MCID: PRC049
MIFTS: 40

Precursor T-Cell Acute Lymphoblastic Leukemia malady

Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories

Aliases & Classifications for Precursor T-Cell Acute Lymphoblastic Leukemia

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Sources:
47Orphanet, 60UMLS, 26ICD10 via Orphanet
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Precursor T-Cell Acute Lymphoblastic Leukemia, Aliases & Descriptions:

Name: Precursor T-Cell Acute Lymphoblastic Leukemia 47
Precursor T-Cell Acute Lymphoblastic Leukemia/lymphoma 47
Precursor T-Cell Acute Lymphocytic Leukemia/lymphoma 47
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 60
 
Precursor T-Cell Acute Lymphocytic Leukemia 47
Adult T-Cell Lymphoma/leukemia 60
T-All 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


External Ids:

Orphanet47 99861
ICD10 via Orphanet26 C91.0

Summaries for Precursor T-Cell Acute Lymphoblastic Leukemia

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MalaCards based summary: Precursor T-Cell Acute Lymphoblastic Leukemia, also known as precursor t-cell acute lymphoblastic leukemia/lymphoma, is related to lymphoblastic leukemia and lymphoblastic lymphoma. An important gene associated with Precursor T-Cell Acute Lymphoblastic Leukemia is TLX1 (T-cell leukemia homeobox 1), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and Cytokines and Inflammatory Response. The compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and bone, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Related Diseases for Precursor T-Cell Acute Lymphoblastic Leukemia

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Diseases in the Precursor B-Cell Acute Lymphoblastic Leukemia family:

precursor t-cell acute lymphoblastic leukemia

Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoblastic leukemia32.3TLX1
2lymphoblastic lymphoma31.3TAL1, TRB
3prolymphocytic leukemia30.3MYC, TCL1A
4t-cell leukemia30.0MYB, TAL1, TCL1A, MYC, TLX1
5hodgkin lymphoma30.0TRB, BCR, TCL1A, FLT3
6myeloid leukemia29.7FLT3, PICALM, TRB, BCR, ABL1, MLLT10
7acute leukemia29.2ABL1, TRB, FLT3, TRD, TAL1, BCR
8leukemia28.8MYB, FLT3, TLX1, TLX3, MLLT10, PICALM
9laryngitis10.6
10acute biphenotypic leukemia10.4
11thymoma10.4
12bone marrow necrosis10.4
13bone marrow cancer10.3FLT3, ABL1
14primary effusion lymphoma10.3TCL1A, MYC
15thyroid lymphoma10.3PICALM
16neuroectodermal tumor10.3MYC, MYB
17chronic myelomonocytic leukemia10.3FLT3, BCR
18gastrointestinal stromal tumor10.3ABL1, BCR, FLT3
19burkitt lymphoma10.2TCL1A, TRG
20myelodysplastic syndrome10.2TRB, ABL1, TRA, FLT3
21peripheral t-cell lymphoma10.2TRG, TCL1A, TRB
22wilms tumor10.1MYB, ABL1, FLT3
23acute erythroid leukemia10.1TAL1, MYC, MYB
24squamous cell carcinoma, head and neck10.1CDKN2A, MYC, ABL1
25diabetes mellitus, insulin-dependent10.1TRB, TRA, TRG
26myeloma10.1MYC, TCL1A, BCR, TRB
27cutaneous t cell lymphoma10.1MYB, TRB, TRG
28chromosomal triplication10.1BCR, TRB, FLT3, MYC
29cervical cancer, somatic10.1MYB, CDKN2A, MYC
30follicular lymphoma10.1MYB, BCR, TCL1A, MYC
31glioblastoma10.1CDKN2A, MYC, ABL1, MYB
32precursor b-cell acute lymphoblastic leukemia10.0BCR, FLT3, ABL1, CDKN2A, MYC
33retinoblastoma10.0MYC, BCR, ABL1, MYB, CDKN2A
34deficiency anemia10.0ABL1, FLT3, MYB
35acute lymphoblastic leukemia, childhood10.0FLT3, TLX1, ABL1, TRD, BCR, CDKN2A
36ipex syndrome10.0TRB, TRA, MYB, FLT3, BCR
37rheumatoid arthritis9.9MYB, TRD, TRA, TRG, TRB
38ataxia-telangiectasia9.9
39hemolytic anemia9.9
40sinusitis9.9
41langerhans-cell histiocytosis9.9
42neurofibromatosis9.9
43cleft lip9.9
44autoimmune hemolytic anemia9.9
45acute t cell leukemia9.9
46pancytopenia9.9
47histiocytosis9.9
48prostatitis9.9
49sarcoma9.9
50ataxia9.9

Graphical network of the top 20 diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia:



Diseases related to precursor t-cell acute lymphoblastic leukemia

Symptoms for Precursor T-Cell Acute Lymphoblastic Leukemia

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Drugs & Therapeutics for Precursor T-Cell Acute Lymphoblastic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Precursor T-Cell Acute Lymphoblastic Leukemia

Search NIH Clinical Center for Precursor T-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Precursor T-Cell Acute Lymphoblastic Leukemia

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Anatomical Context for Precursor T-Cell Acute Lymphoblastic Leukemia

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MalaCards organs/tissues related to Precursor T-Cell Acute Lymphoblastic Leukemia:

31
T cells, Bone marrow, Bone, Cervix, Myeloid, Appendix

Animal Models for Precursor T-Cell Acute Lymphoblastic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Precursor T-Cell Acute Lymphoblastic Leukemia:

35 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8TLX3, FLT3, MYC, CDKN2A, TRD, TRB
2MP:00053708.5ABL1, PICALM, MYB, MYC, BCR, CDKN2A
3MP:00028738.4TRG, TRB, BCR, MYC, MYB, ABL1
4MP:00053858.4ABL1, MYB, MYC, CNOT3, TAL1, TRD
5MP:00036318.2ABL1, TLX3, TLX1, MYC, STIL, BCR
6MP:00053808.1ABL1, PICALM, TLX1, MYB, MYC, STIL
7MP:00053818.1ABL1, TLX3, MYC, BCR, CDKN2A, TRD
8MP:00107717.8TLX3, MYB, MYC, TAL1, CDKN2A, TRD
9MP:00053787.7ABL1, PICALM, FLT3, MYB, MYC, STIL
10MP:00053767.7ABL1, PICALM, TLX3, FLT3, MYC, BCR
11MP:00107686.9MYB, FLT3, TLX3, PICALM, ABL1, MYC
12MP:00053976.9MYB, FLT3, TLX1, PICALM, ABL1, MYC
13MP:00053846.8MYB, FLT3, TLX1, PICALM, ABL1, MYC
14MP:00053876.5TRG, ABL1, PICALM, TLX3, TLX1, FLT3

Publications for Precursor T-Cell Acute Lymphoblastic Leukemia

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Articles related to Precursor T-Cell Acute Lymphoblastic Leukemia:

(show all 14)
idTitleAuthorsYear
1
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. (25624896)
2015
2
NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia. (23349303)
2013
3
Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report. (23057758)
2012
4
Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder. (22184539)
2011
5
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. (18722237)
2008
6
A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia. (17498558)
2007
7
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
8
Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. (16493618)
2006
9
An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma. (15843931)
2005
10
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. (14983942)
2004
11
ABL oncogene amplification with p16(INK4a) gene deletion in precursor T-cell acute lymphoblastic leukemia/lymphoma: report of the first case. (15282669)
2004
12
Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix. (12004362)
2002
13
Precursor T-cell acute lymphoblastic leukemia in adults: age-related immunophenotypic, cytogenetic, and molecular subsets. (11863221)
2002
14
Orbital mass secondary to precursor T-cell acute lymphoblastic leukemia: a rare presentation. (11231781)
2001

Variations for Precursor T-Cell Acute Lymphoblastic Leukemia

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Expression for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Search GEO for disease gene expression data for Precursor T-Cell Acute Lymphoblastic Leukemia.

Pathways for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Pathways related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1BCR, ABL1
210.0TRA, TRB
39.9TRA, TRB, BCR
4
Show member pathways
DNA damage response36
9.8CDKN2A, MYC, ABL1
5
Show member pathways
9.8CDKN2A, MYC, ABL1
6
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.8CDKN2A, MYC, ABL1
79.8CDKN2A, MYC, ABL1
8
Show member pathways
Cell cycle36
9.8ABL1, MYC, CDKN2A
9
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
9.7TRA, TRB, MYC
109.7ABL1, FLT3, BCR
11
Show member pathways
9.6ABL1, MYC, BCR, CDKN2A
129.2ABL1, FLT3, MYC, BCR, CDKN2A
139.2TLX3, TLX1, FLT3, MYC

Compounds for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Compounds related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 34)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate4910.4BCR, ABL1
2nilotinib49 1211.4ABL1, BCR
3bgl ii4310.4TRB, BCR
4homoharringtonine43 49 1212.4BCR, ABL1
5tachyplesin i4310.3MYC, CDKN2A
6busulfan43 49 1212.3ABL1, BCR, CDKN2A
7hind iii4310.2TRB, BCR
8bamhi4310.2BCR, TRB, TRA
9aclarubicin4310.1MYB, MYC
10ponatinib49 1211.1BCR, FLT3, ABL1
11camptothecin43 59 1212.0CDKN2A, MYC, ABL1
12hmba4310.0CDKN2A, MYC
13phosphorothioate439.9MYC, MYB
14daunorubicin43 49 1211.9CDKN2A, MYC, FLT3
15nitroblue tetrazolium439.9MYC, MYB
16phorbol439.8MYB, MYC, TRB
17ecori439.8TRB, MYB
18agarose439.8CDKN2A, MYC, FLT3
19dmso439.8BCR, MYC, MYB, ABL1
20herbimycin a43 5910.8ABL1, FLT3, MYC
21af 10439.7PICALM, MLLT10, TLX1
22cytarabine43 49 1211.6ABL1, FLT3, MYC, BCR, CDKN2A
235-aza-2deoxycytidine439.6FLT3, MYC, CDKN2A
24doxorubicin43 49 1211.5CDKN2A, MYC, MYB, FLT3
25imatinib43 49 1211.4BCR, MYC, MYB, FLT3, ABL1
26thymidine43 2410.4FLT3, MYB, MYC, BCR
27arsenite43 2410.3CDKN2A, MYC, FLT3
28vegf439.2ABL1, FLT3, MYB, MYC, TAL1, CDKN2A
29retinoic acid43 2410.1ABL1, FLT3, MYB, MYC, TAL1, CDKN2A
30serine439.0ABL1, MYB, MYC, TCL1A, BCR, TAL1
31tyrosine439.0ABL1, TLX1, FLT3, MYB, MYC, BCR
32leucine438.8PICALM, MLLT10, MYB, MYC, BCR, CDKN2A
33oligonucleotide438.6TRB, ABL1, TLX1, FLT3, MYB, MYC
34threonine438.6ABL1, TLX1, FLT3, MYB, MYC, TCL1A

GO Terms for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Cellular components related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056346.8CDKN2A, ABL1, PICALM, MLLT10, TLX3, TLX1

Biological processes related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:004800810.1BCR, ABL1
2regulation of stem cell maintenanceGO:0200003610.0TAL1, CNOT3
3peptidyl-tyrosine phosphorylationGO:00181089.6ABL1, FLT3, BCR
4regulation of endocytosisGO:00301009.5PICALM, ABL1
5hemopoiesisGO:00300979.4PICALM, FLT3, TAL1
6positive regulation of transcription, DNA-templatedGO:00458939.0CDKN2A, TAL1, MYC, MYB, PICALM
7positive regulation of transcription from RNA polymerase II promoterGO:00459448.3CDKN2A, DDX3X, MLLT10, TLX1, MYB, MYC

Molecular functions related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1E-box bindingGO:00708889.9TAL1, MYC
2sequence-specific DNA binding transcription factor activityGO:00037008.4MLLT10, TLX3, TLX1, MYB, MYC, TAL1
3DNA bindingGO:00036778.0DDX3X, ABL1, MLLT10, MYB, MYC, CDKN2A
4protein bindingGO:00055155.3CDKN2A, DDX3X, ABL1, PICALM, MLLT10, TLX3

Products for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Sources for Precursor T-Cell Acute Lymphoblastic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet