MCID: PRC033
MIFTS: 18

Preeclampsia/eclampsia 3

Categories: Genetic diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Preeclampsia/eclampsia 3

MalaCards integrated aliases for Preeclampsia/eclampsia 3:

Name: Preeclampsia/eclampsia 3 54 13
Preeclampsia Eclampsia 3 69

Classifications:



External Ids:

OMIM 54 609403

Summaries for Preeclampsia/eclampsia 3

MalaCards based summary : Preeclampsia/eclampsia 3, is also known as preeclampsia eclampsia 3. An important gene associated with Preeclampsia/eclampsia 3 is PEE3 (Preeclampsia/Eclampsia 3). The drugs Acetaminophen and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include endothelial, placenta and testes.

Description from OMIM: 609403

Related Diseases for Preeclampsia/eclampsia 3

Symptoms & Phenotypes for Preeclampsia/eclampsia 3

Clinical features from OMIM:

609403

Drugs & Therapeutics for Preeclampsia/eclampsia 3

Drugs for Preeclampsia/eclampsia 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 194)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
2
Ibuprofen Approved Phase 4,Phase 2,Phase 3 15687-27-1 3672
3
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 7487-88-9 24083
4
Desogestrel Approved Phase 4 54024-22-5 40973
5
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
6
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 67-97-0 6221 10883523 5280795
7
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 50-14-6 5280793
8
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 1406-16-2
9 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1
10 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1
11 Vitamins Phase 4,Phase 2,Phase 3,Phase 1
12 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
13 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
14 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
15 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
16 Antipyretics Phase 4,Phase 3,Phase 2
17 Antirheumatic Agents Phase 4,Phase 3,Phase 2
18 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
19 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Hormone Antagonists Phase 4,Phase 2,Phase 3
21 Hormones Phase 4,Phase 2,Phase 3
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
23 Progestins Phase 4,Phase 2,Phase 3
24 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
25 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1
26 calcium channel blockers Phase 4,Phase 3,Phase 2,Phase 1
27 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
28 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
29 Bone Density Conservation Agents Phase 4,Phase 3,Phase 1,Phase 2
30 Ergocalciferols Phase 4,Phase 1,Phase 2
31 Anticonvulsants Phase 4,Phase 3,Phase 2,Phase 1
32 Tocolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Contraceptive Agents Phase 4
34 Contraceptives, Oral Phase 4
35
Ethylene Phase 4 74-85-1 6325
36 Calciferol Nutraceutical Phase 4,Phase 1,Phase 2
37 Vitamin D2 Nutraceutical Phase 4,Phase 1,Phase 2
38
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
39
Nicardipine Approved Phase 3 55985-32-5 4474
40
Hydralazine Approved Phase 2, Phase 3 86-54-4 3637
41
Labetalol Approved Phase 2, Phase 3 36894-69-6 3869
42
Dalteparin Approved Phase 2, Phase 3 9005-49-6
43
Heparin Approved, Investigational Phase 2, Phase 3 9005-49-6 772 46507594
44
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
45
Carbetocin Approved Phase 3 37025-55-1 71715 16681432
46
Oxytocin Approved, Vet_approved Phase 3,Early Phase 1 50-56-6 439302 53477758
47
Aspirin Approved, Vet_approved Phase 3,Phase 2 50-78-2 2244
48 Magnesium citrate Approved Phase 3
49
Zinc Approved Phase 2, Phase 3 7440-66-6 32051 23994
50
Ephedrine Approved Phase 3 299-42-3 9294

Interventional clinical trials:

(show top 50) (show all 110)

id Name Status NCT ID Phase Drugs
1 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
2 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Recruiting NCT02891174 Phase 4 Ibuprofen;Acetaminophen
3 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
4 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
5 Effect of Administering Intravenous Magnesium Sulfate on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients Not yet recruiting NCT03237000 Phase 4 MgSO4
6 Investigating the Novel Observation of Right-Left Difference in Uterine Artery Vascular Resistance in Pre-Eclampsia Unknown status NCT00848679 Phase 3 Epidural lidocaine;Epidural lidocaine 2%
7 Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine Unknown status NCT00409253 Phase 3 URAPIDIL (EUPRESSYL*);NICARDIPINE
8 Randomized Clinical Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients. Unknown status NCT02050529 Phase 2, Phase 3 Labetalol;Hydralazine
9 PP13 and Doppler Study to Predict Preeclampsia Unknown status NCT00928213 Phase 2, Phase 3 Progesterone;Low molecular weight Heparin;No Drug
10 Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia Unknown status NCT01382732 Phase 3 Carbetocin;Oxytocin
11 Low Dose Aspirin for the Prevention of Preeclampsia Unknown status NCT01890005 Phase 3 Aspirin;Placebo
12 A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy Unknown status NCT02032186 Phase 3 Magnesium citrate
13 Effect of Micronutrients and Exercise During Pregnancy on Factors Related With Non-Transmissible Chronic Diseases Unknown status NCT00872365 Phase 2, Phase 3
14 Can Atorvastatin Improve Vascular Function in Women With a History of Preeclampsia? Completed NCT01278459 Phase 3 Atorvastatin
15 RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil Completed NCT00097110 Phase 3 Vitamin C and E
16 Nonsteroidal Antiinflammatory Drugs in Women With Postpartum Pre-eclampsia Completed NCT01988298 Phase 2, Phase 3 Ibuprofen;Acetaminophen
17 Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol Completed NCT02086994 Phase 3 misoprostol;carbetocin
18 New Magnesium Sulphate Protocol for Pre-eclampsia Completed NCT01846156 Phase 3 MgSO4
19 Antepartum Chronic Epidural Therapy (ACET) to Improve Blood Flow to the Uterus, Placenta and Baby in Pre-Eclampsia and Intrauterine Growth Restriction Completed NCT00197340 Phase 3 Epidural ropivacaine
20 Combined Multi-marker Screening and Treatment With Aspirin for Pre-eclampsia Prevention Completed NCT02301780 Phase 3 Aspirin;Placebo
21 L-Arginine in Pre-Eclampsia Completed NCT00157521 Phase 3 L-arginine
22 Magnesium Sulfate in Pregnancy and Postpartum Completed NCT02317146 Phase 2, Phase 3 Magnesium Sulfate
23 Induction With Foley OR Misoprostol (INFORM) Study Completed NCT01801410 Phase 3 Misoprostol
24 Calcium for Pre-Eclampsia Prevention (CPEP) Completed NCT00000534 Phase 3 calcium
25 Low Molecular Weight Heparin and/or Aspirin in Prevention of Habitual Abortion Completed NCT00959621 Phase 3 Aspirin;Klexane;Klexane and ASA
26 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
27 Magnesium Sulfate During the Postpartum in Women With Severe Preeclampsia Completed NCT02307201 Phase 2, Phase 3 Magnesium Sulfate
28 Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS) Completed NCT00135707 Phase 3
29 Efficacy and Safety of L Arginine to Prevent Preeclampsia Completed NCT02363348 Phase 3
30 Coenzyme Q10 Supplementation and Development of Preeclampsia Completed NCT00300937 Phase 3
31 Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia Completed NCT02059135 Phase 3
32 TIPPS: Thrombophilia in Pregnancy Prophylaxis Study Completed NCT00967382 Phase 3 dalteparin sodium
33 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo
34 Hydralazine Versus Labetalol for the Management of Hypertensive Disorders of Pregnancy Completed NCT01538875 Phase 3 Hydralazine;Labetalol
35 Antioxidant Supplementation in Pregnant Women Completed NCT01232205 Phase 2, Phase 3
36 Low Weight Heparin prOphylaxis for Placental‐Mediated Complications of PrEgnancy Completed NCT01388322 Phase 3 Enoxaparin
37 Evaluation of the Efficacy of Citrulline Supplementation on the Delay of Delivery for Women Hospitalized for Pre-eclampsia (CITRUPE) Recruiting NCT02801695 Phase 2, Phase 3 Citrulline;Placebo
38 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia Recruiting NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
39 Prevention of Preeclampsia With Aspirin in Recipients of Donated Oocytes. Recruiting NCT02174328 Phase 3 Acetylsalicylic acid;Placebo
40 The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine Recruiting NCT02558023 Phase 3 Urapidil;Nicardipine
41 Post-preeclampsia Renal Project: Study of Nephroprotection in Women Having Suffered Preeclampsia Recruiting NCT01095939 Phase 3 Placebo;Benazepril hydrochloride
42 Low Dose Aspirin in the Prevention of Preeclampsia in China Recruiting NCT02797249 Phase 3 Aspirin
43 Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe/Superimposed Preeclampsia Recruiting NCT02989025 Phase 3 17 OHPC
44 Magnesium Sulphate for Preterm Birth (MASP Study) Recruiting NCT01492608 Phase 3 Magnesium sulphate
45 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Recruiting NCT02336243 Phase 3
46 Esomeprazole in Treatment of Early Onset Preeclampsia (ESOPE Trial) Not yet recruiting NCT03213639 Phase 2, Phase 3 Esomeprazole 40 mg Oral Tablet;Placebo Oral Tablet
47 Prospects for the Prevention of Pregnancy-induced Hypertension and Preeclampsia Trial Not yet recruiting NCT02007837 Phase 3 Combined aspirin and multinutrient supplement
48 Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care Not yet recruiting NCT03237819 Phase 3 Sulfate, Magnesium;Placebo - Concentrate
49 Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide Not yet recruiting NCT03298802 Phase 3 Hydrochlorothiazide 50mg Tablet;Placebo oral capsule
50 Efficacy of Sildenafil in Preterm Preeclampsia Not yet recruiting NCT02782559 Phase 2, Phase 3 Sildenafil;Placebo

Search NIH Clinical Center for Preeclampsia/eclampsia 3

Genetic Tests for Preeclampsia/eclampsia 3

Anatomical Context for Preeclampsia/eclampsia 3

MalaCards organs/tissues related to Preeclampsia/eclampsia 3:

39
Endothelial, Placenta, Testes, Uterus, Ovary, Liver, Thyroid

Publications for Preeclampsia/eclampsia 3

Variations for Preeclampsia/eclampsia 3

Expression for Preeclampsia/eclampsia 3

Search GEO for disease gene expression data for Preeclampsia/eclampsia 3.

Pathways for Preeclampsia/eclampsia 3

GO Terms for Preeclampsia/eclampsia 3

Sources for Preeclampsia/eclampsia 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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