MCID: PRC019
MIFTS: 52

Precocious Puberty

Categories: Rare diseases, Endocrine diseases, Reproductive diseases, Genetic diseases

Aliases & Classifications for Precocious Puberty

MalaCards integrated aliases for Precocious Puberty:

Name: Precocious Puberty 49 36 28 69
Cryptogenic Sexual Precocity 69
Familial Precocious Puberty 49
Idiopathic Sexual Precocity 49
Puberty Precocious 51
Sexual Precocity 49

Classifications:



External Ids:

KEGG 36 H00937
ICD10 32 E30.1

Summaries for Precocious Puberty

NIH Rare Diseases : 49 Precocious puberty is when a person's sexual and physical traits develop and mature earlier than normal. Normal puberty typically begins between ages 10 and 14 for girls, and ages 12 and 16 for boys. The start of puberty depends on various factors such as family history, nutrition and gender. The cause of precocious puberty is not always known. Some cases of precocious puberty are due to conditions that cause changes in the body's release of hormones. Treatment involves medications that can stop the release of sexual hormones. Last updated: 12/21/2012

MalaCards based summary : Precocious Puberty, also known as cryptogenic sexual precocity, is related to precocious puberty, male-limited and central precocious puberty. An important gene associated with Precocious Puberty is LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor), and among its related pathways/superpathways are Calcium signaling pathway and Neuroactive ligand-receptor interaction. The drugs Leuprolide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and pituitary, and related phenotypes are adipose tissue and endocrine/exocrine gland

Related Diseases for Precocious Puberty

Diseases in the Precocious Puberty family:

Precocious Puberty, Central, 1 Precocious Puberty, Central, 2
Central Precocious Puberty Secondary Central Precocious Puberty

Diseases related to Precocious Puberty via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 precocious puberty, male-limited 34.1 CYP19A1 LHCGR
2 central precocious puberty 33.5 GNRH1 KISS1 KISS1R MKRN3
3 idiopathic central precocious puberty 33.4 KISS1 KISS1R MKRN3
4 testotoxicosis 33.0 CYP19A1 LHCGR
5 mccune-albright syndrome 32.5 CYP19A1 GH1 GNAS
6 hypothalamic hamartomas 32.2 GNRH1 KISS1 KISS1R
7 empty sella syndrome 30.3 GH1 GNRH1
8 adenoma 30.2 GH1 GNAS LHCGR
9 hypogonadotropic hypogonadism 30.2 GNRH1 KISS1 KISS1R
10 fibrous dysplasia 30.0 GH1 GNAS
11 hypogonadotropism 30.0 GNRH1 KISS1 KISS1R
12 prader-willi syndrome 29.9 GH1 GNRH1 MKRN3
13 amenorrhea 29.9 GNRH1 LHCGR
14 adrenal rest tumor 29.9 CYP21A2 GNRH1
15 pseudohermaphroditism 29.9 CYP19A1 LHCGR
16 hyperprolactinemia 29.8 GH1 GNRH1
17 leydig cell tumor 29.7 CYP19A1 CYP21A2 LHCGR
18 estrogen excess 29.7 CYP19A1 LHCGR
19 hypogonadism 29.7 GNRH1 KISS1 KISS1R LHCGR
20 hyperandrogenism 29.7 CYP19A1 CYP21A2 GNRH1
21 polycystic ovary syndrome 29.6 CYP19A1 CYP21A2 GNRH1
22 adrenocortical carcinoma, hereditary 29.3 CYP19A1 CYP21A2
23 infertility 29.3 CYP19A1 GNRH1 LHCGR
24 familial male-limited precocious puberty 12.5
25 precocious puberty, central, 2 12.5
26 precocious puberty, central, 1 12.5
27 spastic paraplegia with precocious puberty 12.3
28 hypotonia, seizures, and precocious puberty 12.2
29 secondary central precocious puberty 12.2
30 precocious puberty, gonadotropin-dependent 12.1
31 x-linked intellectual disability-precocious puberty-obesity syndrome 12.1
32 aromatase excess syndrome 11.4
33 carpenter syndrome 1 11.1
34 polyembryoma 11.0
35 mental retardation, x-linked 102 11.0
36 pineal gland cancer 11.0
37 pallister-hall syndrome 11.0
38 adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency 11.0
39 ovarian sex cord tumor with annular tubules 11.0
40 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.6
41 aging 10.4
42 body mass index quantitative trait locus 1 10.4
43 hypothyroidism 10.4
44 body mass index quantitative trait locus 12 10.3
45 body mass index quantitative trait locus 14 10.3
46 body mass index quantitative trait locus 9 10.3
47 body mass index quantitative trait locus 8 10.3
48 body mass index quantitative trait locus 18 10.3
49 body mass index quantitative trait locus 11 10.3
50 body mass index quantitative trait locus 7 10.3

Graphical network of the top 20 diseases related to Precocious Puberty:



Diseases related to Precocious Puberty

Symptoms & Phenotypes for Precocious Puberty

MGI Mouse Phenotypes related to Precocious Puberty:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.77 KISS1 KISS1R LHCGR CYP19A1 GNAS
2 endocrine/exocrine gland MP:0005379 9.73 KISS1 KISS1R LHCGR CYP19A1 GNAS GNRH1
3 digestive/alimentary MP:0005381 9.72 KISS1 KISS1R LHCGR CYP19A1 GNRH1
4 integument MP:0010771 9.55 GNRH1 KISS1 KISS1R CYP19A1 GNAS
5 liver/biliary system MP:0005370 9.43 KISS1 KISS1R LHCGR CYP19A1 GNAS GNRH1
6 renal/urinary system MP:0005367 9.1 KISS1 KISS1R LHCGR CYP19A1 GNAS GNRH1

Drugs & Therapeutics for Precocious Puberty

Drugs for Precocious Puberty (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Leuprolide Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 53714-56-0 657181 3911
2
Metformin Approved Phase 4 657-24-9 4091 14219
3 Deslorelin Phase 4,Phase 2,Phase 3
4 Fertility Agents Phase 4,Phase 2,Phase 3,Early Phase 1
5 Contraceptive Agents Phase 4,Phase 3
6 Triptorelin Pamoate Phase 4,Phase 3
7 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Early Phase 1
8 Luteolytic Agents Phase 4,Phase 3
9 insulin Phase 4
10 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
11 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
13 Hypoglycemic Agents Phase 4
14 Insulin, Globin Zinc Phase 4
15 Pharmaceutical Solutions Phase 3,Phase 2
16
Testosterone Approved, Investigational Phase 2 58-22-0 6013
17
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
18
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
19
Testolactone Approved, Investigational Phase 2 968-93-4 13769
20
Bicalutamide Approved Phase 2 90357-06-5 2375 56069
21
Fulvestrant Approved, Investigational Phase 2 129453-61-8 17756771 104741
22 diuretics Phase 2
23 Mineralocorticoid Receptor Antagonists Phase 2
24 Mineralocorticoids Phase 2
25 Steroid Synthesis Inhibitors Phase 2,Phase 1
26 Natriuretic Agents Phase 2
27 Androgens Phase 2,Phase 1
28 Diuretics, Potassium Sparing Phase 2
29 Estrogen Antagonists Phase 2,Phase 1
30 Estrogens Phase 2,Phase 1
31 Prolactin Release-Inhibiting Factors Phase 2
32 Aromatase Inhibitors Phase 2,Phase 1
33 Bone Density Conservation Agents Phase 1, Phase 2
34 Calcium, Dietary Phase 1, Phase 2
35 Androgen Antagonists Phase 2
36 Estrogen Receptor Antagonists Phase 2
37
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
38
Oxandrolone Approved, Investigational Phase 1 53-39-4 5878
39 Anabolic Agents Phase 1
40
Zinc Approved, Investigational 7440-66-6 32051 23994
41
Histamine Approved, Investigational 51-45-6, 75614-87-8 774
42
Ganirelix Approved Early Phase 1 124904-93-4, 123246-29-7 25081094
43
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
44
Epinephrine Approved, Vet_approved 51-43-4 5816
45
Menotropins Approved 9002-68-0, 61489-71-2 5360545
46 Racepinephrine Approved 329-65-7
47
Histamine Phosphate 51-74-1 65513
48 Follicle Stimulating Hormone Early Phase 1
49 Neurotransmitter Agents
50 Dexamethasone acetate 1177-87-3

Interventional clinical trials:

(show top 50) (show all 52)

# Name Status NCT ID Phase Drugs
1 Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children Unknown status NCT00438217 Phase 4 Triptorelin (GnRH agonists);Leuprolide (GnRH agonists)
2 Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in Girls Unknown status NCT01278290 Phase 4 Triptorelin acetate and Gonadorelin acetate;Gonadorelin acetate and Triptorelin acetate
3 Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty Completed NCT02920515 Phase 4 Triptorlin or Leuprorelin;Zhibo dihuang pills;Dabu ying pills
4 The Clinical Trial to Evaluate the Efficacy and Safety of Luphere Depot Inj. 3.75mg(Leuprolide Acetate 3.75mg) in Patients With Precocious Puberty Completed NCT01634321 Phase 4 Luphere depot 3.75mg(Leuprolide acetate 3.75mg)
5 Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty Recruiting NCT03316482 Phase 4 Leuplin DPS 11.25mg
6 Analysis of Body Mass Index in Central Precocious Puberty Patients Treated With Leuprolide Acetate Recruiting NCT02974270 Phase 4 Leuprolide
7 A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty in Chinese Patients Active, not recruiting NCT02427958 Phase 4 Leuprorelin
8 A 4 Year Combination Therapy of Growth Hormone and (GnRH) Agonist in Children With a Short Predicted Height Active, not recruiting NCT00840944 Phase 4 somatropin;triptorelin
9 The Health Influences of Puberty (HIP) Study Active, not recruiting NCT01775813 Phase 4 Metformin
10 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3 Leuprolide acetate (Lupron)
11 Efficacy, Safety, and Pharmacokinetics (PK) of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty Completed NCT01467882 Phase 3 Triptorelin
12 Histrelin Subcutaneous Implant in Children With Central Precocious Puberty Completed NCT00779103 Phase 3 Histrelin Subcutaneous Implant
13 Effects of Triptorelin Pamoate in Children With Precocious Puberty - Follow up Study Completed NCT00909844 Phase 3 Triptorelin (I.N.N.)
14 Efficacy and Safety Study of Pamoate of Triptorelin in Children With Precocious Puberty Completed NCT00564850 Phase 3 Triptorelin pamoate 11.25mg (Decapeptyl® SR)
15 Safety Extension Study Of Leuprolide Acetate (Lupron Depot) In The Treatment Of Central Precocious Puberty Completed NCT00667446 Phase 3 Leuprolide Acetate 3 Month Depot
16 Study of Lupron Depot In The Treatment of Central Precocious Puberty Completed NCT00660010 Phase 3 Lupron (leuprolide acetate)
17 A Study of Leuprolide 11.25 mg and 30 mg Administered Every 3 Months to Treat Central Precocious Puberty Completed NCT00635817 Phase 3 Leuprolide acetate 11.25 mg;Leuprolide acetate 30 mg
18 Pharmacokinetic Study of Leuprolide Acetate Injectable Suspension in the Treatment of Central Precocious Puberty Active, not recruiting NCT02452931 Phase 3 Leuprolide Acetate 45 mg
19 Severe Decrease of Growth Velocity in Children With Anorexia Nervosa.Therapeutic Trial of Growth Hormone Active, not recruiting NCT01626833 Phase 2, Phase 3 SOMATROPINE* : Norditropine® simplexx®
20 Treatment of Boys With Precocious Puberty Completed NCT00001202 Phase 2 Spironolactone;Testolactone;Deslorelin
21 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed NCT00001181 Phase 2 Testolactone
22 Encouraging Calcium Absorption and Bone Formation During Early Puberty Completed NCT00022867 Phase 1, Phase 2 Nondigestible oligosaccharide (NDO)
23 Arimidex in McCune Albright Syndrome Completed NCT00055302 Phase 2 Arimidex 1 mg
24 Study of Luteinizing Hormone-Releasing Hormone Analog (LHRHa) in Pubertal Patients With Extreme Short Stature Completed NCT00001190 Phase 2 Deslorelin
25 Faslodex in McCune Albright Syndrome Active, not recruiting NCT00278915 Phase 2 Fulvestrant
26 Pediatrics Testotoxicosis Study [Bicalutamide Anastrozole Treatment for Testotoxicosis] Active, not recruiting NCT00094328 Phase 2 Bicalutamide;Anastrozole
27 Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome Completed NCT00006174 Phase 1 Letrozole
28 Pilot Study of the Safety and Efficacy of Oxandrolone in the Prevention and Treatment of Malnutrition in Infants Active, not recruiting NCT01048632 Phase 1 Oxandrolone
29 Markers of Pubertal Suppression During Therapy for Precocious Puberty Unknown status NCT02006680
30 First-Voided Urinary LH vs. GnRH-stimulation in Differentiating Slowly- From Rapidly Progressive-Precocious Puberty Unknown status NCT01800565
31 Follow-up of Girls With Premature Thelarche and Precocious Puberty Unknown status NCT01944475
32 LH Response to GnRH Test in Prepubescent Girls Under 6 Years Unknown status NCT01944488 GnRH agonist
33 Ultrasound Evaluation of Bone Age in Healthy Children Unknown status NCT01980693
34 Psychosocial Impact of Early Puberty in Girls Aged 6 to 8 Years Completed NCT01679925
35 Purification of Testis-Stimulating Factor in Precocious Puberty Completed NCT00004344 leuprolide;testosterone
36 Follicle-Stimulating Hormone (FSH) and the Onset of Puberty Completed NCT00734279 Early Phase 1 Leuprolide Acetate - Early Puberty Leuprolide Visit;Ganirelix - Early Puberty Ganirelix Visit;Ganirelix - Delayed Puberty Ganirelix Visit;Leuprolide Acetate- Delayed Puberty Leuprolide Visit
37 Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle Completed NCT00004335
38 Exercise in Insulin-Resistant Minority Adolescents Completed NCT00345436
39 Histamine Responsiveness in McCune-Albright Syndrome Completed NCT00318097
40 Clinical Trial of Experienced Chinese Herbal Formulas on Different Types of Precocious Puberty Recruiting NCT02650141 ziyinxiehuo Granules;zishenqinggan Granules
41 Effect of a GnRH Injection on Ghrelin Concentrations in Girls With Suspected Premature Puberty Recruiting NCT02431416 Gonadotropin releasing hormone (GnRH);Sodium Chloride
42 A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty (CPP) Among Chinese Participants Recruiting NCT02993926 Leuprorelin
43 The Effect of Medical Clown on the Pain and Anxiety Perception During LRH Analog Treatment or GH Provocation Test Recruiting NCT02199587
44 Association Between Soy Based Formula in Infancy and Puberty Recruiting NCT02908971
45 Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Recruiting NCT00001727
46 Inherited Reproductive Disorders Recruiting NCT01500447
47 Ovarian Contribution to Androgen Production in Adolescent Girls Recruiting NCT01421810 Dexamethasone;rhCG
48 The Genetic Investigation of Reproductive Disorders (Including Kallmann Syndrome) Recruiting NCT01601171
49 Long-term Outcome of GnRH Analogues Treatment of Children With Idiopathic Central Precocious Puberty Enrolling by invitation NCT02790112
50 Natural History Study of Patients With Excess Androgen Enrolling by invitation NCT00250159

Search NIH Clinical Center for Precocious Puberty

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Precocious Puberty

Genetic tests related to Precocious Puberty:

# Genetic test Affiliating Genes
1 Precocious Puberty 28

Anatomical Context for Precocious Puberty

MalaCards organs/tissues related to Precocious Puberty:

38
Bone, Testes, Pituitary, Ovary, Pineal, Testis, Brain

Publications for Precocious Puberty

Articles related to Precocious Puberty:

(show top 50) (show all 929)
# Title Authors Year
1
A Case of a Girl with Arnold-Chiari Type 1 Malformation with Precocious Puberty. ( 29383213 )
2018
2
The usefulness of circulating levels of leptin, kisspeptin, and neurokinin B in obese girls with precocious puberty. ( 29303010 )
2018
3
A case of Riley Ruvalcaba syndrome with a novel PTEN mutation accompanied by diffuse testicular microlithiasis and precocious puberty. ( 29194042 )
2018
4
Triptorelin (Triptodur) for central precocious puberty. ( 29294465 )
2018
5
Increased high molecular weight adiponectin, but decreased total adiponectin and kisspeptin, in central precocious puberty compared with aged-matched prepubertal girls. ( 28610651 )
2017
6
The influence of gonadotropin-releasing hormone agonists on anthropometric change in girls with central precocious puberty. ( 29302264 )
2017
7
GnRH-dependent precocious puberty manifested at the age of 14 months in a girl with 47,XXX karyotype. ( 29278519 )
2017
8
Treatment outcomes of gonadotropin-releasing hormone agonist in obese girls with central precocious puberty. ( 29301187 )
2017
9
Phacomatosis pigmentokeratotica and precocious puberty associated with HRAS mutation. ( 28489335 )
2017
10
Long-term Outcomes of Patients with Central Precocious Puberty due to Hypothalamic Hamartoma After GnRH Analog Treatment: Anthropometric, Metabolic and Reproductive Aspects. ( 28558376 )
2017
11
Characteristics of traditional Chinese medicine usage in children with precocious puberty: A nationwide population-based study. ( 28499829 )
2017
12
The first Japanese case of central precocious puberty with a novel MKRN3 mutation. ( 28546864 )
2017
13
Marshall-Smith syndrome: Novel pathogenic variant and previously unreported associations with precocious puberty and aortic root dilatation. ( 28442439 )
2017
14
Primary Mediastinal Pure Seminomatous Germ Cell Tumor (Germinoma) as a Rare Cause of Precocious Puberty in a 9 Year-Old Patient. ( 28888750 )
2017
15
Central Precocious Puberty Secondary to Adrenocortical Adenoma in a Female Child: Case Report and Review of the Literature. ( 28578183 )
2017
16
An FSH and TSH pituitary adenoma, presenting with precocious puberty and central hyperthyroidism. ( 28721217 )
2017
17
Genetic Variations of the KISS1R Gene in Korean Girls with Central Precocious Puberty. ( 27914139 )
2017
18
Higher phthalate concentrations are associated with precocious puberty in normal weight Thai girls. ( 29176028 )
2017
19
Metabolic Outcomes, Bone Health, and Risk of Polycystic Ovary Syndrome in Girls with Idiopathic Central Precocious Puberty Treated with Gonadotropin-Releasing Hormone Analogues. ( 28391271 )
2017
20
Precocious puberty: An experience from a major teaching hospital in Central Saudi Arabia. ( 29213166 )
2017
21
A novel DAX-1 mutation in two male siblings presenting with precocious puberty and late-onset hypogonadotropic hypogonadism. ( 28284037 )
2017
22
Advanced bone age as an indicator facilitates the diagnosis of precocious puberty. ( 28866322 )
2017
23
Effects of pomegranate extract in supplementing gonadotropin-releasing hormone therapy on idiopathic central precocious puberty in Chinese girls: a randomized, placebo-controlled, double-blind clinical trial. ( 28091641 )
2017
24
Preventive Effect and Safety of a Follicle Stimulating Hormone Inhibitory Formulation Containing a Mixture of<i>Coicis Semen</i>and<i>Artemisia capillaris</i>for Precocious Puberty: A Preliminary Experimental Study Using Female Rats. ( 29348765 )
2017
25
Commentary: Cognitive, Emotional, and Psychosocial Functioning of Girls Treated with Pharmacological Puberty Blockage for Idiopathic Central Precocious Puberty. ( 28167925 )
2017
26
There is no association between vitamin D status and characteristics of central precocious puberty in girls. ( 28963633 )
2017
27
One-Year Follow-Up of Girls with Precocious Puberty and Their Mothers: Do Psychological Assessments Change over Time or with Treatment? ( 28926827 )
2017
28
Insulin resistance and bone age advancement in girls with central precocious puberty. ( 29025204 )
2017
29
Lung Function in Women with Idiopathic Central Precocious Puberty: A Pilot Studya8c. ( 28114141 )
2017
30
Makorin ring finger 3 gene analysis in Koreans with familial precocious puberty. ( 28988223 )
2017
31
Meta-Analysis of Paediatric Patients with Central Precocious Puberty Treated with Intramuscular Triptorelin 11.25 mg 3-Month Prolonged-Release Formulationa8c. ( 28334719 )
2017
32
GnRH agonist treatment for idiopathic central precocious puberty can improve final adult height in Chinese girls. ( 29312590 )
2017
33
Corrigendum to: Increased high molecular weight adiponectin, but decreased total adiponectin and kisspeptin, in central precocious puberty compared with aged-matched prepubertal girls. ( 29145926 )
2017
34
Kisspeptin permits the sexual development of female rats with normal and precocious puberty but is not a trigger for it. ( 29298283 )
2017
35
Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty. ( 28791667 )
2017
36
MKRN3 levels in girls with central precocious puberty and correlation with sexual hormone levels: a pilot study. ( 28299573 )
2017
37
Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult Height in Familial Male Precocious Puberty. ( 29144249 )
2017
38
Paternally Inherited DLK1 Deletion Associated With Familial Central Precocious Puberty. ( 28324015 )
2017
39
Association study of LIN28B in girls with precocious puberty. ( 28525351 )
2017
40
Marked geographic patterns in the incidence of idiopathic central precocious puberty: a nationwide study in France. ( 28890442 )
2017
41
Change in body mass index and insulin resistance after 1-year treatment with gonadotropin-releasing hormone agonists in girls with central precocious puberty. ( 28443256 )
2017
42
Molecular Screening of MKRN3, DLK1, and KCNK9 Genes in Girls with Idiopathic Central Precocious Puberty. ( 28672280 )
2017
43
Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty. ( 28500430 )
2017
44
Effect of gonadotropin-releasing hormone analogue on final adult height among Jordanian children with precocious puberty. ( 29114697 )
2017
45
Treatment of Girls and Boys with McCune-Albright Syndrome with Precocious Puberty - Update 2017. ( 29292624 )
2017
46
Precocious Puberty or Premature Thelarche: Analysis of a Large Patient Series in a Single Tertiary Center with Special Emphasis on 6- to 8-Year-Old Girls. ( 28878739 )
2017
47
Peripheral Precocious Puberty due to Functioning Adrenocortical Tumor: Description of Two Cases. ( 27666809 )
2017
48
The influence of gonadotropin releasing hormone agonist treatment on the body weight and body mass index in girls with idiopathic precocious puberty and early puberty. ( 28690987 )
2017
49
The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP). ( 28251550 )
2017
50
The different effects of gonadotropin-releasing hormone agonist therapy on body mass index and growth between normal-weight and overweight girls with central precocious puberty. ( 28443259 )
2017

Variations for Precocious Puberty

Expression for Precocious Puberty

Search GEO for disease gene expression data for Precocious Puberty.

Pathways for Precocious Puberty

Pathways related to Precocious Puberty according to KEGG:

36
# Name Kegg Source Accession
1 Calcium signaling pathway hsa04020
2 Neuroactive ligand-receptor interaction hsa04080
3 GnRH signaling pathway hsa04912

GO Terms for Precocious Puberty

Biological processes related to Precocious Puberty according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.4 GNAS LHCGR
2 steroid biosynthetic process GO:0006694 9.37 CYP19A1 CYP21A2
3 G-protein coupled receptor signaling pathway GO:0007186 9.35 GNAS GNRH1 KISS1 KISS1R LHCGR
4 cognition GO:0050890 9.32 GNAS LHCGR
5 activation of adenylate cyclase activity GO:0007190 9.26 GNAS LHCGR
6 sterol metabolic process GO:0016125 9.16 CYP19A1 CYP21A2
7 positive regulation of cAMP-mediated signaling GO:0043950 8.62 GNAS LHCGR

Molecular functions related to Precocious Puberty according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hydroxylase activity GO:0008395 8.96 CYP19A1 CYP21A2
2 G-protein coupled peptide receptor activity GO:0008528 8.62 KISS1R LHCGR

Sources for Precocious Puberty

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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