screening by family nurse practitioners. (17535342)
2007

Variations for Postpartum Depression

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Expression for genes affiliated with Postpartum Depression

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Search GEO for disease gene expression data for Postpartum Depression.

Pathways for genes affiliated with Postpartum Depression

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Pathways related to Postpartum Depression according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MAOA, COMT
2
Show member pathways
catecholamine biosynthesis38
9.9MAOA, COMT
39.9COMT, MAOA
4
Show member pathways
9.9COMT, MAOA
59.9MAOA, COMT
6
Show member pathways
Serotonin Transporter Activity38
9.8SLC6A4, MAOA
7
Show member pathways
9.5PRL, ESR1
89.5SLC6A4, MAOA, HTR1A
9
Show member pathways
phenylalanine utilization38
noradrenaline and adrenaline degradation38
phenylalanine degradation IV38
9.3MAOA, COMT, TPO
10
Show member pathways
Calcium Regulation in the Cardiac Cell38
9.2CRH, CALCA, OXT
11
Show member pathways
9.2HTR1A, COMT, MAOA, SLC6A4
129.1HTR1A, MAOA, BDNF, SLC6A4
13
Show member pathways
8.7PRL, MAOA, CALCA, CRH, BDNF
14
Show member pathways
7.8CRH, PNOC, PRL, OXT, HTR1A, CALCA
15
Show member pathways
7.2PNOC, ESR1, PRL, OXT, HTR1A, CALCA

Compounds for genes affiliated with Postpartum Depression

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Compounds related to Postpartum Depression according to GeneCards/GeneDecks:

(show top 50)    (show all 236)
idCompoundScoreTop Affiliating Genes
1carbon-11459.6SLC6A4, MAOA, HTR1A
2p-chloroamphetamine459.6HTR1A, MAOA, SLC6A4
35-hydroxytryptophan459.6CRH, HTR1A, PRL, SLC6A4
4sertraline45 30 51 26 1313.6CRH, HTR1A, MAOA, SLC6A4
5fenfluramine45 30 1311.6CRH, HTR1A, PRL, SLC6A4
6mdma459.5HTR1A, SLC6A4, MAOA, PRL
7pramipexole45 30 51 1312.5BDNF, PRL, COMT, HTR1A
8venlafaxine45 51 26 1312.4COMT, BDNF, SLC6A4, HTR1A
9rizatriptan45 30 1311.4CALCA, MAOA, HTR1A
10m-chlorophenylpiperazine459.4SLC6A4, HTR1A, PRL
11clomipramine45 51 1311.3PRL, MAOA, CRH, SLC6A4, HTR1A
12apomorphine30 45 1311.3PRL, OXT, COMT, HTR1A
13heroin45 51 1311.2COMT, CALCA, SLC6A4, BDNF
14desipramine45 51 1311.2SLC6A4, BDNF, CRH, MAOA, HTR1A
15maoa459.2BDNF, COMT, HTR1A, SLC6A4, MAOA
16fluvoxamine45 51 1311.2MAOA, BDNF, COMT, HTR1A, SLC6A4
17risperidone45 51 30 61 26 1314.2SLC6A4, HTR1A, BDNF, COMT, PRL
18levodopa45 1310.2COMT, MAOA, BDNF, PRL, HTR1A
19olanzapine45 51 30 26 1313.1PRL, HTR1A, COMT, BDNF, SLC6A4
20quetiapine45 51 30 26 1313.1SLC6A4, BDNF, PRL, HTR1A
21clozapine45 30 51 1312.1SLC6A4, BDNF, PRL, COMT, HTR1A
22mhpg458.9SLC6A4, BDNF, CRH, MAOA, COMT, PRL
23homovanillic acid45 269.9BDNF, SLC6A4, CRH, MAOA, COMT, PRL
24citalopram45 51 26 1311.9SLC6A4, CRH, BDNF, PRL, HTR1A, MAOA
25paroxetine45 51 30 1311.9BDNF, COMT, PRL, HTR1A, MAOA, SLC6A4
26methamphetamine45 51 1310.8SLC6A4, BDNF, MAOA, COMT
27choline45 26 1310.7OXT, COMT, MAOA, BDNF, SLC6A4
28nicotine45 30 51 1311.7OXT, COMT, CRH, SLC6A4, MAOA
29capsaicin45 309.6CALCA, BDNF, MAOA, CRH, PNOC
30thyroxine45 269.5TPO, CRH, OXT, PRL, CALCA
31opiate458.5SLC6A4, CRH, PNOC, PRL, OXT
32fluoxetine45 51 30 1311.4SLC6A4, BDNF, CRH, MAOA, HTR1A, OXT
33cocaine45 139.4PRL, CRH, BDNF, COMT, PNOC, SLC6A4
34gnrh458.3PRL, CRH, BDNF, SLC6A4, ESR1, OXT
35naloxone45 30 51 1311.3OXT, PNOC, ESR1, PRL, CRH
36nmda45 309.3PNOC, HTR1A, MAOA, BDNF, COMT, SLC6A4
37corticosterone45 61 2610.3HTR1A, CALCA, CRH, BDNF, PRL, SLC6A4
38estradiol45 26 1310.2BDNF, ESR1, PRL, CRH, OXT, COMT
39gaba458.1PNOC, BDNF, SLC6A4, OXT, CRH, MAOA
40acth458.1CALCA, HTR1A, TPO, OXT, PRL, BDNF
41acetylcholine45 51 30 26 1312.0CALCA, TPO, HTR1A, CRH, BDNF, PNOC
42epinephrine45 26 139.9COMT, SLC6A4, CALCA, MAOA, OXT, PRL
435-hydroxytryptamine457.8COMT, PNOC, PRL, MAOA, CALCA, CRH
44forskolin45 51 139.7BDNF, CRH, PNOC, CALCA, OXT, TPO
45steroid457.2TPO, PNOC, ESR1, PRL, OXT, CRH
46glutamate456.9OXT, SLC6A4, BDNF, CALCA, TPO, CRH
47norepinephrine45 26 138.8SLC6A4, BDNF, CRH, OXT, HTR1A, COMT
48dopamine45 30 26 139.8SLC6A4, BDNF, CRH, CALCA, COMT, HTR1A
49testosterone45 61 26 139.8MAOA, CALCA, CRH, BDNF, SLC6A4, PRL
50estrogen456.5MAOA, SLC6A4, CALCA, CRH, BDNF, OXT

GO Terms for genes affiliated with Postpartum Depression

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Cellular components related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1terminal boutonGO:00431959.5CALCA, OXT
2extracellular regionGO:00055768.2BDNF, CRH, OXT, PNOC

Biological processes related to Postpartum Depression according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1regulation of serotonin secretionGO:001406210.2HTR1A, CRH
2dopamine catabolic processGO:004242010.2MAOA, COMT
3neurotransmitter catabolic processGO:004213510.1MAOA, COMT
4neurotransmitter biosynthetic processGO:004213610.1MAOA, COMT
5vasoconstrictionGO:004231010.0SLC6A4, HTR1A
6response to etherGO:004547210.0CRH, OXT
7behavioral fear responseGO:00016629.9HTR1A, BDNF
8sperm ejaculationGO:00427139.9SLC6A4, OXT
9response to painGO:00482659.8CRH, CALCA, COMT
10positive regulation of cAMP biosynthetic processGO:00308199.8CRH, CALCA
11positive regulation of ossificationGO:00457789.7OXT, CALCA
12learning or memoryGO:00076119.7CRH, BDNF
13positive regulation of synapse assemblyGO:00519659.7OXT, BDNF
14feeding behaviorGO:00076319.7BDNF, CRH, CALCA
15negative regulation of blood pressureGO:00457769.6OXT, CALCA, CRH
16regulation of heart rateGO:00020279.6CALCA, OXT
17response to drugGO:00424939.5SLC6A4, CRH, COMT
18female pregnancyGO:00075659.4CRH, COMT, OXT, PRL
19social behaviorGO:00351769.3SLC6A4, OXT
20response to estradiolGO:00323559.3ESR1, OXT, SLC6A4
21positive regulation of cytosolic calcium ion concentrationGO:00072049.1CALCA, OXT, ESR1
22synaptic transmissionGO:00072689.0PNOC, COMT, MAOA, CRH

Molecular functions related to Postpartum Depression according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.4CRH, PNOC
2hormone activityGO:00051799.1CRH, CALCA, PRL

Products for genes affiliated with Postpartum Depression

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Sources for Postpartum Depression

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4CDC
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24GTR
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26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet