T-ALL
MCID: PRC049
MIFTS: 41

Precursor T-Cell Acute Lymphoblastic Leukemia (T-ALL) malady

Categories: Blood diseases, Rare diseases, Immune diseases, Cancer diseases

Aliases & Classifications for Precursor T-Cell Acute Lymphoblastic Leukemia

Aliases & Descriptions for Precursor T-Cell Acute Lymphoblastic Leukemia:

Name: Precursor T-Cell Acute Lymphoblastic Leukemia 56
Precursor T-Cell Acute Lymphoblastic Leukemia/lymphoma 56
Precursor T-Cell Acute Lymphocytic Leukemia/lymphoma 56
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 69
Precursor T-Cell Acute Lymphocytic Leukemia 56
Adult T-Cell Lymphoma/leukemia 69
T-All 56

Classifications:



External Ids:

Orphanet 56 ORPHA99861
ICD10 via Orphanet 34 C91.0

Summaries for Precursor T-Cell Acute Lymphoblastic Leukemia

MalaCards based summary : Precursor T-Cell Acute Lymphoblastic Leukemia, also known as precursor t-cell acute lymphoblastic leukemia/lymphoma, is related to leukemia, acute lymphoblastic and leukemia. An important gene associated with Precursor T-Cell Acute Lymphoblastic Leukemia is TRD (T-Cell Receptor Delta Locus), and among its related pathways/superpathways are Pathways in cancer and Transcriptional misregulation in cancer. The drugs Dexamethasone and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and bone, and related phenotypes are cellular and embryo

Related Diseases for Precursor T-Cell Acute Lymphoblastic Leukemia

Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
id Related Disease Score Top Affiliating Genes
1 leukemia, acute lymphoblastic 11.2
2 leukemia 10.5
3 lymphoblastic leukemia 10.5
4 lymphoma 10.3
5 necrotic uveal melanoma 10.1 FLT3 MLLT10 MYC
6 acute leukemia 10.1 FLT3 MLLT10
7 lymphoblastic lymphoma 10.1
8 laryngitis 10.1
9 pigmented purpuric dermatosis 10.1 ABL1 BCR
10 lymphoma, small cleaved-cell, diffuse 10.0 MYC TAL1 TRB
11 superior limbic keratoconjunctivitis 10.0 TRD TRG
12 macrostomia-preauricular tags-external ophthalmoplegia syndrome 10.0 ABL1 MYC TCL1A
13 acute biphenotypic leukemia 9.9
14 acute pancreatitis 9.9
15 thymoma 9.9
16 retinitis 9.9
17 pancreatitis 9.9
18 retinal detachment 9.9
19 myeloid leukemia 9.9
20 bone marrow necrosis 9.9
21 actinobacillosis 9.8 ABL1 BCR FLT3
22 hemophagocytic lymphohistiocytosis 9.8 ABL1 BCR FLT3 MLLT10 PICALM
23 anus basaloid carcinoma 9.7 TAL1 TCL1A TLX1 TLX3
24 milker's nodule 9.7 ABL1 BCR FLT3 MYC PICALM
25 peroxisome biogenesis disorder 7a 9.7 ABL1 BCR FLT3 MYB MYC
26 hyperphosphatasia with mental retardation syndrome 2 9.7 ABL1 BCR CDKN2A FLT3 MYC
27 adult acute lymphocytic leukemia 9.7 BCR CDKN2A TAL1 TLX3
28 cranioectodermal dysplasia 1 9.5 ABL1 BCR CDKN2A FLT3 MLLT10 MYB
29 liver disease 9.1 ABL1 BCR CDKN2A FLT3 MLLT10 TAL1
30 amblyopia 9.1 ABL1 BCR CDKN2A FLT3 MYC PICALM
31 phosphoserine phosphatase deficiency 8.5 ABL1 BCR CDKN2A FLT3 MLLT10 MYB
32 bifid uvula 7.8 ABL1 BCR CDKN2A CNOT3 DDX3X FLT3

Graphical network of the top 20 diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia:



Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia

Symptoms & Phenotypes for Precursor T-Cell Acute Lymphoblastic Leukemia

MGI Mouse Phenotypes related to Precursor T-Cell Acute Lymphoblastic Leukemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 BCR MYB CDKN2A MYC CNOT3 PICALM
2 embryo MP:0005380 10.07 MYB CDKN2A MYC CNOT3 PICALM DDX3X
3 growth/size/body region MP:0005378 10.06 ABL1 FLT3 BCR MYB CDKN2A MYC
4 hematopoietic system MP:0005397 9.96 BCR MYB CDKN2A MYC CNOT3 PICALM
5 immune system MP:0005387 9.9 BCR MYB CDKN2A MYC CNOT3 PICALM
6 liver/biliary system MP:0005370 9.5 BCR MYB CDKN2A MYC CNOT3 PICALM
7 mortality/aging MP:0010768 9.4 ABL1 FLT3 BCR MYB CDKN2A MYC

Drugs & Therapeutics for Precursor T-Cell Acute Lymphoblastic Leukemia

Drugs for Precursor T-Cell Acute Lymphoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 287)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
2
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
3
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
4
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
5
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
6
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
7
Teniposide Approved Phase 4,Phase 2 29767-20-2 34698
8
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
9
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
10
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
11
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
12
Ifosfamide Approved Phase 4,Phase 3,Phase 1,Phase 2 3778-73-2 3690
13
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
14
Thioguanine Approved Phase 4,Phase 3,Phase 2 154-42-7 2723601
15
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
16
Vindesine Approved Phase 4,Phase 3 59917-39-4, 53643-48-4 40839
17
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
18
Cladribine Approved, Investigational Phase 4,Phase 2 4291-63-8 20279
19
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
21
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
22 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1
23 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
24 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
26 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
27 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
30 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
32 Dexamethasone 21-phosphate Phase 4,Phase 3,Phase 2,Phase 1
33 Hormones Phase 4,Phase 3,Phase 2,Phase 1
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
36 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
37 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Phase 1
40 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1
41 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Phase 1
42 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
45 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
46 Isophosphamide mustard Phase 4,Phase 3,Phase 1,Phase 2
47 Antilymphocyte Serum Phase 4,Phase 3,Phase 2,Phase 1
48 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1
49 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
50 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 357)
id Name Status NCT ID Phase
1 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4
2 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4
3 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Recruiting NCT02290132 Phase 4
4 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
5 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4
6 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3
7 Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00707083 Phase 3
8 Standard Chemotherapy With or Without Nelarabine or Rituximab in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT01085617 Phase 3
9 Treatment of Acute Lymphoblastic Leukemia in Children Unknown status NCT00400946 Phase 3
10 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3
11 Treatment of Acute Lymphoblastic Leukemia (ALL) in Younger Adults Completed NCT00327678 Phase 3
12 Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma Completed NCT01230983 Phase 3
13 Study of Treatment High Risk and/or Low Risk Acute Lymphoblastic leukémia(ALL) Adults Stage III Completed NCT00483132 Phase 3
14 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy Completed NCT00816049 Phase 3
15 Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia Completed NCT00967057 Phase 3
16 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00613457 Phase 3
17 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3
18 Chronic Graft-versus-host Disease (cGvHD) Prophylaxis With or Without ATG Prior to Stem Cell Transplantation (SCT) From HLA-identical Siblings in Patients With Acute Leukemia Completed NCT00678275 Phase 3
19 Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma Completed NCT00002766 Phase 3
20 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3
21 Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00152139 Phase 3
22 Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications Completed NCT00799461 Phase 3
23 Haploidentical Stem Cell Transplantation for Patients With Hematologic Malignancies Completed NCT00186823 Phase 3
24 Clofarabine or High-Dose Cytarabine and Pegaspargase in Children With ALL Recruiting NCT01228331 Phase 2, Phase 3
25 Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment Recruiting NCT02881086 Phase 3
26 Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Recruiting NCT02112916 Phase 3
27 A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents Recruiting NCT02716233 Phase 3
28 Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma Recruiting NCT03117751 Phase 2, Phase 3
29 Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HR First Relapse B-precursor ALL Recruiting NCT02393859 Phase 3
30 Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies Recruiting NCT02566395 Phase 3
31 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Active, not recruiting NCT00408005 Phase 3
32 International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia Active, not recruiting NCT01117441 Phase 3
33 Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Active, not recruiting NCT00557193 Phase 3
34 Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission Active, not recruiting NCT00382109 Phase 3
35 Study of US-ATG-F to Prevent Chronic Graft Versus Host Disease (GVHD) Active, not recruiting NCT01295710 Phase 3
36 Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant Active, not recruiting NCT01231412 Phase 3
37 Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Not yet recruiting NCT03007147 Phase 3
38 Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents Not yet recruiting NCT03020030 Phase 3
39 Safety and Efficacy of ATIR101 as Adjunctive Treatment to Blood Stem Cell Transplantation From a Haploidentical Family Donor Compared to Post-transplant Cyclophosphamide in Patients With Blood Cancer Not yet recruiting NCT02999854 Phase 3
40 Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma Terminated NCT00275106 Phase 3
41 Efficacy and Safety of a Donor Lymphocyte Preparation Depleted of Functional Host Alloreactive T-cells (ATIR) in Patients Undergoing a Peripheral Blood Stem Cell Transplant From a Related, Haploidentical Donor Terminated NCT00967343 Phase 2, Phase 3
42 Combination Chemotherapy in Treating Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT01005758 Phase 2
43 Rituximab in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer Unknown status NCT01044745 Phase 2
44 Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2
45 Lenalidomide as Maintenance Therapy After Combination Chemotherapy With or Without Rituximab and Stem Cell Transplant in Treating Patients With Persistent or Recurrent Non-Hodgkin Lymphoma That is Resistant to Chemotherapy Unknown status NCT01035463 Phase 1, Phase 2
46 506U78 In Relapsed Or Refractory Acute Lymphoblastic Leukemia (T-ALL) Completed NCT00684619 Phase 2
47 Phase II Study of the BiTE® Blinatumomab (MT103) in Patients With Minimal Residual Disease of B-precursor Acute Lymphoblastic Leukemia (ALL) Completed NCT00560794 Phase 2
48 Clinical Study With Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia Completed NCT01471782 Phase 1, Phase 2
49 Treatment of Relapsed T-Cell Acute Lymphoblastic Leukemia or T-Lymphoblastic Lymphoma With MabCampath Completed NCT00199030 Phase 2
50 Study of the BiTE® Blinatumomab (MT103) in Adult Patients With Relapsed/Refractory B-Precursor Acute Lymphoblastic Leukemia (ALL) Completed NCT01209286 Phase 2

Search NIH Clinical Center for Precursor T-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Precursor T-Cell Acute Lymphoblastic Leukemia

Anatomical Context for Precursor T-Cell Acute Lymphoblastic Leukemia

MalaCards organs/tissues related to Precursor T-Cell Acute Lymphoblastic Leukemia:

39
T Cells, Bone Marrow, Bone, Appendix, Cervix, Myeloid

Publications for Precursor T-Cell Acute Lymphoblastic Leukemia

Articles related to Precursor T-Cell Acute Lymphoblastic Leukemia:

(show all 17)
id Title Authors Year
1
Secondary pancreatic involvement by precursor T-cell acute lymphoblastic leukemia presenting as acute pancreatitis. ( 26905170 )
2015
2
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. ( 25624896 )
2015
3
A 25-Year-Old Man with Exudative Retinal Detachments and Infiltrates without Hematological or Neurological Findings Found to Have Relapsed Precursor T-Cell Acute Lymphoblastic Leukemia. ( 26483676 )
2015
4
NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia. ( 23349303 )
2013
5
Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report. ( 23057758 )
2012
6
Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder. ( 22184539 )
2011
7
Gum hypertrophy - an unusual presenting feature in a case of precursor T-cell acute lymphoblastic leukemia. ( 27264925 )
2008
8
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. ( 18722237 )
2008
9
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. ( 17369128 )
2007
10
A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia. ( 17498558 )
2007
11
Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. ( 16493618 )
2006
12
An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma. ( 15843931 )
2005
13
ABL oncogene amplification with p16(INK4a) gene deletion in precursor T-cell acute lymphoblastic leukemia/lymphoma: report of the first case. ( 15282669 )
2004
14
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. ( 14983942 )
2004
15
Precursor T-cell acute lymphoblastic leukemia in adults: age-related immunophenotypic, cytogenetic, and molecular subsets. ( 11863221 )
2002
16
Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix. ( 12004362 )
2002
17
Orbital mass secondary to precursor T-cell acute lymphoblastic leukemia: a rare presentation. ( 11231781 )
2001

Variations for Precursor T-Cell Acute Lymphoblastic Leukemia

Expression for Precursor T-Cell Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for Precursor T-Cell Acute Lymphoblastic Leukemia.

Pathways for Precursor T-Cell Acute Lymphoblastic Leukemia

Pathways related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.32 ABL1 BCR CDKN2A FLT3 MYC
2 11.81 FLT3 MYC TLX1 TLX3
3 11.6 ABL1 CDKN2A MYC
4
Show member pathways
11.6 ABL1 BCR CDKN2A MYC
5 10.47 ABL1 CDKN2A MYC
6
Show member pathways
10.14 ABL1 CDKN2A MYC

GO Terms for Precursor T-Cell Acute Lymphoblastic Leukemia

Cellular components related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.8 ABL1 CDKN2A CNOT3 DDX3X FLT3 HNRNPH1
2 protein complex GO:0043234 9.1 ABL1 BCR FLT3 MLLT10 MYC TAL1

Biological processes related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.96 ABL1 CDKN2A CNOT3 DDX3X MLLT10 MYB
2 positive regulation of transcription, DNA-templated GO:0045893 9.85 CDKN2A MYB MYC PICALM TAL1
3 hemopoiesis GO:0030097 9.5 FLT3 PICALM TAL1
4 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.5 CDKN2A DDX3X MLLT10 MYB MYC TAL1
5 definitive hemopoiesis GO:0060216 9.43 BCR TAL1
6 regulation of stem cell population maintenance GO:2000036 9.4 CNOT3 TAL1
7 positive regulation of glial cell proliferation GO:0060252 9.37 MYB MYC
8 negative regulation of ubiquitin-protein transferase activity GO:0051444 9.16 ABL1 CDKN2A
9 positive regulation of neuron death GO:1901216 8.8 ABL1 MYB PICALM

Molecular functions related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.28 ABL1 CDKN2A DDX3X MLLT10 MYB MYC

Sources for Precursor T-Cell Acute Lymphoblastic Leukemia

3 CDC
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