MCID: PRC016
MIFTS: 56

Pre-Eclampsia

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Pre-Eclampsia

MalaCards integrated aliases for Pre-Eclampsia:

Name: Pre-Eclampsia 12 42 14 69
Pregnancy Associated Hypertension 12 69
Proteinuric Hypertension of Pregnancy 12
Transient Hypertension of Pregnancy 69
Hypertension Induced by Pregnancy 12
Gestational Hypertension 12
Pre-Eclamptic Toxaemia 12
Preeclampsia/eclampsia 12
Toxaemia of Pregnancy 12
Pregnancy Toxemia 12
Preeclampsia 12

Classifications:



Summaries for Pre-Eclampsia

Disease Ontology : 12 A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.

MalaCards based summary : Pre-Eclampsia, also known as pregnancy associated hypertension, is related to preeclampsia/eclampsia 1 and severe pre-eclampsia, and has symptoms including edema, hyperemesis gravidarum and morning sickness. An important gene associated with Pre-Eclampsia is STOX1 (Storkhead Box 1), and among its related pathways/superpathways are VEGF Pathway (Qiagen) and VEGF Signaling Pathway. The drugs Methyldopa and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include endothelial, placenta and testes, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 72 Pre-eclampsia (PE) is a disorder of pregnancy characterized by the onset of high blood pressure and... more...

Related Diseases for Pre-Eclampsia

Diseases in the Eclampsia family:

Pre-Eclampsia Severe Pre-Eclampsia

Diseases related to Pre-Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
id Related Disease Score Top Affiliating Genes
1 preeclampsia/eclampsia 1 28.5 AGT CORIN EDN1 ENG EPHX1 FLT1
2 severe pre-eclampsia 12.7
3 mild pre-eclampsia 12.5
4 eclampsia 11.9
5 preeclampsia/eclampsia 4 11.7
6 preeclampsia/eclampsia 5 11.7
7 hellp syndrome 11.6
8 gestational diabetes 11.4
9 acitretin/etretinate embryopathy 10.8 FLT1 PGF VEGFA
10 coloboma of superior eyelid 10.8 FLT1 PGF VEGFA
11 salivary gland adenoid cystic carcinoma 10.8 ENG FLT1 VEGFA
12 sydenham chorea 10.7 ENG FLT1 PGF
13 mitral valve stenosis 10.7 ENG FLT1 VEGFA
14 hypertonia 10.7 MTHFR NOS3 VEGFA
15 cryptosporidiosis 10.7 MTHFR PGF VEGFA
16 hidradenoma 10.6 FLT1 PGF VEGFA
17 endotheliitis 10.6
18 citrullinemia, adult-onset type ii 10.6 FLT1 NOS3 PGF VEGFA
19 3-methylglutaconic aciduria 10.6 PAPPA PGF VEGFA
20 kidney pelvis papillary carcinoma 10.6 FLT1 VEGFA
21 vernal conjunctivitis 10.5 FLT1 MTHFR VEGFA
22 breast disease 10.5 MTHFR PAPPA PGF
23 necrotic uveal melanoma 10.5 MTHFR PAPPA PGF
24 colorectal adenoma 10.5 NOS3 VEGFA
25 progressive black carbon hyperpigmentation of infancy 10.5 EDN1 NOS3
26 lethal congenital contractural syndrome 2 10.5 EDN1 NOS3 VEGFA
27 traumatic glaucoma 10.4 EDN1 NOS3 PGF
28 exophthalmic ophthalmoplegia 10.4 HLA-G LGALS13 PGF VEGFA
29 holoprosencephaly 10.4 ENG NOS3 VEGFA
30 esophageal leukoplakia 10.4 EDN1 NOS3 VEGFA
31 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.4 EDN1 FLT1 NOS3 VEGFA
32 capillary hemangioma 10.3 EDN1 MTHFR NOS3
33 renal fibrosis 10.3 EDN1 NOS3 PGF VEGFA
34 bernard-soulier syndrome, type a2 10.3 EDN1 MTHFR NOS3
35 pregnancy loss, recurrent 1 10.3 HLA-G MTHFR
36 aortopulmonary window 10.3 AGT EDN1 NOS3
37 hypoxia 10.3
38 ulcerative stomatitis 10.3 AGT ENG FLT1 MTHFR PGF
39 periampullary adenoma 10.3 EDN1 NOS3 VEGFA
40 bubonic plague 10.2 EDN1 NOS3 VEGFA
41 prieto syndrome 10.2
42 cerebritis 10.2
43 postpartum psychosis 10.2
44 familial hypertension 10.2
45 joint disorders 10.2 AGT EDN1 MTHFR NOS3
46 thrombophilia 10.1
47 placental abruption 10.1
48 placental insufficiency 10.1
49 lubani-al saleh-teebi syndrome 10.1 EDN1 ENG FLT1 NOS3 VEGFA
50 retinitis 10.1

Graphical network of the top 20 diseases related to Pre-Eclampsia:



Diseases related to Pre-Eclampsia

Symptoms & Phenotypes for Pre-Eclampsia

UMLS symptoms related to Pre-Eclampsia:


edema, hyperemesis gravidarum, morning sickness

MGI Mouse Phenotypes related to Pre-Eclampsia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 AGT CORIN EDN1 ENG FLT1 NOS3
2 growth/size/body region MP:0005378 9.93 AGT CORIN EDN1 ENG FLT1 INHBB
3 homeostasis/metabolism MP:0005376 9.83 EDN1 ENG EPHX1 FLT1 HLA-G INHBB
4 muscle MP:0005369 9.23 FLT1 INHBB NOS3 VEGFA AGT CORIN

Drugs & Therapeutics for Pre-Eclampsia

Drugs for Pre-Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 385)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4,Phase 2,Phase 1 555-30-6 38853
2
Remifentanil Approved Phase 4,Phase 2,Phase 1 132875-61-7 60815
3
Selenium Approved, Vet_approved Phase 4,Phase 2,Phase 3 7782-49-2
4
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
6
Dalteparin Approved Phase 4,Phase 2,Phase 3 9005-49-6
7
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3 9005-49-6 772 46507594
8
Zinc Approved Phase 4,Phase 2,Phase 3 7440-66-6 32051 23994
9
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
10
Oxymetazoline Approved Phase 4 1491-59-4 4636
11
Phenylephrine Approved Phase 4 59-42-7 6041
12
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
13
Labetalol Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 36894-69-6 3869
14
Misoprostol Approved Phase 4,Phase 3,Phase 1,Phase 2 59122-46-2 5282381
15
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 7487-88-9 24083
16
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 2180-92-9, 38396-39-3 2474
17
Levobupivacaine Approved Phase 4 27262-47-1 92253
18
Furosemide Approved, Vet_approved Phase 4,Phase 2 54-31-9 3440
19
Captopril Approved Phase 4 62571-86-2 44093
20
Clonidine Approved Phase 4,Phase 1,Phase 2 4205-90-7 2803
21
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
22
Insulin Aspart Approved Phase 4 116094-23-6 16132418
23
Insulin Lispro Approved Phase 4 133107-64-9
24
Glyburide Approved Phase 4 10238-21-8 3488
25
Calcium Carbonate Approved Phase 4 471-34-1
26
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
27
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
28
Nifedipine Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 21829-25-4 4485
29
Thrombin Approved Phase 4
30
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
31
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
32
Desogestrel Approved Phase 4 54024-22-5 40973
33
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
34
Amlodipine Approved Phase 4 88150-42-9 2162
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1 59-30-3 6037
36
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 143 6006
37
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 67-97-0 6221 10883523 5280795
38
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 50-14-6 5280793
39
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 1406-16-2
40 tannic acid Approved, Nutraceutical Phase 4,Phase 3
41 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
42 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
44 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Phase 1
45 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
46 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
47 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Sympatholytics Phase 4,Phase 2,Phase 1,Early Phase 1
50 Analgesics Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 533)

id Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia Unknown status NCT00117546 Phase 4 alpha methyldopa
3 Remifentanil for General Anesthesia in Preeclamptics Unknown status NCT00567957 Phase 4 Remifentanil;Saline
4 Viagra for the Treatment of IUGR Unknown status NCT00347867 Phase 4 Viagra administration in IUGR/PET pregnancies
5 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
6 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
7 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
8 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
9 Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
10 A Study of Cerebral-circulatory Response to Intravenous Antihypertensive Treatment in Women With Serious Preeclampsia Completed NCT00403572 Phase 4
11 Hemodynamic Measurements in Women With Serious Preeclampsia Completed NCT00199810 Phase 4
12 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
13 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid;Acetylsalicylic Acid
14 Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
15 A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
16 Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
17 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
18 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
19 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4 metformin;insulin
20 Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients Completed NCT02466204 Phase 4 corifollitropin alfa;Follitropin Beta
21 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4 Glyburide;Placebo
22 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Recruiting NCT03233880 Phase 4 Azithromycin 1gm
23 Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Recruiting NCT03164304 Phase 4 Magnesium Sulfate
24 Low Dose Calcium to Prevent Preeclampsia Recruiting NCT02338687 Phase 4
25 Phenylephrine Versus Ephedrine in Pre-eclampsia Recruiting NCT02025426 Phase 4 Phenylephrine;Ephedrine
26 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
27 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
28 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Recruiting NCT02891174 Phase 4 Ibuprofen;Acetaminophen
29 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
30 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Recruiting NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
31 Chronotherapy With Low-dose Aspirin for Primary Prevention Recruiting NCT00725127 Phase 4 aspirin;aspirin
32 Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Recruiting NCT03177122 Phase 4 Myo-inositol
33 A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor Recruiting NCT02777190 Phase 4 Misoprostol
34 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
35 Pharmacokinetics of Amlodipine Besylate at Delivery and During Lactation Active, not recruiting NCT02353806 Phase 4 Amlodipine besylate
36 Effect of Administering Intravenous Magnesium Sulfate on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients Not yet recruiting NCT03237000 Phase 4 MgSO4
37 Failure Rate of GLyburide And Metformin Among Gestational Diabetics Not yet recruiting NCT03078725 Phase 4 Glyburide;Metformin
38 LMWH to Prevent Preeclampsia and Fetal Growth Restriction Terminated NCT00260520 Phase 4 Dalteparin
39 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
40 Comparison of Awakening Versus Bedtime Dosing of Aspirin in Pre-Hypertension or Mild Essential Hypertension Terminated NCT00449618 Phase 4 Aspirin 100 mg;Placebo
41 Atenativ Effect on Uterine Blood Flow and Preeclampsia Withdrawn NCT02278575 Phase 4 Atenativ
42 Low Dose Aspirin for the Prevention of Preeclampsia Unknown status NCT01890005 Phase 3 Aspirin;Placebo
43 PP13 and Doppler Study to Predict Preeclampsia Unknown status NCT00928213 Phase 2, Phase 3 Progesterone;Low molecular weight Heparin;No Drug
44 Investigating the Novel Observation of Right-Left Difference in Uterine Artery Vascular Resistance in Pre-Eclampsia Unknown status NCT00848679 Phase 3 Epidural lidocaine;Epidural lidocaine 2%
45 Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine Unknown status NCT00409253 Phase 3 URAPIDIL (EUPRESSYL*);NICARDIPINE
46 Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia Unknown status NCT01382732 Phase 3 Carbetocin;Oxytocin
47 Randomized Clinical Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients. Unknown status NCT02050529 Phase 2, Phase 3 Labetalol;Hydralazine
48 A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy Unknown status NCT02032186 Phase 3 Magnesium citrate
49 Effect of Micronutrients and Exercise During Pregnancy on Factors Related With Non-Transmissible Chronic Diseases Unknown status NCT00872365 Phase 2, Phase 3
50 Heparin for Pregnant Women With Thrombophilia Unknown status NCT01019655 Phase 3 Nadroparin calcium

Search NIH Clinical Center for Pre-Eclampsia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: pre-eclampsia

Genetic Tests for Pre-Eclampsia

Anatomical Context for Pre-Eclampsia

MalaCards organs/tissues related to Pre-Eclampsia:

39
Endothelial, Placenta, Testes, Liver, Lung, Kidney, Thyroid

Publications for Pre-Eclampsia

Articles related to Pre-Eclampsia:

(show top 50) (show all 1502)
id Title Authors Year
1
Pre-eclampsia: Molecular events to biomarkers. ( 28924318 )
2017
2
Pre-eclampsia is primarily a placental disorder: FOR: Pre-eclampsia is primarily a placental disorder. ( 28921791 )
2017
3
Preterm pre-eclampsia: What every neonatologist should know. ( 28917582 )
2017
4
Shared biomarkers between female diastolic heart failure and pre-eclampsia: a systematic review and meta-analysis. ( 28451444 )
2017
5
The altered PD-1/PD-L1 pathway delivers the 'one-two punch' effects to promote the Treg/Th17 imbalance in pre-eclampsia. ( 28890543 )
2017
6
Catechol-O-methyltransferase Gene Polymorphism (Val158Met) and Development of Pre-eclampsia. ( 28625321 )
2017
7
Cardiac diastolic function after recovery from pre-eclampsia. ( 28906533 )
2017
8
A randomised controlled trial of consumption of dark chocolate in pregnancy to reduce pre-eclampsia: Difficulties in recruitment, allocation and adherence. ( 28913824 )
2017
9
Levels of serum-circulating angiogenic factors within 1 week prior to delivery are closely related to conditions of pregnant women with pre-eclampsia, gestational hypertension, and/or fetal growth restriction. ( 28929598 )
2017
10
Re: Pre-eclampsia: an important risk factor for asymptomatic heart failure. C. Ghossein-Doha, J. van Neer, B. Wissink, N. Breetveld, L. J. de Windt, A. P. J. van Dijk, M. J. van der Vlugt, M. C. H. Janssen, W. M. Heidema, R. R. Scholten and M. E. A. Spaanderman. Ultrasound Obstet Gynecol 2017; 49: 143-149. ( 28058791 )
2017
11
Re: Lung and cardiac ultrasound for hemodynamic monitoring of patients with severe pre-eclampsia. J. Ambrozic, G. Brzan Simenc, K. Prokselj, N. Tulz, M. Cvijic and M. Lucovnik. Ultrasound Obstet Gynecol 2017; 49: 104-109. ( 28058788 )
2017
12
Evaluation of Placental mir-155-5p and Long Non-coding RNA sONE Expression in Patients with Severe Pre-eclampsia. ( 28868266 )
2017
13
Determinants of pre-eclampsia/Eclampsia among women attending delivery Services in Selected Public Hospitals of Addis Ababa, Ethiopia: a case control study. ( 28915802 )
2017
14
Re: Serious maternal complications in relation to severe pre-eclampsia: a retrospective cohort study of the impact of hospital volume; Severe maternal morbidity requires regionalisation of obstetric critical care; Guilt, blame and litigation: can an overenthusiastic 'safety culture' cause harm?: Maternal mortality: the heavy psychological burden on centre obstetricians. ( 28670731 )
2017
15
Validation of fullPIERS model for prediction of adverse outcomes among women with severe pre-eclampsia. ( 28475234 )
2017
16
Evaluation of the predictive value of placental vascularisation indices derived from 3-Dimensional power Doppler whole placental volume scanning for prediction of pre-eclampsia: A systematic review and meta-analysis. ( 28089506 )
2017
17
Screening for pre-eclampsia in the first trimester: what do we still need to know before starting? ( 28850746 )
2017
18
Response to: Using Carbon Monoxide Releasing Molecules in Models of Pre-Eclampsia: When Should We Be Monitoring Vascular Effects? ( 28911026 )
2017
19
Maternal bradycardia occurring prior to onset of HELLP syndrome in a woman with pre-eclampsia. ( 28501825 )
2017
20
Re: Endothelial dysfunction and vascular stiffness in women with previous pregnancy complicated by early or late pre-eclampsia. R. Orabona, E. Sciatti, E. Vizzardi, I. Bonadei and A. Valcamonico. Ultrasound Obstet Gynecol 2017; 49: 116-123. ( 28058790 )
2017
21
Comment on: Maternal pre-eclampsia as a risk factor for necrotizing enterocolitis. ( 28911253 )
2017
22
Association between interleukin-4 polymorphisms and risk of pre-eclampsia in a population of Chinese pregnant women. ( 28387873 )
2017
23
Severe pre-eclampsia before 26A weeks of gestation: how should we counsel women? ( 28229528 )
2017
24
Pre-eclampsia is primarily a placental disorder: AGAINST: Pre-eclampsia: the heart matters. ( 28921798 )
2017
25
Lung and cardiac ultrasound for hemodynamic monitoring of patients with severe pre-eclampsia. ( 27736042 )
2017
26
Pre-eclampsia: Screening and aspirin therapy for prevention of pre-eclampsia. ( 28869248 )
2017
27
Treatment using tadalafil for severe pre-eclampsia with fetal growth restriction. ( 28503744 )
2017
28
Assessment of quality of care among in-patients with postpartum haemorrhage and severe pre-eclampsia at st. Francis hospital nsambya: a criteria-based audit. ( 28086822 )
2017
29
Circulating adipokines are associated with pre-eclampsia in women with type 1 diabetes. ( 28875223 )
2017
30
Hypertension: A new genetic clue to unravel the origins of pre-eclampsia. ( 28869250 )
2017
31
Evaluation of agreement of placental growth factor (PlGF) tests and the soluble FMS-like tyrosine kinase 1 (sFlt-1)/PlGF ratio, comparison of predictive accuracy for pre-eclampsia, and relation to uterine artery Doppler and response to aspirin. ( 28851242 )
2017
32
Validation of Fetal Medicine Foundation algorithm for prediction of pre-eclampsia in the first trimester in an unselected Brazilian population. ( 28889785 )
2017
33
Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia. ( 27746364 )
2017
34
Prediction of severe pre-eclampsia by a combination of sFlt-1, CT-pro ET1 and blood pressure: exploratory study. ( 28643875 )
2017
35
Epigallocatechin gallate enhances treatment efficacy of oral nifedipine against pregnancy-induced severe pre-eclampsia: A double-blind, randomized and placebo-controlled clinical study. ( 28726273 )
2017
36
MiR-210 and miR-155 as potential diagnostic markers for pre-eclampsia pregnancies. ( 28700503 )
2017
37
Accuracy of competing risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation. ( 28067011 )
2017
38
Introduction of management protocol for early-onset severe pre-eclampsia. ( 28150368 )
2017
39
The effects of sildenafil citrate on uterine angiogenic status and serum inflammatory markers in an L-NAME rat model of pre-eclampsia. ( 27940055 )
2017
40
Serious Visual (Ocular) Complications in Pre-eclampsia and Eclampsia. ( 28867885 )
2017
41
Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion. ( 28232601 )
2017
42
What are the metabolic precursors which increase the risk of pre-eclampsia and how could these be investigated further. ( 28855067 )
2017
43
Toward a better understanding of the oocyte donation/pre-eclampsia connection. ( 27140289 )
2016
44
Expression of the complement system's activation factors in plasma of patients with early/late-onset severe pre-eclampsia. ( 27461873 )
2016
45
Prospective assessment of neurodevelopment in children following a pregnancy complicated by severe pre-eclampsia. ( 27388354 )
2016
46
A pre-eclampsia-associated Epstein-Barr virus antibody cross-reacts with placental GPR50. ( 27181993 )
2016
47
Maternal Circulating microRNAs and Pre-Eclampsia: Challenges for Diagnostic Potential. ( 27638415 )
2016
48
Predictive value of 4-, 8-, and 12-h urine protein and protein-to-creatinine ratio for detection of pre-eclampsia. ( 27113418 )
2016
49
Polymorphisms of the IL27 gene in a Chinese Han population complicated with pre-eclampsia. ( 26971578 )
2016
50
Heart Disease, hypertension, gestational diabetes and pre-eclampsia/eclampsia in mothers with juvenile arthritis: A nested case-control study. ( 27111101 )
2016

Variations for Pre-Eclampsia

ClinVar genetic disease variations for Pre-Eclampsia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NOS3 NM_000603.4(NOS3): c.894T> G (p.Asp298Glu) single nucleotide variant risk factor rs1799983 GRCh37 Chromosome 7, 150696111: 150696111
2 NSD1 NM_022455.4(NSD1): c.6050G> A (p.Arg2017Gln) single nucleotide variant Pathogenic/Likely pathogenic rs587784177 GRCh37 Chromosome 5, 176710828: 176710828

Expression for Pre-Eclampsia

Search GEO for disease gene expression data for Pre-Eclampsia.

Pathways for Pre-Eclampsia

GO Terms for Pre-Eclampsia

Cellular components related to Pre-Eclampsia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 AGT CORIN EDN1 FLT1 INHBB PAPPA
2 extracellular space GO:0005615 9.28 AGT EDN1 ENG FLT1 INHBB PAPPA

Biological processes related to Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 AGT EDN1 FLT1 PGF STOX1 VEGFA
2 response to hypoxia GO:0001666 9.81 EDN1 MTHFR PGF VEGFA
3 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.73 FLT1 PGF VEGFA
4 angiogenesis GO:0001525 9.72 ENG FLT1 NOS3 PGF VEGFA
5 positive regulation of MAP kinase activity GO:0043406 9.7 EDN1 FLT1 VEGFA
6 positive regulation of endothelial cell migration GO:0010595 9.65 AGT EDN1 VEGFA
7 positive regulation of cardiac muscle hypertrophy GO:0010613 9.61 AGT EDN1
8 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.61 AGT VEGFA
9 vasoconstriction GO:0042310 9.6 AGT EDN1
10 nitric oxide mediated signal transduction GO:0007263 9.59 AGT NOS3
11 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.58 FLT1 VEGFA
12 induction of positive chemotaxis GO:0050930 9.58 PGF VEGFA
13 positive regulation of renal sodium excretion GO:0035815 9.57 AGT EDN1
14 response to transforming growth factor beta GO:0071559 9.55 EDN1 ENG
15 artery smooth muscle contraction GO:0014824 9.54 AGT EDN1
16 branching involved in blood vessel morphogenesis GO:0001569 9.54 EDN1 ENG VEGFA
17 positive regulation of mast cell chemotaxis GO:0060754 9.49 PGF VEGFA
18 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.46 EDN1 NOS3
19 regulation of blood pressure GO:0008217 9.46 AGT CORIN EDN1 NOS3
20 regulation of renal sodium excretion GO:0035813 9.43 AGT CORIN
21 regulation of blood vessel size GO:0050880 9.43 AGT EDN1 NOS3
22 positive regulation of angiogenesis GO:0045766 9.35 ENG FLT1 NOS3 PGF VEGFA
23 female pregnancy GO:0007565 9.02 AGT CORIN PAPPA PGF TAC3

Molecular functions related to Pre-Eclampsia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 AGT EDN1 INHBB
2 growth factor activity GO:0008083 9.26 AGT INHBB PGF VEGFA
3 vascular endothelial growth factor receptor binding GO:0005172 8.62 PGF VEGFA

Sources for Pre-Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
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