Aliases & Classifications for Premature Ejaculation

Summaries for Premature Ejaculation

MalaCards based summary : Premature Ejaculation is related to prostatitis and adult brainstem astrocytoma, and has symptoms including decreased libido An important gene associated with Premature Ejaculation is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Taste transduction. The drugs Alfuzosin and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include prostate, skin and testes, and related phenotypes are Decreased viability and behavior/neurological

Wikipedia : 71 Premature ejaculation (PE) occurs when a man experiences orgasm and expels semen soon after sexual... more...

Related Diseases for Premature Ejaculation

Diseases related to Premature Ejaculation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 prostatitis 10.3
2 adult brainstem astrocytoma 10.2 HTR1A SLC6A4
3 apperceptive agnosia 10.2 HTR1A SLC6A4
4 kidney pelvis papillary carcinoma 10.2 HTR1A SLC6A4
5 chronic eosinophilic pneumonia 10.2 HTR1A SLC6A4
6 intracranial cavernous angioma 10.2 SLC6A3 SLC6A4
7 splenic abscess 10.2 SLC6A3 SLC6A4
8 luxation of globe 10.2 HTR1A SLC6A4
9 pyromania 10.2 SLC6A3 SLC6A4
10 hypoglycemic coma 10.2 HTR1A SLC6A4
11 colorectal adenocarcinoma 10.2 SLC6A3 SLC6A4
12 strongyloidiasis 10.1 SLC6A3 SLC6A4
13 interstitial emphysema 10.1 HTR2C SLC6A4
14 aphasia 10.1 HTR1A PDE5A
15 anxiety disorder 10.1 LEP SLC6A4
16 waardenburg's syndrome 10.1 HTR1A HTR2C SLC6A4
17 primary angle-closure glaucoma 10.1 HTR1A HTR2C SLC6A4
18 keratosis 10.1 HTR1A HTR2C SLC6A4
19 alzheimer disease 17 10.1 HTR1A HTR2C SLC6A4
20 littre gland carcinoma 10.1 HTR1B SLC6A3
21 ornithosis 10.1 HTR3A SLC6A4
22 abnormal pupillary function 10.0 HTR1A HTR3A
23 tinea pedis 10.0 HTR1A SLC6A3 SLC6A4
24 deafness, autosomal recessive 20 10.0 HTR3A SLC6A4
25 mixed lacrimal gland cancer 10.0 HTR1A HTR3A
26 brain glioblastoma multiforme 10.0 HTR1A SLC6A3 SLC6A4
27 transmitted_by 10.0 SLC6A3 SLC6A4
28 mucinous adenocarcinoma 10.0 HTR1B SLC6A3 SLC6A4
29 hypereosinophilic syndrome 10.0 HTR1B SLC6A3 SLC6A4
30 carotid stenosis 10.0 SLC6A3 SLC6A4
31 sydenham chorea 10.0 HTR1B PDE5A SLC6A4
32 scleral staphyloma 10.0 HTR3A PDE5A
33 siberian tick typhus 10.0 HTR1A HTR3A
34 cytomegalic congenital adrenal hypoplasia 9.9 HTR3A SLC6A4
35 infertility 9.9
36 hypogonadotropism 9.9
37 hyperthyroidism 9.9
38 mucositis 9.9
39 hypogonadism 9.9
40 vaginitis 9.9
41 tuberculous peritonitis 9.9 HTR3A SLC6A4
42 mandibular cancer 9.9 HTR1A HTR3A SLC6A4
43 hepatitis b reinfection following liver transplantation 9.9 HTR1A HTR3A SLC6A4
44 postencephalitic parkinson disease 9.9 HTR1A HTR3A SLC6A4
45 multiple personality disorder 9.9 HTR1A HTR1B HTR2C SLC6A4
46 fechtner syndrome 9.9 HTR1A HTR3A SLC6A4
47 benign epilepsy with centrotemporal spikes 9.9 HTR1A HTR1B HTR2C SLC6A4
48 sweat gland cancer 9.9 HTR3A SLC6A4
49 atrial fibrillation, familial, 10 9.9 HTR1A HTR3A SLC6A4
50 dry eye syndrome 9.9 HTR1A HTR2C PDE5A SLC6A4

Graphical network of the top 20 diseases related to Premature Ejaculation:



Diseases related to Premature Ejaculation

Symptoms & Phenotypes for Premature Ejaculation

UMLS symptoms related to Premature Ejaculation:


decreased libido

GenomeRNAi Phenotypes related to Premature Ejaculation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 HTR1A HTR3A SLC6A4
2 Decreased viability GR00381-A-3 9.1 HTR1A HTR3A SLC6A4

MGI Mouse Phenotypes related to Premature Ejaculation:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 HTR1A HTR1B HTR2C HTR3A LEP SLC6A3
2 endocrine/exocrine gland MP:0005379 9.72 HTR1B HTR3A LEP SLC6A3 SLC6A4
3 mortality/aging MP:0010768 9.7 HTR1B HTR2C HTR3A LEP SLC6A3 SLC6A4
4 integument MP:0010771 9.65 HTR2C HTR3A LEP SLC6A3 SLC6A4
5 muscle MP:0005369 9.43 HTR1B HTR2C HTR3A LEP SLC6A3 SLC6A4
6 nervous system MP:0003631 9.1 HTR1A HTR2C HTR3A LEP SLC6A3 SLC6A4

Drugs & Therapeutics for Premature Ejaculation

Drugs for Premature Ejaculation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alfuzosin Approved, Investigational Phase 4 81403-80-7 2092
2 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
3 Adrenergic Agents Phase 4,Phase 2,Phase 1
4 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 2,Phase 1
5 Adrenergic alpha-Antagonists Phase 4,Phase 2,Phase 1
6 Adrenergic Antagonists Phase 4,Phase 2,Phase 1
7 Phosphodiesterase 5 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
8 Phosphodiesterase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
9 Sildenafil Citrate Phase 4,Phase 3,Phase 2,Phase 1 171599-83-0
10 Vasodilator Agents Phase 4,Phase 2,Phase 1
11 Citrate Nutraceutical Phase 4,Phase 2,Phase 1
12
Citric Acid Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 77-92-9 311
13
Lidocaine Approved, Vet_approved Phase 3,Phase 2,Phase 1 137-58-6 3676
14
Paroxetine Approved, Investigational Phase 3 61869-08-7 43815
15
Prilocaine Approved Phase 2, Phase 3,Phase 1 721-50-6 4906
16
Clomipramine Approved, Vet_approved Phase 3,Phase 2,Phase 1 303-49-1 2801
17
Tadalafil Approved, Investigational Phase 3 171596-29-5 110635
18
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
19
Norflurane Investigational Phase 2, Phase 3 811-97-2
20 Anesthetics Phase 3,Phase 2,Phase 1
21 Anesthetics, Local Phase 3,Phase 2,Phase 1
22 Anti-Arrhythmia Agents Phase 3,Phase 2
23 Central Nervous System Depressants Phase 3,Phase 2,Phase 1
24 Diuretics, Potassium Sparing Phase 3,Phase 2
25 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Early Phase 1
26 Sodium Channel Blockers Phase 3,Phase 2
27 Antidepressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
28 Antidepressive Agents, Second-Generation Phase 3,Early Phase 1
29 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
30 Cytochrome P-450 Enzyme Inhibitors Phase 3
31 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
32 Psychotropic Drugs Phase 3,Phase 2,Phase 1,Early Phase 1
33
Serotonin Phase 3,Phase 2,Phase 1,Early Phase 1 50-67-9 5202
34 Serotonin Agents Phase 3,Phase 2,Phase 1,Early Phase 1
35 Serotonin Uptake Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
36 EMLA Phase 2, Phase 3,Phase 1
37 Antidepressive Agents, Tricyclic Phase 3,Phase 2,Phase 1
38 Vardenafil Dihydrochloride Phase 3
39 Analgesics Phase 3
40 Analgesics, Opioid Phase 3
41 Narcotics Phase 3
42
Acetylcholine Approved Phase 2 51-84-3 187
43
Silodosin Approved Phase 2 160970-54-7
44 Cholinergic Agents Phase 2,Early Phase 1
45 Anti-Bacterial Agents Phase 2,Phase 1
46 Anti-Infective Agents Phase 2,Phase 1
47 Diketopiperazines Phase 2,Phase 1
48 abobotulinumtoxinA Phase 2
49 Botulinum Toxins Phase 2
50 Botulinum Toxins, Type A Phase 2

Interventional clinical trials:

(show top 50) (show all 60)
id Name Status NCT ID Phase
1 An Observational Study of Men With Premature Ejaculation Who Are Treated With Dapoxetine Hydrochloride or Alternate Care Defined as Any Treatment Other Than Dapoxetine Hydrochloride Completed NCT01021670 Phase 4
2 PRILIGY Usage Patterns in Selected Populations Completed NCT01273545 Phase 4
3 Male Sexual Health Questionnaire (MSHQ) - Sexual Function Study Completed NCT00427882 Phase 4
4 SAMBA: Sexuality And Management of Benign Prostatic Hyperplasia With Alfuzosin Completed NCT00486785 Phase 4
5 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Recruiting NCT02939495 Phase 4
6 The Safety of Dapoxetine/Tadalafil Combination Therapy Not yet recruiting NCT03177746 Phase 4
7 Efficacy of Promescent Lidocaine Spray in Men With Premature Ejaculation Unknown status NCT02241460 Phase 3
8 Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation Completed NCT00556478 Phase 2, Phase 3
9 Efficacy and Safety of Paroxetine Daily Doses of 15 mg and 20 mg in the Treatment of Premature Ejaculation Completed NCT01024491 Phase 3
10 Trial of PED-1 in Male Patients With Premature Ejaculation Completed NCT01439984 Phase 3
11 A Study to Evaluate Intravaginal Ejaculation Time in Men With and Without Premature Ejaculation Completed NCT00210678 Phase 3
12 The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy Completed NCT01063881 Phase 3
13 A Study of Withdrawal Effects With Dapoxetine in the Treatment of Premature Ejaculation Completed NCT00210613 Phase 3
14 Assessment of Efficacy and Safety of UK-390,957 in Men With Premature Ejaculation Completed NCT00143117 Phase 2, Phase 3
15 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00210704 Phase 3
16 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00229073 Phase 3
17 Assessment Of Efficacy and Safety UK-390,957 In Men With Premature Ejaculation Completed NCT00219635 Phase 2, Phase 3
18 Assessment Of Efficacy and Safety Of UK-390,957 In Men With Premature Ejaculation Completed NCT00219583 Phase 2, Phase 3
19 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation Completed NCT00211094 Phase 3
20 A Study of the Effectiveness and Safety of Dapoxetine in the Treatment of Men With Premature Ejaculation. Completed NCT00211107 Phase 3
21 Concomitant Use of PriLigy in Men Treated for Erectile Dysfunction Completed NCT01063855 Phase 3
22 Assessment Of Safety Of UK-390,957 Completed NCT00219609 Phase 2, Phase 3
23 An Open-Label Study of the Long-Term Safety of Dapoxetine HCl in the Treatment of Rapid Ejaculation Completed NCT01230762 Phase 3
24 Study to Evaluate Efficacy and Safety in Male Subjects With Premature Ejaculation Terminated NCT00983736 Phase 3
25 Study to Evaluate Efficacy and Safety in Males Subjects With Premature Ejaculation Terminated NCT00983151 Phase 3
26 Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation Unknown status NCT01798667 Phase 2
27 High-Intensity Focused Ultrasound in Treating Patients With Localized Prostate Cancer Unknown status NCT01194648 Phase 2
28 A Study On Concentrations Of 16448 In Blood And The Safety Of This Compound In Healthy Males With Premature Ejaculation Completed NCT00537459 Phase 2
29 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT) and Patient Reported Outcomes in Men With Premature Ejaculation (PE) Completed NCT02232425 Phase 2
30 Exploratory Study of Pagoclone in Men With Premature Ejaculation. Completed NCT00370981 Phase 2
31 Phase 2 Trial of PED-1 and PED-2 in Male Patients With Premature Ejaculation Completed NCT01203202 Phase 2
32 A Study To Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Two Oral Doses of GSK557296 in a Study in Men With Premature Ejaculation Completed NCT01021553 Phase 2
33 Safety, Tolerability, Pharmacokinetics and Efficacy of YHD1044 Completed NCT01419470 Phase 1, Phase 2
34 A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation Recruiting NCT02571101 Phase 2
35 A Safety and Efficacy Study of BOTOX® in Premature Ejaculation Recruiting NCT01917006 Phase 2
36 Safety and Efficacy of Silodosin in the Treatment of Premature Ejaculation Recruiting NCT02581826 Phase 2
37 IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT), Patient Reported Outcomes and Safety in Men With Premature Ejaculation (PE) Recruiting NCT03055806 Phase 2
38 Proof of Mechanism in ELT Completed NCT00861484 Phase 1
39 A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation Completed NCT01184105 Phase 1
40 FTIH Study With GSK958108 Completed NCT00664365 Phase 1
41 A Safety and Tolerability Study of Administration of PSD502 Completed NCT01183208 Phase 1
42 A First Time in Human Study in Healthy Male Volunteers for Compound GSK557296. Completed NCT00549211 Phase 1
43 Drug-Drug Interaction of Clomipramine HCl and Sildenafil Citrate in Healthy Males Completed NCT02028598 Phase 1
44 A Pharmacodynamic Study of Dapoxetine Concomitantly Administered in Participants Taking Terazosin Completed NCT01366664 Phase 1
45 A Study to Characterize the Pharmacokinetics of DA-8031 in Healthy Male Subjects Completed NCT01104948 Phase 1
46 A Study To Assess The Pharmacokinetics Of Different Modified Release Formulations Of GSK221149 In Healthy Adult Subjects Terminated NCT00449709 Phase 1
47 Safety and Efficacy of Escitalopram in the Treatment of Premature Ejaculation Unknown status NCT00656552 Early Phase 1
48 Male Reproductive Health of Floating Population: a Large-Scale Survey in Dongguan Unknown status NCT01901029
49 Management of Sexual Dysfunction With Bioresonance Technique Unknown status NCT02028013
50 SSRI Effects on Semen Parameters in Men Unknown status NCT00385762

Search NIH Clinical Center for Premature Ejaculation

Cochrane evidence based reviews: premature ejaculation

Genetic Tests for Premature Ejaculation

Anatomical Context for Premature Ejaculation

MalaCards organs/tissues related to Premature Ejaculation:

39
Prostate, Skin, Testes, Heart, Brain, Liver, Kidney

Publications for Premature Ejaculation

Articles related to Premature Ejaculation:

(show top 50) (show all 610)
id Title Authors Year
1
Current and emerging therapies in premature ejaculation: Where we are coming from, where we are going. ( 27704632 )
2017
2
No Evidence for Long-Term Causal Associations Between Symptoms of Premature Ejaculation and Symptoms of Anxiety, Depression, and Sexual Distress in a Large, Population-Based Longitudinal Sample. ( 27982691 )
2017
3
Relationship Between Amyloid Precursor Protein in Seminal Plasma and Abnormal Penile Sympathetic Skin Response in Lifelong Premature Ejaculation. ( 28065363 )
2017
4
Effects of paroxetine on intravaginal ejaculatory latency time in Egyptian patients with lifelong premature ejaculation as a function of serotonin transporter polymorphism. ( 27679962 )
2017
5
Impact of prostate volume on erectile dysfunction and premature ejaculation. ( 27145693 )
2016
6
Prevalence and Associated Factors of Premature Ejaculation in the Anhui Male Population in China: Evidence-Based Unified Definition of Lifelong and Acquired Premature Ejaculation. ( 28041923 )
2016
7
Relationship between premature ejaculation and depression: A PRISMA-compliant systematic review and meta-analysis. ( 27583879 )
2016
8
Ancient Chinese Fangzhongshu (Sexual Skills and Methods) Therapy for Premature Ejaculation. ( 28053946 )
2016
9
Premature Ejaculation and Its Remedies in Medieval Persia. ( 26827844 )
2016
10
Association of STin2 VNTR Polymorphism of Serotonin Transporter Gene with Lifelong Premature Ejaculation: A Case-Control Study in Han Chinese Subjects. ( 27713390 )
2016
11
The prevalence of premature ejaculation in young Turkish men. ( 26803992 )
2016
12
The pathophysiology of acquired premature ejaculation. ( 27652216 )
2016
13
Re: SimA/es PaAso J, Jorge Pereira B.: New Therapeutic Perspectives in Premature Ejaculation (Urology 2016; 88:87-92). A Rebuttal: Premature Ejaculation is Not a Male Sexual Dysfunction. ( 26802798 )
2016
14
The epidemiology of premature ejaculation. ( 27652213 )
2016
15
Rhodiola rosea, folic acid, zinc and biotin (EndEP(Ar)) is able to improve ejaculatory control in patients affected by lifelong premature ejaculation: Results from a phase I-II study. ( 27698696 )
2016
16
Current therapies for premature ejaculation. ( 27179987 )
2016
17
Relation of size of seminal vesicles on ultrasound to premature ejaculation. ( 27538475 )
2016
18
Premature ejaculation in type II diabetes mellitus patients: association with glycemic control. ( 27141454 )
2016
19
From the definition to the social impact of premature ejaculation. Expert consensus. ( 27908635 )
2016
20
Efficacy and safety of Qiaoshao Formula () on patients with lifelong premature ejaculation of Gan (Liver) depression and Shen (Kidney) deficiency syndrome: A randomized controlled trial. ( 27170351 )
2016
21
Surgery is not indicated for the treatment of premature ejaculation. ( 27652232 )
2016
22
Effect of Interventions for Premature Ejaculation in the Treatment of Chronic Prostatitis with Secondary Premature Ejaculation. ( 27594150 )
2016
23
Evaluating the content and quality of information about premature ejaculation on the Internet: what are men being exposed to ? ( 27135776 )
2016
24
A Prospective Randomized Controlled Study to Compare Acupuncture and Dapoxetine for the Treatment of Premature Ejaculation. ( 27049323 )
2016
25
Diagnosis and Treatment of Premature Ejaculation by Urologists in South Korea. ( 28053952 )
2016
26
Somatosensory evoked potentials assess the efficacy of circumcision for premature ejaculation. ( 27193064 )
2016
27
Biallelic and Triallelic 5-Hydroxytyramine Transporter Gene-Linked Polymorphic Region (5- HTTLPR) Polymorphisms and Their Relationship with Lifelong Premature Ejaculation: A Case-Control Study in a Chinese Population. ( 27311544 )
2016
28
On-Demand Modafinil Improves Ejaculation Time and Patient Reported Outcomes in Men with Lifelong Premature Ejaculation. ( 27151339 )
2016
29
A combination of tryptophan, Satureja montana, Tribulus terrestris, Phyllanthus emblica extracts is able to improve sexual quality of life in patient with premature ejaculation. ( 27711088 )
2016
30
Comparison of Treatment Emergent Adverse Events in Men With Premature Ejaculation Treated With Dapoxetine and Alternate Oral Treatments: Results From a Large Multinational Observational Trial. ( 26805941 )
2016
31
Psychosexual therapy for premature ejaculation. ( 27652220 )
2016
32
Event-level impact of Promescent on quality of sexual experience in men with subjective premature ejaculation. ( 27557610 )
2016
33
Understanding the Pathophysiology of Premature Ejaculation: Bridging the Link between Pharmacological and Psychological Interventions. ( 27993112 )
2016
34
Complementary and Alternative Medicine for Management of Premature Ejaculation: A Systematic Review. ( 28041925 )
2016
35
Premature ejaculation results from partners' mismatch: development and validation of index of intra-vaginal ejaculation latency time. ( 26865101 )
2016
36
Emerging and investigational drugs for premature ejaculation. ( 27652222 )
2016
37
Is there a place for surgical treatment of premature ejaculation? ( 27652223 )
2016
38
Effectiveness of 'on demand' silodosin in the treatment of premature ejaculation in patients dissatisfied with dapoxetine: a randomized control study. ( 27729995 )
2016
39
Initiators and Barriers to Discussion and Treatment of Premature Ejaculation Among Men and Their Partners in Asia Pacific - Results From a Web-based Survey. ( 27528556 )
2016
40
Patient reported outcomes in the assessment of premature ejaculation. ( 27652219 )
2016
41
Classification and definition of premature ejaculation. ( 27652214 )
2016
42
The drug treatment of premature ejaculation. ( 27652221 )
2016
43
Effects of Tadalafil 5 mg Dosed Once Daily in Men with Premature Ejaculation. ( 27160247 )
2016
44
Efficacy and safety of dapoxetine in treatment of premature ejaculation: an evidence-based review. ( 27456527 )
2016
45
The Asia-Pacific Flexible Dose Study of Dapoxetine and Patient Satisfaction in Premature Ejaculation Therapy: The PASSION Study. ( 26944775 )
2016
46
The pathophysiology of lifelong premature ejaculation. ( 27652215 )
2016
47
Assessment of hormonal activity in patients with premature ejaculation. ( 27619666 )
2016
48
Attitudes of Sexual Medicine Specialists Toward Premature Ejaculation Diagnosis and Therapy. ( 27346231 )
2016
49
The design and methodology of premature ejaculation interventional studies. ( 27652224 )
2016
50
Comparing the length of penile mucosa in men with and without premature ejaculation. ( 26812606 )
2016

Variations for Premature Ejaculation

Expression for Premature Ejaculation

Search GEO for disease gene expression data for Premature Ejaculation.

Pathways for Premature Ejaculation

GO Terms for Premature Ejaculation

Cellular components related to Premature Ejaculation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.02 HTR1A HTR1B HTR2C SLC6A3 SLC6A4
2 presynapse GO:0098793 8.96 SLC6A3 SLC6A4

Biological processes related to Premature Ejaculation according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.97 HTR1A HTR1B HTR2C LEP PDE5A
2 response to drug GO:0042493 9.73 HTR1B HTR2C SLC6A3 SLC6A4
3 cellular response to retinoic acid GO:0071300 9.58 LEP SLC6A4
4 neurotransmitter transport GO:0006836 9.56 SLC6A3 SLC6A4
5 response to ethanol GO:0045471 9.56 HTR1B HTR3A LEP SLC6A3
6 feeding behavior GO:0007631 9.55 HTR1B HTR2C
7 behavioral fear response GO:0001662 9.54 HTR1A HTR2C
8 neurotransmitter biosynthetic process GO:0042136 9.52 SLC6A3 SLC6A4
9 ammonium transmembrane transport GO:0072488 9.51 SLC6A3 SLC6A4
10 response to cocaine GO:0042220 9.5 HTR1B HTR3A SLC6A3
11 regulation of dopamine metabolic process GO:0042053 9.49 HTR1A SLC6A3
12 regulation of behavior GO:0050795 9.48 HTR1A HTR1B
13 monoamine transport GO:0015844 9.46 SLC6A3 SLC6A4
14 dopamine uptake involved in synaptic transmission GO:0051583 9.4 SLC6A3 SLC6A4
15 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0007198 9.37 HTR1A HTR1B
16 vasoconstriction GO:0042310 9.33 HTR1A HTR1B SLC6A4
17 behavior GO:0007610 9.13 HTR1A HTR1B HTR2C
18 serotonin receptor signaling pathway GO:0007210 8.8 HTR1A HTR2C HTR3A

Molecular functions related to Premature Ejaculation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transducer activity GO:0004871 9.61 HTR1A HTR1B HTR2C
2 drug binding GO:0008144 9.5 HTR1B HTR2C SLC6A3
3 neurotransmitter:sodium symporter activity GO:0005328 9.4 SLC6A3 SLC6A4
4 monoamine transmembrane transporter activity GO:0008504 9.37 SLC6A3 SLC6A4
5 neurotransmitter receptor activity GO:0030594 9.33 HTR1A HTR1B HTR2C
6 dopamine:sodium symporter activity GO:0005330 9.26 SLC6A3 SLC6A4
7 G-protein coupled serotonin receptor activity GO:0004993 9.26 HTR1A HTR1B HTR2C HTR3A
8 serotonin binding GO:0051378 8.92 HTR1A HTR1B HTR2C HTR3A

Sources for Premature Ejaculation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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