MCID: PRC019
MIFTS: 60

Precocious Puberty malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases categories
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Summaries for Precocious Puberty

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NIH Rare Diseases:42 Precocious puberty is when a person's sexual and physical traits develop and mature earlier than normal. normal puberty typically begins between ages 10 and 14 for girls, and ages 12 and 16 for boys. the start of puberty depends on various factors such as family history, nutrition and gender. the cause of precocious puberty is not always known. some cases of precocious puberty are due to conditions that cause changes in the body's release of hormones. treatment involves medications that can stop the release of sexual hormones. last updated: 12/21/2012

MalaCards based summary: Precocious Puberty, also known as cryptogenic sexual precocity, is related to adenoma and hypogonadism. An important gene associated with Precocious Puberty is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Calcium signaling pathway and Ras signaling pathway. The drugs gonadorelin and gonadorelin acetate and the compounds forskolin and adenylate have been mentioned in the context of this disorder. Affiliated tissues include pituitary, brain and testes, and related mouse phenotypes are taste/olfaction and behavior/neurological.

Wikipedia:65 In medicine, precocious puberty is puberty occurring at an unusually early age. In most of these... more...

Aliases & Classifications for Precocious Puberty

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Sources:
42NIH Rare Diseases, 22GTR, 62UMLS, 44Novoseek, 25ICD10
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Precocious Puberty, Aliases & Descriptions:

Name: Precocious Puberty 42 22 62
Cryptogenic Sexual Precocity 62
Familial Precocious Puberty 42
 
Idiopathic Sexual Precocity 42
Puberty Precocious 44
Sexual Precocity 42


Classifications:



External Ids:

ICD1025 E30.1

Related Diseases for Precocious Puberty

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Diseases in the Precocious Puberty family:

Central Precocious Puberty Precocious Puberty, Central, 2
Precocious Puberty, Central, 1

Diseases related to Precocious Puberty via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.0LHCGR
2hypogonadism30.8KISS1R, LHCGR
3central precocious puberty11.4
4hypothalamic hamartomas10.9
5idiopathic central precocious puberty10.9
6mccune albright syndrome10.8
7familial male-limited precocious puberty10.8
8hypothyroidism10.7
9spastic paraplegia with precocious puberty10.6
10testotoxicosis10.6
11precocious puberty, male10.6
12precocious puberty, central, 110.6
13obesity10.5
14germinoma10.5
15growth hormone deficiency10.5
16hyperandrogenism10.5
17precocious puberty, central, 210.5
18polycystic ovary syndrome10.5
19congenital adrenal hyperplasia10.5
20vaginitis10.5
21teratoma10.5
22klinefelter's syndrome10.4
23neurofibromatosis10.4
24leydig cell tumor10.4
25turner syndrome10.4
26x-linked adrenal hypoplasia congenita10.4
27germ cell tumors10.4
28hypogonadotropism10.3
29prader-willi syndrome10.3
30arachnoiditis10.3
31empty sella syndrome10.3
32astrocytoma10.3
33craniopharyngioma10.3
34hepatoblastoma10.3
35histiocytosis10.3
36mediastinitis10.3
37arachnoid cysts10.3
38pineal cyst10.3
39secondary central precocious puberty10.3
40x-linked intellectual disability - precocious puberty - obesity10.3
4121-hydroxylase deficiency10.3
42diabetes mellitus10.3
43hydrocephalus10.3
44hypertension10.3
45phenylketonuria10.3
46langerhans-cell histiocytosis10.3
47tuberous sclerosis10.3
48proteus syndrome10.3
49congenital hypothyroidism10.3
50hyperprolactinemia10.3

Graphical network of the top 20 diseases related to Precocious Puberty:



Diseases related to precocious puberty

Symptoms for Precocious Puberty

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Drugs & Therapeutics for Precocious Puberty

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Drug clinical trials:

Search ClinicalTrials for Precocious Puberty

Search NIH Clinical Center for Precocious Puberty

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Precocious Puberty

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Genetic tests related to Precocious Puberty:

id Genetic test Affiliating Genes
1 Precocious Puberty22

Anatomical Context for Precocious Puberty

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MalaCards organs/tissues related to Precocious Puberty:

32
Pituitary, Brain, Testes, Bone, Ovary, Pineal, Thyroid, Testis, Spinal cord, Heart, Pancreas, Breast, Skin, Prostate, Hypothalamus

Animal Models for Precocious Puberty or affiliated genes

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MGI Mouse Phenotypes related to Precocious Puberty:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.2ADCY8, ADCY3
2MP:00053867.9ADCY6, LHCGR, ADCY5, ADCY8, KISS1R
3MP:00053767.7KISS1R, LHCGR, ADCY5, ADCY8, ADCY6

Publications for Precocious Puberty

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Articles related to Precocious Puberty:

(show top 50)    (show all 758)
idTitleAuthorsYear
1
Precocious puberty. (25144596)
2014
2
A Pediatrician's Guide to Central Precocious Puberty. (25022947)
2014
3
The Usefulness of the Leuprolide Stimulation Test as a Diagnostic Method of Idiopathic Central Precocious Puberty in Girls. (25295414)
2014
4
Surgical treatment of hypothalamic hamartoma causing central precocious puberty: long-term follow-up. (23746126)
2013
5
A case of an adoptive girl with precocious puberty: the problem of age estimation. (23830875)
2013
6
Peripheral precocious puberty due to inadvertent exposure to testosterone: case report and review of the literature. (23426834)
2012
7
Fulvestrant treatment of precocious puberty in girls with McCune-Albright syndrome. (22999294)
2012
8
Bone mineral density and body composition in girls with idiopathic central precocious puberty before and after treatment with a gonadotropin-releasing hormone agonist. (22760897)
2012
9
Case of juvenile localized scleroderma with joint sclerosis and SjAPgren's syndrome in a child with precocious puberty. (21658114)
2011
10
Unique concurrent appearance of two rare conditions in a young girl: central precocious puberty due to hypothalamic hamartoma and uncommon type of diabetes. (22145483)
2011
11
Peripheral precocious puberty in a 4-month-old girl: role of pesticides? (21306193)
2011
12
Allopregnanolone levels decrease after gonadotropin-releasing hormone analog stimulation test in girls with central precocious puberty. (20530984)
2011
13
Insight: prolonged vaginal bleeding during central precocious puberty therapy with a long-acting gonadotropin-releasing hormone agonist: a proposed mechanism and management plan. (21872518)
2011
14
Precocious puberty and pineal cyst--an uncommon association. (20228436)
2010
15
Effect of treatment with cyproterone acetate on uterine bleeding at the beginning of GnRH analogue therapy in girls with idiopathic central precocious puberty. (20389110)
2010
16
Early hyperandrogenism affects the development of hippocampal function: preliminary evidence from a functional magnetic resonance imaging study of boys with familial male precocious puberty. (19232022)
2009
17
Precocious puberty in a 7-year-old boy: a novel case. (19525149)
2009
18
Relationship of plasma ghrelin and adenohypophyseal hormone levels in female precocious puberty]. (18925720)
2008
19
Precocious puberty in a girl with floating-harbor syndrome. (18341094)
2007
20
Predictive factors for organic central precocious puberty and utility of simplified gonadotropin-releasing hormone tests. (18045276)
2007
21
An infant case of macroprolactinemia with transient idiopathic central precocious puberty. (17785914)
2007
22
Central precocious puberty is associated with a high prevalence of organic disease]. (17184603)
2006
23
Gonadotropin-releasing hormone analog therapy for central precocious puberty and other childhood disorders affecting growth and puberty. (17002488)
2006
24
Weight evolution in girls treated for idiopathic central precocious puberty with GnRH analogues. (17220061)
2006
25
Treatment of central precocious puberty. (16634688)
2006
26
Female precocious puberty, obesity and polycystic-like ovaries. (16254911)
2005
27
Basal ganglion hamartoma in a patient presenting with precocious puberty. (18095104)
2005
28
Tuberous sclerosis with hypothyroidism and precocious puberty. (15080418)
2004
29
Quantitative calcaneal ultrasound parameters and bone mineral density at final height in girls treated with depot gonadotrophin-releasing hormone agonist for central precocious puberty or idiopathic short stature. (13680381)
2003
30
Height prognosis in girls with central precocious puberty treated with GnRH analogues. (11940039)
2002
31
Ovarian and uterine findings in pelvic sonography: comparison between prepubertal girls, girls with isolated thelarche, and girls with central precocious puberty. (12418765)
2002
32
CNS germinoma in a boy with simple virilizing 21-hydroxylase deficiency and precocious puberty. (11926207)
2002
33
Long-term suppression of pituitary-gonadal function with three-month depot of leuprorelin acetate in a girl with central precocious puberty. (12446994)
2002
34
New thoughts on female precocious puberty. (11308042)
2001
35
Adrenocorticotropin-dependent precocious puberty of testicular origin in a boy with X-linked adrenal hypoplasia congenita due to a novel mutation in the DAX1 gene. (11549627)
2001
36
Age of puberty among girls and the diagnosis of precocious puberty. (11403073)
2001
37
Gonadotropin-independent precocious puberty due to luteinizing hormone receptor mutations in Brazilian boys: a novel constitutively activating mutation in the first transmembrane helix. (11134146)
2000
38
Substitution of M398T in the second transmembrane helix of the LH receptor in a patient with familial male-limited precocious puberty. (11200941)
2000
39
Prospective assessment of pituitary size and shape on MR imaging after suppressive hormonal therapy in central precocious puberty. (10929361)
2000
40
LHRH analogue and growth hormone did not improve the final height of a patient with juvenile hypothyroidism accompanied by precocious puberty. (10960339)
2000
41
Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. (9920060)
1999
42
Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. (10599723)
1999
43
Gonadotropin releasing hormone agonist treatment for central precocious puberty. (10592446)
1999
44
Combined treatment with gonadotropin-releasing hormone analog and growth hormone in central precocious puberty. (8772556)
1996
45
A case of male-limited precocious puberty caused by a point mutation in the second transmembrane domain of the luteinizing hormone choriogonadotropin receptor gene. (8607787)
1996
46
Precocious puberty in a case with probable Angelman syndrome. (7943614)
1994
47
Precocious puberty in a child with unilateral Leydig cell tumor of the testis following orchiopexy. (8105109)
1993
48
Predictive factors for the effect of gonadotrophin releasing hormone analogue therapy on the height of girls with idiopathic central precocious puberty. (1425790)
1992
49
Treatment of children with central precocious puberty by a slow-release gonadotropin-releasing hormone agonist. (2138079)
1990
50
Luteinizing hormone-releasing hormone analogue (Buserelin) treatment for central precocious puberty: a multi-centre trial. (2109996)
1990

Variations for Precocious Puberty

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Expression for genes affiliated with Precocious Puberty

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Expression patterns in normal tissues for genes affiliated with Precocious Puberty

Search GEO for disease gene expression data for Precocious Puberty.

Pathways for genes affiliated with Precocious Puberty

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Pathways related to Precocious Puberty according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.2ADCY9, ADCY8, ADCY3, LHCGR
2
Show member pathways
7.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
3
Show member pathways
7.6ADCY3, ADCY8, ADCY9, ADCY6, ADCY5
4
Show member pathways
7.6ADCY8, ADCY6, ADCY9, ADCY3, ADCY5
5
Show member pathways
Signal transduction cAMP signaling60
7.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
6
Show member pathways
7.6ADCY5, ADCY6, ADCY9, ADCY8, ADCY3
7
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
7.6ADCY3, ADCY6, ADCY5, ADCY8, ADCY9
8
Show member pathways
7.6ADCY6, ADCY8, ADCY5, ADCY3, ADCY9
9
Show member pathways
Calcium Regulation in the Cardiac Cell37
7.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
10
Show member pathways
UTP and CTP dephosphorylation II37
ATP ITP metabolism60
purine deoxyribonucleosides salvage37
7.6ADCY6, ADCY3, ADCY5, ADCY8, ADCY9
11
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
7.6ADCY8, ADCY6, ADCY5, ADCY3, ADCY9
12
Show member pathways
7.6ADCY5, ADCY8, ADCY9, ADCY6, ADCY3
13
Show member pathways
7.6ADCY6, ADCY5, ADCY3, ADCY8, ADCY9
14
Show member pathways
7.6ADCY6, ADCY3, ADCY5, ADCY8, ADCY9
157.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
16
Show member pathways
7.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
177.6ADCY3, ADCY5, ADCY6, ADCY9, ADCY8
18
Show member pathways
7.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
197.6ADCY3, ADCY6, ADCY8, ADCY9, ADCY5
20
Show member pathways
7.6ADCY6, ADCY3, ADCY5, ADCY8, ADCY9
217.6ADCY6, ADCY5, ADCY8, ADCY9, ADCY3
227.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
23
Show member pathways
7.6ADCY5, ADCY6, ADCY9, ADCY8, ADCY3
24
Show member pathways
7.6ADCY6, ADCY5, ADCY3, ADCY8, ADCY9
257.6ADCY6, ADCY3, ADCY5, ADCY8, ADCY9
26
Show member pathways
7.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
27
Show member pathways
7.6ADCY3, ADCY6, ADCY9, ADCY8, ADCY5
28
Show member pathways
7.6ADCY6, ADCY9, ADCY3, ADCY5, ADCY8
29
Show member pathways
7.6ADCY5, ADCY3, ADCY8, ADCY9, ADCY6
30
Show member pathways
7.6ADCY9, ADCY3, ADCY8, ADCY5, ADCY6
31
Show member pathways
7.6ADCY5, ADCY3, ADCY8, ADCY9, ADCY6
32
Show member pathways
7.6ADCY5, ADCY9, ADCY6, ADCY3, ADCY8
33
Show member pathways
7.6ADCY9, ADCY8, ADCY3, ADCY6, ADCY5
347.6ADCY3, ADCY9, ADCY6, ADCY5, ADCY8
357.6ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
36
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
7.6ADCY6, ADCY3, ADCY9, ADCY8, ADCY5
37
Show member pathways
7.6ADCY9, ADCY3, ADCY6, ADCY8, ADCY5
387.6ADCY9, ADCY5, ADCY6, ADCY3, ADCY8
39
Show member pathways
7.6ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
407.6ADCY9, ADCY6, ADCY8, ADCY5, ADCY3
41
Show member pathways
7.6ADCY3, ADCY9, ADCY5, ADCY6, ADCY8
427.6ADCY8, ADCY3, ADCY5, ADCY9, ADCY6
43
Show member pathways
7.6ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
44
Show member pathways
7.6ADCY5, ADCY9, ADCY6, ADCY3, ADCY8
45
Show member pathways
7.6ADCY3, ADCY8, ADCY9, ADCY5, ADCY6
46
Show member pathways
7.3LHCGR, ADCY3, ADCY5, ADCY9, ADCY6, ADCY8
477.3ADCY6, ADCY9, ADCY8, ADCY3, LHCGR, ADCY5
487.3ADCY8, ADCY3, LHCGR, ADCY5, ADCY9, ADCY6
49
Show member pathways
6.9ADCY6, ADCY8, ADCY5, ADCY3, LHCGR, ADCY9
50
Show member pathways
6.9ADCY6, ADCY8, KISS1R, ADCY5, ADCY3, ADCY9

Compounds for genes affiliated with Precocious Puberty

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Compounds related to Precocious Puberty according to GeneCards/GeneDecks:

(show all 18)
idCompoundScoreTop Affiliating Genes
1forskolin44 50 1110.5ADCY9, ADCY5, ADCY3, LHCGR
2adenylate448.2LHCGR, ADCY3, ADCY5, ADCY9, ADCY6
3nkh 477618.0ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
4pacap 1-27618.0ADCY8, ADCY5, ADCY3, ADCY9, ADCY6
5mdl 12330a hydrochloride617.9ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
6kh 7617.9ADCY3, ADCY6, ADCY9, ADCY8, ADCY5
7sq 2253644 618.9ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
8Cyclic GMP247.9ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
9Pyruvic acid24 118.9ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
10nad28 248.9ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
11phosphoric acid44 248.8ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
12pyrophosphate44 248.8ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
13nadh44 24 119.8ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
14Guanosine triphosphate247.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
15magnesium44 24 119.5ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
16cyclic amp44 248.5LHCGR, ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
17Adenosine triphosphate24 118.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
18calcium44 50 24 1110.0LHCGR, ADCY3, ADCY5, ADCY8, ADCY9, ADCY6

GO Terms for genes affiliated with Precocious Puberty

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Cellular components related to Precocious Puberty according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ciliumGO:0059299.6ADCY6, ADCY3
2plasma membraneGO:0058866.6KISS1R, ADCY6, ADCY9, ADCY8, ADCY5, ADCY3

Biological processes related to Precocious Puberty according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1activation of protein kinase A activityGO:0341997.9ADCY6, ADCY3, ADCY5, ADCY8, ADCY9
2cellular response to glucagon stimulusGO:0713777.9ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071897.9ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
4water transportGO:0068337.9ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071937.9ADCY8, ADCY5, ADCY9, ADCY6, ADCY3
6activation of phospholipase C activityGO:0072027.9ADCY9, ADCY8, ADCY6, ADCY3, ADCY5
7energy reserve metabolic processGO:0061127.9ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
8fibroblast growth factor receptor signaling pathwayGO:0085437.8ADCY9, ADCY8, ADCY5, ADCY3, ADCY6
9epidermal growth factor receptor signaling pathwayGO:0071737.8ADCY3, ADCY9, ADCY8, ADCY5, ADCY6
10neurotrophin TRK receptor signaling pathwayGO:0480117.8ADCY6, ADCY3, ADCY5, ADCY8, ADCY9
11intracellular signal transductionGO:0355567.8ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
12synaptic transmissionGO:0072687.7ADCY5, ADCY8, ADCY9, ADCY6, ADCY3
13transmembrane transportGO:0550857.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
14small molecule metabolic processGO:0442817.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
15innate immune responseGO:0450877.5ADCY3, ADCY5, ADCY8, ADCY9, ADCY6
16signal transductionGO:0071657.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6

Molecular functions related to Precocious Puberty according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion bindingGO:0468727.6ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
2adenylate cyclase activityGO:0040167.5ADCY6, ADCY9, ADCY8, ADCY5, ADCY3
3ATP bindingGO:0055247.3ADCY3, ADCY5, ADCY8, ADCY9, ADCY6

Products for genes affiliated with Precocious Puberty

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Sources for Precocious Puberty

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet