MCID: PRC049
MIFTS: 40

Precursor T-Cell Acute Lymphoblastic Leukemia malady

Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories

Aliases & Classifications for Precursor T-Cell Acute Lymphoblastic Leukemia

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Sources:
48Orphanet, 61UMLS, 26ICD10 via Orphanet
See all sources

Aliases & Descriptions for Precursor T-Cell Acute Lymphoblastic Leukemia:

Name: Precursor T-Cell Acute Lymphoblastic Leukemia 48
Precursor T-Cell Acute Lymphoblastic Leukemia/lymphoma 48
Precursor T-Cell Acute Lymphocytic Leukemia/lymphoma 48
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 61
 
Precursor T-Cell Acute Lymphocytic Leukemia 48
Adult T-Cell Lymphoma/leukemia 61
T-All 48


Classifications:



External Ids:

Orphanet48 99861
ICD10 via Orphanet26 C91.0

Summaries for Precursor T-Cell Acute Lymphoblastic Leukemia

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MalaCards based summary: Precursor T-Cell Acute Lymphoblastic Leukemia, also known as precursor t-cell acute lymphoblastic leukemia/lymphoma, is related to lymphoblastic leukemia and lymphoblastic lymphoma. An important gene associated with Precursor T-Cell Acute Lymphoblastic Leukemia is TLX1 (T-cell leukemia homeobox 1), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and Cytokines and Inflammatory Response. The compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and bone, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Related Diseases for Precursor T-Cell Acute Lymphoblastic Leukemia

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Diseases in the Precursor B-Cell Acute Lymphoblastic Leukemia family:

precursor t-cell acute lymphoblastic leukemia

Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoblastic leukemia32.3TLX1
2lymphoblastic lymphoma31.3TAL1, TRB
3prolymphocytic leukemia30.3MYC, TCL1A
4t-cell leukemia30.0MYB, TAL1, TCL1A, MYC, TLX1
5hodgkin lymphoma30.0TRB, BCR, TCL1A, FLT3
6myeloid leukemia29.7FLT3, PICALM, TRB, BCR, ABL1, MLLT10
7acute leukemia29.2ABL1, TRB, FLT3, TRD, TAL1, BCR
8leukemia28.8MYB, FLT3, TLX1, TLX3, MLLT10, PICALM
9laryngitis10.6
10acute biphenotypic leukemia10.4
11thymoma10.4
12bone marrow necrosis10.4
13bone marrow cancer10.3FLT3, ABL1
14primary effusion lymphoma10.3TCL1A, MYC
15thyroid lymphoma10.3PICALM
16neuroectodermal tumor10.3MYC, MYB
17chronic myelomonocytic leukemia10.3FLT3, BCR
18gastrointestinal stromal tumor10.3ABL1, BCR, FLT3
19burkitt lymphoma10.2TCL1A, TRG
20myelodysplastic syndrome10.2TRB, ABL1, TRA, FLT3
21peripheral t-cell lymphoma10.2TRG, TCL1A, TRB
22wilms tumor10.1MYB, ABL1, FLT3
23acute erythroid leukemia10.1TAL1, MYC, MYB
24squamous cell carcinoma, head and neck10.1CDKN2A, MYC, ABL1
25diabetes mellitus, insulin-dependent10.1TRB, TRA, TRG
26myeloma10.1MYC, TCL1A, BCR, TRB
27cutaneous t cell lymphoma10.1MYB, TRB, TRG
28chromosomal triplication10.1BCR, TRB, FLT3, MYC
29cervical cancer, somatic10.1MYB, CDKN2A, MYC
30follicular lymphoma10.1MYB, BCR, TCL1A, MYC
31glioblastoma10.1CDKN2A, MYC, ABL1, MYB
32precursor b-cell acute lymphoblastic leukemia10.0BCR, FLT3, ABL1, CDKN2A, MYC
33retinoblastoma10.0MYC, BCR, ABL1, MYB, CDKN2A
34deficiency anemia10.0ABL1, FLT3, MYB
35acute lymphoblastic leukemia, childhood10.0FLT3, TLX1, ABL1, TRD, BCR, CDKN2A
36ipex syndrome10.0TRB, TRA, MYB, FLT3, BCR
37rheumatoid arthritis9.9MYB, TRD, TRA, TRG, TRB
38ataxia-telangiectasia9.9
39hemolytic anemia9.9
40sinusitis9.9
41langerhans-cell histiocytosis9.9
42neurofibromatosis9.9
43cleft lip9.9
44autoimmune hemolytic anemia9.9
45acute t cell leukemia9.9
46pancytopenia9.9
47histiocytosis9.9
48prostatitis9.9
49sarcoma9.9
50ataxia9.9

Graphical network of the top 20 diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia:



Diseases related to precursor t-cell acute lymphoblastic leukemia

Symptoms for Precursor T-Cell Acute Lymphoblastic Leukemia

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Drugs & Therapeutics for Precursor T-Cell Acute Lymphoblastic Leukemia

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FDA approved drugs:

id Drug Name Active Ingredient(s)13 Pharmaceutical Company Approval Date
1
Arranon13 38 NELARABINE GlaxoSmithKline Approved October 2005
FDA Label: Arranon
Malady that Drug Treats: Lymphoblastic Leukemia
Indications and Usage:13 ARRANON is a nucleoside metabolic inhibitor indicated for the treatment of; patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic; lymphoma whose disease has not responded to or has relapsed following; treatment with at least two chemotherapy regimens. This use is based on the; induction of complete responses. Randomized trials demonstrating increased; survival or other clinical benefit have not been conducted. (1)
DrugBank Targets:11 DNA
Mechanism of Action:13 
Target: DNA synthesis
Action: disruptor --> apoptosis
FDA: Nelarabine is a pro-drug of the deoxyguanosine analogue 9-²-D-arabinofuranosylguanine; 266 (ara-G), a nucleoside metabolic inhibitor. Nelarabine is demethylated by adenosine deaminase; 267 (ADA) to ara-G, mono-phosphorylated by deoxyguanosine kinase and deoxycytidine kinase, and; 268 subsequently converted to the active 5 -triphosphate, ara-GTP. Accumulation of ara-GTP in; 269 leukemic blasts allows for incorporation into deoxyribonucleic acid (DNA), leading to inhibition; 270 of DNA synthesis and cell death. Other mechanisms may contribute to the cytotoxic and; 271 systemic toxicity of nelarabine.

Drug clinical trials:

Search ClinicalTrials for Precursor T-Cell Acute Lymphoblastic Leukemia

Search NIH Clinical Center for Precursor T-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Precursor T-Cell Acute Lymphoblastic Leukemia

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Anatomical Context for Precursor T-Cell Acute Lymphoblastic Leukemia

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MalaCards organs/tissues related to Precursor T-Cell Acute Lymphoblastic Leukemia:

31
T cells, Bone marrow, Bone, Cervix, Myeloid, Appendix

Animal Models for Precursor T-Cell Acute Lymphoblastic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Precursor T-Cell Acute Lymphoblastic Leukemia:

35 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8TLX3, FLT3, MYC, CDKN2A, TRD, TRB
2MP:00053708.5ABL1, PICALM, MYB, MYC, BCR, CDKN2A
3MP:00028738.4TRG, TRB, BCR, MYC, MYB, ABL1
4MP:00053858.4ABL1, MYB, MYC, CNOT3, TAL1, TRD
5MP:00036318.2ABL1, TLX3, TLX1, MYC, STIL, BCR
6MP:00053808.1ABL1, PICALM, TLX1, MYB, MYC, STIL
7MP:00053818.1ABL1, TLX3, MYC, BCR, CDKN2A, TRD
8MP:00107717.8TLX3, MYB, MYC, TAL1, CDKN2A, TRD
9MP:00053787.7ABL1, PICALM, FLT3, MYB, MYC, STIL
10MP:00053767.7ABL1, PICALM, TLX3, FLT3, MYC, BCR
11MP:00107686.9MYB, FLT3, TLX3, PICALM, ABL1, MYC
12MP:00053976.9MYB, FLT3, TLX1, PICALM, ABL1, MYC
13MP:00053846.8MYB, FLT3, TLX1, PICALM, ABL1, MYC
14MP:00053876.5TRG, ABL1, PICALM, TLX3, TLX1, FLT3

Publications for Precursor T-Cell Acute Lymphoblastic Leukemia

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Articles related to Precursor T-Cell Acute Lymphoblastic Leukemia:

(show all 14)
idTitleAuthorsYear
1
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. (25624896)
2015
2
NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia. (23349303)
2013
3
Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report. (23057758)
2012
4
Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder. (22184539)
2011
5
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. (18722237)
2008
6
A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia. (17498558)
2007
7
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
8
Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. (16493618)
2006
9
An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma. (15843931)
2005
10
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. (14983942)
2004
11
ABL oncogene amplification with p16(INK4a) gene deletion in precursor T-cell acute lymphoblastic leukemia/lymphoma: report of the first case. (15282669)
2004
12
Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix. (12004362)
2002
13
Precursor T-cell acute lymphoblastic leukemia in adults: age-related immunophenotypic, cytogenetic, and molecular subsets. (11863221)
2002
14
Orbital mass secondary to precursor T-cell acute lymphoblastic leukemia: a rare presentation. (11231781)
2001

Variations for Precursor T-Cell Acute Lymphoblastic Leukemia

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Expression for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Search GEO for disease gene expression data for Precursor T-Cell Acute Lymphoblastic Leukemia.

Pathways for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Pathways related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1BCR, ABL1
210.0TRA, TRB
39.9TRA, TRB, BCR
4
Show member pathways
DNA damage response36
9.8CDKN2A, MYC, ABL1
5
Show member pathways
9.8CDKN2A, MYC, ABL1
6
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.8CDKN2A, MYC, ABL1
79.8CDKN2A, MYC, ABL1
8
Show member pathways
Cell cycle36
9.8ABL1, MYC, CDKN2A
9
Show member pathways
Immune response IL 22 signaling pathway59
G protein signaling N RAS regulation pathway59
9.7TRA, TRB, MYC
109.7ABL1, FLT3, BCR
11
Show member pathways
9.6ABL1, MYC, BCR, CDKN2A
129.2ABL1, FLT3, MYC, BCR, CDKN2A
139.2TLX3, TLX1, FLT3, MYC

Compounds for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Compounds related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 34)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate5010.4BCR, ABL1
2nilotinib50 1111.4ABL1, BCR
3bgl ii4410.4TRB, BCR
4homoharringtonine44 50 1112.4BCR, ABL1
5tachyplesin i4410.3MYC, CDKN2A
6busulfan44 50 1112.3ABL1, BCR, CDKN2A
7hind iii4410.2TRB, BCR
8bamhi4410.2BCR, TRB, TRA
9aclarubicin4410.1MYB, MYC
10ponatinib50 1111.1BCR, FLT3, ABL1
11camptothecin44 60 1112.0CDKN2A, MYC, ABL1
12hmba4410.0CDKN2A, MYC
13phosphorothioate449.9MYC, MYB
14daunorubicin44 50 1111.9CDKN2A, MYC, FLT3
15nitroblue tetrazolium449.9MYC, MYB
16phorbol449.8MYB, MYC, TRB
17ecori449.8TRB, MYB
18agarose449.8CDKN2A, MYC, FLT3
19dmso449.8BCR, MYC, MYB, ABL1
20herbimycin a44 6010.8ABL1, FLT3, MYC
21af 10449.7PICALM, MLLT10, TLX1
22cytarabine44 50 1111.6ABL1, FLT3, MYC, BCR, CDKN2A
235-aza-2deoxycytidine449.6FLT3, MYC, CDKN2A
24doxorubicin44 50 1111.5CDKN2A, MYC, MYB, FLT3
25imatinib44 50 1111.4BCR, MYC, MYB, FLT3, ABL1
26thymidine44 2410.4FLT3, MYB, MYC, BCR
27arsenite44 2410.3CDKN2A, MYC, FLT3
28vegf449.2ABL1, FLT3, MYB, MYC, TAL1, CDKN2A
29retinoic acid44 2410.1ABL1, FLT3, MYB, MYC, TAL1, CDKN2A
30serine449.0ABL1, MYB, MYC, TCL1A, BCR, TAL1
31tyrosine449.0ABL1, TLX1, FLT3, MYB, MYC, BCR
32leucine448.8PICALM, MLLT10, MYB, MYC, BCR, CDKN2A
33oligonucleotide448.6TRB, ABL1, TLX1, FLT3, MYB, MYC
34threonine448.6ABL1, TLX1, FLT3, MYB, MYC, TCL1A

GO Terms for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Cellular components related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056346.8CDKN2A, ABL1, PICALM, MLLT10, TLX3, TLX1

Biological processes related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:004800810.1BCR, ABL1
2regulation of stem cell maintenanceGO:0200003610.0TAL1, CNOT3
3peptidyl-tyrosine phosphorylationGO:00181089.6ABL1, FLT3, BCR
4regulation of endocytosisGO:00301009.5PICALM, ABL1
5hemopoiesisGO:00300979.4PICALM, FLT3, TAL1
6positive regulation of transcription, DNA-templatedGO:00458939.0CDKN2A, TAL1, MYC, MYB, PICALM
7positive regulation of transcription from RNA polymerase II promoterGO:00459448.3CDKN2A, DDX3X, MLLT10, TLX1, MYB, MYC

Molecular functions related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1E-box bindingGO:00708889.9TAL1, MYC
2sequence-specific DNA binding transcription factor activityGO:00037008.4MLLT10, TLX3, TLX1, MYB, MYC, TAL1
3DNA bindingGO:00036778.0DDX3X, ABL1, MLLT10, MYB, MYC, CDKN2A
4protein bindingGO:00055155.3CDKN2A, DDX3X, ABL1, PICALM, MLLT10, TLX3

Sources for Precursor T-Cell Acute Lymphoblastic Leukemia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet