T-ALL
MCID: PRC049
MIFTS: 46

Precursor T-Cell Acute Lymphoblastic Leukemia (T-ALL) malady

Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories
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Summaries for Precursor T-Cell Acute Lymphoblastic Leukemia

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MalaCards based summary: Precursor T-Cell Acute Lymphoblastic Leukemia, also known as T-ALL, is related to lymphoblastic leukemia and lymphoblastic lymphoma. An important gene associated with Precursor T-Cell Acute Lymphoblastic Leukemia is TLX1 (T-cell leukemia homeobox 1), and among its related pathways are Gefitinib Pathway, Pharmacokinetics and Cytokines and Inflammatory Response. The compounds bosutinib monohydrate and nilotinib have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and bone, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Precursor T-Cell Acute Lymphoblastic Leukemia

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Sources:
48Orphanet, 62UMLS, 26ICD10 via Orphanet
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Precursor T-Cell Acute Lymphoblastic Leukemia, Aliases & Descriptions:

Name: Precursor T-Cell Acute Lymphoblastic Leukemia 48
T-All 48 62
Precursor T-Cell Acute Lymphoblastic Leukemia/lymphoma 48
Precursor T Cell Acute Lymphoblastic Leukemia Lymphoma 62
 
Precursor T-Cell Acute Lymphocytic Leukemia/lymphoma 48
Precursor T Cell Acute Lymphoblastic Leukemia 62
Precursor T-Cell Acute Lymphocytic Leukemia 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


External Ids:

ICD10 via Orphanet26 C91.0

Related Diseases for Precursor T-Cell Acute Lymphoblastic Leukemia

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Diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoblastic leukemia32.3TLX1
2lymphoblastic lymphoma31.3TRB, TAL1
3prolymphocytic leukemia30.4TCL1A, MYC
4t-cell leukemia30.1TLX1, MYB, MYC, TCL1A, TAL1
5acute lymphoblastic leukemia30.0TRG, ABL1, PICALM, MLLT10, FLT3, MYB
6myeloid leukemia29.7ABL1, PICALM, MLLT10, FLT3, MYB, MYC
7non-hodgkin lymphoma29.5FLT3, MYB, MYC, TCL1A, BCR, TAL1
8acute leukemia29.3ABL1, MLLT10, FLT3, MYB, STIL, BCR
9leukemia28.8TRG, ABL1, PICALM, MLLT10, TLX3, TLX1
10acute biphenotypic leukemia10.4
11acute myeloid leukemia10.4
12laryngitis10.4
13thymoma10.4
14bone marrow cancer10.3ABL1, FLT3
15lymphoma aidsrelated10.3MYC, TCL1A
16thyroid lymphoma10.3PICALM
17neuroectodermal tumor10.3MYC, MYB
18pdgfrb-associated chronic eosinophilic leukemia10.3BCR, FLT3
19gastrointestinal stromal tumor10.3ABL1, FLT3, BCR
20burkitt's lymphoma10.2TRG, TCL1A
21myelodysplastic syndromes10.2ABL1, FLT3, TRB, TRA
22peripheral t-cell lymphoma10.2TCL1A, TRB, TRG
23wilms tumor10.2MYB, FLT3, ABL1
24acute erythroid leukemia10.1TAL1, MYC, MYB
25squamous cell carcinoma of the head and neck10.1CDKN2A, MYC, ABL1
26type 1 diabetes mellitus10.1TRB, TRA, TRG
27myeloma10.1MYC, TCL1A, BCR, TRB
28cutaneous t cell lymphoma10.1MYB, TRB, TRG
29hodgkin's lymphoma10.1TRB, BCR, TCL1A, FLT3
30cervical cancer10.1MYB, MYC, CDKN2A
31follicular lymphoma10.1MYB, MYC, TCL1A, BCR
32glioblastoma10.1ABL1, MYB, MYC, CDKN2A
33leukemia, acute lymphoblastic 310.1ABL1, FLT3, MYC, BCR, CDKN2A
34retinoblastoma10.0ABL1, MYB, MYC, BCR, CDKN2A
35deficiency anemia10.0MYB, FLT3, ABL1
36acute lymphoblastic leukemia, childhood10.0ABL1, TLX1, FLT3, BCR, CDKN2A, TRD
37ipex syndrome10.0FLT3, MYB, BCR, TRB, TRA
38ataxia telangiectasia9.9
39hemolytic anemia9.9
40sinusitis9.9
41langerhans-cell histiocytosis9.9
42autoimmune hemolytic anemia9.9
43acute t cell leukemia9.9
44cleft lip9.9
45neurofibromatosis9.9
46pancytopenia9.9
47histiocytosis9.9
48prostatitis9.9
49sarcoma9.9
50ataxia9.9

Graphical network of the top 20 diseases related to Precursor T-Cell Acute Lymphoblastic Leukemia:



Diseases related to precursor t-cell acute lymphoblastic leukemia

Symptoms for Precursor T-Cell Acute Lymphoblastic Leukemia

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Drugs & Therapeutics for Precursor T-Cell Acute Lymphoblastic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Precursor T-Cell Acute Lymphoblastic Leukemia

Search NIH Clinical Center for Precursor T-Cell Acute Lymphoblastic Leukemia

Genetic Tests for Precursor T-Cell Acute Lymphoblastic Leukemia

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Anatomical Context for Precursor T-Cell Acute Lymphoblastic Leukemia

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MalaCards organs/tissues related to Precursor T-Cell Acute Lymphoblastic Leukemia:

32
T cells, Bone marrow, Bone, Cervix, Myeloid, Appendix

Animal Models for Precursor T-Cell Acute Lymphoblastic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Precursor T-Cell Acute Lymphoblastic Leukemia:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8TLX3, FLT3, MYC, CDKN2A, TRD, TRB
2MP:00053708.5ABL1, PICALM, MYB, MYC, BCR, CDKN2A
3MP:00028738.4TRG, TRB, BCR, MYC, MYB, ABL1
4MP:00053858.4ABL1, MYB, MYC, CNOT3, TAL1, TRD
5MP:00036318.2ABL1, TLX3, TLX1, MYC, STIL, BCR
6MP:00053808.1ABL1, PICALM, TLX1, MYB, MYC, STIL
7MP:00053818.1ABL1, TLX3, MYC, BCR, CDKN2A, TRD
8MP:00107717.8TLX3, MYB, MYC, TAL1, CDKN2A, TRD
9MP:00053787.7ABL1, PICALM, FLT3, MYB, MYC, STIL
10MP:00053767.7ABL1, PICALM, TLX3, FLT3, MYC, BCR
11MP:00107686.9MYB, FLT3, TLX3, PICALM, ABL1, MYC
12MP:00053976.9MYB, FLT3, TLX1, PICALM, ABL1, MYC
13MP:00053846.8MYB, FLT3, TLX1, PICALM, ABL1, MYC
14MP:00053876.5TRG, ABL1, PICALM, TLX3, TLX1, FLT3

Publications for Precursor T-Cell Acute Lymphoblastic Leukemia

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Articles related to Precursor T-Cell Acute Lymphoblastic Leukemia:

(show all 12)
idTitleAuthorsYear
1
NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia. (23349303)
2013
2
Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder. (22184539)
2011
3
Primary laryngeal manifestation in precursor T-cell acute lymphoblastic leukemia. (18722237)
2008
4
A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia. (17498558)
2007
5
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
6
Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. (16493618)
2006
7
An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma. (15843931)
2005
8
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. (14983942)
2004
9
ABL oncogene amplification with p16(INK4a) gene deletion in precursor T-cell acute lymphoblastic leukemia/lymphoma: report of the first case. (15282669)
2004
10
Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix. (12004362)
2002
11
Precursor T-cell acute lymphoblastic leukemia in adults: age-related immunophenotypic, cytogenetic, and molecular subsets. (11863221)
2002
12
Orbital mass secondary to precursor T-cell acute lymphoblastic leukemia: a rare presentation. (11231781)
2001

Variations for Precursor T-Cell Acute Lymphoblastic Leukemia

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Expression for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Expression patterns in normal tissues for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for Precursor T-Cell Acute Lymphoblastic Leukemia.

Pathways for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Pathways related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1BCR, ABL1
210.0TRA, TRB
39.9TRA, TRB, BCR
4
Show member pathways
DNA damage response37
9.8CDKN2A, MYC, ABL1
5
Show member pathways
9.8CDKN2A, MYC, ABL1
6
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.8CDKN2A, MYC, ABL1
79.8CDKN2A, MYC, ABL1
8
Show member pathways
Cell cycle37
9.8ABL1, MYC, CDKN2A
9
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.7TRA, TRB, MYC
109.7ABL1, FLT3, BCR
11
Show member pathways
9.6ABL1, MYC, BCR, CDKN2A
129.2ABL1, FLT3, MYC, BCR, CDKN2A
139.2TLX3, TLX1, FLT3, MYC

Compounds for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Compounds related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1bosutinib monohydrate5010.4BCR, ABL1
2nilotinib50 1111.4ABL1, BCR
3bgl ii4410.4TRB, BCR
4homoharringtonine44 50 1112.4BCR, ABL1
5tachyplesin i4410.3MYC, CDKN2A
6busulfan44 50 1112.3ABL1, BCR, CDKN2A
7hind iii4410.2TRB, BCR
8bamhi4410.2BCR, TRB, TRA
9aclarubicin4410.1MYB, MYC
10ponatinib50 1111.1BCR, FLT3, ABL1
11camptothecin44 61 1112.0CDKN2A, MYC, ABL1
12hmba4410.0CDKN2A, MYC
13phosphorothioate449.9MYC, MYB
14daunorubicin44 50 1111.9CDKN2A, MYC, FLT3
15nitroblue tetrazolium449.9MYC, MYB
16phorbol449.8MYB, MYC, TRB
17ecori449.8TRB, MYB
18agarose449.8CDKN2A, MYC, FLT3
19dmso449.8BCR, MYC, MYB, ABL1
20herbimycin a44 6110.8ABL1, FLT3, MYC
21af 10449.7PICALM, MLLT10, TLX1
22cytarabine44 50 1111.6ABL1, FLT3, MYC, BCR, CDKN2A
235-aza-2deoxycytidine449.6FLT3, MYC, CDKN2A
24doxorubicin44 50 1111.5CDKN2A, MYC, MYB, FLT3
25imatinib44 50 1111.4BCR, MYC, MYB, FLT3, ABL1
26thymidine44 2410.4FLT3, MYB, MYC, BCR
27arsenite44 2410.3CDKN2A, MYC, FLT3
28vegf449.2ABL1, FLT3, MYB, MYC, TAL1, CDKN2A
29retinoic acid44 2410.1ABL1, FLT3, MYB, MYC, TAL1, CDKN2A
30serine449.0ABL1, MYB, MYC, TCL1A, BCR, TAL1
31tyrosine449.0ABL1, TLX1, FLT3, MYB, MYC, BCR
32leucine448.8PICALM, MLLT10, MYB, MYC, BCR, CDKN2A
33oligonucleotide448.6TRB, ABL1, TLX1, FLT3, MYB, MYC
34threonine448.6ABL1, TLX1, FLT3, MYB, MYC, TCL1A

GO Terms for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Cellular components related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056346.8CDKN2A, ABL1, PICALM, MLLT10, TLX3, TLX1

Biological processes related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor receptor signaling pathwayGO:04800810.1BCR, ABL1
2regulation of stem cell maintenanceGO:200003610.0TAL1, CNOT3
3peptidyl-tyrosine phosphorylationGO:0181089.6ABL1, FLT3, BCR
4regulation of endocytosisGO:0301009.5PICALM, ABL1
5hemopoiesisGO:0300979.4PICALM, FLT3, TAL1
6positive regulation of transcription, DNA-templatedGO:0458939.0CDKN2A, TAL1, MYC, MYB, PICALM
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.3CDKN2A, DDX3X, MLLT10, TLX1, MYB, MYC

Molecular functions related to Precursor T-Cell Acute Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1E-box bindingGO:0708889.9TAL1, MYC
2sequence-specific DNA binding transcription factor activityGO:0037008.4MLLT10, TLX3, TLX1, MYB, MYC, TAL1
3DNA bindingGO:0036778.0DDX3X, ABL1, MLLT10, MYB, MYC, CDKN2A
4protein bindingGO:0055155.3CDKN2A, DDX3X, ABL1, PICALM, MLLT10, TLX3

Products for genes affiliated with Precursor T-Cell Acute Lymphoblastic Leukemia

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Sources for Precursor T-Cell Acute Lymphoblastic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet