MCID: PRD004
MIFTS: 46

Prediabetes Syndrome

Categories: Metabolic diseases

Aliases & Classifications for Prediabetes Syndrome

MalaCards integrated aliases for Prediabetes Syndrome:

Name: Prediabetes Syndrome 12 14 69
Prediabetic State 12 51 41
Prediabetes 12 40

Classifications:



External Ids:

Disease Ontology 12 DOID:11716
ICD10 32 R73.09
MeSH 41 D011236
NCIt 46 C122685
UMLS 69 C0362046

Summaries for Prediabetes Syndrome

MedlinePlus : 40 Prediabetes means you have blood glucose, or blood sugar, levels that are higher than normal but not high enough to be called diabetes. Glucose comes from the foods you eat. Too much glucose in your blood can damage your body over time. If you have prediabetes, you are more likely to develop type 2 diabetes, heart disease, and stroke. Most people with prediabetes don't have any symptoms. Your doctor can use an A1C test or another blood test to find out if your blood glucose levels are higher than normal. If you are 45 years old or older, your doctor may recommend that you be tested for prediabetes, especially if you are overweight. Losing weight - at least 5 to 10 percent of your starting weight - can prevent or delay diabetes or even reverse prediabetes. That's 10 to 20 pounds for someone who weighs 200 pounds. You can lose weight by cutting down on the amount of calories and fat you eat and being physically active at least 30 minutes a day. Being physically active makes your body's insulin work better. Your doctor may also prescribe medicine to help control the amount of glucose in your blood. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Prediabetes Syndrome, also known as prediabetic state, is related to nonalcoholic steatohepatitis and fatty liver disease. An important gene associated with Prediabetes Syndrome is INS (Insulin), and among its related pathways/superpathways are Glucose / Energy Metabolism and AMP-activated Protein Kinase (AMPK) Signaling. The drugs Metformin and Saxagliptin have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia : 72 Prediabetes is the precursor stage before diabetes mellitus in which not all of the symptoms required to... more...

Related Diseases for Prediabetes Syndrome

Diseases related to Prediabetes Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 nonalcoholic steatohepatitis 31.4 ADIPOQ IL6 INS LEP
2 fatty liver disease 31.0 ADIPOQ APOB IL6 INS LEP PPARG
3 gestational diabetes 29.9 ADIPOQ INS LEP TCF7L2
4 deficiency anemia 29.8 ALB CRP IL6
5 hyperuricemia 29.7 APOB CRP INS
6 liver disease 29.3 ADIPOQ ALB IL6 INS LEP
7 diabetes mellitus 29.3 ADIPOQ ALB CRP GAD1 GCG IL6
8 apnea, obstructive sleep 29.2 ADIPOQ CRP IL6 INS LEP
9 sleep apnea 29.2 ADIPOQ CRP IL6 INS LEP
10 coronary heart disease 1 29.2 ADIPOQ APOB COG2 CRP INS
11 cerebrovascular disease 29.1 APOB CRP IL6 INS
12 hypercholesterolemia, familial 29.0 APOB COG2 CRP INS
13 morbid obesity 29.0 ADIPOQ ALB CRP INS LEP PPARG
14 hyperglycemia 29.0 ADIPOQ ALB DPP4 GCG INS LEP
15 heart disease 28.8 ADIPOQ ALB APOB CRP IL6 INS
16 hypertension, essential 28.6 ADIPOQ ALB APOB CRP INS LEP
17 glucose intolerance 28.5 ADIPOQ CRP DPP4 GCG INS LEP
18 coronary artery anomaly 28.4 ADIPOQ APOB COG2 CRP IL6 INS
19 lipid metabolism disorder 28.2 ADIPOQ APOB COG2 CRP INS LEP
20 arteriosclerosis 28.1 ADIPOQ APOB COG2 CRP IL6 INS
21 myocardial infarction 28.0 ADIPOQ ALB APOB COG2 CRP IL6
22 body mass index quantitative trait locus 11 27.6 ADIPOQ APOB COG2 CRP DPP4 GCG
23 arteries, anomalies of 27.3 ADIPOQ ALB APOB COG2 CRP IL6
24 diabetes mellitus, noninsulin-dependent 27.3 ADIPOQ ALB APOB COG2 CRP DPP4
25 malignant otitis externa 10.5 CRP INS
26 autoimmune polyendocrine syndrome, type ii 10.5 GAD1 INS
27 acquired generalized lipodystrophy 10.5 ADIPOQ LEP
28 idiopathic recurrent pericarditis 10.4 ADIPOQ LEP
29 lipodystrophy, familial partial, type 2 10.4 INS LEP
30 idiopathic edema 10.4 ADIPOQ INS PPARG
31 3-hydroxyacyl-coa dehydrogenase deficiency 10.4 ADIPOQ INS PPARG
32 lutheran suppressor, x-linked 10.4 ADIPOQ INS LEP
33 mediastinitis 10.3 CRP INS
34 cold agglutinin disease 10.3 CRP IL6
35 acanthosis nigricans 10.3 ADIPOQ INS LEP
36 type 1 diabetes mellitus 15 10.3 GCG INS
37 familial partial lipodystrophy 10.3 INS LEP PPARG
38 burns 10.3 ALB INS
39 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.3 CRP INS LEP
40 diabetic foot ulcers 10.3 CRP IL6
41 cryopyrin-associated periodic syndrome 10.3 CRP IL6
42 pyuria 10.3 ALB CRP
43 neutrophilia, hereditary 10.3 CRP IL6
44 acute cholangitis 10.3 CRP IL6
45 cardiogenic shock 10.3 CRP IL6
46 obesity-hypoventilation syndrome 10.2 ADIPOQ IL6 LEP
47 severe pre-eclampsia 10.2 ADIPOQ ALB LEP
48 multiple symmetrical lipomatosis 10.2 ADIPOQ IL6 LEP
49 uremic pruritus 10.2 CRP IL6
50 abdominal obesity-metabolic syndrome 1 10.2 ADIPOQ INS LEP PPARG

Graphical network of the top 20 diseases related to Prediabetes Syndrome:



Diseases related to Prediabetes Syndrome

Symptoms & Phenotypes for Prediabetes Syndrome

MGI Mouse Phenotypes related to Prediabetes Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 INS APOB COG2 CRP LEP DPP4
2 growth/size/body region MP:0005378 10.11 INS APOB COG2 DPP4 GAD1 ADIPOQ
3 endocrine/exocrine gland MP:0005379 10.1 INS LEP DPP4 ADIPOQ GAD1 IL6
4 cellular MP:0005384 10.09 ALB APOB INS GAD1 ADIPOQ IL6
5 cardiovascular system MP:0005385 10.06 APOB INS CRP ADIPOQ IL6 TCF7L2
6 adipose tissue MP:0005375 9.95 INS ADIPOQ IL6 TCF7L2 LEP PPARG
7 liver/biliary system MP:0005370 9.91 APOB LEP ADIPOQ IL6 ALB INS
8 muscle MP:0005369 9.76 INS APOB ADIPOQ IL6 ALB TCF7L2
9 neoplasm MP:0002006 9.43 ADIPOQ IL6 ALB TCF7L2 LEP PPARG
10 renal/urinary system MP:0005367 9.17 INS ADIPOQ IL6 ALB TCF7L2 LEP

Drugs & Therapeutics for Prediabetes Syndrome

Drugs for Prediabetes Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 390)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1 657-24-9 4091 14219
2
Saxagliptin Approved Phase 4,Phase 3 361442-04-8 11243969
3
Curcumin Approved, Investigational Phase 4 458-37-7 969516
4
Benzocaine Approved, Investigational Phase 4,Phase 2 1994-09-7, 94-09-7 2337
5
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
6
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
7
Ticagrelor Approved Phase 4 274693-27-5 9871419
8
Ticlopidine Approved Phase 4 55142-85-3 5472
9
Insulin Glargine Approved Phase 4,Phase 3,Phase 1 160337-95-1
10
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6 32051 23994
11
Nitric Oxide Approved Phase 4,Phase 2,Phase 3 10102-43-9 145068
12
Ethanol Approved Phase 4,Phase 3 64-17-5 702
13
Acarbose Approved, Investigational Phase 4,Phase 3 56180-94-0 441184
14
Exenatide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 141758-74-9 15991534
15
Hydroxychloroquine Approved Phase 4 118-42-3 3652
16
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
17
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
18
Rosiglitazone Approved, Investigational Phase 4,Phase 3,Phase 2 122320-73-4 77999
19
Pioglitazone Approved, Investigational Phase 4,Phase 2,Phase 1 111025-46-8 4829
20
Liraglutide Approved Phase 4,Phase 3,Phase 2,Phase 1 204656-20-2 44147092
21
Fluspirilene Approved, Investigational Phase 4 1841-19-6 3396
22
Pravastatin Approved Phase 4 81093-37-0 54687
23
Linagliptin Approved Phase 4 668270-12-0 10096344
24
Adalimumab Approved Phase 4 331731-18-1 16219006
25 tannic acid Approved, Nutraceutical Phase 4,Phase 2
26
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 10883523 5280795 6221
27
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 1406-16-2
28
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
30
Menadione Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-27-5 4055
31
Phytonadione Approved, Investigational, Nutraceutical Phase 4,Phase 1,Phase 2 84-80-0 5284607 4812
32
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
33
Nicotinamide Approved, Investigational, Nutraceutical Phase 4 98-92-0 936
34
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 77-92-9 311
35
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
36
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
37
2,4-thiazolidinedione Investigational Phase 4,Phase 2 2295-31-0
38 Menatetrenone Investigational Phase 4 863-61-6
39 Dipeptidyl-Peptidase IV Inhibitors Phase 4,Phase 3,Phase 2
40 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
41 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
42 Hormones Phase 4,Phase 3,Phase 2,Phase 1
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
44 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Incretins Phase 4,Phase 3,Phase 2,Phase 1
46
protease inhibitors Phase 4,Phase 3,Phase 2
47 Sitagliptin Phosphate Phase 4,Phase 3,Phase 2
48 Analgesics Phase 4,Phase 2,Phase 1
49 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 1
50 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 683)

# Name Status NCT ID Phase Drugs
1 Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity Unknown status NCT01960205 Phase 4 Saxagliptin;saxagliptin;metformin
2 Sitagliptin and Brown Adipose Tissue Unknown status NCT02294084 Phase 4 Sitagliptin;placebo
3 Curcumin Therapy in Patients With Impaired Glucose Tolerance and Insulin Resistance Unknown status NCT01052025 Phase 4 Curcumin
4 Intensity of Exercise and Glucose Metabolism Unknown status NCT01649219 Phase 4
5 Insulin Resistance and Mild Cognitive Impairment (IRMCI) Study Unknown status NCT02409238 Phase 4 Metformin
6 PRotective Effect on the Coronary Microcirculation of Patients With DIabetes by Clopidogrel or Ticagrelor Unknown status NCT02698618 Phase 4 Randomization
7 Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD) Unknown status NCT01035528 Phase 4 insulin glargine;metformin
8 Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and Diabetes Unknown status NCT02236481 Phase 4 Anakinra;TNF alpha inhibitors
9 Effect of Atorvastatin on Glycemic Control in Prediabetic Patients Completed NCT02470455 Phase 4 Atorvastatin
10 Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients With Prediabetes Completed NCT02700334 Phase 4 Dapagliflozin;Placebo
11 Effects of Antidiabetic Medications on the Postprandial State in Prediabetes Completed NCT02104739 Phase 4 Exenatide;Saxagliptin;Exenatide ER
12 Effect of Rubus Occidentalis Extract on Plasma Glucose Levels in Subject With Prediabetes Completed NCT01964703 Phase 4 Rubus occidentalis extract
13 Metformin and Longevity Genes in Prediabetes Completed NCT01765946 Phase 4 Metformin;placebo
14 Evaluating the Effects of a Diet and Exercise Program in People With Type 2 Diabetes or Prediabetes: (The SHAPE3 Study) Completed NCT00928005 Phase 4
15 Oral Cholecalciferol in Prevention of Type 2 Diabetes Mellitus Completed NCT01436916 Phase 4 oral cholecalciferol + life style counselling;placebo + life style counselling
16 Effect of Anthocyanins on Metabolic Profiles in Subjects With Pre-diabetes Completed NCT02689765 Phase 4
17 Development of Pre-pregnancy Intervention to Reduce the Risk of Diabetes and Prediabetes Completed NCT02617693 Phase 4
18 Effects of Vitamin D on Beta Cell Function and Insulin Sensitivity in Pre-diabetes and Diabetes Mellitus Type 2 Completed NCT01497132 Phase 4 Vitamin D3;Placebo
19 Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes Completed NCT01326533 Phase 4 hydroxychloroquine
20 Acute Impact of Intramuscular (IM) Aripiprazole and Olanzapine on Insulin Resistance in High Risk Prediabetics Completed NCT01411930 Phase 4 Intramuscular olanzapine, aripiprazole;Intramuscular aripiprazole, olanzapine
21 Physical Exercise Versus Rosiglitazone in CAD and Prediabetes Completed NCT00675740 Phase 4 rosiglitazone
22 Evaluation of the Translation of the DE-PLAN Program for the Primary Prevention of Type 2 Diabetes in Routine Primary Care Completed NCT01365013 Phase 4
23 The Vascular Effects of Exenatide Versus Metformin in Patients With Pre-Diabetes Completed NCT00546728 Phase 4 Exenatide;Metformin
24 Study to Determine the Effects of Human Growth Hormone and Pioglitazone in Overweight, Prediabetic Adults Completed NCT00352287 Phase 4 Recombinant human growth hormone; pioglitazone
25 Incretins in Impaired Fasting Glucose Completed NCT00364377 Phase 4 Sitagliptin
26 Mechanisms Underlying Metabolic Syndrome in Obesity Completed NCT00579813 Phase 4 Pioglitazone
27 The Effect of A-lipoic Acid (ALA) on Fatty Acid-induced Impairment of Glucose-stimulated Insulin Secretion Completed NCT01056497 Phase 4 alpha lipoic acid
28 The Effect of Vitamin K Supplementation on Glucose Metabolism Completed NCT00960973 Phase 4 Menatetrenone;Placebo
29 The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes Completed NCT01181986 Phase 4 Exenatide SC;Exenatide IV;Placebo SC;Exendin-9;Placebo IV
30 Effect of DPP4 Inhibition on Growth Hormone Secretion Completed NCT01701973 Phase 4 Sitagliptin;Pegvisomant;Placebo;L-NMMA;Exendin 9-39
31 Metformin in Insulin Resistant Left Ventricular (LV) Dysfunction (TAYSIDE Trial) Completed NCT00473876 Phase 4 Metformin;Matched Placebo (Capsules)
32 Niacin, N-3 Fatty Acids and Insulin Resistance Completed NCT00286234 Phase 4 omega-3 acid ethyl esters;extended release niacin;placebo;omega-3 acid ethyl esters;combined treatment
33 University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial) Completed NCT00994682 Phase 4 Pioglitazone study drug;Placebo;Pioglitazone Open Label
34 Sitagliptin + Metformin Compared to Metformin Monotherapy and Placebo in Women With a Recent GDM Completed NCT01856907 Phase 4 Sitagliptin-Metformin;Metformin;Placebo pill
35 Treatment With Sitagliptin for Reactive Hypoglycemia Secondary to Dysinsulinism Completed NCT00847080 Phase 4 Sitagliptin phosphate;Placebo
36 Coronary Artery Disease Progression in Patients With Prediabetes Recruiting NCT02744976 Phase 4 Metformin
37 Improving Beta Cell Function in Mexican American Women With Prediabetes Recruiting NCT02488057 Phase 4 Liraglutide
38 Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes Recruiting NCT02754739 Phase 4 Pravastatin;Placebo (for Pravastatin)
39 Dapagliflozin in Type 2 Diabetes or Pre-diabetes, and PRESERVED Ejection Fraction Heart Failure Recruiting NCT03030235 Phase 4 Dapagliflozin 10Mg Oral Tablet;Dapagliflozin matching placebo
40 Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients. Recruiting NCT03398356 Phase 4 Metformin
41 Metformin in Co-morbid Diabetes or Prediabetes and Serious Mental Illness Recruiting NCT02167620 Phase 4 Metformin;Placebo
42 Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis Recruiting NCT02051842 Phase 4 Metadoxine
43 Efficacy of Metformin in Preventing Diabetes in China Recruiting NCT03441750 Phase 4 metformin
44 Hospital-based Diabetes Prevention Study in Korea Recruiting NCT02981121 Phase 4 Metformin
45 Cardiovascular Effects of GLP-1 Receptor Activation Recruiting NCT03101930 Phase 4 Liraglutide;Sitagliptin;Placebos;Exendin (9-39)
46 Effect of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes Active, not recruiting NCT03029390 Phase 4 Metformin
47 Effect of Dapagliflozin on Blood Pressure Variability in Prediabetes and Prehypertension Active, not recruiting NCT03006471 Phase 4 Dapagliflozin;Placebo - Cap
48 Effect of Linagliptin + Metformin vs Metformin Alone in Patients With Prediabetes Active, not recruiting NCT03004612 Phase 4 Linagliptin + metformin
49 Metformin in Longevity Study Active, not recruiting NCT02432287 Phase 4 Metformin;Placebo
50 MetfoRmin and Its Effects on Left Ventricular Hypertrophy in Normotensive Patients With Coronary Artery Disease Active, not recruiting NCT02226510 Phase 4 Metformin XL;Placebo

Search NIH Clinical Center for Prediabetes Syndrome

Cochrane evidence based reviews: prediabetic state

Genetic Tests for Prediabetes Syndrome

Anatomical Context for Prediabetes Syndrome

MalaCards organs/tissues related to Prediabetes Syndrome:

38
Testes, Heart, Kidney, Endothelial, Bone, Skeletal Muscle, Liver

Publications for Prediabetes Syndrome

Articles related to Prediabetes Syndrome:

# Title Authors Year
1
Cardiovascular risk factors and the prediabetic syndrome. ( 8862692 )
1996

Variations for Prediabetes Syndrome

Expression for Prediabetes Syndrome

Search GEO for disease gene expression data for Prediabetes Syndrome.

Pathways for Prediabetes Syndrome

Pathways related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1 12.31 ADIPOQ GAD1 GCG INS PPARG
2
Show member pathways
12.21 ADIPOQ INS LEP PPARG
3
Show member pathways
12.1 ALB APOB CRP IL6 INS
5 11.82 ALB IL6 INS
6 11.78 ADIPOQ IL6 INS LEP PPARG
7 11.54 ADIPOQ IL6 INS LEP PPARG
8
Show member pathways
11.37 DPP4 GCG LEP TCF7L2
9
Show member pathways
11.36 DPP4 GCG INS LEP SLC30A8 TCF7L2
10
Show member pathways
11.3 APOB GCG INS
11 10.98 ADIPOQ LEP PPARG
12 10.79 CRP IL6
13 10.6 ADIPOQ IL6 LEP PPARG

GO Terms for Prediabetes Syndrome

Cellular components related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 ADIPOQ ALB APOB CRP GCG IL6
2 endoplasmic reticulum lumen GO:0005788 9.55 ALB APOB GCG IL6 INS
3 extracellular region GO:0005576 9.32 ADIPOQ ALB APOB CRP DPP4 GCG
4 endosome lumen GO:0031904 9.26 APOB INS

Biological processes related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 APOB CRP IL6 INS
2 regulation of receptor activity GO:0010469 9.8 ADIPOQ GCG IL6 INS LEP
3 cellular protein metabolic process GO:0044267 9.76 ALB APOB IL6 INS
4 positive regulation of MAPK cascade GO:0043410 9.73 IL6 INS LEP
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 ADIPOQ IL6 INS
6 response to nutrient GO:0007584 9.7 ADIPOQ LEP PPARG
7 response to glucose GO:0009749 9.69 ADIPOQ SLC30A8 TCF7L2
8 regulation of insulin secretion GO:0050796 9.67 DPP4 GCG LEP
9 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.63 ADIPOQ PPARG
10 positive regulation of JAK-STAT cascade GO:0046427 9.62 IL6 LEP
11 lipoprotein transport GO:0042953 9.62 APOB PPARG
12 positive regulation of cellular protein metabolic process GO:0032270 9.61 ADIPOQ INS
13 fatty acid oxidation GO:0019395 9.61 ADIPOQ PPARG
14 glucose metabolic process GO:0006006 9.61 ADIPOQ INS LEP
15 regulation of fat cell differentiation GO:0045598 9.6 LEP PPARG
16 negative regulation of collagen biosynthetic process GO:0032966 9.59 IL6 PPARG
17 locomotory exploration behavior GO:0035641 9.58 DPP4 GAD1
18 negative regulation of gluconeogenesis GO:0045721 9.58 ADIPOQ INS
19 positive regulation of insulin receptor signaling pathway GO:0046628 9.57 INS LEP
20 negative regulation of blood vessel diameter GO:0097756 9.54 CRP INS
21 negative regulation of acute inflammatory response GO:0002674 9.48 INS PPARG
22 acute-phase response GO:0006953 9.43 CRP IL6 INS
23 positive regulation of STAT protein import into nucleus GO:2000366 9.37 IL6 LEP
24 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.33 ADIPOQ CRP PPARG
25 cellular response to prostaglandin stimulus GO:0071379 9.32 APOB PPARG
26 negative regulation of lipid storage GO:0010888 9.13 CRP IL6 LEP
27 glucose homeostasis GO:0042593 9.1 ADIPOQ INS LEP PPARG SLC30A8 TCF7L2

Molecular functions related to Prediabetes Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 ADIPOQ ALB CRP DPP4 GCG INS
2 low-density lipoprotein particle receptor binding GO:0050750 9.16 APOB CRP
3 hormone activity GO:0005179 8.92 ADIPOQ GCG INS LEP

Sources for Prediabetes Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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