MCID: PRC019
MIFTS: 50

Precocious Puberty malady

Endocrine diseases, Genetic diseases categories

Summaries for Precocious Puberty

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Precocious puberty is when a person's sexual and physical traits develop and mature earlier than normal. normal puberty typically begins between ages 10 and 14 for girls, and ages 12 and 16 for boys. the start of puberty depends on various factors such as family history, nutrition and gender. the cause of precocious puberty is not always known. some cases of precocious puberty are due to conditions that cause changes in the body's release of hormones. treatment involves medications that can stop the release of sexual hormones. last updated: 12/21/2012

MalaCards: Precocious Puberty, also known as cryptogenic sexual precocity, is related to mccune albright syndrome and hypothyroidism. An important gene associated with Precocious Puberty is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Regulation of Insulin Secretion and Gastric acid secretion. The drugs gonadorelin and gonadorelin acetate and the compounds nafarelin and buserelin have been mentioned in the context of this disorder. Affiliated tissues include brain and pituitary, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Wikipedia:63 In medicine, precocious puberty is puberty occurring at an unusually early age. In most of these... more...

Aliases & Classifications for Precocious Puberty

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42NIH Rare Diseases, 22GTR, 60UMLS, 44Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

precocious puberty 42 22 60
cryptogenic sexual precocity 60
familial precocious puberty 42
idiopathic sexual precocity 42
puberty precocious 44
sexual precocity 42


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ICD1025 E30.1

Related Diseases for Precocious Puberty

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17GeneCards, 18GeneDecks
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Diseases in the Precocious Puberty family:

Central Precocious Puberty Precocious Puberty, Central, 2
Precocious Puberty, Central, 1

Diseases related to Precocious Puberty via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1mccune albright syndrome31.2GNRH1, ADCY2
2hypothyroidism30.9FSHR, LSL, GNRH1, IGF1
3precocious puberty, male30.7LHCGR, FSHR, CYP19A1
4polycystic ovary syndrome30.7CYP21A2, LSL, CYP19A1, FSHR, GNRH1, IGF1
5obesity30.6LSL, NR0B1, IGF1, CYP21A2, FSHR
6hyperandrogenism30.6FSHR, CYP21A2, CYP19A1, IGF1, GNRH1, LSL
7congenital adrenal hyperplasia30.6CYP21A2, CYP19A1, NR0B1, GNRH1, LSL
8adenoma30.6ADCY1, NR0B1, LHCGR, GNRH1, IGF1, CYP21A2
9leydig cell tumor30.5GNRH1, CYP21A2, LHCGR, NR0B1, CYP19A1
10klinefelter's syndrome30.5KISS1, CYP19A1, KISS1R, GNRH1, CYP21A2, NR0B1
11hypogonadism30.5IGF1, NR0B1, CYP19A1, FSHR, KISS1, KISS1R
12hypogonadotropism30.4GNRH1, KISS1R
13turner syndrome30.4GNRH1, IGF1
14pseudohermaphroditism30.3CYP19A1, LHCGR
15gonadal dysgenesis30.3NR0B1
16hypertension30.3IGF1, ADCY2
17adrenal adenoma30.3NR0B1, CYP19A1, CYP21A2
18ovarian cyst30.3GNRH1, CYP19A1
19diabetes mellitus30.3LSL, IGF1
20pseudohypoparathyroidism30.2ADCY2
21hypopituitarism30.2IGF1, CYP21A2, GNRH1
22amenorrhea30.1FSHR, IGF1, GNRH1
23endometriosis30.1FSHR, CYP19A1, GNRH1
24choriocarcinoma30.0GNRH1, KISS1, CYP19A1
25gynecomastia30.0CYP19A1, GNRH1
26hyperprolactinemia30.0GNRH1, IGF1
27adrenocortical carcinoma30.0CYP21A2, CYP19A1, NR0B1
28cushing's syndrome30.0CYP21A2, NR0B1, GNRH1, LSL, LHCGR, IGF1
29infertility30.0FSHR, CYP21A2, CYP19A1, GNRH1, LSL, LHCGR
30familial male-limited precocious puberty10.6
31spastic paraplegia with precocious puberty10.6
32precocious puberty, central, 210.5
33precocious puberty, central, 110.5
34testotoxicosis10.4
35vaginitis10.4
36neurofibromatosis10.4
37mediastinitis10.4
38central precocious puberty10.4
39empty sella syndrome10.3
40prader-willi syndrome10.3
41craniopharyngioma10.3
42histiocytosis10.3
43idiopathic central precocious puberty10.3
44peripheral precocious puberty10.3
45intellectual deficit, x-linked - precocious puberty - obesity10.3
4621-hydroxylase deficiency10.2
47narcolepsy10.2
48tuberous sclerosis10.2
49gonadoblastoma10.2
50congenital hypothyroidism10.2

Graphical network of the top 20 diseases related to Precocious Puberty:



Diseases related to precocious puberty

Clinical Features for Precocious Puberty

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Drugs & Therapeutics for Precocious Puberty

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Precocious Puberty

Search NIH Clinical Center for Precocious Puberty

Search CenterWatch for Precocious Puberty

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Precocious Puberty

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22GTR
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Genetic tests related to Precocious Puberty:

id Genetic test Affiliating Genes
1 Precocious Puberty22

Anatomical Context for Precocious Puberty

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32MalaCards
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MalaCards organs/tissues related to Precocious Puberty:

32
Brain, Pituitary

Animal Models for Precocious Puberty or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Precocious Puberty:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.2GNRH1, IGF1, KISS1R, KISS1, ADCY6, LHCGR
2MP:000537910.2LHCGR, GNRH1, NR0B1, IGF1, CYP19A1, FSHR
3MP:000538910.2ADCY3, LHCGR, GNRH1, NR0B1, IGFALS, IGF1
4MP:001077110.1GNRH1, IGF1, CYP19A1, FSHR, KISS1R, KISS1
5MP:000537610.1CYP19A1, IGF1, NR0B1, GNRH1, LHCGR, FSHR
6MP:000537810.0LHCGR, GNRH1, IGFALS, IGF1, CYP19A1, FSHR
7MP:000538610.0LHCGR, CYP19A1, FSHR, KISS1R, ADCY7, ADCY6
8MP:00036319.7GNRH1, IGF1, CYP19A1, FSHR, KISS1R, KISS1

Publications for Precocious Puberty

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Genetic Variations for Precocious Puberty

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Expression for genes affiliated with Precocious Puberty

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Precocious Puberty

Search GEO for disease gene expression data for Precocious Puberty.

Pathways for genes affiliated with Precocious Puberty

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53Reactome, 29KEGG, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore
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Pathways related to Precocious Puberty according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1ADCY2, ADCY3, ADCY9, ADCY7, ADCY5, ADCY6
2
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10.1ADCY3, ADCY6, ADCY2, ADCY7, ADCY9, ADCY5
3
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10.1ADCY6, ADCY2, ADCY3, ADCY1, ADCY8, ADCY7
4
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10.1ADCY5, ADCY1, ADCY8, ADCY9, ADCY6, ADCY3
5
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10.1ADCY3, ADCY5, ADCY9, ADCY6, ADCY7, ADCY1
6
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10.1ADCY8, ADCY5, ADCY9, ADCY2, ADCY6, ADCY3
710.1ADCY1, ADCY3, ADCY9, LHCGR, ADCY7, ADCY4
8
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10.0ADCY6, ADCY3, ADCY7, ADCY2, ADCY9, ADCY5
910.0ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
1010.0ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
11
G-protein signaling G-Protein alpha-i signaling cascades
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10.0ADCY6, ADCY3, ADCY7, ADCY2, ADCY9, ADCY5
1210.0ADCY6, ADCY3, ADCY7, ADCY4, ADCY8, ADCY1
13
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10.0ADCY6, ADCY3, ADCY7, ADCY2, ADCY9, ADCY5
1410.0ADCY7, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9
1510.0ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
16
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10.0ADCY6, ADCY2, ADCY9, ADCY7, ADCY1, ADCY4
1710.0ADCY7, ADCY2, ADCY6, ADCY3, ADCY8, ADCY5
18
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10.0ADCY3, ADCY2, ADCY9, ADCY4, ADCY6, ADCY5
19
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10.0ADCY2, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9
20
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10.0ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
21
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10.0ADCY7, ADCY3, ADCY4, ADCY8, ADCY1, ADCY5
2210.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
2310.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
24
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
10.0ADCY6, ADCY3, ADCY4, ADCY8, ADCY1, ADCY5
2510.0ADCY7, ADCY3, ADCY6, ADCY4, ADCY8, ADCY1
26
Signal transduction cAMP signaling
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10.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
2710.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
28
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10.0ADCY8, ADCY5, ADCY2, ADCY1, ADCY6, ADCY7
2910.0ADCY8, ADCY2, ADCY9, ADCY6, ADCY3, ADCY7
3010.0ADCY3, ADCY6, ADCY2, ADCY9, ADCY1, ADCY8
31
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10.0ADCY4, ADCY8, ADCY2, ADCY1, ADCY5, ADCY9
32
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10.0ADCY6, ADCY2, ADCY9, ADCY8, ADCY4, ADCY1
33
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10.0ADCY1, ADCY5, ADCY9, ADCY2, ADCY6, ADCY3
34
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10.0ADCY7, ADCY6, ADCY2, ADCY3, ADCY5, ADCY1
3510.0ADCY4, ADCY6, ADCY7, ADCY2, ADCY9, ADCY5
36
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10.0ADCY1, ADCY8, ADCY7, ADCY4, ADCY5, ADCY9
37
Development Endothelin-1/EDNRA signaling
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10.0GNRH1, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
38
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10.0ADCY9, ADCY8, ADCY1, ADCY2, GNRH1, ADCY3
39
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10.0ADCY6, ADCY2, ADCY9, ADCY5, ADCY1, ADCY4
40
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10.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
41
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9.9ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
42
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9.9ADCY8, ADCY3, ADCY1, ADCY7, ADCY6, IGF1
43
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9.9ADCY9, ADCY8, ADCY1, ADCY6, ADCY3, ADCY7
44
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9.9ADCY3, ADCY2, ADCY1, ADCY5, ADCY9, ADCY4
45
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9.9ADCY9, ADCY8, ADCY1, ADCY4, ADCY2, ADCY6
46
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9.9IGF1, ADCY7, ADCY3, GNRH1, ADCY2, ADCY8
47
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9.9LHCGR, GNRH1, ADCY5, ADCY1, ADCY9, ADCY2
48
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9.9ADCY8, ADCY6, ADCY1, ADCY5, ADCY2, ADCY9
499.8ADCY4, ADCY8, LHCGR, IGF1, CYP19A1, ADCY1
50
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9.8ADCY8, LHCGR, ADCY1, ADCY5, KISS1, GNRH1

Compounds for genes affiliated with Precocious Puberty

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Precocious Puberty according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1nafarelin44 59 28 1113.7GNRH1, CYP19A1, CYP21A2
2buserelin44 28 1112.7LHCGR, GNRH1, IGF1, CYP19A1
3goserelin44 28 1112.7CYP19A1, GNRH1, LSL, LHCGR
4leuprolide acetate4410.7GNRH1, IGF1, CYP19A1, CYP21A2, LHCGR
5cetrorelix44 28 1112.6GNRH1, LHCGR, IGF1
6leuprolide44 59 28 1113.6LSL, GNRH1, IGF1
7clomiphene citrate4410.6GNRH1, IGF1, CYP19A1, CYP21A2
8Menotropins1110.6FSHR, LHCGR
9raloxifene44 28 49 1113.6IGF1, LSL, CYP19A1, GNRH1
10forskolin44 49 1112.6ADCY5, LHCGR, ADCY7, ADCY3, ADCY2, ADCY9
11dehydroepiandrosterone sulfate4410.6CYP21A2, CYP19A1, IGF1, LSL, GNRH1
12metformin44 49 1112.6IGF1, GNRH1, CYP19A1, LSL
13Choriogonadotropin alfa1110.6FSHR, LHCGR
14dhea4410.6LSL, CYP21A2, CYP19A1, IGF1
15androstenedione44 2411.6GNRH1, CYP21A2, CYP19A1, FSHR, LSL, IGF1
16progestin4410.6LHCGR, IGF1, GNRH1, CYP19A1
17tibolone4410.5GNRH1, LSL, CYP19A1
18isoproterenol44 1111.5ADCY1, ADCY7, GNRH1, LHCGR, ADCY3, ADCY2
19acth4410.5CYP21A2, NR0B1, LHCGR, ADCY1, IGF1, GNRH1
20ribonucleic acid4410.5GNRH1, IGF1, FSHR, CYP21A2, LHCGR
21estrone44 28 11 2413.5GNRH1, CYP19A1, IGF1, LSL
2217-hydroxyprogesterone44 2411.5GNRH1, CYP21A2, CYP19A1
23estradiol44 11 2412.5CYP19A1, IGF1, LHCGR, LSL, GNRH1, FSHR
24nkh 4775910.5ADCY4, ADCY8, ADCY5, ADCY9, ADCY2, ADCY6
25kh 75910.5ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
26pacap 1-275910.5ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
27adenylate4410.5ADCY2, LHCGR, ADCY6, FSHR, ADCY3, ADCY9
28Pyruvic acid11 2411.5ADCY7, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9
29sq 2253659 4411.5ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
30dopamine44 28 11 2413.5ADCY1, ADCY2, GNRH1, IGF1, ADCY6, ADCY5
31mdl 12330a hydrochloride5910.5ADCY4, ADCY8, ADCY3, ADCY1, ADCY5, ADCY9
32nad28 2411.5ADCY3, ADCY7, ADCY6, ADCY9, ADCY5, ADCY1
33phosphoric acid44 2411.4ADCY9, ADCY4, ADCY8, ADCY1, ADCY7, ADCY3
34nadh44 11 2412.4ADCY4, ADCY8, ADCY1, ADCY9, ADCY7, ADCY3
35pyrophosphate44 2411.4ADCY2, ADCY9, ADCY5, ADCY1, ADCY6, ADCY3
36gnrh4410.4IGF1, CYP19A1, CYP21A2, FSHR, KISS1R, KISS1
37flutamide44 59 1112.4GNRH1, CYP19A1, LHCGR
38testosterone44 59 11 2413.4KISS1, FSHR, CYP19A1, LHCGR, GNRH1, LSL
39steroid4410.4FSHR, KISS1, CYP21A2, CYP19A1, IGF1, NR0B1
40fmpp4410.4FSHR, LHCGR
41arginine4410.4ADCY1, LHCGR, LSL, GNRH1, IGF1, CYP19A1
42Adenosine triphosphate11 2411.4ADCY4, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
43progesterone44 59 28 11 2414.4GNRH1, IGF1, LSL, LHCGR, NR0B1, FSHR
44hydrocortisone44 2 59 1113.4CYP19A1, CYP21A2, LSL, IGF1
45magnesium44 11 2412.4ADCY2, ADCY6, ADCY3, ADCY7, ADCY9, ADCY5
46cyclic amp44 2411.3ADCY3, ADCY1, ADCY5, ADCY2, LHCGR, NR0B1
472',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE1110.3ADCY2, ADCY5
48thyroxine44 2411.3CYP21A2, IGF1, GNRH1, LSL
49calcium44 49 11 2413.2ADCY6, ADCY2, ADCY3, ADCY7, ADCY5, KISS1
50dihydrotestosterone44 28 11 2413.0CYP21A2, CYP19A1, IGF1, GNRH1

GO Terms for genes affiliated with Precocious Puberty

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16Gene Ontology
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Cellular components related to Precocious Puberty according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:01602010.2CYP19A1, ADCY6, ADCY2, ADCY8, ADCY4, NR0B1
2plasma membraneGO:0058869.5ADCY4, LHCGR, IGF1, FSHR, KISS1R, ADCY7

Biological processes related to Precocious Puberty according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1sterol metabolic processGO:01612510.4CYP21A2, CYP19A1
2prostate gland growthGO:06073610.4CYP19A1, IGF1
3cellular response to glucagon stimulusGO:07137710.4ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
4cAMP biosynthetic processGO:00617110.4ADCY6, ADCY2, ADCY1, ADCY4
5activation of protein kinase A activityGO:03419910.4ADCY4, ADCY8, ADCY1, ADCY5, ADCY7, ADCY3
6activation of phospholipase C activityGO:00720210.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
7adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
8energy reserve metabolic processGO:00611210.3ADCY4, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
9water transportGO:00683310.3ADCY9, ADCY5, ADCY1, ADCY8, ADCY4, ADCY2
10adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY4, ADCY8
11fibroblast growth factor receptor signaling pathwayGO:00854310.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
12epidermal growth factor receptor signaling pathwayGO:00717310.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
13intracellular signal transductionGO:03555610.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
14neurotrophin TRK receptor signaling pathwayGO:04801110.3ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
15male gonad developmentGO:00858410.2LHCGR, NR0B1, FSHR
16synaptic transmissionGO:00726810.2ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
17transmembrane transportGO:05508510.2ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
18innate immune responseGO:04508710.2ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
19positive regulation of synaptic transmissionGO:05080610.1KISS1, KISS1R
20signal transductionGO:00716510.1ADCY3, ADCY7, IGF1, IGFALS, GNRH1, ADCY6
21small molecule metabolic processGO:04428110.0CYP19A1, CYP21A2, ADCY7, ADCY3, ADCY6, ADCY2

Molecular functions related to Precocious Puberty according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase bindingGO:00817910.4ADCY5, ADCY2
2calcium- and calmodulin-responsive adenylate cyclase activityGO:00829410.3ADCY2, ADCY1, ADCY8
3adenylate cyclase activityGO:00401610.1ADCY4, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
4ATP bindingGO:0055249.9ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5
5metal ion bindingGO:0468729.7ADCY7, ADCY3, ADCY6, ADCY2, ADCY9, ADCY5

Products for genes affiliated with Precocious Puberty

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  • Antibodies
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Sources for Precocious Puberty

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet