MCID: PRC016
MIFTS: 75

Pre-Eclampsia malady

Reproductive diseases category

Summaries for Pre-Eclampsia

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21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Preeclampsia is a complication of pregnancy in which affected women develop high blood pressure (hypertension) and can also have abnormally high levels of protein in their urine. This condition usually occurs in the last few months of pregnancy and often requires the early delivery of the infant.

MalaCards: Pre-Eclampsia, also known as preeclampsia, is related to eclampsia and severe pre-eclampsia. An important gene associated with Pre-Eclampsia is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are HIF-1 signaling pathway and HIF-1-alpha transcription factor network. The drug magnesium sulfate and the compounds vegf and creatinine have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and testes, and related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:63 Pre-eclampsia or preeclampsia is a multi system disorder characterized by high blood pressure and... more...

Description from OMIM:46 189800,609404,609402,609403,614595

Aliases & Classifications for Pre-Eclampsia

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Sources:
8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 60UMLS, 46OMIM, 44Novoseek, 48Orphanet, 9diseasecard, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

48
preeclampsia:
Prevalence: 1-5/10000


Aliases & Descriptions:

pre-eclampsia 8 21 10 60
preeclampsia 8 21 46 44 48
hypertension induced by pregnancy 8 60
pregnancy-induced hypertension 8 21
toxemia of pregnancy 8 21
proteinuric hypertension of pregnancy 8
gestational proteinuric hypertension 21
pregnancy associated hypertension 8
preeclampsia, susceptibility to 9
hypertension, pregnancy-induced 46
hypertension of pregnancy nos 8
gestational hypertension 8
preeclampsia/eclampsia 8
pre-eclamptic toxaemia 8
toxaemia of pregnancy 8
hypertension of preg. 8
pregnancy toxemias 44
pre-eclamptic nos 8
pregnancy toxemia 8
pre-eclampsia nos 8
toxaemia nos 8
toxemia nos 8


External Ids:

Disease Ontology8 DOID:10591
MeSH34 D011225
SNOMED-CT via Orphanet57 15394000, 398254007
ICD10 via Orphanet26 O14.1, O14.2, O14.9 O13, O14.0, O11, more
ICD1025 O13, O14

Related Diseases for Pre-Eclampsia

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pre-Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 277)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia32.4HLA-G, SERPINC1
2severe pre-eclampsia31.9APOH, HLA-G, F5, IGFBP1, MAOA, LEP
3hypertension31.4F5, AGT, LEP, NOS3, VCAM1, SERPINE1
4hellp syndrome31.2APOH, F5, SERPINE1, SERPINC1, GSTP1
5mild pre-eclampsia31.1SOD1, IGFBP1, VCAM1
6proteinuria30.7APOH, HLA-G, FLT1, AGT, NOS3
7thrombophilia30.7APOH, F5, SERPINE1, SERPINC1
8placental insufficiency30.7FLT1, IGFBP1
9diabetes mellitus30.6SOD1, AGT, IGFBP1, LEP, NOS3, VCAM1
10essential hypertension30.6SOD1, HLA-G, AGT, LEP, NOS3, SERPINE1
11placental abruption30.6SERPINC1, F5
12hepatitis30.6IGFBP1, EPHX1
13obesity30.5FLT1, AGT, IGFBP1, MAOA, LEP, NOS3
14chorioamnionitis30.5FLT1
15pancreatitis30.4SOD1, GSTP1
16breast cancer30.3HLA-G, FLT1, AGT, IGFBP1, EPHX1, LEP
17antiphospholipid syndrome30.3APOH, F5, VCAM1, SERPINC1
18thrombocytopenia30.3APOH, F5, SERPINC1
19lupus erythematosus30.1SERPINC1, F5, APOH
20choriocarcinoma30.1LEP, FLT1, HLA-G
21hyperinsulinism30.1IGFBP1, LEP, SERPINE1
22disseminated intravascular coagulation30.1F5, SERPINE1, SERPINC1
23retinopathy of prematurity30.1FLT1
24vascular disease30.1SOD1, APOH, F5, AGT, NOS3, VCAM1
25diabetic retinopathy30.1SOD1, FLT1, AGT, IGFBP1, NOS3, VCAM1
26hyperglycemia30.1SOD1, AGT, IGFBP1, LEP, NOS3, VCAM1
27ischemia30.1SOD1, FLT1, AGT, NOS3
28polycystic ovary syndrome30.1IGFBP1, LEP, SERPINE1
29alzheimer's disease30.1GSTP1, NOS3, MAOA, SOD1
30retinal vein occlusion30.1SERPINC1, F5, APOH
31antithrombin iii deficiency30.0APOH, F5, SERPINC1
32migraine30.0MAOA, APOH
33vasculitis30.0VCAM1, APOH
34hypogonadism30.0LEP, TAC3
35central retinal vein occlusion30.0F5, APOH
36portal vein thrombosis30.0F5, SERPINC1
37purpura30.0SERPINC1
38glomerulonephritis30.0VCAM1
39acute pancreatitis30.0SOD1
40down syndrome30.0SOD1
41hypothyroidism30.0LEP
42glucose intolerance29.9SERPINE1, LEP, IGFBP1
43atherosclerosis29.7CORIN, SOD1, APOH, FLT1, AGT, LEP
44hyperhomocysteinemia29.7SOD1, APOH, F5, NOS3, VCAM1, SERPINE1
45myocardial infarction29.7SERPINC1, SERPINE1, NOS3, IGFBP1, AGT, F5
46adenoma29.7HLA-G, FLT1, IGFBP1, EPHX1, GSTP1
47leukemia29.7HLA-G, FLT1, IGFBP1, EPHX1, GSTP1
48chronic kidney failure29.7NOS3, LEP, IGFBP1, AGT, SOD1
49endometriosis29.7HLA-G, FLT1, IGFBP1
50infertility29.7HLA-G, IGFBP1, LEP

Graphical network of the top 20 diseases related to Pre-Eclampsia:



Diseases related to pre-eclampsia

Clinical Features for Pre-Eclampsia

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

189800,609404,609402,609403,614595

Clinical synopsis from OMIM:

189800

Drugs & Therapeutics for Pre-Eclampsia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pre-Eclampsia

Drug clinical trials:

Search ClinicalTrials for Pre-Eclampsia

Search NIH Clinical Center for Pre-Eclampsia

Search CenterWatch for Pre-Eclampsia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pre-Eclampsia

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Anatomical Context for Pre-Eclampsia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pre-Eclampsia:

32
Placenta, Endothelial, Testes, Liver, Nk cells, T cells, Kidney, Breast, Pancreas, Myeloid, Thyroid, Heart, Brain, Skin, Ovary, Colon, Retina, Pituitary, Lung, B cells, Whole blood, Monocytes, Fetal lung

Animal Models for Pre-Eclampsia or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pre-Eclampsia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.3SERPINC1, CORIN, SOD1, APOH, HLA-G, EGLN2
2MP:000538711.7SOD1, HLA-G, EGLN2, FLT1, AGT, IGFBP1
3MP:001076811.7APOH, FLT1, F5, AGT, TAC3, LEP
4MP:000538511.6CORIN, SOD1, EGLN2, FLT1, AGT, MAOA
5MP:000537011.6SOD1, EGLN2, F5, AGT, IGFBP1, LEP
6MP:000539711.4SOD1, HLA-G, EGLN2, FLT1, LEP, NOS3
7MP:000536910.9CORIN, SOD1, EGLN2, FLT1, AGT, LEP
8MP:000538910.7EGLN2, FLT1, SERPINC1

Publications for Pre-Eclampsia

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Sources:
50PubMed
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Articles related to Pre-Eclampsia:

(show top 50)    (show all 1252)
idTitleAuthorsYear
1
Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia. (24418062)
2014
2
Uterine artery Doppler and sFlt-1/PlGF ratio: usefulness in diagnosis of pre-eclampsia. (23303638)
2013
3
Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation. (23888485)
2013
4
Use of magnesium sulfate for treatment of pre-eclampsia and eclampsia in Mexico. (23465851)
2013
5
Cardiovascular haemodynamics in pre-eclampsia using brain naturetic peptide and tissue Doppler studies. (24217044)
2013
6
Group B streptococcal colonization and the risk of pre-eclampsia. (22813482)
2013
7
Cardiovascular function in women with recurrent miscarriage, pre-eclampsia and/or intrauterine growth restriction. (23039814)
2013
8
eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. (22282588)
2012
9
Pre-eclampsia/eclampsia and hepatic rupture. (22717416)
2012
10
Association of single nucleotide polymorphisms in the human tumor necrosis factor-I+ and interleukin 1-I^ genes in patients with pre-eclampsia. (22947907)
2012
11
Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis. (23132613)
2012
12
Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia--a case-control study. (21534854)
2011
13
Renal hematoma: an unusual cause of acute abdomen and fetal demise in severe pre-eclampsia. (23511047)
2011
14
Comparison between pulse waveform analysis and thermodilution cardiac output determination in patients with severe pre-eclampsia. (21097487)
2011
15
Tissue factor dependent pathway and the diagnosis of pre-eclampsia. (21370212)
2011
16
Induction of labour improves maternal outcomes compared with expectant monitoring in women with gestational hypertension or mild pre-eclampsia. (20176870)
2010
17
The role of urinary soluble endoglin in the diagnosis of pre-eclampsia: comparison with soluble fms-like tyrosine kinase 1 to placental growth factor ratio. (19943826)
2010
18
Vasohibin and VEGF protein levels in placentae from pregnancies complicated by severe pre-eclampsia]. (21302448)
2010
19
Gene expression profiling of placentas affected by pre-eclampsia. (20204130)
2010
20
Association between urotensin II gene polymorphism and pre-eclampsia. (20653105)
2010
21
Relationship between changes of endogenous nitric oxide synthase inhibitor and hydrolase and initiation of pre-eclampsia]. (19570459)
2009
22
Utero-placental haemodynamics in the pathogenesis of pre-eclampsia. (19497617)
2009
23
Polymorphism of HLA-A and HLA-B in pre-eclampsia. (19727231)
2009
24
STOX1 gene in pre-eclampsia and intrauterine growth restriction. (17617193)
2007
25
Placental ABCA1 expression is reduced in primary antiphospholipid syndrome compared to pre-eclampsia and controls. (17113147)
2007
26
Low urinary placental growth factor is a marker of pre-eclampsia. (16395263)
2006
27
Oxidative stress markers and antioxidant levels in normal pregnancy and pre-eclampsia. (16730727)
2006
28
Excessive stimulation of poly(ADP-ribosyl)ation contributes to endothelial dysfunction in pre-eclampsia. (15778700)
2005
29
A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia. (15775999)
2005
30
Haplotypic association of DDAH1 with susceptibility to pre-eclampsia. (15501905)
2005
31
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. (14673478)
2004
32
Emergency management of eclampsia and severe pre-eclampsia. (14631704)
2003
33
Spontaneous renal subcapsular haematoma and acute renal failure complicated by severe pre-eclampsia. (12584299)
2003
34
Massive ascites in severe pre-eclampsia: a rare complication. (12452261)
2002
35
Leptin and pre-eclampsia in black African parturients. (12452464)
2002
36
A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. (11283205)
2001
37
Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. (10866201)
2000
38
Elevated soluble adhesion molecules in women with pre-eclampsia. Do cytokines like tumour necrosis factor-alpha and interleukin-1beta cause endothelial activation. (10471140)
1999
39
Nucleated red blood cells in fetuses delivered for early onset severe pre-eclampsia. (10189031)
1999
40
Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor. (10492869)
1999
41
Soluble adhesion molecules in patients with pre-eclampsia]. (9659698)
1998
42
Flow cytometric detection of activated platelets in pregnant women prior to the development of pre-eclampsia. (8560414)
1995
43
Haemostatic, fibrinolytic and endothelial variables in normal pregnancies and pre-eclampsia. (8018635)
1994
44
Evidence against a pathogenetic role for endothelin in pre-eclampsia. (1384688)
1992
45
Hemostasis and pre-eclampsia]. (2055397)
1991
46
Association between susceptibility to pre-eclampsia within families and HLA DR4. (2572795)
1989
47
Preliminary report on the use of magnesium sulfate in cases of severe pre-eclampsia and eclampsia. (3834084)
1985
48
Autonomic nervous dysfunction in severe pre-eclampsia. (4018366)
1985
49
HLA antigens in severe pre-eclampsia. (79762)
1978
50
Evaluation of a diuretic substance in the management of mild pre-eclampsia; a report of 47 clinical trials. (13595009)
1958

Genetic Variations for Pre-Eclampsia

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Expression for genes affiliated with Pre-Eclampsia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pre-Eclampsia

Search GEO for disease gene expression data for Pre-Eclampsia.

Pathways for genes affiliated with Pre-Eclampsia

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 49PharmGKB
See all sources

Compounds for genes affiliated with Pre-Eclampsia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
See all sources

Compounds related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1vegf4412.3APOH, AGT, F5, EGLN2, HLA-G, IGFBP1
2creatinine4412.1SERPINC1, F5, SOD1, APOH, HLA-G, FLT1
3arginine4412.1APOH, EPHX1, LEP, NOS3, F5, AGT
4prostacyclin4412.0SOD1, LEP, SERPINC1, SERPINE1, VCAM1, NOS3
5cholesterol44 28 11 2415.0IGFBP1, FLT1, APOH, HLA-G, F5, AGT
6nitric oxide44 11 2414.0SOD1, TAC3, IGFBP1, APOH, FLT1, AGT
7cysteine4411.8LEP, HLA-G, F5, SOD1, AGT, IGFBP1
8ascorbic acid44 2412.8EGLN2, LEP, SOD1, F5, MAOA, NOS3
9fibrinogen4411.8SERPINC1, VCAM1, LEP, AGT, IGFBP1, F5
10testosterone44 59 11 2414.7IGFBP1, MAOA, F5, LEP, VCAM1, GSTP1
11lipid4411.7IGFBP1, FLT1, HLA-G, APOH, AGT, SOD1
12homocysteine44 2412.7AGT, VCAM1, APOH, F5, NOS3, SERPINE1
13superoxide44 2412.7AGT, EPHX1, TAC3, NOS3, VCAM1, APOH
14phosphatidylinositol4411.6NOS3, LEP, EPHX1, IGFBP1, APOH, FLT1
15genistein44 28 59 2 11 2416.6VCAM1, NOS3, AGT, FLT1, IGFBP1, SERPINE1
168-isoprostane4411.6LEP, SOD1, APOH, VCAM1, NOS3, SERPINE1
17lactate4411.6SOD1, HLA-G, APOH, GSTP1, VCAM1, F5
18oxygen44 2412.6FLT1, AGT, IGFBP1, MAOA, EGLN2, HLA-G
19folate4411.5VCAM1, APOH, NOS3, F5, GSTP1, SERPINC1
20aspirin44 49 28 2414.5F5, APOH, NOS3, SERPINE1, SERPINC1, GSTP1
21methotrexate44 49 1113.5SERPINE1, GSTP1, APOH, NOS3, HLA-G, LEP
22epinephrine44 11 2413.4GSTP1, LEP, MAOA, IGFBP1, AGT, F5
23n(g)-nitro-l-arginine methyl ester4411.4AGT, LEP, NOS3, SERPINE1, SOD1
24p0034411.4EPHX1, SERPINE1, APOH, FLT1, HLA-G
25l-nmma4411.4NOS3, AGT, LEP, VCAM1, SOD1
26n acetylcysteine4411.4GSTP1, SERPINC1, VCAM1, LEP, AGT, SOD1
27progesterone44 59 28 11 2415.4IGFBP1, LEP, SERPINE1, F5, APOH, HLA-G
28sodium nitroprusside4411.3SERPINE1, VCAM1, NOS3, SOD1, LEP
29heparin44 28 11 2414.3APOH, FLT1, AGT, VCAM1
30atorvastatin44 49 28 11 2415.3NOS3, VCAM1, SERPINE1, AGT, F5
31cyclophosphamide44 49 1113.3NOS3, APOH, F5, GSTP1
32serine4411.3CORIN, FLT1, LEP, AGT
33p0024411.3APOH, FLT1, IGFBP1, LEP, F5
34tibolone4411.3SERPINE1, F5, LEP, SERPINC1
35apocynin44 5912.3VCAM1, AGT, SOD1, NOS3
36amlodipine44 49 11 2414.3AGT, NOS3, VCAM1, SERPINE1
37simvastatin44 49 59 28 11 2416.2F5, SERPINE1, VCAM1, NOS3, AGT
38tamoxifen44 49 28 1114.2EPHX1, VCAM1, IGFBP1
39uric acid44 2412.2APOH, F5, SERPINE1
40estrogen4411.1TAC3, APOH
41rosiglitazone44 49 28 11 2415.1IGFBP1, VCAM1, LEP
42ancrod4411.0F5, SERPINE1, SERPINC1
43dexamethasone44 49 28 1114.0MAOA, AGT
44raloxifene44 28 49 1114.0SERPINE1, SERPINC1, F5, NOS3
45fenofibrate44 49 1112.9LEP, NOS3, SERPINE1, VCAM1
46glutathion4410.8EPHX1, GSTP1
47h2o24410.8FLT1, AGT, MAOA, LEP
48warfarin44 49 11 2413.8SERPINC1, EPHX1, APOH
49diphenyleneiodonium4410.8VCAM1, SOD1
50coumarins4410.4MAOA, APOH

GO Terms for genes affiliated with Pre-Eclampsia

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Sources:
16Gene Ontology
See all sources

Cellular components related to Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4SERPINE1, LEP, TAC3, IGFBP1, AGT, F5
2extracellular spaceGO:00561511.4SOD1, VCAM1, LEP, TAC3, IGFBP1, AGT

Biological processes related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.2SOD1, F5, NOS3, SERPINE1, SERPINC1
2regulation of blood pressureGO:00821711.2CORIN, SOD1, LEP, NOS3
3positive regulation of superoxide anion generationGO:03293011.1GSTP1, AGT, SOD1
4positive regulation of cytokine productionGO:00181911.1LEP, AGT, SOD1
5negative regulation of endopeptidase activityGO:01095111.1SERPINC1, SERPINE1, AGT
6positive regulation of MAPK cascadeGO:04341011.0LEP, AGT, FLT1
7female pregnancyGO:00756511.0CORIN, TAC3, LEP
8regulation of renal sodium excretionGO:03581311.0CORIN, AGT
9ovulation from ovarian follicleGO:00154210.9NOS3, LEP
10platelet degranulationGO:00257610.9SOD1, F5, SERPINE1
11negative regulation of fibrinolysisGO:05191810.8SERPINE1, APOH
12negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.8SERPINE1, NOS3
13leukocyte tethering or rollingGO:05090110.7LEP, VCAM1
14negative regulation of blood coagulationGO:03019510.7SERPINE1, APOH
15positive regulation of blood coagulationGO:03019410.6APOH, SERPINE1
16positive regulation of angiogenesisGO:04576610.5FLT1, NOS3, SERPINE1

Molecular functions related to Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.8SERPINC1, SERPINE1, AGT
2primary amine oxidase activityGO:00813110.4VCAM1, MAOA

Products for genes affiliated with Pre-Eclampsia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pre-Eclampsia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet