Pre-eclampsia malady

Wikipedia: Pre-eclamps or preeclampsia is a medical condition in which hypertension arises in pregnancy...⁴⁴ more...

MalaCards: Pre-eclampsia, also known as preeclampsia, is related to eclampsia and severe pre-eclampsia. An important gene associated with Pre-eclampsia is PIH (pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)), and among its related pathways are Cell adhesion molecules (CAMs) and Antigen processing and presentation. The drugs bendroflumethiazide and diltiazem and the compounds forskolin and heparin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and kidney, and related mouse phenotypes are respiratory system and hematopoietic system.

OMIM: 189800

Aliases & Descriptions:

pre-eclampsia 6 8 43 preeclampsia 6 33 32 hypertension induced by pregnancy 6 43 preeclampsia/eclampsia 6 7 pregnancy-induced hypertension (disorder) 6 hypertension of pregnancy nos (disorder) 6 proteinuric hypertension of pregnancy 6 gestational hypertension (disorder) 6 pregnancy associated hypertension 6 toxemia of pregnancy (disorder) 6 hypertension, pregnancy-induced 33 hypertension of pregnancy nos 6 pre-eclampsia nos (disorder) 6

gestational hypertension 6 pre-eclampsia (disorder) 6 toxemia nos (disorder) 6 pre-eclamptic toxaemia 6 hypertension of preg. 6 toxaemia of pregnancy 6 hypertensive disease 43 toxemia of pregnancy 6 pregnancy toxemias 32 pregnancy toxemia 6 pre-eclamptic nos 6 pre-eclampsia nos 6 toxaemia nos 6

Diseases related to pre-eclampsia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 982)

id	Related Disease	Score	Top Affiliating Genes
1	eclampsia	46.8	PIGF, PIH, REN, CNR1, KISS1, KIR3DL2
2	severe pre-eclampsia	42.9	SELP, SERPINC1, SERPINE1, VEGFA, VCAM1, VASH1
3	hellp syndrome	36.3	VWF, SERPINC1, SERPINE1, VEGFA, PAPPA2, LGALS13
4	hypertension	33.8	PIH, REN, CNR1, KISS1, VWF, SELE
5	placental abruption	32.8	SERPINC1, LNPEP, PAPPA, MTHFR, INHA, IL1RN
6	essential hypertension	32.5	REN, KISS1, VWF, SELE, SELL, SELP
7	placental insufficiency	31.5	VWF, LNPEP, PAPPA, LEP, CGA, FLT1
8	thrombophilia	31.3	VWF, SELE, SELP, SERPINC1, SERPINE1, MTHFR
9	gestational diabetes	31.3	NAMPT, PAPPA, LEP, LEPR, INS, IGFBP1
10	hyperlipidemia	31.1	VWF, SELP, SERPINC1, SERPINB2, SERPINE1, NAMPT
11	antiphospholipid syndrome	30.9	VWF, SELE, SELP, SERPINC1, SERPINE1, VEGFA
12	retinol binding protein	30.8	NAMPT, LEP, LCN2, XDH, B2M, INS
13	spontaneous abortion	30.5	KIR3DL2, KIR2DL4, KIR3DL1, SELP, SERPINC1, SERPINE1
14	cholestasis	30.4	CNR1, SERPINC1, VEGFA, LPL, AVP, MPO
15	hypoxia	30.3	PIGF, REN, VWF, GCM1, SELE, SELL
16	hepatitis	30.1	SELP, XDH, FASLG, FAS, GPT, F2
17	portal hypertension	29.9	CNR1, UTS2, MAOA, GPT, F2, ALB
18	proteinuria	29.8	REN, VWF, SELL, SELP, SERPINC1, SERPINE1
19	periodontal disease	29.6	SERPINB2, MMP1, MMP9, FN1, IL11, IL16
20	sepsis	29.3	SELE, SELL, SELP, SERPINC1, SERPINA6, SERPINB2
21	thromboembolism	29.3	VWF, SELP, SERPINC1, SERPINE1, MTHFR, ITGA2
22	twinning	29.2	REN, VWF, SERPINC1, SERPINE1, VEGFA, LPL
23	pulmonary hypertension	29.2	SETD2, UTS2, FLT1, FGA, DDAH2, NOS2
24	insulin resistance	29.0	REN, CNR1, KISS1, VWF, SELE, SELL
25	antithrombin iii deficiency	29.0	SERPINC1, MTHFR, FGA, APOH, F5, F2
26	malignant hypertension	28.9	REN, VWF, APOH, CYP1A1, EDN1, ACE
27	aldosteronism	28.8	REN, KISS1, SERPINA6, SERPINE1, NAMPT, VEGFA
28	neural tube defect	28.8	VANGL2, MTHFR, CGA, CGB, CGB5, CGB7
29	renovascular hypertension	28.6	REN, SERPINC1, INS, ALB, CAT, HMOX1
30	periodontitis	28.5	MPO, MMP1, MMP9, IL10, IL16, IL17A
31	chorioamnionitis	28.4	SERPINC1, CGB5, MPO, CD163, MMP1, MMP9
32	hyperuricemia	28.3	REN, SELP, SERPINE1, LPL, UMOD, LEP
33	down syndrome	28.2	CNR1, KISS1, SERPINC1, SERPINE1, VEGFA, PARP1
34	obesity	27.9	REN, CNR1, KISS1, KIR3DL1, VWF, SELE
35	protein s deficiency	27.6	SERPINC1, SERPINE1, MTHFR, FGA, IL2, APOE
36	type 1 diabetes mellitus	27.4	KIR3DL1, LEP, LEPR, B2M, INS, IL15
37	breast cancer	27.3	VEGFA, KDR, MTHFR, XRCC1, MMP1, MMP9
38	high blood pressure	27.3	REN, LPL, LEP, INS, ALB, NOS3
39	systemic lupus erythematosus	27.1	VWF, SELE, VCAM1, LCN2, MPO, CD28
40	morbid obesity	27.1	REN, CNR1, SELE, SELL, SERPINE1, NAMPT
41	t-cell leukemia	27.1	CD28, CD40, IL16, IL1A, IL2, IL5
42	homocysteine	27.0	REN, VWF, SELE, SELP, SERPINC1, SETD2
43	vaginitis	26.9	SELE, SERPINC1, SERPINA6, SERPINE1, LIF, BGN
44	thyroiditis	26.7	PIGF, REN, KISS1, VWF, SELE, SELP
45	thrombocytopenia	26.6	VWF, SELE, SELL, SELP, SERPINC1, SERPINE1
46	coronary heart disease	26.3	VWF, SELE, SELL, SELP, SERPINC1, SERPINA6
47	diabetes mellitus	25.9	REN, CNR1, KIR3DL1, VWF, SELE, SELL
48	leukemia	25.8	REN, CNR1, KIR3DL2, KIR2DL4, KIR3DL1, VWF
49	glomerulonephritis	25.7	REN, VWF, SELP, SERPINC1, SERPINE1, VEGFA
50	ischemia	25.4	PIGF, REN, CNR1, VWF, SELE, SELL

Clinical features from OMIM: 189800

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 [cv490] antihypertensives,other, acebutolol, acebutolol hydrochloride, amiloride, amiloride hydrochloride, amlodipine, amlodipine besylate, atenolol, benazepril, benazepril hydrochloride, bendroflumethiazide, benzthiazide, bepridil, bepridil hydrochloride, betaxolol, betaxolol hydrochloride, bisoprolol, bisoprolol fumarate, bumetanide, candesartan, candesartan cilexetil, carteolol, carteolol hydrochloride, carvedilol, carvedilol phosphate, chlorothiazide, chlorothiazide sodium, chlorthalidone, clonidine, clonidine hcl pwdr [va product], clonidine hydrochloride, coenzyme q10, cyclothiazide, deserpidine, diltiazem, diltiazem hcl, diltiazem hydrochloride, diltiazem maleate, ditiaz, dong quai, doxazosin, doxazosin mesylate, eplerenone, eprosartan, eprosartan mesylate, esmolol, esmolol hydrochloride, ethacrynate sodium, ethacrynic acid, felodipine, fish oil, fosinopril, fosinopril sodium, furosemide, garlic oil, guanabenz, guanabenz acetate, guanadrel, guanadrel sulfate, guanethidine, guanethidine monosulfate, guanfacine, guanfacine hydrochloride, hydrochlorothiazide, hydroflumethiazide, indapamide, irbesartan, isradipine, lisinopril, losartan, losartan potassium, magnesium sulfate, methyclothiazide, methyldopa, methyldopate hydrochloride, metolazone, metoprolol, metoprolol succinate, metoprolol tartrate, mibefradil, mibefradil dihydrochloride, moexipril, moexipril hydrochloride, nadolol, nicardipine, nicardipine hydrochloride, nifedipine, nisoldipine, olmesartan, olmesartan medoxomil, penbutolol, penbutolol sulfate, perindopril, perindopril erbumine, pindolol, polythiazide, prazosin, prazosin hydrochloride, propranolol, propranolol hydrochloride, quinapril, quinapril hydrochloride, quinethazone, ramipril, reserpine, spironolactone, spironolactone pwdr [va product], telmisartan, terazosin, terazosin hydrochloride, timolol, timolol hemihydrate, timolol maleate, torsemide, trandolapril, triamterene, trichlormethiazide, valsartan, verapamil, verapamil hydrochloride

MalaCards organs/tissues related to pre-eclampsia:

²²

MGI Mouse Phenotypes related to pre-eclampsia:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	11.5	SELL, SELP, LPL, VANGL2, LIF, SCNN1B
2	hematopoietic system phenotype	MP:0005397	11.4	SERPINB2, PAPPA2, LDHA, LCN2, FSHR, CD28
3	mortality/aging	MP:0010768	11.3	REN, CNR1, KISS1, VWF, GCM1, SELE
4	embryogenesis phenotype	MP:0005380	11.2	SERPINC1, SETD2, VANGL2, PARP1, XRCC1, INHBA
5	craniofacial phenotype	MP:0005382	11.1	VANGL2, FST, INHBA, INHBB, IL17A, NOV
6	immune system phenotype	MP:0005387	11.0	REN, VWF, SELL, SELP, SERPINA6, SERPINB2
7	nervous system phenotype	MP:0003631	10.4	REN, CNR1, KISS1, VWF, GCM1, SELP
8	limbs/digits/tail phenotype	MP:0005371	10.2	VEGFA, VCAN, VANGL2, BGN, LEP, MTHFR
9	endocrine/exocrine gland phenotype	MP:0005379	10.1	KISS1, SELL, XDH, FSHR, FSTL3, CD40LG
10	no phenotypic analysis	MP:0003012	9.8	CNR1, SERPINA6, VEGFA, VCAM1, LNPEP, VANGL2
11	liver/biliary system phenotype	MP:0005370	9.7	SERPINC1, SERPINA6, VEGFA, LPL, LIF, PAPPA2
12	skeleton phenotype	MP:0005390	9.4	CNR1, VEGFA, VCAN, VANGL2, LIF, BGN
13	other phenotype	MP:0005395	9.4	CNR1, KDR, LEPR, FSHR, CD40LG, ITGB3
14	normal phenotype	MP:0002873	9.3	REN, PCDH12, GCM1, SELE, VEGFA, VCAN
15	reproductive system phenotype	MP:0005389	8.9	REN, KISS1, VEGFA, VANGL2, LIF, BGN
16	behavior/neurological phenotype	MP:0005386	8.9	REN, CNR1, SELE, SELP, SERPINA6, LNPEP
17	adipose tissue phenotype	MP:0005375	8.2	CNR1, SERPINE1, LPL, LIF, UMOD, LEP
18	vision/eye phenotype	MP:0005391	7.4	SELE, SELP, SERPINC1, VEGFA, VANGL2, LIF
19	tumorigenesis	MP:0002006	7.3	SELL, SERPINE1, RASSF1, LEP, LEPR, LDHA
20	digestive/alimentary phenotype	MP:0005381	7.2	KISS1, VWF, VEGFA, VANGL2, LIF, SCNN1B
21	integument phenotype	MP:0010771	INF	CNR1, KISS1, SELP, LIF, BGN, PARP1
22	renal/urinary system phenotype	MP:0005367	INF	REN, KISS1, SELP, SERPINA6, VANGL2, SCNN1B
23	growth/size phenotype	MP:0005378	INF	REN, CNR1, KISS1, GCM1, SELE, SELP
24	muscle phenotype	MP:0005369	INF	REN, SERPINB2, VEGFA, LPL, LIF, BGN
25	cellular phenotype	MP:0005384	INF	CNR1, VWF, GCM1, SELE, SELL, SELP
26	homeostasis/metabolism phenotype	MP:0005376	INF	REN, CNR1, KISS1, VWF, SELE, SELL
27	cardiovascular system phenotype	MP:0005385	INF	REN, VWF, SELE, SELL, SELP, SERPINC1

Articles related to pre-eclampsia:

(show top 50)    (show all 496)

id	Title	Authors	Year	Affiliating Genes
1	Plasminogen activator inhibitor-1 gene polymorphisms in pre-eclampsia. (21370208)	D'Elia A.V.... Damante G.	2011	SERPINE1
2	Association of leptin level and leptin receptor gene polymorphisms with susceptibility to severe pre-eclampsia]. (21983736)	Guan L.X.... Jiang H.	2011	LEPR, LSL
3	Natriuretic peptide precursor B gene (TTTC)(n) micros atellite polymorphism in pre-eclampsia. (21514286)	SzabA^ G.... Nagy B.	2011	NPPB
4	Association between urotensin II gene polymorphism an d pre-eclampsia. (20653105)	Dikensoy E.... Balci S.O.	2010	UTS2
5	Polymorphisms of the angiotensin converting enzyme ge ne in early-onset and late-onset pre-eclampsia. (20044877)	Uma R.... Murphy D.J.	2010	ACE
6	Contribution of interferon-gamma receptor 1 gene poly morphisms to pre-eclampsia in China. (20070287)	Chen L.J.... Zou P.	2010	IFNGR1
7	Leptin gene (TTTC)(n) microsatellite polymorphism in pre-eclampsia and HELLP syndrome. (19634986)	Nagy B.... Rigo J.	2009	LEP
8	Adenosine deaminase activity in subjects with normal pregnancy, pregnancy induced hypertension and pre-eclampsia. (20306731)	Oladipo O.O.... Okorodudu A.O.	2009	ADA
9	GRP78 as a marker of pre-eclampsia: an exploratory st udy. (19482905)	LaverriA"re A.... Cohen M.	2009	HSPA5
10	Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia. (18703227)	Escudero C.... Sobrevia L.	2008	SLC29A1, ADORA2B, SLC29A2
11	Catalase activity, serum trace element and heavy metal concentrations, and vitamin A, D and E levels in pre-eclampsia. (19094444)	Kolusari A.... Yoruk I.H.	2008	CAT
12	Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes. (17167268)	Zusterzeel P.L.... Steegers E.A.	2007	GSTP1, CYP1A1, GSTT1
13	Lethal candida sepsis associated with myeloperoxidase deficiency and pre-eclampsia. (17614858)	Kalinski T.... Roessner A.	2007	MPO
14	Mannose-binding lectin (MBL) codon 54 gene polymorphism protects against development of pre-eclampsia, HELLP syndrome and pre-eclampsia-associated intrauterine growth restriction. (17314117)	Sziller I.... Witkin S.S.	2007	MBL2
15	The genetic predisposition to produce high levels of TGF-beta1 impacts on the severity of eclampsia/pre-eclampsia. (17653872)	Stanczuk G.A.... Sibanda E.N.	2007	TGFB1
16	Altered plasma neurokinin B levels in patients with pre-eclampsia. (17318561)	Geissbuehler V.... Eberhard J.	2007	TAC3
17	RCAS1 decidual immunoreactivity in severe pre-eclampsia: immune cell presence and activity. (17845206)	Wicherek L.... Kalinka J.	2007	EBAG9
18	First-trimester maternal serum PP-13, PAPP-A and second-trimester uterine artery Doppler pulsatility index as markers of pre-eclampsia. (17149788)	Spencer K.... Meiri H.	2007	PAPPA
19	Nitration of p38 MAPK in the placenta: association of nitration with reduced catalytic activity of p38 MAPK in pre-eclampsia. (16951426)	Webster R.P.... Myatt L.	2006	MAPK14
20	Increased global fibrinolytic capacity as a clue for activated fibrinolysis in pre-eclampsia. (16788310)	Sucak G.T.... Haznedar R.	2006	SERPINE1, F2
21	Prediction of pre-eclampsia by uterine artery Doppler ultrasonography and maternal serum pregnancy-associated plasma protein-A, free beta-human chorionic gonadotropin, activin A and inhibin A at 22 + 0 to 24 + 6 weeks' gestation. (16493628)	Spencer K.... Nicolaides K.H.	2006	PAPPA, CGB
22	Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia. (16870954)	Laivuori H.... Powers R.W.	2006	LPL, LEP, CPT1A
23	Pre-eclampsia-associated alterations in Wharton's jelly proteoglycans. (15912205)	Gogiel T.... Jaworski S.	2005	DCN
24	A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia. (15775999)	Soleymanlou N.... Caniggia I.	2005	BOK
25	The effect of pre-eclampsia on the levels of coagulat ion and fibrinolysis factors in umbilical cord blood of newborns. (15795535)	Zanardo V.... Simioni P.	2005	F5
26	Association between HLA-G genotype and risk of pre-eclampsia: a case-control study using family triads. (14985477)	Hylenius S.... Hviid T.V.	2004	HLA-G
27	Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency. (15552268)	Herrmann W.... Geisel J.	2004	CST3
28	Altered cell kinetics in cultured placental villous e xplants in pregnancies complicated by pre-eclampsia and intrauterine growth res triction. (15307133)	Crocker I.P.... Baker P.N.	2004	CGA
29	Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. (15280126)	Williams M.A.... Bazul V.	2004	MTHFR
30	Placentology in the world's most livable city: HLA-G, pre-eclampsia and HIF-1. (12659462)	Yong P.J.	2003	HLA-G, SETD2
31	Placental GPI-PLD is of maternal origin and its GPI substrate is absent from placentae of pregnancies associated with pre-eclampsia. (12896829)	Deborde S.... Rademacher T.W.	2003	GPLD1
32	Association of Leiden mutation in factor V gene with hypertension in pregnancy and pre-eclampsia: a meta-analysis. (12817161)	Kosmas I.P.... Ioannidis J.P.	2003	F5
33	Plasminogen activator inhibitor type 1 (PAI1) and platelet glycoprotein IIIa (PGIIIa) polymorphisms in Black South Africans with pre-eclampsia. (12716314)	Pegoraro R.J.... Moodley J.	2003	SERPINE1, ITGB3
34	The relationship between insulin and insulin-like growth factor binding protein-1 is modified by pre-eclampsia. (14992166)	Anim-Nyame N.... Johnson M.J.	2003	IGFBP1
35	The regional expression of insulin-like growth factor II (IGF-II) and insulin-like growth factor binding protein-1 (IGFBP-1) in the placentae of women with pre-eclampsia. (11969341)	Gratton R.J.... Han V.K.	2002	IGF2, IGFBP1
36	The C242T-polymorphism of the NADPH/NADH oxidase gene p22phox subunit is not associated with pre-eclampsia. (12037698)	Raijmakers M.T.... Peters W.H.	2002	NQO1
37	The HELPP syndrome--evidence of a possible systemic inflammatory response in pre-eclampsia? (12221908)	Balderas-PeA+a L.M.... GonzA!lez Ojeda A.	2002	SLC17A5
38	Leptin, leptin resistance and endothelial dysfunction in pre-eclampsia. (12643450)	Anderson C.M.... Ren J.	2002	LEP, LSL
39	Elevated C-reactive protein and pro-inflammatory cyto kines in Andean women with pre-eclampsia. (11728484)	Teran E.... Lopez-Jaramillo P.	2001	IL6
40	Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in pre-eclampsia. (11170825)	Wang Y.... Walsh S.W.	2001	SOD1
41	Genetic analysis of insulin-like growth factor II and HLA-G in pre-eclampsia. (10816131)	Bermingham J.... O'Brien M.	2000	HLA-G
42	Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. (10866201)	Page N.M.... Lowry P.J.	2000	TACR3, TAC3
43	Urinary albumin excretion and 24-hour blood pressure as predictors of pre-eclampsia in Type I diabetes. (10952467)	Ekbom P.... Mathiesen E.R.	2000	ALB
44	Serum leptin concentration in cord blood: relationship to birth weight and gender in pregnancies complicated by pre-eclampsia. (11228066)	Laml T.... Wagenbichler P.	2000	LEP, LSL
45	Peripartal temporal course of endothelin 1, angiotensin II, and atrial natriuretic peptide in pre-eclampsia and normotensive pregnancy. (9813426)	Zunker P.... Ringelstein E.B.	1998	AGT, EDN1, NPPA
46	Circulating vascular cell adhesion molecule-1 in pre-eclampsia, gestational hypertension, and normal pregnancy: evidence of selective dysregulation of vascular cell adhesion molecule-1 homeostasis in pre-eclampsia. (9731854)	Higgins J.R.... Walshe J.J.	1998	SELE
47	The responsiveness of isolated human hand vein endothelial cells in normal pregnancy and in pre-eclampsia. (9508821)	Mahdy Z.... Gillespie J.I.	1998	KNG1
48	Association of circulating endothelium and noradrenaline with increased calcium-channel binding sites in the placental bed in pre-eclampsia. (9800935)	Ferreira-de-Almeida J.A.... PolA^nia J.J.	1998	EDN1
49	Muscarinic cholinergic receptors and acetylcholinesterase activity in umbilical artery and vein in pregnancy-induced hypertension (pre-eclampsia). (9385471)	Tayebati S.K.... Amenta F.	1997	ACHE
50	Increased immunohistochemical expression of neutral metalloendopeptidase (enkephalinase; EC 3.4.24.11) in villi of the human placenta with pre-eclampsia. (7479614)	Li X.M.... Forest J.C.	1995	MME

Genes related to pre-eclampsia according to GeneCards:

(show top 50)    (show all 319)

id	Symbol	Description	Score	GeneCards Section Context
1	PIH	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	11.1	Aliases & Descriptions, Publications
2	TAC3	tachykinin 3	11.1	Publications, Summaries
3	STOX1	storkhead box 1	11.1	Publications, Summaries
4	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.1	Summaries, Publications
5	IGFBP1	insulin-like growth factor binding protein 1	11.1	Publications
6	VCAM1	vascular cell adhesion molecule 1	11.1	Publications
7	SOD1	superoxide dismutase 1, soluble	11.0	Publications
8	PGF	placental growth factor	11.0	Publications
9	HLA-G	major histocompatibility complex, class I, G	11.0	Publications
10	LSL	Leptin, serum levels of	11.0	Publications
11	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
12	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
13	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
14	LEP	leptin	11.0	Publications
15	GSTP1	glutathione S-transferase pi 1	11.0	Publications
16	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
17	MAOA	monoamine oxidase A	11.0
18	VASH1	vasohibin 1	11.0	Publications
19	EBAG9	estrogen receptor binding site associated, antigen, 9	11.0	Publications
20	EGLN2	egl nine homolog 2 (C. elegans)	11.0	Publications
21	SIGLEC6	sialic acid binding Ig-like lectin 6	11.0
22	LCN1	lipocalin 1	11.0	Publications
23	EGLN3	egl nine homolog 3 (C. elegans)	11.0	Publications
24	HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	11.0	Publications
25	FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	11.0	Publications
26	HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	11.0	Publications
27	KNG1	kininogen 1	11.0	Publications
28	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
29	LEPR	leptin receptor	11.0	Publications
30	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
31	FN1	fibronectin 1	11.0	Publications
32	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
33	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
34	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
35	XDH	xanthine dehydrogenase	11.0	Publications
36	VEGFA	vascular endothelial growth factor A	11.0	Publications
37	TNF	tumor necrosis factor	11.0	Publications
38	IL1B	interleukin 1, beta	11.0	Publications
39	ALB	albumin	11.0	Publications
40	CRP	C-reactive protein, pentraxin-related	11.0	Publications
41	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
42	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
43	ST2	suppression of tumorigenicity 2	11.0	Publications
44	PEE1	preeclampsia/eclampsia 1	11.0	Publications
45	LGALS13	lectin, galactoside-binding, soluble, 13	11.0	Publications
46	NM	neutrophil migration	11.0	Publications
47	C19orf33	chromosome 19 open reading frame 33	11.0	Publications
48	ENG	endoglin	11.0	Publications
49	GCM1	glial cells missing homolog 1 (Drosophila)	11.0	Publications
50	INHBE	inhibin, beta E	11.0

Pathways related to pre-eclampsia according to GeneDecks:

(show top 50)    (show all 118)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	11.3	SELL, SELP, VCAN, CD28, CD34, CD40
2	Antigen processing and presentation20	11.1	KIR3DL2, KIR2DL4, KIR3DL1, HSPA5, HSPA4, HSPA8
3	Blood Coagulation Signaling Pathways37	11.1	VWF, SERPINC1, SERPINB2, SERPINE1, GP5, F8
4	Glioma Invasiveness36	11.0	UTS2, CD44, ITGA1, ITGAM, ITGB2, HMMR
5	Complement and coagulation cascades20	10.9	VWF, SERPINC1, SERPINE1, FGA, MBL2, F8
6	Immune System38	10.6	KIR3DL2, KIR2DL4, KIR3DL1, VCAM1, LNPEP, S100B
7	Hematopoietic cell lineage20	10.3	CD34, CD44, ITGA1, ITGA2, ITGAM, ITGB3
8	RAR-Gamma-RXR-Alpha Degradation36	10.3	LIF, IL11, IL15, IL16, IL2, MAPK14
9	Graft-versus-host disease20	10.2	KIR3DL2, KIR3DL1, CD28, IL1A, IL2, FASLG
10	Intestinal immune network for IgA production20	10.2	CD28, CD40LG, CD40, IL10, IL15, IL2
11	Akt Signaling36	10.2	UTS2, LIF, CD28, ITGA1, ITGA2, ITGAM
12	PPAR Pathway36	10.0	UTS2, ITGA1, ITGA2, ITGAM, ITGB2, ITGB3
13	THC Differentiation Pathway36	9.9	CD28, IL10, IL18, IL2, IL4, IL4R
14	IL-6 Pathway36	9.9	IL10, IL11, IL16, IL18, IL4, IL5
15	PGC1Alpha Pathway36	9.9	IL11, IL13, IL15, IL16, IL18, IL1A
16	Autoimmune thyroid disease20	9.9	CGA, CD28, CD40LG, CD40, IL10, IL2
17	Endothelin-1 Signaling Pathway36	9.8	FLT1, IL10, IL11, IL13, IL16, IL18
18	Phagosome20	9.7	MPO, ITGA2, ITGAM, ITGB2, ITGB3, MBL2
19	PEDF Induced Signaling36	9.5	LIF, IL10, IL11, IL13, IL15, IL16
20	MIF Mediated Glucocorticoid Regulation36	9.5	LIF, MIF, IL10, IL11, IL13, IL15
21	MIF Regulation of Innate Immune Cells36	9.5	LIF, MIF, IL10, IL11, IL13, IL15
22	all-trans-Retinoic Acid Signaling in Brain36	9.5	LIF, IL10, IL11, IL13, IL15, IL16
23	NFAT Signaling and Lymphocyte Interactions36	9.5	IL11, IL13, IL15, IL16, IL1A, IL2
24	Leishmaniasis20	9.5	ITGAM, ITGB2, IL10, IL1A, IL1B, IL4
25	STAT3 Pathway36	9.4	LIF, CD28, IL10, IL11, IL13, IL15
26	Angiogenesis3	9.4	REN, KDR, ITGB3, MMP9, FLT1, ENG
27	Regulation of eIF4 and p70S6K36	9.4	ITGA1, ITGA2, ITGAM, ITGB2, ITGB3, IL11
28	ERK Signaling36	9.4	UTS2, ITGA1, ITGAM, ITGB2, FN1, FLT1
29	Influenza A20	9.3	IL18, IL1A, IL1B, IL33, IL6, IL8
30	Rheumatoid arthritis20	9.1	VEGFA, CD28, ITGB2, MMP1, FLT1, IL11
31	Allograft rejection20	9.0	CD28, CD40LG, CD40, IL10, IL2, IL4
32	Cytokine Network36	9.0	IL10, IL13, IL15, IL16, IL18, IL1A
33	MAPK Signaling36	8.8	UTS2, KDR, ITGA1, ITGA2, ITGAM, ITGB2
34	Type I diabetes mellitus20	8.7	CD28, INS, IL1A, IL1B, IL2, FASLG
35	Toxoplasmosis20	8.7	CD40LG, CD40, IL10, MAPK14, IFNG, IFNGR1
36	Malaria20	8.6	SELE, SELP, VCAM1, CD40LG, CD40, ITGB2
37	Glucocorticoid Receptor Signaling36	8.6	IL10, IL11, IL13, IL15, IL16, IL18
38	Molecular Mechanisms of Cancer36	8.6	UTS2, LIF, KDR, CDH1, ITGA1, ITGA2
39	Antioxidant Action of Vitamin-C36	8.5	UTS2, LIF, KDR, CD28, FLT1, IL10
40	MAPK Family Pathway36	8.4	UTS2, KDR, FLT1, IL10, IL11, IL13
41	Cytokine-cytokine receptor interaction20	8.3	VEGFA, LIF, KDR, LEP, LEPR, CD40LG
42	SOCS Pathway36	8.3	INS, IL10, IL11, IL13, IL15, IL16
43	PAK Pathway36	8.3	UTS2, LIF, KDR, FLT1, IL10, IL11
44	Rho Family GTPases36	8.2	UTS2, LIF, KDR, CDH1, ITGA1, ITGA2
45	Tec Kinases Signaling36	8.2	UTS2, CD28, ITGA1, ITGA2, ITGAM, ITGB2
46	Chagas disease (American trypanosomiasis)20	8.1	SERPINE1, IL10, IL1B, IL2, IL6, IL8
47	TGF-Beta Pathway36	8.0	UTS2, KDR, CDH1, FLT1, IL10, IL11
48	Pathways in cancer20	8.0	VEGFA, RASSF1, CDH1, ITGA2, MMP1, MMP9
49	p38 Signaling36	7.8	UTS2, LIF, KDR, CD28, FLT1, IL10
50	JAK-STAT Pathway36	7.6	UTS2, KDR, FLT1, IL10, IL11, IL13

Compounds related to pre-eclampsia according to GeneDecks:

(show top 50)    (show all 516)

id	Compound	Score	Top Affiliating Genes
1	forskolin32 42 9 9	14.7	REN, GCM1, LNPEP, LIF, S100B, CGA
2	heparin32 9 18 9	14.5	VWF, SERPINB2, SERPINE1, LPL, VCAN, LIF
3	thromboxane a232 18	12.4	VWF, SELP, LIF, CD63, ITGA2, FGA
4	cyclic amp32 18	12.3	CNR1, SETD2, SERPINB2, LIF, CGA, CGB
5	nitrate32	11.2	B2M, CGB5, FASLG, IDO1, TNFRSF1B, DDAH2
6	ptca32	11.1	SELP, ITGAM, ITGB2, FGA, APOH, CCL5
7	c-peptide32	11.0	LEP, IGF2, TNFRSF1B, PF4, SHBG, LSL
8	copper32 18	12.0	SERPINA6, LIF, S100B, ITGB2, APOH, AOC3
9	phenylephrine32 9 18 9	14.0	LPL, UTS2, LIF, LEP, CGA, CGB5
10	verapamil32 34 9 18 9	14.9	REN, UTS2, CGA, CDH1, GSTP1, GPT
11	acth32	10.9	REN, SERPINA6, LNPEP, LEP, LEPR, CGB5
12	gp 13032	10.9	LIF, LEPR, IL13, IL15, IL4R, IL6R
13	atp32	10.9	KIR3DL1, SETD2, LIF, PARP1, LDHA, CGB5
14	vitamin a32 9 18 9	13.9	VWF, SERPINA6, LPL, LEP, LCN1, LCN2
15	cholesterol32 9 18 9	13.6	REN, VWF, SELE, SELP, SERPINA6, SERPINE1
16	valsartan32 42 9 9	13.6	REN, SELP, SERPINE1, CCL2, ALB, CRP
17	arginine32	10.6	REN, CNR1, KIR2DL4, VWF, SERPINC1, SERPINA6
18	ascorbic acid32 18	11.5	SETD2, SERPINB2, LIF, XRCC1, S100B, CGA
19	nifedipine32 9 9	12.5	REN, SELE, SERPINE1, LEP, B2M, CGB5
20	carbohydrates32	10.5	SELE, SELL, SELP, SERPINA6, VCAM1, CLEC4A
21	perindopril32 34 9 9	13.4	REN, VWF, SERPINE1, VEGFA, ALB, CRP
22	fibrinogen32	10.4	SELE, SELP, SERPINC1, SERPINB2, SERPINE1, NAMPT
23	alanine32	10.4	CNR1, KISS1, VWF, SELE, SELL, SERPINC1
24	fenofibrate32 9 9	12.3	SELE, SELP, SERPINE1, LPL, VCAM1, LEP
25	norepinephrine32 9 18 9	13.3	REN, CNR1, VWF, SELE, SELL, SELP
26	epinephrine32 9 18 9	13.3	REN, SELE, SELL, SELP, LEP, CGA
27	phosphatidylcholine32	10.2	CNR1, SELE, LPL, VCAM1, ITGA2, FN1
28	polyacrylamide32	10.1	SERPINA6, VCAN, LEPR, LCN1, FSHR, FST
29	metformin32 34 9 9	13.1	CNR1, VWF, SERPINE1, NAMPT, LPL, LEP
30	pge232	9.8	REN, SELE, SETD2, SERPINB2, VCAM1, LNPEP
31	ramipril32 9 9	11.8	REN, SERPINE1, INS, ALB, CRP, ACE
32	infliximab32 9 9	11.8	SELE, VEGFA, MMP1, IL10, IL11, IL15
33	ibuprofen32 9 18 9	12.8	VCAM1, LEP, CGB5, MMP1, IL10, IL1B
34	bleomycin32 9 9	11.7	XRCC1, CGB, CGB7, CD44, GSTM1, GSTP1
35	glutamate32	9.6	CNR1, KDR, LEP, LEPR, MTHFR, CD40
36	rolipram32 42	10.5	SELE, SELL, ITGAM, ITGB2, IL10, IL13
37	gnrh32	9.4	SELL, SERPINE1, LEP, LEPR, CGB, CGB5
38	aspirin32 34 18	11.4	CNR1, VWF, SELE, SELL, SELP, SERPINC1
39	cysteine32	9.3	SELP, SERPINA6, UTS2, LIF, CLEC4A, PARP1
40	chloroquine32 34 9 9	12.3	SERPINC1, B2M, CDH1, ITGAM, IL10, IL15
41	taurine chloramine32	9.0	MPO, IL1B, IL2, IL6, IL8, IFNG
42	ribavirin32 34 9 9	11.9	LEP, CD40LG, MMP1, MMP9, IL10, IL18
43	rapamycin32 42	9.7	SELL, VEGFA, KDR, FN1, FLT1, AR
44	15-deoxy-delta-12,14-prostaglandin j232	8.6	SERPINE1, VEGFA, VCAM1, IL10, IL1B, IL4
45	cyclosporin a32 42	9.5	VWF, SELP, SERPINB2, LPL, LIF, LEP
46	4-hydroxynonenal32 18	9.2	PARP1, XDH, MPO, MME, MMP1, GSTM1
47	glutamine32	7.7	VWF, LPL, LEPR, XRCC1, S100B, B2M
48	cisplatin32 34 9 9	10.7	SETD2, VEGFA, LNPEP, RASSF1, LIF, PARP1
49	doxorubicin32 34 9 9	10.2	SELE, SETD2, VEGFA, PARP1, KDR, B2M
50	dexamethasone32 42 34 9 9	10.7	REN, VWF, SELL, SELP, SERPINC1, SERPINA6

Cellular components related to pre-eclampsia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.3	HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1, HLA-C, HLA-B
2	platelet alpha granule lumen	GO:031093	10.1	VEGFA, FN1, FGA, IGF1, F8, F5
3	ER to Golgi transport vesicle membrane	GO:012507	9.9	SREBF1, HLA-G, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPA1
4	external side of plasma membrane	GO:009897	9.9	HLA-DRB1, TNF, CTLA4, ACE, TLR2, TLR4
5	extracellular space	GO:005615	8.3	NGF, CXCL12, SOD1, SOD3, CSF1, CSF3
6	cell surface	GO:009986	INF	ITGA2, MIF, IL1A, APOH, AOC3, ENG
7	plasma membrane	GO:005886	INF	CNR1, KIR3DL2, KIR2DL4, KIR3DL1, PCDH12, PTGDR
8	extracellular region	GO:005576	INF	AMBP, PLAC1, PLAT, PLA2G2A, PLAU, NOV
9	integral to plasma membrane	GO:005887	INF	CD44, ITGB3, MME, FLT1, IL15, IL4R

Biological processes related to pre-eclampsia according to GeneDecks:

(show top 50)    (show all 56)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of apoptotic process	GO:043065	10.9	CNR1, MMP9, IL1B, FASLG, FAS, ANXA5
2	leukocyte migration	GO:050900	10.9	SELL, SELP, CD34, ITGAM, ITGB2, ITGB3
3	response to organic cyclic compound	GO:014070	10.8	SELP, IL1A, IL1RN, IL4, GPX3, F7
4	positive regulation of angiogenesis	GO:045766	10.8	SERPINE1, VEGFA, UTS2, KDR, CD34, MMP9
5	blood vessel remodeling	GO:001974	10.8	LIF, BGN, IGF1, NOS3, ACVR2B, ELN
6	response to lipopolysaccharide	GO:032496	10.8	CNR1, SELE, SELP, MMP9, IL13, IL1A
7	response to hypoxia	GO:001666	10.7	VEGFA, VCAM1, UTS2, SCNN1B, LEP, XRCC1
8	cell adhesion	GO:007155	10.7	VWF, SELL, SELP, VCAM1, VCAN, CLEC4A
9	cell-cell signaling	GO:007267	10.7	NAMPT, LNPEP, CGA, CGB, AVP, ITGB2
10	positive regulation of protein phosphorylation	GO:001934	10.6	VEGFA, CD40, ITGB3, IL1B, ENG, IGF2
11	positive regulation of inflammatory response	GO:050729	10.5	SERPINE1, IL15, IL18, IL2, IL33, CCL3
12	positive regulation of vasodilation	GO:045909	10.5	UTS2, INS, HMOX1, NOS3, AGTR2, NPPC
13	platelet degranulation	GO:002576	10.5	VWF, SELP, SERPINE1, VEGFA, CD63, ITGB3
14	positive regulation of chemokine production	GO:032722	10.5	IL18, IL6, IL6R, TNF, HIF1A, TLR2
15	negative regulation of platelet activation	GO:010544	10.4	APOE, GP5, F2, NOS3, PDGFA, PDGFRA
16	positive regulation of cell division	GO:051781	10.4	VEGFA, IL1A, IL1B, IGF2, CAT, PPBP
17	platelet activation	GO:030168	10.3	VWF, SELP, SERPINE1, VEGFA, CD40LG, CD63
18	blood coagulation	GO:007596	10.3	VWF, SELL, SELP, SERPINC1, SERPINB2, SERPINE1
19	aging	GO:007568	10.3	CNR1, VCAM1, IL15, IL1B, FAS, CCL2
20	positive regulation of smooth muscle cell proliferation	GO:048661	10.3	FLT1, IL13, IL6, IL6R, CCL5, IGF1
21	response to ethanol	GO:045471	10.3	CNR1, AVP, MMP9, IL13, IL4, CCL2
22	response to glucocorticoid stimulus	GO:051384	10.3	SERPINE1, IL10, IL1B, IL1RN, IL6, FAS
23	regulation of immune response	GO:050776	10.3	KIR3DL2, KIR2DL4, KIR3DL1, SELL, VCAM1, B2M
24	signal transduction	GO:007165	10.1	KIR2DL4, NAMPT, CGA, CGB, AVP, FST
25	acute-phase response	GO:006953	10.0	CD163, FN1, INS, IL1RN, IL6, IL6R
26	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.0	SELP, KDR, FLT1, INS, FGR, CCL5
27	inflammatory response	GO:006954	9.9	SELE, SELP, CD40LG, CD40, ITGB2, MIF
28	interferon-gamma-mediated signaling pathway	GO:060333	9.9	VCAM1, B2M, CD44, IFNG, IFNGR1, ICAM1
29	negative regulation of apoptotic process	GO:043066	9.9	SERPINE1, VEGFA, KDR, LEP, AVP, CD44
30	positive regulation of cell migration	GO:030335	9.9	VEGFA, KDR, CGA, FLT1, INS, FGR
31	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.9	VEGFA, LIF, CD44, ITGB3, MIF, INS
32	angiogenesis	GO:001525	9.8	SETD2, SERPINE1, VEGFA, VASH1, KDR, FN1
33	positive regulation of MAPK cascade	GO:043410	9.8	LIF, KDR, LEP, FLT1, AR, INS
34	negative regulation of smooth muscle cell proliferation	GO:048662	9.7	IL15, IGFBP3, IFNG, HMOX1, PTGIR, NOS3
35	lipopolysaccharide-mediated signaling pathway	GO:031663	9.7	IL18, IL1B, MAPK14, CCL2, CCL3, CCL5
36	positive regulation of nitric oxide biosynthetic process	GO:045429	9.7	INS, IL1B, IFNG, ICAM1, TNF, DDAH1
37	immune response	GO:006955	9.6	KIR3DL1, LIF, IL13, IL15, IL16, IL17A
38	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.5	CD40, AR, INS, IL1B, IL6, IL6R
39	positive regulation of mitosis	GO:045840	9.5	CD28, INS, IL1A, IL1B, IGF2, IGF1
40	cellular response to interleukin-1	GO:071347	9.5	MMP9, IL17A, IL8, CCL2, CCL3, CCL5
41	anti-apoptosis	GO:006916	9.3	SERPINB2, MPO, CD40LG, GSTP1, IL10, IL1A
42	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.1	SERPINE1, VEGFA, LIF, CGA, FSTL3, CD40
43	cytokine-mediated signaling pathway	GO:019221	9.1	VCAM1, B2M, CD44, IL1A, IL1B, IL5
44	cell surface receptor signaling pathway	GO:007166	9.1	CLEC4A, LEPR, CD28, MIF, INHA, INHBA
45	cellular response to lipopolysaccharide	GO:071222	9.0	SERPINE1, GSTP1, IL10, IL8, CCL2, IFNG
46	positive regulation of protein kinase B signaling cascade	GO:051897	8.9	INS, CCL3, IGF2, IGF1, F7, F3
47	response to drug	GO:042493	8.7	REN, LPL, UTS2, XRCC1, B2M, CDH1
48	positive regulation of cell proliferation	GO:008284	8.6	NAMPT, VEGFA, LIF, KDR, LEP, CGA
49	regulation of blood pressure	GO:008217	INF	REN, UTS2, LEP, CD34, HMOX1, NOS3
50	female pregnancy	GO:007565	INF	LNPEP, PAPPA, LEP, FLT1, IL1RN, IL4

Molecular functions related to pre-eclampsia according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	activin binding	GO:048185	11.0	TGFBR3, ACVR1, ACVR1B, ACVR2A, ACVR2B, ENG
2	protein homodimerization activity	GO:042803	10.8	ACHE, SHBG, PDGFRA, PDGFA, NOS2, CRP
3	hormone activity	GO:005179	10.8	ADIPOQ, UTS2, LEP, CGA, ADM, NPPC
4	heparin binding	GO:008201	10.6	CYR61, PF4, HBEGF, THBS2, TGFBR3, SOD3
5	collagen binding	GO:005518	10.4	DCN, DPP4, ACHE, PDGFA, GP5, FN1
6	eukaryotic cell surface binding	GO:043499	10.3	ADIPOQ, TGFB1, HBEGF, PDGFA, ANXA5, MBL2
7	receptor binding	GO:005102	10.1	CRH, HLA-G, HLA-B, HLA-A, CAT, HSPA8
8	chemokine activity	GO:008009	9.9	CXCL11, PF4, PPBP, CCL5, CCL3, CCL1
9	protease binding	GO:002020	9.8	CST3, DPP4, TNFRSF1A, TNF, F3, INS
10	cytokine activity	GO:005125	9.6	ADIPOQ, CSF3, CSF1, EDN1, TNF, IFNG
11	growth factor activity	GO:008083	9.5	INHBC, INHBB, INHBA, INHA, LEP, LIF
12	protein binding	GO:005515	8.1	HSPA5, APOE, APEX1, IL8, IL6ST, IL6R