T-ALL
MCID: PRC049
MIFTS: 44

Precursor T-Cell Acute Lymphoblastic Leukemia (T-ALL) malady

Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories

Summaries for Precursor T-Cell Acute Lymphoblastic Leukemia

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34MalaCards
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MalaCards: Precursor T-Cell Acute Lymphoblastic Leukemia, also known as precursor t-cell acute lymphoblastic leukemia/lymphoma, is related to lymphoblastic leukemia and lymphoblastic lymphoma. An important gene associated with Precursor T-Cell Acute Lymphoblastic Leukemia is TLX1 (T-cell leukemia homeobox 1), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and Cytokines and Inflammatory Response. The drug cyclophosphamide and the compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and bone, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Precursor T-Cell Acute Lymphoblastic Leukemia

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63UMLS, 50Orphanet, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

precursor t-cell acute lymphoblastic leukemia 50
precursor t-cell acute lymphoblastic leukemia/lymphoma 50
precursor t-cell acute lymphocytic leukemia/lymphoma 50
precursor t-cell acute lymphocytic leukemia 50
burkitt lymphoma 63
t-all 50


External Ids:

SNOMED-CT via Orphanet60 128824003
ICD10 via Orphanet27 C91.0

Related Diseases for Precursor T-Cell Acute Lymphoblastic Leukemia

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18GeneCards, 19GeneDecks
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Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoblastic leukemia31.3TLX1
2lymphoblastic lymphoma30.9TAL1, TRB
3leukemia30.4MYB, FLT3, TLX1, TLX3, MLLT10, PICALM
4prolymphocytic leukemia30.0MYC, TCL1A
5acute leukemia29.9ABL1, TRB, FLT3, TRD, TAL1, BCR
6t-cell leukemia29.9MYB, TAL1, TCL1A, MYC, TLX1
7thymoma10.4
8acute biphenotypic leukemia10.4
9bone marrow necrosis10.4
10bone marrow cancer10.1FLT3, ABL1
11lymphoma aidsrelated10.1TCL1A, MYC
12thyroid lymphoma10.1PICALM
13neuroepithelioma10.1MYC, MYB
14chronic myelomonocytic leukemia10.1FLT3, BCR
15gastrointestinal stromal tumor10.1ABL1, BCR, FLT3
16myeloproliferative disorder10.0TRB, ABL1, FLT3, BCR
17burkitt's lymphoma10.0TCL1A, TRG
18myelodysplastic syndromes10.0TRB, ABL1, TRA, FLT3
19peripheral t-cell lymphoma10.0TRG, TCL1A, TRB
20wilms tumor10.0MYB, ABL1, FLT3
21acute erythroid leukemia10.0TAL1, MYC, MYB
22squamous cell carcinoma of the head and neck10.0CDKN2A, MYC, ABL1
23type 1 diabetes mellitus10.0TRB, TRA, TRG
24myeloma10.0MYC, TCL1A, BCR, TRB
25cutaneous t cell lymphoma10.0MYB, TRB, TRG
26hodgkin's lymphoma10.0TRB, BCR, TCL1A, FLT3
27cervical cancer10.0MYB, CDKN2A, MYC
28follicular lymphoma10.0MYB, BCR, TCL1A, MYC
29glioblastoma multiforme10.0CDKN2A, MYC, ABL1, MYB
30leukemia, acute lymphoblastic 310.0BCR, FLT3, ABL1, CDKN2A, MYC
31retinoblastoma10.0MYC, BCR, ABL1, MYB, CDKN2A
32deficiency anemia10.0ABL1, FLT3, MYB
33acute lymphoblastic leukemia, childhood10.0FLT3, TLX1, ABL1, TRD, BCR, CDKN2A
34lymphoma, diffuse large cell10.0PICALM, MLLT10, MYC
35ipex syndrome10.0TRB, TRA, MYB, FLT3, BCR
36rheumatoid arthritis10.0MYB, TRD, TRA, TRG, TRB
37chronic lymphocytic leukemia10.0FLT3, MYB, ABL1, TCL1A, BCR, TRB
38lung cancer10.0MYB, FLT3, CDKN2A, TRB, MYC, BCR
39hematologic cancer9.9BCR, PICALM, ABL1, FLT3, MLLT10
40chronic myeloid leukemia9.9TRB, ABL1, FLT3, MYB, BCR, TAL1
41melanoma9.9MYB, MYC, ABL1, FLT3, CDKN2A, TRB
42non-hodgkin lymphoma9.9TAL1, BCR, TCL1A, MYC, MYB, TRB
43neurofibromatosis9.9
44langerhans-cell histiocytosis9.9
45autoimmune hemolytic anemia9.9
46acute t cell leukemia9.9
47pancytopenia9.9
48hemolytic anemia9.9
49histiocytosis9.9
50prostatitis9.9

Graphical network of the top 20 diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia:



Diseases related to precursor t-cell acute lymphoblastic leukemia

Symptoms for Precursor T-Cell Acute Lymphoblastic Leukemia

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Drugs & Therapeutics for Precursor T-Cell Acute Lymphoblastic Leukemia

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Precursor T-Cell Acute Lymphoblastic Leukemia

Drug clinical trials:

Search ClinicalTrials for Precursor T-Cell Acute Lymphoblastic Leukemia

Search NIH Clinical Center for Precursor T-Cell Acute Lymphoblastic Leukemia

Search CenterWatch for Precursor T-Cell Acute Lymphoblastic Leukemia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Precursor T-Cell Acute Lymphoblastic Leukemia

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Anatomical Context for Precursor T-Cell Acute Lymphoblastic Leukemia

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34MalaCards
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MalaCards organs/tissues related to Precursor T-Cell Acute Lymphoblastic Leukemia:

34
T cells, Bone marrow, Bone

Animal Models for Precursor T-Cell Acute Lymphoblastic Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Precursor T-Cell Acute Lymphoblastic Leukemia:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8TLX3, FLT3, MYC, CDKN2A, TRD, TRB
2MP:00053708.5ABL1, PICALM, MYB, MYC, BCR, CDKN2A
3MP:00028738.4TRG, TRB, BCR, MYC, MYB, ABL1
4MP:00053858.4ABL1, MYB, MYC, CNOT3, TAL1, TRD
5MP:00036318.2ABL1, TLX3, TLX1, MYC, STIL, BCR
6MP:00053808.1ABL1, PICALM, TLX1, MYB, MYC, STIL
7MP:00053818.1ABL1, TLX3, MYC, BCR, CDKN2A, TRD
8MP:00107717.8TLX3, MYB, MYC, TAL1, CDKN2A, TRD
9MP:00053787.7ABL1, PICALM, FLT3, MYB, MYC, STIL
10MP:00053767.7ABL1, PICALM, TLX3, FLT3, MYC, BCR
11MP:00107686.9MYB, FLT3, TLX3, PICALM, ABL1, MYC
12MP:00053976.9MYB, FLT3, TLX1, PICALM, ABL1, MYC
13MP:00053846.8MYB, FLT3, TLX1, PICALM, ABL1, MYC
14MP:00053876.5TRG, ABL1, PICALM, TLX3, TLX1, FLT3

Publications for Precursor T-Cell Acute Lymphoblastic Leukemia

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53PubMed
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Articles related to Precursor T-Cell Acute Lymphoblastic Leukemia:

idTitleAuthorsYear
1
Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report. (23057758)
2012
2
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
3
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. (14983942)
2004
4
ABL oncogene amplification with p16(INK4a) gene deletion in precursor T-cell acute lymphoblastic leukemia/lymphoma: report of the first case. (15282669)
2004

Variations for Precursor T-Cell Acute Lymphoblastic Leukemia

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Precursor T-Cell Acute Lymphoblastic Leukemia:

1
id Gene Name Type Significance SNP ID Assembly Location
1MYCNM_002467.4(MYC): c.214C> T (p.Pro72Ser)single nucleotide variantPathogenicrs28933407GRCh37Chr 8, 128750677: 128750677
2MYCNM_002467.4(MYC): c.302A> C (p.Asn101Thr)single nucleotide variantPathogenicrs121918683GRCh37Chr 8, 128750765: 128750765
3MYCNM_002467.4(MYC): c.162G> C (p.Glu54Asp)single nucleotide variantPathogenicrs121918684GRCh37Chr 8, 128750625: 128750625
4MYCNM_002467.4(MYC): c.220C> G (p.Pro74Ala)single nucleotide variantPathogenicrs121918685GRCh37Chr 8, 128750683: 128750683

Expression for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for Precursor T-Cell Acute Lymphoblastic Leukemia.

Pathways for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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51PathCards, 52PharmGKB, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome, 54QIAGEN, 5Cell Signaling Technology
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Pathways related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1ABL1, BCR
210.0TRB, TRA
39.9TRB, BCR, TRA
4
Show member pathways
DNA damage response39
9.8ABL1, MYC, CDKN2A
5
Show member pathways
9.8ABL1, MYC, CDKN2A
6
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.8CDKN2A, ABL1, MYC
7
Show member pathways
Cell cycle39
9.8CDKN2A, MYC, ABL1
89.8MYC, ABL1, CDKN2A
9
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.7TRA, MYC, TRB
109.7BCR, FLT3, ABL1
11
Show member pathways
9.6CDKN2A, ABL1, MYC, BCR
129.2CDKN2A, BCR, FLT3, ABL1, MYC
139.2TLX3, MYC, FLT3, TLX1

Compounds for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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52PharmGKB, 12DrugBank, 46Novoseek, 62Tocris Bioscience, 25HMDB
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Compounds related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate5210.4BCR, ABL1
2nilotinib52 1211.4ABL1, BCR
3bgl ii4610.4TRB, BCR
4homoharringtonine46 52 1212.4BCR, ABL1
5tachyplesin i4610.3MYC, CDKN2A
6busulfan46 52 1212.3ABL1, BCR, CDKN2A
7hind iii4610.2TRB, BCR
8bamhi4610.2BCR, TRB, TRA
9aclarubicin4610.1MYB, MYC
10ponatinib52 1211.1BCR, FLT3, ABL1
11camptothecin46 62 1212.0CDKN2A, MYC, ABL1
12hmba4610.0CDKN2A, MYC
13phosphorothioate469.9MYC, MYB
14daunorubicin46 52 1211.9CDKN2A, MYC, FLT3
15nitroblue tetrazolium469.9MYC, MYB
16phorbol469.8MYB, MYC, TRB
17ecori469.8TRB, MYB
18agarose469.8CDKN2A, MYC, FLT3
19dmso469.8BCR, MYC, MYB, ABL1
20herbimycin a46 6210.8ABL1, FLT3, MYC
21af 10469.7PICALM, MLLT10, TLX1
22cytarabine46 52 1211.6ABL1, FLT3, MYC, BCR, CDKN2A
235-aza-2deoxycytidine469.6FLT3, MYC, CDKN2A
24doxorubicin46 52 1211.5CDKN2A, MYC, MYB, FLT3
25imatinib46 52 1211.4BCR, MYC, MYB, FLT3, ABL1
26thymidine46 2510.4FLT3, MYB, MYC, BCR
27arsenite46 2510.3CDKN2A, MYC, FLT3
28vegf469.2ABL1, FLT3, MYB, MYC, TAL1, CDKN2A
29retinoic acid46 2510.1ABL1, FLT3, MYB, MYC, TAL1, CDKN2A
30serine469.0ABL1, MYB, MYC, TCL1A, BCR, TAL1
31tyrosine469.0ABL1, TLX1, FLT3, MYB, MYC, BCR
32leucine468.8PICALM, MLLT10, MYB, MYC, BCR, CDKN2A
33oligonucleotide468.6TRB, ABL1, TLX1, FLT3, MYB, MYC
34threonine468.6ABL1, TLX1, FLT3, MYB, MYC, TCL1A

GO Terms for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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17Gene Ontology
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Cellular components related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.8CDKN2A, ABL1, PICALM, MLLT10, TLX3, TLX1

Biological processes related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:04800810.1BCR, ABL1
2regulation of stem cell maintenanceGO:200003610.0TAL1, CNOT3
3peptidyl-tyrosine phosphorylationGO:0181089.6ABL1, FLT3, BCR
4regulation of endocytosisGO:0301009.5PICALM, ABL1
5hemopoiesisGO:0300979.4PICALM, FLT3, TAL1
6positive regulation of transcription, DNA-templatedGO:0458939.0CDKN2A, TAL1, MYC, MYB, PICALM
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CDKN2A, DDX3X, MLLT10, TLX1, MYB, MYC

Molecular functions related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1E-box bindingGO:0708889.9TAL1, MYC
2sequence-specific DNA binding transcription factor activityGO:0037008.4MLLT10, TLX3, TLX1, MYB, MYC, TAL1
3DNA bindingGO:0036778.0DDX3X, ABL1, MLLT10, MYB, MYC, CDKN2A
4protein bindingGO:0055155.3CDKN2A, DDX3X, ABL1, PICALM, MLLT10, TLX3

Products for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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  • Antibodies
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Sources for Precursor T-Cell Acute Lymphoblastic Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet