MCID: PRC019
MIFTS: 61

Precocious Puberty malady

Endocrine, Genetic categories

Summaries for Precocious Puberty

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Precocious puberty is when a person's sexual and physical traits develop and mature earlier than normal. normal puberty typically begins between ages 10 and 14 for girls, and ages 12 and 16 for boys. the start of puberty depends on various factors such as family history, nutrition and gender. the cause of precocious puberty is not always known. some cases of precocious puberty are due to conditions that cause changes in the body's release of hormones. treatment involves medications that can stop the release of sexual hormones. last updated: 12/21/2012

MalaCards: Precocious Puberty, also known as cryptogenic sexual precocity, is related to precocious puberty, male and mccune albright syndrome. An important gene associated with Precocious Puberty is LHCGR (luteinizing hormone/choriogonadotropin receptor), and among its related pathways are Regulation of Insulin Secretion and Gastric acid secretion. The drugs gonadorelin and gonadorelin acetate and the compounds nafarelin and buserelin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Wikipedia:64 In medicine, precocious puberty is puberty occurring at an unusually early age. In most of these... more...

Aliases & Classifications for Precocious Puberty

Sources:
43NIH Rare Diseases, 22GTR, 61UMLS, 45Novoseek, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Endocrine


Aliases & Descriptions:

precocious puberty 43 22 61
cryptogenic sexual precocity 61
familial precocious puberty 43
idiopathic sexual precocity 43
puberty precocious 45
sexual precocity 43


External Ids:

ICD1025 E30.1

Related Diseases for Precocious Puberty

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Precocious Puberty family:

central precocious puberty precocious puberty, central, 2
precocious puberty, central, 1

Diseases related to Precocious Puberty via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1precocious puberty, male31.3LHCGR, FSHR, CYP19A1
2mccune albright syndrome31.2GNRH1, ADCY2
3klinefelter's syndrome30.8KISS1, CYP19A1, KISS1R, GNRH1, CYP21A2, NR0B1
4growth hormone deficiency30.7IGF1, LSL
5polycystic ovary syndrome30.7CYP21A2, LSL, CYP19A1, FSHR, GNRH1, IGF1
6hyperandrogenism30.7FSHR, CYP21A2, CYP19A1, IGF1, GNRH1, LSL
7congenital adrenal hyperplasia30.6CYP21A2, CYP19A1, NR0B1, GNRH1, LSL
8adenoma30.6ADCY1, NR0B1, LHCGR, GNRH1, IGF1, CYP21A2
9turner syndrome30.4GNRH1, IGF1
10adrenal adenoma30.3NR0B1, CYP19A1, CYP21A2
11short stature30.3CYP19A1, CYP21A2, IGF1, GNRH1, NR0B1
12amenorrhea30.1FSHR, IGF1, GNRH1
13gynecomastia30.1CYP19A1, GNRH1
14hyperprolactinemia30.1GNRH1, IGF1
15insulin resistance30.1CYP21A2, IGF1, LSL
16adrenocortical carcinoma30.1CYP21A2, CYP19A1, NR0B1
17cushing's syndrome30.1CYP21A2, NR0B1, GNRH1, LSL, LHCGR, IGF1
18infertility30.1FSHR, CYP21A2, CYP19A1, GNRH1, LSL, LHCGR
19central precocious puberty11.3
20idiopathic central precocious puberty10.9
21familial male-limited precocious puberty10.8
22mccune–albright syndrome10.8
23testotoxicosis10.6
24peripheral precocious puberty10.6
25precocious puberty, gonadotropin-dependent10.6
26precocious puberty, central, 110.6
27spastic paraplegia with precocious puberty10.6
28precocious puberty, central, 210.6
29hypothalamic hamartomas10.6
30germinoma10.5
31n syndrome10.5
32teratoma10.4
33neurofibromatosis10.4
34prader-willi syndrome10.4
35empty sella syndrome10.3
36young syndrome10.3
37pineal cyst10.3
38epidermal nevus10.3
39secondary central precocious puberty10.3
40mixed germ cell tumor10.3
41intellectual deficit, x-linked - precocious puberty - obesity10.3
42narcolepsy10.2
43tuberous sclerosis10.2
44gonadoblastoma10.2
45congenital hypothyroidism10.2
46proteus syndrome10.2
47sertoli cell tumor10.2
48rickets10.2
49fibrous dysplasia10.2
50down syndrome10.2

Graphical network of the top 20 diseases related to Precocious Puberty:



Diseases related to precocious puberty

Clinical Features for Precocious Puberty

Drugs & Therapeutics for Precocious Puberty

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Precocious Puberty

Drug clinical trials:

Search ClinicalTrials for Precocious Puberty

Search NIH Clinical Center for Precocious Puberty

Search CenterWatch for Precocious Puberty

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Precocious Puberty

Sources:
22GTR
See all sources

Genetic tests related to Precocious Puberty:

id Genetic test Affiliating Genes
1 Precocious Puberty22

Anatomical Context for Precocious Puberty

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Precocious Puberty:

33
Brain, Spinal cord, Heart, Pancreas, Thyroid, Adrenal gland, Breast, Skin, Ovary, Prostate, Testis, T cells, B lymphoblasts, B cells, Hypothalamus, Pineal, Pituitary, Testis germ, Testis leydig

Animal Models for Precocious Puberty or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Precocious Puberty

Sources:
51PubMed
See all sources

Articles related to Precocious Puberty:

(show top 50)    (show all 736)
idTitleAuthorsYear
1
Hypertension during therapy with triptorelin in a girl with precocious puberty. (23180401)
2013
2
Precocious puberty produced by an osteolipoma of the tuber cinereum. (23329765)
2012
3
Causes and types of precocious puberty in north-west iran. (23430037)
2012
4
A single sample GnRHa stimulation test in the diagnosis of precocious puberty. (22809285)
2012
5
GnRH stimulation test in precocious puberty: single sample is adequate for diagnosis and dose adjustment. (21448328)
2011
6
Precocious puberty in an infant with hepatoblastoma: a case report. (21878089)
2011
7
Precocious puberty and pineal cyst--an uncommon association. (20228436)
2010
8
Results of a second year of therapy with the 12-month histrelin implant for the treatment of central precocious puberty. (19956699)
2009
9
Tetrasomy 13q mosaicism associated with phylloid hypomelanosis and precocious puberty. (19334087)
2009
10
Utility of breast ultrasonography in the diagnostic work-up of precocious puberty and proposal of a prognostic index for identifying girls with rapidly progressive central precocious puberty. (19086040)
2009
11
A CDKL5 mutated child with precocious puberty. (19396824)
2009
12
Peripheral precocious puberty: a retrospective study for six years in Hangzhou, China. (18564081)
2008
13
Clinical practice. Precocious puberty. (18509122)
2008
14
Central precocious puberty due to hypothalamic hamartoma in a 7-month-old infant girl. (17541635)
2008
15
A familial dysmorphic condition with hypotonia, seizures and precocious puberty. (18541960)
2008
16
An infant case of macroprolactinemia with transient idiopathic central precocious puberty. (17785914)
2007
17
An update on the treatment of precocious puberty in McCune-Albright syndrome and testotoxicosis. (17663289)
2007
18
Narcolepsy-cataplexy associated with precocious puberty. (16717224)
2006
19
An unusual case of chromosome 22q11 deletion syndrome with psychiatric disorder, hypoparathyroidism and precocious puberty. (16789644)
2006
20
High incidence of central precocious puberty in a bounded geographic area of northwest Tuscany: an estrogen disrupter epidemic? (15823828)
2005
21
Precocious puberty at an endocrine centre in Jordan. (15379758)
2004
22
Cranial MRI scans are indicated in all girls with central precocious puberty. (12716713)
2003
23
Congenital HIV infection and precocious puberty. (12880131)
2003
24
Ovarian and uterine findings in pelvic sonography: comparison between prepubertal girls, girls with isolated thelarche, and girls with central precocious puberty. (12418765)
2002
25
Central precocious puberty in multisystem Langerhans cell histiocytosis: a case report. (12051595)
2002
26
Factors predicting adult height in girls with idiopathic central precocious puberty: implications for treatment. (11940040)
2002
27
Age of puberty among girls and the diagnosis of precocious puberty. (11403073)
2001
28
Follow-up of children and young adults after GnRH-agonist therapy or central precocious puberty. (11716160)
2001
29
Precocious puberty in a girl with congenital hypothyroidism receiving continuous L-thyroxine-replacement therapy. (11208009)
2001
30
Gonadotropin-independent precocious puberty due to luteinizing hormone receptor mutations in Brazilian boys: a novel constitutively activating mutation in the first transmembrane helix. (11134146)
2000
31
Prospective assessment of pituitary size and shape on MR imaging after suppressive hormonal therapy in central precocious puberty. (10929361)
2000
32
Diagnosis of central precocious puberty: endocrine assessment. (10969913)
2000
33
Final height after gonadotrophin releasing hormone agonist treatment for central precocious puberty: the Dutch experience. (10969919)
2000
34
Etiology of central precocious puberty in males: the results of the Italian Study Group for Physiopathology of Puberty. (10969910)
2000
35
Mutation analysis of the follicle-stimulating hormone receptor gene in girls with gonadotropin-independent precocious puberty resulting from autonomous cystic ovaries. (10685529)
2000
36
Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty. (10599706)
1999
37
Central precocious puberty in 48,XXYY Klinefelter syndrome variant. (10821227)
1999
38
Beneficial effects of dietary supplementation in a disorder with defective synthesis of cholesterol. A case report of a girl with Smith-Lemli-Opitz syndrome, polyneuropathy and precocious puberty. (10447131)
1999
39
Adult height comparison between boys and girls with precocious puberty after long-term gonadotrophin-releasing hormone analogue therapy. (9641733)
1998
40
High prevalence of abnormal adrenal response in girls with central precocious puberty at early pubertal stages. (7581962)
1995
41
Congenital adrenal hyperplasia complicated by central precocious puberty: treatment with LHRH-agonist analogue. (8323180)
1993
42
Neurosurgical treatment of hypothalamic hamartomas causing precocious puberty. (8416246)
1993
43
Height prognosis of children with true precocious puberty and growth hormone deficiency: effect of combination therapy with gonadotropin releasing hormone agonist and growth hormone. (1533661)
1992
44
Long-term results of long-acting luteinizing-hormone-releasing hormone agonist in central precocious puberty. (1840142)
1991
45
Long-term results with a slow-release gonadotrophin-releasing hormone agonist in central precocious puberty. Dutch-German Precocious Puberty Study Group. (1833950)
1991
46
Bone loss during gonadotropin-releasing hormone agonist treatment in girls with true precocious puberty is not due to an impairment of calcitonin secretion. (1830057)
1991
47
Idiopathic central precocious puberty in girls as a model of the effect of plasma estradiol level on growth, skeletal maturation and plasma insulin-like growth factor I. (1818007)
1991
48
Precocious puberty in a boy with a PRL-, LH- and FSH-secreting pituitary tumour: hormonal and immunocytochemical studies. (2112813)
1990
49
Treatment of central precocious puberty with an LHRH agonist (Buserelin): effect on growth and bone maturation after three years of treatment. (2969858)
1987
50
Spontaneous gonadotrophin pulsatility and ovarian morphology in girls with central precocious puberty treated with cyproterone acetate. (2935331)
1985

Genetic Variations for Precocious Puberty

Expression for genes affiliated with Precocious Puberty

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Precocious Puberty

Search GEO for disease gene expression data for Precocious Puberty.

Pathways for genes affiliated with Precocious Puberty

Sources:
54Reactome, 30KEGG, 50PharmGKB, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore
See all sources

Pathways related to Precocious Puberty according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1ADCY2, ADCY3, ADCY9, ADCY7, ADCY5, ADCY6
2
Hide members
10.1ADCY3, ADCY6, ADCY2, ADCY7, ADCY9, ADCY5
3
Hide members
10.1ADCY6, ADCY2, ADCY3, ADCY1, ADCY8, ADCY7
4
Hide members
10.1ADCY5, ADCY1, ADCY8, ADCY9, ADCY6, ADCY3
5
Hide members
10.1ADCY3, ADCY5, ADCY9, ADCY6, ADCY7, ADCY1
6
Hide members
10.1ADCY8, ADCY5, ADCY9, ADCY2, ADCY6, ADCY3
710.1ADCY1, ADCY3, ADCY9, LHCGR, ADCY7, ADCY4
8
Hide members
10.0ADCY6, ADCY3, ADCY7, ADCY2, ADCY9, ADCY5
910.0ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
1010.0ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
11
G-protein signaling G-Protein alpha-i signaling cascades
Hide members
10.0ADCY6, ADCY3, ADCY7, ADCY2, ADCY9, ADCY5
1210.0ADCY6, ADCY3, ADCY7, ADCY4, ADCY8, ADCY1
13
Hide members
10.0ADCY6, ADCY3, ADCY7, ADCY2, ADCY9, ADCY5
1410.0ADCY7, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9
1510.0ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
16
Hide members
10.0ADCY6, ADCY2, ADCY9, ADCY7, ADCY1, ADCY4
1710.0ADCY7, ADCY2, ADCY6, ADCY3, ADCY8, ADCY5
18
Hide members
10.0ADCY3, ADCY2, ADCY9, ADCY4, ADCY6, ADCY5
19
Hide members
10.0ADCY2, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9
20
Hide members
10.0ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
21
Hide members
10.0ADCY7, ADCY3, ADCY4, ADCY8, ADCY1, ADCY5
2210.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
2310.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
24
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
10.0ADCY6, ADCY3, ADCY4, ADCY8, ADCY1, ADCY5
2510.0ADCY7, ADCY3, ADCY6, ADCY4, ADCY8, ADCY1
26
Signal transduction cAMP signaling
Hide members
10.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
2710.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
28
Hide members
10.0ADCY8, ADCY5, ADCY2, ADCY1, ADCY6, ADCY7
2910.0ADCY8, ADCY2, ADCY9, ADCY6, ADCY3, ADCY7
3010.0ADCY3, ADCY6, ADCY2, ADCY9, ADCY1, ADCY8
31
Hide members
10.0ADCY4, ADCY8, ADCY2, ADCY1, ADCY5, ADCY9
32
Hide members
10.0ADCY6, ADCY2, ADCY9, ADCY8, ADCY4, ADCY1
33
Hide members
10.0ADCY1, ADCY5, ADCY9, ADCY2, ADCY6, ADCY3
34
Hide members
10.0ADCY7, ADCY6, ADCY2, ADCY3, ADCY5, ADCY1
3510.0ADCY4, ADCY6, ADCY7, ADCY2, ADCY9, ADCY5
36
Hide members
10.0ADCY1, ADCY8, ADCY7, ADCY4, ADCY5, ADCY9
37
Development Endothelin-1/EDNRA signaling
Hide members
10.0GNRH1, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
38
Hide members
10.0ADCY9, ADCY8, ADCY1, ADCY2, GNRH1, ADCY3
39
Hide members
10.0ADCY6, ADCY2, ADCY9, ADCY5, ADCY1, ADCY4
40
Hide members
10.0ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
41
Hide members
9.9ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
42
Hide members
9.9ADCY8, ADCY3, ADCY1, ADCY7, ADCY6, IGF1
43
Hide members
9.9ADCY9, ADCY8, ADCY1, ADCY6, ADCY3, ADCY7
44
Hide members
9.9ADCY3, ADCY2, ADCY1, ADCY5, ADCY9, ADCY4
45
Hide members
9.9ADCY9, ADCY8, ADCY1, ADCY4, ADCY2, ADCY6
46
Hide members
9.9IGF1, ADCY7, ADCY3, GNRH1, ADCY2, ADCY8
47
Hide members
9.9LHCGR, GNRH1, ADCY5, ADCY1, ADCY9, ADCY2
48
Hide members
9.9ADCY8, ADCY6, ADCY1, ADCY5, ADCY2, ADCY9
499.8ADCY4, ADCY8, LHCGR, IGF1, CYP19A1, ADCY1
50
Hide members
9.8ADCY8, LHCGR, ADCY1, ADCY5, KISS1, GNRH1

Compounds for genes affiliated with Precocious Puberty

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Precocious Puberty according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1nafarelin45 60 29 1113.7GNRH1, CYP19A1, CYP21A2
2buserelin45 29 1112.7LHCGR, GNRH1, IGF1, CYP19A1
3goserelin45 29 1112.7CYP19A1, GNRH1, LSL, LHCGR
4leuprolide acetate4510.7GNRH1, IGF1, CYP19A1, CYP21A2, LHCGR
5cetrorelix45 29 1112.6GNRH1, LHCGR, IGF1
6leuprolide45 60 29 1113.6LSL, GNRH1, IGF1
7clomiphene citrate4510.6GNRH1, IGF1, CYP19A1, CYP21A2
8Menotropins1110.6FSHR, LHCGR
9raloxifene45 29 50 1113.6IGF1, LSL, CYP19A1, GNRH1
10forskolin45 50 1112.6ADCY5, LHCGR, ADCY7, ADCY3, ADCY2, ADCY9
11dehydroepiandrosterone sulfate4510.6CYP21A2, CYP19A1, IGF1, LSL, GNRH1
12metformin45 50 1112.6IGF1, GNRH1, CYP19A1, LSL
13Choriogonadotropin alfa1110.6FSHR, LHCGR
14dhea4510.6LSL, CYP21A2, CYP19A1, IGF1
15androstenedione45 2411.6GNRH1, CYP21A2, CYP19A1, FSHR, LSL, IGF1
16progestin4510.6LHCGR, IGF1, GNRH1, CYP19A1
17tibolone4510.5GNRH1, LSL, CYP19A1
18isoproterenol45 1111.5ADCY1, ADCY7, GNRH1, LHCGR, ADCY3, ADCY2
19acth4510.5CYP21A2, NR0B1, LHCGR, ADCY1, IGF1, GNRH1
20ribonucleic acid4510.5GNRH1, IGF1, FSHR, CYP21A2, LHCGR
21estrone45 29 11 2413.5GNRH1, CYP19A1, IGF1, LSL
2217-hydroxyprogesterone45 2411.5GNRH1, CYP21A2, CYP19A1
23estradiol45 11 2412.5CYP19A1, IGF1, LHCGR, LSL, GNRH1, FSHR
24nkh 4776010.5ADCY4, ADCY8, ADCY5, ADCY9, ADCY2, ADCY6
25kh 76010.5ADCY5, ADCY9, ADCY2, ADCY6, ADCY3, ADCY7
26pacap 1-276010.5ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
27adenylate4510.5ADCY2, LHCGR, ADCY6, FSHR, ADCY3, ADCY9
28Pyruvic acid11 2411.5ADCY7, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9
29sq 2253660 4511.5ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
30dopamine45 29 11 2413.5ADCY1, ADCY2, GNRH1, IGF1, ADCY6, ADCY5
31mdl 12330a hydrochloride6010.5ADCY4, ADCY8, ADCY3, ADCY1, ADCY5, ADCY9
32nad29 2411.5ADCY3, ADCY7, ADCY6, ADCY9, ADCY5, ADCY1
33phosphoric acid45 2411.4ADCY9, ADCY4, ADCY8, ADCY1, ADCY7, ADCY3
34nadh45 11 2412.4ADCY4, ADCY8, ADCY1, ADCY9, ADCY7, ADCY3
35pyrophosphate45 2411.4ADCY2, ADCY9, ADCY5, ADCY1, ADCY6, ADCY3
36gnrh4510.4IGF1, CYP19A1, CYP21A2, FSHR, KISS1R, KISS1
37flutamide45 60 1112.4GNRH1, CYP19A1, LHCGR
38testosterone45 60 11 2413.4KISS1, FSHR, CYP19A1, LHCGR, GNRH1, LSL
39steroid4510.4FSHR, KISS1, CYP21A2, CYP19A1, IGF1, NR0B1
40fmpp4510.4FSHR, LHCGR
41arginine4510.4ADCY1, LHCGR, LSL, GNRH1, IGF1, CYP19A1
42Adenosine triphosphate11 2411.4ADCY4, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
43progesterone45 60 29 11 2414.4GNRH1, IGF1, LSL, LHCGR, NR0B1, FSHR
44hydrocortisone45 2 60 1113.4CYP19A1, CYP21A2, LSL, IGF1
45magnesium45 11 2412.4ADCY2, ADCY6, ADCY3, ADCY7, ADCY9, ADCY5
46cyclic amp45 2411.3ADCY3, ADCY1, ADCY5, ADCY2, LHCGR, NR0B1
472',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE1110.3ADCY2, ADCY5
48thyroxine45 2411.3CYP21A2, IGF1, GNRH1, LSL
49calcium45 50 11 2413.2ADCY6, ADCY2, ADCY3, ADCY7, ADCY5, KISS1
50dihydrotestosterone45 29 11 2413.0CYP21A2, CYP19A1, IGF1, GNRH1

GO Terms for genes affiliated with Precocious Puberty

Sources:
16Gene Ontology
See all sources

Cellular components related to Precocious Puberty according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:01602010.2CYP19A1, ADCY6, ADCY2, ADCY8, ADCY4, NR0B1
2plasma membraneGO:0058869.5ADCY4, LHCGR, IGF1, FSHR, KISS1R, ADCY7

Biological processes related to Precocious Puberty according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1sterol metabolic processGO:01612510.4CYP19A1, CYP21A2
2prostate gland growthGO:06073610.4CYP19A1, IGF1
3adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718910.4ADCY8, ADCY1, ADCY5, ADCY9, ADCY2, ADCY6
4cAMP biosynthetic processGO:00617110.4ADCY4, ADCY1, ADCY2, ADCY6
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.4ADCY9, ADCY2, ADCY6, ADCY3, ADCY7, ADCY5
6activation of phospholipase C activityGO:00720210.3ADCY4, ADCY8, ADCY1, ADCY5, ADCY9, ADCY2
7activation of protein kinase A activityGO:03419910.3ADCY3, ADCY6, ADCY2, ADCY7, ADCY4, ADCY8
8cellular response to glucagon stimulusGO:07137710.3ADCY7, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9
9energy reserve metabolic processGO:00611210.3ADCY9, ADCY7, ADCY3, ADCY6, ADCY1, ADCY5
10water transportGO:00683310.3ADCY4, ADCY9, ADCY7, ADCY3, ADCY6, ADCY2
11fibroblast growth factor receptor signaling pathwayGO:00854310.3ADCY6, ADCY7, ADCY1, ADCY4, ADCY8, ADCY5
12epidermal growth factor receptor signaling pathwayGO:00717310.3ADCY7, ADCY4, ADCY8, ADCY1, ADCY9, ADCY5
13intracellular signal transductionGO:03555610.3ADCY2, ADCY8, ADCY9, ADCY7, ADCY5, ADCY1
14neurotrophin TRK receptor signaling pathwayGO:04801110.3ADCY9, ADCY7, ADCY3, ADCY6, ADCY8, ADCY1
15male gonad developmentGO:00858410.2NR0B1, LHCGR, FSHR
16synaptic transmissionGO:00726810.2ADCY7, ADCY3, ADCY2, ADCY4, ADCY9, ADCY5
17transmembrane transportGO:05508510.2ADCY8, ADCY1, ADCY5, ADCY9, ADCY6, ADCY3
18innate immune responseGO:04508710.2ADCY6, ADCY4, ADCY8, ADCY1, ADCY5, ADCY9
19positive regulation of synaptic transmissionGO:05080610.1KISS1, KISS1R
20signal transductionGO:00716510.1ADCY5, IGF1, ADCY7, ADCY3, ADCY6, ADCY2
21small molecule metabolic processGO:04428110.0ADCY4, ADCY8, ADCY6, ADCY1, ADCY5, CYP21A2

Molecular functions related to Precocious Puberty according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase bindingGO:00817910.4ADCY2, ADCY5
2calcium- and calmodulin-responsive adenylate cyclase activityGO:00829410.3ADCY2, ADCY1, ADCY8
3adenylate cyclase activityGO:00401610.1ADCY4, ADCY7, ADCY3, ADCY6, ADCY2, ADCY9
4ATP bindingGO:0055249.9ADCY7, ADCY3, ADCY6, ADCY2, ADCY4, ADCY8
5metal ion bindingGO:0468729.7ADCY6, ADCY3, ADCY2, ADCY9, ADCY5, ADCY1

Products for genes affiliated with Precocious Puberty

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Precocious Puberty

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet