MCID: PRB001
MIFTS: 33

Pre-B-Cell Acute Lymphoblastic Leukemia malady

Immune diseases category

Summaries for Pre-B-Cell Acute Lymphoblastic Leukemia

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32MalaCards
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MalaCards: Pre-B-Cell Acute Lymphoblastic Leukemia, also known as pre b-cell acute lymphoblastic leukemia, is related to acute leukemia and leukemia. An important gene associated with Pre-B-Cell Acute Lymphoblastic Leukemia is BRCA2 (breast cancer 2, early onset), and among its related pathways are Interleukin-7 signaling and Signaling by Interleukins. The compounds platinum compounds and 8-oxoguanine have been mentioned in the context of this disorder. Affiliated tissues include b cells, and related mouse phenotypes are nervous system and embryogenesis.

Aliases & Classifications for Pre-B-Cell Acute Lymphoblastic Leukemia

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46OMIM, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

pre-b-cell acute lymphoblastic leukemia 46
pre b-cell acute lymphoblastic leukemia 60


Related Diseases for Pre-B-Cell Acute Lymphoblastic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Pre-B-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.6MYB, ETV6, IL7, KMT2A, PBX1, THY1
2leukemia31.5ETV6, MYB, NR3C1, ZAP70, XRCC1, BRCA2
3t-cell leukemia30.7TCL1A, MYB, ZAP70
4sarcoma30.7THY1, ETV6, BRCA2
5severe combined immunodeficiency30.5ZAP70, IL7R, IL7, IL2RG
6lymphoblastic leukemia11.1
7acute t cell leukemia10.7
8childhood leukemia10.7
9aleukemic leukemia cutis10.4
10chromosomal disease10.4
11viral hepatitis10.0MYB
12multiple sclerosis10.0IL7, IL7R
13hepatitis b10.0ERCC2, MYB
14lymphoma aidsrelated10.0IL7, TCL1A
15lung cancer10.0ERCC2, XRCC1
16prolymphocytic leukemia10.0TCL1A, ZAP70
17gamma chain deficiency10.0IL7R, IL7, IL2RG
18myelodysplastic syndromes10.0KMT2A, ETV6
19retinoblastoma10.0BRCA2, MYB
20fibrosarcoma10.0THY1, ETV6, MYB
21cutaneous t cell lymphoma10.0MYB, IL7R, IL7
22peripheral t-cell lymphoma10.0ZAP70, ETV6, TCL1A
23ovarian cancer10.0BRCA2, ERCC2
24acute myelomonocytic leukemia10.0KMT2A, ETV6
25myeloid leukemia10.0MYB, ETV6, KMT2A
26lymphopenia10.0ZAP70, IL7R, IL7, IL2RG
27burkitt's lymphoma10.0TCL1A, IL7, MYB, ZAP70
28thymoma10.0IL7, THY1
29follicular lymphoma10.0ZAP70, MYB, KMT2A, TCL1A
30b-cell lymphomas10.0TCL1A, KMT2A, ZAP70
31obesity10.0PBX1, NR3C1, XRCC1
32precursor b-cell acute lymphoblastic leukemia10.0PBX1, KMT2A, IL7, ETV6
33colorectal cancer10.0BRCA2, XRCC1, MYB, ERCC2
34ipex syndrome10.0ZAP70, MYB, IL7R, IL7, IL2RG
35myeloma10.0NR3C1, IL7R, IL7, TCL1A
36stomach cancer10.0NR3C1, XRCC1, BRCA2
37cervical cancer10.0XRCC1, NR3C1, IL7
38rheumatoid arthritis10.0ZAP70, NR3C1, MYB, IL7
39b-cell chronic lymphocytic leukemia10.0BRCA2, ZAP70, IL7, KMT2A, TCL1A
40hodgkin's lymphoma10.0BRCA2, ZAP70, IL7, KMT2A, TCL1A
41viral infectious disease10.0ZAP70, NR3C1, MYB, IL7R, IL7
42non-small cell lung carcinoma10.0ERCC2, IL7, NR3C1, XRCC1
43chronic lymphocytic leukemia10.0BRCA2, ZAP70, MYB, IL7, KMT2A, TCL1A
44hematologic cancer10.0KMT2A, IL7, ETV6, NR3C1, ZAP70
45non-hodgkin lymphoma10.0MYB, ETV6, IL7, KMT2A, THY1, TCL1A
46acute lymphoblastic leukemia, childhood10.0XRCC1, NR3C1, ETV6, IL7, KMT2A
47adenocarcinoma10.0ERCC2, KMT2A, MYB, NR3C1, XRCC1, BRCA2
48melanoma9.9BRCA2, XRCC1, ZAP70, MYB, IL7R, IL7
49prostate cancer9.9BRCA2, XRCC1, NR3C1, IL7, KMT2A, PBX1
50precursor t-cell acute lymphoblastic leukemia9.9ZAP70, NR3C1, MYB, ETV6, IL7R, IL7

Graphical network of the top 20 diseases related to Pre-B-Cell Acute Lymphoblastic Leukemia:



Diseases related to pre-b-cell acute lymphoblastic leukemia

Clinical Features for Pre-B-Cell Acute Lymphoblastic Leukemia

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Drugs & Therapeutics for Pre-B-Cell Acute Lymphoblastic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Pre-B-Cell Acute Lymphoblastic Leukemia

Drug clinical trials:

Search ClinicalTrials for Pre-B-Cell Acute Lymphoblastic Leukemia

Search NIH Clinical Center for Pre-B-Cell Acute Lymphoblastic Leukemia

Search CenterWatch for Pre-B-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Pre-B-Cell Acute Lymphoblastic Leukemia

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Anatomical Context for Pre-B-Cell Acute Lymphoblastic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Pre-B-Cell Acute Lymphoblastic Leukemia:

32
B cells

Animal Models for Pre-B-Cell Acute Lymphoblastic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Pre-B-Cell Acute Lymphoblastic Leukemia:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.4TCF3, KMT2A
2MP:00053809.3TCF3, KMT2A, IL2RG
3MP:00020068.8ETV6, IL2RG, KMT2A, TCF3
4MP:00053908.4BRCA2, NR3C1, IL2RG, KMT2A, PBX1
5MP:00030127.7NR3C1, MYB, ETV6, IL7, KMT2A, TCF3
6MP:00053897.7BRCA2, NR3C1, IL2RG, KMT2A, PBX1, TCL1A
7MP:00107717.1BRCA2, ZAP70, NR3C1, MYB, ETV6, KMT2A
8MP:00028737.0BRCA2, XRCC1, ZAP70, NR3C1, MYB, ETV6
9MP:00053786.9BRCA2, XRCC1, NR3C1, MYB, ETV6, KMT2A
10MP:00107686.7BRCA2, XRCC1, NR3C1, MYB, ETV6, IL2RG
11MP:00053766.6BRCA2, XRCC1, NR3C1, ETV6, IL2RG, KMT2A
12MP:00053976.3ERCC2, BRCA2, ZAP70, NR3C1, MYB, ETV6
13MP:00053876.2ETV6, MYB, NR3C1, ZAP70, BRCA2, IL7R
14MP:00053845.9MYB, NR3C1, ZAP70, XRCC1, BRCA2, ETV6

Publications for Pre-B-Cell Acute Lymphoblastic Leukemia

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Genetic Variations for Pre-B-Cell Acute Lymphoblastic Leukemia

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Expression for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for Pre-B-Cell Acute Lymphoblastic Leukemia.

Pathways for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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53Reactome, 52R&D Systems, 29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL7, IL2RG
2
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9.8IL2RG, IL7
39.6ZAP70, IL7R, IL2RG
4
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9.6BRCA2, ERCC2, XRCC1
5
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9.6BRCA2, XRCC1, ERCC2
6
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9.6IL7R, IL7, IL2RG
79.6IL7, IL2RG, IL7R
8
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9.6IL2RG, IL7, IL7R
99.3MYB, IL2RG, THY1
109.1NR3C1, TCF3, MYB, PBX1
11
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8.9IL7, IL7, IL7R, ZAP70, IL2RG
128.8IL7R, IL7, IL2RG, TCL1A, MYB
138.6ZAP70, MYB, PBX1, TCF3, THY1
148.4KMT2A, PBX1, ETV6, TCF3

Compounds for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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49PharmGKB, 44Novoseek, 24HMDB, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1platinum compounds4910.1ERCC2, XRCC1
28-oxoguanine4410.1BRCA2, XRCC1
3estrogen4410.0KMT2A
4mspi449.9ERCC2, XRCC1, BRCA2
5cotinine44 2410.9ERCC2, XRCC1
6fluorouracil49 1110.8ERCC2, XRCC1
7imatinib44 49 1111.5ETV6, MYB, ZAP70
8cyclophosphamide44 49 1111.5ERCC2, IL7, ZAP70, XRCC1
9hydrocortisone44 2 59 1112.5NR3C1, IL7, PBX1
10folate449.5ERCC2, XRCC1, BRCA2
11steroid449.5BRCA2, MYB, IL7, PBX1
12glutamine449.4BRCA2, XRCC1, NR3C1, MYB
13thymidine44 2410.4BRCA2, ZAP70, MYB, IL7
14vincristine44 49 1111.4ERCC2, KMT2A, BRCA2
15cisplatin44 49 59 1112.4ERCC2, NR3C1, XRCC1, BRCA2
16estradiol44 11 2411.1BRCA2, NR3C1, MYB, IL7, PBX1
17progesterone44 59 28 11 2413.1BRCA2, NR3C1, MYB, IL7, PBX1
18etoposide44 49 59 1112.0BRCA2, XRCC1, NR3C1, KMT2A
19prednisolone44 28 1111.0KMT2A, ETV6, NR3C1
20genistein44 28 59 2 11 2414.0KMT2A, IL7, ZAP70, BRCA2
21dexamethasone44 49 28 1112.0PBX1, IL7, MYB, NR3C1, ZAP70
22doxorubicin44 49 1110.9NR3C1, MYB, IL7, KMT2A
23vegf448.9NR3C1, MYB, ETV6, IL7, ERCC2
24serine448.8TCL1A, KMT2A
25zinc44 249.6BRCA2, XRCC1, MYB, KMT2A, PBX1
26leucine448.6ZAP70, MYB, KMT2A, PBX1
27oligonucleotide448.5BRCA2, XRCC1, ZAP70, MYB, IL7, KMT2A
28retinoic acid44 249.2KMT2A, IL7, ETV6, MYB, NR3C1, BRCA2
29tyrosine446.6THY1, XRCC1, ZAP70, MYB, ETV6, IL7R

GO Terms for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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16Gene Ontology
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Cellular components related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3THY1, IL2RG, IL7R
2nucleoplasmGO:0056548.6ERCC2, TCF3, NR3C1, XRCC1, BRCA2

Biological processes related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1interleukin-7-mediated signaling pathwayGO:03811110.1IL2RG, IL7R
2homeostasis of number of cellsGO:04887210.0IL7R, MYB
3histone H4 acetylationGO:0439679.9BRCA2, TCF3
4T cell differentiationGO:0302179.9ZAP70, IL7R
5positive regulation of T cell differentiationGO:0455829.9IL7, ZAP70
6adrenal gland developmentGO:0303259.3NR3C1, PBX1
7embryonic hemopoiesisGO:0351629.2KMT2A, PBX1
8positive regulation of transcription, DNA-dependentGO:0458938.7TCF3, KMT2A, ERCC2, MYB, BRCA2

Molecular functions related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-7 receptor activityGO:0049179.8IL7R, IL2RG
2sequence-specific DNA bindingGO:0435658.8TCF3, PBX1, ETV6, NR3C1
3sequence-specific DNA binding transcription factor activityGO:0037007.5TCF3, PBX1, KMT2A, ETV6, MYB, NR3C1
4protein bindingGO:0055154.5KMT2A, IL7, IL2RG, ETV6, PBX1, THY1

Products for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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Sources for Pre-B-Cell Acute Lymphoblastic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet