MCID: PRC049
MIFTS: 38

Precursor T-Cell Acute Lymphoblastic Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases, Rare diseases

Aliases & Classifications for Precursor T-Cell Acute Lymphoblastic Leukemia

MalaCards integrated aliases for Precursor T-Cell Acute Lymphoblastic Leukemia:

Name: Precursor T-Cell Acute Lymphoblastic Leukemia 55
T-All 55 51
Precursor T-Cell Acute Lymphoblastic Leukemia/lymphoma 55
Precursor T-Cell Acute Lymphocytic Leukemia/lymphoma 55
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 69
Precursor T-Cell Acute Lymphocytic Leukemia 55
Adult T-Cell Lymphoma/leukemia 69

Classifications:



External Ids:

Orphanet 55 ORPHA99861
UMLS via Orphanet 70 C1961099
ICD10 via Orphanet 33 C91.0
UMLS 69 C1961099

Summaries for Precursor T-Cell Acute Lymphoblastic Leukemia

MalaCards based summary : Precursor T-Cell Acute Lymphoblastic Leukemia, also known as t-all, is related to lymphoblastic leukemia and leukemia. An important gene associated with Precursor T-Cell Acute Lymphoblastic Leukemia is BAX (BCL2 Associated X, Apoptosis Regulator), and among its related pathways/superpathways are Pathways in cancer and HTLV-I infection. Affiliated tissues include t cells, bone marrow and bone, and related phenotypes are cellular and embryo

Related Diseases for Precursor T-Cell Acute Lymphoblastic Leukemia

Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 lymphoblastic leukemia 31.3 ABL1 BAX BCR CDKN2A FLT3 PICALM
2 leukemia 31.2 ABL1 BAX BCR CDKN2A FLT3 TAL1
3 lymphoma 31.0 BAX BCL10 MYC TCL1A
4 myeloid leukemia 30.6 ABL1 BCR FLT3 MYC PICALM
5 leukemia, acute myeloid 30.3 ABL1 BCR CDKN2A FLT3 MLLT10 MYB
6 acute t cell leukemia 10.6 BAX BCL10 TRB
7 suppressor of tumorigenicity 3 10.6 BAX CDKN2A MYC
8 neonatal leukemia 10.6 FLT3 MLLT10 MYC
9 philadelphia-negative chronic myeloid leukemia 10.5 ABL1 BCR
10 acute lymphocytic leukemia 10.5 BCR CDKN2A TAL1 TLX3
11 leukemia, acute lymphoblastic 3 10.5 ABL1 BCR CDKN2A FLT3
12 b-cell lymphomas 10.5 BAX BCL10 CDKN2A MYC TCL1A
13 t-cell prolymphocytic leukemia 10.5 ABL1 MYC TCL1A
14 t-cell leukemia 10.5 TAL1 TCL1A TLX1 TLX3
15 lymphoma, non-hodgkin, familial 10.4 BAX BCL10 BCR MYC TCL1A
16 hematologic cancer 10.4 ABL1 BCR FLT3 MLLT10 PICALM
17 bone marrow cancer 10.4 ABL1 BCR FLT3
18 burkitt lymphoma 10.4 BAX BCR MYC
19 leukemia, chronic myeloid 10.4 ABL1 BCR FLT3 MYB MYC
20 leukemia, acute lymphoblastic 10.3 ABL1 BAX BCL10 BCR CDKN2A FLT3
21 thyroid lymphoma 10.2 CDKN2A PICALM
22 leukemia, chronic lymphocytic 10.2 BAX BCL10 BCR TCL1A
23 lymphoblastic lymphoma 10.1
24 laryngitis 10.1
25 pancreatitis 10.0
26 bone marrow necrosis 10.0
27 retinal detachment 10.0
28 thymoma, familial 10.0
29 aging 10.0
30 acute biphenotypic leukemia 10.0
31 acute pancreatitis 10.0
32 thymoma 10.0
33 retinitis 10.0

Graphical network of the top 20 diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia:



Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia

Symptoms & Phenotypes for Precursor T-Cell Acute Lymphoblastic Leukemia

MGI Mouse Phenotypes related to Precursor T-Cell Acute Lymphoblastic Leukemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 ABL1 BAX BCL10 BCR CDKN2A DDX3X
2 embryo MP:0005380 10.02 DDX3X MYB MYC PICALM STIL TAL1
3 hematopoietic system MP:0005397 10 TAL1 TLX1 ABL1 BAX BCL10 BCR
4 immune system MP:0005387 9.93 ABL1 BAX BCL10 BCR CDKN2A FLT3
5 mortality/aging MP:0010768 9.77 TLX3 STIL TAL1 ABL1 BAX BCL10
6 nervous system MP:0003631 9.36 ABL1 BAX BCL10 BCR CDKN2A DDX3X

Drugs & Therapeutics for Precursor T-Cell Acute Lymphoblastic Leukemia

Search Clinical Trials , NIH Clinical Center for Precursor T-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Precursor T-Cell Acute Lymphoblastic Leukemia

Anatomical Context for Precursor T-Cell Acute Lymphoblastic Leukemia

MalaCards organs/tissues related to Precursor T-Cell Acute Lymphoblastic Leukemia:

38
T Cells, Bone Marrow, Bone, Appendix, Cervix, Myeloid

Publications for Precursor T-Cell Acute Lymphoblastic Leukemia

Articles related to Precursor T-Cell Acute Lymphoblastic Leukemia:

(show all 17)
# Title Authors Year
1
A 25-Year-Old Man with Exudative Retinal Detachments and Infiltrates without Hematological or Neurological Findings Found to Have Relapsed Precursor T-Cell Acute Lymphoblastic Leukemia. ( 26483676 )
2015
2
Secondary pancreatic involvement by precursor T-cell acute lymphoblastic leukemia presenting as acute pancreatitis. ( 26905170 )
2015
3
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. ( 25624896 )
2015
4
NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia. ( 23349303 )
2013
5
Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report. ( 23057758 )
2012
6
Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder. ( 22184539 )
2011
7
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. ( 18722237 )
2008
8
Gum hypertrophy - an unusual presenting feature in a case of precursor T-cell acute lymphoblastic leukemia. ( 27264925 )
2008
9
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. ( 17369128 )
2007
10
A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia. ( 17498558 )
2007
11
Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. ( 16493618 )
2006
12
An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma. ( 15843931 )
2005
13
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. ( 14983942 )
2004
14
ABL oncogene amplification with p16(INK4a) gene deletion in precursor T-cell acute lymphoblastic leukemia/lymphoma: report of the first case. ( 15282669 )
2004
15
Precursor T-cell acute lymphoblastic leukemia in adults: age-related immunophenotypic, cytogenetic, and molecular subsets. ( 11863221 )
2002
16
Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix. ( 12004362 )
2002
17
Orbital mass secondary to precursor T-cell acute lymphoblastic leukemia: a rare presentation. ( 11231781 )
2001

Variations for Precursor T-Cell Acute Lymphoblastic Leukemia

ClinVar genetic disease variations for Precursor T-Cell Acute Lymphoblastic Leukemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BAX NM_138761.3(BAX): c.199G> A (p.Gly67Arg) single nucleotide variant Pathogenic rs398122513 GRCh37 Chromosome 19, 49459056: 49459056
2 BAX NM_138761.3(BAX): c.115_121delGGGGGGG (p.Gly39Argfs) deletion Pathogenic rs398122842 GRCh37 Chromosome 19, 49458972: 49458978
3 BCL10 NM_003921.4(BCL10): c.136_137insA (p.Ile46Asnfs) insertion Pathogenic rs387906351 GRCh37 Chromosome 1, 85736511: 85736511

Expression for Precursor T-Cell Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for Precursor T-Cell Acute Lymphoblastic Leukemia.

Pathways for Precursor T-Cell Acute Lymphoblastic Leukemia

Pathways related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.57 ABL1 BAX BCR CDKN2A FLT3 MYC
2 12.14 BAX CDKN2A MYB MYC
3
Show member pathways
12.07 ABL1 BAX CDKN2A MYC
4 11.82 BAX FLT3 MYC TLX1 TLX3
5 11.68 ABL1 BAX CDKN2A MYC
6
Show member pathways
11.54 ABL1 BAX BCR CDKN2A MYC
7 10.78 ABL1 CDKN2A MYC
8
Show member pathways
10.27 ABL1 BAX CDKN2A MYC

GO Terms for Precursor T-Cell Acute Lymphoblastic Leukemia

Cellular components related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.83 ABL1 BAX BCL10 CDKN2A DDX3X FLT3
2 protein complex GO:0043234 9.23 ABL1 BCL10 BCR FLT3 MLLT10 MYC

Biological processes related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 CDKN2A DDX3X MLLT10 MYB MYC TAL1
2 regulation of hematopoietic stem cell differentiation GO:1902036 9.72 ABL1 MYB TAL1
3 positive regulation of apoptotic process GO:0043065 9.72 ABL1 BAX BCL10 CDKN2A DDX3X
4 neural tube closure GO:0001843 9.67 ABL1 BCL10 STIL
5 hemopoiesis GO:0030097 9.65 FLT3 PICALM TAL1
6 positive regulation of transcription, DNA-templated GO:0045893 9.63 BCL10 CDKN2A MYB MYC PICALM TAL1
7 definitive hemopoiesis GO:0060216 9.56 BCR TAL1
8 positive regulation of protein oligomerization GO:0032461 9.54 BAX TCL1A
9 hypothalamus development GO:0021854 9.52 BAX MYC
10 positive regulation of glial cell proliferation GO:0060252 9.51 MYB MYC
11 positive regulation of mitochondrial membrane potential GO:0010918 9.46 MYC TCL1A
12 negative regulation of ubiquitin-protein transferase activity GO:0051444 9.43 ABL1 CDKN2A
13 B cell apoptotic process GO:0001783 9.37 BAX BCL10
14 leukocyte homeostasis GO:0001776 9.26 BAX FLT3
15 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.13 BCL10 DDX3X MYC
16 positive regulation of neuron death GO:1901216 8.8 ABL1 MYB PICALM
17 regulation of transcription, DNA-templated GO:0006355 10.22 ABL1 CDKN2A DDX3X MLLT10 MYB MYC

Molecular functions related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ABL1 BAX BCL10 BCR CDKN2A DDX3X
2 transcription factor binding GO:0008134 9.46 BCL10 CDKN2A DDX3X MYC
3 DNA binding GO:0003677 9.28 ABL1 CDKN2A DDX3X MLLT10 MYB MYC

Sources for Precursor T-Cell Acute Lymphoblastic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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