MCID: PRB001
MIFTS: 36

Pre-B-Cell Acute Lymphoblastic Leukemia malady

Immune category

Summaries for Pre-B-Cell Acute Lymphoblastic Leukemia

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33MalaCards
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MalaCards: Pre-B-Cell Acute Lymphoblastic Leukemia, also known as pre b-cell acute lymphoblastic leukemia, is related to acute leukemia and t-cell leukemia. An important gene associated with Pre-B-Cell Acute Lymphoblastic Leukemia is BRCA2 (breast cancer 2, early onset), and among its related pathways are Interleukin-7 signaling and Signaling by Interleukins. The compounds platinum compounds and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, t cells and b lymphoblasts, and related mouse phenotypes are nervous system and embryogenesis.

Aliases & Classifications for Pre-B-Cell Acute Lymphoblastic Leukemia

Sources:
47OMIM, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

pre-b-cell acute lymphoblastic leukemia 47
pre b-cell acute lymphoblastic leukemia 61


Related Diseases for Pre-B-Cell Acute Lymphoblastic Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pre-B-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.6THY1, PBX1, KMT2A, IL7, ETV6, MYB
2t-cell leukemia31.3MYB, ZAP70, TCL1A
3acute lymphoblastic leukemia, childhood31.0KMT2A, XRCC1, IL7, ETV6, NR3C1
4acute t cell leukemia10.9
5adult t-cell leukemia10.4
6aleukemic leukemia cutis10.4
7lymphoblastic lymphoma10.4
8pediatric t-cell leukemia10.4
9rosai-dorfman disease10.4
10viral hepatitis10.0MYB
11multiple sclerosis10.0IL7R, IL7
12hepatitis b10.0MYB, ERCC2
13lymphoma aidsrelated10.0IL7, TCL1A
14lung cancer10.0ERCC2, XRCC1
15prolymphocytic leukemia10.0ZAP70, TCL1A
16skin cancer10.0XRCC1, ERCC2
17gamma chain deficiency10.0IL2RG, IL7R, IL7
18myelodysplastic syndromes10.0KMT2A, ETV6
19retinoblastoma10.0MYB, BRCA2
20fibrosarcoma10.0MYB, THY1, ETV6
21cutaneous t cell lymphoma10.0MYB, IL7R, IL7
22peripheral t-cell lymphoma10.0TCL1A, ETV6, ZAP70
23ovarian cancer10.0BRCA2, ERCC2
24acute myelomonocytic leukemia10.0KMT2A, ETV6
25myeloid leukemia10.0ETV6, MYB, KMT2A
26lymphopenia10.0ZAP70, IL7R, IL7, IL2RG
27burkitt's lymphoma10.0MYB, IL7, TCL1A, ZAP70
28severe combined immunodeficiency10.0ZAP70, IL7, IL2RG, IL7R
29sarcoma10.0ETV6, THY1, BRCA2
30thymoma10.0THY1, IL7
31follicular lymphoma10.0MYB, KMT2A, TCL1A, ZAP70
32b-cell lymphomas10.0TCL1A, KMT2A, ZAP70
33obesity10.0NR3C1, PBX1, XRCC1
34precursor b-cell acute lymphoblastic leukemia10.0ETV6, IL7, KMT2A, PBX1
35colorectal cancer10.0MYB, XRCC1, BRCA2, ERCC2
36ipex syndrome10.0ZAP70, IL7R, IL7, MYB, IL2RG
37myeloma10.0IL7, IL7R, NR3C1, TCL1A
38stomach cancer10.0BRCA2, NR3C1, XRCC1
39cervical cancer10.0XRCC1, NR3C1, IL7
40rheumatoid arthritis10.0IL7, MYB, NR3C1, ZAP70
41b-cell chronic lymphocytic leukemia10.0TCL1A, IL7, ZAP70, KMT2A, BRCA2
42hodgkin's lymphoma10.0TCL1A, KMT2A, IL7, ZAP70, BRCA2
43viral infectious disease10.0ZAP70, MYB, IL7R, IL7, NR3C1
44non-small cell lung carcinoma10.0NR3C1, XRCC1, ERCC2, IL7
45chronic lymphocytic leukemia10.0BRCA2, ZAP70, MYB, IL7, KMT2A, TCL1A
46hematologic cancer10.0KMT2A, NR3C1, ETV6, ZAP70, IL7
47non-hodgkin lymphoma10.0KMT2A, IL7, MYB, ERCC2, ETV6, THY1
48adenocarcinoma9.9BRCA2, KMT2A, ERCC2, XRCC1, NR3C1, MYB
49melanoma9.9ZAP70, MYB, IL7, XRCC1, IL7R, BRCA2
50prostate cancer9.9ERCC2, NR3C1, IL7, KMT2A, XRCC1, PBX1

Graphical network of the top 20 diseases related to Pre-B-Cell Acute Lymphoblastic Leukemia:



Diseases related to pre-b-cell acute lymphoblastic leukemia

Clinical Features for Pre-B-Cell Acute Lymphoblastic Leukemia

Drugs & Therapeutics for Pre-B-Cell Acute Lymphoblastic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pre-B-Cell Acute Lymphoblastic Leukemia

Drug clinical trials:

Search ClinicalTrials for Pre-B-Cell Acute Lymphoblastic Leukemia

Search NIH Clinical Center for Pre-B-Cell Acute Lymphoblastic Leukemia

Search CenterWatch for Pre-B-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Pre-B-Cell Acute Lymphoblastic Leukemia

Anatomical Context for Pre-B-Cell Acute Lymphoblastic Leukemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Pre-B-Cell Acute Lymphoblastic Leukemia:

33
Bone marrow, T cells, B lymphoblasts, B cells

Animal Models for Pre-B-Cell Acute Lymphoblastic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Pre-B-Cell Acute Lymphoblastic Leukemia

Sources:
51PubMed
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Articles related to Pre-B-Cell Acute Lymphoblastic Leukemia:

(show all 25)
idTitleAuthorsYear
1
Frequencies of immature CD34 + CD38 - and CD34 + CD38-CD19 + blasts correlate with minimal residual disease level in pediatric B-cell precursor acute lymphoblastic leukemia. (23432723)
2013
2
Incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philadelphia chromosome positive B-cell precursor acute lymphoblastic leukemia. (24323986)
2013
3
Impact of IKZF1 deletions on IKZF1 expression and outcome in Philadelphia chromosome negative childhood BCP-ALL. Reply to "Incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philadelphia chromosome positive B-cell precursor acute lymphoblastic leukemia". (24323991)
2013
4
Impact of mutations in FLT3, PTPN11, and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil. (24067137)
2013
5
Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia. (22699455)
2013
6
Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011. (23823658)
2013
7
Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report. (23057758)
2012
8
Prediction of outcome by early bone marrow response in childhood acute lymphoblastic leukemia treated in the ALL-BFM 95 trial: differential effects in precursor B-cell and T-cell leukemia. (22271901)
2012
9
LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome. (21459790)
2011
10
Gene-based outcome prediction in multiple cohorts of pediatric T-cell acute lymphoblastic leukemia: a Children's Oncology Group study. (20459861)
2010
11
Differential effects of BAFF on B cell precursor acute lymphoblastic leukemia and Burkitt lymphoma. (20428981)
2010
12
MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia. (20544842)
2010
13
GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. (19922767)
2010
14
High expression of CD40 on B-cell precursor acute lymphoblastic leukemia blasts is an independent risk factor associated with improved survival and enhanced capacity to up-regulate the death receptor CD95. (18552209)
2008
15
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
16
Identification of immunoglobulin and T-cell receptor gene rearrangements--prerequisite for monitoring of minimal residual disease in Polish acute lymphoblastic leukemia patients based on European standards. Preliminary results]. (17028396)
2006
17
Engraftment of human T-cell acute lymphoblastic leukemia in immunodeficient NOD/SCID mice which have been preconditioned by injection of human cord blood. (11553853)
2001
18
Regeneration pattern of precursor-B-cells in bone marrow of acute lymphoblastic leukemia patients depends on the type of preceding chemotherapy. (10764156)
2000
19
Detection of clonotypic IGH and TCR rearrangements in the neonatal blood spots of infants and children with B-cell precursor acute lymphoblastic leukemia. (10891460)
2000
20
Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor alpha beta lineage. (10361104)
1999
21
Expression of CD10, CD19 and CD34 markers in bone marrow samples of children with precursor B-cell acute lymphoblastic leukemia in clinical and hematological remission. (9890666)
1998
22
Expansion of polyclonal B-cell precursors in bone marrow from children treated for acute lymphoblastic leukemia. (9262991)
1997
23
Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain. (8709637)
1996
24
Long-term survival and proliferation of precursor-B acute lymphoblastic leukemia cells on human bone marrow stroma. (8656676)
1996
25
Methylation status of T-cell receptor beta-chain gene in B precursor acute lymphoblastic leukemia: correlation with hypomethylation and gene rearrangement. (1851666)
1991

Genetic Variations for Pre-B-Cell Acute Lymphoblastic Leukemia

Expression for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for Pre-B-Cell Acute Lymphoblastic Leukemia.

Pathways for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

Sources:
54Reactome, 53R&D Systems, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL7, IL2RG
2
Hide members
9.8IL2RG, IL7
39.6ZAP70, IL7R, IL2RG
4
Hide members
9.6BRCA2, ERCC2, XRCC1
5
Hide members
9.6BRCA2, XRCC1, ERCC2
6
Hide members
9.6IL7R, IL7, IL2RG
79.6IL7, IL2RG, IL7R
8
Hide members
9.6IL2RG, IL7, IL7R
99.3MYB, IL2RG, THY1
109.1NR3C1, TCF3, MYB, PBX1
11
Hide members
8.9IL7, IL7, IL7R, ZAP70, IL2RG
128.8IL7R, IL7, IL2RG, TCL1A, MYB
138.6ZAP70, MYB, PBX1, TCF3, THY1
148.4KMT2A, PBX1, ETV6, TCF3

Compounds for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

Sources:
50PharmGKB, 45Novoseek, 24HMDB, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1platinum compounds5010.1ERCC2, XRCC1
28-oxoguanine4510.1XRCC1, BRCA2
3estrogen4510.0KMT2A
4mspi459.9XRCC1, ERCC2, BRCA2
5cotinine45 2410.9XRCC1, ERCC2
6fluorouracil50 1110.8XRCC1, ERCC2
7imatinib45 50 1111.5ETV6, MYB, ZAP70
8cyclophosphamide45 50 1111.5XRCC1, ZAP70, IL7, ERCC2
9hydrocortisone45 2 60 1112.5PBX1, IL7, NR3C1
10folate459.5BRCA2, XRCC1, ERCC2
11steroid459.5BRCA2, MYB, IL7, PBX1
12glutamine459.4BRCA2, MYB, NR3C1, XRCC1
13thymidine45 2410.4BRCA2, MYB, IL7, ZAP70
14vincristine45 50 1111.4BRCA2, KMT2A, ERCC2
15cisplatin45 50 60 1112.4BRCA2, ERCC2, NR3C1, XRCC1
16estradiol45 11 2411.1IL7, PBX1, MYB, NR3C1, BRCA2
17progesterone45 60 29 11 2413.1BRCA2, NR3C1, MYB, IL7, PBX1
18etoposide45 50 60 1112.0NR3C1, BRCA2, XRCC1, KMT2A
19prednisolone45 29 1111.0ETV6, KMT2A, NR3C1
20genistein45 29 60 2 11 2414.0IL7, ZAP70, BRCA2, KMT2A
21dexamethasone45 50 29 1112.0ZAP70, PBX1, NR3C1, MYB, IL7
22doxorubicin45 50 1110.9KMT2A, IL7, MYB, NR3C1
23vegf458.9IL7, NR3C1, MYB, ERCC2, ETV6
24serine458.8KMT2A, TCL1A
25zinc45 249.6KMT2A, PBX1, MYB, BRCA2, XRCC1
26leucine458.6KMT2A, ZAP70, MYB, PBX1
27oligonucleotide458.5KMT2A, IL7, MYB, ZAP70, XRCC1, BRCA2
28retinoic acid45 249.2IL7, ETV6, MYB, NR3C1, KMT2A, BRCA2
29tyrosine456.6PBX1, IL2RG, MYB, THY1, ETV6, IL7

GO Terms for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3THY1, IL2RG, IL7R
2nucleoplasmGO:0056548.6ERCC2, TCF3, NR3C1, XRCC1, BRCA2

Biological processes related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1interleukin-7-mediated signaling pathwayGO:03811110.1IL2RG, IL7R
2homeostasis of number of cellsGO:04887210.0IL7R, MYB
3T cell differentiationGO:0302179.9IL7R, ZAP70
4positive regulation of T cell differentiationGO:0455829.9ZAP70, IL7
5histone H4 acetylationGO:0439679.7TCF3, BRCA2
6adrenal gland developmentGO:0303259.5PBX1, NR3C1
7embryonic hemopoiesisGO:0351629.2PBX1, KMT2A
8positive regulation of transcription, DNA-dependentGO:0458938.7BRCA2, MYB, KMT2A, TCF3, ERCC2

Molecular functions related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-7 receptor activityGO:0049179.8IL7R, IL2RG
2sequence-specific DNA bindingGO:0435658.8TCF3, PBX1, ETV6, NR3C1
3sequence-specific DNA binding transcription factor activityGO:0037007.5TCF3, PBX1, KMT2A, ETV6, MYB, NR3C1
4protein bindingGO:0055154.5KMT2A, IL7, IL2RG, ETV6, PBX1, THY1

Products for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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  • Antibodies

Sources for Pre-B-Cell Acute Lymphoblastic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet