MCID: PRC016
MIFTS: 58

Pre-Eclampsia malady

Rare diseases category

Summaries for Pre-Eclampsia

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Wikipedia:63 Pre-eclampsia or preeclampsia (PE) is a disorder of pregnancy characterized by high blood pressure and a... more...

MalaCards based summary: Pre-Eclampsia, also known as hypertension induced by pregnancy, is related to eclampsia and mild pre-eclampsia. An important gene associated with Pre-Eclampsia is STOX1 (storkhead box 1), and among its related pathways are Glypican 1 network and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The drug magnesium sulfate and the compounds ancrod and n(g)-nitro-l-arginine methyl ester have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and liver, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Disease Ontology:9 A hypertension occurring during pregnancy also characterized by large amounts of protein in the urine.

Aliases & Classifications for Pre-Eclampsia

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Pre-Eclampsia, Aliases & Descriptions:

Name: Pre-Eclampsia 9 11 60
Hypertension Induced by Pregnancy 9 60
Proteinuric Hypertension of Pregnancy 9
Transient Hypertension of Pregnancy 60
Pregnancy Associated Hypertension 9
Gestational Hypertension 9
 
Pre-Eclamptic Toxaemia 9
Preeclampsia/eclampsia 9
Toxaemia of Pregnancy 9
Pregnancy Toxemia 9
Preeclampsia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Pre-Eclampsia

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Diseases in the Eclampsia family:

pre-eclampsia Severe Pre-Eclampsia

Diseases related to Pre-Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia33.0SERPINC1, HLA-G
2mild pre-eclampsia31.6IGFBP1, SOD1, VCAM1
3placental insufficiency31.3IGFBP1, PGF, FLT1
4placental abruption31.2SERPINC1, F5
5proteinuria31.0HLA-G, APOH, PGF, FLT1
6hellp syndrome31.0APOH, SERPINE1, SERPINC1, GSTP1, F5
7bronchopulmonary dysplasia30.8FLT1, SOD1
8vascular disease30.8APOH, SERPINC1
9thrombophilia30.7APOH, SERPINE1, SERPINC1, F5
10purpura30.7SERPINC1
11central retinal vein occlusion30.7F5, APOH
12choriocarcinoma30.6HLA-G, LEP, PGF, FLT1
13kidney disease30.6SERPINE1, SERPINC1, VCAM1
14thrombophlebitis30.6APOH
15antiphospholipid syndrome30.6APOH, SERPINC1, VCAM1, F5
16portal vein thrombosis30.6F5, SERPINC1
17polycystic ovary syndrome30.5SERPINE1, LEP, IGFBP1
18thrombocytopenia30.5F5, SERPINC1, APOH
19obesity30.4IGFBP1, LEP, SERPINE1, FLT1, MAOA
20glucose intolerance30.4IGFBP1, LEP, SERPINE1
21infertility30.4IGFBP1, HLA-G, LEP
22retinal vein occlusion30.4F5, SERPINC1, APOH
23lupus erythematosus30.4F5, SERPINC1, APOH
24severe pre-eclampsia30.3MAOA, VCAM1, PGF, SERPINC1, SERPINE1, APOH
25hyperglycemia30.2IGFBP1, LEP, SERPINE1, SOD1, VCAM1
26endometriosis30.1IGFBP1, HLA-G, PGF, FLT1
27breast cancer29.9GSTP1, FLT1, PGF, SERPINE1, LEP, HLA-G
28protein s deficiency29.8APOH, SERPINE1, SERPINC1, F5
29thrombophilia due to activated protein c resistance29.8F5, SERPINC1, SERPINE1, APOH
30myocardial infarction29.7IGFBP1, SERPINE1, SERPINC1, PGF, F5
31hyperhomocysteinemia29.5APOH, SERPINE1, SERPINC1, SOD1, VCAM1, F5
32adenoma29.5IGFBP1, HLA-G, FLT1, GSTP1
33atherosclerosis29.2LEP, APOH, SERPINE1, SERPINC1, SOD1, PGF
34preeclampsia/eclampsia 128.9TAC3, F5, MAOA, VCAM1, FLT1, PGF
35endotheliitis11.0
36hypoxia10.7
37cerebritis10.6
38blindness10.6
39familial hypertension10.6
40eales disease10.5SOD1
41retinal artery occlusion10.5APOH
42branch retinal artery occlusion10.5F5
43retinitis10.5
44carotid artery thrombosis10.5SERPINE1
45periodontitis10.4
46retinal vasculitis10.4APOH
47placenta praevia10.4
48hepatitis10.4
49peripartum cardiomyopathy10.4
50cortical blindness10.4

Graphical network of the top 20 diseases related to Pre-Eclampsia:



Diseases related to pre-eclampsia

Symptoms for Pre-Eclampsia

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Drugs & Therapeutics for Pre-Eclampsia

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Drug clinical trials:

Search ClinicalTrials for Pre-Eclampsia

Search NIH Clinical Center for Pre-Eclampsia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Pre-Eclampsia

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Anatomical Context for Pre-Eclampsia

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MalaCards organs/tissues related to Pre-Eclampsia:

31
Placenta, Endothelial, Liver, Kidney, Lung, Testes, Neutrophil, Nk cells, Breast, T cells, Brain, Heart, Pancreas, Thyroid, Myeloid, Monocytes, Whole blood, Retina, Colon, Skin, Ovary, B cells, Fetal lung, Pituitary

Animal Models for Pre-Eclampsia or affiliated genes

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MGI Mouse Phenotypes related to Pre-Eclampsia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4IGFBP1, LEP, SERPINE1, SERPINC1, SOD1, F5
2MP:00053978.1HLA-G, LEP, SERPINE1, SERPINC1, SOD1, FLT1
3MP:00107718.0SERPINE1, PGF, GSTP1, F5, EGLN2, LEP
4MP:00053807.9LEP, SERPINC1, PGF, FLT1, VCAM1, F5
5MP:00107687.8LEP, APOH, SERPINE1, SERPINC1, SOD1, FLT1
6MP:00053877.2SERPINE1, LEP, HLA-G, IGFBP1, SERPINC1, SOD1
7MP:00053857.1SOD1, SERPINC1, SERPINE1, LEP, PGF, FLT1
8MP:00053766.5EGLN2, HLA-G, LEP, APOH, SERPINE1, SERPINC1

Publications for Pre-Eclampsia

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Articles related to Pre-Eclampsia:

(show top 50)    (show all 1289)
idTitleAuthorsYear
1
Comparison of serum maternal adiponectin concentrations in women with isolated intrauterine growth retardation and intrauterine growth retardation concomitant with pre-eclampsia. (25317046)
2014
2
A report from #BlueJC: Can measuring angiogenic factors help with predicting preterm pre-eclampsia in low-risk women? (24428457)
2014
3
Pre-eclampsia or chronic kidney disease? The flow hypothesis. (23314318)
2013
4
A case-control study of placental lesions associated with pre-eclampsia. (23200099)
2013
5
Aspirin for pre-eclampsia: beware of subgroup meta-analysis. (23610032)
2013
6
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
7
Uterine artery Doppler and sFlt-1/PlGF ratio: usefulness in diagnosis of pre-eclampsia. (23303638)
2013
8
Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women. (22540831)
2012
9
Improving diagnosis and clinical management of pre-eclampsia. (22452158)
2012
10
Hemodynamic evaluation and anti-hypertensive schemes used in puerperal women following pre-eclampsia. (22561779)
2012
11
Unilateral focal renal artery stenosis complicated by early onset superimposed pre-eclampsia. (22663329)
2012
12
Contribution of PARP to endothelial dysfunction and hypertension in a rat model of pre-eclampsia. (22339234)
2012
13
Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia--a case-control study. (21534854)
2011
14
An unexpected tail of VEGF and PlGF in pre-eclampsia. (22103490)
2011
15
Fractional excretion of urea in pre-eclampsia: a clinical observation. (22057072)
2011
16
Aortic intima-media thickness and lipid profile in neonates born to mothers with pre-eclampsia: weak or strong relations? (21932615)
2011
17
A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes. (21340620)
2011
18
Plasminogen activator inhibitor-1 gene polymorphisms in pre-eclampsia. (21370208)
2011
19
A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women. (21973132)
2011
20
Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. (21946915)
2011
21
PP13 as a marker of pre-eclampsia: A two platform comparison study. (21257081)
2011
22
Gene modification with integrin-linked kinase improves function of endothelial progenitor cells in pre-eclampsia in vitro. (21688303)
2011
23
Quantitative detection of the hypermethylated RASSF1A gene in maternal plasma of pre-eclampsia]. (20140873)
2010
24
Role of inflammatory cytokines and eNOS gene polymorphism in pathophysiology of pre-eclampsia. (20047583)
2010
25
Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (19108943)
2009
26
Profile of serum soluble endoglin in pregnant women with severe pre-eclampsia and eclampsia]. (19570416)
2009
27
Urgent termination of pregnancy in pre-eclampsia and panel of antiphospholipid antibodies. (19895376)
2009
28
Predictors and risk factors of pre-eclampsia. (18854808)
2008
29
The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell-free DNA and mRNA in normal pregnancy and pre-eclampsia. (18834630)
2008
30
Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia. (18226121)
2008
31
ADAM12s in maternal serum as a potential marker of pre-eclampsia. (18264967)
2008
32
Altered plasma neurokinin B levels in patients with pre-eclampsia. (17318561)
2007
33
Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes. (17167268)
2007
34
Overproduction of the follistatin-related gene protein in the placenta and maternal serum of women with pre-eclampsia. (17617189)
2007
35
Association between a functional dopamine D4 receptor promoter region polymorphism (-C521T) and pre-eclampsia: a family-based study. (16455620)
2006
36
Three mechanisms in the pathogenesis of pre-eclampsia suggested by over-represented transcription factor-binding sites detected with comparative promoter analysis. (16403800)
2006
37
Oxidative stress is closely related to clinical severity of pre-eclampsia. (16874398)
2006
38
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. (15280126)
2004
39
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. (14673478)
2004
40
Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study. (12653685)
2003
41
Soluble adhesion molecules: marker of pre-eclampsia and intrauterine growth restriction. (12422906)
2002
42
Oxidant stress in pre-eclampsia and essential hypertension. (12583464)
2002
43
Activation of the novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia. (11554693)
2001
44
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. (10965192)
2000
45
Neutrophil CD11B expression and neutrophil activation in pre-eclampsia. (9038589)
1997
46
Endothelin-1 stimulates the proliferation and invasion of first trimester trophoblastic cells in vitro--a possible role in the etiology of pre-eclampsia? (8952225)
1996
47
Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension. (8730885)
1996
48
The effect of severe pre-eclampsia on the pancreas: changes in the serum cationic trypsinogen and pancreatic amylase. (2447935)
1987
49
Severe pre-eclampsia of early onset. (6196074)
1983
50
The management of severe pre-eclampsia. (1050623)
1976

Variations for Pre-Eclampsia

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Expression for genes affiliated with Pre-Eclampsia

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Search GEO for disease gene expression data for Pre-Eclampsia.

Pathways for genes affiliated with Pre-Eclampsia

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Compounds for genes affiliated with Pre-Eclampsia

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Compounds related to Pre-Eclampsia according to GeneCards Suite gene sharing:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1ancrod439.9F5, SERPINC1, SERPINE1
2n(g)-nitro-l-arginine methyl ester439.9LEP, SERPINE1, SOD1
3coumarins439.8MAOA, F5, APOH
4pioglitazone28 43 49 1212.8SERPINE1, VCAM1, IGFBP1, LEP
5metformin43 49 1211.8F5, LEP, IGFBP1, SERPINE1
6lycopene43 2410.7GSTP1, VCAM1, SOD1
7tibolone439.7LEP, SERPINE1, SERPINC1, F5
8alpha tocopherol439.6SOD1, APOH, LEP, VCAM1
9sodium nitroprusside439.6VCAM1, LEP, SERPINE1, SOD1
10progestin439.6F5, SERPINE1, SERPINC1, IGFBP1
11kininogen439.6SERPINC1, APOH, F5, SERPINE1
12p002439.6LEP, F5, FLT1, APOH, IGFBP1
138-isoprostane439.6SOD1, SERPINE1, APOH, LEP, VCAM1
14levonorgestrel43 59 28 1212.5SERPINC1, IGFBP1, F5
15p003439.5LEP, HLA-G, APOH, SERPINE1, FLT1
16uric acid43 2410.5F5, SOD1, SERPINE1, LEP, APOH
17gnrh439.5IGFBP1, LEP, SERPINE1, SERPINC1, TAC3
18rosiglitazone28 43 49 24 1213.5SERPINE1, LEP, IGFBP1, VCAM1
19homocysteine43 2410.4F5, VCAM1, SERPINC1, SERPINE1, APOH
20tamoxifen43 49 28 1212.4F5, IGFBP1, VCAM1, SERPINC1, LEP
21cyclophosphamide43 49 1211.3SERPINE1, F5, GSTP1, VCAM1, APOH
22folate439.3F5, GSTP1, VCAM1, SERPINC1, APOH
23n acetylcysteine439.3LEP, SERPINC1, SOD1, VCAM1, GSTP1
24methotrexate49 43 1211.3APOH, SERPINE1, GSTP1, LEP, HLA-G
25superoxide43 2410.2TAC3, VCAM1, GSTP1, SOD1, APOH, FLT1
26epinephrine43 24 1211.2GSTP1, MAOA, LEP, IGFBP1, F5
27aspirin43 49 28 2412.2SERPINC1, APOH, SERPINE1, GSTP1, F5
28cocaine43 1210.1VCAM1, APOH, LEP, F5
29progesterone43 28 59 24 1213.0IGFBP1, HLA-G, LEP, APOH, FLT1, F5
30lactate439.0APOH, F5, GSTP1, VCAM1, HLA-G, IGFBP1
31matrigel439.0PGF, HLA-G, SERPINE1, VCAM1, FLT1
32atorvastatin43 49 28 24 1213.0PGF, VCAM1, F5, SERPINE1
33fibrinogen438.9VCAM1, SERPINC1, F5, APOH, IGFBP1, SERPINE1
34dexamethasone43 49 28 1211.8HLA-G, LEP, SERPINE1, IGFBP1, SERPINC1, VCAM1
35cholesterol43 28 24 1211.8VCAM1, LEP, IGFBP1, APOH, SERPINE1, FLT1
36arginine438.6GSTP1, SOD1, SERPINC1, APOH, F5, LEP
37cysteine438.6GSTP1, IGFBP1, HLA-G, MAOA, SOD1, VCAM1
38paraffin438.6LEP, PGF, FLT1, GSTP1, VCAM1
39ascorbic acid43 249.5MAOA, GSTP1, EGLN2, LEP, SERPINC1, SOD1
40testosterone43 59 24 1211.5IGFBP1, LEP, SERPINE1, SERPINC1, F5, VCAM1
41serine438.4F5, GSTP1, VCAM1, SERPINC1, SERPINE1, LEP
42glucose438.3APOH, LEP, IGFBP1, SERPINE1, PGF, VCAM1
43nitric oxide43 24 1210.1APOH, SERPINE1, SOD1, PGF, VCAM1, F5
44lipid438.0PGF, IGFBP1, HLA-G, FLT1, SERPINE1, SOD1
45heparin43 28 24 1210.9FLT1, VCAM1, F5, PGF, SERPINE1, APOH
46prostacyclin437.9SERPINE1, F5, SERPINC1, SOD1, PGF, FLT1
47estrogen437.8IGFBP1, F5, LEP, APOH, TAC3, GSTP1
48oxygen43 248.7IGFBP1, EGLN2, VCAM1, FLT1, PGF, APOH
49creatinine437.3IGFBP1, GSTP1, FLT1, PGF, SERPINE1, LEP
50vegf436.8HLA-G, PGF, SERPINC1, SERPINE1, APOH, LEP

GO Terms for genes affiliated with Pre-Eclampsia

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Cellular components related to Pre-Eclampsia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310129.6SOD1, SERPINE1, APOH
2extracellular regionGO:00055767.0IGFBP1, LEP, SERPINE1, SERPINC1, SOD1, PGF
3extracellular spaceGO:00056156.6TAC3, IGFBP1, LEP, APOH, SERPINE1, SERPINC1

Biological processes related to Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:005090110.2LEP, VCAM1
2positive regulation of superoxide anion generationGO:003293010.1SOD1, GSTP1
3negative regulation of fibrinolysisGO:005191810.1SERPINE1, APOH
4cellular response to vascular endothelial growth factor stimulusGO:003592410.0FLT1, VCAM1
5positive regulation of cytokine productionGO:000181910.0SOD1, LEP
6positive regulation of blood coagulationGO:003019410.0SERPINE1, APOH
7negative regulation of blood coagulationGO:003019510.0SERPINE1, APOH
8platelet degranulationGO:00025769.9F5, SOD1, SERPINE1
9female pregnancyGO:00075659.4LEP, PGF, TAC3
10positive regulation of angiogenesisGO:00457669.4FLT1, PGF, SERPINE1
11sprouting angiogenesisGO:00020409.3FLT1, PGF
12blood coagulationGO:00075969.3F5, SOD1, SERPINC1, SERPINE1
13vascular endothelial growth factor receptor signaling pathwayGO:00480109.1FLT1, PGF
14response to hypoxiaGO:00016669.0EGLN2, VCAM1, PGF, LEP

Molecular functions related to Pre-Eclampsia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00081319.7MAOA, VCAM1
2insulin-like growth factor bindingGO:00055209.7HTRA4, IGFBP1
3heparin bindingGO:00082018.7PGF, SERPINC1, APOH

Products for genes affiliated with Pre-Eclampsia

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Sources for Pre-Eclampsia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet