MCID: PRC016
MIFTS: 75

Pre-Eclampsia malady

Reproductive diseases category

Summaries for Pre-Eclampsia

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Sources:
21Genetics Home Reference, 63Wikipedia, 46OMIM, 32MalaCards
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Genetics Home Reference:21 Preeclampsia is a complication of pregnancy in which affected women develop high blood pressure (hypertension) and can also have abnormally high levels of protein in their urine. This condition usually occurs in the last few months of pregnancy and often requires the early delivery of the infant.

MalaCards: Pre-Eclampsia, also known as preeclampsia, is related to eclampsia and severe pre-eclampsia. An important gene associated with Pre-Eclampsia is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are HIF-1 signaling pathway and HIF-1-alpha transcription factor network. The drug magnesium sulfate and the compounds vegf and creatinine have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and testes, and related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:63 Pre-eclampsia or preeclampsia is a multi system disorder characterized by high blood pressure and... more...

Description from OMIM:46 189800,609404,609402,609403,614595

Aliases & Classifications for Pre-Eclampsia

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Sources:
8Disease Ontology, 21Genetics Home Reference, 10DISEASES, 60UMLS, 46OMIM, 44Novoseek, 48Orphanet, 9diseasecard, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Characteristics (Orphanet epidemiological data):

48
preeclampsia:
Prevalence: 1-5/10000


Aliases & Descriptions:

pre-eclampsia 8 21 10 60
preeclampsia 8 21 46 44 48
hypertension induced by pregnancy 8 60
pregnancy-induced hypertension 8 21
toxemia of pregnancy 8 21
proteinuric hypertension of pregnancy 8
gestational proteinuric hypertension 21
pregnancy associated hypertension 8
preeclampsia, susceptibility to 9
hypertension, pregnancy-induced 46
hypertension of pregnancy nos 8
gestational hypertension 8
preeclampsia/eclampsia 8
pre-eclamptic toxaemia 8
toxaemia of pregnancy 8
hypertension of preg. 8
pregnancy toxemias 44
pre-eclamptic nos 8
pregnancy toxemia 8
pre-eclampsia nos 8
toxaemia nos 8
toxemia nos 8


External Ids:

Disease Ontology8 DOID:10591
MeSH34 D011225
SNOMED-CT via Orphanet57 15394000, 398254007
ICD10 via Orphanet26 O14.1, O14.2, O14.9 O13, O14.0, O11, more
ICD1025 O13, O14

Related Diseases for Pre-Eclampsia

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Pre-Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 277)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia32.4HLA-G, SERPINC1
2severe pre-eclampsia31.9APOH, HLA-G, F5, IGFBP1, MAOA, LEP
3hypertension31.4F5, AGT, LEP, NOS3, VCAM1, SERPINE1
4hellp syndrome31.2APOH, F5, SERPINE1, SERPINC1, GSTP1
5mild pre-eclampsia31.1SOD1, IGFBP1, VCAM1
6proteinuria30.7APOH, HLA-G, FLT1, AGT, NOS3
7thrombophilia30.7APOH, F5, SERPINE1, SERPINC1
8placental insufficiency30.7FLT1, IGFBP1
9diabetes mellitus30.6SOD1, AGT, IGFBP1, LEP, NOS3, VCAM1
10essential hypertension30.6SOD1, HLA-G, AGT, LEP, NOS3, SERPINE1
11placental abruption30.6SERPINC1, F5
12hepatitis30.6IGFBP1, EPHX1
13obesity30.5FLT1, AGT, IGFBP1, MAOA, LEP, NOS3
14chorioamnionitis30.5FLT1
15pancreatitis30.4SOD1, GSTP1
16breast cancer30.3HLA-G, FLT1, AGT, IGFBP1, EPHX1, LEP
17antiphospholipid syndrome30.3APOH, F5, VCAM1, SERPINC1
18thrombocytopenia30.3APOH, F5, SERPINC1
19lupus erythematosus30.1SERPINC1, F5, APOH
20choriocarcinoma30.1LEP, FLT1, HLA-G
21hyperinsulinism30.1IGFBP1, LEP, SERPINE1
22disseminated intravascular coagulation30.1F5, SERPINE1, SERPINC1
23retinopathy of prematurity30.1FLT1
24vascular disease30.1SOD1, APOH, F5, AGT, NOS3, VCAM1
25diabetic retinopathy30.1SOD1, FLT1, AGT, IGFBP1, NOS3, VCAM1
26hyperglycemia30.1SOD1, AGT, IGFBP1, LEP, NOS3, VCAM1
27ischemia30.1SOD1, FLT1, AGT, NOS3
28polycystic ovary syndrome30.1IGFBP1, LEP, SERPINE1
29alzheimer's disease30.1GSTP1, NOS3, MAOA, SOD1
30retinal vein occlusion30.1SERPINC1, F5, APOH
31antithrombin iii deficiency30.0APOH, F5, SERPINC1
32migraine30.0MAOA, APOH
33vasculitis30.0VCAM1, APOH
34hypogonadism30.0LEP, TAC3
35central retinal vein occlusion30.0F5, APOH
36portal vein thrombosis30.0F5, SERPINC1
37purpura30.0SERPINC1
38glomerulonephritis30.0VCAM1
39acute pancreatitis30.0SOD1
40down syndrome30.0SOD1
41hypothyroidism30.0LEP
42glucose intolerance29.9SERPINE1, LEP, IGFBP1
43atherosclerosis29.7CORIN, SOD1, APOH, FLT1, AGT, LEP
44hyperhomocysteinemia29.7SOD1, APOH, F5, NOS3, VCAM1, SERPINE1
45myocardial infarction29.7SERPINC1, SERPINE1, NOS3, IGFBP1, AGT, F5
46adenoma29.7HLA-G, FLT1, IGFBP1, EPHX1, GSTP1
47leukemia29.7HLA-G, FLT1, IGFBP1, EPHX1, GSTP1
48chronic kidney failure29.7NOS3, LEP, IGFBP1, AGT, SOD1
49endometriosis29.7HLA-G, FLT1, IGFBP1
50infertility29.7HLA-G, IGFBP1, LEP

Graphical network of the top 20 diseases related to Pre-Eclampsia:



Diseases related to pre-eclampsia

Clinical Features for Pre-Eclampsia

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

189800,609404,609402,609403,614595

Clinical synopsis from OMIM:

189800

Drugs & Therapeutics for Pre-Eclampsia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Pre-Eclampsia

Drug clinical trials:

Search ClinicalTrials for Pre-Eclampsia

Search NIH Clinical Center for Pre-Eclampsia

Search CenterWatch for Pre-Eclampsia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Pre-Eclampsia

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Anatomical Context for Pre-Eclampsia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Pre-Eclampsia:

32
Placenta, Endothelial, Testes, Liver, Nk cells, Kidney, T cells, Breast, Myeloid, Thyroid, Pancreas, Heart, Brain, B cells, Fetal lung, Whole blood, Monocytes, Ovary, Skin, Lung, Colon, Retina, Pituitary

Animal Models for Pre-Eclampsia or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Pre-Eclampsia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.3SERPINC1, CORIN, SOD1, APOH, HLA-G, EGLN2
2MP:000538711.7SOD1, HLA-G, EGLN2, FLT1, AGT, IGFBP1
3MP:001076811.7APOH, FLT1, F5, AGT, TAC3, LEP
4MP:000538511.6CORIN, SOD1, EGLN2, FLT1, AGT, MAOA
5MP:000537011.6SOD1, EGLN2, F5, AGT, IGFBP1, LEP
6MP:000539711.4SOD1, HLA-G, EGLN2, FLT1, LEP, NOS3
7MP:000536910.9CORIN, SOD1, EGLN2, FLT1, AGT, LEP
8MP:000538910.7EGLN2, FLT1, SERPINC1

Publications for Pre-Eclampsia

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Sources:
50PubMed
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Articles related to Pre-Eclampsia:

(show top 50)    (show all 1252)
idTitleAuthorsYear
1
PAPPA2 is increased in severe early onset pre-eclampsia and upregulated with hypoxia. (23484525)
2014
2
Comparison of gestational diabetes mellitus and pre-eclampsia in women with high hemoglobin in the first trimester of pregnancy: A longitudinal study. (24353673)
2013
3
Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia. (24304135)
2013
4
Role of Foxp3 gene in maternal susceptibility to pre-eclampsia - a study from South India. (22809231)
2013
5
The polymorphism for endothelial nitric oxide synthase gene, the level of nitric oxide and the risk for pre-eclampsia: a meta-analysis. (23375994)
2013
6
Gene expression profiling of placentae from women with early- and late-onset pre-eclampsia: down-regulation of the angiogenesis-related genes ACVRL1 and EGFL7 in early-onset disease. (22013081)
2012
7
Metastin levels in pregnancies complicated by pre-eclampsia and their relation with disease severity. (22769053)
2012
8
Electrocardiographic findings in women with a recent history of pre-eclampsia. (22122556)
2012
9
Severe pre-eclampsia is associated with abnormal trace elements concentrations in maternal and fetal blood. (22007865)
2012
10
The management of pre-eclampsia: what we think we know. (22036739)
2012
11
The role of angiogenic, anti-angiogenic and vasoactive factors in pre-eclamptic African women: early- versus late-onset pre-eclampsia. (22555639)
2012
12
Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. (21946915)
2011
13
Using clinical symptoms to predict adverse maternal and perinatal outcomes in women with preeclampsia: data from the PIERS (Pre-eclampsia Integrated Estimate of RiSk) study. (21846435)
2011
14
Clinical risk prediction of pre-eclampsia. (21474516)
2011
15
Maternal arterial stiffness in women who subsequently develop pre-eclampsia. (21559278)
2011
16
Is the urine spot protein/creatinine ratio a valid diagnostic test for pre-eclampsia? (21281026)
2011
17
Prediction of pre-eclampsia in early pregnancy by estimating the spot urinary albumin: creatinine ratio using high-performance liquid chromatography. (21481153)
2011
18
Assessment, surveillance and prognosis in pre-eclampsia. (21459048)
2011
19
Determinants of Pre-eclampsia: A Case-control Study in a District Hospital in South India. (21278871)
2010
20
Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia. (20457799)
2010
21
First-trimester maternal serum tumor necrosis factor receptor-1 and pre-eclampsia. (19173240)
2009
22
Genetic polymorphisms in DNA repair gene APE1, XRCC1 and XPD and the risk of pre-eclampsia. (19592152)
2009
23
Predictors and risk factors of pre-eclampsia. (18854808)
2008
24
Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia. (18986700)
2008
25
Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11-14 weeks' gestation. (17221926)
2007
26
Murine pre-eclampsia induced by unspecific activation of the immune system correlates with alterations in the eNOS and AT1 receptor expression in the kidneys and placenta. (17129602)
2007
27
Pre-eclampsia: clinical manifestations and molecular mechanisms. (17570933)
2007
28
Serum magnesium and calcium ions in patients with severe pre-eclampsia/eclampsia undergoing magnesium sulfate therapy. (17392650)
2007
29
Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia. (17210583)
2007
30
Maternal and fetal single nucleotide polymorphisms in the epoxide hydrolase and gluthatione S-transferase P1 genes are not associated with pre-eclampsia in the Coloured population of the Western Cape, South Africa. (16147638)
2004
31
Serum granulysin is a marker for Th1 type immunity in pre-eclampsia. (15030522)
2004
32
Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia. (12651901)
2003
33
Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia. (12737861)
2003
34
Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia. (12757936)
2003
35
Pre-term birth and severe pre-eclampsia are not associated with altered expression of HLA on human trophoblasts. (12852493)
2003
36
The HELPP syndrome--evidence of a possible systemic inflammatory response in pre-eclampsia?]. (12221908)
2002
37
Functional characteristics of chorionic plate placental arteries from normal pregnant women and women with pre-eclampsia. (12517325)
2002
38
Analysis of mid-trimester corticotrophin-releasing hormone and alpha-fetoprotein concentrations for predicting pre-eclampsia. (10920109)
2000
39
Genetic susceptibility to pre-eclampsia and chromosome 7q36. (10647900)
1999
40
Maternal middle cerebral artery velocity changes in HELLP syndrome versus pre-eclampsia. (9589143)
1998
41
Elevations of serum interleukin-12 concentrations in women with severe pre-eclampsia and HELLP syndrome. (8887125)
1996
42
Pulmonary edema in severe pre-eclampsia (a case report). (2634761)
1989
43
The effect of severe pre-eclampsia on the pancreas: changes in the serum cationic trypsinogen and pancreatic amylase. (2447935)
1987
44
Severe pre-eclampsia and infants of very low birth weight. (3632019)
1987
45
Serial plasma oncotic pressure levels and echoencephalography during and after delivery in severe pre-eclampsia. (2860445)
1985
46
Triploidy syndrome with theca lutein cysts and severe pre-eclampsia. (760530)
1979
47
Severe pre-eclampsia with concealed antepartum haemorrhage. (5196537)
1969
48
Spontaneous hematoma of the liver in a woman with severe pre-eclampsia. (13016689)
1953
49
Hydatidiform mole complicated by severe pre-eclampsia. (13010040)
1953
50
Treatment of a case of severe pre-eclampsia with concentrated serum albumin, salt-poor. (18883079)
1948

Genetic Variations for Pre-Eclampsia

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Expression for genes affiliated with Pre-Eclampsia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Pre-Eclampsia

Search GEO for disease gene expression data for Pre-Eclampsia.

Pathways for genes affiliated with Pre-Eclampsia

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 49PharmGKB
See all sources

Compounds for genes affiliated with Pre-Eclampsia

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB, 49PharmGKB
See all sources

Compounds related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 148)
idCompoundScoreTop Affiliating Genes
1vegf4412.3APOH, AGT, F5, EGLN2, HLA-G, IGFBP1
2creatinine4412.1SERPINC1, F5, SOD1, APOH, HLA-G, FLT1
3arginine4412.1APOH, EPHX1, LEP, NOS3, F5, AGT
4prostacyclin4412.0SOD1, LEP, SERPINC1, SERPINE1, VCAM1, NOS3
5cholesterol44 28 11 2415.0IGFBP1, FLT1, APOH, HLA-G, F5, AGT
6nitric oxide44 11 2414.0SOD1, TAC3, IGFBP1, APOH, FLT1, AGT
7cysteine4411.8LEP, HLA-G, F5, SOD1, AGT, IGFBP1
8ascorbic acid44 2412.8EGLN2, LEP, SOD1, F5, MAOA, NOS3
9fibrinogen4411.8SERPINC1, VCAM1, LEP, AGT, IGFBP1, F5
10testosterone44 59 11 2414.7IGFBP1, MAOA, F5, LEP, VCAM1, GSTP1
11lipid4411.7IGFBP1, FLT1, HLA-G, APOH, AGT, SOD1
12homocysteine44 2412.7AGT, VCAM1, APOH, F5, NOS3, SERPINE1
13superoxide44 2412.7AGT, EPHX1, TAC3, NOS3, VCAM1, APOH
14phosphatidylinositol4411.6NOS3, LEP, EPHX1, IGFBP1, APOH, FLT1
15genistein44 28 59 2 11 2416.6VCAM1, NOS3, AGT, FLT1, IGFBP1, SERPINE1
168-isoprostane4411.6LEP, SOD1, APOH, VCAM1, NOS3, SERPINE1
17lactate4411.6SOD1, HLA-G, APOH, GSTP1, VCAM1, F5
18oxygen44 2412.6FLT1, AGT, IGFBP1, MAOA, EGLN2, HLA-G
19folate4411.5VCAM1, APOH, NOS3, F5, GSTP1, SERPINC1
20aspirin44 49 28 2414.5F5, APOH, NOS3, SERPINE1, SERPINC1, GSTP1
21methotrexate44 49 1113.5SERPINE1, GSTP1, APOH, NOS3, HLA-G, LEP
22epinephrine44 11 2413.4GSTP1, LEP, MAOA, IGFBP1, AGT, F5
23n(g)-nitro-l-arginine methyl ester4411.4AGT, LEP, NOS3, SERPINE1, SOD1
24p0034411.4EPHX1, SERPINE1, APOH, FLT1, HLA-G
25l-nmma4411.4NOS3, AGT, LEP, VCAM1, SOD1
26n acetylcysteine4411.4GSTP1, SERPINC1, VCAM1, LEP, AGT, SOD1
27progesterone44 59 28 11 2415.4IGFBP1, LEP, SERPINE1, F5, APOH, HLA-G
28sodium nitroprusside4411.3SERPINE1, VCAM1, NOS3, SOD1, LEP
29heparin44 28 11 2414.3APOH, FLT1, AGT, VCAM1
30atorvastatin44 49 28 11 2415.3NOS3, VCAM1, SERPINE1, AGT, F5
31cyclophosphamide44 49 1113.3NOS3, APOH, F5, GSTP1
32serine4411.3CORIN, FLT1, LEP, AGT
33p0024411.3APOH, FLT1, IGFBP1, LEP, F5
34tibolone4411.3SERPINE1, F5, LEP, SERPINC1
35apocynin44 5912.3VCAM1, AGT, SOD1, NOS3
36amlodipine44 49 11 2414.3AGT, NOS3, VCAM1, SERPINE1
37simvastatin44 49 59 28 11 2416.2F5, SERPINE1, VCAM1, NOS3, AGT
38tamoxifen44 49 28 1114.2EPHX1, VCAM1, IGFBP1
39uric acid44 2412.2APOH, F5, SERPINE1
40estrogen4411.1TAC3, APOH
41rosiglitazone44 49 28 11 2415.1IGFBP1, VCAM1, LEP
42ancrod4411.0F5, SERPINE1, SERPINC1
43dexamethasone44 49 28 1114.0MAOA, AGT
44raloxifene44 28 49 1114.0SERPINE1, SERPINC1, F5, NOS3
45fenofibrate44 49 1112.9LEP, NOS3, SERPINE1, VCAM1
46glutathion4410.8EPHX1, GSTP1
47h2o24410.8FLT1, AGT, MAOA, LEP
48warfarin44 49 11 2413.8SERPINC1, EPHX1, APOH
49diphenyleneiodonium4410.8VCAM1, SOD1
50coumarins4410.4MAOA, APOH

GO Terms for genes affiliated with Pre-Eclampsia

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Sources:
16Gene Ontology
See all sources

Cellular components related to Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.4SOD1, F5, AGT, IGFBP1, TAC3, LEP
2extracellular spaceGO:00561511.4SERPINC1, SOD1, APOH, FLT1, F5, AGT

Biological processes related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759611.2SOD1, F5, NOS3, SERPINE1, SERPINC1
2regulation of blood pressureGO:00821711.2CORIN, SOD1, LEP, NOS3
3positive regulation of superoxide anion generationGO:03293011.1GSTP1, AGT, SOD1
4positive regulation of cytokine productionGO:00181911.1LEP, AGT, SOD1
5negative regulation of endopeptidase activityGO:01095111.1SERPINC1, SERPINE1, AGT
6positive regulation of MAPK cascadeGO:04341011.0LEP, AGT, FLT1
7female pregnancyGO:00756511.0CORIN, TAC3, LEP
8regulation of renal sodium excretionGO:03581311.0CORIN, AGT
9ovulation from ovarian follicleGO:00154210.9NOS3, LEP
10platelet degranulationGO:00257610.9SOD1, F5, SERPINE1
11negative regulation of fibrinolysisGO:05191810.8SERPINE1, APOH
12negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.8SERPINE1, NOS3
13leukocyte tethering or rollingGO:05090110.7LEP, VCAM1
14negative regulation of blood coagulationGO:03019510.7SERPINE1, APOH
15positive regulation of blood coagulationGO:03019410.6APOH, SERPINE1
16positive regulation of angiogenesisGO:04576610.5FLT1, NOS3, SERPINE1

Molecular functions related to Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00486710.8SERPINC1, SERPINE1, AGT
2primary amine oxidase activityGO:00813110.4VCAM1, MAOA

Products for genes affiliated with Pre-Eclampsia

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  • Antibodies
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Sources for Pre-Eclampsia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet