Search MalaCards:
MCID: PRC019

Precocious Puberty malady
9 drugs, 67 genes, 6 tissues, 528 related diseases, 18 phenotypes, 153 articles, clinical trials.

Summaries for Precocious Puberty

about this section
Sources:
22MalaCards
See all sources

Export this MalaCard
MalaCards: Precocious Puberty, also known as familial precocious puberty, is related to testotoxicosis and mccune albright syndrome. An important gene associated with Precocious Puberty is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Adenylate cyclase activating pathway and Regulation of CFTR gating (normal and CF). The drugs leuprolide and nafarelin acetate and the compounds pacap 1-38 and nkh 477 have been mentioned in the context of this disorder. Affiliated tissues include ovary, heart and t cells, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Aliases & Descriptions for Precocious Puberty

about this section
Sources:
7diseasecard, 30NIH Rare Diseases, 43UMLS
See all sources
precocious puberty 7 30 43
familial precocious puberty 30
idiopathic sexual precocity 30
sexual precocity 30

Related Diseases for Precocious Puberty

about this section
Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to precocious puberty by text searches and GeneDecks gene sharing:

(show top 50)    (show all 525)
idRelated DiseaseScoreTop Affiliating Genes
1testotoxicosis34.7LHCGR, CYP19A1
2mccune albright syndrome34.0GNAS, GH1, PRL
3precocious puberty, male32.8LHCGR, FSHR, CYP19A1, CYP21A2
4hypothalamic hamartomas32.0INS, GRM1, IGF1, GNRH1, CYP21A2, TGFA
5familial male-limited precocious puberty31.8KISS1, LHCGR, LEP, CGA, CGB5, FSHR
6x-linked adrenal hypoplasia congenita31.8GK, NR0B1, NR5A1
7obesity31.5GHRL, ADCY3, ADRB3
8germinoma31.1CGA, CGB, CGB5, CYP19A1, CYP21A2, PRL
9ovarian cyst30.7CGA, CGB5, GNAS, GNRH1, CYP19A1
10placental site trophoblastic tumor30.4CGA, CGB, CGB5
1121-hydroxylase deficiency30.4BRD2, GNRH1, HSD3B1, HSD3B2, SULT2A1, CYP3A4
12teratoma30.1CGA, CGB, CGB5, GH1, SST, KRT18
13polyembryoma30.0CGA, AFP
14acid-labile subunit30.0IGFALS, IGFBP3, IGF1, GH1, GHR
1511-beta-hydroxylase deficiency29.6REN, GH1, CYP21A2, SHBG
16hypothyroidism29.5CGA, FSHR, CALCA, SHBG, TSHR
17myelomeningocele29.2BGLAP, LEP, IGFBP3, IGF1, GNRH1, PRL
18sertoli-leydig cell tumor29.1FSHR, HSD3B1, ESR1, CYP19A1, NR5A1, AFP
19adrenal adenoma29.0REN, SULT2A1, CYP19A1, CYP21A2, NR0B1, NR5A1
20germ cell tumor28.9CGA, CGB, CGB5, IGFALS, IGFBP3, IGF1
21adrenal hypoplasia28.8REN, GNRH1, GK, ESR1, NR0B1, NR3C1
22glucocorticoid resistance28.5REN, NR3C1, PRL, POMC
23mediastinitis27.7CGA, CGB, CALCA, ESR1, SST, TSHR
24craniopharyngioma27.3BRD2, LEP, CGA, INS, IGF1, CALCA
25polycystic ovary syndrome27.0LHCGR, LEP, CGA, CGB5, FSHR, IRS1
26klinefelter's syndrome26.9KISS1, KISS1R, BRD2, LEP, CGA, CGB
27virilization26.8LHCGR, LEP, CGA, CGB5, FSHB, INS
28leydig cell tumor26.8BRD2, LHCGR, CGA, CGB, CGB5, FSHR
29hypogonadotropism26.7KISS1, KISS1R, BRD2, BGLAP, LHCGR, LEP
30diabetes insipidus26.6REN, CGA, CGB, INS, IGF1, GNRH1
31growth hormone deficiency26.4REN, BGLAP, LEP, INS, IGFBP3, IGF1
32choriocarcinoma26.3KISS1, KISS1R, LEP, CGA, CGB, CGB5
33short stature26.2REN, BGLAP, LEP, INS, IGFBP3, IGF1
34hypogonadism24.8KISS1, KISS1R, BRD2, BGLAP, LHCGR, LEP
35adrenal hyperplasia24.5REN, LEP, CGA, CGB, CGB5, INS
36coronary heart disease24.0BGLAP, LEP, IRS1, INS, IGFBP3, IGF1
37hyperandrogenism23.4REN, BRD2, LHCGR, LEP, CGA, CGB5
38cerebritis20.0REN, BLVRB, BGLAP, LEP, CGA, CGB5
39insulin resistance18.7REN, KISS1, BGLAP, LEP, CGA, CGB5
40neuronitis18.1REN, KISS1, KISS1R, BLVRB, LHCGR, LEP
41thyroiditis18.1REN, KISS1, KISS1R, BGLAP, LHCGR, LEP
42adenoma17.4REN, KISS1, KISS1R, BRD2, BGLAP, LHCGR
43testicular leydig cell tumor13.9CGB, CYP19A1, CYP21A2
44leydig cell adenoma13.8LHCGR, CGA, GNRH1
45adrenal rest tumor13.8CGB, CYP21A2, NR5A1
46extragonadal germ cell tumor13.7CGB, CGB5, AFP
47anorchia13.7CGA, CGB5, NR5A1
48male pseudohermaphroditism due to defective lh13.7LHCGR, CGB5, HSD3B2, NR0B1, NR5A1
49chondrodysplasia13.7ADCY1, ADCY3, ADCY6, ADCY8, ADCY2, ADCY4
50mature teratoma13.6CGA, CGB, AFP

Graphical network of the top 20 diseases related to precocious puberty:



Graphical network of diseases related to precocious puberty

Clinical Features for Precocious Puberty

about this section

Drugs & Therapeutics for Precocious Puberty

about this section
Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for precocious puberty

Drug clinical trials:

Search ClinicalTrials for precocious puberty

Search NIH Clinical Center for precocious puberty

Search CenterWatch for precocious puberty

Inferred drug relations via UMLS/NDF-RT:

43 28 gonadorelin, gonadorelin acetate, gonadorelin hydrochloride, leuprolide, leuprolide acetate, nafarelin, nafarelin acetate, tamoxifen, tamoxifen citrate

Genetic Tests for Precocious Puberty

about this section

Anatomical Context for Precocious Puberty

about this section
Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to precocious puberty:

22
Ovary, Heart, T cells, B cells, Pineal, Pituitary

Phenotypes for genes affiliated with Precocious Puberty

about this section
Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to precocious puberty:

25 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:000539710.4FSHR, KISS1R
2endocrine/exocrine gland phenotypeMP:00053799.2KISS1R, KISS1, BRD2, LHCGR, AFP, ADRB3
3liver/biliary system phenotypeMP:00053708.7GHRH, CYP19A1, BRD2, IRS1, INS, GK
4renal/urinary system phenotypeMP:00053678.1KISS1, LHCGR, INS, GNRHR, GNRH1, KISS1R
5reproductive system phenotypeMP:00053897.7REN, LHCGR, GH1, KISS1, KISS1R, AFP
6integument phenotypeMP:00107717.7GNRHR, GNRH1, GNAS, FSHR, KISS1R, CALCA
7muscle phenotypeMP:00053697.0ADCY6, REN, CYP19A1, NPY1R, TGFA, LEP
8normal phenotypeMP:00028736.9IGF1, INS, KISS1R, REN, ADCY3, NPY
9mortality/agingMP:00107686.8TSHR, NPY1R, ADCY3, ADCY7, BRD2, KISS1R
10digestive/alimentary phenotypeMP:00053816.7KISS1, LHCGR, INS, GNRH1, LEP, KISS1R
11skeleton phenotypeMP:00053906.7IGFALS, GRM1, INS, IRS1, IGF1, GNAS
12nervous system phenotypeMP:00036315.9CYP19A1, GHR, GHRH, GRM1, INS, FSHR
13cardiovascular system phenotypeMP:00053855.3REN, CALCA, GNAS, IGF1, INS, IRS1
14adipose tissue phenotypeMP:00053755.2ADRB3, GRM1, INS, IRS1, FSHR, LEP
15immune system phenotypeMP:00053874.8ADCY9, GNAS, IGF1, INS, IRS1, FSHR
16growth/size phenotypeMP:00053784.8FSHR, GNRH1, GNRHR, IRS1, ADCY3, ADCY8
17behavior/neurological phenotypeMP:00053864.5REN, KISS1R, GABRA1, ADCY7, ADCY5, ADRB3
18homeostasis/metabolism phenotypeMP:00053763.0GABRA1, AFP, ADCY5, ADRB3, ADCY8, ADCY6

Publications for genes affiliated with Precocious Puberty

about this section
Sources:
35PubMed
See all sources

Articles related to precocious puberty:

(show top 50)    (show all 153)
idTitleAuthorsYearAffiliating Genes
1Serum kisspeptin levels in Korean girls with central precocious puberty. (21738347)Rhie Y.J.... Kim H.S.2011KISS1
2An association study between the genetic polymorphism s within GnRHI, LHI^ and FSHI^ genes and central precocious puberty in Chinese gi rls. (20869425)Zhao Y.... Xiao J.2010FSHB, GHRH
3Subcutaneous gonadotropin-releasing hormone agonist ( triptorelin) test for diagnosing precocious puberty. (19690429)Poomthavorn P.... Mahachoklertwattana P.2009GNRH1
4Precocious puberty with hypothalamic hamartoma and no n classical form of congenital adrenal hyperplasia. Report of two cases. (19794382)Pasquino A.M.... Cappa M.2009CYP21A2
5Primary glucocorticoid resistance syndrome presenting as pseudo-precocious puberty and galactorrhea (19024330)Xiang S.L.... Liang J.Z.2008PRL
6Molecular analysis of the neuropeptide Y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism. (17140570)Freitas K.C.... Latronico A.C.2007NPY1R
7GNAS mutation detection is related to disease severity in girls with McCune-Albright syndrome and precocious puberty. (17982386)Wagoner H.A.... Hannon T.S.2007GNAS
8Central precocious puberty is associated with a high prevalence of organic disease (17184603)MartA-n DA-az M.J.... Argente Oliver J.2006GNRH1
9Gonadotropin-releasing hormone analog therapy for central precocious puberty and other childhood disorders affecting growth and puberty. (17002488)Lee P.A.... Houk C.P.2006GNRH1, GH1
10Familial precocious puberty -- a variant of norm or pathology? (16704862)Ziora K.... Dyduch A.2006CYP19A1
11Precocious puberty caused by hCG-producing germinoma involving the bilateral basal ganglia and cerebral white matter without 1ypical radiologic findings: case report (16768139)Sugiyama S.... Tominaga T.2006CGB5
12The gonadotrophins response to GnRH test is not a predictor of neurological lesion in girls with central precocious puberty. (16279361)Ng S.M.... Didi M.2005GNRH1
13Leptin changes in Taiwanese girls with central precocious puberty before and during the GnRH agonist treatment. (16640001)Su P.H.... Chen S.J.2005LEP, LSL
14Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome. (12199354)Roth C.... Albers N.2002CYP19A1
15The acid-labile subunit of human ternary insulin-like growth factor-binding protein complex in girls with central precocious puberty before and during gonadotropin-releasing hormone analog therapy. (12364447)Cisternino M.... Tato L.2002IGF1, IGFBP3, IGFALS
16Therapeutic potential of GnRH antagonists in the treatment of precocious puberty. (12225246)Roth C.2002GNRH1
17Activating mutations of the lutropin choriogonadotropin receptor in precocious puberty. (12408104)Shenker A.2002LHCGR
18Precocious puberty associated with growth hormone deficiency in a patient with craniopharyngioma: report of one case. (11550415)Chen Y.D.... Ho W.L.2001INS
19Aromatase p450 expression in a feminizing adrenal adenoma presenting as isosexual precocious puberty. (11158024)Phornphutkul C.... Goodwin G.2001CYP19A1
20Case study: sexual hyperactivity treated with psychostimulants in familial male precocious puberty. (11288780)Weissenberger A.A.... Zametkin A.J.2001LHCGR
21Precocious puberty in girls depending on choriogonadotropin - case reports and literature review (12818144)Starzyk J.... Dziatkowiak H.2001CYP19A1, CGA
22Gonadotropin releasing hormone-independent precocious puberty in a 5 year-old girl with suprasellar germ cell tumor secreting beta-h CG and alpha-fetoprotein. (11453531)Starzyk J.... Dziatkowiak H.2001CGA
23LHRH analogue and growth hormone did not improve the final height of a patient with juvenile hypothyroidism accompanied by precocious puberty. (10960339)Miyazaki R.... Kobayashi Y.2000GNRH1
24Substitution of M398T in the second transmembrane helix of the LH receptor in a patient with familial male-limited precocious puberty. (11200941)Ignacak M.... Trzeciak W.H.2000LHCGR
25Recent advances in the diagnosis and treatment of precocious puberty. (10838724)Diaz A.... Danon M.2000GNRH1
26Gonadotropin releasing hormone agonist treatment for central precocious puberty. (10592446)Carel J.C.... Chaussain J.L.1999GNRH1
27Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. (9920060)Feuillan P.P.... Cutler G.B.1999INS
28Use of aromatase inhibitors in precocious puberty. (10731123)Feuillan P.... Cutler G.B.1999CYP19A1
29The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. (9543124)Palmert M.R.... Boepple P.A.1998LEP, LSL
30Timing for discontinuation of treatment with a long-acting gonadotropin-releasing hormone analog in girls with central precocious puberty. TAP-144SR CPP Study Group. (9790269)Ohyama K.... Hibi I.1998GNRH1
31Gonadotrophin and prolactin secretory dynamics in girls with normal puberty, idiopathic precocious puberty and precocious puberty due to hypothalamic hamartoma. (9861328)Uriarte M.M.... Cutler G.B.1998PRL
32Leptin levels in children with central precocious puberty. (9661592)Palmert M.R.... Boepple P.A.1998LEP, LSL
33Primary intrasellar mixed germ-cell tumor with precocious puberty and diabetes insipidus. (9083701)Cho D.Y.... Ho W.L.1997CGA, AFP, CGB
34A missense (T577I) mutation in the luteinizing hormone receptor gene associated with familial male-limited precocious puberty. (8829636)Cocco S.... Moi P.1996LHCGR
35Treatment of central precocious puberty: comparison of urinary gonadotropin excretion and gonadotropin-releasing hormone (GnRH) stimulation tests in monitoring GnRH analog therapy. (8636332)Witchel S.F.... Lee P.A.1996GNRH1
36Heterogeneity of activating mutations of the human luteinizing hormone receptor in male-limited precocious puberty. (8812739)Laue L.... Chan W.Y.1996LHCGR
37A missense mutation in the second transmembrane segment of the luteinizing hormone receptor causes familial male-limited precocious puberty. (7593421)Kraaij R.... Themmen A.P.1995LHCGR
38Bone mineral content in girls with precocious puberty treated with gonadotropin-releasing hormone analog. (8629454)Verrotti A.... Morgese G.1995CALCA, GNRH1
39Precocious puberty in a girl with an hCG-secreting suprasellar immature teratoma. Case report. (7931595)Kitanaka C.... Hibi I.1994CGA
40True precocious puberty associated with phenylketonuria. (7735376)BA1yA1kgebiz B.... BA1y ukgebiz A.1994GNRH1
41GH and GHBP activity and not IGF-1 and its receptor activity express growth velocity reduction during treatment of central precocious puberty by a superactive GNRH analogue. (8045738)Eshet R.... Laron Z.1994IGF1, BLVRB
42Diagnosis and treatment of central precocious puberty--can final height be improved? German/Dutch Central Precocious Puberty Study Group. (8088698)Sippell W.G.1994GNRH1
43The effect of luteinizing hormone-releasing hormone a nalog for central precocious puberty on growth hormone (GH) and GH-binding prot ein. (8126139)Dimartino-Nardi J.... Saenger P.1994GHR
44Comparison of complete and incomplete suppression of pituitary-gonadal activity in girls with central precocious puberty: influence on growth and predicted final height. The German-Dutch Precocious Puberty Study Group. (8262471)Partsch C.J.... Drop S.L.1993GNRH1
45Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty. (8281137)Kremer H.... Brunner H.G.1993LHCGR
46Effect of cyproterone acetate on active and inactive renin secretion in patients with precocious puberty and genetic short stature. (1840421)Ohyama K.... Kato K.1991REN
47Bone loss during gonadotropin-releasing hormone agonist treatment in girls with true precocious puberty is not due to an impairment of calcitonin secretion. (1830057)Saggese G.... Cinquanta L.1991CALCA
48Suppression of the pituitary-gonadal axis in children with central precocious puberty: effects on growth, growth hormone, insulin-like growth factor-I, and prolactin secretion. (1909701)Sklar C.A.... David R.1991IGF1, PRL, GH1
49Analysis of gonadotropin-releasing hormone gene structure in families with familial central precocious puberty and idiopathic hypogonadotropic hypogonadism. (2186053)Nakayama Y.... Radovick S.1990GNRH1
50Treatment of children with central precocious puberty by a slow-release gonadotropin-releasing hormone agonist. (2138079)Oostdijk W.... Schultheiss H.1990GNRH1

Expression for genes affiliated with Precocious Puberty

about this section
Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Precocious Puberty

Pathways for genes affiliated with Precocious Puberty

about this section
Sources:
38Reactome, 41Thomson Reuters, 10EMD Millipore, 34PharmGKB, 20KEGG, 36QIAGEN
See all sources

Pathways related to precocious puberty according to GeneDecks:

(show top 50)    (show all 93)
idPathwayScoreTop Affiliating Genes
1Adenylate cyclase activating pathway3810.5ADCY7, ADCY5, ADCY4, ADCY2, ADCY8, ADCY6
2Regulation of CFTR gating (normal and CF)4110.5ADCY7, ADCY5, ADCY4, ADCY2, ADCY8, ADCY6
3Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling4110.4ADCY1, ADCY6, ADCY8, ADCY2, ADCY4, ADCY5
4Neurophysiological process_PGE2-induced pain processing4110.3ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
5Neurophysiological process PGE2-induced pain processing1010.3ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
6Proton Pump Inhibitor Pathway, Pharmacodynamics3410.3ADCY4, ADCY2, ADCY8, ADCY6, ADCY3, ADCY1
7Beta-agonist/Beta-blocker Pathway, Pharmacodynamics3410.2ADCY1, ADCY3, ADCY6, ADCY8, ADCY2, ADCY5
8Development Endothelin-1/EDNRA signaling1010.2ADCY6, ADCY1, GNAS, ADCY8, ADCY2, ADCY4
9Development_Endothelin-1/EDNRA signaling4110.2GNAS, ADCY1, ADCY9, ADCY5, ADCY4, ADCY2
10Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation4110.2ADCY5, ADCY9, ADCY8, ADCY2, ADCY7, ADCY4
11Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation1010.2ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
12Signal transduction_cAMP signaling4110.2ADCY8, GNAS, ADCY1, ADCY3, ADCY7, ADCY5
13Signal transduction cAMP signaling1010.2ADCY4, ADCY5, ADCY7, ADCY6, ADCY9, ADCY2
14Development Beta-adrenergic receptors signaling via cAMP1010.2ADCY4, ADCY2, ADRB3, ADCY8, ADCY6, ADCY3
15Development_Beta-adrenergic receptors signaling via cAMP4110.2ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADRB3
16Signal transduction PKA signaling1010.2ADCY1, GNAS, ADCY3, ADCY8, ADCY2, ADCY4
17Beta-2 adrenergic-dependent CFTR expression4110.2GNAS, ADCY9, ADCY7, ADCY5, ADCY4, ADCY2
18Signal transduction_PKA signaling4110.1ADCY6, ADCY8, ADCY1, ADCY3, ADCY2, ADCY4
19Development Beta-adrenergic receptors regulation of ERK1010.1ADCY8, ADRB3, ADCY2, ADCY4, ADCY6, ADCY7
20Development_Beta-adrenergic receptors regulation of ERK4110.1GNAS, ADCY1, ADCY9, ADCY3, ADCY6, ADCY8
21Regulation of CFTR activity (norm and CF)4110.1ADCY5, ADCY9, ADCY7, ADCY4, ADCY2, ADCY8
22Salivary secretion2010.1GNAS, ADRB3, ADCY1, ADCY9, ADCY7, ADCY5
23Pancreatic secretion2010.1ADCY4, ADCY2, ADCY8, ADCY3, ADCY1, GNAS
24Adenylate cyclase-activating neuropeptides1010.1ADCY4, ADCY2, ADCY8, ADCY6, ADCY3, ADCY1
25Relaxin Pathway3610.1ADCY1, ADCY8, ADCY6, ADCY3, ADCY7, ADCY9
26Vascular smooth muscle contraction2010.1ADCY7, ADCY9, ADCY4, ADCY5, ADCY2, ADCY8
27Dilated cardiomyopathy2010.1GNAS, ADCY7, ADCY5, ADCY4, ADCY8, ADCY6
28G-AlphaI Signaling3610.0ADCY7, ADCY9, ADCY1, ADCY5, ADCY4, ADCY8
29Gastric acid secretion209.9ADCY7, ADCY5, ADCY4, ADCY2, ADCY8, ADCY6
30Hedgehog Signaling in Mammals369.9ADCY7, ADCY4, ADCY9, ADCY3, ADCY5, ADCY6
31Gap junction209.9ADCY1, ADCY3, ADCY6, ADCY8, ADCY2, ADCY4
32Bile secretion209.9ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
33Glutamatergic synapse209.9ADCY5, ADCY9, ADCY2, GNAS, ADCY1, ADCY3
34GnRH Signaling369.8CGA, FSHB, GNRH1, GNRHR, ADCY1, ADCY3
35GnRH signaling pathway209.8GNRH1, FSHB, CGA, GNRHR, ADCY1, ADCY9
36Development_Role of Activin A in cell differentiation and proliferation419.7LHCGR, CGA, ADCY9, ADCY7, ADCY5, ADCY4
37Development Role of Activin A in cell differentiation and proliferation109.7ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
38Breast Cancer Regulation by Stathmin1369.7ADCY3, ADCY6, ADCY8, ADCY2, ADCY4, ADCY5
39Melanogenesis209.6POMC, ADCY1, ADCY3, ADCY6, ADCY9, ADCY2
40Progesterone-mediated oocyte maturation209.6ADCY7, ADCY4, ADCY9, ADCY1, ADCY2, ADCY5
41Calcium signaling pathway209.6ADCY9, ADCY7, ADCY4, ADCY2, ADRB3, ADCY8
42Activation of PKC through GPCR369.5ADCY4, ADCY2, GNRH1, ADCY5, ADCY8, ADCY6
43Oocyte meiosis209.4ADCY1, INS, IGF1, ADCY9, ADCY7, ADCY5
44Activation of PKA through GPCR369.3ADCY6, ADCY5, ADCY4, ADCY2, ADCY7, ADCY9
45Activation of cAMP-Dependent PKA369.1IGF1, ADCY9, ADCY7, ADCY5, ADCY4, ADRB3
46Phospholipase-C Pathway369.1ADCY2, ADCY5, ADCY7, ADCY9, ADCY3, ADCY1
47eNOS Signaling369.0ADCY8, ADCY9, ADCY7, ADCY4, ADCY5, IGF1
48cAMP Pathway368.7GH1, GNRH1, ADCY5, TGFA, ADCY1, ADCY3
49ERK Signaling368.7ADCY5, IGF1, GNRH1, ESR1, GH1, GHRH
50Neuroactive ligand-receptor interaction208.2GABRA1, ADRB3, NPY1R, PRL, TSHR, NR3C1

Compounds for genes affiliated with Precocious Puberty

about this section
Sources:
42Tocris Bioscience, 32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB
See all sources

Compounds related to precocious puberty according to GeneDecks:

(show top 50)    (show all 330)
idCompoundScoreTop Affiliating Genes
1pacap 1-3842 10.4ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
2nkh 47742 10.4ADCY6, ADCY3, ADCY1, ADCY8, ADCY2, ADCY4
3bpipp42 10.4ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
4glucose32 10.3KISS1, BLVRB, KRT18, IGFALS, CGB
5sq 2253632 42 11.3ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
6isoproterenol32 9 9 11.7ADCY1, SST, GH1, GNRH1, GNAS, CGB5
7goserelin32 9 9 11.5CGA, LHCGR, GNRH1, GNRHR, ESR1, LSL
8ghrp32 9.3PRL, SST, GHRL, GHRH, GHR, GH1
9c-peptide32 9.3SHBG, CYP21A2, GHRL, GHR, IRS1, LEP
10cabergoline32 9 9 11.1PRL, SST, CYP3A4, GHR, GH1, GNRH1
11buserelin32 9 9 11.1LHCGR, CGA, CGB5, FSHB, PRL, SST
12progestin32 9.1SHBG, NR3C1, CYP19A1, GNRH1, CGB5, CGA
13bromocriptine32 9 9 11.0POMC, PRL, SST, CYP3A4, GHRH, GH1
14hexarelin32 8.7POMC, PRL, SST, GHRL, GHRH, GHR
15cyclic amp32 18 9.2ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADRB3
16raloxifene32 9 9 10.0CYP3A4, GH1, ESR1, CALCA, GNRHR, GNRH1
17triiodothyronine32 8.0POMC, PRL, TSHR, LSL, SHBG, SULT2A1
18clomiphene citrate32 7.8FSHB, CGB5, CGB, CGA, INS, AFP
19naloxone32 34 9 9 10.7GHRL, GHRH, GH1, ESR1, GNRH1, CGB5
20mifepristone32 42 9 9 10.6AFP, CGA, POMC, PRL, SHBG, NR3C1
21estrone32 9 18 9 10.5ESR1, GNRH1, IGF1, IGFBP3, IRS1, CGB5
22metformin32 34 9 9 10.4POMC, LSL, SHBG, CYP19A1, GHRL, GH1
23progesterone32 42 9 18 9 11.4AFP, ADCY1, GNRHR, GNRH1, GNAS, FSHR
24ribonucleic acid32 7.4GHRL, GHRH, GHR, GH1, GNRHR, GNRH1
25corticosterone32 18 8.2GHRL, GH1, CALCA, CGB5, LEP, LHCGR
26clonidine32 9 9 9.0GH1, CALCA, IGF1, IGFBP3, CGA, LEP
27octreotide32 42 9 9 10.0NPY, POMC, PRL, LSL, KRT18, SST
28dehydroepiandrosterone sulfate32 7.0IGF1, IGFBP3, INS, CGB5, CGA, LEP
29creatinine32 6.9KRT18, GHRL, GHR, GH1, GK, IGF1
30vitamin d32 6.9SULT2A1, GHRL, GHRH, GHR, GH1, ESR1
31dihydrotestosterone32 9 18 9 9.9IGF1, IGFBP3, CGB5, CGA, LEP, BGLAP
32dhea32 6.7POMC, PRL, LSL, SHBG, NR5A1, LEP
33tamoxifen32 34 9 9 9.6GH1, ESR1, GNRHR, GNRH1, IGF1, IGFBP3
34dopamine32 9 18 9 9.6GNRHR, GNRH1, GNAS, GRM1, IRS1, CGB5
35epinephrine32 9 18 9 9.5NPY, REN, LEP, POMC, TGFA, LSL
36forskolin32 42 9 9 9.5ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
37testosterone32 9 18 9 9.3PRL, TGFA, LSL, SHBG, KRT18, NR5A1
38adenylate32 6.3SHBG, NR5A1, SST, GHRL, GHRH, GH1
39alanine32 6.0ADRB3, NPY, POMC, TGFA, TSHR, LSL
40estradiol32 9 18 9 9.0POMC, CGB5, CGB, CGA, LHCGR, BLVRB
41gnrh32 5.9POMC, TGFA, LSL, SHBG, NR5A1, NR0B1
42androstenedione32 18 6.9POMC, PRL, LSL, SHBG, CYP21A2, CYP19A1
43steroid32 5.9AFP, POMC, PRL, TGFA, GNRH1, GNAS
44norepinephrine32 9 18 9 8.6ADRB3, NPY, POMC, PRL, TGFA, LSL
45hydrocortisone32 9 9 7.5CYP21A2, CYP19A1, CYP3A4, GHRL, GH1, CALCA
46thyroxine32 18 6.3REN, GHRH, GHR, GH1, CALCA, GNRH1
47acth32 4.8ADCY1, NPY, POMC, PRL, TSHR, LSL
48dexamethasone32 42 34 9 9 8.1NR0B1, CGB5, LEP, BGLAP, REN, IRS1
49arginine32 3.9ADRB3, ADCY1, NPY, POMC, GNAS, IGF1
50estrogen32 2.8SULT2A1, FSHR, FSHB, CGB5, CGB, CGA

GO Terms for genes affiliated with Precocious Puberty

about this section
Sources:
12Gene Ontology
See all sources

Cellular components related to precocious puberty according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:0160208.3NR3C1, ADCY6, ADCY8, ADCY2, NR0B1, CYP19A1
2plasma membraneGO:0058866.8ADCY1, ADCY3, ADCY6, ADCY8, ADRB3, ADCY2
3extracellular regionGO:0055765.4IGF1, NPY, POMC, IGFALS, INS, FSHB
4extracellular spaceGO:0056155.4AFP, IGF1, IGFBP3, IGFALS, INS, LEP

Biological processes related to precocious puberty according to GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1mineralocorticoid biosynthetic processGO:00670510.6CYP21A2, HSD3B2, HSD3B1
2cAMP biosynthetic processGO:00617110.5GNAS, ADCY1, ADCY6, ADCY2, ADCY4
3steroid biosynthetic processGO:00669410.5NR0B1, CYP19A1, HSD3B2, HSD3B1
4glucocorticoid biosynthetic processGO:00670410.5HSD3B1, HSD3B2, CYP21A2
5adenylate cyclase-modulating G-protein coupled receptor signaling pathwayGO:00718810.5ADCY4, LHCGR, ADCY2, ADRB3
6activation of protein kinase A activityGO:03419910.5ADCY1, ADCY9, ADCY7, ADCY5, ADCY4, ADCY2
7activation of phospholipase C activityGO:00720210.5ADCY3, ADCY9, ADCY7, ADCY5, ADCY4, ADCY1
8fibroblast growth factor receptor signaling pathwayGO:00854310.4ADCY8, ADCY2, ADCY6, ADCY5, ADCY9, ADCY7
9intracellular signal transductionGO:03555610.4ADCY5, ADCY1, ADCY3, ADCY6, ADCY8, ADCY2
10adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.4ADCY1, ADCY3, ADCY6, ADCY8, ADCY2, ADCY4
11gonad developmentGO:00840610.4CGA, NR0B1, FSHR
12female gamete generationGO:00729210.3FSHB, FSHR
13cellular response to glucagon stimulusGO:07137710.3ADCY3, ADCY1, GNAS, ADCY9, ADCY6, ADCY7
14water transportGO:00683310.3ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY6
15positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.3IGF1, GH1, IGFBP3, GHRH
16G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.2NPY1R, NPY, TSHR, LHCGR, ADRB3
17activation of adenylate cyclase activityGO:00719010.2CALCA, GNAS, ADRB3, LHCGR
18nerve growth factor receptor signaling pathwayGO:04801110.2ADCY6, ADCY8, ADCY2, ADCY1, IRS1, ADCY7
19steroid metabolic processGO:00820210.2CYP3A4, CYP21A2, HSD3B2, HSD3B1, SULT2A1, CYP19A1
20transmembrane transportGO:05508510.1GABRA1, ADCY5, ADCY8, ADCY6, ADCY7, ADCY2
21regulation of multicellular organism growthGO:04001410.1NPY1R, IGF1, PRL, GHR
22adrenal gland developmentGO:03032510.1NR0B1, NR3C1, CYP19A1, NR5A1
23male gonad developmentGO:00858410.1REN, LHCGR, FSHR, CYP19A1, NR5A1, NR0B1
24epidermal growth factor receptor signaling pathwayGO:00717310.0ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
25JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.0PRL, GHR, IRS1, GH1
26adult feeding behaviorGO:00834310.0NPY, GHRL, LEP
27positive regulation of multicellular organism growthGO:04001810.0TSHR, GH1, GHRH, GHR, GHRL
28female pregnancyGO:0075659.9FSHB, LEP, GNAS, GNRH1, PRL
29insulin-like growth factor receptor signaling pathwayGO:0480099.9IRS1, IGF1, GHR
30peptide hormone processingGO:0164869.9FSHB, POMC, CGB, CGA
31hormone-mediated signaling pathwayGO:0097559.9GHR, GHRL, LHCGR, REN
32adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.8ADCY9, ADCY7, FSHR, CALCA, GHRH, TSHR
33response to estradiol stimulusGO:0323559.7ESR1, NPY1R, CYP19A1, GHR, GH1
34positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IGF1, GH1, GHR
35synaptic transmissionGO:0072689.5ADCY5, ADCY3, ADCY6, ADCY1, ADCY8, ADCY2
36positive regulation of insulin receptor signaling pathwayGO:0466289.4LEP, IRS1, INS
37positive regulation of glycogen biosynthetic processGO:0457259.3INS, IRS1, IGF1
38positive regulation of MAPK cascadeGO:0434109.2LEP, INS, IGFBP3, IGF1, ADRB3
39regulation of blood pressureGO:0082179.2NPY1R, LEP, REN, CALCA, POMC
40energy reserve metabolic processGO:0061129.1LEP, ADCY9, ADCY7, ADCY5, ADCY4, INS
41positive regulation of cell migrationGO:0303359.0TRIP6, CGA, FSHB, IRS1, INS
42response to drugGO:0424938.7REN, ADCY1, TGFA, SST, LHCGR, BGLAP
43positive regulation of cell proliferationGO:0082848.6LEP, FSHB, IRS1, CGA, INS, IGF1
44G-protein coupled receptor signaling pathwayGO:0071868.5KISS1, GNRHR, TSHR, SST, INS, GRM1
45cell-cell signalingGO:0072678.2GHRH, SST, CALCA, GNRH1, INS, CGB
46signal transductionGO:0071657.8ADCY6, ADCY1, POMC, ELK3, ADCY3, NR3C1
47small molecule metabolic processGO:0442817.7HSD3B2, CYP19A1, CYP21A2, ADCY4, ADCY2, ADCY8

Molecular functions related to precocious puberty according to GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1calcium- and calmodulin-responsive adenylate cyclase activityGO:00829410.3ADCY5, ADCY2, ADCY6, ADCY1, ADCY8
2adenylate cyclase activityGO:00401610.1GNAS, ADCY3, ADCY6, ADCY8, ADCY2, ADCY4
3growth hormone-releasing hormone activityGO:01660810.1GHRL, GHRH
4metal ion bindingGO:0468729.1ADCY9, ADCY7, ADCY5, ADCY4, ADCY2, ADCY8
5steroid bindingGO:0054969.0CYP3A4, ESR1, NR3C1, CYP21A2
6insulin-like growth factor receptor bindingGO:0051598.8REN, IRS1, IGF1, INS
7hormone activityGO:0051797.4CGA, CGB, FSHB, INS, IGF1, GNRH1

Sources for Precocious Puberty

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z