MCID: PRC034
MIFTS: 25

Preeclampsia/eclampsia 4

Categories: Genetic diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Preeclampsia/eclampsia 4

MalaCards integrated aliases for Preeclampsia/eclampsia 4:

Name: Preeclampsia/eclampsia 4 54 13
Gestational Proteinuric Hypertension 71
Pre-Eclampsia/eclampsia 4 71
Preeclampsia Eclampsia 4 69
Pee4 71

Characteristics:

HPO:

32
preeclampsia/eclampsia 4:
Inheritance polygenic inheritance


Classifications:



External Ids:

OMIM 54 609404
MedGen 40 C1836255
SNOMED-CT via HPO 65 15938005 15394000 398254007

Summaries for Preeclampsia/eclampsia 4

UniProtKB/Swiss-Prot : 71 Pre-eclampsia/eclampsia 4: A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide.

MalaCards based summary : Preeclampsia/eclampsia 4, also known as gestational proteinuric hypertension, is related to preeclampsia/eclampsia 1 and preeclampsia/eclampsia 5, and has symptoms including eclampsia and preeclampsia. An important gene associated with Preeclampsia/eclampsia 4 is STOX1 (Storkhead Box 1). The drugs Methyldopa and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and liver.

Description from OMIM: 609404

Related Diseases for Preeclampsia/eclampsia 4

Diseases in the Preeclampsia/eclampsia 1 family:

Preeclampsia/eclampsia 2 Preeclampsia/eclampsia 5
Preeclampsia/eclampsia 3 Preeclampsia/eclampsia 4

Diseases related to Preeclampsia/eclampsia 4 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 preeclampsia/eclampsia 1 11.8
2 preeclampsia/eclampsia 5 11.2
3 beckwith-wiedemann syndrome 9.9
4 pre-eclampsia 9.9
5 eclampsia 9.9

Graphical network of the top 20 diseases related to Preeclampsia/eclampsia 4:



Diseases related to Preeclampsia/eclampsia 4

Symptoms & Phenotypes for Preeclampsia/eclampsia 4

Clinical features from OMIM:

609404

Human phenotypes related to Preeclampsia/eclampsia 4:

32
id Description HPO Frequency HPO Source Accession
1 eclampsia 32 HP:0100601
2 preeclampsia 32 HP:0100602

Drugs & Therapeutics for Preeclampsia/eclampsia 4

Drugs for Preeclampsia/eclampsia 4 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 161)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4 555-30-6 38853
2
Remifentanil Approved Phase 4 132875-61-7 60815
3
Dalteparin Approved Phase 4,Phase 2,Phase 3 9005-49-6
4
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3 9005-49-6 772 46507594
5
Labetalol Approved Phase 4,Phase 2,Phase 3 36894-69-6 3869
6
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
7
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 7487-88-9 24083
8
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
9
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
10
Levobupivacaine Approved Phase 4 27262-47-1 92253
11
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
12
Captopril Approved Phase 4 62571-86-2 44093
13
Clonidine Approved Phase 4 4205-90-7 2803
14
Calcium Carbonate Approved Phase 4 471-34-1
15
Ephedrine Approved Phase 4 299-42-3 9294
16
Oxymetazoline Approved Phase 4 1491-59-4 4636
17
Phenylephrine Approved Phase 4 59-42-7 6041
18
Pseudoephedrine Approved Phase 4 90-82-4 7028
19
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
20
Acetaminophen Approved Phase 4 103-90-2 1983
21
Ibuprofen Approved Phase 4 15687-27-1 3672
22
Nifedipine Approved Phase 4 21829-25-4 4485
23
Benzocaine Approved Phase 4,Phase 3 1994-09-7, 94-09-7 2337
24
Desogestrel Approved Phase 4 54024-22-5 40973
25
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
26
Thrombin Approved Phase 4
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
28
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 143 6006
29
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
30
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
31
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
32 tannic acid Approved, Nutraceutical Phase 4,Phase 3
33 Antihypertensive Agents Phase 4,Phase 3,Phase 2
34 Adrenergic Agents Phase 4,Phase 3,Phase 2
35 Adrenergic Agonists Phase 4
36 Adrenergic alpha-2 Receptor Agonists Phase 4
37 Adrenergic alpha-Agonists Phase 4
38 Autonomic Agents Phase 4,Phase 2,Phase 3
39 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
40 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Sympatholytics Phase 4
42 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
43 Analgesics, Opioid Phase 4
44 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
45 Anesthetics, General Phase 4
46 Anesthetics, Intravenous Phase 4
47 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
48 Hypnotics and Sedatives Phase 4
49 Narcotics Phase 4
50 Fibrinolytic Agents Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 89)

id Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia Unknown status NCT00117546 Phase 4 alpha methyldopa
3 Remifentanil for General Anesthesia in Preeclamptics Unknown status NCT00567957 Phase 4 Remifentanil;Saline
4 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
5 Effects of Magnesium Sulphate on Sugammadex Reversal of Rocuronium Induced Blockade in Gynaecology Patients Completed NCT01972659 Phase 4 placebo;Magnesium Sulphate;sugammadex
6 Effectiveness Study of Short Course of Magnesium Sulfate for Severe Preeclamsia Completed NCT01408979 Phase 4 Magnesium sulfate 12 hours;Magnesium sulfate 24 hours
7 Treatment Approaches to Preeclampsia Completed NCT01030627 Phase 4
8 Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
9 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
10 Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia Completed NCT01352234 Phase 4 Acetylsalicylic Acid;Acetylsalicylic Acid
11 A Study of Cerebral-circulatory Response to Intravenous Antihypertensive Treatment in Women With Serious Preeclampsia Completed NCT00403572 Phase 4
12 Hemodynamic Measurements in Women With Serious Preeclampsia Completed NCT00199810 Phase 4
13 A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen Completed NCT02091401 Phase 4 Magnesium Sulfate
14 Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure Completed NCT01761916 Phase 4 CLONIDINE;CAPTOPRIL
15 Low Molecular Weight Heparin in Recurrent Miscarriage With Negative Antiphospholipid Antibodies Completed NCT01608347 Phase 4 LMWH+Folic acid;Folic Acid
16 Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Recruiting NCT03164304 Phase 4 Magnesium Sulfate
17 Phenylephrine Versus Ephedrine in Pre-eclampsia Recruiting NCT02025426 Phase 4 Phenylephrine;Ephedrine
18 Impact of Antichlamydial Treatment on the Rate of Preeclampsia Recruiting NCT03233880 Phase 4 Azithromycin 1gm
19 The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy Recruiting NCT02891174 Phase 4 Ibuprofen;Acetaminophen
20 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
21 Low Dose Calcium to Prevent Preeclampsia Recruiting NCT02338687 Phase 4
22 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
23 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
24 Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy Recruiting NCT01912677 Phase 4 Nifedipine;Labetalol;Methyldopa
25 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
26 Effect of Administering Intravenous Magnesium Sulfate on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients Not yet recruiting NCT03237000 Phase 4 MgSO4
27 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
28 LMWH to Prevent Preeclampsia and Fetal Growth Restriction Terminated NCT00260520 Phase 4 Dalteparin
29 Atenativ Effect on Uterine Blood Flow and Preeclampsia Withdrawn NCT02278575 Phase 4 Atenativ
30 Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine Unknown status NCT00409253 Phase 3 URAPIDIL (EUPRESSYL*);NICARDIPINE
31 Carbetocin vs. Oxytocin for Prevention of Postpartum Bleeding in Patients With Severe Preeclampsia Unknown status NCT01382732 Phase 3 Carbetocin;Oxytocin
32 PP13 and Doppler Study to Predict Preeclampsia Unknown status NCT00928213 Phase 2, Phase 3 Progesterone;Low molecular weight Heparin;No Drug
33 Randomized Clinical Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients. Unknown status NCT02050529 Phase 2, Phase 3 Labetalol;Hydralazine
34 New Magnesium Sulphate Protocol for Pre-eclampsia Completed NCT01846156 Phase 3 MgSO4
35 Magnesium Sulfate in Pregnancy and Postpartum Completed NCT02317146 Phase 2, Phase 3 Magnesium Sulfate
36 Can Atorvastatin Improve Vascular Function in Women With a History of Preeclampsia? Completed NCT01278459 Phase 3 Atorvastatin
37 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3 Folic Acid 4 mg;Placebo
38 Induction With Foley OR Misoprostol (INFORM) Study Completed NCT01801410 Phase 3 Misoprostol
39 Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia Completed NCT02059135 Phase 3
40 Coenzyme Q10 Supplementation and Development of Preeclampsia Completed NCT00300937 Phase 3
41 The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine Recruiting NCT02558023 Phase 3 Urapidil;Nicardipine
42 Prospects for the Prevention of Pregnancy-induced Hypertension and Preeclampsia Trial Not yet recruiting NCT02007837 Phase 3 Combined aspirin and multinutrient supplement
43 Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care Not yet recruiting NCT03237819 Phase 3 Sulfate, Magnesium;Placebo - Concentrate
44 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
45 Laboratory and Pilot Clinical Assessment of the Accuracy, Usability, and Function of a Low-cost, Low-power Syringe Pump in Administering Magnesium Sulfate to Pre-eclamptic Women in a Low-resource Hospital Completed NCT02296931 Phase 1, Phase 2 Magnesium Sulfate
46 Efficacy Study of Digibind for Treatment of Severe Preeclampsia Completed NCT00158743 Phase 2 Anti-digoxin antibody (FAB fragment)
47 Study of the Efficacy and Safety of DigiFab® in Antepartum Subjects With Severe Preeclampsia Recruiting NCT03008616 Phase 2
48 Magnesium Sulfate in Obese Preeclamptics Enrolling by invitation NCT02835339 Phase 1, Phase 2 Magnesium sulfate 4g loading dose, 1g/hr infusion;Magnesium sulfate 6g loading dose, 2g/hr infusion
49 Pre-eclampsia and Metabolomics Unknown status NCT00939575
50 Predicitve Use of Spot Urine Protein/Creatinine Ratios in Preeclampsia Unknown status NCT00870428

Search NIH Clinical Center for Preeclampsia/eclampsia 4

Genetic Tests for Preeclampsia/eclampsia 4

Anatomical Context for Preeclampsia/eclampsia 4

MalaCards organs/tissues related to Preeclampsia/eclampsia 4:

39
Heart, Testes, Liver, Bone

Publications for Preeclampsia/eclampsia 4

Variations for Preeclampsia/eclampsia 4

UniProtKB/Swiss-Prot genetic disease variations for Preeclampsia/eclampsia 4:

71
id Symbol AA change Variation ID SNP ID
1 STOX1 p.Arg18Pro VAR_023784 rs556362193
2 STOX1 p.Asn825Ile VAR_023787 rs41278532

ClinVar genetic disease variations for Preeclampsia/eclampsia 4:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 STOX1 NM_001130161.2(STOX1): c.457T> C (p.Tyr153His) single nucleotide variant risk factor rs1341667 GRCh37 Chromosome 10, 70641860: 70641860
2 STOX1 NM_001130161.2(STOX1): c.1824A> C (p.Glu608Asp) single nucleotide variant Pathogenic rs10509305 GRCh37 Chromosome 10, 70645376: 70645376

Expression for Preeclampsia/eclampsia 4

Search GEO for disease gene expression data for Preeclampsia/eclampsia 4.

Pathways for Preeclampsia/eclampsia 4

GO Terms for Preeclampsia/eclampsia 4

Sources for Preeclampsia/eclampsia 4

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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