MCID: PRC016
MIFTS: 64

Pre-Eclampsia malady

Reproductive category

Summaries for Pre-Eclampsia

Sources:
21Genetics Home Reference, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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Genetics Home Reference:21 Preeclampsia is a complication of pregnancy in which affected women develop high blood pressure (hypertension) and can also have abnormally high levels of protein in their urine. This condition usually occurs in the last few months of pregnancy and often requires the early delivery of the infant.

MalaCards: Pre-Eclampsia, also known as preeclampsia, is related to eclampsia and hellp syndrome. An important gene associated with Pre-Eclampsia is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are HIF-1 signaling pathway and HIF-1-alpha transcription factor network. The drug magnesium sulfate and the compounds vegf and creatinine have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:64 Pre-eclampsia or preeclampsia is a medical condition characterized by high blood pressure and... more...

Description from OMIM:47 189800,609404,609402,609403,614595

Aliases & Classifications for Pre-Eclampsia

Sources:
8Disease Ontology, 9diseasecard, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive


Characteristics (Orphanet epidemiological data):

49
preeclampsia:
Prevalence: 1-5/10000


Aliases & Descriptions:

pre-eclampsia 8 21 10 61
preeclampsia 8 21 47 45 49
hypertension induced by pregnancy 8 61
pregnancy-induced hypertension 8 21
toxemia of pregnancy 8 21
proteinuric hypertension of pregnancy 8
gestational proteinuric hypertension 21
pregnancy associated hypertension 8
preeclampsia, susceptibility to 9
hypertension, pregnancy-induced 47
hypertension of pregnancy nos 8
gestational hypertension 8
preeclampsia/eclampsia 8
pre-eclamptic toxaemia 8
toxaemia of pregnancy 8
hypertension of preg. 8
pregnancy toxemias 45
pre-eclamptic nos 8
pregnancy toxemia 8
pre-eclampsia nos 8
toxaemia nos 8
toxemia nos 8


Related Diseases for Pre-Eclampsia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pre-Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 271)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia32.4HLA-G, SERPINC1
2hellp syndrome31.2APOH, F5, SERPINE1, SERPINC1, GSTP1
3mild pre-eclampsia30.9SOD1, IGFBP1, VCAM1
4thrombophilia30.7APOH, F5, SERPINE1, SERPINC1
5placental insufficiency30.7FLT1, IGFBP1
6placental abruption30.7SERPINC1, F5
7insulin resistance30.6AGT, IGFBP1, LEP, NOS3, VCAM1, SERPINE1
8chorioamnionitis30.5FLT1
9pregnancy loss30.5SERPINC1, F5, HLA-G, APOH
10down syndrome30.4SOD1
11antiphospholipid syndrome30.3APOH, F5, VCAM1, SERPINC1
12sepsis30.3F5, NOS3, SERPINE1, SERPINC1
13thrombocytopenia30.3APOH, F5, SERPINC1
14bronchopulmonary dysplasia30.3FLT1, SOD1
15vascular disease30.1SOD1, APOH, F5, AGT, NOS3, VCAM1
16thromboembolism30.1SERPINC1, SERPINE1, NOS3, F5, APOH
17polycystic ovary syndrome30.1IGFBP1, LEP, SERPINE1
18alzheimer's disease30.1GSTP1, NOS3, MAOA, SOD1
19hyperinsulinism30.1IGFBP1, LEP, SERPINE1
20vasculitis30.1VCAM1, APOH
21nephritis30.1VCAM1, APOH
22central retinal vein occlusion30.1F5, APOH
23lupus nephritis30.1APOH, VCAM1
24portal vein thrombosis30.1F5, SERPINC1
25acute pancreatitis30.1SOD1
26glucose intolerance30.0SERPINE1, LEP, IGFBP1
27atherosclerosis29.8CORIN, SOD1, APOH, FLT1, AGT, LEP
28hyperhomocysteinemia29.8SOD1, APOH, F5, NOS3, VCAM1, SERPINE1
29adenoma29.8HLA-G, FLT1, IGFBP1, EPHX1, GSTP1
30protein c deficiency29.8SERPINC1, SERPINE1, F5, APOH
31infertility29.8HLA-G, IGFBP1, LEP
32protein s deficiency29.8APOH, F5, SERPINE1, SERPINC1
33thrombophlebitis29.8APOH
34gestational diabetes10.6
35hypoxia10.6
36blindness10.5
37n syndrome10.4
38preeclampsia/eclampsia 210.4
39preeclampsia/eclampsia 110.4
40preeclampsia/eclampsia 310.4
41preeclampsia/eclampsia 410.4
42peripartum cardiomyopathy10.4
43cortical blindness10.4
44preeclampsia/eclampsia 510.3
45triploidy10.3
46anuria10.3
47beckwith-wiedemann syndrome10.3
48intrahepatic cholestasis10.2
49micro syndrome10.2
50chorioangioma10.2

Graphical network of the top 20 diseases related to Pre-Eclampsia:



Diseases related to pre-eclampsia

Clinical Features for Pre-Eclampsia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

189800,609404,609402,609403,614595

Clinical synopsis from OMIM:

189800

Drugs & Therapeutics for Pre-Eclampsia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Pre-Eclampsia

Drug clinical trials:

Search ClinicalTrials for Pre-Eclampsia

Search NIH Clinical Center for Pre-Eclampsia

Search CenterWatch for Pre-Eclampsia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Pre-Eclampsia

Anatomical Context for Pre-Eclampsia

Animal Models for Pre-Eclampsia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Pre-Eclampsia

Sources:
51PubMed
See all sources

Articles related to Pre-Eclampsia:

(show top 50)    (show all 446)
idTitleAuthorsYear
1
Angiogenic factors combined with clinical risk factors to predict preterm pre-eclampsia in nulliparous women: a predictive test accuracy study. (23906160)
2013
2
Performance of the fullPIERS model in predicting adverse maternal outcomes in pre-eclampsia using patient data from the PIERS (Pre-eclampsia Integrated Estimate of RiSk) cohort, collected on admission. (23078362)
2013
3
Serum trace elements levels in preeclampsia and eclampsia: correlation with the pregnancy disorder. (23526144)
2013
4
Presence of auto-antibody against two placental proteins, annexin A1 and vitamin D binding protein, in sera of women with pre-eclampsia. (23830177)
2013
5
Phase I pilot clinical trial of antenatal maternally administered melatonin to decrease the level of oxidative stress in human pregnancies affected by pre-eclampsia (PAMPR): study protocol. (24056493)
2013
6
The incidence of preeclampsia and eclampsia and associated maternal mortality in Australia from population-linked datasets: 2000-2008. (23467048)
2013
7
Pre-eclampsia-An additional risk factor for cognitive impairment at school age after intrauterine growth restriction and very preterm birth. (24388669)
2013
8
Increased inflammatory biomarkers in early pregnancy is associated with the development of pre-eclampsia in patients with periodontitis: a case control study. (23035752)
2013
9
Pica causing neurocysticercosis in pregnancy presenting as eclampsia: a report of two cases. (24431605)
2013
10
Biomarkers for the management of pre-eclampsia in pregnant women. (24056556)
2013
11
Evaluation of the diagnostic value of the first-trimester maternal serum high-sensitivity C-reactive protein level for prediction of pre-eclampsia. (23875844)
2013
12
Pregnancy outcome in early-onset severe pre-eclampsia in Trinidad. (22036510)
2012
13
LEPR c.668A>G polymorphism in a cohort of Sri Lankan women with pre-eclampsia / pregnancy induced hypertension: a case control study. (22713493)
2012
14
Reduced soluble receptor for advanced glycation end-products (sRAGE) scavenger capacity precedes pre-eclampsia in Type 1 diabetes. (22900949)
2012
15
Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia: a systematic review and meta-analysis. (22433027)
2012
16
Secular trends in the epidemiology of pre-eclampsia throughout 40 years in Norway: prevalence, risk factors and perinatal survival. (22471678)
2012
17
Neonatal outcomes of late preterm deliveries with pre-eclampsia. (22481621)
2012
18
Clinical risk prediction of pre-eclampsia. (21474516)
2011
19
Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. (21596735)
2011
20
Does preeclampsia/eclampsia pose a higher disease burden to mothers in pastoralist communities in Ethiopia? (21796917)
2011
21
Is there a direct effect of pre-eclampsia on cerebral palsy not through preterm birth? (21281323)
2011
22
Delayed postpartum preeclampsia and eclampsia: demographics, clinical course, and complications. (21979459)
2011
23
Serum lipids level assessed in early pregnancy and risk of pre-eclampsia. (21676073)
2011
24
Apoptosis, proliferation and Fas ligand expression in placental trophoblast from pregnancies complicated by HELLP syndrome or pre-eclampsia. (21501125)
2011
25
Vasohibin and VEGF protein levels in placentae from pregnancies complicated by severe pre-eclampsia]. (21302448)
2010
26
Risk factors of adverse pregnancy outcomes during expectant management of early onset severe pre-eclampsia]. (20450750)
2010
27
Proteome differences of placenta between pre-eclampsia and normal pregnancy. (19954843)
2010
28
First-trimester maternal serum pregnancy-associated plasma protein-A and pre-eclampsia. (19090499)
2009
29
First trimester serum PAPP-A and NGAL in the prediction of late-onset pre-eclampsia. (19626600)
2009
30
Predictors and risk factors of pre-eclampsia. (18854808)
2008
31
The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell-free DNA and mRNA in normal pregnancy and pre-eclampsia. (18834630)
2008
32
Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome. (18791734)
2008
33
Expression of relaxin receptor in placental tissues of normal pregnancy and pre-eclampsia]. (18843967)
2008
34
The human tumor-associated antigen RCAS1 in pregnancies complicated by pre-eclampsia. (17604121)
2008
35
Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia. (16870954)
2006
36
Precursors to pre-eclampsia: are there markers in the fetal circulation? (14989695)
2004
37
Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre-eclampsia. (12460234)
2002
38
Adhesion molecules expression in the placental bed of pregnancies with pre-eclampsia. (11888102)
2002
39
Significance of changes in lipid peroxides and antioxidant enzyme activities in pregnant women with preeclampsia and eclampsia. (10968357)
2000
40
Muscarinic cholinergic receptors and acetylcholinesterase activity in umbilical artery and vein in pregnancy-induced hypertension (pre-eclampsia). (9385471)
1997
41
Systemic and fetal-maternal nitric oxide synthesis in normal pregnancy and pre-eclampsia. (8813307)
1996
42
Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia. (8848592)
1995
43
Secretion of endothelin-1 by trophoblast cells and binding of endothelin-1 to trophoblast membranes in healthy and pre-eclampsia pregnancies]. (8672925)
1995
44
The relationship between urinary Tamm-Horsfall glycoprotein excretion and urinary activity of glycosidases in normal pregnancy and pre-eclampsia. (8449258)
1993
45
The predictive value of total estriol; HPL and Hb on perinatal outcome in severe pre-eclampsia. (6516809)
1984
46
Serum seromucoid and the materno-paternal mixed leucocyte reaction following previous severe pre-eclampsia. (4266742)
1973
47
Serum proteins in normal pregnancy and mild pre-eclampsia. (4104344)
1971
48
The prevention of severe pre-eclampsia. (13770957)
1960
49
Prefrontal lobotomy and severe pre-eclampsia. (13498096)
1958
50
Retinal changes in the toxemias of pregnancy. I. History, vomiting of pregnancy, mild and severe pre-eclampsia, and eclampsia. (14885283)
1951

Genetic Variations for Pre-Eclampsia

Expression for genes affiliated with Pre-Eclampsia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pre-Eclampsia

Search GEO for disease gene expression data for Pre-Eclampsia.

Pathways for genes affiliated with Pre-Eclampsia

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 50PharmGKB
See all sources

Compounds for genes affiliated with Pre-Eclampsia

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1vegf4512.3APOH, AGT, F5, EGLN2, HLA-G, IGFBP1
2creatinine4512.1SERPINC1, F5, SOD1, APOH, HLA-G, FLT1
3arginine4512.1APOH, EPHX1, LEP, NOS3, F5, AGT
4prostacyclin4512.0SOD1, LEP, SERPINC1, SERPINE1, VCAM1, NOS3
5cholesterol45 29 11 2415.0IGFBP1, FLT1, APOH, HLA-G, F5, AGT
6nitric oxide45 11 2414.0SOD1, TAC3, IGFBP1, APOH, FLT1, AGT
7cysteine4511.8LEP, HLA-G, F5, SOD1, AGT, IGFBP1
8ascorbic acid45 2412.8EGLN2, LEP, SOD1, F5, MAOA, NOS3
9fibrinogen4511.8SERPINC1, VCAM1, LEP, AGT, IGFBP1, F5
10testosterone45 60 11 2414.7IGFBP1, MAOA, F5, LEP, VCAM1, GSTP1
11lipid4511.7IGFBP1, FLT1, HLA-G, APOH, AGT, SOD1
12homocysteine45 2412.7AGT, VCAM1, APOH, F5, NOS3, SERPINE1
13superoxide45 2412.7AGT, EPHX1, TAC3, NOS3, VCAM1, APOH
14phosphatidylinositol4511.6NOS3, LEP, EPHX1, IGFBP1, APOH, FLT1
15genistein45 29 60 2 11 2416.6VCAM1, NOS3, AGT, FLT1, IGFBP1, SERPINE1
168-isoprostane4511.6LEP, SOD1, APOH, VCAM1, NOS3, SERPINE1
17lactate4511.6SOD1, HLA-G, APOH, GSTP1, VCAM1, F5
18oxygen45 2412.6FLT1, AGT, IGFBP1, MAOA, EGLN2, HLA-G
19folate4511.5VCAM1, APOH, NOS3, F5, GSTP1, SERPINC1
20aspirin45 50 29 2414.5F5, APOH, NOS3, SERPINE1, SERPINC1, GSTP1
21methotrexate45 50 1113.5SERPINE1, GSTP1, APOH, NOS3, HLA-G, LEP
22epinephrine45 11 2413.4GSTP1, LEP, MAOA, IGFBP1, AGT, F5
23n(g)-nitro-l-arginine methyl ester4511.4AGT, LEP, NOS3, SERPINE1, SOD1
24p0034511.4EPHX1, SERPINE1, APOH, FLT1, HLA-G
25l-nmma4511.4NOS3, AGT, LEP, VCAM1, SOD1
26n acetylcysteine4511.4GSTP1, SERPINC1, VCAM1, LEP, AGT, SOD1
27progesterone45 60 29 11 2415.4IGFBP1, LEP, SERPINE1, F5, APOH, HLA-G
28sodium nitroprusside4511.3SERPINE1, VCAM1, NOS3, SOD1, LEP
29heparin45 29 11 2414.3APOH, FLT1, AGT, VCAM1
30atorvastatin45 50 29 11 2415.3NOS3, VCAM1, SERPINE1, AGT, F5
31cyclophosphamide45 50 1113.3NOS3, APOH, F5, GSTP1
32serine4511.3CORIN, FLT1, LEP, AGT
33p0024511.3APOH, FLT1, IGFBP1, LEP, F5
34tibolone4511.3SERPINE1, F5, LEP, SERPINC1
35apocynin45 6012.3VCAM1, AGT, SOD1, NOS3
36amlodipine45 50 11 2414.3AGT, NOS3, VCAM1, SERPINE1
37simvastatin45 50 60 29 11 2416.2F5, SERPINE1, VCAM1, NOS3, AGT
38tamoxifen45 50 29 1114.2EPHX1, VCAM1, IGFBP1
39uric acid45 2412.2APOH, F5, SERPINE1
40estrogen4511.1TAC3, APOH
41rosiglitazone45 50 29 11 2415.1IGFBP1, VCAM1, LEP
42ancrod4511.0F5, SERPINE1, SERPINC1
43dexamethasone45 50 29 1114.0MAOA, AGT
44raloxifene45 29 50 1114.0SERPINE1, SERPINC1, F5, NOS3
45fenofibrate45 50 1112.9LEP, NOS3, SERPINE1, VCAM1
46glutathion4510.8EPHX1, GSTP1
47h2o24510.8FLT1, AGT, MAOA, LEP
48warfarin45 50 11 2413.8SERPINC1, EPHX1, APOH
49diphenyleneiodonium4510.8VCAM1, SOD1
50coumarins4510.4MAOA, APOH

GO Terms for genes affiliated with Pre-Eclampsia

Sources:
16Gene Ontology
See all sources

Cellular components related to Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4SOD1, F5, AGT, IGFBP1, TAC3, LEP
2extracellular spaceGO:00561511.4SERPINC1, SOD1, APOH, FLT1, F5, AGT

Biological processes related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.2SOD1, F5, NOS3, SERPINE1, SERPINC1
2regulation of blood pressureGO:00821711.2NOS3, SOD1, CORIN, LEP
3positive regulation of superoxide anion generationGO:03293011.1GSTP1, SOD1, AGT
4positive regulation of cytokine productionGO:00181911.1LEP, AGT, SOD1
5negative regulation of endopeptidase activityGO:01095111.1SERPINE1, SERPINC1, AGT
6positive regulation of MAPK cascadeGO:04341011.0LEP, AGT, FLT1
7female pregnancyGO:00756511.0TAC3, CORIN, LEP
8regulation of renal sodium excretionGO:03581311.0AGT, CORIN
9ovulation from ovarian follicleGO:00154210.9LEP, NOS3
10platelet degranulationGO:00257610.9SOD1, F5, SERPINE1
11negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.8SERPINE1, NOS3
12negative regulation of fibrinolysisGO:05191810.8APOH, SERPINE1
13positive regulation of angiogenesisGO:04576610.7FLT1, NOS3, SERPINE1
14leukocyte tethering or rollingGO:05090110.7LEP, VCAM1
15negative regulation of blood coagulationGO:03019510.7APOH, SERPINE1
16positive regulation of blood coagulationGO:03019410.4SERPINE1, APOH

Molecular functions related to Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.8SERPINC1, SERPINE1, AGT
2primary amine oxidase activityGO:00813110.4VCAM1, MAOA

Products for genes affiliated with Pre-Eclampsia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Pre-Eclampsia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet