MCID: PCH007
MIFTS: 40

Pouchitis malady

Summaries for Pouchitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Pouchitis is inflammation of the ileal pouch (an artificial rectum surgically created out of ileal gut... more...

MalaCards: Pouchitis is related to ulcerative colitis and inflammatory bowel disease. An important gene associated with Pouchitis is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are MIF Action Through Endocytic Pathway and Trafficking and processing of endosomal TLR. The compounds superoxide and cycloheximide have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and skeleton.

Aliases & Classifications for Pouchitis

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48Orphanet, 60UMLS, 35MESH via Orphanet, 61UMLS via Orphanet
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Characteristics (Orphanet epidemiological data):

48
pouchitis:
Prevalence: 1-5/10000


Aliases & Descriptions:

pouchitis 48 60


External Ids:

MESH via Orphanet35 D019449
UMLS via Orphanet61 C0376620

Related Diseases for Pouchitis

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17GeneCards, 18GeneDecks
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Diseases related to Pouchitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1ulcerative colitis31.2NOD2, NOS2, MMP1, IL1R1, IL1RN, IL10
2inflammatory bowel disease30.5NOD2, NOS2, MMP1, IL1R1, IL1RN, IL10
3crohn's disease30.4NOD2, MPO
4arthritis30.3NOD2, NOS2, MMP1, IL1R1, IL1RN, IL10
5adenocarcinoma30.2LGALS3, NOS2
6pyoderma gangrenosum30.1NOD2
7obesity29.9STAT1, TLR2
8uveitis29.8NOD2, IL1R1, IL10, CD14
9deficiency anemia29.8EPO, XDH, TF
10iron deficiency anemia29.8EPO, LTF, TF
11hepatitis29.8LTF, XDH, STAT1, TF
12hepatitis c29.8MMP1, IL10, LTF, STAT1, TF, TLR3
13familial adenomatous polyposis10.3
14sclerosing cholangitis10.2
15cholangitis10.2
16gastroduodenitis10.1
17pyoderma10.1
18lupus erythematosus10.0TLR9
19bronchiolitis10.0TLR4
20spondylitis10.0NOD2
21familial mediterranean fever10.0NOD2
22myocardial infarction10.0CD14
23insulin resistance10.0TLR4
24pyelonephritis10.0TLR4
25bronchopulmonary dysplasia10.0IL1RN
26duodenal ulcer10.0IL1RN
27ovarian cancer10.0TLR3
28thyroid cancer10.0LGALS3
29dermatomyositis10.0IL1RN
30glaucoma10.0MMP1
31dilated cardiomyopathy10.0MMP1
32peptic ulcer10.0CD14
33silicosis10.0IL1RN
34pleurisy10.0MPO
35arteriosclerosis10.0CD14
36prostatitis10.0LTF
37sjogren's syndrome10.0LTF
38candidiasis10.0LTF
39dermatitis10.0NOD2, TLR9
40meningitis10.0TLR2
41leprosy10.0TLR2
42irritable bowel syndrome10.0LTF
43vitiligo10.0XDH
44skin disease10.0MPO
45gastric ulcer10.0TLR2
46polymyositis10.0IL1RN
47essential hypertension10.0XDH
48hemochromatosis10.0TF
49chronic mucocutaneous candidiasis10.0STAT1
50polymyalgia rheumatica10.0IL1RN

Graphical network of the top 20 diseases related to Pouchitis:



Diseases related to pouchitis

Clinical Features for Pouchitis

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Drugs & Therapeutics for Pouchitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pouchitis

Drug clinical trials:

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Search NIH Clinical Center for Pouchitis

Search CenterWatch for Pouchitis

Genetic Tests for Pouchitis

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Anatomical Context for Pouchitis

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Animal Models for Pouchitis or affiliated genes

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36MGI
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Publications for Pouchitis

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Genetic Variations for Pouchitis

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Expression for genes affiliated with Pouchitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pouchitis

Search GEO for disease gene expression data for Pouchitis.

Pathways for genes affiliated with Pouchitis

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 4Cell Signaling Technology, 55SinoBiological, 59Tocris Bioscience
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Pathways related to Pouchitis according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CD14, TLR4
210.1TLR3, TLR9
310.0TLR2, TLR4
4
Hide members
9.9TLR4, TLR3, CD14
5
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
9.9TLR4, TLR3, CD14
6
Development Slit-Robo signaling
Hide members
9.9CD14, TLR5, TLR4
79.9TLR4, CD14, IL1R1
89.8TLR4, TLR2, TLR9
9
Hide members
9.7STAT1, TLR2, TLR4
109.7TLR4, IRAK3, CD14, IL1R1
11
Hide members
9.7IRAK3, IL1RN, IL1R1, NOD2
12
Hide members
9.6TLR5, TLR9, TLR3, IL1R1
139.6STAT1, NOS2, LGALS3
149.6TLR4, CD14, IL10
159.6CD14, EPO, IL1R1
16
Hide members
9.6NOD2, IL1R1, IL1RN, STAT1
17
Hide members
9.6NOD2, IL1R1, IL1RN, STAT1
189.5CD14, TLR5, TLR2, TLR4
199.5CD14, MPO, TLR2, TLR4
209.5TLR4, TLR5, CD14, NOS2
219.5TLR4, IL1R1, NOS2, LGALS3
229.4TLR4, TLR2, TLR9, TLR3, IRAK3
239.3TLR4, TLR2, TLR5, TLR9, TLR3
24
Hide members
9.3TLR3, TLR9, TLR5, TLR2, TLR4
25
Hide members
9.3TLR4, TLR2, TLR5, STAT1, NOD2
26
Hide members
9.3STAT1, TLR3, TLR9, TLR2, TLR4
279.3IRAK3, MPO, IL10, LGALS3
289.2NOS2, EPO, TF
299.2NOS2, IL10, CD14, TLR4
309.2TLR4, TLR2, TLR5, TLR9, IRAK3, CD14
319.1TLR4, TF, EPO, NOS2
32
Hide members
9.0TLR4, TLR2, TLR5, TLR9, TLR3, CD14
33
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8.9TLR4, TLR2, TLR5, TLR9, TLR3, IRAK3
34
Hide members
8.8TLR4, TLR2, TLR5, TLR9, TLR3, STAT1
358.8TLR4, TLR2, TLR5, TLR9, TLR3, STAT1
36
Development PDGF signaling via STATs and NF-kB
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8.8NOS2, IL10, CD14, MPO, STAT1
37
Hide members
8.8TLR4, TLR3, IRAK3, STAT1, CD14, IL1R1
38
Hide members
8.7TLR4, TLR2, TLR5, TLR9, TLR3, CD14
39
Hide members
8.7TLR4, TLR2, TLR5, TLR9, TLR3, IRAK3
408.6TLR4, TLR2, CD14, IL10, IL1R1, NOS2
41
Hide members
8.6TLR4, TLR2, TLR5, TLR9, TLR3, STAT1
42
Hide members
8.4TLR4, TLR2, TLR5, TLR9, TLR3, IRAK3
43
Hide members
8.4TLR4, TLR2, TLR5, TLR9, TLR3, STAT1
44
Immune response Bacterial infections in normal airways
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8.4NOS2, TLR4, TLR2, TLR5, STAT1, CD14
458.2TLR4, TLR2, TLR9, STAT1, CD14, IL10
46
Hide members
8.1TLR4, TLR2, TLR5, TLR9, TLR3, IRAK3
47
Hide members
7.9TLR4, TLR2, TLR5, TLR9, TLR3, STAT1

Compounds for genes affiliated with Pouchitis

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 2BitterDB, 49PharmGKB
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Compounds related to Pouchitis according to GeneCards/GeneDecks:

(show top 50)    (show all 200)
idCompoundScoreTop Affiliating Genes
1superoxide44 2411.3STAT1, LTF
2cycloheximide4410.2TLR2, STAT1
3endotoxin449.9TLR3, IRAK3, STAT1, LTF
4indomethacin44 59 28 1112.9LTF, IL1R1
5loxoribine44 2810.9TLR2, TLR5, TLR9, TLR4
6hydrocortisone44 2 59 1112.9MMP1, EPO, LTF
7resiquimod44 5910.8TLR2, TLR4, TLR3, TLR9
8muramyl dipeptide44 2810.8NOD2, CD14, TLR4, TLR2
9prednisolone44 28 1111.8MMP1, IL1R1, CD14, MPO, NOD2
10diphenyleneiodonium449.6IL1R1, XDH, MPO
11glucuronoxylomannan449.5TLR2, TLR4, IL10, CD14
12flagellin44 2810.5TLR2, TLR4, TLR5, TLR3, TLR9, STAT1
13carbohydrates449.5CD14, TF, IL1RN, TLR4
14rantes449.5TLR4, TLR2, TLR5, STAT1, IL1R1, CD14
15poly(i-c)449.5STAT1, TLR3, TLR9, TLR5, TLR2, TLR4
16dexamethasone44 49 28 1112.4IL1R1, LTF, TLR3, TLR2, TLR4, CD14
17zymosan449.3CD14, IL1RN, TLR4, LTF, TLR2, MPO
18imiquimod44 28 59 1112.3TLR2, TLR3, STAT1, IL10, TLR4
19infliximab44 49 1111.3MMP1, NOD2, IL1RN, IL10, TLR4, IL1R1
20cyclosporin a44 28 5911.3MMP1, TF, CD14, IL1R1, STAT1, LTF
21latex449.2TLR4, LTF, LGALS3, TLR2, CD14, IL1RN
22mannose449.2IL1RN, LGALS3, NOD2, TLR4, TLR2, LTF
23il 10449.2IL10, TLR4, IL1R1, TLR2, IL1RN, NOD2
24h2o2449.1MMP1, IL1R1, IL1RN, LTF, MPO, LGALS3
25polymyxin b449.1TLR2, IL10, IL1RN, LTF, CD14, TLR4
26chloroquine44 2 49 28 1113.0IL10, TLR4, TLR9, TF, IL1RN, IL1R1
27deferoxamine44 1110.0TF, LTF, EPO, STAT1, XDH
28vitamin d448.9LGALS3, IL10, CD14, TLR2, STAT1, IL1R1
29iron44 249.9TF, IL1R1, EPO, XDH, LTF
30pentoxifylline44 119.8IL1RN, IL1R1, MPO, MMP1, LTF, IL10
31polyinosinic-polycytidylic acid448.8IL10, NOS2, TLR2, TLR4, TLR3, STAT1
32fibrinogen448.7LGALS3, IL1R1, IL1RN, CD14, LTF, TF
33ribavirin44 49 1110.6IL10, EPO, STAT1, TF, MMP1, LTF
34lipoteichoic acid448.6IL1RN, IL1R1, IL10, CD14, TLR3, TLR4
35calcitriol44 59 11 2411.5IL10, TLR4, TLR2, STAT1, MMP1, EPO
36peptidoglycan44 289.4TLR3, IL1RN, CD14, TLR9, TLR5, TLR2
37sb 20358044 599.4STAT1, IL10, IL1RN, IL1R1, MMP1, NOS2
38oxygen44 249.4EPO, NOS2, LGALS3, XDH, MPO, TLR2
39serine448.4STAT1, TLR3, NOD2, IL1RN, IL1R1, MMP1
40histamine44 28 2410.3TLR2, TLR4, IL1RN, IL10, CD14, LTF
41creatinine448.3IL1RN, EPO, CD14, LTF, TF, MMP1
42paraffin448.3CD14, MPO, LTF, IL10, IL1R1, MMP1
43n acetylcysteine448.3MMP1, LTF, TLR4, TF, STAT1, MPO
44phosphatidylinositol448.2IL1R1, EPO, CD14, STAT1, IL1RN, LGALS3
45lactate448.2TLR4, LGALS3, IL1R1, IL1RN, CD14, MMP1
46retinoic acid44 249.1IL1RN, IL1R1, MMP1, CD14, LTF, STAT1
47ascorbic acid44 249.0TF, MPO, XDH, LTF, NOS2, MMP1
48cysteine448.0XDH, TLR2, STAT1, IL1R1, LTF, CD14
49nitric oxide44 11 249.4STAT1, TLR4, TLR3, TLR2, NOD2, TLR9
50vegf446.6TF, CD14, IL1RN, NOS2, LGALS3, IL10

GO Terms for genes affiliated with Pouchitis

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16Gene Ontology
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Cellular components related to Pouchitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome membraneGO:03602010.1TLR3, TLR9
2endosome membraneGO:0100089.3CD14, TF, TLR3, TLR9, TLR4
3cell surfaceGO:0099868.8TLR2, TLR3, CD14, EPO, IL1R1, NOD2
4extracellular regionGO:0055767.8TLR9, TF, XDH, LTF, CD14, EPO

Biological processes related to Pouchitis according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interferon-beta biosynthetic processGO:04535910.3TLR4, TLR3, TLR9
2positive regulation of interleukin-10 productionGO:03273310.3TLR4, NOD2, TLR9
3positive regulation of interleukin-18 productionGO:03274110.2TLR9, TLR2
4positive regulation of interferon-alpha biosynthetic processGO:04535610.2TLR3, TLR9
5cellular response to peptidoglycanGO:07122410.2TLR2, NOD2
6cellular response to lipoteichoic acidGO:07122310.1TLR4, CD14, TLR2
7positive regulation of JNK cascadeGO:04633010.1TLR4, TLR3, NOD2, TLR9
8I-kappaB kinase/NF-kappaB cascadeGO:00724910.1CD14, TLR3, TLR4
9response to exogenous dsRNAGO:04333010.1TLR3, NOD2, STAT1, IRAK3
10innate immune response in mucosaGO:00222710.0NOS2, NOD2
11TRIF-dependent toll-like receptor signaling pathwayGO:03566610.0TLR4, TLR3, CD14, NOD2
12positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.0TLR9, TLR2, NOD2, TLR4
13MyD88-independent toll-like receptor signaling pathwayGO:00275610.0CD14, TLR3, TLR4, NOD2
14toll-like receptor 3 signaling pathwayGO:03413810.0NOD2, TLR3, CD14, TLR4
15I-kappaB phosphorylationGO:00725210.0TLR9, TLR4, TLR2, TLR3
16positive regulation of chemokine productionGO:03272210.0TLR4, TLR3, TLR9, TLR2
17positive regulation of NF-kappaB import into nucleusGO:04234610.0TLR2, TLR3, TLR9, TLR4
18positive regulation of interferon-beta productionGO:03272810.0TLR4, TLR2, TLR9, TLR3
19lipopolysaccharide-mediated signaling pathwayGO:03166310.0TLR4, TLR2, STAT1
20positive regulation of toll-like receptor signaling pathwayGO:03412310.0TLR3, TLR9, TLR2, TLR5
21positive regulation of inflammatory responseGO:0507299.9TLR4, TLR2, TLR9, TLR3
22toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.9TLR2, NOD2, CD14, TLR4
23toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.9NOD2, CD14, TLR2, TLR4
24toll-like receptor 2 signaling pathwayGO:0341349.9TLR4, CD14, NOD2, TLR2
25negative regulation of interferon-gamma productionGO:0326899.9NOD2, TLR4, IL10
26cellular response to mechanical stimulusGO:0712609.9TLR3, TLR4, TLR5
27positive regulation of macrophage cytokine productionGO:0609079.9TLR4, TLR2
28positive regulation of interleukin-12 productionGO:0327359.8NOD2, TLR4, TLR2, TLR9, TLR3
29positive regulation of interleukin-6 productionGO:0327559.8NOD2, TLR2, TLR4, TLR9, TLR3
30negative regulation of tumor necrosis factor productionGO:0327209.8IRAK3, IL10, NOD2, TLR4
31negative regulation of interleukin-6 productionGO:0327159.8IL10, TLR9, TLR4, IRAK3
32response to interleukin-1GO:0705559.8IL1R1, EPO, IRAK3
33positive regulation of interleukin-8 productionGO:0327579.8TLR3, TLR4, TLR9, TLR5, TLR2
34positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.8TLR9, TLR3, LTF, NOD2, TLR4
35positive regulation of MHC class II biosynthetic processGO:0453489.8IL10, TLR4
36toll-like receptor 4 signaling pathwayGO:0341429.8TLR3, TLR4, TLR2, CD14, NOD2
37response to lipopolysaccharideGO:0324969.7NOD2, TLR4, IRAK3, EPO
38positive regulation of cytokine secretionGO:0507159.7CD14, TLR2, IL10
39negative regulation of interleukin-12 productionGO:0326959.7TLR2, IRAK3, IL10, NOD2
40positive regulation of tumor necrosis factor productionGO:0327609.7NOD2, TLR4, TLR2, TLR9, TLR3, CD14
41negative regulation of NF-kappaB transcription factor activityGO:0320889.6TLR9, NOD2, IRAK3
42negative regulation of growth of symbiont in hostGO:0441309.6TLR2, NOD2, IL10, MPO
43cellular response to lipopolysaccharideGO:0712229.5IL10, CD14, NOS2, TLR4
44MyD88-dependent toll-like receptor signaling pathwayGO:0027559.5TLR9, TLR5, TLR2, TLR4, IRAK3, CD14
45toll-like receptor signaling pathwayGO:0022249.4NOD2, TLR2, TLR5, TLR9, TLR3, CD14
46positive regulation of NF-kappaB transcription factor activityGO:0510929.3IRAK3, NOD2, LTF, TLR3, TLR4, TLR2
47innate immune responseGO:0450879.2TLR3, CD14, TLR2, NOD2, LGALS3, TLR9
48defense response to bacteriumGO:0427428.9TLR4, TLR9, TLR3, LTF, NOD2, NOS2
49positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TLR4, TLR2, TLR9, TLR3, STAT1, IL10
50inflammatory responseGO:0069548.8CD14, TLR3, TLR2, TLR9, TLR5, IL10

Molecular functions related to Pouchitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidoglycan bindingGO:04283410.0NOD2, TLR2
2interleukin-1 receptor bindingGO:0051499.8TLR5, TLR9, IL1RN
3lipoteichoic acid bindingGO:0708919.8CD14, TLR2
4lipopolysaccharide receptor activityGO:0018759.7TLR2, TLR4
5transmembrane signaling receptor activityGO:0048889.4IL1R1, TLR3, TLR9, TLR2, TLR4

Products for genes affiliated with Pouchitis

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  • Antibodies
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Sources for Pouchitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet