Aliases & Classifications for Premature Ejaculation

Summaries for Premature Ejaculation

MalaCards based summary : Premature Ejaculation is related to uterus intravascular leiomyomatosis and anosognosia, and has symptoms including decreased libido An important gene associated with Premature Ejaculation is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Taste transduction. The drugs Tadalafil and Phosphodiesterase 5 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and testes, and related phenotypes are Decreased viability and behavior/neurological

Wikipedia : 72 Premature ejaculation (PE) occurs when a man experiences orgasm and expels semen soon after sexual... more...

Related Diseases for Premature Ejaculation

Diseases related to Premature Ejaculation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
id Related Disease Score Top Affiliating Genes
1 uterus intravascular leiomyomatosis 10.5 HTR1A SLC6A4
2 anosognosia 10.5 HTR1A SLC6A4
3 luxation of globe 10.5 HTR1A SLC6A4
4 angiokeratoma of mibelli 10.5 HTR1A SLC6A4
5 chronic dacryoadenitis 10.4 HTR1A SLC6A4
6 intracranial cavernous angioma 10.4 SLC6A3 SLC6A4
7 splenic abscess 10.4 SLC6A3 SLC6A4
8 pyromania 10.4 SLC6A3 SLC6A4
9 hemorrhagic cystitis 10.3 SLC6A3 SLC6A4
10 pelvic inflammatory disease 10.3 HTR2C SLC6A4
11 prostatitis 10.3
12 munchausen by proxy 10.3 HTR1A PDE5A
13 tongue disease 10.3 SLC6A3 SLC6A4
14 hypoglycemic coma 10.3 HTR1A SLC6A4
15 tubular variant testicular seminoma 10.2 HTR1B SLC6A3
16 anxiety disorder 10.2 LEP SLC6A4
17 acute female pelvic peritonitis 10.2 SLC6A3 SLC6A4
18 pompholyx 10.2 HTR1A HTR2C SLC6A4
19 carotid stenosis 10.2 SLC6A3 SLC6A4
20 primary angle-closure glaucoma 10.2 HTR1A HTR2C SLC6A4
21 keratosis 10.2 HTR1A HTR2C SLC6A4
22 laryngeal adductor paralysis 10.2 HTR1A HTR2C SLC6A4
23 ornithosis 10.1 HTR3A SLC6A4
24 proteus syndrome, somatic 10.1 HTR1A SLC6A3
25 abnormal pupillary function 10.1 HTR1A HTR3A
26 tinea pedis 10.1 HTR1A SLC6A3 SLC6A4
27 bladder flat intraepithelial lesion 10.0 HTR1A SLC6A4
28 hyperimmunoglobulin syndrome 10.0 HTR1A HTR3A
29 bone fracture 10.0 HTR1A SLC6A3 SLC6A4
30 pervasive developmental disorder 10.0 SLC6A3 SLC6A4
31 colon mucinous adenocarcinoma 10.0 HTR1B SLC6A3 SLC6A4
32 infertility 9.9
33 hypogonadotropism 9.9
34 hyperthyroidism 9.9
35 mucositis 9.9
36 hypogonadotropic hypogonadism 9.9
37 hypogonadism 9.9
38 vaginitis 9.9
39 heroin dependence 9.9 HTR1B SLC6A3 SLC6A4
40 pauci-immune glomerulonephritis with anca 9.9 HTR3A SLC6A4
41 transsexualism 9.9 HTR1A HTR3A
42 scleral staphyloma 9.9 HTR3A PDE5A
43 social phobia 9.9
44 impotence 9.9
45 obesity 9.9
46 parkinson disease, late-onset 9.9 HTR1A SLC6A3 SLC6A4
47 vallecula cancer 9.8 HTR1A SLC6A4
48 lubani-al saleh-teebi syndrome 9.8 HTR1B PDE5A SLC6A4
49 myositis fibrosa 9.8 HTR3A SLC6A4
50 acquired aneurysmal subarachnoid hemorrhage 9.7 HTR1A HTR3A SLC6A4

Graphical network of the top 20 diseases related to Premature Ejaculation:



Diseases related to Premature Ejaculation

Symptoms & Phenotypes for Premature Ejaculation

UMLS symptoms related to Premature Ejaculation:


decreased libido

GenomeRNAi Phenotypes related to Premature Ejaculation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.1 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Premature Ejaculation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 HTR1A HTR1B HTR2C HTR3A LEP SLC6A3
2 mortality/aging MP:0010768 9.7 HTR1A HTR1B HTR2C HTR3A LEP SLC6A3
3 integument MP:0010771 9.65 HTR2C HTR3A LEP SLC6A3 SLC6A4
4 muscle MP:0005369 9.43 HTR1B HTR2C HTR3A LEP SLC6A3 SLC6A4
5 nervous system MP:0003631 9.1 HTR1A HTR2C HTR3A LEP SLC6A3 SLC6A4

Drugs & Therapeutics for Premature Ejaculation

Drugs for Premature Ejaculation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tadalafil Approved, Investigational Phase 4,Phase 3 171596-29-5 110635
2 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
3 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
4 Sildenafil Citrate Phase 4,Phase 3,Phase 2,Phase 1 171599-83-0
5 Vasodilator Agents Phase 4,Phase 2,Phase 1
6 Citrate Nutraceutical Phase 4,Phase 2,Phase 1
7
Citric Acid Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 77-92-9 311
8
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Phase 1 137-58-6 3676
9
Prilocaine Approved Phase 2, Phase 3,Phase 1 721-50-6 4906
10
Paroxetine Approved, Investigational Phase 3 61869-08-7 43815
11
Clomipramine Approved, Vet_approved Phase 3,Phase 2,Phase 1 303-49-1 2801
12
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
13
Norflurane Investigational Phase 2, Phase 3 811-97-2
14 Anesthetics Phase 3,Phase 2,Phase 1
15 Anesthetics, Local Phase 3,Phase 2,Phase 1
16 Anti-Arrhythmia Agents Phase 3,Phase 2
17 Central Nervous System Depressants Phase 3,Phase 2,Phase 1
18 Diuretics, Potassium Sparing Phase 3,Phase 2
19 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Early Phase 1
20 Sodium Channel Blockers Phase 3,Phase 2
21 Antidepressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
22 Antidepressive Agents, Second-Generation Phase 3,Early Phase 1
23 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Early Phase 1
24 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
25 Psychotropic Drugs Phase 3,Phase 2,Phase 1,Early Phase 1
26
Serotonin Phase 3,Phase 2,Phase 1,Early Phase 1 50-67-9 5202
27 Serotonin Agents Phase 3,Phase 2,Phase 1,Early Phase 1
28 Serotonin Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
29 EMLA Phase 2, Phase 3,Phase 1
30 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
31 Cytochrome P-450 Enzyme Inhibitors Phase 3
32 Antidepressive Agents, Tricyclic Phase 3,Phase 2,Phase 1
33 Vardenafil Dihydrochloride Phase 3
34 Analgesics Phase 3
35 Analgesics, Opioid Phase 3
36 Narcotics Phase 3
37
Silodosin Approved Phase 2 160970-54-7
38
Acetylcholine Approved Phase 2 51-84-3 187
39 Cholinergic Agents Phase 2,Early Phase 1
40 Anti-Bacterial Agents Phase 2,Phase 1
41 Anti-Infective Agents Phase 2,Phase 1
42 Diketopiperazines Phase 2,Phase 1
43 Adrenergic Agents Phase 2,Phase 1
44 Adrenergic alpha-1 Receptor Antagonists Phase 2,Phase 1
45 Adrenergic alpha-Antagonists Phase 2,Phase 1
46 Adrenergic Antagonists Phase 2,Phase 1
47 abobotulinumtoxinA Phase 2
48 Botulinum Toxins Phase 2
49 Botulinum Toxins, Type A Phase 2
50 Neuromuscular Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 58)

id Name Status NCT ID Phase Drugs
1 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Completed NCT02939495 Phase 4 Dapoxetine/Sildenafil 30/50 mg film coated tablet
2 An Observational Study of Men With Premature Ejaculation Who Are Treated With Dapoxetine Hydrochloride or Alternate Care Defined as Any Treatment Other Than Dapoxetine Hydrochloride Completed NCT01021670 Phase 4 Dapoxetine hydrochloride
3 PRILIGY Usage Patterns in Selected Populations Completed NCT01273545 Phase 4 PRILIGY (dapoxetine hydrochloride)
4 The Safety of Dapoxetine/Tadalafil Combination Therapy Active, not recruiting NCT03177746 Phase 4 Dapoxetine/Tadalafil 30/20 mg film coated tablet
5 Efficacy of Promescent Lidocaine Spray in Men With Premature Ejaculation Unknown status NCT02241460 Phase 3 Placebo;Promescent Lidocaine Spray
6 Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation Completed NCT00556478 Phase 2, Phase 3 PSD502, contains a mixture of lidocaine and prilocaine;Placebo
7 Efficacy and Safety of Paroxetine Daily Doses of 15 mg and 20 mg in the Treatment of Premature Ejaculation Completed NCT01024491 Phase 3 paroxetine;paroxetine;placebo
8 Trial of PED-1 in Male Patients With Premature Ejaculation Completed NCT01439984 Phase 3 Clomipramine
9 A Study to Evaluate Intravaginal Ejaculation Time in Men With and Without Premature Ejaculation Completed NCT00210678 Phase 3
10 The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy Completed NCT01063881 Phase 3 Dapoxetine
11 A Study of Withdrawal Effects With Dapoxetine in the Treatment of Premature Ejaculation Completed NCT00210613 Phase 3 Dapoxetine
12 Assessment of Efficacy and Safety of UK-390,957 in Men With Premature Ejaculation Completed NCT00143117 Phase 2, Phase 3 UK-390,957
13 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00210704 Phase 3 Dapoxetine
14 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00229073 Phase 3 dapoxetine
15 Assessment Of Efficacy and Safety UK-390,957 In Men With Premature Ejaculation Completed NCT00219635 Phase 2, Phase 3 UK-390,957
16 Assessment Of Efficacy and Safety Of UK-390,957 In Men With Premature Ejaculation Completed NCT00219583 Phase 2, Phase 3 UK-390,957
17 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00211094 Phase 3 Dapoxetine
18 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation. Completed NCT00211107 Phase 3 Dapoxetine
19 Concomitant Use of PriLigy in Men Treated for Erectile Dysfunction Completed NCT01063855 Phase 3 Placebo;Dapoxetine;PDE5I (phosphodiesterase-5 inhibitor)
20 Assessment Of Safety Of UK-390,957 Completed NCT00219609 Phase 2, Phase 3 UK-390,957
21 An Open-Label Study of the Long-Term Safety of Dapoxetine HCl in the Treatment of Rapid Ejaculation Completed NCT01230762 Phase 3 dapoxetine
22 Study to Evaluate Efficacy and Safety in Male Subjects With Premature Ejaculation Terminated NCT00983736 Phase 3 Tramadol Hydrochloride;Placebo
23 Study to Evaluate Efficacy and Safety in Males Subjects With Premature Ejaculation Terminated NCT00983151 Phase 3 Tramadol Hydrochloride & Placebo
24 Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation Unknown status NCT01798667 Phase 2 DA-8031;Placebo
25 A Study On Concentrations Of 16448 In Blood And The Safety Of This Compound In Healthy Males With Premature Ejaculation Completed NCT00537459 Phase 2 16448
26 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT) and Patient Reported Outcomes in Men With Premature Ejaculation (PE) Completed NCT02232425 Phase 2 IX-01;Placebo
27 Exploratory Study of Pagoclone in Men With Premature Ejaculation. Completed NCT00370981 Phase 2 pagoclone
28 Phase 2 Trial of PED-1 and PED-2 in Male Patients With Premature Ejaculation Completed NCT01203202 Phase 2 Clomipramine
29 A Study To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Two Oral Doses of GSK557296 in a Study in Men With Premature Ejaculation Completed NCT01021553 Phase 2 GSK557296;GSK557296;placebo
30 Safety, Tolerability, Pharmacokinetics and Efficacy of YHD1044 Completed NCT01419470 Phase 1, Phase 2 dapoxetine
31 A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation Recruiting NCT02571101 Phase 2 CDFR0812-15/25mg;CDFR0812-15/50mg;Condencia;CDFR0812-Placebo;Condencia-Placebo
32 Safety and Efficacy of Silodosin in the Treatment of Premature Ejaculation Recruiting NCT02581826 Phase 2 Silodosin;Placebo
33 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT), Patient Reported Outcomes and Safety in Men With Premature Ejaculation (PE) Active, not recruiting NCT03055806 Phase 2 IX-01 400 mg;Placebo;IX-01 800 mg;IX-01 1200 mg
34 A Safety and Efficacy Study of BOTOX® in Premature Ejaculation Terminated NCT01917006 Phase 2 OnabotulinumtoxinA;Normal Saline
35 Proof of Mechanism in ELT Completed NCT00861484 Phase 1 GSK958108;Placebo
36 A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation Completed NCT01184105 Phase 1 Intervention A;Intervention B
37 FTIH Study With GSK958108 Completed NCT00664365 Phase 1 GSK958108;Placebo
38 A Safety and Tolerability Study of Administration of PSD502 Completed NCT01183208 Phase 1 Intervention A;Intervention B;Intervention C;Intervention D;Intervention E
39 A First Time in Human Study in Healthy Male Volunteers for Compound GSK557296. Completed NCT00549211 Phase 1 GSK557296
40 Drug-Drug Interaction of Clomipramine HCl and Sildenafil Citrate in Healthy Males Completed NCT02028598 Phase 1 Treatment 1;Treatment 2;Treatment 3
41 A Pharmacodynamic Study of Dapoxetine Concomitantly Administered in Participants Taking Terazosin Completed NCT01366664 Phase 1 Treatment sequence 2;Treatment sequence 1
42 A Study to Characterize the Pharmacokinetics of DA-8031 in Healthy Male Subjects Completed NCT01104948 Phase 1 DA-8031;Placebo
43 A Study To Assess The Pharmacokinetics Of Different Modified Release Formulations Of GSK221149 In Healthy Adult Subjects Terminated NCT00449709 Phase 1 GSK221149
44 Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation Unknown status NCT00656552 Early Phase 1 Escitalopram
45 Male Reproductive Health of Floating Population: a Large-Scale Survey in Dongguan Unknown status NCT01901029
46 Management of Sexual Dysfunction With Bioresonance Technique Unknown status NCT02028013
47 The Impact and Benefit of Physical Activity on Premature Ejaculation Completed NCT02844998 dapoxetine 30 mg on demand
48 Research and Clinical Value of New Classification for Premature Ejaculation: Multi-Center Research Completed NCT02572037
49 Efficacy of a New Behavioral Treatment for Premature Ejaculation Using a Masturbation Aid Device: Star-Stop 3.0 Completed NCT03304808
50 A New Treatment for Premature Ejaculation? Completed NCT02297152

Search NIH Clinical Center for Premature Ejaculation

Cochrane evidence based reviews: premature ejaculation

Genetic Tests for Premature Ejaculation

Anatomical Context for Premature Ejaculation

MalaCards organs/tissues related to Premature Ejaculation:

39
Prostate, Skin, Testes, Heart, Brain, Liver, Kidney

Publications for Premature Ejaculation

Articles related to Premature Ejaculation:

(show top 50) (show all 633)
id Title Authors Year
1
Premature ejaculation: Pharmacotherapy vs group psychotherapy alone or in combination. ( 28679182 )
2017
2
Pharmacological/dynamic rehabilitative behavioural therapy for premature ejaculation: Results of a pilot study. ( 28679189 )
2017
3
Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial. ( 28497478 )
2017
4
Where do we come from and where are we going in the treatment of premature ejaculation? ( 28919100 )
2017
5
No Evidence for Long-Term Causal Associations Between Symptoms of Premature Ejaculation and Symptoms of Anxiety, Depression, and Sexual Distress in a Large, Population-Based Longitudinal Sample. ( 27982691 )
2017
6
Effects of paroxetine on intravaginal ejaculatory latency time in Egyptian patients with lifelong premature ejaculation as a function of serotonin transporter polymorphism. ( 27679962 )
2017
7
Circumcision does not have effect on premature ejaculation: A systematic review and meta-analysis. ( 28653427 )
2017
8
Current and emerging therapies in premature ejaculation: Where we are coming from, where we are going. ( 27704632 )
2017
9
Alterations in cortical thickness in nonmedicated premature ejaculation patients: A morphometric MRI study. ( 28736888 )
2017
10
Relationship Between Amyloid Precursor Protein in Seminal Plasma and Abnormal Penile Sympathetic Skin Response in Lifelong Premature Ejaculation. ( 28065363 )
2017
11
Premature Ejaculation: A Redundant Entity in the Era of Somatic Symptom Disorder? ( 28615783 )
2017
12
Re: Karabakan M, Bozkurt A, Hirik E, Celebi B, Akdemir S, Guzel O, Nuhoglu B. The prevalence of premature ejaculation in young Turkish men. Andrologia 2016; 24: 1-5. ( 28795478 )
2017
13
Editorial Comment to Silodosin versus naftopidil in the treatment of premature ejaculation: A prospective multicenter trial. ( 28733993 )
2017
14
Phosphodiesterase-5 inhibitors for premature ejaculation: a systematic review and meta-analysis. ( 28702510 )
2017
15
Re: Rasch Analysis of the Premature Ejaculation Diagnostic Tool (PEDT) and the International Index of Erectile Function (IIEF) in an Iranian Sample of Prostate Cancer Patients. ( 28505932 )
2017
16
Study of the prevalence of 5 HT-2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation. ( 28730747 )
2017
17
Study of the link between dopamine transporter gene polymorphisms and response to paroxetin and escitalopram in patients with lifelong premature ejaculation. ( 28904397 )
2017
18
Premature ejaculation is not a disease. ( 28556270 )
2017
19
Possible role of serum testosterone, gonadotropins and prolactin in patients with premature ejaculation. ( 28439908 )
2017
20
Significance of penile hypersensitivity in premature ejaculation. ( 28874780 )
2017
21
Efficacy of PDE5Is and SSRIs in men with premature ejaculation: a new systematic review and five meta-analyses. ( 28913588 )
2017
22
Phosphodiesterase Type 5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis. ( 28720356 )
2017
23
Lidocaine/prilocaine spray for premature ejaculation. ( 28408390 )
2017
24
Silodosin versus naftopidil in the treatment of premature ejaculation: A prospective multicenter trial. ( 28627033 )
2017
25
Ancient Chinese Fangzhongshu (Sexual Skills and Methods) Therapy for Premature Ejaculation. ( 28053946 )
2016
26
Relation of size of seminal vesicles on ultrasound to premature ejaculation. ( 27538475 )
2016
27
Current therapies for premature ejaculation. ( 27179987 )
2016
28
Efficacy and safety of Qiaoshao Formula () on patients with lifelong premature ejaculation of Gan (Liver) depression and Shen (Kidney) deficiency syndrome: A randomized controlled trial. ( 27170351 )
2016
29
Evaluating the content and quality of information about premature ejaculation on the Internet: what are men being exposed to ? ( 27135776 )
2016
30
Relationship between premature ejaculation and depression: A PRISMA-compliant systematic review and meta-analysis. ( 27583879 )
2016
31
Surgery is not indicated for the treatment of premature ejaculation. ( 27652232 )
2016
32
Emerging and investigational drugs for premature ejaculation. ( 27652222 )
2016
33
Rhodiola rosea, folic acid, zinc and biotin (EndEP(Ar)) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I-II study. ( 27698696 )
2016
34
Psychosexual therapy for premature ejaculation. ( 27652220 )
2016
35
Patient reported outcomes in the assessment of premature ejaculation. ( 27652219 )
2016
36
Attitudes of Sexual Medicine Specialists Toward Premature Ejaculation Diagnosis and Therapy. ( 27346231 )
2016
37
Is there a place for surgical treatment of premature ejaculation? ( 27652223 )
2016
38
The pathophysiology of acquired premature ejaculation. ( 27652216 )
2016
39
Premature ejaculation results from partners' mismatch: development and validation of index of intra-vaginal ejaculation latency time. ( 26865101 )
2016
40
[New data on the effectiveness of Tadalafil alone and in combination with NeyroDoz in treating erectile dysfunction associated with secondary premature ejaculation]. ( 28248021 )
2016
41
Re: SimA/es PaAso J, Jorge Pereira B.: New Therapeutic Perspectives in Premature Ejaculation (Urology 2016; 88:87-92). A Rebuttal: Premature Ejaculation is Not a Male Sexual Dysfunction. ( 26802798 )
2016
42
Diagnosis and Treatment of Premature Ejaculation by Urologists in South Korea. ( 28053952 )
2016
43
The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy: The PASSION Study. ( 26944775 )
2016
44
Association of STin2 VNTR Polymorphism of Serotonin Transporter Gene with Lifelong Premature Ejaculation: A Case-Control Study in Han Chinese Subjects. ( 27713390 )
2016
45
The epidemiology of premature ejaculation. ( 27652213 )
2016
46
Classification and definition of premature ejaculation. ( 27652214 )
2016
47
A Prospective Randomized Controlled Study to Compare Acupuncture and Dapoxetine for the Treatment of Premature Ejaculation. ( 27049323 )
2016
48
From the definition to the social impact of premature ejaculation. Expert consensus. ( 27908635 )
2016
49
Understanding the Pathophysiology of Premature Ejaculation: Bridging the Link between Pharmacological and Psychological Interventions. ( 27993112 )
2016
50
Initiators and Barriers to Discussion and Treatment of Premature Ejaculation Among Men and Their Partners in Asia Pacific - Results From a Web-based Survey. ( 27528556 )
2016

Variations for Premature Ejaculation

Expression for Premature Ejaculation

Search GEO for disease gene expression data for Premature Ejaculation.

Pathways for Premature Ejaculation

GO Terms for Premature Ejaculation

Cellular components related to Premature Ejaculation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.02 HTR1A HTR1B HTR2C SLC6A3 SLC6A4
2 presynapse GO:0098793 8.96 SLC6A3 SLC6A4

Biological processes related to Premature Ejaculation according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.93 HTR1A HTR1B HTR2C LEP PDE5A
2 response to drug GO:0042493 9.73 HTR1B HTR2C SLC6A3 SLC6A4
3 cellular response to retinoic acid GO:0071300 9.58 LEP SLC6A4
4 neurotransmitter transport GO:0006836 9.57 SLC6A3 SLC6A4
5 feeding behavior GO:0007631 9.56 HTR1B HTR2C
6 behavioral fear response GO:0001662 9.55 HTR1A HTR2C
7 neurotransmitter biosynthetic process GO:0042136 9.52 SLC6A3 SLC6A4
8 ammonium transmembrane transport GO:0072488 9.51 SLC6A3 SLC6A4
9 regulation of dopamine metabolic process GO:0042053 9.49 HTR1A SLC6A3
10 regulation of behavior GO:0050795 9.48 HTR1A HTR1B
11 monoamine transport GO:0015844 9.46 SLC6A3 SLC6A4
12 response to ethanol GO:0045471 9.46 HTR1B HTR3A LEP SLC6A3
13 response to cocaine GO:0042220 9.43 HTR1B HTR3A SLC6A3
14 dopamine uptake involved in synaptic transmission GO:0051583 9.4 SLC6A3 SLC6A4
15 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.37 HTR1A HTR1B
16 serotonin receptor signaling pathway GO:0007210 9.32 HTR1A HTR2C
17 vasoconstriction GO:0042310 9.13 HTR1A HTR1B SLC6A4
18 behavior GO:0007610 8.8 HTR1A HTR1B HTR2C

Molecular functions related to Premature Ejaculation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.61 HTR1A HTR1B HTR2C
2 drug binding GO:0008144 9.5 HTR1B HTR2C SLC6A3
3 neurotransmitter:sodium symporter activity GO:0005328 9.4 SLC6A3 SLC6A4
4 monoamine transmembrane transporter activity GO:0008504 9.37 SLC6A3 SLC6A4
5 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR1B HTR2C
6 dopamine:sodium symporter activity GO:0005330 9.26 SLC6A3 SLC6A4
7 G-protein coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR1B HTR2C
8 serotonin binding GO:0051378 8.92 HTR1A HTR1B HTR2C HTR3A

Sources for Premature Ejaculation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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