MCID: PRM003
MIFTS: 47

Premature Ejaculation

Categories: Mental diseases

Aliases & Classifications for Premature Ejaculation

Summaries for Premature Ejaculation

MalaCards based summary : Premature Ejaculation is related to social phobia and sexual disorder. An important gene associated with Premature Ejaculation is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Taste transduction. The drugs Tadalafil and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and brain, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 72 Premature ejaculation (PE) occurs when a man experiences orgasm and expels semen soon after sexual... more...

Related Diseases for Premature Ejaculation

Diseases related to Premature Ejaculation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 social phobia 30.1 HTR3A SLC6A4
2 sexual disorder 29.9 HTR1A PDE5A
3 irritable bowel syndrome 29.4 HTR3A SLC6A4
4 alexithymia 29.4 COMT HTR1A SLC6A4
5 anxiety 28.4 COMT HTR1A HTR2C HTR3A SLC6A3 SLC6A4
6 panic disorder 28.3 COMT HTR1A HTR2C HTR3A SLC6A4
7 attention deficit-hyperactivity disorder 28.0 COMT HTR1A HTR1B HTR2C SLC6A3 SLC6A4
8 disease of mental health 27.9 COMT HTR1A HTR2C PDE5A SLC6A3 SLC6A4
9 prostatitis 10.4
10 kleptomania 10.4 HTR1A SLC6A4
11 intermittent explosive disorder 10.3 HTR1A SLC6A4
12 agoraphobia 10.3 HTR1A SLC6A4
13 alcohol-induced mental disorder 10.3 SLC6A3 SLC6A4
14 alcoholic psychosis 10.3 SLC6A3 SLC6A4
15 pathological gambling 10.2 SLC6A3 SLC6A4
16 migraine without aura 10.2 HTR1A SLC6A4
17 amphetamine abuse 10.2 HTR1B SLC6A3
18 placental choriocarcinoma 10.1 LEP SLC6A4
19 rumination disorder 10.1 HTR1A HTR3A
20 endogenous depression 10.1 HTR1A SLC6A4
21 periodic limb movement disorder 10.1 HTR1A HTR2C SLC6A4
22 motion sickness 10.1 HTR1A HTR3A
23 aging 10.1
24 cocaine dependence 10.1 SLC6A3 SLC6A4
25 episodic pain syndrome, familial, 1 10.1
26 hyperthyroidism 10.1
27 paine syndrome 10.0
28 mungan syndrome 10.0
29 mucositis 10.0
30 hypogonadotropic hypogonadism 10.0
31 allergic hypersensitivity disease 10.0
32 hypogonadism 10.0
33 vaginitis 10.0
34 infertility 10.0
35 hypogonadotropism 10.0
36 amnestic disorder 10.0 HTR1A HTR3A
37 substance dependence 10.0 HTR1B SLC6A3 SLC6A4
38 machado-joseph disease 10.0 HTR1A SLC6A3
39 functional gastric disease 10.0 HTR3A PDE5A
40 serotonin syndrome 9.9 HTR1A HTR3A SLC6A4
41 dyspepsia 9.9 HTR1A HTR3A SLC6A4
42 generalized anxiety disorder 9.9 HTR1A HTR3A SLC6A4
43 blood group, i system 9.9
44 body mass index quantitative trait locus 11 9.9
45 body mass index quantitative trait locus 9 9.9
46 body mass index quantitative trait locus 8 9.9
47 body mass index quantitative trait locus 1 9.9
48 body mass index quantitative trait locus 4 9.9
49 body mass index quantitative trait locus 10 9.9
50 body mass index quantitative trait locus 7 9.9

Graphical network of the top 20 diseases related to Premature Ejaculation:



Diseases related to Premature Ejaculation

Symptoms & Phenotypes for Premature Ejaculation

GenomeRNAi Phenotypes related to Premature Ejaculation according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.1 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Premature Ejaculation:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 COMT HTR1A HTR1B HTR2C HTR3A LEP
2 endocrine/exocrine gland MP:0005379 9.8 COMT HTR1B HTR3A LEP SLC6A3 SLC6A4
3 homeostasis/metabolism MP:0005376 9.8 HTR2C HTR3A LEP SLC6A3 SLC6A4 COMT
4 integument MP:0010771 9.55 HTR2C HTR3A LEP SLC6A3 SLC6A4
5 muscle MP:0005369 9.43 HTR1B HTR2C HTR3A LEP SLC6A3 SLC6A4
6 nervous system MP:0003631 9.17 COMT HTR1A HTR2C HTR3A LEP SLC6A3

Drugs & Therapeutics for Premature Ejaculation

Drugs for Premature Ejaculation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tadalafil Approved, Investigational Phase 4,Phase 3 171596-29-5 110635
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 77-92-9 311
3 Sildenafil Citrate Phase 4,Phase 3,Phase 2,Phase 1 171599-83-0
4 Vasodilator Agents Phase 4,Phase 2,Phase 1
5 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
6 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
7 Citrate Nutraceutical Phase 4,Phase 2,Phase 1
8
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Phase 1 137-58-6 3676
9
Clomipramine Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 303-49-1 2801
10
Paroxetine Approved, Investigational Phase 3 61869-08-7 43815
11
Prilocaine Approved Phase 2, Phase 3,Phase 1 721-50-6 4906
12
Norflurane Approved, Investigational Phase 2, Phase 3 811-97-2
13
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
14
Serotonin Phase 3,Phase 2,Phase 1,Early Phase 1 50-67-9 5202
15 Central Nervous System Depressants Phase 3,Phase 2,Phase 1
16 Serotonin Agents Phase 3,Phase 2,Phase 1,Early Phase 1
17 Serotonin Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
18 Sodium Channel Blockers Phase 3,Phase 2
19 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Early Phase 1
20 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
21 Anesthetics Phase 3,Phase 2,Phase 1
22 Anesthetics, Local Phase 3,Phase 2,Phase 1
23 Diuretics, Potassium Sparing Phase 3,Phase 2
24 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Early Phase 1
25 Anti-Arrhythmia Agents Phase 3,Phase 2
26 Antidepressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
27 Antidepressive Agents, Second-Generation Phase 3,Early Phase 1
28 Antidepressive Agents, Tricyclic Phase 3,Phase 2,Phase 1
29 Psychotropic Drugs Phase 3,Phase 2,Phase 1,Early Phase 1
30 EMLA Phase 2, Phase 3,Phase 1
31 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
32 Vardenafil Dihydrochloride Phase 3
33 Cytochrome P-450 Enzyme Inhibitors Phase 3
34 Analgesics Phase 3
35 Narcotics Phase 3
36 Analgesics, Opioid Phase 3
37
Silodosin Approved Phase 2 160970-54-7
38
Acetylcholine Approved Phase 2 51-84-3 187
39 Adrenergic Agents Phase 2,Phase 1
40 Adrenergic alpha-1 Receptor Antagonists Phase 2,Phase 1
41 Adrenergic alpha-Antagonists Phase 2,Phase 1
42 Adrenergic Antagonists Phase 2,Phase 1
43 Cholinergic Agents Phase 2,Early Phase 1
44 Diketopiperazines Phase 2,Phase 1
45 Anti-Bacterial Agents Phase 2,Phase 1
46 Anti-Infective Agents Phase 2,Phase 1
47 abobotulinumtoxinA Phase 2
48 Neuromuscular Agents Phase 2
49 onabotulinumtoxinA Phase 2
50 Botulinum Toxins Phase 2

Interventional clinical trials:

(show top 50) (show all 58)

# Name Status NCT ID Phase Drugs
1 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Completed NCT02939495 Phase 4 Dapoxetine/Sildenafil 30/50 mg film coated tablet
2 An Observational Study of Men With Premature Ejaculation Who Are Treated With Dapoxetine Hydrochloride or Alternate Care Defined as Any Treatment Other Than Dapoxetine Hydrochloride Completed NCT01021670 Phase 4 Dapoxetine hydrochloride
3 PRILIGY Usage Patterns in Selected Populations Completed NCT01273545 Phase 4 PRILIGY (dapoxetine hydrochloride)
4 The Safety of Dapoxetine/Tadalafil Combination Therapy Recruiting NCT03177746 Phase 4 Dapoxetine/Tadalafil 30/20 mg film coated tablet
5 Efficacy of Promescent Lidocaine Spray in Men With Premature Ejaculation Unknown status NCT02241460 Phase 3 Placebo;Promescent Lidocaine Spray
6 Efficacy and Safety of Paroxetine Daily Doses of 15 mg and 20 mg in the Treatment of Premature Ejaculation Completed NCT01024491 Phase 3 paroxetine;paroxetine;placebo
7 Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation Completed NCT00556478 Phase 2, Phase 3 PSD502, contains a mixture of lidocaine and prilocaine;Placebo
8 Trial of PED-1 in Male Patients With Premature Ejaculation Completed NCT01439984 Phase 3 Clomipramine
9 The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy Completed NCT01063881 Phase 3 Dapoxetine
10 A Study to Evaluate Intravaginal Ejaculation Time in Men With and Without Premature Ejaculation Completed NCT00210678 Phase 3
11 A Study of Withdrawal Effects With Dapoxetine in the Treatment of Premature Ejaculation Completed NCT00210613 Phase 3 Dapoxetine
12 Assessment of Efficacy and Safety of UK-390,957 in Men With Premature Ejaculation Completed NCT00143117 Phase 2, Phase 3 UK-390,957
13 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00210704 Phase 3 Dapoxetine
14 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00229073 Phase 3 dapoxetine
15 Assessment Of Efficacy and Safety UK-390,957 In Men With Premature Ejaculation Completed NCT00219635 Phase 2, Phase 3 UK-390,957
16 Assessment Of Efficacy and Safety Of UK-390,957 In Men With Premature Ejaculation Completed NCT00219583 Phase 2, Phase 3 UK-390,957
17 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00211094 Phase 3 Dapoxetine
18 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation. Completed NCT00211107 Phase 3 Dapoxetine
19 Concomitant Use of PriLigy in Men Treated for Erectile Dysfunction Completed NCT01063855 Phase 3 Placebo;Dapoxetine;PDE5I (phosphodiesterase-5 inhibitor)
20 Assessment Of Safety Of UK-390,957 Completed NCT00219609 Phase 2, Phase 3 UK-390,957
21 An Open-Label Study of the Long-Term Safety of Dapoxetine HCl in the Treatment of Rapid Ejaculation Completed NCT01230762 Phase 3 dapoxetine
22 Study to Evaluate Efficacy and Safety in Male Subjects With Premature Ejaculation Terminated NCT00983736 Phase 3 Tramadol Hydrochloride;Placebo
23 Study to Evaluate Efficacy and Safety in Males Subjects With Premature Ejaculation Terminated NCT00983151 Phase 3 Tramadol Hydrochloride & Placebo
24 A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation Unknown status NCT02571101 Phase 2 CDFR0812-15/25mg;CDFR0812-15/50mg;Condencia;CDFR0812-Placebo;Condencia-Placebo
25 Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation Unknown status NCT01798667 Phase 2 DA-8031;Placebo
26 Safety and Efficacy of Silodosin in the Treatment of Premature Ejaculation Unknown status NCT02581826 Phase 2 Silodosin;Placebo
27 A Study On Concentrations Of 16448 In Blood And The Safety Of This Compound In Healthy Males With Premature Ejaculation Completed NCT00537459 Phase 2 16448
28 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT) and Patient Reported Outcomes in Men With Premature Ejaculation (PE) Completed NCT02232425 Phase 2 IX-01;Placebo
29 Phase 2 Trial of PED-1 and PED-2 in Male Patients With Premature Ejaculation Completed NCT01203202 Phase 2 Clomipramine
30 A Study To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Two Oral Doses of GSK557296 in a Study in Men With Premature Ejaculation Completed NCT01021553 Phase 2 GSK557296;GSK557296;placebo
31 Exploratory Study of Pagoclone in Men With Premature Ejaculation. Completed NCT00370981 Phase 2 pagoclone
32 Safety, Tolerability, Pharmacokinetics and Efficacy of YHD1044 Completed NCT01419470 Phase 1, Phase 2 dapoxetine
33 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT), Patient Reported Outcomes and Safety in Men With Premature Ejaculation (PE) Active, not recruiting NCT03055806 Phase 2 IX-01 400 mg;Placebo;IX-01 800 mg;IX-01 1200 mg
34 A Safety and Efficacy Study of BOTOX® in Premature Ejaculation Terminated NCT01917006 Phase 2 OnabotulinumtoxinA;Normal Saline
35 Proof of Mechanism in ELT Completed NCT00861484 Phase 1 GSK958108;Placebo
36 A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation Completed NCT01184105 Phase 1 Intervention A;Intervention B
37 FTIH Study With GSK958108 Completed NCT00664365 Phase 1 GSK958108;Placebo
38 A Safety and Tolerability Study of Administration of PSD502 Completed NCT01183208 Phase 1 Intervention A;Intervention B;Intervention C;Intervention D;Intervention E
39 A First Time in Human Study in Healthy Male Volunteers for Compound GSK557296. Completed NCT00549211 Phase 1 GSK557296
40 Drug-Drug Interaction of Clomipramine HCl and Sildenafil Citrate in Healthy Males Completed NCT02028598 Phase 1 Treatment 1;Treatment 2;Treatment 3
41 A Pharmacodynamic Study of Dapoxetine Concomitantly Administered in Participants Taking Terazosin Completed NCT01366664 Phase 1 Treatment sequence 2;Treatment sequence 1
42 A Study To Assess The Pharmacokinetics Of Different Modified Release Formulations Of GSK221149 In Healthy Adult Subjects Terminated NCT00449709 Phase 1 GSK221149
43 Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation Unknown status NCT00656552 Early Phase 1 Escitalopram
44 Male Reproductive Health of Floating Population: a Large-Scale Survey in Dongguan Unknown status NCT01901029
45 Management of Sexual Dysfunction With Bioresonance Technique Unknown status NCT02028013
46 The Impact and Benefit of Physical Activity on Premature Ejaculation Completed NCT02844998 dapoxetine 30 mg on demand
47 Research and Clinical Value of New Classification for Premature Ejaculation: Multi-Center Research Completed NCT02572037
48 Efficacy of a New Behavioral Treatment for Premature Ejaculation Using a Masturbation Aid Device: Star-Stop 3.0 Completed NCT03304808
49 Effect of Exercise on Premature Ejaculation Completed NCT02984592
50 A New Treatment for Premature Ejaculation? Completed NCT02297152

Search NIH Clinical Center for Premature Ejaculation

Cochrane evidence based reviews: premature ejaculation

Genetic Tests for Premature Ejaculation

Anatomical Context for Premature Ejaculation

MalaCards organs/tissues related to Premature Ejaculation:

38
Prostate, Skin, Brain, Testes, Heart, Liver, Kidney

Publications for Premature Ejaculation

Articles related to Premature Ejaculation:

(show top 50) (show all 646)
# Title Authors Year
1
Effects of the dopamine D<sub>3</sub>receptor agonist 7-hydroxy-2-(di-N-propylamino) tetralin in hyperthyroidism-induced premature ejaculation rat model. ( 29369372 )
2018
2
Re: Re: Karabakan M, Bozkurt A, Hirik E, Celebi B, Akdemir S, Guzel O, Nuhoglu B. The prevalence of premature ejaculation in young Turkish men. Andrologia 2016; 24: 1-5. ( 29336072 )
2018
3
Penile sensory thresholds in subtypes of premature ejaculation: implications of comorbid erectile dysfunction. ( 29405168 )
2018
4
Visceral adiposity index is associated with premature ejaculation inversely: a cross-sectional study. ( 29338524 )
2018
5
Phosphodiesterase-5 inhibitors for premature ejaculation: a systematic review and meta-analysis. ( 28702510 )
2017
6
Where do we come from and where are we going in the treatment of premature ejaculation? ( 28919100 )
2017
7
Premature Ejaculation: A Redundant Entity in the Era of Somatic Symptom Disorder? ( 28615783 )
2017
8
Efficacy of PDE5Is and SSRIs in men with premature ejaculation: a new systematic review and five meta-analyses. ( 28913588 )
2017
9
Study of the prevalence of 5 HT-2C receptor gene polymorphisms in Egyptian patients with lifelong premature ejaculation. ( 28730747 )
2017
10
Silodosin versus naftopidil in the treatment of premature ejaculation: A prospective multicenter trial. ( 28627033 )
2017
11
Lidocaine/prilocaine spray for premature ejaculation. ( 28408390 )
2017
12
Alterations in cortical thickness in nonmedicated premature ejaculation patients: A morphometric MRI study. ( 28736888 )
2017
13
Editorial Comment to Silodosin versus naftopidil in the treatment of premature ejaculation: A prospective multicenter trial. ( 28733993 )
2017
14
Significance of penile hypersensitivity in premature ejaculation. ( 28874780 )
2017
15
The prevalence of an excessive prepuce and the effects of distal circumcision on premature ejaculation. ( 29071143 )
2017
16
Re: Silodosin versus Naftopidil in the Treatment of Premature Ejaculation: AA Prospective Multicenter Trial. ( 29144913 )
2017
17
Effects of paroxetine on intravaginal ejaculatory latency time in Egyptian patients with lifelong premature ejaculation as a function of serotonin transporter polymorphism. ( 27679962 )
2017
18
Relationship Between Amyloid Precursor Protein in Seminal Plasma and Abnormal Penile Sympathetic Skin Response in Lifelong Premature Ejaculation. ( 28065363 )
2017
19
Circumcision does not have effect on premature ejaculation: A systematic review and meta-analysis. ( 28653427 )
2017
20
Study of the link between dopamine transporter gene polymorphisms and response to paroxetin and escitalopram in patients with lifelong premature ejaculation. ( 28904397 )
2017
21
Possible role of serum testosterone, gonadotropins and prolactin in patients with premature ejaculation. ( 28439908 )
2017
22
Transcutaneous neuromuscular electrical stimulation may be beneficial in the treatment of premature ejaculation. ( 29150283 )
2017
23
Pharmacological/dynamic rehabilitative behavioural therapy for premature ejaculation: Results of a pilot study. ( 28679189 )
2017
24
Efficacy of combined traditional Chinese medicine spray with premature ejaculation desensitization therapy for the treatment of primary premature ejaculation. ( 29085387 )
2017
25
Premature ejaculation is not a disease. ( 28556270 )
2017
26
Sexual Cognitions, Trait Anxiety, Sexual Anxiety, and Distress in Men With Different Subtypes of Premature Ejaculation and in Their Partners. ( 29161211 )
2017
27
Re: Karabakan M, Bozkurt A, Hirik E, Celebi B, Akdemir S, Guzel O, Nuhoglu B. The prevalence of premature ejaculation in young Turkish men. Andrologia 2016; 24: 1-5. ( 28795478 )
2017
28
Phosphodiesterase Type 5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis. ( 28720356 )
2017
29
Current and emerging therapies in premature ejaculation: Where we are coming from, where we are going. ( 27704632 )
2017
30
Re: Validity of Premature Ejaculation Diagnostic Tool and its Association with International Index of Erectile Function-15 in Chinese Men with Evidence-Based-Defined Premature Ejaculation. ( 29370617 )
2017
31
Preliminary Evidence for an Association Between Variants of the Catechol-O-Methyltransferase (COMT) Gene and Premature Ejaculation. ( 29198511 )
2017
32
No Evidence for Long-Term Causal Associations Between Symptoms of Premature Ejaculation and Symptoms of Anxiety, Depression, and Sexual Distress in a Large, Population-Based Longitudinal Sample. ( 27982691 )
2017
33
Tolerability and adequate therapeutic dosage of oral clomipramine for the treatment of premature ejaculation: A randomized, double-blind, placebo-controlled, fixed-dose, parallel-grouped clinical study. ( 29203842 )
2017
34
Premature ejaculation: Pharmacotherapy vs group psychotherapy alone or in combination. ( 28679182 )
2017
35
Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial. ( 28497478 )
2017
36
Re: Rasch Analysis of the Premature Ejaculation Diagnostic Tool (PEDT) and the International Index of Erectile Function (IIEF) in an Iranian Sample of Prostate Cancer Patients. ( 28505932 )
2017
37
Premature ejaculation: challenging new and the old concepts. ( 29259775 )
2017
38
Efficacy and safety of phosphodiesterase type 5 inhibitors on primary premature ejaculation in men receiving selective serotonin reuptake inhibitors therapy: a systematic review and meta-analysis. ( 26791333 )
2016
39
Comparison Between Tadalafil Plus Paroxetine and Paroxetine Alone in the Treatment of Premature Ejaculation. ( 26981497 )
2016
40
Effectiveness of 'on demand' silodosin in the treatment of premature ejaculation in patients dissatisfied with dapoxetine: a randomized control study. ( 27729995 )
2016
41
Comparison of Treatment Emergent Adverse Events in Men With Premature Ejaculation Treated With Dapoxetine and Alternate Oral Treatments: Results From a Large Multinational Observational Trial. ( 26805941 )
2016
42
Biallelic and Triallelic 5-Hydroxytyramine Transporter Gene-Linked Polymorphic Region (5- HTTLPR) Polymorphisms and Their Relationship with Lifelong Premature Ejaculation: A Case-Control Study in a Chinese Population. ( 27311544 )
2016
43
Association of STin2 VNTR Polymorphism of Serotonin Transporter Gene with Lifelong Premature Ejaculation: A Case-Control Study in Han Chinese Subjects. ( 27713390 )
2016
44
The prevalence of premature ejaculation in young Turkish men. ( 26803992 )
2016
45
The design and methodology of premature ejaculation interventional studies. ( 27652224 )
2016
46
Efficacy and safety of dapoxetine in treatment of premature ejaculation: an evidence-based review. ( 27456527 )
2016
47
The drug treatment of premature ejaculation. ( 27652221 )
2016
48
Somatosensory evoked potentials assess the efficacy of circumcision for premature ejaculation. ( 27193064 )
2016
49
Current therapies for premature ejaculation. ( 27179987 )
2016
50
The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy: The PASSION Study. ( 26944775 )
2016

Variations for Premature Ejaculation

Expression for Premature Ejaculation

Search GEO for disease gene expression data for Premature Ejaculation.

Pathways for Premature Ejaculation

GO Terms for Premature Ejaculation

Cellular components related to Premature Ejaculation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.13 COMT HTR3A SLC6A3
2 integral component of plasma membrane GO:0005887 9.02 HTR1A HTR1B HTR2C SLC6A3 SLC6A4

Biological processes related to Premature Ejaculation according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.75 HTR1B HTR2C HTR3A
2 neurotransmitter transport GO:0006836 9.59 SLC6A3 SLC6A4
3 feeding behavior GO:0007631 9.58 HTR1B HTR2C
4 behavioral fear response GO:0001662 9.57 HTR1A HTR2C
5 G-protein coupled serotonin receptor signaling pathway GO:0098664 9.56 HTR1A HTR1B
6 response to ethanol GO:0045471 9.56 HTR1B HTR3A LEP SLC6A3
7 response to drug GO:0042493 9.55 COMT HTR1B HTR2C SLC6A3 SLC6A4
8 neurotransmitter biosynthetic process GO:0042136 9.54 SLC6A3 SLC6A4
9 ammonium transmembrane transport GO:0072488 9.52 SLC6A3 SLC6A4
10 regulation of dopamine metabolic process GO:0042053 9.51 HTR1A SLC6A3
11 response to cocaine GO:0042220 9.5 HTR1B HTR3A SLC6A3
12 regulation of behavior GO:0050795 9.49 HTR1A HTR1B
13 monoamine transport GO:0015844 9.48 SLC6A3 SLC6A4
14 dopamine catabolic process GO:0042420 9.46 COMT SLC6A3
15 dopamine uptake involved in synaptic transmission GO:0051583 9.43 SLC6A3 SLC6A4
16 serotonin receptor signaling pathway GO:0007210 9.4 HTR1A HTR2C
17 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.37 HTR1A HTR1B
18 vasoconstriction GO:0042310 9.13 HTR1A HTR1B SLC6A4
19 behavior GO:0007610 8.8 HTR1A HTR1B HTR2C
20 signal transduction GO:0007165 10.02 HTR1A HTR1B HTR2C HTR3A LEP PDE5A

Molecular functions related to Premature Ejaculation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.5 HTR1B HTR2C SLC6A3
2 neurotransmitter:sodium symporter activity GO:0005328 9.4 SLC6A3 SLC6A4
3 monoamine transmembrane transporter activity GO:0008504 9.37 SLC6A3 SLC6A4
4 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR1B HTR2C
5 dopamine:sodium symporter activity GO:0005330 9.26 SLC6A3 SLC6A4
6 G-protein coupled serotonin receptor activity GO:0004993 9.13 HTR1A HTR1B HTR2C
7 serotonin binding GO:0051378 8.92 HTR1A HTR1B HTR2C HTR3A

Sources for Premature Ejaculation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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