Aliases & Classifications for Pouchitis

Aliases & Descriptions for Pouchitis:

Name: Pouchitis 56 52 69

Characteristics:

Orphanet epidemiological data:

56
pouchitis
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Orphanet 56 ORPHA217067
MESH via Orphanet 43 D019449
UMLS via Orphanet 70 C0376620

Summaries for Pouchitis

MalaCards based summary : Pouchitis is related to sclerosing cholangitis and colitis. An important gene associated with Pouchitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ciprofloxacin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and endothelial, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Wikipedia : 71 Pouchitis is inflammation of the ileal pouch (an artificial rectum surgically created out of ileal gut... more...

Related Diseases for Pouchitis

Diseases related to Pouchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
id Related Disease Score Top Affiliating Genes
1 sclerosing cholangitis 29.8 CXCL8 LTF
2 colitis 10.6
3 ulcerative colitis 10.6
4 pigmented nodular adrenocortical disease, primary, 4 10.2 NOD2 TLR4
5 newcastle disease 10.2 IL1RN NOD2
6 crohn's colitis 10.2 NOD2 TLR4
7 nephropathy familial with hyperuricemia 10.2 IL1RN TLR4
8 mikulicz disease 10.1 LTF TLR4
9 celiac disease 10.1 IL1RN NOD2
10 mucositis 10.1
11 acute myeloid leukemia with recurrent genetic anomaly 10.1 IL10 NOD2
12 gonococcal endophthalmia 10.1 IL10 IL1RN
13 oral cavity carcinoma in situ 10.1 IL10 IL1RN
14 megaloblastic anemia 10.1 IL10 TLR4
15 inflammatory bowel disease 10.1
16 rickettsialpox 10.1 IL10 TLR4
17 abnormal retinal correspondence 10.1 IL10 TLR4
18 usher syndrome, type 2a 10.1 IL10 TLR4
19 acute gonococcal cystitis 10.1 CXCL8 NOD2
20 amyotrophic lateral sclerosis type 14 10.1 CXCL8 NOD2
21 malignant histiocytosis 10.1 CXCL8 NOD2
22 histiocytoma 10.1 CXCL8 NOD2
23 stomatitis 10.0 CXCL8 IL1RN
24 mansonelliasis 10.0 IL10 TLR4
25 crohn's disease 10.0
26 orthostatic proteinuria 10.0 CXCL8 IL1RN
27 psychotic disorder 10.0 CXCL8 LTF
28 retinal vascular disease 10.0 CXCL8 LTF
29 scleroderma, familial progressive 10.0 CXCL8 LTF
30 endobronchial leiomyoma 10.0 IL1RN NOD2
31 handl syndrome 10.0 CXCL8 LTF
32 larynx leiomyoma 10.0 CXCL8 TLR4
33 omsk hemorrhagic fever 10.0 CXCL8 TLR4
34 calpainopathy 10.0 CXCL8 IL1RN
35 nasal cavity cancer 10.0 CXCL8 IL1RN
36 lateral cystocele 10.0 CXCL8 TLR4
37 appendiceal l-cell glucagon-like peptide producing tumor 10.0 CXCL8 TLR4
38 neuropathy 10.0 CXCL8 TLR4
39 skin conditions 10.0 CXCL8 IL1RN
40 ectothrix infectious disease 10.0 CXCL8 TLR4
41 ovarian cystic teratoma 10.0 CXCL8 TLR4
42 conidiobolomycosis 10.0 CXCL8 IL10
43 inflammatory bowel disease 20 10.0 CXCL8 IL10
44 microglandular adenosis of breast 10.0 CXCL8 IL10
45 neonatal hypoxic and ischemic brain injury 10.0 CXCL8 IL10
46 hidradenitis suppurativa 10.0 CXCL8 IL10
47 cowpox 10.0 CXCL8 IL1RN
48 childhood electroclinical syndrome 10.0 CXCL8 IL10
49 middle lobe syndrome 10.0 CXCL8 IL10
50 dengue hemorrhagic fever 10.0 IL10 TLR4

Graphical network of the top 20 diseases related to Pouchitis:



Diseases related to Pouchitis

Symptoms & Phenotypes for Pouchitis

GenomeRNAi Phenotypes related to Pouchitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.36 NOD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.36 IL10
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.36 IL10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.36 NOD2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.36 IL10
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 IL10
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.36 IL10
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.36 IL10 NOD2 TLR4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.36 NOD2

Drugs & Therapeutics for Pouchitis

Drugs for Pouchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
2
Vedolizumab Approved Phase 4 943609-66-3
3
Certolizumab pegol Approved Phase 4 428863-50-7
4 Antirheumatic Agents Phase 4,Phase 3
5 Gastrointestinal Agents Phase 4,Phase 3
6 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Topoisomerase Inhibitors Phase 4
9 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
10 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
11 Immunosuppressive Agents Phase 4,Phase 3
12
Adalimumab Approved Phase 3 331731-18-1 16219006
13 Anti-Inflammatory Agents Phase 3
14
Alicaforsen Phase 3 185229-68-9 16197724
15 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
16
Menthol Approved Phase 2 2216-51-5 16666
17
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
18 Antitubercular Agents Phase 2
19 Defensins
20 Immunoglobulins
21 Antibodies
22 Acidophilus Nutraceutical

Interventional clinical trials:

(show all 22)
id Name Status NCT ID Phase
1 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
2 Phase 4 Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis Recruiting NCT02790138 Phase 4
3 EUS Evaluation of Perianal and Peri-rectal Fistulizing Crohn's Disease With CERTOLIZUMAB Treatment Terminated NCT01582568 Phase 4
4 Adalimumab in the Treatment of Chronic Pouchitis Completed NCT01670240 Phase 3
5 Clinical Approaches to Ileal Pouch Dysfunction Completed NCT00293553 Phase 3
6 Randomized Study of Topical Alicaforsen Enema in Antibiotic Refractory Pouchitis Recruiting NCT02525523 Phase 3
7 To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis Completed NCT02201186 Phase 2
8 Safety and Efficacy of AST-120 in the Treatment of Pouchitis Completed NCT00583076 Phase 2
9 FMT in Ulcerative Colitis-Associated Pouchitis Recruiting NCT02049502 Phase 2
10 Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP) Recruiting NCT02782325 Phase 1, Phase 2
11 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2
12 Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis Terminated NCT00583531 Phase 2
13 Study of Sc-FOS for Pouchitis Prevention Active, not recruiting NCT02203955 Phase 1
14 The Interaction Between Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis Unknown status NCT01202396
15 Clinical Outcome After Close Rectal Ileo Pouch Anal Anastomosis for Colitis Ulcerosa(CU) Unknown status NCT01111708
16 Surgical Reconstruction in Ulcerative Colitis With Primary Sclerosing Cholangitis Completed NCT01798953
17 Characterization of Disease Related Changes in Inflammatory Bowel Disease Using Fecal Metabolite Profiling Completed NCT01666717
18 Microbiota and Immune microEnvironment in Pouchitis Recruiting NCT03136419
19 Nutritional Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With IPAA Recruiting NCT02828410
20 Fecal Microbiota Transplant (FMT) for Pouchitis Active, not recruiting NCT02428361 Early Phase 1
21 Corrona Inflammatory Bowel Disease (IBD) Registry Enrolling by invitation NCT03162549
22 MRI in Normal Ileal Pouches, and a Feasibility Study of Dynamic MRI Enema and Defaecating MRI Pouchography Not yet recruiting NCT02925260

Search NIH Clinical Center for Pouchitis

Genetic Tests for Pouchitis

Anatomical Context for Pouchitis

MalaCards organs/tissues related to Pouchitis:

39
Small Intestine, Liver, Endothelial, Neutrophil, T Cells, Prostate, Colon

Publications for Pouchitis

Articles related to Pouchitis:

(show top 50) (show all 392)
id Title Authors Year
1
Efficacy of Vedolizumab in Patients with Antibiotic and Anti-tumor Necrosis Alpha Refractory Pouchitis. ( 27930413 )
2017
2
Tripterygium wilfordii polyglycosidium ameliorates pouchitis induced by dextran sulfate sodium in rats. ( 27988458 )
2017
3
Pouchitis after ileal pouch-anal anastomosis in ulcerative colitis: Diagnosis, management, risk factors, and incidence. ( 27681447 )
2017
4
Short article: Successful faecal coliform sensitivity-based oral ertapenem therapy for chronic antibiotic-refractory pouchitis: a case series. ( 26657456 )
2016
5
The prevalence of chronic peri-pouch sepsis in patients treated for antibiotic-dependent or refractory primary idiopathic pouchitis. ( 27688067 )
2016
6
Immunoglobulin G4 (IgG4)-associated pouchitis - Part of IgG4 related disease? A case series and review of the literature. ( 27038705 )
2016
7
Pouchitis Associated With Pelvic Radiation for Prostate Cancer. ( 27807581 )
2016
8
Fecal Microbiota Transfer in Patients With Chronic Antibiotic-Refractory Pouchitis. ( 27018122 )
2016
9
Endoluminal calprotectin measurement in assessment of pouchitis and a new index of disease activity: a pilot study. ( 26901424 )
2016
10
Alicaforsen, an antisense inhibitor of ICAM-1, as treatment for chronic refractory pouchitis after proctocolectomy: A case series. ( 26966529 )
2016
11
Pouchitis Is a Common Complication in Patients With FamilialA Adenomatous Polyposis Following Ileal Pouch-Anal Anastomosis. ( 27085760 )
2016
12
Patient-Specific Bacteroides Genome Variants in Pouchitis. ( 27935837 )
2016
13
Pouchitis in Pediatric Ulcerative Colitis Patients After Ileal Pouch Anal Anastomosis. ( 27602702 )
2016
14
Secondary pouchitis in a pediatric patient successfully treated by salvage surgery. ( 27097567 )
2016
15
Predictors of Pouchitis After Ileal Pouch-Anal Anastomosis in Children. ( 27243421 )
2016
16
Campylobacter Pouchitis Mimicking the Appearance of Crohn's Disease. ( 27555972 )
2016
17
Reply to a Letter to the Editor Regarding the Original Article, Predictors of Pouchitis After Ileal Pouch-Anal Anastomosis in Children. ( 27574882 )
2016
18
The current place of probiotics and prebiotics in the treatment of pouchitis. ( 27048898 )
2016
19
Review article: the pathogenesis of pouchitis. ( 27554912 )
2016
20
Fecal microbiota in pouchitis and ulcerative colitis. ( 27833384 )
2016
21
Role of intestinal flora imbalance in pathogenesis of pouchitis. ( 27569889 )
2016
22
Alterations of Enteric Microbiota in Patients with a Normal Ileal Pouch Are Predictive of Pouchitis. ( 27613294 )
2016
23
Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm. ( 28008631 )
2016
24
Methodological Quality Assessment of Meta-Analyses and Systematic Reviews of Probiotics in Inflammatory Bowel Disease and Pouchitis. ( 28005973 )
2016
25
Inflammatory pouch disease: The spectrum of pouchitis. ( 26269664 )
2015
26
Specific members of the predominant gut microbiota predict pouchitis following colectomy and IPAA in UC. ( 26423113 )
2015
27
Ursodeoxycholic Acid Inhibits Clostridium difficile Spore Germination and Vegetative Growth, and Prevents the Recurrence of Ileal Pouchitis Associated With the Infection. ( 26485102 )
2015
28
P013. Characterization of enterochromaffin cells in pouchitis after proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. ( 25718321 )
2015
29
Clinical Features of Refractory Pouchitis with Penetrating Lesions and the Efficacy of Infliximab Treatment for Patients with Ulcerative Colitis after Restorative Proctocolectomy. ( 26343749 )
2015
30
Consecutive Monitoring of Fecal Calprotectin and Lactoferrin for the Early Diagnosis and Prediction of Pouchitis after Restorative Proctocolectomy for Ulcerative Colitis. ( 25916224 )
2015
31
Serial Fecal Calprotectin and Lactoferrin Measurements for Early Diagnosis of Pouchitis After Proctocolectomy for Ulcerative Colitis: Is Pouchoscopy No Longer Needed? ( 26052770 )
2015
32
Use of Biologics in Pouchitis: A Systematic Review. ( 26084005 )
2015
33
Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis. ( 26319238 )
2015
34
Successful treatment of chronic Pouchitis utilizing fecal microbiota transplantation (FMT): a case report. ( 26525055 )
2015
35
Role of Probiotics in Crohn's Disease and in Pouchitis. ( 26447964 )
2015
36
The therapeutic potential of antibiotics and probiotics in the treatment of pouchitis. ( 26202437 )
2015
37
P116. Serologic and genetic markers may predict the development of chronic pouchitis after pouch surgery in ulcerative colitis patients. ( 25717575 )
2015
38
Variable alterations of the microbiota, without metabolic or immunological change, following faecal microbiota transplantation in patients with chronic pouchitis. ( 26264409 )
2015
39
Autoimmune features are associated with chronic antibiotic-refractory pouchitis. ( 25437817 )
2015
40
P082. The relationship between onset days and clinical characteristics of pouchitis after ileal pouch-anal anastomosis in Ulcerative Colitis. ( 25717539 )
2015
41
The effect of Clostridium butyricum MIYAIRI on the prevention of pouchitis and alteration of the microbiota profile in patients with ulcerative colitis. ( 26510664 )
2015
42
FK506-Binding Protein 5 mRNA Levels in Ileal Mucosa Are Associated with Pouchitis in Patients with Ulcerative Colitis. ( 25596721 )
2015
43
DOP005. Large bowel mucosal dysplasia in the original specimen influences on severity of pouchitis and higher risk of J-pouch dysplasia. ( 25717721 )
2015
44
DOP053. Risk factors of pouchitis after ileal pouch-anal anastomosis in ulcerative colitis: Multivariate analysis. ( 25718266 )
2015
45
Frequency, Clinical Features and Factors Associated with Pouchitis after Proctocolectomy with Ileo-Pouch-Anal Anastomosis in Patients with Ulcerative Colitis: A Latin-American Country Retrospective-Cohort Study. ( 26609703 )
2015
46
DOP086. Enteric micriobiota alterations in patients with a normal ileal pouch may be predictive of pouchitis. ( 25718302 )
2015
47
Male Gender Is Associated with a High Risk for Chronic Antibiotic-Refractory Pouchitis and Ileal Pouch Anastomotic Sinus. ( 26446071 )
2015
48
Serum alpha-1 antitrypsin: a noninvasive marker of pouchitis. ( 25659085 )
2015
49
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( 26593456 )
2015
50
Incidence and Severity of Prepouch Ileitis: A Distinct Disease Entity or a Manifestation of Refractory Pouchitis? ( 26383915 )
2015

Variations for Pouchitis

Expression for Pouchitis

Search GEO for disease gene expression data for Pouchitis.

Pathways for Pouchitis

Pathways related to Pouchitis according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CXCL8 IL10 IL1RN LTF NOD2 TLR4
2
Show member pathways
12.94 CXCL8 IL10 IL1RN NOD2
3
Show member pathways
12.54 CXCL8 IL1RN NOD2 TLR4
4
Show member pathways
12.19 IL10 NOD2 TLR4
5 11.8 IL10 NOD2 TLR4
6 11.71 CXCL8 IL10 IL1RN
7 11.42 CXCL8 IL10 TLR4
8 11.38 IL10 TLR4
9 11.32 CXCL8 NOD2
10 11.24 CXCL8 TLR4
11 11.21 CXCL8 IL10 TLR4
12 11 IL10 TLR4
13 10.82 CXCL8 IL10 IL1RN
14 10.49 CXCL8 IL10 TLR4

GO Terms for Pouchitis

Biological processes related to Pouchitis according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.78 LTF NOD2 TLR4
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.65 LTF NOD2 TLR4
3 immune response GO:0006955 9.62 CXCL8 IL10 IL1RN TLR4
4 response to glucocorticoid GO:0051384 9.61 IL10 IL1RN
5 regulation of inflammatory response GO:0050727 9.6 NOD2 TLR4
6 positive regulation of JNK cascade GO:0046330 9.59 NOD2 TLR4
7 defense response to Gram-negative bacterium GO:0050829 9.58 LTF TLR4
8 positive regulation of tumor necrosis factor production GO:0032760 9.58 NOD2 TLR4
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.58 LTF NOD2 TLR4
10 positive regulation of interleukin-6 production GO:0032755 9.57 NOD2 TLR4
11 negative regulation of tumor necrosis factor production GO:0032720 9.56 IL10 TLR4
12 negative regulation of interferon-gamma production GO:0032689 9.55 IL10 TLR4
13 positive regulation of interleukin-8 production GO:0032757 9.54 NOD2 TLR4
14 cellular response to lipopolysaccharide GO:0071222 9.54 CXCL8 IL10 TLR4
15 negative regulation of interleukin-6 production GO:0032715 9.52 IL10 TLR4
16 positive regulation of interleukin-10 production GO:0032733 9.51 NOD2 TLR4
17 positive regulation of stress-activated MAPK cascade GO:0032874 9.49 NOD2 TLR4
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.46 NOD2 TLR4
19 response to molecule of bacterial origin GO:0002237 9.43 CXCL8 IL10
20 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.26 IL10 IL1RN
21 inflammatory response GO:0006954 9.26 CXCL8 IL10 IL1RN TLR4
22 positive regulation of MHC class II biosynthetic process GO:0045348 9.16 IL10 TLR4
23 defense response to bacterium GO:0042742 8.92 IL10 LTF NOD2 TLR4

Molecular functions related to Pouchitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.96 LTF TLR4
2 cytokine activity GO:0005125 8.8 CXCL8 IL10 IL1RN

Sources for Pouchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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