MCID: PRC045
MIFTS: 28

Preeclampsia/eclampsia 5

Categories: Genetic diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Preeclampsia/eclampsia 5

MalaCards integrated aliases for Preeclampsia/eclampsia 5:

Name: Preeclampsia/eclampsia 5 54 24 29 13 69
Gestational Proteinuric Hypertension 71
Pre-Eclampsia/eclampsia 5 71
Corin 24
Pee5 71

Characteristics:

HPO:

32
preeclampsia/eclampsia 5:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 54 614595
MedGen 40 C3281288

Summaries for Preeclampsia/eclampsia 5

UniProtKB/Swiss-Prot : 71 Pre-eclampsia/eclampsia 5: A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide.

MalaCards based summary : Preeclampsia/eclampsia 5, also known as gestational proteinuric hypertension, is related to systolic heart failure and pre-eclampsia, and has symptoms including preeclampsia and eclampsia. An important gene associated with Preeclampsia/eclampsia 5 is CORIN (Corin, Serine Peptidase). The drugs Methyldopa and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, testes and liver.

Description from OMIM: 614595

Related Diseases for Preeclampsia/eclampsia 5

Diseases in the Preeclampsia/eclampsia 1 family:

Preeclampsia/eclampsia 2 Preeclampsia/eclampsia 5
Preeclampsia/eclampsia 3 Preeclampsia/eclampsia 4

Diseases related to Preeclampsia/eclampsia 5 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
id Related Disease Score Top Affiliating Genes
1 systolic heart failure 11.3
2 pre-eclampsia 11.0
3 eclampsia 11.0
4 deafness, autosomal recessive 25 10.9
5 deafness, autosomal recessive 24 10.9
6 total anomalous pulmonary venous return 1 10.9
7 preeclampsia/eclampsia 1 10.7
8 kidney disease 9.9
9 myocardial infarction 9.9
10 cardiomyopathy 9.7
11 lung cancer 9.7
12 osteoporosis 9.7
13 acute myocardial infarction 9.7
14 dilated cardiomyopathy 9.7
15 atrial fibrillation 9.7

Graphical network of the top 20 diseases related to Preeclampsia/eclampsia 5:



Diseases related to Preeclampsia/eclampsia 5

Symptoms & Phenotypes for Preeclampsia/eclampsia 5

Clinical features from OMIM:

614595

Human phenotypes related to Preeclampsia/eclampsia 5:

32
id Description HPO Frequency HPO Source Accession
1 preeclampsia 32 HP:0100602
2 eclampsia 32 HP:0100601

Drugs & Therapeutics for Preeclampsia/eclampsia 5

Drugs for Preeclampsia/eclampsia 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyldopa Approved Phase 4 555-30-6 38853
2
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
3
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
4
Bupivacaine Approved, Investigational Phase 4,Phase 3 2180-92-9, 38396-39-3 2474
5
Levobupivacaine Approved Phase 4 27262-47-1 92253
6
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 3 7487-88-9 24083
7 Antihypertensive Agents Phase 4,Phase 3,Phase 2
8 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
9 Anesthetics Phase 4,Phase 3,Phase 2
10 Anesthetics, Local Phase 4,Phase 3
11 Anti-Arrhythmia Agents Phase 4,Phase 3
12 calcium channel blockers Phase 4,Phase 3
13 Calcium, Dietary Phase 4,Phase 3,Phase 2
14 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
15 Analgesics Phase 4,Phase 3,Phase 2
16 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
17 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
18 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
19 Antipyretics Phase 4,Phase 3,Phase 2
20 Antirheumatic Agents Phase 4,Phase 3,Phase 2
21 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
22 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
23 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
24 diuretics Phase 4,Phase 2
25 Natriuretic Agents Phase 4,Phase 2
26 Sodium Potassium Chloride Symporter Inhibitors Phase 4,Phase 2
27 Anticonvulsants Phase 4,Phase 3
28 Tocolytic Agents Phase 4,Phase 3
29
Nicardipine Approved Phase 3 55985-32-5 4474
30
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
31
Hydralazine Approved Phase 2, Phase 3 86-54-4 3637
32
Labetalol Approved Phase 2, Phase 3 36894-69-6 3869
33
Ephedrine Approved Phase 3 299-42-3 9294
34
Metaraminol Approved, Investigational Phase 3 54-49-9 5906
35
Pseudoephedrine Approved Phase 3 90-82-4 7028
36
Magnesium oxide Approved Phase 3 1309-48-4 14792
37
Nitric Oxide Approved Phase 3 10102-43-9 145068
38
Dalteparin Approved Phase 3 9005-49-6
39
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
40
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
41
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
42
Hydroxocobalamin Approved Phase 3 13422-51-0 11953898 5460373 44475014
43
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1 59-30-3 6037
44
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
45 tannic acid Approved, Nutraceutical Phase 3
46
Cyanocobalamin Approved, Nutraceutical Phase 3 68-19-9 44176380
47
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
48 Urapidil Investigational Phase 3 34661-75-1
49 Adrenergic Agents Phase 3,Phase 2
50 Adrenergic alpha-1 Receptor Antagonists Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 63)

id Name Status NCT ID Phase Drugs
1 Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) Unknown status NCT01361425 Phase 4 methildopa;placebo
2 Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers Completed NCT01729468 Phase 4 Aspirin;Placebo
3 Diuretics for Postpartum High Blood Pressure in Preeclampsia Completed NCT02163655 Phase 4 FUROSEMIDE;Placebo
4 Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia Completed NCT02699827 Phase 4 Levobupivacaine hydrochloride;Magnesium sulphate;Saline 0.9%
5 Treatment of Severe Hypertension During Pre-Eclampsia: A Preliminary Equivalence Study Between Urapidil and Nicardipine Unknown status NCT00409253 Phase 3 URAPIDIL (EUPRESSYL*);NICARDIPINE
6 Investigating the Novel Observation of Right-Left Difference in Uterine Artery Vascular Resistance in Pre-Eclampsia Unknown status NCT00848679 Phase 3 Epidural lidocaine;Epidural lidocaine 2%
7 Randomized Clinical Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients. Unknown status NCT02050529 Phase 2, Phase 3 Labetalol;Hydralazine
8 Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia Completed NCT02059135 Phase 3
9 Efficacy and Safety of L Arginine to Prevent Preeclampsia Completed NCT02363348 Phase 3
10 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
11 Hydralazine Versus Labetalol for the Management of Hypertensive Disorders of Pregnancy Completed NCT01538875 Phase 3 Hydralazine;Labetalol
12 Prevention of Preeclampsia With Aspirin in Recipients of Donated Oocytes. Recruiting NCT02174328 Phase 3 Acetylsalicylic acid;Placebo
13 The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine Recruiting NCT02558023 Phase 3 Urapidil;Nicardipine
14 Use of Sildenafil Citrate in Management of Mild Pre-eclampsia Recruiting NCT03262961 Phase 2, Phase 3 Sildenafil 20 MG;Placebo Oral Tablet
15 Magnesium Sulphate for Preterm Birth (MASP Study) Recruiting NCT01492608 Phase 3 Magnesium sulphate
16 Prospects for the Prevention of Pregnancy-induced Hypertension and Preeclampsia Trial Not yet recruiting NCT02007837 Phase 3 Combined aspirin and multinutrient supplement
17 Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care Not yet recruiting NCT03237819 Phase 3 Sulfate, Magnesium;Placebo - Concentrate
18 Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean Withdrawn NCT01451060 Phase 3 Metaraminol;Ephedrine
19 Parturient Controlled Epidural Analgesia (PCEA) With or Without a Basal Infusion for Early Labor Withdrawn NCT00871442 Phase 3 PCEA solution (bupivacaine and fentanyl)
20 Dexmedetomidine vs. Remifentanil for Pre-eclampsia During Caesarean Delivery Completed NCT01766089 Phase 2 Remifentanil;Dexmedetomidine
21 Influence of Physical Exercise on Endothelial Function in Pregnant Women Completed NCT00741312 Phase 1, Phase 2
22 ToRsemide for pOstpartum HYpertension Recruiting NCT02813551 Phase 2 Torsemide;Placebo
23 The Effects of Lymphocyte Therapy on Pregnancy Rate of Patient With Recurrent Implantation Failure Recruiting NCT03267797 Phase 2 lymphocytes
24 Sildenafil Citrate for the Management of Asymmetrical Intrauterine Growth Restriction Not yet recruiting NCT02678221 Phase 2 Sildenafil citrate;Aspirin
25 Usefulness of Extracorporeal Removal of sFLT-1 in Women With Very Early Severe Preeclampsia Terminated NCT02286284 Phase 2
26 Sildenafil Citrate for the Treatment of Established Pre-Eclampsia Terminated NCT00141310 Phase 2 Sildenafil citrate
27 Nicotinamide Safety Study Completed NCT02213094 Phase 1 Nicotinamide
28 Pre-eclampsia and Metabolomics Unknown status NCT00939575
29 Ephedrine, Phenylephrine and Metaraminol Effects on Maternal Cardiac Output, Uterine Blood Flow and Fetal Circulation Unknown status NCT02245191 Ephedrine;Phenylephrine;Metaraminol
30 İs There a Relationship Between Severity of Preeclampsia and Maternal Heavy Metal Levels? Unknown status NCT01906567
31 PLAC1 in Reproduction Unknown status NCT01277848
32 Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity Unknown status NCT00573118
33 Effect of Psycho-education on Gestational Weight Gain and Anxiety/Depression in Obese Pregnant Women Unknown status NCT01329835
34 Mild Preeclampsia Near Term: Deliver or Deliberate? Completed NCT00789919
35 Study to Determine if Serum BNP Levels Are Elevated in Pregnant Women With Pre-Eclampsia Completed NCT00533871
36 Treatment Approaches for Preeclampsia in Low-Resource Settings Completed NCT00666133
37 A Modernized Approach to Prenatal Care in Low Risk Women Completed NCT01606774
38 Increased Salt Sensitivity of Ambulatory Blood Pressure in Women With a History of Severe Preeclampsia Completed NCT01874990
39 ST- Depression on Electrocardiogram During Caesarean Section in Regional Anaesthesia in Women With Preeclampsia Completed NCT01530230 oxytocin
40 Evaluation of Educational Tools for Pregnant Women Completed NCT01858324
41 Hypertension and Urine Protease Activity in Preeclampsia Completed NCT01828138
42 First Trimester Prediction of Preeclampsia and Fetal Growth Restriction Completed NCT02379494
43 Phenylephrine in Spinal Anesthesia in Preeclamptic Patients Completed NCT00458003 Ephedrine;Phenylephrine
44 Vitamin D and Pregnancy: Camden Study Completed NCT02032459
45 Effect of Magnesium Sulphate Pre-exposure on Oxytocin-induced Contractility in Desensitized Human Myometrium - an in Vitro Study Completed NCT02647268 Oxytocin;Magnesium Sulphate
46 Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana Completed NCT02468310
47 Combined Colloids And Crystalloids Versus Crystalloids in Women With Preeclampsia Undergoing Cesarean Delivery Recruiting NCT03252496 Intrathecal Bupivacaine;Intrathecal Fentanyl;250 mL Colloid over 5 minutes;250 mL Crystalloid over 5 minutes;500 mL Crystalloid over 55 minutes;250 mL Colloid over 60 minutes;250 mL Crystalloid over 60 minutes;Intravenous Ephedrine;Intravenous Syntocinon
48 Vascular Changes in Pre-Eclamptic Patients and Its Impact on Pregnancy Outcome. Recruiting NCT03111576
49 Heart Failure and Related Risk-factors After Preeclampsia Recruiting NCT02347540
50 Microcirculatory and Tissue and Cerebral Oxygenation in Preeclampsia and Normal Pregnancy: An Observation Study Recruiting NCT02351583

Search NIH Clinical Center for Preeclampsia/eclampsia 5

Genetic Tests for Preeclampsia/eclampsia 5

Genetic tests related to Preeclampsia/eclampsia 5:

id Genetic test Affiliating Genes
1 Preeclampsia/eclampsia 5 29 24

Anatomical Context for Preeclampsia/eclampsia 5

MalaCards organs/tissues related to Preeclampsia/eclampsia 5:

39
Endothelial, Testes, Liver, Bone, Heart

Publications for Preeclampsia/eclampsia 5

Variations for Preeclampsia/eclampsia 5

UniProtKB/Swiss-Prot genetic disease variations for Preeclampsia/eclampsia 5:

71
id Symbol AA change Variation ID SNP ID
1 CORIN p.Lys317Glu VAR_067795 rs387906894
2 CORIN p.Ser472Gly VAR_067797 rs387906895

ClinVar genetic disease variations for Preeclampsia/eclampsia 5:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 CORIN NM_006587.3(CORIN): c.949A> G (p.Lys317Glu) single nucleotide variant Pathogenic rs387906894 GRCh37 Chromosome 4, 47685820: 47685820
2 CORIN NM_006587.3(CORIN): c.1414A> G (p.Ser472Gly) single nucleotide variant Pathogenic rs387906895 GRCh37 Chromosome 4, 47667224: 47667224

Expression for Preeclampsia/eclampsia 5

Search GEO for disease gene expression data for Preeclampsia/eclampsia 5.

Pathways for Preeclampsia/eclampsia 5

GO Terms for Preeclampsia/eclampsia 5

Sources for Preeclampsia/eclampsia 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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