MCID: PRC016
MIFTS: 74

Pre-Eclampsia malady

Reproductive diseases, Rare diseases, Cardiovascular diseases categories
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Summaries for Pre-Eclampsia

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Sources:
21Genetics Home Reference, 65Wikipedia, 47OMIM, 33MalaCards
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Genetics Home Reference:21 Preeclampsia is a complication of pregnancy in which affected women develop high blood pressure (hypertension) and can also have abnormally high levels of protein in their urine. This condition usually occurs in the last few months of pregnancy and often requires the early delivery of the infant.

MalaCards: Pre-Eclampsia, also known as preeclampsia, is related to eclampsia and severe pre-eclampsia. An important gene associated with Pre-Eclampsia is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are Angiogenesis and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The drug magnesium sulfate and the compounds apocynin and amlodipine have been mentioned in the context of this disorder. Affiliated tissues include placenta, endothelial and liver, and related mouse phenotypes are reproductive system and liver/biliary system.

Wikipedia:65 Pre-eclampsia or preeclampsia is a disorder of pregnancy characterized by high blood pressure and large... more...

Description from OMIM:47 189800,609404,609402,609403,614595

Aliases & Classifications for Pre-Eclampsia

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Sources:
8Disease Ontology, 9diseasecard, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Reproductive diseases, Cardiovascular diseases


Characteristics (Orphanet epidemiological data):

49
preeclampsia:
Prevalence: 1-5/10000


Aliases & Descriptions:

pre-eclampsia 8 21 10 62
preeclampsia 8 21 47 45 49
hypertension induced by pregnancy 8 62
pregnancy-induced hypertension 8 21
toxemia of pregnancy 8 21
proteinuric hypertension of pregnancy 8
gestational proteinuric hypertension 21
pregnancy associated hypertension 8
preeclampsia, susceptibility to 9
hypertension, pregnancy-induced 47
hypertension of pregnancy nos 8
gestational hypertension 8
preeclampsia/eclampsia 8
pre-eclamptic toxaemia 8
hypertension of preg. 8
toxaemia of pregnancy 8
pregnancy toxemias 45
pre-eclamptic nos 8
pregnancy toxemia 8
pre-eclampsia nos 8
toxaemia nos 8
toxemia nos 8


External Ids:

Disease Ontology8 DOID:10591
MeSH35 D011225
SNOMED-CT via Orphanet59 15394000, 398254007
UMLS via Orphanet63 C0032914
ICD10 via Orphanet26 O14.1, O14.2, O14.9 O13, O14.0, O11, more
ICD1025 O13, O14

Related Diseases for Pre-Eclampsia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Pre-Eclampsia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia32.6HLA-G, SERPINC1
2severe pre-eclampsia32.0IGFBP1, HLA-G, LEP, APOH, SERPINE1, SERPINC1
3hypertension31.4NOS3, AGT, SERPINE1, LEP, F5, VCAM1
4hellp syndrome31.4APOH, SERPINE1, GSTP1, F5, SERPINC1
5mild pre-eclampsia31.2VCAM1, IGFBP1, SOD1
6placental insufficiency30.9FLT1, IGFBP1
7placental abruption30.9F5, SERPINC1
8thrombophilia30.8SERPINE1, SERPINC1, F5, APOH
9proteinuria30.7FLT1, HLA-G, AGT, NOS3, APOH
10essential hypertension30.6LEP, NOS3, HLA-G, SOD1, SERPINE1, AGT
11pregnancy loss30.6HLA-G, APOH, SERPINC1, F5
12diabetes mellitus30.6IGFBP1, SERPINE1, SOD1, SERPINC1, AGT, NOS3
13insulin resistance30.6SERPINE1, VCAM1, NOS3, IGFBP1, LEP, AGT
14antiphospholipid syndrome30.5APOH, SERPINC1, VCAM1, F5
15thrombocytopenia30.5SERPINC1, APOH, F5
16obesity30.5AGT, NOS3, MAOA, FLT1, SERPINE1, LEP
17bronchopulmonary dysplasia30.5FLT1, SOD1
18sepsis30.4F5, NOS3, SERPINE1, SERPINC1
19central retinal vein occlusion30.3F5, APOH
20lupus erythematosus30.3F5, APOH, SERPINC1
21hyperinsulinism30.3IGFBP1, LEP, SERPINE1
22vascular disease30.3SERPINC1, APOH
23portal vein thrombosis30.3F5, SERPINC1
24disseminated intravascular coagulation30.3SERPINC1, SERPINE1, F5
25retinal vein occlusion30.3APOH, F5, SERPINC1
26antithrombin iii deficiency30.3SERPINC1, APOH, F5
27polycystic ovary syndrome30.3IGFBP1, SERPINE1, LEP
28breast cancer30.3HLA-G, IGFBP1, SERPINE1, EPHX1, GSTP1, FLT1
29purpura30.3SERPINC1
30glucose intolerance30.2SERPINE1, IGFBP1, LEP
31type 1 diabetes mellitus30.1LEP, AGT, IGFBP1
32thromboembolism30.1SERPINC1, NOS3, APOH, F5, SERPINE1
33ischemia30.1FLT1, AGT, SOD1, NOS3
34diabetic retinopathy30.0IGFBP1, SOD1, FLT1, VCAM1, SERPINE1, AGT
35hyperglycemia30.0NOS3, SOD1, IGFBP1, AGT, VCAM1, LEP
36thrombophlebitis30.0APOH
37protein s deficiency30.0SERPINC1, APOH, SERPINE1, F5
38endometriosis29.9FLT1, HLA-G, IGFBP1
39infertility29.9LEP, IGFBP1, HLA-G
40adenoma29.9EPHX1, GSTP1, FLT1, IGFBP1, HLA-G
41hyperhomocysteinemia29.8NOS3, F5, VCAM1, SOD1, SERPINC1, SERPINE1
42myocardial infarction29.7F5, SERPINE1, IGFBP1, NOS3, AGT, SERPINC1
43atherosclerosis29.7SERPINE1, FLT1, LEP, AGT, NOS3, VCAM1
44endotheliitis11.0
45hypoxia10.6
46gestational diabetes10.6
47familial hypertension10.5
48cerebritis10.5
49blindness10.5
50retinitis10.5

Graphical network of the top 20 diseases related to Pre-Eclampsia:



Diseases related to pre-eclampsia

Symptoms for Pre-Eclampsia

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Sources:
47OMIM
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Symptoms by clinical synopsis from OMIM:

189800

Clinical features from OMIM:

189800,609404,609402,609403,614595

Drugs & Therapeutics for Pre-Eclampsia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Pre-Eclampsia

Search NIH Clinical Center for Pre-Eclampsia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Pre-Eclampsia

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Anatomical Context for Pre-Eclampsia

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Sources:
33MalaCards
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MalaCards organs/tissues related to Pre-Eclampsia:

33
Placenta, Endothelial, Liver, Kidney, Brain, Lung, Testes, Nk cells, T cells, Breast, Myeloid, Thyroid, Pancreas, Heart, B cells, Fetal lung, Whole blood, Monocytes, Ovary, Skin, Colon, Retina, Pituitary

Animal Models for Pre-Eclampsia or affiliated genes

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Sources:
37MGI
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Publications for Pre-Eclampsia

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Sources:
52PubMed
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Articles related to Pre-Eclampsia:

(show top 50)    (show all 1240)
idTitleAuthorsYear
1
A report from #BlueJC: Can measuring angiogenic factors help with predicting preterm pre-eclampsia in low-risk women? (24428457)
2014
2
Pre-eclampsia or chronic kidney disease? The flow hypothesis. (23314318)
2013
3
A case-control study of placental lesions associated with pre-eclampsia. (23200099)
2013
4
Aspirin for pre-eclampsia: beware of subgroup meta-analysis. (23610032)
2013
5
Development of maternal and neonatal composite outcomes for trials evaluating management of late-onset pre-eclampsia. (24303960)
2013
6
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
7
Uterine artery Doppler and sFlt-1/PlGF ratio: usefulness in diagnosis of pre-eclampsia. (23303638)
2013
8
Candidate gene study of genetic thrombophilic polymorphisms in pre-eclampsia and recurrent pregnancy loss in Sinhalese women. (22540831)
2012
9
Improving diagnosis and clinical management of pre-eclampsia. (22452158)
2012
10
Hemodynamic evaluation and anti-hypertensive schemes used in puerperal women following pre-eclampsia. (22561779)
2012
11
Unilateral focal renal artery stenosis complicated by early onset superimposed pre-eclampsia. (22663329)
2012
12
Contribution of PARP to endothelial dysfunction and hypertension in a rat model of pre-eclampsia. (22339234)
2012
13
Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia--a case-control study. (21534854)
2011
14
An unexpected tail of VEGF and PlGF in pre-eclampsia. (22103490)
2011
15
Fractional excretion of urea in pre-eclampsia: a clinical observation. (22057072)
2011
16
Aortic intima-media thickness and lipid profile in neonates born to mothers with pre-eclampsia: weak or strong relations? (21932615)
2011
17
A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes. (21340620)
2011
18
Plasminogen activator inhibitor-1 gene polymorphisms in pre-eclampsia. (21370208)
2011
19
A meta-analysis of eNOS and ACE gene polymorphisms and risk of pre-eclampsia in women. (21973132)
2011
20
Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. (21946915)
2011
21
PP13 as a marker of pre-eclampsia: A two platform comparison study. (21257081)
2011
22
Gene modification with integrin-linked kinase improves function of endothelial progenitor cells in pre-eclampsia in vitro. (21688303)
2011
23
Quantitative detection of the hypermethylated RASSF1A gene in maternal plasma of pre-eclampsia]. (20140873)
2010
24
Role of inflammatory cytokines and eNOS gene polymorphism in pathophysiology of pre-eclampsia. (20047583)
2010
25
Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction. (19108943)
2009
26
Profile of serum soluble endoglin in pregnant women with severe pre-eclampsia and eclampsia]. (19570416)
2009
27
Urgent termination of pregnancy in pre-eclampsia and panel of antiphospholipid antibodies. (19895376)
2009
28
Predictors and risk factors of pre-eclampsia. (18854808)
2008
29
The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell-free DNA and mRNA in normal pregnancy and pre-eclampsia. (18834630)
2008
30
Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia. (18226121)
2008
31
ADAM12s in maternal serum as a potential marker of pre-eclampsia. (18264967)
2008
32
Altered plasma neurokinin B levels in patients with pre-eclampsia. (17318561)
2007
33
Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes. (17167268)
2007
34
Overproduction of the follistatin-related gene protein in the placenta and maternal serum of women with pre-eclampsia. (17617189)
2007
35
Association between a functional dopamine D4 receptor promoter region polymorphism (-C521T) and pre-eclampsia: a family-based study. (16455620)
2006
36
Three mechanisms in the pathogenesis of pre-eclampsia suggested by over-represented transcription factor-binding sites detected with comparative promoter analysis. (16403800)
2006
37
Oxidative stress is closely related to clinical severity of pre-eclampsia. (16874398)
2006
38
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women. (15280126)
2004
39
Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. (14673478)
2004
40
Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study. (12653685)
2003
41
Soluble adhesion molecules: marker of pre-eclampsia and intrauterine growth restriction. (12422906)
2002
42
Oxidant stress in pre-eclampsia and essential hypertension. (12583464)
2002
43
Activation of the novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia. (11554693)
2001
44
Methylenetetrahydrofolate reductase polymorphisms are not a risk factor for pre-eclampsia/eclampsia in Australian women. (10965192)
2000
45
Neutrophil CD11B expression and neutrophil activation in pre-eclampsia. (9038589)
1997
46
Endothelin-1 stimulates the proliferation and invasion of first trimester trophoblastic cells in vitro--a possible role in the etiology of pre-eclampsia? (8952225)
1996
47
Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension. (8730885)
1996
48
The effect of severe pre-eclampsia on the pancreas: changes in the serum cationic trypsinogen and pancreatic amylase. (2447935)
1987
49
Severe pre-eclampsia of early onset. (6196074)
1983
50
The management of severe pre-eclampsia. (1050623)
1976

Variations for Pre-Eclampsia

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Expression for genes affiliated with Pre-Eclampsia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Pre-Eclampsia

Search GEO for disease gene expression data for Pre-Eclampsia.

Pathways for genes affiliated with Pre-Eclampsia

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Sources:
50PathCards, 5Cell Signaling Technology, 38NCBI BioSystems Database, 51PharmGKB, 55Reactome, 30KEGG, 60Thomson Reuters, 53QIAGEN, 54R&D Systems
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Pathways related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Angiogenesis38
10.3NOS3, FLT1
210.2GSTP1, SOD1
310.2MAOA, SOD1
410.1AGT, SERPINE1, LEP
510.1SERPINE1, LEP, IGFBP1
6
Show member pathways
10.0F5, SOD1, SERPINE1
7
Show member pathways
10.0EPHX1, MAOA, GSTP1
810.0EGLN2, FLT1, SERPINE1
9
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
10.0SERPINE1, SERPINC1, F5
10
Show member pathways
10.0SERPINE1, SERPINC1, F5
119.9EGLN2, NOS3, FLT1, SERPINE1
12
Show member pathways
9.8SERPINE1, SERPINC1, SOD1, F5, NOS3

Compounds for genes affiliated with Pre-Eclampsia

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Sources:
45Novoseek, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 11DrugBank, 29IUPHAR, 3BitterDB
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Compounds related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show top 50)    (show all 192)
idCompoundScoreTop Affiliating Genes
1apocynin45 6111.3VCAM1, SOD1, NOS3, AGT
2amlodipine45 51 24 1113.3NOS3, VCAM1, SERPINE1, AGT
3l-nmma4510.3LEP, VCAM1, SOD1, AGT, NOS3
4n(g)-nitro-l-arginine methyl ester4510.3LEP, SOD1, NOS3, SERPINE1, AGT
5tibolone4510.2LEP, SERPINE1, SERPINC1, F5
6ancrod4510.2F5, SERPINC1, SERPINE1
7uric acid45 2411.1LEP, F5, SOD1, SERPINE1, APOH
88-isoprostane4510.1APOH, SOD1, VCAM1, NOS3, SERPINE1, LEP
9sodium nitroprusside4510.1SERPINE1, VCAM1, NOS3, SOD1, LEP
10atorvastatin45 51 29 24 1114.1SERPINE1, F5, VCAM1, AGT, NOS3
11diphenyleneiodonium4510.1AGT, SOD1, NOS3, VCAM1
12p0034510.1FLT1, HLA-G, LEP, SERPINE1, EPHX1, APOH
13rosiglitazone29 45 51 24 1114.1NOS3, LEP, VCAM1, IGFBP1, SERPINE1
14p0024510.1F5, APOH, LEP, FLT1, IGFBP1
15raloxifene45 51 29 1113.0SERPINE1, SERPINC1, F5, NOS3
16folate4510.0GSTP1, F5, SERPINC1, APOH, NOS3, VCAM1
17methotrexate51 45 1112.0APOH, SERPINE1, HLA-G, LEP, GSTP1, NOS3
18simvastatin45 51 61 29 24 1115.0NOS3, AGT, F5, VCAM1, SERPINE1
19glutathion4510.0GSTP1, EPHX1, SOD1
20aspirin45 51 29 2413.0NOS3, APOH, SERPINE1, SERPINC1, GSTP1, F5
21tamoxifen45 51 29 1113.0IGFBP1, LEP, SERPINC1, VCAM1, F5, NOS3
22homocysteine45 2411.0APOH, SERPINE1, NOS3, F5, VCAM1, AGT
23genistein45 29 61 3 24 1115.0SERPINE1, NOS3, FLT1, VCAM1, AGT, GSTP1
24fenofibrate45 51 1112.0LEP, SERPINE1, VCAM1, NOS3
25epinephrine45 24 1112.0AGT, GSTP1, LEP, IGFBP1, MAOA, F5
26n acetylcysteine459.9VCAM1, AGT, GSTP1, LEP, SERPINC1, SOD1
27cyclophosphamide45 51 1111.9F5, NOS3, EPHX1, VCAM1, SERPINE1, APOH
28warfarin45 51 24 1112.9F5, EPHX1, SERPINC1, APOH
29lactate459.8IGFBP1, F5, GSTP1, HLA-G, APOH, SOD1
30phosphatidylinositol459.8AGT, NOS3, APOH, EPHX1, FLT1, IGFBP1
31fibrinogen459.8F5, IGFBP1, AGT, VCAM1, SERPINC1, APOH
32superoxide45 2410.8GSTP1, FLT1, NOS3, TAC3, EPHX1, VCAM1
33h2o2459.7LEP, FLT1, MAOA, NOS3, AGT, GSTP1
34dexamethasone45 51 29 1112.7AGT, MAOA, VCAM1, IGFBP1, LEP, SERPINE1
35progesterone45 29 61 24 1113.7IGFBP1, HLA-G, LEP, APOH, FLT1, F5
36ascorbic acid45 2410.7SERPINC1, SOD1, MAOA, GSTP1, F5, EGLN2
37testosterone45 61 24 1112.7SERPINE1, IGFBP1, F5, VCAM1, SERPINC1, MAOA
38heparin45 29 24 1112.7AGT, VCAM1, SERPINE1, IGFBP1, FLT1, SERPINC1
39cysteine459.6VCAM1, LEP, MAOA, SOD1, HLA-G, AGT
40nitric oxide45 24 1111.6SERPINE1, APOH, SOD1, FLT1, VCAM1, F5
41cholesterol45 29 24 1112.6FLT1, AGT, F5, EPHX1, HLA-G, VCAM1
42prostacyclin459.6NOS3, AGT, F5, VCAM1, FLT1, SOD1
43lipid459.6FLT1, APOH, LEP, SERPINE1, SOD1, AGT
44glycerol45 24 1111.5NOS3, GSTP1, SERPINC1, IGFBP1, LEP
45serine459.5FLT1, VCAM1, GSTP1, F5, NOS3, AGT
46oxygen45 2410.5AGT, IGFBP1, APOH, SOD1, FLT1, VCAM1
47arginine459.5VCAM1, SOD1, SERPINC1, APOH, IGFBP1, GSTP1
48creatinine459.4IGFBP1, FLT1, GSTP1, F5, AGT, SOD1
49estrogen459.1IGFBP1, LEP, APOH, SERPINE1, SERPINC1, FLT1
50vegf459.1AGT, HLA-G, EGLN2, NOS3, F5, IGFBP1

GO Terms for genes affiliated with Pre-Eclampsia

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16Gene Ontology
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Cellular components related to Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058869.2SERPINE1, SERPINC1, SOD1, FLT1, VCAM1, GSTP1
2extracellular regionGO:0055769.1AGT, IGFBP1, TAC3, F5, SOD1, SERPINC1
3extracellular spaceGO:0056158.7SOD1, GSTP1, F5, TAC3, AGT, FLT1

Biological processes related to Pre-Eclampsia according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1ovulation from ovarian follicleGO:00154210.5LEP, NOS3
2positive regulation of cytokine productionGO:00181910.4AGT, SOD1, LEP
3positive regulation of superoxide anion generationGO:03293010.4AGT, GSTP1, SOD1
4positive regulation of MAPK cascadeGO:04341010.4AGT, FLT1, LEP
5regulation of blood pressureGO:00821710.4LEP, SOD1, NOS3
6leukocyte tethering or rollingGO:05090110.4VCAM1, LEP
7negative regulation of fibrinolysisGO:05191810.3APOH, SERPINE1
8positive regulation of angiogenesisGO:04576610.3NOS3, FLT1, SERPINE1
9platelet degranulationGO:00257610.3F5, SOD1, SERPINE1
10negative regulation of endopeptidase activityGO:01095110.3SERPINE1, SERPINC1, AGT
11positive regulation of blood coagulationGO:03019410.3SERPINE1, APOH
12nitric oxide mediated signal transductionGO:00726310.3AGT, NOS3
13negative regulation of blood coagulationGO:03019510.2APOH, SERPINE1
14cellular response to vascular endothelial growth factor stimulusGO:03592410.1VCAM1, FLT1
15blood coagulationGO:00759610.1SERPINE1, SERPINC1, SOD1, F5, NOS3
16response to hypoxiaGO:00166610.0EGLN2, VCAM1, LEP
17negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.9SERPINE1, NOS3

Molecular functions related to Pre-Eclampsia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.1VCAM1, MAOA
2serine-type endopeptidase inhibitor activityGO:0048679.8AGT, SERPINC1, SERPINE1
3protein bindingGO:0055158.9AGT, APOH, SERPINE1, SERPINC1, SOD1, FLT1

Products for genes affiliated with Pre-Eclampsia

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Sources for Pre-Eclampsia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet