MCID: PRC016
MIFTS: 56

Pre-Eclampsia malady

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Pre-Eclampsia

Aliases & Descriptions for Pre-Eclampsia:

Name: Pre-Eclampsia 12 42 14 69
Pregnancy Associated Hypertension 12 69
Preeclampsia 12 14
Proteinuric Hypertension of Pregnancy 12
Transient Hypertension of Pregnancy 69
Hypertension Induced by Pregnancy 12
Gestational Hypertension 12
Pre-Eclamptic Toxaemia 12
Preeclampsia/eclampsia 12
Toxaemia of Pregnancy 12
Pregnancy Toxemia 12

Classifications:



Summaries for Pre-Eclampsia

Disease Ontology : 12 A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy.

MalaCards based summary : Pre-Eclampsia, also known as pregnancy associated hypertension, is related to severe pre-eclampsia and mild pre-eclampsia, and has symptoms including edema, hyperemesis gravidarum and morning sickness. An important gene associated with Pre-Eclampsia is STOX1 (Storkhead Box 1), and among its related pathways/superpathways are Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers and Signaling events mediated by VEGFR1 and VEGFR2. The drugs Methyldopa and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and testes, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Pre-Eclampsia

Diseases in the Eclampsia family:

Pre-Eclampsia Severe Pre-Eclampsia

Diseases related to Pre-Eclampsia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)
id Related Disease Score Top Affiliating Genes
1 severe pre-eclampsia 12.7
2 mild pre-eclampsia 12.5
3 eclampsia 11.9
4 preeclampsia/eclampsia 5 11.7
5 preeclampsia/eclampsia 4 11.7
6 preeclampsia/eclampsia 1 11.7
7 hellp syndrome 11.6
8 gestational diabetes 11.4
9 endotheliitis 10.6
10 isolated plagiocephaly 10.4 FLT1 PGF VEGFA
11 neuropathy with hearing impairment 10.4 FLT1 PGF VEGFA
12 kidney osteogenic sarcoma 10.3 FLT1 MMP9 VEGFA
13 mucinoses 10.3 ADIPOQ LEP VCAM1
14 acrocephalopolydactyly 10.3 ADIPOQ LEP
15 hepatic vascular disease 10.3 LEP MMP9 VEGFA
16 vulvitis 10.3 FLT1 LEP PGF VEGFA
17 parameningeal embryonal rhabdomyosarcoma 10.3 PAPPA PGF VEGFA
18 maxillary neoplasm 10.3 FLT1 MMP9 VEGFA
19 hypoxia 10.3
20 cortical blindness mental retardation polydactyly 10.3 ADIPOQ LEP VCAM1
21 hyperlipoproteinemia type iv 10.3 ADIPOQ ALB LEP
22 vernal conjunctivitis 10.3 ALB FLT1 VEGFA
23 spinocerebellar ataxia 25 10.3 ALB F5 VEGFA
24 epidermolysis bullosa simplex, sutosomal recessive 2 10.3 FLT1 MMP9 VCAM1 VEGFA
25 capillary hemangioma 10.2 ALB SERPINC1 VEGFA
26 eagle syndrome 10.2 ALB F5 SERPINC1
27 citrullinemia, type ii, neonatal-onset 10.2 ALB FLT1 PGF VCAM1 VEGFA
28 alcoholic gastritis 10.2 ALB F5 SERPINC1
29 central nervous system leiomyoma 10.2 ALB IGFBP1 LEP
30 cholesteatoma 10.2 ADIPOQ ALB LEP
31 histiocytoid hemangioma 10.2 ALB MMP9 VEGFA
32 congenital chloride diarrhea 10.2 ALB SERPINC1 VCAM1 VEGFA
33 cerebritis 10.2
34 prieto syndrome 10.2
35 med13l syndrome 10.2 APOH F5
36 postpartum psychosis 10.2
37 familial hypertension 10.2
38 mucopolysaccharidosis iii 10.2 ADIPOQ ALB LEP
39 autoimmune-related retinopathy and optic neuropathy 10.2 ADIPOQ MMP9 VCAM1 VEGFA
40 stt3a-cdg and stt3b-cdg 10.2 F5 SERPINC1
41 lung cancer 10.2 APOH F5 HLA-G
42 achard thiers syndrome 10.2 APOH F5
43 aminoaciduria 10.2 F5 MMP9
44 neurofibroma of the heart 10.2 ALB F5 SERPINC1
45 thrombophilia 10.1
46 placental abruption 10.1
47 placental insufficiency 10.1
48 antidepressant type abuse 10.1 ADIPOQ LEP LNPEP PAPPA
49 vascular erectile tumor 10.1 APOH F5 SERPINC1
50 hypertrichosis 10.1 APOH F5 SERPINC1

Graphical network of the top 20 diseases related to Pre-Eclampsia:



Diseases related to Pre-Eclampsia

Symptoms & Phenotypes for Pre-Eclampsia

UMLS symptoms related to Pre-Eclampsia:


edema, hyperemesis gravidarum, morning sickness

MGI Mouse Phenotypes related to Pre-Eclampsia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 TAC3 VCAM1 VEGFA ADIPOQ ALB APOH
2 cardiovascular system MP:0005385 10.21 ADIPOQ CORIN F5 FLT1 LEP LNPEP
3 growth/size/body region MP:0005378 10.18 ADIPOQ CORIN F5 FLT1 INHBB LEP
4 immune system MP:0005387 10.06 LEP MMP9 PGF SERPINC1 VCAM1 VEGFA
5 integument MP:0010771 9.86 ADIPOQ CORIN F5 INHBB LEP MMP9
6 liver/biliary system MP:0005370 9.7 ADIPOQ ALB F5 IGFBP1 LEP SERPINC1
7 muscle MP:0005369 9.56 ADIPOQ ALB CORIN FLT1 INHBB LEP
8 renal/urinary system MP:0005367 9.17 LEP MMP9 SERPINC1 VEGFA ADIPOQ ALB

Drugs & Therapeutics for Pre-Eclampsia

Drugs for Pre-Eclampsia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 366)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4,Phase 2,Phase 1 555-30-6 38853
2
Remifentanil Approved Phase 4,Phase 2,Phase 1 132875-61-7 60815
3
Selenium Approved, Vet_approved Phase 4,Phase 2,Phase 3 7782-49-2
4
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
6
Dalteparin Approved Phase 4,Phase 2,Phase 3 9041-08-1
7
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3 9005-49-6 772 46507594
8
Zinc Approved Phase 4,Phase 2,Phase 3 7440-66-6 32051 23994
9
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
10
Oxymetazoline Approved Phase 4 1491-59-4 4636
11
Phenylephrine Approved Phase 4 59-42-7 6041
12
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
13
Labetalol Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 36894-69-6 3869
14
Misoprostol Approved Phase 4,Phase 3,Phase 1,Phase 2 59122-46-2 5282381
15
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 7487-88-9 24083
16
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 2180-92-9, 38396-39-3 2474
17
Levobupivacaine Approved Phase 4 27262-47-1 92253
18
Furosemide Approved, Vet_approved Phase 4,Phase 2 54-31-9 3440
19
Captopril Approved Phase 4 62571-86-2 44093
20
Clonidine Approved Phase 4,Phase 1,Phase 2 4205-90-7 2803
21
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
22
Insulin Lispro Approved Phase 4 133107-64-9
23
Glyburide Approved Phase 4 10238-21-8 3488
24
Calcium carbonate Approved Phase 4 471-34-1
25
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
26
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
27
Nifedipine Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 21829-25-4 4485
28
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
29
Desogestrel Approved Phase 4 54024-22-5 40973
30
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
31
Amlodipine Approved Phase 4 88150-42-9 2162
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1 59-30-3 6037
33
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 54575, 6560146 143
34
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 67-97-0 6221 10883523 5280795
35
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 50-14-6 5280793
36 tannic acid Approved, Nutraceutical Phase 4,Phase 3
37 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
40 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Phase 1
41 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
42 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Sympatholytics Phase 4,Phase 2,Phase 1,Early Phase 1
46 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
47 Analgesics, Opioid Phase 4,Phase 3,Phase 2,Phase 1
48 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
49 Anesthetics, General Phase 4,Phase 2,Phase 3,Phase 1
50 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 496)
id Name Status NCT ID Phase
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4
2 Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia Unknown status NCT00117546 Phase 4
3 Remifentanil for General Anesthesia in Preeclamptics Unknown status NCT00567957 Phase 4
4 Viagra for the Treatment of IUGR Unknown status NCT00347867 Phase 4
5 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
6 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4
7 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
8 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4
9 Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia Completed NCT02699827 Phase 4
10 A Study of Cerebral-circulatory Response to Intravenous Antihypertensive Treatment in Women With Serious Preeclampsia Completed NCT00403572 Phase 4
11 Hemodynamic Measurements in Women With Serious Preeclampsia Completed NCT00199810 Phase 4
12 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4
13 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4
14 Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia Completed NCT01408979 Phase 4
15 A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen Completed NCT02091401 Phase 4
16 Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4
17 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4
18 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4
19 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4
20 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4
21 Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Recruiting NCT03164304 Phase 4
22 Low Dose Calcium to Prevent Preeclampsia Recruiting NCT02338687 Phase 4
23 Phenylephrine Versus Ephedrine in Pre-eclampsia Recruiting NCT02025426 Phase 4
24 Atenativ Effect on Uterine Blood Flow and Preeclampsia Recruiting NCT02278575 Phase 4
25 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Recruiting NCT02911701 Phase 4
26 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4
27 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Recruiting NCT02891174 Phase 4
28 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4
29 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Recruiting NCT01912677 Phase 4
30 Chronotherapy With Low-dose Aspirin for Primary Prevention Recruiting NCT00725127 Phase 4
31 Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Recruiting NCT03177122 Phase 4
32 A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor Recruiting NCT02777190 Phase 4
33 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4
34 Pharmacokinetics of Amlodipine Besylate at Delivery and During Lactation Active, not recruiting NCT02353806 Phase 4
35 Failure Rate of GLyburide And Metformin Among Gestational Diabetics Not yet recruiting NCT03078725 Phase 4
36 LMWH to Prevent Preeclampsia and Fetal Growth Restriction Terminated NCT00260520 Phase 4
37 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4
38 Comparison of Awakening Versus Bedtime Dosing of Aspirin in Pre-Hypertension or Mild Essential Hypertension Terminated NCT00449618 Phase 4
39 Low Dose Aspirin for the Prevention of Preeclampsia Unknown status NCT01890005 Phase 3
40 PP13 and Doppler Study to Predict Preeclampsia Unknown status NCT00928213 Phase 2, Phase 3
41 Investigating the Novel Observation of Right-Left Difference in Uterine Artery Vascular Resistance in Pre-Eclampsia Unknown status NCT00848679 Phase 3
42 Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine Unknown status NCT00409253 Phase 3
43 Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia Unknown status NCT01382732 Phase 3
44 Randomized Clinical Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients. Unknown status NCT02050529 Phase 2, Phase 3
45 A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy Unknown status NCT02032186 Phase 3
46 Effect of Micronutrients and Exercise During Pregnancy on Factors Related With Non-Transmissible Chronic Diseases Unknown status NCT00872365 Phase 2, Phase 3
47 Heparin for Pregnant Women With Thrombophilia Unknown status NCT01019655 Phase 3
48 Folic Acid Dosage and Malformations Reduction Unknown status NCT01244347 Phase 3
49 Efficacy and Safety of L Arginine to Prevent Preeclampsia Completed NCT02363348 Phase 3
50 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3

Search NIH Clinical Center for Pre-Eclampsia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: pre-eclampsia

Genetic Tests for Pre-Eclampsia

Anatomical Context for Pre-Eclampsia

MalaCards organs/tissues related to Pre-Eclampsia:

39
Placenta, Endothelial, Testes, Neutrophil, Liver, Kidney, Nk Cells

Publications for Pre-Eclampsia

Articles related to Pre-Eclampsia:

(show top 50) (show all 1467)
id Title Authors Year
1
Re: Lung and cardiac ultrasound for hemodynamic monitoring of patients with severe pre-eclampsia. J. Ambrozic, G. Brzan Simenc, K. Prokselj, N. Tulz, M. Cvijic and M. Lucovnik. Ultrasound Obstet Gynecol 2017; 49: 104-109. ( 28058788 )
2017
2
Accuracy of competing risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation. ( 28067011 )
2017
3
Evaluation of the predictive value of placental vascularisation indices derived from 3-Dimensional power Doppler whole placental volume scanning for prediction of pre-eclampsia: A systematic review and meta-analysis. ( 28089506 )
2017
4
Lung and cardiac ultrasound for hemodynamic monitoring of patients with severe pre-eclampsia. ( 27736042 )
2017
5
Assessment of quality of care among in-patients with postpartum haemorrhage and severe pre-eclampsia at st. Francis hospital nsambya: a criteria-based audit. ( 28086822 )
2017
6
Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia. ( 27746364 )
2017
7
Association between interleukin-4 polymorphisms and risk of pre-eclampsia in a population of Chinese pregnant women. ( 28387873 )
2017
8
The effects of sildenafil citrate on uterine angiogenic status and serum inflammatory markers in an L-NAME rat model of pre-eclampsia. ( 27940055 )
2017
9
Re: Pre-eclampsia: an important risk factor for asymptomatic heart failure. C. Ghossein-Doha, J. van Neer, B. Wissink, N. Breetveld, L. J. de Windt, A. P. J. van Dijk, M. J. van der Vlugt, M. C. H. Janssen, W. M. Heidema, R. R. Scholten and M. E. A. Spaanderman. Ultrasound Obstet Gynecol 2017; 49: 143-149. ( 28058791 )
2017
10
Re: Endothelial dysfunction and vascular stiffness in women with previous pregnancy complicated by early or late pre-eclampsia. R. Orabona, E. Sciatti, E. Vizzardi, I. Bonadei and A. Valcamonico. Ultrasound Obstet Gynecol 2017; 49: 116-123. ( 28058790 )
2017
11
Prospective assessment of neurodevelopment in children following a pregnancy complicated by severe pre-eclampsia. ( 27388354 )
2016
12
Serious maternal complications in relation to severe pre-eclampsia: a retrospective cohort study of the impact of hospital volume. ( 27770512 )
2016
13
A pre-eclampsia-associated Epstein-Barr virus antibody cross-reacts with placental GPR50. ( 27181993 )
2016
14
Diagnostic accuracy of spot urine protein-to-creatinine ratio for proteinuria and its association with adverse pregnancy outcomes in Chinese pregnant patients with pre-eclampsia. ( 27149973 )
2016
15
EP17.16: Angiogenic factors and uterine artery Doppler for prediction of pre-eclampsia in high-risk population. ( 27644456 )
2016
16
Evaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia. ( 26382559 )
2016
17
Helicobacter pylori infection and pre-eclampsia in a Romanian study group. ( 27612532 )
2016
18
Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. ( 27646865 )
2016
19
Assessment of angiogenesis modulators in pregnant women with pre-eclampsia: a case-control study. ( 26205065 )
2016
20
EP17.17: Preconceptional fat mass and hemodynamic evaluation as early predictor of pre-eclampsia risk. ( 27644709 )
2016
21
Plasma PP13 and urinary GAGs/PGs as early markers of pre-eclampsia. ( 27161490 )
2016
22
Placental hypoxia, endoplasmic reticulum stress and maternal endothelial sensitisation by sFLT1 in pre-eclampsia. ( 26228018 )
2016
23
Optimizing treatment for the prevention of pre-eclampsia/eclampsia in Nepal: is calcium supplementation during pregnancy cost-effective? ( 28035193 )
2016
24
Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC). ( 28067621 )
2016
25
Heart Disease, hypertension, gestational diabetes and pre-eclampsia/eclampsia in mothers with juvenile arthritis: A nested case-control study. ( 27111101 )
2016
26
The Expression of T-Helper Associated Transcription Factors and Cytokine Genes in Pre-Eclampsia. ( 27999241 )
2016
27
Fetal sex-specific differences in gestational age at delivery in pre-eclampsia: a meta-analysis. ( 27605586 )
2016
28
Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. ( 27094586 )
2016
29
Ibuprofen versus acetaminophen as a post-partum analgesic for women with severe pre-eclampsia: randomized clinical study. ( 27384376 )
2016
30
Toward a better understanding of the oocyte donation/pre-eclampsia connection. ( 27140289 )
2016
31
Antenatal corticosteroid therapy for foetal maturation in women with eclampsia and severe pre-eclampsia in a rural hospital in Western Tanzania. ( 27543098 )
2016
32
OS 23-03 MID-TRIMESTER RISK PREDICTION OF SUPERIMPOSED PRE-ECLAMPSIA IN PREGNANT WOMEN WITH CHRONIC HYPERTENSION. ( 27643043 )
2016
33
Tumor Necrosis Factor-I+ and Interleukin-1-I^ Polymorphisms in Pre-Eclampsia. ( 27999242 )
2016
34
Predictive value of 4-, 8-, and 12-h urine protein and protein-to-creatinine ratio for detection of pre-eclampsia. ( 27113418 )
2016
35
First trimester screening for pre-eclampsia. ( 27630745 )
2016
36
Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method. ( 27196639 )
2016
37
Associations between pre-eclampsia and protein C and proteinA S levels among pregnant Nigerian women. ( 28092096 )
2016
38
Serum markers of pre-eclampsia identified on proteomics. ( 27279411 )
2016
39
EP17.18: Comparison of perinatal outcomes in early- and late-onset pre-eclampsia. ( 27644986 )
2016
40
Translational studies for exercise in high-risk pregnancy: Pre-eclampsia model. ( 27159274 )
2016
41
OS 04-03 EVALUATION OF THE DIAGNOSTIC VALUE OF THE FIRST TRIMESTER MATERNAL SERUM HIGH SENSITIVE C-REACTIVE PROTEIN (HS-CRP) LEVEL FOR PREDICTION OF PRE-ECLAMPSIA. ( 27643304 )
2016
42
The Pre-Eclampsia Ontology: A Disease Ontology Representing the Domain Knowledge Specific to Pre-Eclampsia. ( 27788142 )
2016
43
EP17.15: Prediction of pre-eclampsia and IUGR by uterine artery Doppler sonography. ( 27644183 )
2016
44
Cardiac arrest during emergency cesarean section for severe pre-eclampsia and peripartum cardiomyopathy. ( 26927264 )
2016
45
Author's reply re: Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case control study. ( 27531337 )
2016
46
Evaluation of fetal hypermethylated RASSF1A in pre-eclampsia and its relationship with placental protein-13, pregnancy associated plasma protein-A and urine protein. ( 27939474 )
2016
47
Twin Chorionicity and the Risk of Hypertensive Disorders: Gestational Hypertension and Pre-eclampsia. ( 27160962 )
2016
48
Re: Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case control study: Effect of timing of extracorporeal membrane oxygenation during HELLP syndrome. ( 27531338 )
2016
49
Ovarian reserve in women with a previous history of severe pre-eclampsia. ( 27604242 )
2016
50
Antiphospholipid antibodies and the risk of severe and non-severe pre-eclampsia: the NOHA case-control study. ( 26782635 )
2016

Variations for Pre-Eclampsia

ClinVar genetic disease variations for Pre-Eclampsia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NOS3 NM_000603.4(NOS3): c.894T> G (p.Asp298Glu) single nucleotide variant risk factor rs1799983 GRCh37 Chromosome 7, 150696111: 150696111
2 NSD1 NM_022455.4(NSD1): c.6050G> A (p.Arg2017Gln) single nucleotide variant Pathogenic/Likely pathogenic rs587784177 GRCh37 Chromosome 5, 176710828: 176710828

Expression for Pre-Eclampsia

Search GEO for disease gene expression data for Pre-Eclampsia.

Pathways for Pre-Eclampsia

GO Terms for Pre-Eclampsia

Cellular components related to Pre-Eclampsia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ADIPOQ ALB APOH CORIN F5 FLT1
2 cell surface GO:0009986 9.65 ADIPOQ APOH CORIN VCAM1 VEGFA
3 extracellular space GO:0005615 9.5 ADIPOQ ALB APOH F5 FLT1 IGFBP1
4 platelet alpha granule lumen GO:0031093 9.33 ALB F5 VEGFA

Biological processes related to Pre-Eclampsia according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 FLT1 LEP PGF STOX1 VEGFA
2 angiogenesis GO:0001525 9.83 FLT1 LEP PGF VEGFA
3 cellular protein metabolic process GO:0044267 9.72 ALB F5 IGFBP1 PAPPA SERPINC1
4 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.67 FLT1 PGF VEGFA
5 platelet degranulation GO:0002576 9.67 ALB APOH F5 VEGFA
6 regulation of blood pressure GO:0008217 9.65 CORIN LEP LNPEP
7 leukocyte tethering or rolling GO:0050901 9.57 LEP VCAM1
8 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.56 FLT1 VEGFA
9 induction of positive chemotaxis GO:0050930 9.55 PGF VEGFA
10 cellular response to leptin stimulus GO:0044320 9.51 INHBB LEP
11 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.46 HLA-G LNPEP
12 response to nutrient GO:0007584 9.46 ADIPOQ LEP SERPINC1 VCAM1
13 positive regulation of follicle-stimulating hormone secretion GO:0046881 9.43 INHBB LEP
14 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.43 FLT1 VCAM1 VEGFA
15 positive regulation of mast cell chemotaxis GO:0060754 9.4 PGF VEGFA
16 response to hypoxia GO:0001666 9.35 ADIPOQ LEP PGF VCAM1 VEGFA
17 female pregnancy GO:0007565 9.1 CORIN LEP LNPEP PAPPA PGF TAC3

Molecular functions related to Pre-Eclampsia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.65 ADIPOQ HLA-G IGFBP1 LEP TAC3
2 growth factor activity GO:0008083 9.46 INHBB LEP PGF VEGFA
3 heparin binding GO:0008201 9.26 APOH PGF SERPINC1 VEGFA
4 vascular endothelial growth factor receptor binding GO:0005172 8.62 PGF VEGFA

Sources for Pre-Eclampsia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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