MCID: PRC031
MIFTS: 55

Preeclampsia/eclampsia 1

Categories: Genetic diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Preeclampsia/eclampsia 1

MalaCards integrated aliases for Preeclampsia/eclampsia 1:

Name: Preeclampsia/eclampsia 1 54 29 13
Preeclampsia 54 25 56 29 52
Toxemia of Pregnancy 25 29
Pre-Eclampsia 25 69
Gestational Proteinuric Hypertension 25
Pregnancy Associated Hypertension 69
Hypertension, Pregnancy-Induced 54
Pregnancy-Induced Hypertension 25
Pregnancy Toxemias 52

Characteristics:

OMIM:

54
Inheritance:
autosomal dominant

Miscellaneous:
majority of cases are sporadic
occurs in ~3% pregnancies in western populations
clinical manifestation ranges from mild, transient hypertension to hellp syndrome (hemolysis, elevated liver enzymes, and low platelets)


HPO:

32
preeclampsia/eclampsia 1:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Preeclampsia/eclampsia 1

OMIM : 54
Preeclampsia, which along with chronic hypertension and gestational hypertension comprise the hypertensive disorders of pregnancy, is characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. Preeclampsia is 1 of the top 4 causes of maternal mortality and morbidity worldwide (summary by Payne et al., 2011). Preeclampsia is otherwise known as gestational proteinuric hypertension (Davey and MacGillivray, 1988). A high proportion of patients with preeclampsia have glomerular endotheliosis, the unique histopathologic feature of the condition (Fisher et al., 1981). A distinct form of severe preeclampsia is characterized by hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome) (Brown et al., 2000). (189800)

MalaCards based summary : Preeclampsia/eclampsia 1, also known as preeclampsia, is related to pyelonephritis and mitral valve stenosis, and has symptoms including seizures, thrombocytopenia and proteinuria. An important gene associated with Preeclampsia/eclampsia 1 is NOS3 (Nitric Oxide Synthase 3), and among its related pathways/superpathways are VEGF Pathway (Qiagen) and VEGF Signaling Pathway. The drugs Methyldopa and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and testes, and related phenotypes are cardiovascular system and embryo

Genetics Home Reference : 25 Preeclampsia is a complication of pregnancy in which affected women develop high blood pressure (hypertension); they can also have abnormally high levels of protein in their urine (proteinuria). This condition usually occurs in the last few months of pregnancy and often requires early delivery of the infant.

Related Diseases for Preeclampsia/eclampsia 1

Diseases in the Preeclampsia/eclampsia 1 family:

Preeclampsia/eclampsia 2 Preeclampsia/eclampsia 5
Preeclampsia/eclampsia 3 Preeclampsia/eclampsia 4

Diseases related to Preeclampsia/eclampsia 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
id Related Disease Score Top Affiliating Genes
1 pyelonephritis 30.4 EDN1 NOS3 SERPINC1
2 mitral valve stenosis 30.3 ENG FLT1 VEGFA
3 myocardial infarction 29.4 EDN1 F5 MTHFR NOS3 PGF SERPINC1
4 preeclampsia/eclampsia 5 12.1
5 preeclampsia/eclampsia 4 12.0
6 preeclampsia/eclampsia 2 11.8
7 preeclampsia/eclampsia 3 11.8
8 hellp syndrome 11.3
9 pre-eclampsia 11.2
10 antiphospholipid syndrome 11.1
11 mcgillivray syndrome 10.9 APOH F5
12 multicentric osteolysis nephropathy 10.9 F5 MTHFR
13 progressive black carbon hyperpigmentation of infancy 10.8 EDN1 NOS3
14 sydenham chorea 10.8 ENG FLT1 PGF
15 hypertonia 10.8 MTHFR NOS3 VEGFA
16 salivary gland adenoid cystic carcinoma 10.8 ENG FLT1 VEGFA
17 superior limbic keratoconjunctivitis 10.8 F5 MTHFR SERPINC1
18 collagenous colitis 10.8 APOH F5 SERPINC1
19 follicular adenoma 10.8 F5 MTHFR SERPINC1
20 glutathioninuria 10.8 APOH F5 SERPINC1
21 coronary sinus stenosis 10.8 F5 MTHFR
22 acitretin/etretinate embryopathy 10.8 FLT1 PGF VEGFA
23 myxomatous pattern testicular yolk sac tumor 10.8 APOH F5 NOS3
24 coloboma of superior eyelid 10.8 FLT1 PGF VEGFA
25 accessory deep peroneal nerve 10.8 APOH F5
26 angioedema, hereditary, type iii 10.8 APOH F5 SERPINC1
27 lockwood feingold syndrome 10.8 APOH F5 MTHFR
28 elejalde disease 10.8 APOH MTHFR NOS3
29 congenital syphilis 10.8 APOH F5 SERPINC1
30 traumatic glaucoma 10.8 EDN1 NOS3 PGF
31 stickler sydrome, type i, nonsyndromic ocular 10.8 APOH F5 SERPINC1
32 lethal congenital contractural syndrome 2 10.8 EDN1 NOS3 VEGFA
33 mthfr thermolabile variant 10.8
34 severe pre-eclampsia 10.8
35 spinal cord lipoma 10.8 APOH MTHFR SERPINC1
36 hepatocellular adenoma 10.8 F5 MTHFR NOS3
37 cavernous lymphangioma 10.8 APOH F5 MTHFR
38 central retinal artery occlusion 10.7 APOH MTHFR SERPINC1
39 glomerulosclerosis, focal segmental, 2 10.7 APOH F5 SERPINC1
40 aryepiglottic fold cancer 10.7 F5 MTHFR SERPINC1
41 leukorrhea 10.7 F5 MTHFR SERPINC1
42 ischemic heart disease 10.7 APOH SERPINC1 VEGFA
43 stoll alembik finck syndrome 10.7 F5 SERPINC1
44 kidney pelvis papillary carcinoma 10.7 FLT1 VEGFA
45 amelogenesis imperfecta hypomaturation type 10.7 F5 MTHFR
46 ocular hyperemia 10.7 F5 MTHFR SERPINC1
47 citrullinemia, adult-onset type ii 10.7 FLT1 NOS3 PGF VEGFA
48 esophageal leukoplakia 10.7 EDN1 NOS3 VEGFA
49 syncope 10.7 APOH F5 MTHFR SERPINC1
50 priapism 10.7 F5 MTHFR NOS3 SERPINC1

Graphical network of the top 20 diseases related to Preeclampsia/eclampsia 1:



Diseases related to Preeclampsia/eclampsia 1

Symptoms & Phenotypes for Preeclampsia/eclampsia 1

Symptoms via clinical synopsis from OMIM:

54

Laboratory- Abnormalities:
proteinuria
elevated liver enzymes

Muscle Soft Tissue:
edema

Growth- Other:
intrauterine growth retardation (in fetus)

Cardiovascular- Vascular:
maternal hypertension (after 20th week gestation, resolved postpartum)

Hematology:
thrombocytopenia (hellp syndrome)

Genitourinary- Kidneys:
proteinuria

Abdomen- Liver:
elevated liver enzymes

Prenatal Manifestations- Maternal:
maternal hypertension (after 20th week gestation, resolved postpartum)

Neurologic- Central Nervous System:
seizures (eclampsia)


Clinical features from OMIM:

189800

Human phenotypes related to Preeclampsia/eclampsia 1:

32 (show all 10)
id Description HPO Frequency HPO Source Accession
1 seizures 32 HP:0001250
2 thrombocytopenia 32 HP:0001873
3 proteinuria 32 HP:0000093
4 intrauterine growth retardation 32 HP:0001511
5 hypertension 32 HP:0000822
6 edema 32 HP:0000969
7 preeclampsia 32 HP:0100602
8 elevated hepatic transaminases 32 HP:0002910
9 eclampsia 32 HP:0100601
10 maternal hypertension 32 HP:0008071

UMLS symptoms related to Preeclampsia/eclampsia 1:


edema, hyperemesis gravidarum, morning sickness

MGI Mouse Phenotypes related to Preeclampsia/eclampsia 1:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 CORIN EDN1 ENG F5 FLT1 LEP
2 embryo MP:0005380 9.76 FLT1 LEP PGF SERPINC1 VEGFA EDN1
3 growth/size/body region MP:0005378 9.7 CORIN EDN1 ENG F5 FLT1 LEP
4 homeostasis/metabolism MP:0005376 9.55 PIGF SERPINC1 TAC3 VEGFA APOH CORIN

Drugs & Therapeutics for Preeclampsia/eclampsia 1

Drugs for Preeclampsia/eclampsia 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 385)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4,Phase 2,Phase 1 555-30-6 38853
2
Remifentanil Approved Phase 4,Phase 2,Phase 1 132875-61-7 60815
3
Selenium Approved, Vet_approved Phase 4,Phase 2,Phase 3 7782-49-2
4
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 14219 4091
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
6
Dalteparin Approved Phase 4,Phase 2,Phase 3 9005-49-6
7
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3 9005-49-6 772 46507594
8
Zinc Approved Phase 4,Phase 2,Phase 3 7440-66-6 32051 23994
9
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
10
Oxymetazoline Approved Phase 4 1491-59-4 4636
11
Phenylephrine Approved Phase 4 59-42-7 6041
12
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
13
Labetalol Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 36894-69-6 3869
14
Misoprostol Approved Phase 4,Phase 3,Phase 1,Phase 2 59122-46-2 5282381
15
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 7487-88-9 24083
16
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 2180-92-9, 38396-39-3 2474
17
Levobupivacaine Approved Phase 4 27262-47-1 92253
18
Furosemide Approved, Vet_approved Phase 4,Phase 2 54-31-9 3440
19
Captopril Approved Phase 4 62571-86-2 44093
20
Clonidine Approved Phase 4,Phase 1,Phase 2 4205-90-7 2803
21
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
22
Insulin Aspart Approved Phase 4 116094-23-6 16132418
23
Insulin Lispro Approved Phase 4 133107-64-9
24
Glyburide Approved Phase 4 10238-21-8 3488
25
Calcium Carbonate Approved Phase 4 471-34-1
26
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
27
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
28
Nifedipine Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 21829-25-4 4485
29
Thrombin Approved Phase 4
30
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
31
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
32
Desogestrel Approved Phase 4 54024-22-5 40973
33
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
34
Amlodipine Approved Phase 4 88150-42-9 2162
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1 59-30-3 6037
36
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 143 6006
37
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 67-97-0 6221 10883523 5280795
38
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 50-14-6 5280793
39
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 1406-16-2
40 tannic acid Approved, Nutraceutical Phase 4,Phase 3
41 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
42 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1
44 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Phase 1
45 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Phase 1
46 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
47 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Sympatholytics Phase 4,Phase 2,Phase 1,Early Phase 1
50 Analgesics Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 533)

id Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia Unknown status NCT00117546 Phase 4 alpha methyldopa
3 Remifentanil for General Anesthesia in Preeclamptics Unknown status NCT00567957 Phase 4 Remifentanil;Saline
4 Viagra for the Treatment of IUGR Unknown status NCT00347867 Phase 4 Viagra administration in IUGR/PET pregnancies
5 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
6 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
7 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
8 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
9 Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
10 A Study of Cerebral-circulatory Response to Intravenous Antihypertensive Treatment in Women With Serious Preeclampsia Completed NCT00403572 Phase 4
11 Hemodynamic Measurements in Women With Serious Preeclampsia Completed NCT00199810 Phase 4
12 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
13 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid;Acetylsalicylic Acid
14 Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
15 A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
16 Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
17 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
18 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
19 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4 metformin;insulin
20 Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients Completed NCT02466204 Phase 4 corifollitropin alfa;Follitropin Beta
21 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4 Glyburide;Placebo
22 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Recruiting NCT03233880 Phase 4 Azithromycin 1gm
23 Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Recruiting NCT03164304 Phase 4 Magnesium Sulfate
24 Low Dose Calcium to Prevent Preeclampsia Recruiting NCT02338687 Phase 4
25 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
26 Phenylephrine Versus Ephedrine in Pre-eclampsia Recruiting NCT02025426 Phase 4 Phenylephrine;Ephedrine
27 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Recruiting NCT02891174 Phase 4 Ibuprofen;Acetaminophen
28 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
29 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
30 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Recruiting NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
31 Chronotherapy With Low-dose Aspirin for Primary Prevention Recruiting NCT00725127 Phase 4 aspirin;aspirin
32 Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Recruiting NCT03177122 Phase 4 Myo-inositol
33 A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor Recruiting NCT02777190 Phase 4 Misoprostol
34 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
35 Pharmacokinetics of Amlodipine Besylate at Delivery and During Lactation Active, not recruiting NCT02353806 Phase 4 Amlodipine besylate
36 Effect of Administering Intravenous Magnesium Sulfate on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients Not yet recruiting NCT03237000 Phase 4 MgSO4
37 Failure Rate of GLyburide And Metformin Among Gestational Diabetics Not yet recruiting NCT03078725 Phase 4 Glyburide;Metformin
38 LMWH to Prevent Preeclampsia and Fetal Growth Restriction Terminated NCT00260520 Phase 4 Dalteparin
39 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
40 Comparison of Awakening Versus Bedtime Dosing of Aspirin in Pre-Hypertension or Mild Essential Hypertension Terminated NCT00449618 Phase 4 Aspirin 100 mg;Placebo
41 Atenativ Effect on Uterine Blood Flow and Preeclampsia Withdrawn NCT02278575 Phase 4 Atenativ
42 Low Dose Aspirin for the Prevention of Preeclampsia Unknown status NCT01890005 Phase 3 Aspirin;Placebo
43 PP13 and Doppler Study to Predict Preeclampsia Unknown status NCT00928213 Phase 2, Phase 3 Progesterone;Low molecular weight Heparin;No Drug
44 Investigating the Novel Observation of Right-Left Difference in Uterine Artery Vascular Resistance in Pre-Eclampsia Unknown status NCT00848679 Phase 3 Epidural lidocaine;Epidural lidocaine 2%
45 Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia Unknown status NCT01382732 Phase 3 Carbetocin;Oxytocin
46 Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine Unknown status NCT00409253 Phase 3 URAPIDIL (EUPRESSYL*);NICARDIPINE
47 Randomized Clinical Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients. Unknown status NCT02050529 Phase 2, Phase 3 Labetalol;Hydralazine
48 A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy Unknown status NCT02032186 Phase 3 Magnesium citrate
49 Effect of Micronutrients and Exercise During Pregnancy on Factors Related With Non-Transmissible Chronic Diseases Unknown status NCT00872365 Phase 2, Phase 3
50 Heparin for Pregnant Women With Thrombophilia Unknown status NCT01019655 Phase 3 Nadroparin calcium

Search NIH Clinical Center for Preeclampsia/eclampsia 1

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Preeclampsia/eclampsia 1

Genetic tests related to Preeclampsia/eclampsia 1:

id Genetic test Affiliating Genes
1 Preeclampsia/eclampsia 1 29
2 Toxemia of Pregnancy 29
3 Preeclampsia 29

Anatomical Context for Preeclampsia/eclampsia 1

MalaCards organs/tissues related to Preeclampsia/eclampsia 1:

39
Liver, Endothelial, Testes, Placenta, Thyroid, Heart, Brain

Publications for Preeclampsia/eclampsia 1

Variations for Preeclampsia/eclampsia 1

ClinVar genetic disease variations for Preeclampsia/eclampsia 1:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NOS3 NM_000603.4(NOS3): c.894T> G (p.Asp298Glu) single nucleotide variant risk factor rs1799983 GRCh37 Chromosome 7, 150696111: 150696111
2 NSD1 NM_022455.4(NSD1): c.6050G> A (p.Arg2017Gln) single nucleotide variant Pathogenic/Likely pathogenic rs587784177 GRCh37 Chromosome 5, 176710828: 176710828

Copy number variations for Preeclampsia/eclampsia 1 from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 44882 10 64500000 74900000 Loss STOX1 Preeclampsia

Expression for Preeclampsia/eclampsia 1

Search GEO for disease gene expression data for Preeclampsia/eclampsia 1.

Pathways for Preeclampsia/eclampsia 1

GO Terms for Preeclampsia/eclampsia 1

Cellular components related to Preeclampsia/eclampsia 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 APOH CORIN EDN1 F5 FLT1 LEP
2 extracellular space GO:0005615 9.32 APOH EDN1 ENG F5 FLT1 LEP

Biological processes related to Preeclampsia/eclampsia 1 according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 EDN1 FLT1 LEP PGF STOX1 VEGFA
2 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.72 FLT1 PGF VEGFA
3 response to hypoxia GO:0001666 9.72 EDN1 LEP MTHFR PGF VEGFA
4 positive regulation of MAP kinase activity GO:0043406 9.65 EDN1 FLT1 VEGFA
5 positive regulation of angiogenesis GO:0045766 9.65 ENG FLT1 NOS3 PGF VEGFA
6 angiogenesis GO:0001525 9.63 ENG FLT1 LEP NOS3 PGF VEGFA
7 regulation of blood vessel size GO:0050880 9.58 EDN1 NOS3
8 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.58 FLT1 VEGFA
9 induction of positive chemotaxis GO:0050930 9.57 PGF VEGFA
10 negative regulation of blood coagulation GO:0030195 9.56 APOH EDN1
11 response to transforming growth factor beta GO:0071559 9.54 EDN1 ENG
12 branching involved in blood vessel morphogenesis GO:0001569 9.54 EDN1 ENG VEGFA
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.52 HLA-G LNPEP
14 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.51 APOH EDN1
15 ovulation from ovarian follicle GO:0001542 9.49 LEP NOS3
16 positive regulation of mast cell chemotaxis GO:0060754 9.46 PGF VEGFA
17 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.43 EDN1 NOS3
18 female pregnancy GO:0007565 9.35 CORIN LEP LNPEP PGF TAC3
19 regulation of blood pressure GO:0008217 9.02 CORIN EDN1 LEP LNPEP NOS3

Molecular functions related to Preeclampsia/eclampsia 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.26 APOH PGF SERPINC1 VEGFA
2 vascular endothelial growth factor receptor binding GO:0005172 8.62 PGF VEGFA

Sources for Preeclampsia/eclampsia 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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