Aliases & Classifications for Pouchitis

MalaCards integrated aliases for Pouchitis:

Name: Pouchitis 56 52 69

Characteristics:

Orphanet epidemiological data:

56
pouchitis
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Orphanet 56 ORPHA217067
MESH via Orphanet 43 D019449
UMLS via Orphanet 70 C0376620

Summaries for Pouchitis

MalaCards based summary : Pouchitis is related to sclerosing cholangitis and microscopic colitis. An important gene associated with Pouchitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ciprofloxacin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Wikipedia : 72 Pouchitis is inflammation of the ileal pouch (an artificial rectum surgically created out of ileal gut... more...

Related Diseases for Pouchitis

Diseases related to Pouchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
id Related Disease Score Top Affiliating Genes
1 sclerosing cholangitis 29.7 CXCL8 LTF
2 microscopic colitis 27.9 CXCL8 IL10 NOD2 TLR4
3 colitis 10.6
4 ulcerative colitis 10.6
5 membranoproliferative glomerulonephritis 10.4 IL1RN NOD2
6 migraine with or without aura 5 10.4 NOD2 TLR4
7 gastroduodenal crohn's disease 10.4 NOD2 TLR4
8 neonatal meningitis 10.4 IL1RN TLR4
9 psoriasis susceptibility 1 10.3 IL1RN NOD2
10 acute monoblastic leukemia 10.3 IL10 NOD2
11 mikulicz disease 10.2 LTF TLR4
12 noma 10.2 IL10 IL1RN
13 askin's tumor 10.2 IL10 IL1RN
14 alkhurma hemorrhagic fever 10.2 IL10 TLR4
15 megaloblastic anemia 10.2 IL10 TLR4
16 bartonellosis 10.2 IL10 TLR4
17 abnormal retinal correspondence 10.1 IL10 TLR4
18 mucositis 10.1
19 acute gonococcal cystitis 10.1 CXCL8 NOD2
20 melioidosis 10.1 IL10 TLR4
21 amyotrophic lateral sclerosis type 10 10.1 CXCL8 NOD2
22 lip cancer 10.1 CXCL8 NOD2
23 inflammatory bowel disease 10.1
24 myopathy 10.1 CXCL8 NOD2
25 gastric ulcer 10.1 IL10 TLR4
26 orthostatic proteinuria 10.1 CXCL8 IL1RN
27 crohn's disease 10.0
28 lymphangiectasia, intestinal 10.0 CXCL8 LTF
29 retinal vascular disease 10.0 CXCL8 LTF
30 halal setton wang syndrome 10.0 CXCL8 LTF
31 burns 10.0 CXCL8 IL1RN
32 subglottis neoplasm 10.0 CXCL8 TLR4
33 follicular mucinosis 10.0 CXCL8 TLR4
34 opportunistic bacterial infectious disease 10.0 IL10 TLR4
35 tibialis tendinitis 10.0 CXCL8 IL1RN
36 lateral cystocele 10.0 CXCL8 TLR4
37 dengue disease 10.0 IL10 TLR4
38 thymus clear cell carcinoma 10.0 CXCL8 TLR4
39 familial adenomatous polyposis 10.0
40 ileitis 10.0
41 testicular infarct 10.0 CXCL8 TLR4
42 myeloid sarcoma 10.0 CXCL8 TLR4
43 deafness, autosomal recessive 62 10.0 IL10 TLR4
44 sinusitis 9.9 CXCL8 IL1RN
45 tinea barbae 9.9 CXCL8 TLR4
46 arthritis 9.9
47 cytomegalovirus infection 9.9
48 basidiobolomycosis 9.9 CXCL8 IL10
49 lymph node palisaded myofibroblastoma 9.9 CXCL8 IL10
50 drug rash with eosinophilia and systemic symptoms 9.9 CXCL8 IL10

Graphical network of the top 20 diseases related to Pouchitis:



Diseases related to Pouchitis

Symptoms & Phenotypes for Pouchitis

GenomeRNAi Phenotypes related to Pouchitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.36 NOD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.36 IL10
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.36 IL10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.36 NOD2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.36 IL10
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 IL10
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.36 IL10
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.36 IL10 NOD2 TLR4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.36 NOD2

Drugs & Therapeutics for Pouchitis

Drugs for Pouchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
2 Vedolizumab Approved Phase 4 943609-66-3
3
Certolizumab pegol Approved Phase 4 428863-50-7
4 Antirheumatic Agents Phase 4,Phase 3
5 Gastrointestinal Agents Phase 4,Phase 3
6 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Topoisomerase Inhibitors Phase 4
9 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
10 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
11 Immunosuppressive Agents Phase 4,Phase 3
12
Adalimumab Approved Phase 3 331731-18-1 16219006
13 Anti-Inflammatory Agents Phase 3
14
Alicaforsen Phase 3 185229-68-9 16197724
15 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
16
Menthol Approved Phase 2 2216-51-5 16666
17
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
18 Antitubercular Agents Phase 2
19 Defensins
20 Scopolamine hydrobromide 114-49-8
21 Butylscopolammonium Bromide
22 Immunoglobulins
23 Antibodies
24 Acidophilus Nutraceutical

Interventional clinical trials:

(show all 22)

id Name Status NCT ID Phase Drugs
1 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
2 Phase 4 Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis Recruiting NCT02790138 Phase 4 Vedolizumab;Ciprofloxacin;Vedolizumab Placebo
3 EUS Evaluation of Perianal and Peri-rectal Fistulizing Crohn's Disease With CERTOLIZUMAB Treatment Terminated NCT01582568 Phase 4 Certolizumab
4 Adalimumab in the Treatment of Chronic Pouchitis Completed NCT01670240 Phase 3 Adalimumab;Placebo
5 Clinical Approaches to Ileal Pouch Dysfunction Completed NCT00293553 Phase 3
6 Randomized Study of Topical Alicaforsen Enema in Antibiotic Refractory Pouchitis Recruiting NCT02525523 Phase 3 Alicaforsen;Placebo
7 To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis Completed NCT02201186 Phase 2
8 Safety and Efficacy of AST-120 in the Treatment of Pouchitis Completed NCT00583076 Phase 2 AST-120
9 FMT in Ulcerative Colitis-Associated Pouchitis Recruiting NCT02049502 Phase 2
10 Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP) Recruiting NCT02782325 Phase 1, Phase 2
11 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2 Clotrimazole
12 Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis Terminated NCT00583531 Phase 2 AST-120
13 Study of Sc-FOS for Pouchitis Prevention Active, not recruiting NCT02203955 Phase 1 Short-Chain Fructooligosaccharide;Maltodextrin
14 The Interaction Between Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis Unknown status NCT01202396
15 Clinical Outcome After Close Rectal Ileo Pouch Anal Anastomosis for Colitis Ulcerosa(CU) Unknown status NCT01111708
16 Surgical Reconstruction in Ulcerative Colitis With Primary Sclerosing Cholangitis Completed NCT01798953
17 Characterization of Disease Related Changes in Inflammatory Bowel Disease Using Fecal Metabolite Profiling Completed NCT01666717
18 Microbiota and Immune microEnvironment in Pouchitis Recruiting NCT03136419
19 MRI in Normal Ileal Pouches, and a Feasibility Study of Dynamic MRI Enema and Defaecating MRI Pouchography Recruiting NCT02925260
20 Fecal Microbiota Transplant (FMT) for Pouchitis Active, not recruiting NCT02428361 Early Phase 1 Biologically active human fecal material, OpenBiome
21 Nutritional Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With IPAA Active, not recruiting NCT02828410
22 Corrona Inflammatory Bowel Disease (IBD) Registry Enrolling by invitation NCT03162549

Search NIH Clinical Center for Pouchitis

Genetic Tests for Pouchitis

Anatomical Context for Pouchitis

MalaCards organs/tissues related to Pouchitis:

39
Small Intestine, Liver, Colon, Endothelial, Neutrophil, T Cells, Testes

Publications for Pouchitis

Articles related to Pouchitis:

(show top 50) (show all 412)
id Title Authors Year
1
Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. ( 28221248 )
2017
2
Efficacy of granulocyte and monocyte apheresis for antibiotic-refractory pouchitis after proctocolectomy for ulcerative colitis: an open-label, prospective, multicentre study. ( 28203278 )
2017
3
Frequency and Risk Factors of Clostridium difficile Infection in Hospitalized Patients With Pouchitis: A Population-based Study. ( 28296825 )
2017
4
Refractory pouchitis improves after administration of the green tea polyphenol EGCG: a retrospective review. ( 28929216 )
2017
5
Pouchitis after ileal pouch-anal anastomosis in ulcerative colitis: Diagnosis, management, risk factors, and incidence. ( 27681447 )
2017
6
Cryptosporidium Pouchitis. ( 28223201 )
2017
7
Colonic Histological Criteria Predict Development of Pouchitis after Ileal Pouch: Anal Anastomosis for Patients with Ulcerative Colitis. ( 28662525 )
2017
8
Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. ( 28248733 )
2017
9
Preoperative Extraintestinal Manifestations Associated with Chronic Pouchitis in Japanese Patients with Ulcerative Colitis After Ileal Pouch-anal Anastomosis: A Retrospective Study. ( 28346273 )
2017
10
Efficacy of Vedolizumab in Patients with Antibiotic and Anti-tumor Necrosis Alpha Refractory Pouchitis. ( 27930413 )
2017
11
Intestinal Barrier Disruption in Ileal Pouchitis After Ileal Pouch-Anal Anastomosis in a Rat Model. ( 28486255 )
2017
12
Endoscopic Treatment of Bleeding Diversion Pouchitis with High-Concentration Dextrose Spray. ( 28377939 )
2017
13
Successful Treatment With Ustekinumab for Chronic Refractory Pouchitis. ( 28199485 )
2017
14
Successful treatment of chronic refractory pouchitis with vedolizumab. ( 28698974 )
2017
15
NOD2 genetic variants predispose one of two familial adenomatous polyposis siblings to pouchitis through microbiome dysbiosis. ( 28633443 )
2017
16
Predictors of pouchitis after ileal pouch-anal anastomosis in pediatric-onset ulcerative colitis. ( 28542114 )
2017
17
Central Serous Chorioretinopathy in a Patient with Ulcerative Colitis with Pouchitis on Budesonide-EC. ( 28328626 )
2017
18
Combination therapy with vedolizumab and etanercept in a patient with pouchitis and spondylarthritis. ( 28243458 )
2017
19
Tripterygium wilfordii polyglycosidium ameliorates pouchitis induced by dextran sulfate sodium in rats. ( 27988458 )
2017
20
Altered expression of microRNAs in patients with pouchitis after restorative proctocolectomy. ( 28600635 )
2017
21
Successful treatment of pouchitis with Vedolizumab, but not fecal microbiota transfer (FMT), after proctocolectomy in ulcerative colitis. ( 28097380 )
2017
22
Lactobacillus acidophilus alleviates pouchitis after ileal pouch-anal anastomosis in rats. ( 28765694 )
2017
23
Sulfasalazine in Prevention of Pouchitis After Proctocolectomy with Ileal Pouch-Anal Anastomosis for Ulcerative Colitis. ( 28110377 )
2017
24
Pouchitis in Pediatric Ulcerative Colitis Patients After Ileal Pouch Anal Anastomosis. ( 27602702 )
2016
25
Endoluminal calprotectin measurement in assessment of pouchitis and a new index of disease activity: a pilot study. ( 26901424 )
2016
26
Fecal microbiota in pouchitis and ulcerative colitis. ( 27833384 )
2016
27
The current place of probiotics and prebiotics in the treatment of pouchitis. ( 27048898 )
2016
28
Predictors of Pouchitis After Ileal Pouch-Anal Anastomosis in Children. ( 27243421 )
2016
29
The prevalence of chronic peri-pouch sepsis in patients treated for antibiotic-dependent or refractory primary idiopathic pouchitis. ( 27688067 )
2016
30
Campylobacter Pouchitis Mimicking the Appearance of Crohn's Disease. ( 27555972 )
2016
31
Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm. ( 28008631 )
2016
32
Alicaforsen, an antisense inhibitor of ICAM-1, as treatment for chronic refractory pouchitis after proctocolectomy: A case series. ( 26966529 )
2016
33
Secondary pouchitis in a pediatric patient successfully treated by salvage surgery. ( 27097567 )
2016
34
Patient-Specific Bacteroides Genome Variants in Pouchitis. ( 27935837 )
2016
35
Methodological Quality Assessment of Meta-Analyses and Systematic Reviews of Probiotics in Inflammatory Bowel Disease and Pouchitis. ( 28005973 )
2016
36
Reply to a Letter to the Editor Regarding the Original Article, Predictors of Pouchitis After Ileal Pouch-Anal Anastomosis in Children. ( 27574882 )
2016
37
Short article: Successful faecal coliform sensitivity-based oral ertapenem therapy for chronic antibiotic-refractory pouchitis: a case series. ( 26657456 )
2016
38
Alterations of Enteric Microbiota in Patients with a Normal Ileal Pouch Are Predictive of Pouchitis. ( 27613294 )
2016
39
Pouchitis Associated With Pelvic Radiation for Prostate Cancer. ( 27807581 )
2016
40
Fecal Microbiota Transfer in Patients With Chronic Antibiotic-Refractory Pouchitis. ( 27018122 )
2016
41
Immunoglobulin G4 (IgG4)-associated pouchitis - Part of IgG4 related disease? A case series and review of the literature. ( 27038705 )
2016
42
Role of intestinal flora imbalance in pathogenesis of pouchitis. ( 27569889 )
2016
43
Review article: the pathogenesis of pouchitis. ( 27554912 )
2016
44
Pouchitis Is a Common Complication in Patients With FamilialA Adenomatous Polyposis Following Ileal Pouch-Anal Anastomosis. ( 27085760 )
2016
45
P013. Characterization of enterochromaffin cells in pouchitis after proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. ( 25718321 )
2015
46
Consecutive Monitoring of Fecal Calprotectin and Lactoferrin for the Early Diagnosis and Prediction of Pouchitis after Restorative Proctocolectomy for Ulcerative Colitis. ( 25916224 )
2015
47
The therapeutic potential of antibiotics and probiotics in the treatment of pouchitis. ( 26202437 )
2015
48
DOP086. Enteric micriobiota alterations in patients with a normal ileal pouch may be predictive of pouchitis. ( 25718302 )
2015
49
Specific members of the predominant gut microbiota predict pouchitis following colectomy and IPAA in UC. ( 26423113 )
2015
50
Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis. ( 26319238 )
2015

Variations for Pouchitis

Expression for Pouchitis

Search GEO for disease gene expression data for Pouchitis.

Pathways for Pouchitis

Pathways related to Pouchitis according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CXCL8 IL10 IL1RN LTF NOD2 TLR4
2
Show member pathways
12.95 CXCL8 IL10 IL1RN NOD2
3
Show member pathways
12.54 CXCL8 IL1RN NOD2 TLR4
4
Show member pathways
12.5 CXCL8 IL10 TLR4
5
Show member pathways
12.19 IL10 NOD2 TLR4
6 11.8 IL10 NOD2 TLR4
7 11.71 CXCL8 IL10 IL1RN
8 11.42 CXCL8 IL10 TLR4
9 11.37 IL10 TLR4
10 11.32 CXCL8 NOD2
11 11.24 CXCL8 TLR4
12 11.21 CXCL8 IL10 TLR4
13 11 IL10 TLR4
14 10.82 CXCL8 IL10 IL1RN
15 10.49 CXCL8 IL10 TLR4

GO Terms for Pouchitis

Biological processes related to Pouchitis according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 LTF NOD2 TLR4
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.69 LTF NOD2 TLR4
3 defense response to Gram-negative bacterium GO:0050829 9.63 LTF TLR4
4 regulation of inflammatory response GO:0050727 9.62 NOD2 TLR4
5 immune response GO:0006955 9.62 CXCL8 IL10 IL1RN TLR4
6 positive regulation of JNK cascade GO:0046330 9.61 NOD2 TLR4
7 response to glucocorticoid GO:0051384 9.61 IL10 IL1RN
8 positive regulation of tumor necrosis factor production GO:0032760 9.6 NOD2 TLR4
9 positive regulation of interleukin-6 production GO:0032755 9.59 NOD2 TLR4
10 negative regulation of tumor necrosis factor production GO:0032720 9.58 IL10 TLR4
11 positive regulation of interleukin-8 production GO:0032757 9.58 NOD2 TLR4
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.58 LTF NOD2 TLR4
13 negative regulation of interleukin-6 production GO:0032715 9.57 IL10 TLR4
14 negative regulation of interferon-gamma production GO:0032689 9.55 IL10 TLR4
15 positive regulation of interleukin-10 production GO:0032733 9.54 NOD2 TLR4
16 cellular response to lipopolysaccharide GO:0071222 9.54 CXCL8 IL10 TLR4
17 positive regulation of stress-activated MAPK cascade GO:0032874 9.52 NOD2 TLR4
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.46 NOD2 TLR4
19 response to molecule of bacterial origin GO:0002237 9.43 CXCL8 IL10
20 positive regulation of interleukin-1 beta secretion GO:0050718 9.26 NOD2
21 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.26 IL10 IL1RN
22 inflammatory response GO:0006954 9.26 CXCL8 IL10 IL1RN TLR4
23 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.19 NOD2
24 positive regulation of macrophage activation GO:0043032 9.18 IL10
25 positive regulation of MHC class II biosynthetic process GO:0045348 9.16 IL10 TLR4
26 defense response to bacterium GO:0042742 8.92 IL10 LTF NOD2 TLR4

Molecular functions related to Pouchitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.96 LTF TLR4
2 cytokine activity GO:0005125 8.8 CXCL8 IL10 IL1RN

Sources for Pouchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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