MCID: PRC032
MIFTS: 18

Preeclampsia/eclampsia 2

Categories: Genetic diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Preeclampsia/eclampsia 2

MalaCards integrated aliases for Preeclampsia/eclampsia 2:

Name: Preeclampsia/eclampsia 2 54 13
Preeclampsia Eclampsia 2 69

Classifications:



External Ids:

OMIM 54 609402

Summaries for Preeclampsia/eclampsia 2

MalaCards based summary : Preeclampsia/eclampsia 2, is also known as preeclampsia eclampsia 2. An important gene associated with Preeclampsia/eclampsia 2 is PEE2 (Preeclampsia/Eclampsia 2). The drugs Methyldopa and Labetalol have been mentioned in the context of this disorder. Affiliated tissues include endothelial, testes and liver.

Description from OMIM: 609402

Related Diseases for Preeclampsia/eclampsia 2

Symptoms & Phenotypes for Preeclampsia/eclampsia 2

Clinical features from OMIM:

609402

Drugs & Therapeutics for Preeclampsia/eclampsia 2

Drugs for Preeclampsia/eclampsia 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 205)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4,Phase 2 555-30-6 38853
2
Labetalol Approved Phase 4,Phase 2,Phase 3 36894-69-6 3869
3
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 7487-88-9 24083
4
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
5
Ephedrine Approved Phase 4 299-42-3 9294
6
Oxymetazoline Approved Phase 4 1491-59-4 4636
7
Phenylephrine Approved Phase 4 59-42-7 6041
8
Pseudoephedrine Approved Phase 4 90-82-4 7028
9
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
10
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
11
Calcium Carbonate Approved Phase 4 471-34-1
12
Nifedipine Approved Phase 4 21829-25-4 4485
13 Adrenergic Agents Phase 4,Phase 3,Phase 2
14 Adrenergic Agonists Phase 4,Phase 2
15 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2
16 Adrenergic alpha-Agonists Phase 4,Phase 2
17 Antihypertensive Agents Phase 4,Phase 3,Phase 2
18 Autonomic Agents Phase 4,Phase 2,Phase 3
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Sympatholytics Phase 4,Phase 2
22 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
23 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1
24 calcium channel blockers Phase 4,Phase 3,Phase 2,Phase 1
25 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
26 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
27 Fibrinolytic Agents Phase 4,Phase 2,Phase 3
28 Bone Density Conservation Agents Phase 4,Phase 3,Phase 1,Phase 2
29 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3,Phase 2
30 Adrenergic alpha-Antagonists Phase 4,Phase 3,Phase 2
31 Adrenergic Antagonists Phase 4,Phase 3,Phase 2
32 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 3
33 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
35 Anticonvulsants Phase 4,Phase 2,Phase 3,Phase 1
36 Pharmaceutical Solutions Phase 4,Phase 3
37 Tocolytic Agents Phase 4,Phase 2,Phase 3,Phase 1
38 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3
39 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
40 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3
41 Antipyretics Phase 4,Phase 2,Phase 3
42 Antirheumatic Agents Phase 4,Phase 2,Phase 3
43 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3
44 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
45 Anti-Asthmatic Agents Phase 4
46 Bronchodilator Agents Phase 4
47 Central Nervous System Stimulants Phase 4
48 Mydriatics Phase 4
49 Nasal Decongestants Phase 4
50 Protective Agents Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 140)

id Name Status NCT ID Phase Drugs
1 Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia Unknown status NCT00117546 Phase 4 alpha methyldopa
2 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
3 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid;Acetylsalicylic Acid
4 Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Recruiting NCT03164304 Phase 4 Magnesium Sulfate
5 Phenylephrine Versus Ephedrine in Pre-eclampsia Recruiting NCT02025426 Phase 4 Phenylephrine;Ephedrine
6 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Recruiting NCT02891174 Phase 4 Ibuprofen;Acetaminophen
7 Low Dose Calcium to Prevent Preeclampsia Recruiting NCT02338687 Phase 4
8 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
9 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
10 Effect of Administering Intravenous Magnesium Sulfate on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients Not yet recruiting NCT03237000 Phase 4 MgSO4
11 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
12 Investigating the Novel Observation of Right-Left Difference in Uterine Artery Vascular Resistance in Pre-Eclampsia Unknown status NCT00848679 Phase 3 Epidural lidocaine;Epidural lidocaine 2%
13 Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine Unknown status NCT00409253 Phase 3 URAPIDIL (EUPRESSYL*);NICARDIPINE
14 PP13 and Doppler Study to Predict Preeclampsia Unknown status NCT00928213 Phase 2, Phase 3 Progesterone;Low molecular weight Heparin;No Drug
15 Randomized Clinical Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients. Unknown status NCT02050529 Phase 2, Phase 3 Labetalol;Hydralazine
16 Effect of Micronutrients and Exercise During Pregnancy on Factors Related With Non-Transmissible Chronic Diseases Unknown status NCT00872365 Phase 2, Phase 3
17 Nonsteroidal Antiinflammatory Drugs in Women With Postpartum Pre-eclampsia Completed NCT01988298 Phase 2, Phase 3 Ibuprofen;Acetaminophen
18 Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia Completed NCT02307201 Phase 2, Phase 3 Magnesium Sulfate
19 Induction With Foley OR Misoprostol (INFORM) Study Completed NCT01801410 Phase 3 Misoprostol
20 Combined Multi-marker Screening and Treatment With Aspirin for Pre-eclampsia Prevention Completed NCT02301780 Phase 3 Aspirin;Placebo
21 Magnesium Sulfate in Pregnancy and Postpartum Completed NCT02317146 Phase 2, Phase 3 Magnesium Sulfate
22 Calcium for Pre-Eclampsia Prevention (CPEP) Completed NCT00000534 Phase 3 calcium
23 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
24 Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion Completed NCT00959621 Phase 3 Aspirin;Klexane;Klexane and ASA
25 Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS) Completed NCT00135707 Phase 3
26 Antioxidant Supplementation in Pregnant Women Completed NCT01232205 Phase 2, Phase 3
27 Metformin in Pregnant PCOS Women Completed NCT00159536 Phase 3 Metformin;Placebo
28 Evaluation of the Efficacy of Citrulline Supplementation on the Delay of Delivery for Women Hospitalized for Pre-eclampsia (CITRUPE) Recruiting NCT02801695 Phase 2, Phase 3 Citrulline;Placebo
29 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia Recruiting NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
30 The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine Recruiting NCT02558023 Phase 3 Urapidil;Nicardipine
31 Post-preeclampsia Renal Project: Study of Nephroprotection in Women Having Suffered Preeclampsia Recruiting NCT01095939 Phase 3 Placebo;Benazepril hydrochloride
32 Esomeprazole in Treatment of Early Onset Preeclampsia (ESOPE Trial) Not yet recruiting NCT03213639 Phase 2, Phase 3 Esomeprazole 40 mg Oral Tablet;Placebo Oral Tablet
33 Efficacy of Sildenafil in Preterm Preeclampsia Not yet recruiting NCT02782559 Phase 2, Phase 3 Sildenafil;Placebo
34 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
35 Parturient Controlled Epidural Analgesia (PCEA) With or Without a Basal Infusion for Early Labor Withdrawn NCT00871442 Phase 3 PCEA solution (bupivacaine and fentanyl)
36 Rosuvastatin in Order to Induce Preeclampsia Resolution in Severe PET up to 48 Hours Following Delivery Unknown status NCT02314286 Phase 1, Phase 2 Rosuvastatin;Placebo
37 Prevention of Pre-Term Birth by Treatment of Periodontal Disease Unknown status NCT00133926 Phase 2
38 Physical Therapy in Pregnant Women With Preeclampsia Unknown status NCT01630772 Phase 1, Phase 2
39 Effect of Vitamin D3 Supplementation in Pregnancy on Risk of Pre-eclampsia Completed NCT03101150 Phase 1, Phase 2 400 IU Vitamin D3;4000 IU Vitamin D3
40 Laboratory and Pilot Clinical Assessment of the Accuracy, Usability, and Function of a Low-cost, Low-power Syringe Pump in Administering Magnesium Sulfate to Pre-eclamptic Women in a Low-resource Hospital Completed NCT02296931 Phase 1, Phase 2 Magnesium Sulfate
41 Dexmedetomidine vs. Remifentanil for Pre-eclampsia During Caesarean Delivery Completed NCT01766089 Phase 2 Remifentanil;Dexmedetomidine
42 Disease Modification in Toxaemia of Pregnancy Completed NCT00175695 Phase 2 Recombinant human activated protein C or drotrecogin alpha
43 Efficacy Study of Digibind for Treatment of Severe Preeclampsia Completed NCT00158743 Phase 2 Anti-digoxin antibody (FAB fragment)
44 Prevalence Study of Sleep Apnea in Women With Preeclampsia Completed NCT00259688 Phase 2
45 Left Ventricular and Endothelial Function in Preeclampsia Completed NCT00201500 Phase 1, Phase 2
46 Oral Calcium in Pregnant Women With Hypertension Completed NCT00000543 Phase 2 calcium
47 Effect of Methyldopa on Uterine Artery Diameter in Pregnant Women With Mild Preeclampsia Completed NCT01674127 Phase 2 Methyldopa;Placebo
48 Consumption of Chocolate in Pregnant Women. Completed NCT01431443 Phase 2
49 Antioxidant Supplementation in Pregnant Women With Low Antioxidant Status Completed NCT00388856 Phase 2 Vitamin C 1000mg and E 400IU
50 Influence of Physical Exercise on Endothelial Function in Pregnant Women Completed NCT00741312 Phase 1, Phase 2

Search NIH Clinical Center for Preeclampsia/eclampsia 2

Genetic Tests for Preeclampsia/eclampsia 2

Anatomical Context for Preeclampsia/eclampsia 2

MalaCards organs/tissues related to Preeclampsia/eclampsia 2:

39
Endothelial, Testes, Liver, Heart, Thyroid, Placenta, Ovary

Publications for Preeclampsia/eclampsia 2

Variations for Preeclampsia/eclampsia 2

Expression for Preeclampsia/eclampsia 2

Search GEO for disease gene expression data for Preeclampsia/eclampsia 2.

Pathways for Preeclampsia/eclampsia 2

GO Terms for Preeclampsia/eclampsia 2

Sources for Preeclampsia/eclampsia 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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