MCID: PCH007
MIFTS: 48

Pouchitis malady

Rare diseases category
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Summaries for Pouchitis

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Wikipedia:65 Pouchitis is inflammation of the ileal pouch (an artificial rectum surgically created out of ileal gut... more...

MalaCards based summary: Pouchitis is related to colitis and ulcerative colitis. An important gene associated with Pouchitis is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Cytosolic sensors of pathogen-associated DNA and IL-17 Family Signaling Pathways. The compounds asialo gm1 and arabinogalactan have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Pouchitis

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Sources:
48Orphanet, 62UMLS, 35MESH via Orphanet, 63UMLS via Orphanet
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Pouchitis, Aliases & Descriptions:

Name: Pouchitis 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Characteristics (Orphanet epidemiological data):

48
pouchitis:
Prevalence: 1-5/10000


External Ids:

MESH via Orphanet35 D019449
UMLS via Orphanet63 C0376620

Related Diseases for Pouchitis

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Diseases related to Pouchitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1colitis30.8TLR2, TLR4, TLR5, NOD2
2ulcerative colitis30.4TLR2, TLR4, TLR3, TLR5, NOD2
3inflammatory bowel disease30.1NOD2, TLR5, TLR4, TLR2
4arthritis29.9TLR2, TLR4, TLR3, NOD2
5hepatitis29.8TLR3, TLR2
6hepatitis c29.7TLR3, TLR4, TLR2
7blau syndrome10.4NOD2
8crohn's disease10.4
9blindness10.4
10legionnaires' disease10.4TLR5
11familial adenomatous polyposis10.3
12ileitis10.3
13cytomegalovirus infection10.3
14colorectal cancer10.3NOD2
15sclerosing cholangitis10.2
16adenocarcinoma10.2
17cholangitis10.2
18primary sclerosing cholangitis10.2
19psoriatic arthritis10.2TLR2, NOD2
20measles10.1TLR3, TLR2
21gastroduodenitis10.1
22encephalitis10.1TLR2, TLR3
23mastitis10.1TLR4, TLR2
24invasive aspergillosis10.1TLR2, TLR4
25filariasis10.0TLR2, TLR4
26neisseria meningitidis infection10.0TLR4, TLR2
27ankylosing spondylitis10.0NOD2, TLR4
28chorioamnionitis10.0TLR2, TLR4
29aspergillosis10.0TLR4, TLR2
30keratitis10.0TLR4, TLR2
31malt lymphoma10.0TLR4, TLR2
32herpes simplex10.0TLR3, TLR2
33periodontitis10.0TLR4, TLR2
34deficiency anemia10.0
35obesity10.0
36iritis10.0
37iron deficiency anemia10.0
38pyoderma gangrenosum10.0
39bursitis10.0
40microscopic colitis10.0
41pyoderma10.0
42spondyloarthropathy10.0
43uveitis10.0
44gardner syndrome10.0
45endotheliitis10.0
46periodontal disease10.0TLR4, TLR2
47septic shock9.9TLR2, TLR4
48influenza9.9TLR3, TLR5
49psoriasis9.9NOD2, TLR5, TLR2
50allergic asthma9.9TLR4, TLR2

Graphical network of the top 20 diseases related to Pouchitis:



Diseases related to pouchitis

Symptoms for Pouchitis

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Drugs & Therapeutics for Pouchitis

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Drug clinical trials:

Search ClinicalTrials for Pouchitis

Search NIH Clinical Center for Pouchitis

Genetic Tests for Pouchitis

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Anatomical Context for Pouchitis

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MalaCards organs/tissues related to Pouchitis:

32
Small intestine, Liver, Colon, Testes, T cells, Endothelial, Neutrophil

Animal Models for Pouchitis or affiliated genes

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MGI Mouse Phenotypes related to Pouchitis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.6TLR5, TLR4, TLR2
2MP:00020068.6TLR2, TLR4, TLR3
3MP:00053818.3NOD2, TLR5, TLR4, TLR2
4MP:00053888.2TLR2, TLR4, TLR3, TLR5
5MP:00053708.2TLR2, TLR4, TLR5
6MP:00053858.1TLR2, TLR4, TLR3, TLR5
7MP:00053868.1TLR2, TLR4, TLR3, TLR5
8MP:00053788.1NOD2, TLR5, TLR4, TLR2
9MP:00053848.0NOD2, TLR5, TLR4, TLR2
10MP:00053977.8NOD2, TLR5, TLR3, TLR4, TLR2
11MP:00053877.8TLR2, TLR4, TLR3, TLR5, NOD2
12MP:00053767.7TLR2, TLR4, TLR3, TLR5, NOD2

Publications for Pouchitis

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Articles related to Pouchitis:

(show top 50)    (show all 337)
idTitleAuthorsYear
1
Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohn's Disease, and Pouchitis: Meta-analysis of Randomized Controlled Trials. (24280877)
2014
2
Role of intestinal bacteria in the pathogenesis of pouchitis. (25046009)
2014
3
A treatment strategy for preventing pouchitis as a postoperative complication of ulcerative colitis: the significance of the management of cuffitis. (25022954)
2014
4
Infliximab for the treatment of pouchitis. (24303499)
2013
5
Meta-analysis: serological markers and the risk of acute and chronic pouchitis. (23480145)
2013
6
Characteristics of extremely early-onset pouchitis after proctocolectomy with ileal pouch-anal anastomosis. (23254315)
2013
7
Stricture of ileo-anal J pouch anastomosis increased the intensity of pouchitis in an experimental rat model. (23018348)
2012
8
An open study of maintenance antibiotic therapy for chronic antibiotic-dependent pouchitis: efficacy, complications and outcome. (20041929)
2011
9
Pouchitis and pouch dysfunction. (19944799)
2010
10
Diagnosis and management of pouchitis and ileoanal pouch dysfunction. (20890738)
2010
11
Early diagnosis of bilateral sub-deltoid bursitis using clinic-based ultrasonography in a patient receiving infliximab therapy for ulcerative pouchitis. (18949534)
2010
12
An assessment of bacterial dysbiosis in pouchitis using terminal restriction fragment length polymorphisms of 16S ribosomal DNA from pouch effluent microbiota. (19617766)
2009
13
Re: Adenocarcinoma arising in a background of chronic atrophic pouchitis in an ileoanal pouch for ulcerative colitis. (19302532)
2009
14
Leukocytapheresis for the treatment of active pouchitis: a pilot study. (18648745)
2008
15
Development of pouchitis following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis: A role for serological markers and microbial pattern recognition receptor genes. (21172204)
2008
16
Proliferation of immature plasma cells in pouchitis mucosa in patients with ulcerative colitis. (18452202)
2008
17
Portal vein thrombi after ileal pouch-anal anastomosis: its incidence and association with pouchitis. (17593473)
2007
18
Pouchitis. (17948934)
2007
19
Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis. (17007066)
2006
20
Systematic review: the management of pouchitis. (16611268)
2006
21
Probiotic therapy to prevent pouchitis onset. (15793632)
2005
22
Inflammatory bowel disease: a new combination therapy for pouchitis. (15976743)
2005
23
Association between fecal hydrogen sulfide production and pouchitis. (15747080)
2005
24
Diagnostic difficulties in pouchitis--experience from a single institution. (15469209)
2004
25
Human lymphocyte stimulation with pouchitis flora is greater than with flora from a healthy pouch but is suppressed by metronidazole. (15542518)
2004
26
Expression of cytokines, inducible nitric oxide synthase, and matrix metalloproteinases in pouchitis: effects of probiotic treatment. (11569697)
2001
27
Long-term follow-up after ileoanal pouch procedure: algorithm for diagnosis, classification, and management of pouchitis. (11330575)
2001
28
Increase in cyclooxygenase-2 and nitric oxide-synthase-2 mRNAs in pouchitis without modification of inducible isoenzyme heme-oxygenase-1. (11467644)
2001
29
Association of decreased perfusion of the ileoanal pouch mucosa with early postoperative pouchitis and local septic complications. (11585503)
2001
30
Simple gas chromatography analysis of faecal butyrate: application to patients at risk of pouchitis. (11256793)
2001
31
Colectomy and ileal pouch. Transport and barrier in pouchitis. (11193590)
2000
32
Pouchitis: extracolonic manifestation of ulcerative colitis? (10788837)
1999
33
IgG, albumin, and sCD44 in whole-gut lavage fluid are useful clinical markers for assessing the presence and activity of pouchitis. (10207728)
1999
34
The implications of acute pouchitis on the long-term functional results after restorative proctocolectomy. (9836080)
1998
35
Pouchitis associated with primary cytomegalovirus infection. (9468256)
1998
36
How do you treat refractory pouchitis and when do you decide to remove the pouch? (9589302)
1998
37
Stricture and pouchitis after ileal pouch-anal anastomosis. (9407824)
1997
38
Pouchitis: pathogenesis, diagnosis, and management. (8792143)
1996
39
Fecal bile acids, short-chain fatty acids, and bacteria after ileal pouch-anal anastomosis do not differ in patients with pouchitis. (7628271)
1995
40
p-ANCA and development of pouchitis in ulcerative colitis patients after proctocolectomy and ileoanal pouch anastomosis. (7916418)
1994
41
Pouchitis: result of microbial imbalance? (8200561)
1994
42
Pouchitis--recurrence of the inflammatory bowel disease? (8307476)
1994
43
Pouchitis. (7953327)
1994
44
The pull-through procedure: technical factors in influencing outcome, with emphasis on pouchitis. (8211701)
1993
45
Cyclosporin A retention enemas in refractory distal ulcerative colitis and 'pouchitis'. (8210986)
1993
46
Short-chain fatty acids in pouch contents from patients with and without pouchitis after ileal pouch-anal anastomosis. (1397871)
1992
47
Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis. (2009019)
1991
48
The pelvic ileal reservoir: pathology and pouchitis. (2172847)
1990
49
Topical administration of 5-aminosalicylic acid: a therapeutic proposal for the treatment of pouchitis. (2911318)
1989
50
Pouchitis. (3058838)
1988

Variations for Pouchitis

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Expression for genes affiliated with Pouchitis

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Expression patterns in normal tissues for genes affiliated with Pouchitis

Search GEO for disease gene expression data for Pouchitis.

Pathways for genes affiliated with Pouchitis

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Pathways related to Pouchitis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5TLR3, NOD2
2
Show member pathways
9.3TLR5, TLR2
3
Show member pathways
Immune response MIF in innate immunity response60
9.1TLR4, TLR3
49.1TLR2, TLR4
59.1TLR4, TLR2
69.1TLR4, TLR2
79.1TLR4, TLR2
89.1TLR4, TLR2
9
Show member pathways
9.1TLR2, TLR4
10
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection37
9.0TLR5, TLR4
11
Show member pathways
8.7TLR4, TLR3, NOD2
128.7TLR2, TLR4, NOD2
13
Show member pathways
8.6TLR3, TLR4, TLR2
148.6TLR3, TLR4, TLR2
15
Show member pathways
8.6NOD2, TLR5, TLR4
168.5TLR5, TLR4, TLR2
17
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.5TLR2, TLR4, TLR5
18
Show member pathways
8.1TLR2, TLR4, TLR5, NOD2
19
Show member pathways
8.0TLR2, TLR4, TLR3, TLR5
20
Show member pathways
8.0TLR2, TLR4, TLR3, TLR5
21
Show member pathways
8.0TLR2, TLR4, TLR3, TLR5
22
Show member pathways
IL27-mediated signaling events37
8.0TLR2, TLR4, TLR3, TLR5
238.0TLR5, TLR3, TLR4, TLR2
248.0TLR5, TLR3, TLR4, TLR2
25
Show member pathways
8.0TLR5, TLR3, TLR4, TLR2
26
Show member pathways
8.0TLR5, TLR3, TLR4, TLR2
27
Show member pathways
8.0TLR2, TLR4, TLR3, TLR5
28
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.0TLR2, TLR4, TLR3, TLR5
29
Show member pathways
8.0TLR2, TLR4, TLR3, TLR5
30
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
7.5NOD2, TLR5, TLR3, TLR4, TLR2

Compounds for genes affiliated with Pouchitis

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Compounds related to Pouchitis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1asialo gm1449.7TLR5, TLR2
2arabinogalactan449.5TLR4, TLR2
3glucuronoxylomannan449.5TLR4, TLR2
4hbd2449.5TLR2, TLR4
5lauric acid44 2810.5TLR4, TLR2
6zymosan449.5TLR2, TLR4
7mannan449.5TLR4, TLR2
8docosahexaenoic acid44 28 2411.4TLR2, TLR4
9polymyxin b449.4TLR4, TLR2
10infliximab44 50 1111.4NOD2, TLR4
112,5-oligoadenylate449.4TLR4, TLR3
12glycolipid449.4TLR4, TLR2
13anti-fungal449.4TLR2, TLR4
14ccl344 2810.3TLR4, TLR2
15ifn-alpha449.3TLR3, TLR4
16latex449.2TLR4, TLR2
17palmitate449.2TLR4, TLR2
18simvastatin44 50 61 28 24 1114.1TLR4, TLR2
19diaminopimelic acid449.1NOD2, TLR4, TLR2
20muramyl dipeptide44 2810.1NOD2, TLR4, TLR2
21il 10449.1TLR2, TLR4, NOD2
22mannose449.0NOD2, TLR4, TLR2
23pam3csk4619.0TLR4, TLR2, TLR3
24pam2csk4619.0TLR3, TLR4, TLR2
25tacrolimus44 50 1111.0NOD2, TLR4, TLR2
26poly(i:c)619.0TLR2, TLR4, TLR3
27resiquimod44 6110.0TLR2, TLR4, TLR3
28imiquimod44 61 28 1112.0TLR2, TLR4, TLR3
29polyinosinic-polycytidylic acid449.0TLR3, TLR4, TLR2
30wortmannin448.9TLR3, TLR4, TLR2
31loxoribine44 289.9TLR2, TLR4, TLR5
32agarose448.8TLR4, TLR2
33dexamethasone44 50 28 1111.8TLR2, TLR4, TLR3
34retinoic acid44 249.6TLR2, TLR4, TLR3
35endotoxin448.6NOD2, TLR3, TLR4, TLR2
36nitric oxide44 24 1110.5TLR2, TLR4, TLR3, NOD2
37serine448.4NOD2, TLR3, TLR4, TLR2
38flagellin44 289.4TLR2, TLR4, TLR3, TLR5
39lipoteichoic acid448.4TLR5, TLR3, TLR4, TLR2
40poly(i-c)448.4TLR2, TLR4, TLR3, TLR5
41atp44 289.4TLR5, TLR4, TLR2
42rantes448.4TLR5, TLR3, TLR4, TLR2
43phosphatidylinositol448.4TLR2, TLR4, TLR3, TLR5
44tyrosine448.3TLR5, TLR3, TLR4, TLR2
45peptidoglycan44 289.0NOD2, TLR5, TLR3, TLR4, TLR2

GO Terms for genes affiliated with Pouchitis

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Cellular components related to Pouchitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.9NOD2, TLR3, TLR2
2endosome membraneGO:0100088.8TLR3, TLR4
3integral component of plasma membraneGO:0058878.6TLR3, TLR4, TLR2

Biological processes related to Pouchitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idNameGO IDScoreTop Affiliating Genes
1cellular response to peptidoglycanGO:0712249.9NOD2, TLR2
2negative regulation of interleukin-12 productionGO:0326959.8NOD2, TLR2
3negative regulation of growth of symbiont in hostGO:0441309.8TLR2, NOD2
4response to exogenous dsRNAGO:0433309.6NOD2, TLR3
5defense response to Gram-positive bacteriumGO:0508309.6TLR2, NOD2
6cellular response to lipoteichoic acidGO:0712239.5TLR2, TLR4
7positive regulation of macrophage cytokine productionGO:0609079.5TLR2, TLR4
8positive regulation of interferon-beta biosynthetic processGO:0453599.5TLR4, TLR3
9negative regulation of interleukin-17 productionGO:0327009.5TLR4, TLR2
10positive regulation of tumor necrosis factor biosynthetic processGO:0425359.4TLR2, TLR4
11negative regulation of interferon-gamma productionGO:0326899.4NOD2, TLR4
12pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseGO:0520339.4NOD2, TLR3, TLR2
13microglial cell activation involved in immune responseGO:0022829.4TLR2, TLR3, NOD2
14negative regulation of osteoclast differentiationGO:0456719.4TLR3, TLR4
15negative regulation of tumor necrosis factor productionGO:0327209.4NOD2, TLR4
16lipopolysaccharide-mediated signaling pathwayGO:0316639.3TLR2, TLR4
17toll-like receptor 5 signaling pathwayGO:0341469.3NOD2, TLR5
18positive regulation of nitric oxide biosynthetic processGO:0454299.3TLR4, TLR2
19positive regulation of toll-like receptor signaling pathwayGO:0341239.3TLR5, TLR3, TLR2
20I-kappaB kinase/NF-kappaB signalingGO:0072499.1TLR3, TLR4
21positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.1TLR2, TLR4, NOD2
22toll-like receptor 10 signaling pathwayGO:0341669.1NOD2, TLR5
23positive regulation of interleukin-10 productionGO:0327339.1NOD2, TLR4, TLR2
24positive regulation of JNK cascadeGO:0463309.1NOD2, TLR3, TLR4
25toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.1NOD2, TLR4, TLR2
26toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.1NOD2, TLR4, TLR2
27toll-like receptor 2 signaling pathwayGO:0341349.1TLR2, TLR4, NOD2
28inflammatory responseGO:0069549.0TLR5, TLR3, TLR2
29TRIF-dependent toll-like receptor signaling pathwayGO:0356669.0NOD2, TLR3, TLR4
30MyD88-independent toll-like receptor signaling pathwayGO:0027569.0TLR4, TLR3, NOD2
31I-kappaB phosphorylationGO:0072529.0TLR2, TLR4, TLR3
32toll-like receptor 3 signaling pathwayGO:0341389.0NOD2, TLR3, TLR4
33cellular response to lipopolysaccharideGO:0712229.0TLR5, TLR4
34positive regulation of chemokine productionGO:0327229.0TLR3, TLR4, TLR2
35defense response to bacteriumGO:0427429.0TLR4, TLR3, NOD2
36positive regulation of NF-kappaB import into nucleusGO:0423469.0TLR3, TLR4, TLR2
37positive regulation of interferon-beta productionGO:0327289.0TLR2, TLR4, TLR3
38positive regulation of inflammatory responseGO:0507299.0TLR3, TLR4, TLR2
39positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.0NOD2, TLR3, TLR4
40cellular response to mechanical stimulusGO:0712608.9TLR4, TLR3, TLR5
41positive regulation of interleukin-12 productionGO:0327358.6TLR2, TLR4, TLR3, NOD2
42positive regulation of tumor necrosis factor productionGO:0327608.6NOD2, TLR3, TLR4, TLR2
43positive regulation of interleukin-6 productionGO:0327558.6TLR2, TLR4, TLR3, NOD2
44toll-like receptor 4 signaling pathwayGO:0341428.6TLR2, TLR4, TLR3, NOD2
45positive regulation of NF-kappaB transcription factor activityGO:0510928.6TLR2, TLR4, TLR3, NOD2
46MyD88-dependent toll-like receptor signaling pathwayGO:0027558.5NOD2, TLR5, TLR4, TLR2
47positive regulation of transcription from RNA polymerase II promoterGO:0459448.5TLR2, TLR4, TLR3, NOD2
48positive regulation of interleukin-8 productionGO:0327578.4TLR2, TLR4, TLR3, TLR5
49toll-like receptor signaling pathwayGO:0022248.0NOD2, TLR5, TLR3, TLR4, TLR2
50innate immune responseGO:0450877.9TLR2, TLR4, TLR3, TLR5, NOD2

Molecular functions related to Pouchitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:0428349.2TLR2, NOD2
2lipopolysaccharide receptor activityGO:0018759.1TLR4, TLR2
3receptor activityGO:0048728.6TLR3, TLR4, TLR2
4transmembrane signaling receptor activityGO:0048888.5TLR3, TLR4, TLR2

Products for genes affiliated with Pouchitis

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Sources for Pouchitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet