MCID: PRB001
MIFTS: 40

Pre-B-Cell Acute Lymphoblastic Leukemia malady

Immune diseases category
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Summaries for Pre-B-Cell Acute Lymphoblastic Leukemia

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33MalaCards
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MalaCards: Pre-B-Cell Acute Lymphoblastic Leukemia, also known as pre b-cell acute lymphoblastic leukemia, is related to leukemia and severe combined immunodeficiency. An important gene associated with Pre-B-Cell Acute Lymphoblastic Leukemia is BRCA2 (breast cancer 2, early onset), and among its related pathways are Primary immunodeficiency and Regulation of nuclear SMAD2/3 signaling. The compounds 4-hydroxytamoxifen and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related mouse phenotypes are digestive/alimentary and limbs/digits/tail.

Aliases & Classifications for Pre-B-Cell Acute Lymphoblastic Leukemia

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47OMIM, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

pre-b-cell acute lymphoblastic leukemia 47
pre b-cell acute lymphoblastic leukemia 62


Related Diseases for Pre-B-Cell Acute Lymphoblastic Leukemia

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17GeneCards, 18GeneDecks
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Diseases related to Pre-B-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 33)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.2ETV6, PBX1, TCF3, TCL1A, BRCA2, IL7R
2severe combined immunodeficiency30.6IL7, IL2RG, IL7R
3lymphoblastic leukemia11.1
4sarcoma10.6
5aleukemic leukemia cutis10.4
6rosai-dorfman disease10.4
7lymphoma aidsrelated10.1IL7, TCL1A
8congenital mesoblastic nephroma10.0ETV6
9human immunodeficiency virus infectious disease10.0IL7R, IL7
10cutaneous t cell lymphoma10.0IL7R, IL7
11gamma chain deficiency10.0IL7, IL2RG, IL7R
12lymphopenia10.0IL7, IL2RG, IL7R
13peripheral t-cell lymphoma10.0ETV6, TCL1A
14acute myelomonocytic leukemia10.0KMT2A, ETV6
15follicular lymphoma10.0KMT2A, TCL1A
16immunodeficiency with hyper igm type 210.0IL7, NR3C1, TCL1A
17myeloproliferative disorder10.0ETV6, KMT2A
18b-cell chronic lymphocytic leukemia10.0KMT2A, BRCA2, TCL1A, IL7
19hodgkin's lymphoma10.0IL7, TCL1A, BRCA2, KMT2A
20chronic lymphocytic leukemia9.9IL7, TCL1A, KMT2A, BRCA2
21myeloma9.9IL7, TCL1A, NR3C1, IL7R
22viral infectious disease9.9NR3C1, IL7R, IL7
23melanoma9.9BRCA2, IL7, IL7R, IL2RG
24leukemia, acute lymphoblastic 39.9IL7, PBX1, ETV6, KMT2A
25acute leukemia9.9PBX1, ETV6, KMT2A, IL7
26non-hodgkin lymphoma9.9IL7, TCL1A, ETV6, KMT2A
27acute lymphoblastic leukemia, childhood9.9KMT2A, IL7, ETV6, NR3C1
28hematologic cancer9.9KMT2A, ETV6, IL7, NR3C1
29prostate cancer9.9PBX1, KMT2A, IL7, BRCA2, NR3C1
30precursor t-cell acute lymphoblastic leukemia9.8NR3C1, IL7, KMT2A, ETV6, IL2RG, IL7R
31burkitt's lymphoma9.8IL7R, TCL1A, IL7, PBX1, ETV6, BRCA2
32acute lymphocytic leukemia9.8TCF3, NR3C1, IL7R, IL7, PBX1, ETV6
33breast cancer9.8KMT2A, NR3C1, IL7R, ETV6, BRCA2, PBX1

Graphical network of the top 20 diseases related to Pre-B-Cell Acute Lymphoblastic Leukemia:



Diseases related to pre-b-cell acute lymphoblastic leukemia

Symptoms for Pre-B-Cell Acute Lymphoblastic Leukemia

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Drugs & Therapeutics for Pre-B-Cell Acute Lymphoblastic Leukemia

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Pre-B-Cell Acute Lymphoblastic Leukemia

Search NIH Clinical Center for Pre-B-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Pre-B-Cell Acute Lymphoblastic Leukemia

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Anatomical Context for Pre-B-Cell Acute Lymphoblastic Leukemia

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33MalaCards
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MalaCards organs/tissues related to Pre-B-Cell Acute Lymphoblastic Leukemia:

33
B cells, T cells, Bone, Bone marrow

Animal Models for Pre-B-Cell Acute Lymphoblastic Leukemia or affiliated genes

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37MGI
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Publications for Pre-B-Cell Acute Lymphoblastic Leukemia

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52PubMed
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Articles related to Pre-B-Cell Acute Lymphoblastic Leukemia:

(show all 29)
idTitleAuthorsYear
1
Recurrent aleukemic leukemia cutis in a patient with pre-B-cell acute lymphoblastic leukemia. (23733764)
2013
2
Mer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia. (23861246)
2013
3
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. (24013638)
2013
4
Role of c-Myb in the survival of pre B-cell acute lymphoblastic leukemia and leukemogenesis. (22764095)
2012
5
Recurrent pre-B-cell acute lymphoblastic leukemia in the middle ear: a form of granulocytic sarcoma. (22829030)
2012
6
A distinct DNA methylation signature defines pediatric pre-B cell acute lymphoblastic leukemia. (22531296)
2012
7
Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia. (21768304)
2011
8
Glucocorticoid receptor knock down reveals a similar apoptotic threshold but differing gene regulation patterns in T-cell and pre-B-cell acute lymphoblastic leukemia. (20170710)
2010
9
IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers. (20060740)
2010
10
Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma. (20049929)
2010
11
ZAP-70 is highly expressed in most cases of childhood pre-B cell acute lymphoblastic leukemia. (18333847)
2008
12
The difference between pre-B cell acute lymphoblastic leukemia and Burkitt lymphoma in relation to DNA damage repair gene polymorphisms in childhood. (18608862)
2008
13
Rosai-Dorfman disease following bone marrow transplantation for pre-B cell acute lymphoblastic leukemia. (18493991)
2008
14
Pre-B-cell acute lymphoblastic leukemia presenting as an orbital mass in an 8-month-old. (16406546)
2006
15
Parvovirus B19 infection presenting as pre-B-cell acute lymphoblastic leukemia: a transient and progressive course in two children. (15454845)
2004
16
Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression. (12127395)
2002
17
Molecular analysis of an unusual rearrangement between chromosomes 4 and 11 in adult pre-B-cell acute lymphoblastic leukemia. (11943339)
2002
18
Mixed chimerism in the B cell lineage is a rapid and sensitive indicator of minimal residual disease in bone marrow transplant recipients with pre-B cell acute lymphoblastic leukemia. (10808205)
2000
19
Translocation (1;13)(p34;q32) in childhood pre-B-cell acute lymphoblastic leukemia. (10991621)
2000
20
Transitional pre-B-cell acute lymphoblastic leukemia in adults. (10440917)
1999
21
A novel t(7;17)(q11;q11) as the sole karyotypic abnormality in childhood pre-B-cell acute lymphoblastic leukemia. (9648563)
1998
22
Frequent expression of human Thy-1 antigen on pre-B cell acute lymphoblastic leukemia with t(9;22). (9695410)
1998
23
Identification of integrated human herpesvirus 6 DNA in early pre-B cell acute lymphoblastic leukemia. (9639436)
1998
24
Transitional pre-B-cell acute lymphoblastic leukemia of childhood is associated with favorable prognostic clinical features and an excellent outcome: a Pediatric Oncology Group study. (8255107)
1993
25
In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency. (1373967)
1992
26
Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19). (2380759)
1990
27
T cell receptor alpha-, beta-, and gamma-genes in T cell and pre-B cell acute lymphoblastic leukemia. (3497178)
1987
28
Pre-B cell acute lymphoblastic leukemia in the newborn. (6593098)
1984
29
Further immunologic characteristics of pre-B-cell acute lymphoblastic leukemia in children. (6602449)
1983

Variations for Pre-B-Cell Acute Lymphoblastic Leukemia

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Pre-B-Cell Acute Lymphoblastic Leukemia:

1
id Gene Name Type Significance SNP ID Assembly Location
1BRCA2NM_000059.3(BRCA2): c.658_659delGT (p.Val220Ilefs)deletionPathogenic, risk factorrs80359604GRCh37Chr 13, 32903606: 32903607
2BRCA2NM_000059.3(BRCA2): c.5645C> G (p.Ser1882Ter)single nucleotide variantPathogenic, risk factorrs80358785GRCh37Chr 13, 32914137: 32914137

Expression for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for Pre-B-Cell Acute Lymphoblastic Leukemia.

Pathways for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 54R&D Systems, 53QIAGEN, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL7R, IL2RG
29.7TCF3, NR3C1
39.7IL7R, IL7
49.5NR3C1, PBX1
5
Show member pathways
9.3IL7, IL2RG, IL7R
6
Show member pathways
Type III interferon signaling38
9.3IL2RG, IL7R, IL7
7
Show member pathways
9.3IL7, IL7R, IL2RG
8
Show member pathways
9.3IL7R, IL7, IL2RG
9
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.3IL7R, IL2RG, IL7
109.2NR3C1, TCF3, PBX1
119.1PBX1, KMT2A
12
Show member pathways
9.0IL2RG, TCF3, IL7, IL7R
13
Show member pathways
9.0IL7R, IL2RG, TCF3, IL7
14
Show member pathways
9.0TCF3, IL2RG, IL7, IL7R
15
Show member pathways
8.9IL7R, NR3C1, IL2RG, IL7
168.7IL2RG, IL7R, IL7, TCL1A
178.3ETV6, PBX1, TCF3, KMT2A

Compounds for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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Sources:
45Novoseek, 3BitterDB, 61Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR, 51PharmGKB
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Compounds related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
14-hydroxytamoxifen459.7NR3C1, BRCA2
2hydrocortisone45 3 61 1112.3NR3C1, IL7, PBX1
3agar459.2NR3C1, IL7, ETV6
4estradiol45 24 1111.1BRCA2, PBX1, IL7, NR3C1
5progesterone45 29 61 24 1113.0BRCA2, PBX1, IL7, NR3C1
6testosterone45 61 24 1112.0NR3C1, IL7, PBX1, BRCA2
7etoposide45 51 61 1112.0KMT2A, BRCA2, NR3C1
8steroid458.9BRCA2, PBX1, IL7, NR3C1
9prednisolone45 29 1110.9KMT2A, ETV6, NR3C1
10genistein45 29 61 3 24 1113.8KMT2A, BRCA2, IL7
11doxorubicin45 51 1110.8NR3C1, IL7, KMT2A
12proline458.6IL7, BRCA2, KMT2A
13estrogen458.2KMT2A, BRCA2, PBX1, IL7, NR3C1
14retinoic acid45 249.2NR3C1, IL7, ETV6, BRCA2, KMT2A
15tyrosine457.8IL2RG, IL7R, IL7, PBX1, ETV6, KMT2A

GO Terms for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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16Gene Ontology
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Cellular components related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057307.6NR3C1, PBX1, ETV6, BRCA2, KMT2A
2cytoplasmGO:0057377.5BRCA2, TCF3, ETV6, PBX1, NR3C1, KMT2A

Biological processes related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1histone H4 acetylationGO:04396710.0BRCA2, TCF3
2interleukin-7-mediated signaling pathwayGO:03811110.0IL2RG, IL7R
3histone H3 acetylationGO:0439669.9BRCA2, TCF3
4positive regulation of B cell proliferationGO:0308909.8IL7, TCF3
5adrenal gland developmentGO:0303259.6PBX1, NR3C1
6embryonic hemopoiesisGO:0351629.3PBX1, KMT2A
7anterior/posterior pattern specificationGO:0099529.1PBX1, KMT2A
8positive regulation of transcription, DNA-templatedGO:0458938.7TCF3, BRCA2, KMT2A
9transcription from RNA polymerase II promoterGO:0063668.6NR3C1, ETV6, KMT2A

Molecular functions related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-7 receptor activityGO:0049179.7IL7R, IL2RG
2sequence-specific DNA bindingGO:0435658.7NR3C1, PBX1, ETV6, TCF3
3sequence-specific DNA binding transcription factor activityGO:0037007.5KMT2A, TCF3, ETV6, PBX1, NR3C1
4protein bindingGO:0055155.8NR3C1, KMT2A, BRCA2, TCL1A, TCF3, ETV6

Products for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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Sources for Pre-B-Cell Acute Lymphoblastic Leukemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet