MCID: PCH007
MIFTS: 47

Pouchitis malady

Rare diseases category

Summaries for Pouchitis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Pouchitis is inflammation of the ileal pouch (an artificial rectum surgically created out of ileal gut... more...

MalaCards: Pouchitis is related to ulcerative colitis and inflammatory bowel disease. An important gene associated with Pouchitis is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Cytosolic sensors of pathogen-associated DNA and IL-17 Family Signaling Pathways. The compounds asialo gm1 and arabinogalactan have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Pouchitis

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50Orphanet, 63UMLS, 37MESH via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Characteristics (Orphanet epidemiological data):

50
pouchitis:
Prevalence: 1-5/10000


Aliases & Descriptions:

pouchitis 50 63


External Ids:

MESH via Orphanet37 D019449
UMLS via Orphanet64 C0376620

Related Diseases for Pouchitis

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18GeneCards, 19GeneDecks
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Diseases related to Pouchitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.1TLR2, TLR3, TLR5, NOD2, TLR4
2inflammatory bowel disease30.5TLR5, TLR4, NOD2, TLR2
3arthritis30.3TLR2, TLR4, TLR3, NOD2
4hepatitis29.9TLR2, TLR3
5hepatitis c29.9TLR3, TLR4, TLR2
6blindness10.3
7crohn's disease10.3
8familial adenomatous polyposis10.3
9cytomegalovirus infection10.3
10sclerosing cholangitis10.2
11adenocarcinoma10.2
12cholangitis10.2
13primary sclerosing cholangitis10.2
14pyoderma gangrenosum10.1
15gastroduodenitis10.1
16pyoderma10.1
17blau syndrome10.1NOD2
18legionnaires' disease10.1TLR5
19colorectal cancer10.1NOD2
20psoriatic arthritis10.0TLR2, NOD2
21measles10.0TLR3, TLR2
22encephalitis10.0TLR3, TLR2
23mastitis10.0TLR4, TLR2
24invasive aspergillosis10.0TLR2, TLR4
25filariasis10.0TLR2, TLR4
26neisseria meningitidis infection10.0TLR2, TLR4
27ankylosing spondylitis10.0TLR4, NOD2
28chorioamnionitis10.0TLR4, TLR2
29aspergillosis10.0TLR4, TLR2
30keratitis10.0TLR2, TLR4
31malt lymphoma10.0TLR4, TLR2
32herpes simplex10.0TLR2, TLR3
33periodontitis10.0TLR2, TLR4
34periodontal disease10.0TLR4, TLR2
35septic shock10.0TLR2, TLR4
36influenza10.0TLR5, TLR3
37psoriasis10.0NOD2, TLR5, TLR2
38allergic asthma10.0TLR2, TLR4
39atopy10.0TLR2, NOD2, TLR4
40atopic dermatitis10.0TLR2, NOD2, TLR4
41deficiency anemia10.0
42iritis10.0
43iron deficiency anemia10.0
44bursitis10.0
45obesity10.0
46spondyloarthropathy10.0
47uveitis10.0
48gardner syndrome10.0
49endotheliitis10.0
50microscopic colitis10.0

Graphical network of the top 20 diseases related to Pouchitis:



Diseases related to pouchitis

Symptoms for Pouchitis

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Drugs & Therapeutics for Pouchitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Pouchitis

Drug clinical trials:

Search ClinicalTrials for Pouchitis

Search NIH Clinical Center for Pouchitis

Search CenterWatch for Pouchitis

Genetic Tests for Pouchitis

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Anatomical Context for Pouchitis

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34MalaCards
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MalaCards organs/tissues related to Pouchitis:

34
Small intestine, Liver, Colon, Testes, T cells, Endothelial

Animal Models for Pouchitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Pouchitis:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.6TLR5, TLR4, TLR2
2MP:00020068.6TLR2, TLR4, TLR3
3MP:00053818.3NOD2, TLR5, TLR4, TLR2
4MP:00053888.2TLR2, TLR4, TLR3, TLR5
5MP:00053708.2TLR2, TLR4, TLR5
6MP:00053858.1TLR2, TLR4, TLR3, TLR5
7MP:00053868.1TLR2, TLR4, TLR3, TLR5
8MP:00053788.1NOD2, TLR5, TLR4, TLR2
9MP:00053848.0NOD2, TLR5, TLR4, TLR2
10MP:00053977.8NOD2, TLR5, TLR3, TLR4, TLR2
11MP:00053877.8TLR2, TLR4, TLR3, TLR5, NOD2
12MP:00053767.7TLR2, TLR4, TLR3, TLR5, NOD2

Publications for Pouchitis

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53PubMed
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Articles related to Pouchitis:

(show top 50)    (show all 322)
idTitleAuthorsYear
1
Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohn's Disease, and Pouchitis: Meta-analysis of Randomized Controlled Trials. (24280877)
2014
2
Infliximab for the treatment of pouchitis. (24303499)
2013
3
Meta-analysis: serological markers and the risk of acute and chronic pouchitis. (23480145)
2013
4
Characteristics of extremely early-onset pouchitis after proctocolectomy with ileal pouch-anal anastomosis. (23254315)
2013
5
Stricture of ileo-anal J pouch anastomosis increased the intensity of pouchitis in an experimental rat model. (23018348)
2012
6
Discrepancy between clinical and histological effects of DHA supplementation in a rat model of pouchitis. (22532147)
2012
7
An open study of maintenance antibiotic therapy for chronic antibiotic-dependent pouchitis: efficacy, complications and outcome. (20041929)
2011
8
Pouchitis and pouch dysfunction. (19944799)
2010
9
Diagnosis and management of pouchitis and ileoanal pouch dysfunction. (20890738)
2010
10
Early diagnosis of bilateral sub-deltoid bursitis using clinic-based ultrasonography in a patient receiving infliximab therapy for ulcerative pouchitis. (18949534)
2010
11
An assessment of bacterial dysbiosis in pouchitis using terminal restriction fragment length polymorphisms of 16S ribosomal DNA from pouch effluent microbiota. (19617766)
2009
12
Re: Adenocarcinoma arising in a background of chronic atrophic pouchitis in an ileoanal pouch for ulcerative colitis. (19302532)
2009
13
Leukocytapheresis for the treatment of active pouchitis: a pilot study. (18648745)
2008
14
Development of pouchitis following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis: A role for serological markers and microbial pattern recognition receptor genes. (21172204)
2008
15
Proliferation of immature plasma cells in pouchitis mucosa in patients with ulcerative colitis. (18452202)
2008
16
On the benefit of probiotics in the management of pouchitis in patients underwent ileal pouch anal anastomosis: a meta-analysis of controlled clinical trials. (17940902)
2008
17
Diagnosis and treatment of pouchitis. (21904509)
2008
18
Portal vein thrombi after ileal pouch-anal anastomosis: its incidence and association with pouchitis. (17593473)
2007
19
Pouchitis. (17948934)
2007
20
Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis. (17007066)
2006
21
Systematic review: the management of pouchitis. (16611268)
2006
22
Probiotic therapy to prevent pouchitis onset. (15793632)
2005
23
Inflammatory bowel disease: a new combination therapy for pouchitis. (15976743)
2005
24
Association between fecal hydrogen sulfide production and pouchitis. (15747080)
2005
25
Diagnostic difficulties in pouchitis--experience from a single institution. (15469209)
2004
26
Human lymphocyte stimulation with pouchitis flora is greater than with flora from a healthy pouch but is suppressed by metronidazole. (15542518)
2004
27
Long-term follow-up after ileoanal pouch procedure: algorithm for diagnosis, classification, and management of pouchitis. (11330575)
2001
28
Increase in cyclooxygenase-2 and nitric oxide-synthase-2 mRNAs in pouchitis without modification of inducible isoenzyme heme-oxygenase-1. (11467644)
2001
29
Association of decreased perfusion of the ileoanal pouch mucosa with early postoperative pouchitis and local septic complications. (11585503)
2001
30
Simple gas chromatography analysis of faecal butyrate: application to patients at risk of pouchitis. (11256793)
2001
31
Colectomy and ileal pouch. Transport and barrier in pouchitis. (11193590)
2000
32
Pouchitis: extracolonic manifestation of ulcerative colitis? (10788837)
1999
33
IgG, albumin, and sCD44 in whole-gut lavage fluid are useful clinical markers for assessing the presence and activity of pouchitis. (10207728)
1999
34
The implications of acute pouchitis on the long-term functional results after restorative proctocolectomy. (9836080)
1998
35
Pouchitis associated with primary cytomegalovirus infection. (9468256)
1998
36
How do you treat refractory pouchitis and when do you decide to remove the pouch? (9589302)
1998
37
Stricture and pouchitis after ileal pouch-anal anastomosis. (9407824)
1997
38
Pouchitis: pathogenesis, diagnosis, and management. (8792143)
1996
39
Fecal bile acids, short-chain fatty acids, and bacteria after ileal pouch-anal anastomosis do not differ in patients with pouchitis. (7628271)
1995
40
p-ANCA and development of pouchitis in ulcerative colitis patients after proctocolectomy and ileoanal pouch anastomosis. (7916418)
1994
41
Pouchitis: result of microbial imbalance? (8200561)
1994
42
Pouchitis--recurrence of the inflammatory bowel disease? (8307476)
1994
43
Pouchitis. (7953327)
1994
44
The pull-through procedure: technical factors in influencing outcome, with emphasis on pouchitis. (8211701)
1993
45
Cyclosporin A retention enemas in refractory distal ulcerative colitis and 'pouchitis'. (8210986)
1993
46
Short-chain fatty acids in pouch contents from patients with and without pouchitis after ileal pouch-anal anastomosis. (1397871)
1992
47
Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis. (2009019)
1991
48
The pelvic ileal reservoir: pathology and pouchitis. (2172847)
1990
49
Topical administration of 5-aminosalicylic acid: a therapeutic proposal for the treatment of pouchitis. (2911318)
1989
50
Pouchitis. (3058838)
1988

Variations for Pouchitis

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Expression for genes affiliated with Pouchitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pouchitis

Search GEO for disease gene expression data for Pouchitis.

Pathways for genes affiliated with Pouchitis

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Sources:
51PathCards, 56Reactome, 31KEGG, 55R&D Systems, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN, 13EMD Millipore, 5Cell Signaling Technology, 62Tocris Bioscience, 58SinoBiological
See all sources

Pathways related to Pouchitis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5TLR3, NOD2
2
Show member pathways
9.3TLR5, TLR2
3
Show member pathways
Immune response MIF in innate immunity response61
9.1TLR4, TLR3
49.1TLR2, TLR4
59.1TLR4, TLR2
69.1TLR4, TLR2
79.1TLR4, TLR2
89.1TLR4, TLR2
9
Show member pathways
9.1TLR2, TLR4
10
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion61
Pathogenic Escherichia coli infection39
9.0TLR5, TLR4
11
Show member pathways
8.7TLR4, TLR3, NOD2
128.7TLR2, TLR4, NOD2
13
Show member pathways
8.6TLR3, TLR4, TLR2
148.6TLR3, TLR4, TLR2
15
Show member pathways
8.6NOD2, TLR5, TLR4
168.5TLR5, TLR4, TLR2
17
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.5TLR2, TLR4, TLR5
18
Show member pathways
8.1TLR2, TLR4, TLR5, NOD2
19
Show member pathways
8.0TLR2, TLR4, TLR3, TLR5
20
Show member pathways
8.0TLR2, TLR4, TLR3, TLR5
21
Show member pathways
8.0TLR2, TLR4, TLR3, TLR5
22
Show member pathways
IL27-mediated signaling events39
8.0TLR2, TLR4, TLR3, TLR5
238.0TLR5, TLR3, TLR4, TLR2
248.0TLR5, TLR3, TLR4, TLR2
25
Show member pathways
8.0TLR5, TLR3, TLR4, TLR2
26
Show member pathways
8.0TLR5, TLR3, TLR4, TLR2
27
Show member pathways
8.0TLR2, TLR4, TLR3, TLR5
28
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.0TLR2, TLR4, TLR3, TLR5
29
Show member pathways
8.0TLR2, TLR4, TLR3, TLR5
30
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
7.5NOD2, TLR5, TLR3, TLR4, TLR2

Compounds for genes affiliated with Pouchitis

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 52PharmGKB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Pouchitis according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1asialo gm1469.7TLR5, TLR2
2arabinogalactan469.5TLR4, TLR2
3glucuronoxylomannan469.5TLR4, TLR2
4hbd2469.5TLR2, TLR4
5lauric acid46 3010.5TLR4, TLR2
6zymosan469.5TLR2, TLR4
7mannan469.5TLR4, TLR2
8docosahexaenoic acid46 30 2511.4TLR2, TLR4
9polymyxin b469.4TLR4, TLR2
10infliximab46 52 1211.4NOD2, TLR4
112,5-oligoadenylate469.4TLR4, TLR3
12glycolipid469.4TLR4, TLR2
13anti-fungal469.4TLR2, TLR4
14ccl346 3010.3TLR4, TLR2
15ifn-alpha469.3TLR3, TLR4
16latex469.2TLR4, TLR2
17palmitate469.2TLR4, TLR2
18simvastatin46 52 62 30 25 1214.1TLR4, TLR2
19diaminopimelic acid469.1NOD2, TLR4, TLR2
20muramyl dipeptide46 3010.1NOD2, TLR4, TLR2
21il 10469.1TLR2, TLR4, NOD2
22mannose469.0NOD2, TLR4, TLR2
23pam3csk4629.0TLR4, TLR2, TLR3
24pam2csk4629.0TLR3, TLR4, TLR2
25tacrolimus46 52 1211.0NOD2, TLR4, TLR2
26poly(i:c)629.0TLR2, TLR4, TLR3
27resiquimod46 6210.0TLR2, TLR4, TLR3
28imiquimod46 62 30 1212.0TLR2, TLR4, TLR3
29polyinosinic-polycytidylic acid469.0TLR3, TLR4, TLR2
30wortmannin468.9TLR3, TLR4, TLR2
31loxoribine46 309.9TLR2, TLR4, TLR5
32agarose468.8TLR4, TLR2
33dexamethasone46 52 30 1211.8TLR2, TLR4, TLR3
34retinoic acid46 259.6TLR2, TLR4, TLR3
35endotoxin468.6NOD2, TLR3, TLR4, TLR2
36nitric oxide46 25 1210.5TLR2, TLR4, TLR3, NOD2
37serine468.4NOD2, TLR3, TLR4, TLR2
38flagellin46 309.4TLR2, TLR4, TLR3, TLR5
39lipoteichoic acid468.4TLR5, TLR3, TLR4, TLR2
40poly(i-c)468.4TLR2, TLR4, TLR3, TLR5
41atp46 309.4TLR5, TLR4, TLR2
42rantes468.4TLR5, TLR3, TLR4, TLR2
43phosphatidylinositol468.4TLR2, TLR4, TLR3, TLR5
44tyrosine468.3TLR5, TLR3, TLR4, TLR2
45peptidoglycan46 309.0NOD2, TLR5, TLR3, TLR4, TLR2

GO Terms for genes affiliated with Pouchitis

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Sources:
17Gene Ontology
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Cellular components related to Pouchitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.9NOD2, TLR3, TLR2
2endosome membraneGO:0100088.8TLR3, TLR4
3integral component of plasma membraneGO:0058878.6TLR3, TLR4, TLR2

Biological processes related to Pouchitis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idNameGO IDScoreTop Affiliating Genes
1cellular response to peptidoglycanGO:0712249.9NOD2, TLR2
2negative regulation of interleukin-12 productionGO:0326959.8NOD2, TLR2
3negative regulation of growth of symbiont in hostGO:0441309.8TLR2, NOD2
4response to exogenous dsRNAGO:0433309.6NOD2, TLR3
5defense response to Gram-positive bacteriumGO:0508309.6TLR2, NOD2
6cellular response to lipoteichoic acidGO:0712239.5TLR2, TLR4
7positive regulation of macrophage cytokine productionGO:0609079.5TLR2, TLR4
8positive regulation of interferon-beta biosynthetic processGO:0453599.5TLR4, TLR3
9negative regulation of interleukin-17 productionGO:0327009.5TLR4, TLR2
10positive regulation of tumor necrosis factor biosynthetic processGO:0425359.4TLR2, TLR4
11negative regulation of interferon-gamma productionGO:0326899.4NOD2, TLR4
12pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseGO:0520339.4NOD2, TLR3, TLR2
13microglial cell activation involved in immune responseGO:0022829.4TLR2, TLR3, NOD2
14negative regulation of osteoclast differentiationGO:0456719.4TLR3, TLR4
15negative regulation of tumor necrosis factor productionGO:0327209.4NOD2, TLR4
16lipopolysaccharide-mediated signaling pathwayGO:0316639.3TLR2, TLR4
17toll-like receptor 5 signaling pathwayGO:0341469.3NOD2, TLR5
18positive regulation of nitric oxide biosynthetic processGO:0454299.3TLR4, TLR2
19positive regulation of toll-like receptor signaling pathwayGO:0341239.3TLR5, TLR3, TLR2
20I-kappaB kinase/NF-kappaB signalingGO:0072499.1TLR3, TLR4
21positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.1TLR2, TLR4, NOD2
22toll-like receptor 10 signaling pathwayGO:0341669.1NOD2, TLR5
23positive regulation of interleukin-10 productionGO:0327339.1NOD2, TLR4, TLR2
24positive regulation of JNK cascadeGO:0463309.1NOD2, TLR3, TLR4
25toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.1NOD2, TLR4, TLR2
26toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.1NOD2, TLR4, TLR2
27toll-like receptor 2 signaling pathwayGO:0341349.1TLR2, TLR4, NOD2
28inflammatory responseGO:0069549.0TLR5, TLR3, TLR2
29TRIF-dependent toll-like receptor signaling pathwayGO:0356669.0NOD2, TLR3, TLR4
30MyD88-independent toll-like receptor signaling pathwayGO:0027569.0TLR4, TLR3, NOD2
31I-kappaB phosphorylationGO:0072529.0TLR2, TLR4, TLR3
32toll-like receptor 3 signaling pathwayGO:0341389.0NOD2, TLR3, TLR4
33cellular response to lipopolysaccharideGO:0712229.0TLR5, TLR4
34positive regulation of chemokine productionGO:0327229.0TLR3, TLR4, TLR2
35defense response to bacteriumGO:0427429.0TLR4, TLR3, NOD2
36positive regulation of NF-kappaB import into nucleusGO:0423469.0TLR3, TLR4, TLR2
37positive regulation of interferon-beta productionGO:0327289.0TLR2, TLR4, TLR3
38positive regulation of inflammatory responseGO:0507299.0TLR3, TLR4, TLR2
39positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.0NOD2, TLR3, TLR4
40cellular response to mechanical stimulusGO:0712608.9TLR4, TLR3, TLR5
41positive regulation of interleukin-12 productionGO:0327358.6TLR2, TLR4, TLR3, NOD2
42positive regulation of tumor necrosis factor productionGO:0327608.6NOD2, TLR3, TLR4, TLR2
43positive regulation of interleukin-6 productionGO:0327558.6TLR2, TLR4, TLR3, NOD2
44toll-like receptor 4 signaling pathwayGO:0341428.6TLR2, TLR4, TLR3, NOD2
45positive regulation of NF-kappaB transcription factor activityGO:0510928.6TLR2, TLR4, TLR3, NOD2
46MyD88-dependent toll-like receptor signaling pathwayGO:0027558.5NOD2, TLR5, TLR4, TLR2
47positive regulation of transcription from RNA polymerase II promoterGO:0459448.5TLR2, TLR4, TLR3, NOD2
48positive regulation of interleukin-8 productionGO:0327578.4TLR2, TLR4, TLR3, TLR5
49toll-like receptor signaling pathwayGO:0022248.0NOD2, TLR5, TLR3, TLR4, TLR2
50innate immune responseGO:0450877.9TLR2, TLR4, TLR3, TLR5, NOD2

Molecular functions related to Pouchitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:0428349.2TLR2, NOD2
2lipopolysaccharide receptor activityGO:0018759.1TLR4, TLR2
3receptor activityGO:0048728.6TLR3, TLR4, TLR2
4transmembrane signaling receptor activityGO:0048888.5TLR3, TLR4, TLR2

Products for genes affiliated with Pouchitis

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  • Antibodies
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Sources for Pouchitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet