MCID: PRC031
MIFTS: 41

Preeclampsia/eclampsia 1

Categories: Genetic diseases

Aliases & Classifications for Preeclampsia/eclampsia 1

MalaCards integrated aliases for Preeclampsia/eclampsia 1:

Name: Preeclampsia/eclampsia 1 53 28 13
Toxemia of Pregnancy 53 28
Pre-Eclampsia 69
Preg1 53
Pee1 53
Pee 53

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant

Miscellaneous:
majority of cases are sporadic
occurs in ~3% pregnancies in western populations
clinical manifestation ranges from mild, transient hypertension to hellp syndrome (hemolysis, elevated liver enzymes, and low platelets)


HPO:

31
preeclampsia/eclampsia 1:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Preeclampsia/eclampsia 1

OMIM : 53 Preeclampsia, which along with chronic hypertension and gestational hypertension comprise the hypertensive disorders of pregnancy, is characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. Preeclampsia is 1 of the top 4 causes of maternal mortality and morbidity worldwide (summary by Payne et al., 2011). Preeclampsia is otherwise known as gestational proteinuric hypertension (Davey and MacGillivray, 1988). A high proportion of patients with preeclampsia have glomerular endotheliosis, the unique histopathologic feature of the condition (Fisher et al., 1981). A distinct form of severe preeclampsia is characterized by hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome) (Brown et al., 2000). (189800)

MalaCards based summary : Preeclampsia/eclampsia 1, also known as toxemia of pregnancy, is related to eclampsia and pre-eclampsia, and has symptoms including edema, seizures and hypertension. An important gene associated with Preeclampsia/eclampsia 1 is NOS3 (Nitric Oxide Synthase 3). The drugs Methyldopa and Calcium Carbonate have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and testes.

Related Diseases for Preeclampsia/eclampsia 1

Diseases in the Preeclampsia/eclampsia 1 family:

Preeclampsia/eclampsia 2 Preeclampsia/eclampsia 3
Preeclampsia/eclampsia 4 Preeclampsia/eclampsia 5

Diseases related to Preeclampsia/eclampsia 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 eclampsia 30.9 EPHX1 PEE1
2 pre-eclampsia 30.3 EPHX1 NOS3 PEE1
3 thrombotic thrombocytopenic purpura 11.0
4 hepatitis 10.0
5 hepatic encephalopathy 10.0
6 encephalopathy 10.0
7 celiac disease 1 9.9
8 anosmia 9.9

Graphical network of the top 20 diseases related to Preeclampsia/eclampsia 1:



Diseases related to Preeclampsia/eclampsia 1

Symptoms & Phenotypes for Preeclampsia/eclampsia 1

Symptoms via clinical synopsis from OMIM:

53
Muscle Soft Tissue:
edema

Laboratory Abnormalities:
proteinuria
elevated liver enzymes

Cardiovascular Vascular:
maternal hypertension (after 20th week gestation, resolved postpartum)

Abdomen Liver:
elevated liver enzymes

Hematology:
thrombocytopenia (hellp syndrome)

Genitourinary Kidneys:
proteinuria

Growth Other:
intrauterine growth retardation (in fetus)

Prenatal Manifestations Maternal:
maternal hypertension (after 20th week gestation, resolved postpartum)

Neurologic Central Nervous System:
seizures (eclampsia)


Clinical features from OMIM:

189800

Human phenotypes related to Preeclampsia/eclampsia 1:

31 (show all 10)
# Description HPO Frequency HPO Source Accession
1 edema 31 HP:0000969
2 seizures 31 HP:0001250
3 hypertension 31 HP:0000822
4 proteinuria 31 HP:0000093
5 intrauterine growth retardation 31 HP:0001511
6 elevated hepatic transaminases 31 HP:0002910
7 thrombocytopenia 31 HP:0001873
8 preeclampsia 31 HP:0100602
9 eclampsia 31 HP:0100601
10 maternal hypertension 31 HP:0008071

UMLS symptoms related to Preeclampsia/eclampsia 1:


hyperemesis gravidarum, edema

Drugs & Therapeutics for Preeclampsia/eclampsia 1

Drugs for Preeclampsia/eclampsia 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 394)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4,Phase 2,Phase 1 555-30-6 38853
2
Calcium Carbonate Approved, Investigational Phase 4,Phase 3 471-34-1
3
Remifentanil Approved Phase 4,Phase 2,Phase 1 132875-61-7 60815
4
Metformin Approved Phase 4,Phase 3,Phase 2 657-24-9 4091 14219
5
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
6
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2 38396-39-3, 2180-92-9 2474
7
Dalteparin Approved Phase 4,Phase 2,Phase 3 9005-49-6
8
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3 9005-49-6 46507594 772
9
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3 7440-66-6 32051 23994
10
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294
11
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
12
Phenylephrine Approved Phase 4 59-42-7 6041
13
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2 90-82-4 7028
14
Labetalol Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 36894-69-6 3869
15
Misoprostol Approved Phase 4,Phase 3,Phase 1,Phase 2 59122-46-2 5282381
16
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 7487-88-9 24083
17
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
18
Furosemide Approved, Vet_approved Phase 4,Phase 2 54-31-9 3440
19
Captopril Approved Phase 4 62571-86-2 44093
20
Clonidine Approved Phase 4,Phase 1,Phase 2 4205-90-7 2803
21
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
22
Insulin Aspart Approved Phase 4,Phase 3 116094-23-6 16132418
23
Insulin Lispro Approved Phase 4 133107-64-9
24
Glyburide Approved Phase 4 10238-21-8 3488
25
Nifedipine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 21829-25-4 4485
26
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
27
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
28
Thrombin Approved, Investigational Phase 4
29
Azithromycin Approved Phase 4,Phase 3 83905-01-5 53477736 447043 55185
30
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
31
Desogestrel Approved Phase 4 54024-22-5 40973
32
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
33
Amlodipine Approved Phase 4 88150-42-9 2162
34
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 77-92-9 311
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
36
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 143 6006
37
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 67-97-0 10883523 5280795 6221
38
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 50-14-6 5280793
39
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 1406-16-2
40 tannic acid Approved, Nutraceutical Phase 4,Phase 3
41 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
42 Bone Density Conservation Agents Phase 4,Phase 3,Phase 1,Phase 2
43 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 Adrenergic Agonists Phase 4,Phase 2,Phase 3,Phase 1
46 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Phase 3,Phase 1
47 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 3,Phase 1
48 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
49 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 565)

# Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Low Dose Calcium to Prevent Preeclampsia Unknown status NCT02338687 Phase 4
3 Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia Unknown status NCT00117546 Phase 4 alpha methyldopa
4 Remifentanil for General Anesthesia in Preeclamptics Unknown status NCT00567957 Phase 4 Remifentanil;Saline
5 Viagra for the Treatment of IUGR Unknown status NCT00347867 Phase 4 Viagra administration in IUGR/PET pregnancies
6 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
7 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
8 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
9 Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
10 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
11 A Study of Cerebral-circulatory Response to Intravenous Antihypertensive Treatment in Women With Serious Preeclampsia Completed NCT00403572 Phase 4
12 Hemodynamic Measurements in Women With Serious Preeclampsia Completed NCT00199810 Phase 4
13 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid;Acetylsalicylic Acid
14 Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
15 A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
16 Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
17 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
18 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
19 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4 metformin;insulin
20 Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients Completed NCT02466204 Phase 4 corifollitropin alfa;Follitropin Beta
21 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4 Glyburide;Placebo
22 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Recruiting NCT03233880 Phase 4 Azithromycin 1gm
23 Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Recruiting NCT03164304 Phase 4 Magnesium Sulfate
24 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
25 Phenylephrine Versus Ephedrine in Pre-eclampsia Recruiting NCT02025426 Phase 4 Phenylephrine;Ephedrine
26 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
27 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Recruiting NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
28 Chronotherapy With Low-dose Aspirin for Primary Prevention Recruiting NCT00725127 Phase 4 aspirin;aspirin
29 Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Recruiting NCT03177122 Phase 4 Myo-inositol
30 A Comparison of Oral Misoprostol and Vaginal Misoprostol for Cervical Ripening and Induction of Labor Recruiting NCT02777190 Phase 4 Misoprostol
31 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Active, not recruiting NCT02891174 Phase 4 Ibuprofen;Acetaminophen
32 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Active, not recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
33 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
34 Pharmacokinetics of Amlodipine Besylate at Delivery and During Lactation Active, not recruiting NCT02353806 Phase 4 Amlodipine besylate
35 Discontinuation of Magnesium Sulfate After Delivery in Women With Severe Preeclampsia. A Randomized Controlled Trial Not yet recruiting NCT03318211 Phase 4 Magnesium Sulfate
36 Effect of Administering Intravenous Magnesium Sulfate on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients Not yet recruiting NCT03237000 Phase 4 MgSO4
37 Failure Rate of GLyburide And Metformin Among Gestational Diabetics Not yet recruiting NCT03078725 Phase 4 Glyburide;Metformin
38 LMWH to Prevent Preeclampsia and Fetal Growth Restriction Terminated NCT00260520 Phase 4 Dalteparin
39 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
40 Comparison of Awakening Versus Bedtime Dosing of Aspirin in Pre-Hypertension or Mild Essential Hypertension Terminated NCT00449618 Phase 4 Aspirin 100 mg;Placebo
41 Atenativ Effect on Uterine Blood Flow and Preeclampsia Withdrawn NCT02278575 Phase 4 Atenativ
42 Low Dose Aspirin for the Prevention of Preeclampsia Unknown status NCT01890005 Phase 3 Aspirin;Placebo
43 PP13 and Doppler Study to Predict Preeclampsia Unknown status NCT00928213 Phase 2, Phase 3 Progesterone;Low molecular weight Heparin;No Drug
44 Investigating the Novel Observation of Right-Left Difference in Uterine Artery Vascular Resistance in Pre-Eclampsia Unknown status NCT00848679 Phase 3 Epidural lidocaine;Epidural lidocaine 2%
45 Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia Unknown status NCT01382732 Phase 3 Carbetocin;Oxytocin
46 Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine Unknown status NCT00409253 Phase 3 URAPIDIL (EUPRESSYL*);NICARDIPINE
47 Randomized Clinical Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients. Unknown status NCT02050529 Phase 2, Phase 3 Labetalol;Hydralazine
48 A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy Unknown status NCT02032186 Phase 3 Magnesium citrate
49 Effect of Micronutrients and Exercise During Pregnancy on Factors Related With Non-Transmissible Chronic Diseases Unknown status NCT00872365 Phase 2, Phase 3
50 Heparin for Pregnant Women With Thrombophilia Unknown status NCT01019655 Phase 3 Nadroparin calcium

Search NIH Clinical Center for Preeclampsia/eclampsia 1

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Preeclampsia/eclampsia 1

Genetic tests related to Preeclampsia/eclampsia 1:

# Genetic test Affiliating Genes
1 Preeclampsia/eclampsia 1 28 EPHX1 NOS3
2 Toxemia of Pregnancy 28

Anatomical Context for Preeclampsia/eclampsia 1

MalaCards organs/tissues related to Preeclampsia/eclampsia 1:

38
Liver, Endothelial, Testes, Placenta, Thyroid, Lung, Heart

Publications for Preeclampsia/eclampsia 1

Articles related to Preeclampsia/eclampsia 1:

# Title Authors Year
1
[Changes in serum lipoprotein (a) levels related to hyperlipidemia during pregnancy--comparing normal pregnancy and toxemia of pregnancy]. ( 8721051 )
1996
2
The relationship between clinical signs and hypercoagulable state in toxemia of pregnancy. ( 1828053 )
1991
3
[Blood coagulation and fibrinolytic studies in patients with toxemia of pregnancy]. ( 2273312 )
1990
4
Case report: ruptured spleen, placental abruption and toxemia of pregnancy. Simultaneous complications of pregnancy. ( 927413 )
1977
5
Alkaline phosphatase activity in dialysed urine samples from patients with normal pregnancy, toxemia of pregnancy and chronic pyelonephritis. ( 5720439 )
1968
6
CHORIOANGIOMA AND TOXEMIA OF PREGNANCY. ( 14258033 )
1965
7
Effect of intravenous procaine on anuria and oliguria associated with the toxemias of pregnancy. ( 13163491 )
1954
8
Retinal changes in the toxemias of pregnancy. I. History, vomiting of pregnancy, mild and severe pre-eclampsia, and eclampsia. ( 14885283 )
1951
9
Oliguria and anuria in toxemias of pregnancy. ( 18110648 )
1949

Variations for Preeclampsia/eclampsia 1

Expression for Preeclampsia/eclampsia 1

Search GEO for disease gene expression data for Preeclampsia/eclampsia 1.

Pathways for Preeclampsia/eclampsia 1

GO Terms for Preeclampsia/eclampsia 1

Sources for Preeclampsia/eclampsia 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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