MCID: PRB001
MIFTS: 40

Pre-B-Cell Acute Lymphoblastic Leukemia malady

Immune diseases category
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Summaries for Pre-B-Cell Acute Lymphoblastic Leukemia

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MalaCards based summary: Pre-B-Cell Acute Lymphoblastic Leukemia, also known as pre b-cell acute lymphoblastic leukemia, is related to severe combined immunodeficiency and acute lymphoblastic leukemia. An important gene associated with Pre-B-Cell Acute Lymphoblastic Leukemia is BRCA2 (breast cancer 2, early onset), and among its related pathways are Primary immunodeficiency and Regulation of nuclear SMAD2/3 signaling. The compounds 4-hydroxytamoxifen and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone marrow, and related mouse phenotypes are digestive/alimentary and limbs/digits/tail.

Aliases & Classifications for Pre-B-Cell Acute Lymphoblastic Leukemia

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Pre-B-Cell Acute Lymphoblastic Leukemia, Aliases & Descriptions:

Name: Pre-B-Cell Acute Lymphoblastic Leukemia 46
 
Pre B-Cell Acute Lymphoblastic Leukemia 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Related Diseases for Pre-B-Cell Acute Lymphoblastic Leukemia

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Diseases in the Pre-B-Cell Acute Lymphoblastic Leukemia family:

Leukemia-2, T-Cell Acute Lymphoblastic

Diseases related to Pre-B-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 33)
idRelated DiseaseScoreTop Affiliating Genes
1severe combined immunodeficiency30.7IL2RG, IL7R, IL7
2acute lymphoblastic leukemia30.4KMT2A, TCF3, ETV6, PBX1, IL7, IL7R
3leukemia29.6NR3C1, KMT2A, BRCA2, TCL1A, TCF3, ETV6
4lymphoblastic leukemia11.1
5sarcoma10.6
6hereditary multiple exostoses10.4
7aleukemic leukemia cutis10.4
8rosai-dorfman disease10.4
9lymphoma aidsrelated10.2IL7, TCL1A
10congenital mesoblastic nephroma10.2ETV6
11human immunodeficiency virus infectious disease10.2IL7R, IL7
12cutaneous t cell lymphoma10.1IL7, IL7R
13gamma chain deficiency10.1IL2RG, IL7R, IL7
14lymphopenia10.1IL2RG, IL7R, IL7
15peripheral t-cell lymphoma10.0ETV6, TCL1A
16acute myelomonocytic leukemia10.0ETV6, KMT2A
17follicular lymphoma10.0TCL1A, KMT2A
18immunodeficiency with hyper igm type 29.9TCL1A, IL7, NR3C1
19bone marrow cancer9.9ETV6, KMT2A
20hodgkin's lymphoma9.8KMT2A, BRCA2, TCL1A, IL7
21chronic lymphocytic leukemia9.8KMT2A, BRCA2, TCL1A, IL7
22myeloma9.8TCL1A, IL7, IL7R, NR3C1
23viral infectious disease9.8IL7, IL7R, NR3C1
24melanoma9.7BRCA2, IL7, IL7R, IL2RG
25leukemia, acute lymphoblastic 39.7IL7, PBX1, ETV6, KMT2A
26acute leukemia9.7KMT2A, ETV6, PBX1, IL7
27non-hodgkin lymphoma9.7KMT2A, TCL1A, ETV6, IL7
28acute lymphoblastic leukemia, childhood9.6KMT2A, ETV6, IL7, NR3C1
29hematologic cancer9.6NR3C1, IL7, ETV6, KMT2A
30prostate cancer9.5KMT2A, BRCA2, PBX1, IL7, NR3C1
31precursor t-cell acute lymphoblastic leukemia9.2KMT2A, ETV6, IL7, IL7R, IL2RG, NR3C1
32burkitt's lymphoma9.2KMT2A, BRCA2, TCL1A, ETV6, PBX1, IL7
33breast cancer9.0KMT2A, BRCA2, ETV6, PBX1, IL7, IL7R

Graphical network of the top 20 diseases related to Pre-B-Cell Acute Lymphoblastic Leukemia:



Diseases related to pre-b-cell acute lymphoblastic leukemia

Symptoms for Pre-B-Cell Acute Lymphoblastic Leukemia

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Drugs & Therapeutics for Pre-B-Cell Acute Lymphoblastic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Pre-B-Cell Acute Lymphoblastic Leukemia

Search NIH Clinical Center for Pre-B-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Pre-B-Cell Acute Lymphoblastic Leukemia

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Anatomical Context for Pre-B-Cell Acute Lymphoblastic Leukemia

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MalaCards organs/tissues related to Pre-B-Cell Acute Lymphoblastic Leukemia:

32
B cells, T cells, Bone marrow, Bone

Animal Models for Pre-B-Cell Acute Lymphoblastic Leukemia or affiliated genes

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Publications for Pre-B-Cell Acute Lymphoblastic Leukemia

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Articles related to Pre-B-Cell Acute Lymphoblastic Leukemia:

(show all 28)
idTitleAuthorsYear
1
Pre-B-cell acute lymphoblastic leukemia in a boy with hereditary multiple exostoses caused by EXT1 deletion. (25116165)
2014
2
Recurrent aleukemic leukemia cutis in a patient with pre-B-cell acute lymphoblastic leukemia. (23733764)
2013
3
Mer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia. (23861246)
2013
4
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. (24013638)
2013
5
Role of c-Myb in the survival of pre B-cell acute lymphoblastic leukemia and leukemogenesis. (22764095)
2012
6
Recurrent pre-B-cell acute lymphoblastic leukemia in the middle ear: a form of granulocytic sarcoma. (22829030)
2012
7
A distinct DNA methylation signature defines pediatric pre-B cell acute lymphoblastic leukemia. (22531296)
2012
8
Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia. (21768304)
2011
9
Glucocorticoid receptor knock down reveals a similar apoptotic threshold but differing gene regulation patterns in T-cell and pre-B-cell acute lymphoblastic leukemia. (20170710)
2010
10
Pre-B-cell acute lymphoblastic leukemia with bulk extramedullary disease and chromosome 22 (EWSR1) rearrangement masquerading as Ewing sarcoma. (20049929)
2010
11
ZAP-70 is highly expressed in most cases of childhood pre-B cell acute lymphoblastic leukemia. (18333847)
2008
12
The difference between pre-B cell acute lymphoblastic leukemia and Burkitt lymphoma in relation to DNA damage repair gene polymorphisms in childhood. (18608862)
2008
13
Rosai-Dorfman disease following bone marrow transplantation for pre-B cell acute lymphoblastic leukemia. (18493991)
2008
14
Pre-B-cell acute lymphoblastic leukemia presenting as an orbital mass in an 8-month-old. (16406546)
2006
15
Parvovirus B19 infection presenting as pre-B-cell acute lymphoblastic leukemia: a transient and progressive course in two children. (15454845)
2004
16
Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression. (12127395)
2002
17
Molecular analysis of an unusual rearrangement between chromosomes 4 and 11 in adult pre-B-cell acute lymphoblastic leukemia. (11943339)
2002
18
Mixed chimerism in the B cell lineage is a rapid and sensitive indicator of minimal residual disease in bone marrow transplant recipients with pre-B cell acute lymphoblastic leukemia. (10808205)
2000
19
Translocation (1;13)(p34;q32) in childhood pre-B-cell acute lymphoblastic leukemia. (10991621)
2000
20
Transitional pre-B-cell acute lymphoblastic leukemia in adults. (10440917)
1999
21
A novel t(7;17)(q11;q11) as the sole karyotypic abnormality in childhood pre-B-cell acute lymphoblastic leukemia. (9648563)
1998
22
Frequent expression of human Thy-1 antigen on pre-B cell acute lymphoblastic leukemia with t(9;22). (9695410)
1998
23
Identification of integrated human herpesvirus 6 DNA in early pre-B cell acute lymphoblastic leukemia. (9639436)
1998
24
Transitional pre-B-cell acute lymphoblastic leukemia of childhood is associated with favorable prognostic clinical features and an excellent outcome: a Pediatric Oncology Group study. (8255107)
1993
25
In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency. (1373967)
1992
26
T cell receptor alpha-, beta-, and gamma-genes in T cell and pre-B cell acute lymphoblastic leukemia. (3497178)
1987
27
Pre-B cell acute lymphoblastic leukemia in the newborn. (6593098)
1984
28
Further immunologic characteristics of pre-B-cell acute lymphoblastic leukemia in children. (6602449)
1983

Variations for Pre-B-Cell Acute Lymphoblastic Leukemia

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Clinvar genetic disease variations for Pre-B-Cell Acute Lymphoblastic Leukemia:

6
id Gene Name Type Significance SNP ID Assembly Location
1BRCA2NM_000059.3(BRCA2): c.658_659delGT (p.Val220Ilefs)deletionPathogenicrs80359604GRCh37Chr 13, 32903606: 32903607
2BRCA2NM_000059.3(BRCA2): c.5645C> G (p.Ser1882Ter)single nucleotide variantPathogenicrs80358785GRCh37Chr 13, 32914137: 32914137

Expression for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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Expression patterns in normal tissues for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for Pre-B-Cell Acute Lymphoblastic Leukemia.

Pathways for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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Pathways related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL2RG, IL7R
29.7NR3C1, TCF3
39.7IL7R, IL7
49.5NR3C1, PBX1
5
Show member pathways
9.3IL2RG, IL7R, IL7
6
Show member pathways
Type III interferon signaling37
9.3IL2RG, IL7R, IL7
7
Show member pathways
9.3IL7, IL7R, IL2RG
8
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.3IL7, IL7R, IL2RG
9
Show member pathways
9.3IL7, IL7R, IL2RG
109.2NR3C1, PBX1, TCF3
119.1KMT2A, PBX1
12
Show member pathways
9.0IL2RG, IL7R, IL7, TCF3
13
Show member pathways
9.0IL2RG, IL7R, IL7, TCF3
14
Show member pathways
9.0TCF3, IL7, IL7R, IL2RG
15
Show member pathways
8.9IL7, IL7R, IL2RG, NR3C1
168.7IL2RG, IL7R, IL7, TCL1A
178.3KMT2A, TCF3, ETV6, PBX1

Compounds for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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Compounds related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
14-hydroxytamoxifen449.7NR3C1, BRCA2
2hydrocortisone44 2 61 1112.3NR3C1, IL7, PBX1
3agar449.2NR3C1, IL7, ETV6
4estradiol44 24 1111.1BRCA2, PBX1, IL7, NR3C1
5progesterone44 28 61 24 1113.0BRCA2, PBX1, IL7, NR3C1
6testosterone44 61 24 1112.0NR3C1, IL7, PBX1, BRCA2
7etoposide44 50 61 1112.0KMT2A, BRCA2, NR3C1
8steroid448.9BRCA2, PBX1, IL7, NR3C1
9prednisolone44 28 1110.9KMT2A, ETV6, NR3C1
10genistein44 28 61 2 24 1113.8KMT2A, BRCA2, IL7
11doxorubicin44 50 1110.8NR3C1, IL7, KMT2A
12proline448.6IL7, BRCA2, KMT2A
13estrogen448.2KMT2A, BRCA2, PBX1, IL7, NR3C1
14retinoic acid44 249.2NR3C1, IL7, ETV6, BRCA2, KMT2A
15tyrosine447.8IL2RG, IL7R, IL7, PBX1, ETV6, KMT2A

GO Terms for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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Cellular components related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057307.6NR3C1, PBX1, ETV6, BRCA2, KMT2A
2cytoplasmGO:0057377.5BRCA2, TCF3, ETV6, PBX1, NR3C1, KMT2A

Biological processes related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1histone H4 acetylationGO:04396710.0BRCA2, TCF3
2interleukin-7-mediated signaling pathwayGO:03811110.0IL2RG, IL7R
3histone H3 acetylationGO:0439669.9BRCA2, TCF3
4positive regulation of B cell proliferationGO:0308909.8IL7, TCF3
5adrenal gland developmentGO:0303259.6PBX1, NR3C1
6embryonic hemopoiesisGO:0351629.3PBX1, KMT2A
7anterior/posterior pattern specificationGO:0099529.1PBX1, KMT2A
8positive regulation of transcription, DNA-templatedGO:0458938.7TCF3, BRCA2, KMT2A
9transcription from RNA polymerase II promoterGO:0063668.6NR3C1, ETV6, KMT2A

Molecular functions related to Pre-B-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-7 receptor activityGO:0049179.7IL7R, IL2RG
2sequence-specific DNA bindingGO:0435658.7NR3C1, PBX1, ETV6, TCF3
3sequence-specific DNA binding transcription factor activityGO:0037007.5KMT2A, TCF3, ETV6, PBX1, NR3C1
4protein bindingGO:0055155.8NR3C1, KMT2A, BRCA2, TCL1A, TCF3, ETV6

Products for genes affiliated with Pre-B-Cell Acute Lymphoblastic Leukemia

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  • Antibodies
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Sources for Pre-B-Cell Acute Lymphoblastic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet