MCID: PST026
MIFTS: 32

Postphlebitic Syndrome malady

Summaries for Postphlebitic Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Post-thrombotic syndrome (PTS, also called post-phlebitic syndrome and venous stress disorder) is the... more...

MalaCards: Postphlebitic Syndrome, also known as postphlebetic syndrome with ulcer and inflammation, is related to thrombophlebitis and arteriovenous fistula. An important gene associated with Postphlebitic Syndrome is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The compounds inogatran and ecarin have been mentioned in the context of this disorder.

Aliases & Classifications for Postphlebitic Syndrome

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

postphlebitic syndrome 8 44 60
postphlebetic syndrome with ulcer and inflammation 8
postphlebetic syndrome with inflammation 8
postphlebetic syndrome with ulcer 8


External Ids:

Disease Ontology8 DOID:2364
MeSH34 D011186
ICD9CM27 459.1

Related Diseases for Postphlebitic Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Postphlebitic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophlebitis10.2
2arteriovenous fistula10.1
3reflex sympathetic dystrophy10.1
4phlebitis10.1
5sneddon syndrome10.0SERPINC1
6coronary thrombosis10.0SERPINC1
7thrombocytosis10.0SERPINC1
8sarcoma10.0DES
9branch retinal artery occlusion10.0F5
10retinal vascular occlusion10.0F5
11respiratory failure10.0SERPINC1
12central retinal vein occlusion10.0F5
13patent foramen ovale10.0F5
14ovarian hyperstimulation syndrome10.0F5
15pulmonary embolism10.0SERPINC1, F5
16legg-calve-perthes disease10.0F5, SERPINC1
17prothrombin deficiency10.0F5, SERPINC1
18hepatic vein thrombosis10.0F5, SERPINC1
19sagittal sinus thrombosis10.0F5, SERPINC1
20blood protein disease10.0F5, SERPINC1
21intracranial thrombosis10.0SERPINC1, F5
22antithrombin iii deficiency10.0SERPINC1, F5
23purpura fulminans10.0SERPINC1, F5
24dysfibrinogenemia10.0F5, SERPINC1
25hemorrhagic disease10.0SERPINC1, F5
26factor xii deficiency10.0SERPINC1, F5
27meningococcemia10.0SERPINC1, F5
28factor viii deficiency10.0SERPINC1, F5
29factor vii deficiency10.0SERPINC1, F5
30pregnancy loss10.0SERPINC1, F5
31portal vein thrombosis10.0F5, SERPINC1
32protein s deficiency10.0F5, SERPINC1
33severe pre-eclampsia10.0SERPINC1, F5
34protein c deficiency10.0SERPINC1, F5
35homocystinuria10.0F5, SERPINC1
36placental abruption10.0SERPINC1, F5
37retinal vein occlusion10.0F5, SERPINC1
38venous thrombosis10.0SERPINC1, F5
39hellp syndrome10.0SERPINC1, F5
40thrombophilia10.0F5, SERPINC1
41disseminated intravascular coagulation10.0SERPINC1, F5
42septic shock10.0SERPINC1, F5
43antiphospholipid syndrome10.0SERPINC1, F5
44hyperhomocysteinemia10.0F5, SERPINC1
45stroke, ischemic10.0SERPINC1, F5
46vascular disease10.0F5, SERPINC1
47factor v leiden thrombophilia10.0SERPINC1, F5
48sepsis10.0SERPINC1, F5
49pre-eclampsia10.0SERPINC1, F5
50thromboembolism10.0SERPINC1, F5

Graphical network of the top 20 diseases related to Postphlebitic Syndrome:



Diseases related to postphlebitic syndrome

Clinical Features for Postphlebitic Syndrome

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Drugs & Therapeutics for Postphlebitic Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Postphlebitic Syndrome

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Anatomical Context for Postphlebitic Syndrome

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Animal Models for Postphlebitic Syndrome or affiliated genes

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Publications for Postphlebitic Syndrome

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Sources:
50PubMed
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Articles related to Postphlebitic Syndrome:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Prevention and treatment of postphlebitic syndrome: results of a 3-part study. (11570939)
2001
2
The effects of heparin and oral anticoagulants on thrombus propagation and prevention of the postphlebitic syndrome: a critical review of the literature. (11533928)
2001
3
Does the location of deep venous thrombosis affect the risk of developing postphlebitic syndrome? (11245494)
2001
4
Postphlebitic syndrome after total knee arthroplasty: 405 patients examined 2-10 years after surgery. (11327412)
2001
5
Combined genetic defect (homogeneity for factor V Leiden and heterogeneity for prothrombin G20210A allele), in a young patient, with recurrent deep vein thrombosis and serious postphlebitic syndrome--a case report. (10779003)
2000
6
Long-term outcomes after deep vein thrombosis: postphlebitic syndrome and quality of life. (10886478)
2000
7
Heparan sulfate in the therapy of postphlebitic syndrome. Evaluation of the efficacy and tolerability as compared to mesoglycan]. (9432569)
1997
8
Lipodermatosclerosis: a postphlebitic syndrome. (9466202)
1997
9
Postphlebitic syndrome: clinical activity and tolerability of desmin, new LMW dermatan sulfate. (8873586)
1996
10
Postphlebitic syndrome after hip arthroplasty. 43 patients followed at least 5 years. (7839842)
1994
11
Chronic femoral arteriovenous fistula masquerading as the postphlebitic syndrome. (1744493)
1991
12
Postphlebitic syndrome and general surgery: an epidemiologic investigation. (2035891)
1991
13
Intermittent compression units for the postphlebitic syndrome. A pilot study. (2742439)
1989
14
Antithrombotic treatment during acute inflammatory complications of patients affected by postphlebitic syndrome: LMW-heparin versus standard heparin. (2850325)
1988
15
Causalgic form of postphlebitic syndrome. A variety of reflex sympathetic dystrophy caused by acute deep thrombophlebitis. (3176488)
1988
16
The postphlebitic syndrome following shaft fractures of the leg. A significant late complication. (3680341)
1987
17
Postphlebitic syndrome after fractures of the leg. (3121017)
1987
18
Haemodynamics of the postphlebitic syndrome. (3323354)
1987
19
Distribution of venous valvular incompetence in patients with the postphlebitic syndrome. (3510328)
1986
20
Distribution of venous valvular incompetence in patients with the postphlebitic syndrome. (3534327)
1986
21
MA1nchausen's syndrome presenting with postphlebitic syndrome. (3765605)
1986
22
A combined study of the strain gauge plethysmography and I-125 fibrinogen leg scan in the differentiation of deep vein thrombosis and postphlebitic syndrome. (6497179)
1984
23
The postphlebitic syndrome. Pathophysiology, prevention and management. (6386296)
1984
24
Postphlebitic syndrome. (6536397)
1984
25
Pathogenesis of the postphlebitic syndrome. (6344779)
1983
26
Surgical treatment of postphlebitic syndrome with vein valve transplant. (7102929)
1982
27
Remote results of the treatment of the postphlebitic syndrome. (829096)
1976
28
Noninvasive quantitation of venous hemodynamics in the postphlebitic syndrome. (4744295)
1973
29
The postphlebitic syndrome and varicose veins. (6025499)
1967
30
AUTOGENOUS VEIN GRAFT REPLACEMENT OF THROMBOSED DEEP VEINS. EXPERIMENTAL APPROACH TO THE TREATMENT OF THE POSTPHLEBITIC SYNDROME. (14114257)
1964
31
The management of postphlebitic syndrome. (13751586)
1961
32
Lymphography in postphlebitic syndrome. (13768548)
1960
33
Vein transplants and grafts in the surgical treatment of the postphlebitic syndrome. (14429961)
1960
34
Ancillary care in postphlebitic syndrome. (13625092)
1959
35
The postphlebitic syndrome. (13563242)
1958
36
Management of postphlebitic syndrome; dynamic pathologic physiology and medical therapy. (13438242)
1957
37
Medical management of thrombophlebitis and postphlebitic syndrome; survey of four hundred treated cases from a series of seven hundred seventy-nine consecutive cases of phlebitis. (13462841)
1957
38
Indications for surgical treatment of the postphlebitic syndrome. (13391391)
1957
39
Postphlebitic syndrome. (13448937)
1957
40
Postphlebitic syndrome; major vein ligation and/or lumbar sympathectomy. (13313894)
1956
41
Venography and surgery of the postphlebitic syndrome. (14396700)
1955
42
The postphlebitic syndrome; a study of possible factors in subjective disability. (13150195)
1954
43
The postphlebitic syndrome. (13201823)
1954
44
Surgical treatment of the postphlebitic syndrome. (13189010)
1954
45
The postphlebitic syndrome; discussion of surgical treatment. (13058177)
1953
46
Treatment of varicose veins and the postphlebitic syndrome. (13090076)
1953
47
Modern concepts in the treatment of the postphlebitic syndrome with ulcerations of the lower extremity. (12996889)
1952
48
Venography in the postphlebitic syndrome. (15429825)
1950
49
Postphlebitic syndrome; treatment of conservative measures, sympathectomy, and other operative measures. (15403774)
1950
50
The basis of treatment in the postphlebitic syndrome. (18147311)
1949

Genetic Variations for Postphlebitic Syndrome

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Expression for genes affiliated with Postphlebitic Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Postphlebitic Syndrome

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Pathways for genes affiliated with Postphlebitic Syndrome

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29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 51QIAGEN
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Pathways related to Postphlebitic Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.0SERPINC1, F5
2
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9.0SERPINC1, F5
3
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9.0SERPINC1, F5

Compounds for genes affiliated with Postphlebitic Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Postphlebitic Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idCompoundScoreTop Affiliating Genes
1inogatran449.5F5, SERPINC1
2ecarin449.5F5, SERPINC1
3hirugen449.5F5, SERPINC1
4spectrozyme449.5SERPINC1, F5
5nafamostat mesilate449.5F5, SERPINC1
6danaparoid449.5SERPINC1, F5
7eltrombopag49 1110.5F5, SERPINC1
8ancrod449.5F5, SERPINC1
9ximelagatran44 1110.5SERPINC1, F5
10heparinoids449.5F5, SERPINC1
11fondaparinux449.5SERPINC1, F5
12bivalirudin44 1110.4F5, SERPINC1
13argatroban44 1110.4F5, SERPINC1
14desogestrel44 1110.4SERPINC1, F5
15gabexate mesilate449.4SERPINC1, F5
16protamine sulfate449.4SERPINC1, F5
17gestodene44 1110.4SERPINC1, F5
18benzamidine44 1110.4SERPINC1, F5
19ristocetin449.4F5, SERPINC1
20tibolone449.4SERPINC1, F5
21levonorgestrel44 59 28 1112.4SERPINC1, F5
22heparan sulfate44 2410.4DES, SERPINC1
23coumarin44 2 49 2412.4SERPINC1, F5
24desmopressin44 59 28 1112.4SERPINC1, F5
25fluorescein44 1110.4F5, SERPINC1
26hirudin449.4SERPINC1, F5
27protamine449.4SERPINC1, F5
28raloxifene44 28 49 1112.4SERPINC1, F5
29dextran sulfate449.3SERPINC1, F5
30warfarin44 49 11 2412.3F5, SERPINC1
31sodium dodecylsulfate449.3DES, F5
32kininogen449.3F5, SERPINC1
33aprotinin44 1110.3SERPINC1, F5
34p002449.3F5, DES
35polyethylene glycol449.3F5, SERPINC1
36homocysteine44 2410.2SERPINC1, F5
37citrate449.1SERPINC1, F5
38folate449.0F5, SERPINC1
39aspirin44 49 28 2412.0SERPINC1, F5
40dermatan sulfate449.0SERPINC1, DES, F5
41progestin449.0F5, SERPINC1, DES
42prostacyclin448.9SERPINC1, F5
43fibrinogen448.9F5, SERPINC1, DES
44creatinine448.9DES, F5, SERPINC1
45heparin44 28 11 2411.9F5, SERPINC1, DES
46testosterone44 59 11 2411.8SERPINC1, F5, DES
47nacl448.8DES, F5
48vegf448.8F5, SERPINC1, DES
49arginine448.8SERPINC1, F5, DES
50estrogen448.7SERPINC1, F5, DES

GO Terms for genes affiliated with Postphlebitic Syndrome

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Products for genes affiliated with Postphlebitic Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Postphlebitic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet