MCID: PRC016
MIFTS: 79

Pre-Eclampsia malady

Reproductive diseases, Rare diseases, Cardiovascular diseases categories

Summaries for Pre-Eclampsia

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OMIM:46 Preeclampsia, which along with chronic hypertension and gestational hypertension comprise the hypertensive disorders of... (189800) more...

MalaCards based summary: Pre-Eclampsia, also known as preeclampsia, is related to eclampsia and severe pre-eclampsia, and has symptoms including autosomal dominant inheritance, proteinuria and hypertension. An important gene associated with Pre-Eclampsia is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Dopamine metabolism. The drug magnesium sulfate and the compounds apocynin and amlodipine have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and liver, and related mouse phenotypes are muscle and renal/urinary system.

Disease Ontology:9 A hypertension occurring during pregnancy also characterized by large amounts of protein in the urine.

Genetics Home Reference:22 Preeclampsia is a complication of pregnancy in which affected women develop high blood pressure (hypertension) and can also have abnormally high levels of protein in their urine. This condition usually occurs in the last few months of pregnancy and often requires the early delivery of the infant.

Wikipedia:64 Pre-eclampsia or preeclampsia is a disorder of pregnancy characterized by high blood pressure and large... more...

Descriptions from OMIM:46 609404,609402,614592,609403,614595

Aliases & Classifications for Pre-Eclampsia

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Sources:
9Disease Ontology, 10diseasecard, 22Genetics Home Reference, 46OMIM, 11DISEASES, 44Novoseek, 48Orphanet, 61UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 28ICD9CM, 27ICD10 via Orphanet, 62UMLS via Orphanet, 26ICD10
See all sources

Pre-Eclampsia, Aliases & Descriptions:

Name: Pre-Eclampsia 9 22 11 61
Preeclampsia 9 22 46 44 48
Proteinuric Hypertension of Pregnancy 9 61
Hypertension Induced by Pregnancy 9 61
Pre-Eclamptic Toxaemia 9 61
Toxaemia of Pregnancy 9 61
Gestational Proteinuric Hypertension 22
Pregnancy Associated Hypertension 9
Hypertension, Pregnancy-Induced 46
 
Preeclampsia, Susceptibility to 10
Pregnancy-Induced Hypertension 22
Gestational Hypertension 9
Preeclampsia/eclampsia 9
Toxemia of Pregnancy 22
Toxemias, Pregnancy 61
Pregnancy Toxemias 44
Toxemia, Pregnancy 61
Pregnancy Toxemia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Reproductive diseases, Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

48
preeclampsia:
Prevalence: 1-5/10000


Related Diseases for Pre-Eclampsia

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Diseases in the Pre-Eclampsia family:

Eclampsia Severe Pre-Eclampsia

Diseases related to Pre-Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 257)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia33.4HLA-G, SERPINC1
2severe pre-eclampsia32.2F5, GSTP1, MAOA, VCAM1, SERPINC1, SERPINE1
3hellp syndrome31.9APOH, SERPINE1, SERPINC1, GSTP1, F5
4mild pre-eclampsia31.9IGFBP1, SOD1, VCAM1
5placental insufficiency31.6IGFBP1, FLT1
6placental abruption31.5SERPINC1, F5
7thrombophilia31.5F5, SERPINC1, SERPINE1, APOH
8hypertension31.3LEP, SERPINE1, VCAM1, F5, NOS3, AGT
9pregnancy loss31.2F5, SERPINC1, APOH, HLA-G
10antiphospholipid syndrome31.1APOH, SERPINC1, VCAM1, F5
11thrombocytopenia31.0F5, SERPINC1, APOH
12central retinal vein occlusion31.0F5, APOH
13vascular disease31.0SERPINC1, APOH
14bronchopulmonary dysplasia30.9FLT1, SOD1
15hyperinsulinism30.9IGFBP1, LEP, SERPINE1
16portal vein thrombosis30.9SERPINC1, F5
17retinal vein occlusion30.9F5, SERPINC1, APOH
18antithrombin iii deficiency30.9APOH, SERPINC1, F5
19disseminated intravascular coagulation30.9SERPINE1, SERPINC1, F5
20lupus erythematosus30.9F5, SERPINC1, APOH
21purpura30.9SERPINC1
22polycystic ovary syndrome30.9IGFBP1, LEP, SERPINE1
23glucose intolerance30.8IGFBP1, LEP, SERPINE1
24thrombophlebitis30.7APOH
25proteinuria30.6HLA-G, APOH, FLT1, NOS3, AGT
26infertility30.6IGFBP1, HLA-G, LEP
27sepsis30.6NOS3, F5, SERPINC1, SERPINE1
28protein s deficiency30.5APOH, SERPINE1, SERPINC1, F5
29essential hypertension30.5HLA-G, LEP, SERPINE1, SOD1, NOS3, AGT
30endometriosis30.5IGFBP1, HLA-G, FLT1
31insulin resistance30.5IGFBP1, LEP, SERPINE1, VCAM1, NOS3, AGT
32diabetes mellitus30.4IGFBP1, LEP, SERPINE1, SERPINC1, SOD1, VCAM1
33thromboembolism30.3APOH, SERPINE1, SERPINC1, F5, NOS3
34obesity30.3IGFBP1, LEP, SERPINE1, FLT1, MAOA, NOS3
35type 1 diabetes mellitus30.3AGT, LEP, IGFBP1
36breast cancer30.2IGFBP1, HLA-G, LEP, SERPINE1, FLT1, EPHX1
37adenoma30.2IGFBP1, HLA-G, FLT1, EPHX1, GSTP1
38ischemia29.9SOD1, FLT1, NOS3, AGT
39diabetic retinopathy29.9IGFBP1, SERPINE1, SOD1, FLT1, VCAM1, NOS3
40hyperglycemia29.9IGFBP1, LEP, SERPINE1, SOD1, VCAM1, NOS3
41hyperhomocysteinemia29.9APOH, SERPINE1, SERPINC1, SOD1, VCAM1, F5
42myocardial infarction29.6IGFBP1, SERPINE1, SERPINC1, F5, NOS3, AGT
43atherosclerosis29.2LEP, APOH, SERPINE1, SERPINC1, SOD1, FLT1
44endotheliitis11.0
45hypoxia10.7
46retinal artery occlusion10.6APOH
47carotid artery thrombosis10.6SERPINE1
48branch retinal artery occlusion10.6F5
49eales disease10.6SOD1
50blindness10.6

Graphical network of the top 20 diseases related to Pre-Eclampsia:



Diseases related to pre-eclampsia

Symptoms for Pre-Eclampsia

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Symptoms by clinical synopsis from OMIM:

189800

Clinical features from OMIM:

609404,609402,614592,189800,609403,614595

HPO human phenotypes related to Pre-Eclampsia:

(show all 9)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 proteinuria HP:0000093
3 hypertension HP:0000822
4 edema HP:0000969
5 seizures HP:0001250
6 intrauterine growth retardation HP:0001511
7 thrombocytopenia HP:0001873
8 elevated hepatic transaminases HP:0002910
9 maternal hypertension HP:0008071

Drugs & Therapeutics for Pre-Eclampsia

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Drug clinical trials:

Search ClinicalTrials for Pre-Eclampsia

Search NIH Clinical Center for Pre-Eclampsia

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Pre-Eclampsia

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Anatomical Context for Pre-Eclampsia

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MalaCards organs/tissues related to Pre-Eclampsia:

32
Placenta, Endothelial, Liver, Kidney, Brain, Lung, Testes, Neutrophil, Nk cells, Breast, T cells, Heart, Pancreas, Thyroid, Myeloid, Whole blood, Retina, Colon, Skin, Ovary, Monocytes, B cells, Fetal lung, Pituitary

Animal Models for Pre-Eclampsia or affiliated genes

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Publications for Pre-Eclampsia

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Articles related to Pre-Eclampsia:

(show top 50)    (show all 1269)
idTitleAuthorsYear
1
Comparison of serum maternal adiponectin concentrations in women with isolated intrauterine growth retardation and intrauterine growth retardation concomitant with pre-eclampsia. (25317046)
2014
2
A report from #BlueJC: Can measuring angiogenic factors help with predicting preterm pre-eclampsia in low-risk women? (24428457)
2014
3
Pre-eclampsia or chronic kidney disease? The flow hypothesis. (23314318)
2013
4
A case-control study of placental lesions associated with pre-eclampsia. (23200099)
2013
5
Aspirin for pre-eclampsia: beware of subgroup meta-analysis. (23610032)
2013
6
Development of maternal and neonatal composite outcomes for trials evaluating management of late-onset pre-eclampsia. (24303960)
2013
7
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
8
Uterine artery Doppler and sFlt-1/PlGF ratio: usefulness in diagnosis of pre-eclampsia. (23303638)
2013
9
Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women. (22540831)
2012
10
Improving diagnosis and clinical management of pre-eclampsia. (22452158)
2012
11
Hemodynamic evaluation and anti-hypertensive schemes used in puerperal women following pre-eclampsia. (22561779)
2012
12
Unilateral focal renal artery stenosis complicated by early onset superimposed pre-eclampsia. (22663329)
2012
13
Contribution of PARP to endothelial dysfunction and hypertension in a rat model of pre-eclampsia. (22339234)
2012
14
Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia--a case-control study. (21534854)
2011
15
An unexpected tail of VEGF and PlGF in pre-eclampsia. (22103490)
2011
16
Fractional excretion of urea in pre-eclampsia: a clinical observation. (22057072)
2011
17
Aortic intima-media thickness and lipid profile in neonates born to mothers with pre-eclampsia: weak or strong relations? (21932615)
2011
18
A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes. (21340620)
2011
19
Plasminogen activator inhibitor-1 gene polymorphisms in pre-eclampsia. (21370208)
2011
20
A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women. (21973132)
2011
21
Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. (21946915)
2011
22
PP13 as a marker of pre-eclampsia: A two platform comparison study. (21257081)
2011
23
Gene modification with integrin-linked kinase improves function of endothelial progenitor cells in pre-eclampsia in vitro. (21688303)
2011
24
Quantitative detection of the hypermethylated RASSF1A gene in maternal plasma of pre-eclampsia]. (20140873)
2010
25
Role of inflammatory cytokines and eNOS gene polymorphism in pathophysiology of pre-eclampsia. (20047583)
2010
26
Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (19108943)
2009
27
Profile of serum soluble endoglin in pregnant women with severe pre-eclampsia and eclampsia]. (19570416)
2009
28
Predictors and risk factors of pre-eclampsia. (18854808)
2008
29
The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell-free DNA and mRNA in normal pregnancy and pre-eclampsia. (18834630)
2008
30
Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia. (18226121)
2008
31
ADAM12s in maternal serum as a potential marker of pre-eclampsia. (18264967)
2008
32
Altered plasma neurokinin B levels in patients with pre-eclampsia. (17318561)
2007
33
Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes. (17167268)
2007
34
Overproduction of the follistatin-related gene protein in the placenta and maternal serum of women with pre-eclampsia. (17617189)
2007
35
Association between a functional dopamine D4 receptor promoter region polymorphism (-C521T) and pre-eclampsia: a family-based study. (16455620)
2006
36
Three mechanisms in the pathogenesis of pre-eclampsia suggested by over-represented transcription factor-binding sites detected with comparative promoter analysis. (16403800)
2006
37
Oxidative stress is closely related to clinical severity of pre-eclampsia. (16874398)
2006
38
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. (15280126)
2004
39
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. (14673478)
2004
40
Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study. (12653685)
2003
41
Soluble adhesion molecules: marker of pre-eclampsia and intrauterine growth restriction. (12422906)
2002
42
Oxidant stress in pre-eclampsia and essential hypertension. (12583464)
2002
43
Activation of the novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia. (11554693)
2001
44
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. (10965192)
2000
45
Neutrophil CD11B expression and neutrophil activation in pre-eclampsia. (9038589)
1997
46
Endothelin-1 stimulates the proliferation and invasion of first trimester trophoblastic cells in vitro--a possible role in the etiology of pre-eclampsia? (8952225)
1996
47
Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension. (8730885)
1996
48
The effect of severe pre-eclampsia on the pancreas: changes in the serum cationic trypsinogen and pancreatic amylase. (2447935)
1987
49
Severe pre-eclampsia of early onset. (6196074)
1983
50
The management of severe pre-eclampsia. (1050623)
1976

Variations for Pre-Eclampsia

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Clinvar genetic disease variations for Pre-Eclampsia:

7
id Gene Name Type Significance SNP ID Assembly Location
1STOX1NM_001130161.2(STOX1): c.457T> C (p.Tyr153His)single nucleotide variantrisk factorrs1341667GRCh37Chr 10, 70641860: 70641860
2STOX1NM_001130161.2(STOX1): c.1824A> C (p.Glu608Asp)single nucleotide variantPathogenicrs10509305GRCh37Chr 10, 70645376: 70645376
3CORINNM_006587.3(CORIN): c.949A> G (p.Lys317Glu)single nucleotide variantPathogenicrs387906894GRCh37Chr 4, 47685820: 47685820
4CORINNM_006587.3(CORIN): c.1414A> G (p.Ser472Gly)single nucleotide variantPathogenicrs387906895GRCh37Chr 4, 47667224: 47667224

Expression for genes affiliated with Pre-Eclampsia

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Expression patterns in normal tissues for genes affiliated with Pre-Eclampsia

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Pathways for genes affiliated with Pre-Eclampsia

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Compounds for genes affiliated with Pre-Eclampsia

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Compounds related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 187)
idCompoundScoreTop Affiliating Genes
1apocynin44 6011.4NOS3, AGT, VCAM1, SOD1
2amlodipine44 50 25 1213.4VCAM1, AGT, SERPINE1, NOS3
3l-nmma4410.3LEP, NOS3, VCAM1, SOD1, AGT
4n(g)-nitro-l-arginine methyl ester4410.3LEP, SOD1, SERPINE1, AGT, NOS3
5tibolone4410.3F5, LEP, SERPINC1, SERPINE1
6ancrod4410.3SERPINC1, SERPINE1, F5
78-isoprostane4410.2APOH, SOD1, VCAM1, NOS3, SERPINE1, LEP
8uric acid44 2511.2LEP, SOD1, SERPINE1, APOH, F5
9sodium nitroprusside4410.2SOD1, LEP, SERPINE1, VCAM1, NOS3
10atorvastatin44 50 29 25 1214.2SERPINE1, AGT, VCAM1, F5, NOS3
11p0034410.2LEP, FLT1, SERPINE1, EPHX1, HLA-G, APOH
12rosiglitazone29 44 50 25 1214.1IGFBP1, NOS3, SERPINE1, LEP, VCAM1
13p0024410.1IGFBP1, F5, APOH, FLT1, LEP
14diphenyleneiodonium4410.1SOD1, NOS3, AGT, VCAM1
15folate4410.1NOS3, SERPINC1, APOH, GSTP1, VCAM1, F5
16raloxifene44 50 29 1213.1SERPINE1, F5, NOS3, SERPINC1
17methotrexate50 44 1212.1NOS3, GSTP1, SERPINE1, APOH, LEP, HLA-G
18homocysteine44 2511.1SERPINC1, AGT, NOS3, F5, VCAM1, SERPINE1
19tamoxifen44 50 29 1213.1F5, NOS3, VCAM1, SERPINC1, LEP, IGFBP1
20aspirin44 50 29 2513.1NOS3, F5, GSTP1, SERPINC1, SERPINE1, APOH
21simvastatin44 50 60 29 25 1215.1AGT, VCAM1, NOS3, SERPINE1, F5
22genistein44 29 60 3 25 1215.1NOS3, GSTP1, VCAM1, AGT, FLT1, SERPINE1
23epinephrine44 25 1212.1AGT, F5, GSTP1, MAOA, LEP, IGFBP1
24cyclophosphamide44 50 1212.1VCAM1, APOH, SERPINE1, EPHX1, GSTP1, F5
25n acetylcysteine4410.1LEP, VCAM1, SERPINC1, AGT, SOD1, GSTP1
26glutathion4410.0GSTP1, EPHX1, SOD1
27fenofibrate44 50 1212.0LEP, VCAM1, NOS3, SERPINE1
28warfarin44 50 25 1213.0F5, EPHX1, SERPINC1, APOH
29phosphatidylinositol4410.0AGT, NOS3, EPHX1, VCAM1, FLT1, APOH
30lactate4410.0SOD1, HLA-G, IGFBP1, APOH, VCAM1, GSTP1
31fibrinogen449.9AGT, VCAM1, SERPINE1, APOH, LEP, IGFBP1
32superoxide44 2510.9EPHX1, SOD1, APOH, AGT, NOS3, TAC3
33dexamethasone44 50 29 1212.9IGFBP1, HLA-G, LEP, SERPINE1, SERPINC1, VCAM1
34h2o2449.9FLT1, AGT, MAOA, GSTP1, SOD1, LEP
35ascorbic acid44 2510.9SERPINC1, LEP, EGLN2, NOS3, F5, GSTP1
36progesterone44 29 60 25 1213.8SERPINE1, LEP, IGFBP1, HLA-G, APOH, F5
37heparin44 29 25 1212.8AGT, IGFBP1, SERPINE1, FLT1, SERPINC1, APOH
38testosterone44 60 25 1212.8IGFBP1, LEP, VCAM1, MAOA, GSTP1, F5
39nitric oxide44 25 1211.8FLT1, SOD1, F5, SERPINE1, IGFBP1, APOH
40cysteine449.8LEP, AGT, F5, GSTP1, MAOA, VCAM1
41cholesterol44 29 25 1212.8AGT, IGFBP1, HLA-G, LEP, APOH, SERPINE1
42prostacyclin449.8NOS3, AGT, APOH, F5, VCAM1, FLT1
43lipid449.7SOD1, FLT1, LEP, APOH, VCAM1, HLA-G
44oxygen44 2510.6AGT, APOH, IGFBP1, SOD1, FLT1, VCAM1
45arginine449.6VCAM1, SOD1, IGFBP1, LEP, APOH, SERPINC1
46serine449.6GSTP1, CORIN, VCAM1, NOS3, SERPINC1, LEP
47creatinine449.6SOD1, FLT1, GSTP1, F5, SERPINC1, SERPINE1
48glycerol44 25 1211.6NOS3, LEP, GSTP1, SERPINC1, IGFBP1
49estrogen449.4LEP, APOH, SERPINE1, SERPINC1, FLT1, VCAM1
50vegf449.3AGT, IGFBP1, EGLN2, NOS3, HLA-G, LEP

GO Terms for genes affiliated with Pre-Eclampsia

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Cellular components related to Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.3SERPINE1, SERPINC1, SOD1, FLT1, VCAM1, CORIN
2extracellular regionGO:0055769.1AGT, IGFBP1, TAC3, F5, CORIN, SOD1
3extracellular spaceGO:0056158.9SOD1, F5, TAC3, AGT, VCAM1, FLT1

Biological processes related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1regulation of renal sodium excretionGO:03581310.6AGT, CORIN
2ovulation from ovarian follicleGO:00154210.5LEP, NOS3
3positive regulation of cytokine productionGO:00181910.5LEP, SOD1, AGT
4positive regulation of superoxide anion generationGO:03293010.5AGT, GSTP1, SOD1
5positive regulation of MAPK cascadeGO:04341010.4AGT, FLT1, LEP
6female pregnancyGO:00756510.4LEP, CORIN, TAC3
7leukocyte tethering or rollingGO:05090110.4VCAM1, LEP
8negative regulation of fibrinolysisGO:05191810.4SERPINE1, APOH
9regulation of blood pressureGO:00821710.4NOS3, CORIN, SOD1, LEP
10platelet degranulationGO:00257610.4F5, SOD1, SERPINE1
11positive regulation of angiogenesisGO:04576610.4SERPINE1, FLT1, NOS3
12negative regulation of endopeptidase activityGO:01095110.3AGT, SERPINC1, SERPINE1
13positive regulation of blood coagulationGO:03019410.3APOH, SERPINE1
14nitric oxide mediated signal transductionGO:00726310.3AGT, NOS3
15negative regulation of blood coagulationGO:03019510.3SERPINE1, APOH
16blood coagulationGO:00759610.2SERPINE1, SERPINC1, SOD1, F5, NOS3
17cellular response to vascular endothelial growth factor stimulusGO:03592410.2FLT1, VCAM1
18response to hypoxiaGO:00166610.1EGLN2, VCAM1, LEP
19negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.0NOS3, SERPINE1

Molecular functions related to Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.1VCAM1, MAOA
2serine-type endopeptidase inhibitor activityGO:0048679.8AGT, SERPINC1, SERPINE1
3protein bindingGO:0055159.1AGT, APOH, SERPINE1, SERPINC1, SOD1, FLT1

Products for genes affiliated with Pre-Eclampsia

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Sources for Pre-Eclampsia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet