Aliases & Classifications for Pouchitis

MalaCards integrated aliases for Pouchitis:

Name: Pouchitis 55 51 69

Characteristics:

Orphanet epidemiological data:

55
pouchitis
Prevalence: 1-5/10000 (Europe);

Classifications:



External Ids:

Orphanet 55 ORPHA217067
MESH via Orphanet 42 D019449
UMLS via Orphanet 70 C0376620
UMLS 69 C0376620

Summaries for Pouchitis

MalaCards based summary : Pouchitis is related to ileitis and crohn's disease. An important gene associated with Pouchitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ciprofloxacin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and colon, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 72 Pouchitis is inflammation of the ileal pouch (an artificial rectum surgically created out of ileal gut... more...

Related Diseases for Pouchitis

Diseases related to Pouchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 ileitis 30.5 NOD2 TLR4
2 crohn's disease 29.9 IL10 NOD2 TLR4
3 colitis 29.8 CXCL8 IL10 NOD2 TLR4
4 ulcerative colitis 29.8 CXCL8 IL10 NOD2 TLR4
5 cytomegalovirus infection 29.8 CXCL8 IL10
6 pyoderma gangrenosum 29.8 CXCL8 NOD2
7 pyoderma 29.8 CXCL8 NOD2
8 prostatitis 29.2 CXCL8 IL10
9 arthritis 28.9 CXCL8 IL10 IL1RN NOD2
10 uveitis 28.9 IL10 NOD2
11 inflammatory bowel disease 28.0 CXCL8 IL10 IL1RN LTF NOD2 TLR4
12 hypersensitivity reaction type iv disease 10.3 IL1RN NOD2
13 inflammatory bowel disease 6 10.2 NOD2 TLR4
14 neisseria meningitidis infection 10.2 IL1RN TLR4
15 mucositis 10.2
16 spondyloarthropathy 1 10.2 IL1RN NOD2
17 familial mediterranean fever 10.2 IL1RN NOD2
18 acute graft versus host disease 10.1 IL10 NOD2
19 keratoconjunctivitis sicca 10.1 LTF TLR4
20 aphthous stomatitis 10.1 IL10 IL1RN
21 leprosy 3 10.1 IL10 NOD2
22 scrub typhus 10.1 IL10 TLR4
23 q fever 10.1 IL10 TLR4
24 familial adenomatous polyposis 10.1
25 paracoccidioidomycosis 10.1 IL10 TLR4
26 melioidosis 10.0 IL10 TLR4
27 sapho syndrome 10.0 CXCL8 NOD2
28 crohn's colitis 10.0 CXCL8 NOD2
29 filariasis 10.0 IL10 TLR4
30 necrotizing fasciitis 10.0 CXCL8 IL1RN
31 cholangitis 10.0
32 cholangitis, primary sclerosing 10.0
33 sclerosing cholangitis 10.0
34 cutaneous leishmaniasis 10.0 IL10 TLR4
35 bronchopulmonary dysplasia 10.0 CXCL8 IL1RN
36 felty syndrome 10.0 CXCL8 LTF
37 giant papillary conjunctivitis 10.0 CXCL8 LTF
38 primary bacterial infectious disease 10.0 IL10 TLR4
39 haemophilus influenzae 10.0 CXCL8 LTF
40 gastric ulcer 9.9 CXCL8 IL1RN
41 endometrial disease 9.9 CXCL8 TLR4
42 periodontosis 9.9 CXCL8 TLR4
43 bacteriuria 9.9 CXCL8 TLR4
44 septic arthritis 9.9 CXCL8 TLR4
45 middle ear disease 9.9 CXCL8 TLR4
46 perinatal necrotizing enterocolitis 9.9 CXCL8 TLR4
47 silicosis 9.9 CXCL8 IL1RN
48 invasive aspergillosis 9.9 CXCL8 TLR4
49 uterine anomalies 9.9 CXCL8 TLR4
50 aspergillosis 9.9 IL10 TLR4

Graphical network of the top 20 diseases related to Pouchitis:



Diseases related to Pouchitis

Symptoms & Phenotypes for Pouchitis

GenomeRNAi Phenotypes related to Pouchitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.36 NOD2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.36 IL10
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.36 IL10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-195 9.36 NOD2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.36 IL10
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 IL10
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.36 IL10
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.36 IL10 NOD2 TLR4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.36 NOD2

Drugs & Therapeutics for Pouchitis

Drugs for Pouchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
2 Vedolizumab Approved Phase 4 943609-66-3
3
Certolizumab pegol Approved Phase 4 428863-50-7
4 Antirheumatic Agents Phase 4,Phase 3
5 Gastrointestinal Agents Phase 4,Phase 3
6 Topoisomerase Inhibitors Phase 4
7 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
8 Cytochrome P-450 Enzyme Inhibitors Phase 4
9 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2
10 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
11 Immunosuppressive Agents Phase 4,Phase 3
12
Adalimumab Approved Phase 3 331731-18-1 16219006
13 Anti-Inflammatory Agents Phase 3
14
Alicaforsen Phase 3 185229-68-9 16197724
15 Antibiotics, Antitubercular Phase 3,Phase 1,Phase 2
16
Menthol Approved Phase 2 2216-51-5 16666
17
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
18 Antitubercular Agents Phase 2
19 Defensins
20 Scopolamine hydrobromide 114-49-8
21 Butylscopolammonium Bromide
22 Immunoglobulins
23 Antibodies
24 Acidophilus Nutraceutical

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 VSL#3 Treatment in Children With Crohn's Disease Unknown status NCT00367705 Phase 4
2 Phase 4 Study to Evaluate the Efficacy and Safety of Vedolizumab in the Treatment of Chronic Pouchitis Recruiting NCT02790138 Phase 4 Vedolizumab;Ciprofloxacin;Vedolizumab Placebo
3 EUS Evaluation of Perianal and Peri-rectal Fistulizing Crohn's Disease With CERTOLIZUMAB Treatment Terminated NCT01582568 Phase 4 Certolizumab
4 Adalimumab in the Treatment of Chronic Pouchitis Completed NCT01670240 Phase 3 Adalimumab;Placebo
5 Clinical Approaches to Ileal Pouch Dysfunction Completed NCT00293553 Phase 3
6 Efficacy of Alicaforsen in Pouchitis Patients Who Have Failed to Respond to at Least One Course of Antibiotics Recruiting NCT02525523 Phase 3 Alicaforsen;Placebo
7 To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis Completed NCT02201186 Phase 2
8 Safety and Efficacy of AST-120 in the Treatment of Pouchitis Completed NCT00583076 Phase 2 AST-120
9 Safety and Efficacy of Fecal Microbiome Transplantation (FMT) in the Treatment of Antibiotic Dependent Pouchitis (ADP) Recruiting NCT02782325 Phase 1, Phase 2
10 Fecal Microbiota Transplantation in the Treatment of Pouchitis Recruiting NCT03378921 Phase 2
11 FMT in Ulcerative Colitis-Associated Pouchitis Active, not recruiting NCT02049502 Phase 2
12 Clotrimazole Enemas for Pouchitis in Children and Adults Suspended NCT00061282 Phase 1, Phase 2 Clotrimazole
13 Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis Terminated NCT00583531 Phase 2 AST-120
14 Study of Sc-FOS for Pouchitis Prevention Active, not recruiting NCT02203955 Phase 1 Short-Chain Fructooligosaccharide;Maltodextrin
15 The Interaction Between Intestinal Microbiota, Innate Defense and Epithelial Integrity in the Development of Pouchitis Unknown status NCT01202396
16 Clinical Outcome After Close Rectal Ileo Pouch Anal Anastomosis for Colitis Ulcerosa(CU) Unknown status NCT01111708
17 Surgical Reconstruction in Ulcerative Colitis With Primary Sclerosing Cholangitis Completed NCT01798953
18 Characterization of Disease Related Changes in Inflammatory Bowel Disease Using Fecal Metabolite Profiling Completed NCT01666717
19 Microbiota and Immune microEnvironment in Pouchitis Recruiting NCT03136419
20 MRI in Normal Ileal Pouches, and a Feasibility Study of Dynamic MRI Enema and Defaecating MRI Pouchography Recruiting NCT02925260
21 Fecal Microbiota Transplant (FMT) for Pouchitis Active, not recruiting NCT02428361 Early Phase 1 Biologically active human fecal material, OpenBiome
22 Nutritional Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With IPAA Active, not recruiting NCT02828410
23 Corrona Inflammatory Bowel Disease (IBD) Registry Enrolling by invitation NCT03162549

Search NIH Clinical Center for Pouchitis

Genetic Tests for Pouchitis

Anatomical Context for Pouchitis

MalaCards organs/tissues related to Pouchitis:

38
Small Intestine, Liver, Colon, Endothelial, Neutrophil, T Cells, Testes

Publications for Pouchitis

Articles related to Pouchitis:

(show top 50) (show all 419)
# Title Authors Year
1
Vedolizumab in the treatment of chronic, antibiotic-dependent or refractory pouchitis. ( 29266360 )
2018
2
Effective use of ustekinumab for prepouch ileitis without improvement of concomitant pouchitis. ( 29423578 )
2018
3
Editorial: biologic therapy for chronic pouchitis - are we beginning to meet the unmet need? ( 29446134 )
2018
4
Systematic Review With Meta-Analysis: Anti-TNF Therapy in Refractory Pouchitis and Crohn's Disease-Like Complications of the Pouch After Ileal Pouch-Anal Anastomosis Following Colectomy for Ulcerative Colitis. ( 29361101 )
2018
5
NOD2 genetic variants predispose one of two familial adenomatous polyposis siblings to pouchitis through microbiome dysbiosis. ( 28633443 )
2017
6
Frequency and Risk Factors of Clostridium difficile Infection in Hospitalized Patients With Pouchitis: A Population-based Study. ( 28296825 )
2017
7
Refractory pouchitis improves after administration of the green tea polyphenol EGCG: a retrospective review. ( 28929216 )
2017
8
Successful Treatment With Vedolizumab in a Patient With Chronic Refractory Pouchitis and Primary Sclerosing Cholangitis. ( 29106505 )
2017
9
Preoperative Extraintestinal Manifestations Associated with Chronic Pouchitis in Japanese Patients with Ulcerative Colitis After Ileal Pouch-anal Anastomosis: A Retrospective Study. ( 28346273 )
2017
10
Tripterygium wilfordii polyglycosidium ameliorates pouchitis induced by dextran sulfate sodium in rats. ( 27988458 )
2017
11
Efficacy of Vedolizumab in Patients with Antibiotic and Anti-tumor Necrosis Alpha Refractory Pouchitis. ( 27930413 )
2017
12
Cryptosporidium Pouchitis. ( 28223201 )
2017
13
Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. ( 28221248 )
2017
14
Successful Treatment With Ustekinumab for Chronic Refractory Pouchitis. ( 28199485 )
2017
15
Pouchitis after ileal pouch-anal anastomosis in ulcerative colitis: Diagnosis, management, risk factors, and incidence. ( 27681447 )
2017
16
Predictors of pouchitis after ileal pouch-anal anastomosis in pediatric-onset ulcerative colitis. ( 28542114 )
2017
17
Successful treatment of pouchitis with Vedolizumab, but not fecal microbiota transfer (FMT), after proctocolectomy in ulcerative colitis. ( 28097380 )
2017
18
Intestinal Barrier Disruption in Ileal Pouchitis After Ileal Pouch-Anal Anastomosis in a Rat Model. ( 28486255 )
2017
19
Lactobacillus acidophilus alleviates pouchitis after ileal pouch-anal anastomosis in rats. ( 28765694 )
2017
20
Central Serous Chorioretinopathy in a Patient with Ulcerative Colitis with Pouchitis on Budesonide-EC. ( 28328626 )
2017
21
Combination therapy with vedolizumab and etanercept in a patient with pouchitis and spondylarthritis. ( 28243458 )
2017
22
Altered expression of microRNAs in patients with pouchitis after restorative proctocolectomy. ( 28600635 )
2017
23
Endoscopic Treatment of Bleeding Diversion Pouchitis with High-Concentration Dextrose Spray. ( 28377939 )
2017
24
Colonic Histological Criteria Predict Development of Pouchitis after Ileal Pouch: Anal Anastomosis for Patients with Ulcerative Colitis. ( 28662525 )
2017
25
Efficacy of granulocyte and monocyte apheresis for antibiotic-refractory pouchitis after proctocolectomy for ulcerative colitis: an open-label, prospective, multicentre study. ( 28203278 )
2017
26
Abdominal Visceral Fat Area and Chronic Pouchitis after Ileal Pouch-Anal Anastomosis. ( 29391089 )
2017
27
Successful treatment of chronic refractory pouchitis with vedolizumab. ( 28698974 )
2017
28
Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. ( 28248733 )
2017
29
Alicaforsen in the treatment of pouchitis. ( 29067882 )
2017
30
Sulfasalazine in Prevention of Pouchitis After Proctocolectomy with Ileal Pouch-Anal Anastomosis for Ulcerative Colitis. ( 28110377 )
2017
31
Short article: Successful faecal coliform sensitivity-based oral ertapenem therapy for chronic antibiotic-refractory pouchitis: a case series. ( 26657456 )
2016
32
Pouchitis Associated With Pelvic Radiation for Prostate Cancer. ( 27807581 )
2016
33
Predictors of Pouchitis After Ileal Pouch-Anal Anastomosis in Children. ( 27243421 )
2016
34
Fecal Microbiota Transfer in Patients With Chronic Antibiotic-Refractory Pouchitis. ( 27018122 )
2016
35
The current place of probiotics and prebiotics in the treatment of pouchitis. ( 27048898 )
2016
36
The prevalence of chronic peri-pouch sepsis in patients treated for antibiotic-dependent or refractory primary idiopathic pouchitis. ( 27688067 )
2016
37
Role of intestinal flora imbalance in pathogenesis of pouchitis. ( 27569889 )
2016
38
Secondary pouchitis in a pediatric patient successfully treated by salvage surgery. ( 27097567 )
2016
39
Reply to a Letter to the Editor Regarding the Original Article, Predictors of Pouchitis After Ileal Pouch-Anal Anastomosis in Children. ( 27574882 )
2016
40
Fecal microbiota in pouchitis and ulcerative colitis. ( 27833384 )
2016
41
Pouchitis Is a Common Complication in Patients With FamilialA Adenomatous Polyposis Following Ileal Pouch-Anal Anastomosis. ( 27085760 )
2016
42
Campylobacter Pouchitis Mimicking the Appearance of Crohn's Disease. ( 27555972 )
2016
43
Immunoglobulin G4 (IgG4)-associated pouchitis - Part of IgG4 related disease? A case series and review of the literature. ( 27038705 )
2016
44
Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm. ( 28008631 )
2016
45
Endoluminal calprotectin measurement in assessment of pouchitis and a new index of disease activity: a pilot study. ( 26901424 )
2016
46
Alicaforsen, an antisense inhibitor of ICAM-1, as treatment for chronic refractory pouchitis after proctocolectomy: A case series. ( 26966529 )
2016
47
Review article: the pathogenesis of pouchitis. ( 27554912 )
2016
48
Patient-Specific Bacteroides Genome Variants in Pouchitis. ( 27935837 )
2016
49
Pouchitis in Pediatric Ulcerative Colitis Patients After Ileal Pouch Anal Anastomosis. ( 27602702 )
2016
50
Methodological Quality Assessment of Meta-Analyses and Systematic Reviews of Probiotics in Inflammatory Bowel Disease and Pouchitis. ( 28005973 )
2016

Variations for Pouchitis

Expression for Pouchitis

Search GEO for disease gene expression data for Pouchitis.

Pathways for Pouchitis

Pathways related to Pouchitis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 CXCL8 IL10 IL1RN LTF NOD2 TLR4
2
Show member pathways
12.96 CXCL8 IL10 IL1RN NOD2
3
Show member pathways
12.53 CXCL8 IL1RN NOD2 TLR4
4
Show member pathways
12.21 IL10 NOD2 TLR4
5
Show member pathways
12.14 CXCL8 IL10 TLR4
6 11.8 IL10 NOD2 TLR4
7 11.71 CXCL8 IL10 IL1RN
8 11.42 CXCL8 IL10 TLR4
9 11.36 IL10 TLR4
10 11.34 CXCL8 NOD2
11 11.25 CXCL8 TLR4
12 11.21 CXCL8 IL10 TLR4
13 11 IL10 TLR4
14 10.82 CXCL8 IL10 IL1RN
15 10.49 CXCL8 IL10 TLR4

GO Terms for Pouchitis

Biological processes related to Pouchitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.81 LTF NOD2 TLR4
2 regulation of receptor activity GO:0010469 9.79 CXCL8 IL10 IL1RN
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.69 LTF NOD2 TLR4
4 defense response to Gram-negative bacterium GO:0050829 9.63 LTF TLR4
5 regulation of inflammatory response GO:0050727 9.62 NOD2 TLR4
6 positive regulation of JNK cascade GO:0046330 9.62 NOD2 TLR4
7 immune response GO:0006955 9.62 CXCL8 IL10 IL1RN TLR4
8 response to glucocorticoid GO:0051384 9.61 IL10 IL1RN
9 positive regulation of tumor necrosis factor production GO:0032760 9.6 NOD2 TLR4
10 positive regulation of interleukin-6 production GO:0032755 9.59 NOD2 TLR4
11 negative regulation of tumor necrosis factor production GO:0032720 9.58 IL10 TLR4
12 positive regulation of interleukin-8 production GO:0032757 9.58 NOD2 TLR4
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.58 LTF NOD2 TLR4
14 negative regulation of interferon-gamma production GO:0032689 9.57 IL10 TLR4
15 negative regulation of interleukin-6 production GO:0032715 9.56 IL10 TLR4
16 positive regulation of interleukin-1 beta secretion GO:0050718 9.55 NOD2 TLR4
17 positive regulation of interleukin-10 production GO:0032733 9.54 NOD2 TLR4
18 cellular response to lipopolysaccharide GO:0071222 9.54 CXCL8 IL10 TLR4
19 positive regulation of stress-activated MAPK cascade GO:0032874 9.52 NOD2 TLR4
20 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.49 NOD2 TLR4
21 positive regulation of macrophage activation GO:0043032 9.48 IL10 TLR4
22 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.46 NOD2 TLR4
23 response to molecule of bacterial origin GO:0002237 9.43 CXCL8 IL10
24 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.26 IL10 IL1RN
25 inflammatory response GO:0006954 9.26 CXCL8 IL10 IL1RN TLR4
26 positive regulation of MHC class II biosynthetic process GO:0045348 9.16 IL10 TLR4
27 defense response to bacterium GO:0042742 8.92 IL10 LTF NOD2 TLR4

Molecular functions related to Pouchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.96 LTF TLR4
2 cytokine activity GO:0005125 8.8 CXCL8 IL10 IL1RN

Sources for Pouchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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