MCID: PST026
MIFTS: 29

Postphlebitic Syndrome malady

Summaries for Postphlebitic Syndrome

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Post-thrombotic syndrome (PTS, also called post-phlebitic syndrome and venous stress disorder) is the... more...

MalaCards: Postphlebitic Syndrome, also known as postphlebetic syndrome with ulcer and inflammation, is related to venous thrombosis and n syndrome. An important gene associated with Postphlebitic Syndrome is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The compounds inogatran and hirugen have been mentioned in the context of this disorder.

Aliases & Classifications for Postphlebitic Syndrome

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

postphlebitic syndrome 8 45 61
postphlebetic syndrome with ulcer and inflammation 8
postphlebetic syndrome with inflammation 8
postphlebetic syndrome with ulcer 8


External Ids:

Disease Ontology8 DOID:2364
MeSH35 D011186
ICD9CM27 459.1

Related Diseases for Postphlebitic Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Postphlebitic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1venous thrombosis30.1SERPINC1, F5
2n syndrome10.2
3thrombophlebitis10.2
4varicose veins10.2
5reflex sympathetic dystrophy10.1
6lipodermatosclerosis10.1
7young syndrome10.1
8sneddon syndrome10.0SERPINC1
9coronary thrombosis10.0SERPINC1
10thrombocytosis10.0SERPINC1
11sarcoma10.0DES
12branch retinal artery occlusion10.0F5
13retinal vascular occlusion10.0F5
14respiratory failure10.0SERPINC1
15central retinal vein occlusion10.0F5
16patent foramen ovale10.0F5
17ovarian hyperstimulation syndrome10.0F5
18pulmonary embolism10.0SERPINC1, F5
19legg-calve-perthes disease10.0F5, SERPINC1
20prothrombin deficiency10.0F5, SERPINC1
21hepatic vein thrombosis10.0F5, SERPINC1
22sagittal sinus thrombosis10.0F5, SERPINC1
23blood protein disease10.0F5, SERPINC1
24intracranial thrombosis10.0SERPINC1, F5
25antithrombin iii deficiency10.0SERPINC1, F5
26purpura fulminans10.0SERPINC1, F5
27dysfibrinogenemia10.0F5, SERPINC1
28hemorrhagic disease10.0SERPINC1, F5
29factor xii deficiency10.0SERPINC1, F5
30meningococcemia10.0SERPINC1, F5
31factor viii deficiency10.0SERPINC1, F5
32factor vii deficiency10.0SERPINC1, F5
33pregnancy loss10.0SERPINC1, F5
34portal vein thrombosis10.0F5, SERPINC1
35protein s deficiency10.0F5, SERPINC1
36severe pre-eclampsia10.0SERPINC1, F5
37protein c deficiency10.0SERPINC1, F5
38homocystinuria10.0F5, SERPINC1
39placental abruption10.0SERPINC1, F5
40retinal vein occlusion10.0F5, SERPINC1
41hellp syndrome10.0SERPINC1, F5
42thrombophilia10.0F5, SERPINC1
43disseminated intravascular coagulation10.0SERPINC1, F5
44septic shock10.0SERPINC1, F5
45antiphospholipid syndrome10.0SERPINC1, F5
46hyperhomocysteinemia10.0F5, SERPINC1
47stroke, ischemic10.0SERPINC1, F5
48vascular disease10.0F5, SERPINC1
49factor v leiden thrombophilia10.0SERPINC1, F5
50sepsis10.0SERPINC1, F5

Graphical network of the top 20 diseases related to Postphlebitic Syndrome:



Diseases related to postphlebitic syndrome

Clinical Features for Postphlebitic Syndrome

Drugs & Therapeutics for Postphlebitic Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Postphlebitic Syndrome

Drug clinical trials:

Search ClinicalTrials for Postphlebitic Syndrome

Search NIH Clinical Center for Postphlebitic Syndrome

Search CenterWatch for Postphlebitic Syndrome

Genetic Tests for Postphlebitic Syndrome

Anatomical Context for Postphlebitic Syndrome

Animal Models for Postphlebitic Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Postphlebitic Syndrome

Sources:
51PubMed
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Articles related to Postphlebitic Syndrome:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Prevention and treatment of postphlebitic syndrome: results of a 3-part study. (11570939)
2001
2
The effects of heparin and oral anticoagulants on thrombus propagation and prevention of the postphlebitic syndrome: a critical review of the literature. (11533928)
2001
3
Does the location of deep venous thrombosis affect the risk of developing postphlebitic syndrome? (11245494)
2001
4
Postphlebitic syndrome after total knee arthroplasty: 405 patients examined 2-10 years after surgery. (11327412)
2001
5
Combined genetic defect (homogeneity for factor V Leiden and heterogeneity for prothrombin G20210A allele), in a young patient, with recurrent deep vein thrombosis and serious postphlebitic syndrome--a case report. (10779003)
2000
6
Long-term outcomes after deep vein thrombosis: postphlebitic syndrome and quality of life. (10886478)
2000
7
Heparan sulfate in the therapy of postphlebitic syndrome. Evaluation of the efficacy and tolerability as compared to mesoglycan]. (9432569)
1997
8
Lipodermatosclerosis: a postphlebitic syndrome. (9466202)
1997
9
Postphlebitic syndrome: clinical activity and tolerability of desmin, new LMW dermatan sulfate. (8873586)
1996
10
Postphlebitic syndrome after hip arthroplasty. 43 patients followed at least 5 years. (7839842)
1994
11
Chronic femoral arteriovenous fistula masquerading as the postphlebitic syndrome. (1744493)
1991
12
Postphlebitic syndrome and general surgery: an epidemiologic investigation. (2035891)
1991
13
Intermittent compression units for the postphlebitic syndrome. A pilot study. (2742439)
1989
14
Antithrombotic treatment during acute inflammatory complications of patients affected by postphlebitic syndrome: LMW-heparin versus standard heparin. (2850325)
1988
15
Causalgic form of postphlebitic syndrome. A variety of reflex sympathetic dystrophy caused by acute deep thrombophlebitis. (3176488)
1988
16
The postphlebitic syndrome following shaft fractures of the leg. A significant late complication. (3680341)
1987
17
Postphlebitic syndrome after fractures of the leg. (3121017)
1987
18
Haemodynamics of the postphlebitic syndrome. (3323354)
1987
19
Distribution of venous valvular incompetence in patients with the postphlebitic syndrome. (3510328)
1986
20
Distribution of venous valvular incompetence in patients with the postphlebitic syndrome. (3534327)
1986
21
MA1nchausen's syndrome presenting with postphlebitic syndrome. (3765605)
1986
22
A combined study of the strain gauge plethysmography and I-125 fibrinogen leg scan in the differentiation of deep vein thrombosis and postphlebitic syndrome. (6497179)
1984
23
The postphlebitic syndrome. Pathophysiology, prevention and management. (6386296)
1984
24
Postphlebitic syndrome. (6536397)
1984
25
Surgical treatment of postphlebitic syndrome with vein valve transplant. (7102929)
1982
26
Remote results of the treatment of the postphlebitic syndrome. (829096)
1976
27
Noninvasive quantitation of venous hemodynamics in the postphlebitic syndrome. (4744295)
1973
28
Noninvasive quantitation of venous reflux in the postphlebitic syndrome. (4701908)
1973
29
The postphlebitic syndrome and varicose veins. (6025499)
1967
30
AUTOGENOUS VEIN GRAFT REPLACEMENT OF THROMBOSED DEEP VEINS. EXPERIMENTAL APPROACH TO THE TREATMENT OF THE POSTPHLEBITIC SYNDROME. (14114257)
1964
31
The management of postphlebitic syndrome. (13751586)
1961
32
Lymphography in postphlebitic syndrome. (13768548)
1960
33
Vein transplants and grafts in the surgical treatment of the postphlebitic syndrome. (14429961)
1960
34
Ancillary care in postphlebitic syndrome. (13625092)
1959
35
The postphlebitic syndrome. (13563242)
1958
36
Management of postphlebitic syndrome; dynamic pathologic physiology and medical therapy. (13438242)
1957
37
Medical management of thrombophlebitis and postphlebitic syndrome; survey of four hundred treated cases from a series of seven hundred seventy-nine consecutive cases of phlebitis. (13462841)
1957
38
Indications for surgical treatment of the postphlebitic syndrome. (13391391)
1957
39
Postphlebitic syndrome. (13448937)
1957
40
Postphlebitic syndrome; major vein ligation and/or lumbar sympathectomy. (13313894)
1956
41
Venography and surgery of the postphlebitic syndrome. (14396700)
1955
42
The postphlebitic syndrome; a study of possible factors in subjective disability. (13150195)
1954
43
The postphlebitic syndrome. (13201823)
1954
44
Surgical treatment of the postphlebitic syndrome. (13189010)
1954
45
The postphlebitic syndrome; discussion of surgical treatment. (13058177)
1953
46
Treatment of varicose veins and the postphlebitic syndrome. (13090076)
1953
47
Modern concepts in the treatment of the postphlebitic syndrome with ulcerations of the lower extremity. (12996889)
1952
48
Venography in the postphlebitic syndrome. (15429825)
1950
49
Postphlebitic syndrome; treatment of conservative measures, sympathectomy, and other operative measures. (15403774)
1950
50
The basis of treatment in the postphlebitic syndrome. (18147311)
1949

Genetic Variations for Postphlebitic Syndrome

Expression for genes affiliated with Postphlebitic Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Postphlebitic Syndrome

Search GEO for disease gene expression data for Postphlebitic Syndrome.

Pathways for genes affiliated with Postphlebitic Syndrome

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 52QIAGEN
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Pathways related to Postphlebitic Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.0SERPINC1, F5
2
Hide members
9.0SERPINC1, F5
3
Hide members
9.0SERPINC1, F5

Compounds for genes affiliated with Postphlebitic Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Postphlebitic Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1inogatran459.5F5, SERPINC1
2hirugen459.5SERPINC1, F5
3ecarin459.5SERPINC1, F5
4spectrozyme459.5F5, SERPINC1
5nafamostat mesilate459.5SERPINC1, F5
6danaparoid459.5SERPINC1, F5
7eltrombopag50 1110.5F5, SERPINC1
8ancrod459.5F5, SERPINC1
9ximelagatran45 1110.5F5, SERPINC1
10heparinoids459.5SERPINC1, F5
11fondaparinux459.5F5, SERPINC1
12bivalirudin45 1110.4SERPINC1, F5
13desogestrel45 1110.4SERPINC1, F5
14argatroban45 1110.4SERPINC1, F5
15gabexate mesilate459.4F5, SERPINC1
16protamine sulfate459.4SERPINC1, F5
17gestodene45 1110.4SERPINC1, F5
18benzamidine45 1110.4SERPINC1, F5
19ristocetin459.4SERPINC1, F5
20tibolone459.4F5, SERPINC1
21levonorgestrel45 60 29 1112.4SERPINC1, F5
22heparan sulfate45 2410.4SERPINC1, DES
23desmopressin45 60 29 1112.4SERPINC1, F5
24coumarin45 2 50 2412.4SERPINC1, F5
25fluorescein45 1110.4F5, SERPINC1
26hirudin459.4SERPINC1, F5
27protamine459.4F5, SERPINC1
28raloxifene45 29 50 1112.4SERPINC1, F5
29dextran sulfate459.3SERPINC1, F5
30warfarin45 50 11 2412.3F5, SERPINC1
31sodium dodecylsulfate459.3DES, F5
32kininogen459.3SERPINC1, F5
33aprotinin45 1110.3SERPINC1, F5
34p002459.3F5, DES
35polyethylene glycol459.3SERPINC1, F5
36homocysteine45 2410.2SERPINC1, F5
37citrate459.1SERPINC1, F5
38folate459.0F5, SERPINC1
39aspirin45 50 29 2412.0SERPINC1, F5
40dermatan sulfate459.0SERPINC1, DES, F5
41progestin459.0SERPINC1, DES, F5
42prostacyclin458.9SERPINC1, F5
43fibrinogen458.9F5, DES, SERPINC1
44creatinine458.9SERPINC1, DES, F5
45heparin45 29 11 2411.9F5, DES, SERPINC1
46testosterone45 60 11 2411.8SERPINC1, DES, F5
47nacl458.8DES, F5
48vegf458.8SERPINC1, DES, F5
49arginine458.8F5, DES, SERPINC1
50estrogen458.7F5, DES, SERPINC1

GO Terms for genes affiliated with Postphlebitic Syndrome

Products for genes affiliated with Postphlebitic Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Postphlebitic Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet