MCID: PRM013
MIFTS: 51

Premature Menopause malady

Summaries for Premature Menopause

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63Wikipedia, 32MalaCards
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Wikipedia:63 Premature Ovarian Failure (POF), also known as premature ovarian insufficiency (POI), primary ovarian... more...

MalaCards: Premature Menopause, also known as premature menopause nos, is related to premature ovarian failure and breast cancer. An important gene associated with Premature Menopause is POLG (polymerase (DNA directed), gamma), and among its related pathways are Fanconi anemia pathway and Homologous Recombination Repair. The drugs chlorotrianisene and estradiol and the compounds h2o2 and aphidicolin have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and bone, and related mouse phenotypes are skeleton and integument.

Aliases & Classifications for Premature Menopause

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8Disease Ontology, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

premature menopause 8 60
premature menopause nos 8
menopause - premature 8
menopause premature 44
menopause praecox 8


External Ids:

Disease Ontology8 DOID:10787
MeSH34 D008594
NCIt39 C80099
ICD9CM27 256.31

Related Diseases for Premature Menopause

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17GeneCards, 18GeneDecks
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Diseases related to Premature Menopause via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1premature ovarian failure30.5FSHR, TPO
2breast cancer30.4BRCA1, BRCA2
3infertility30.4TPO, FSHR, POLG
4autoimmune thyroiditis30.0TG, TPO
5polyneuropathy mental retardation acromicria premature menopause10.4
6blepharophimosis10.2
7osteoporosis10.2
8ovarian cancer10.2
9stroke, ischemic10.0
10coronary artery disease10.0
11cerebritis10.0
12amenorrhea10.0
13bone lymphoma10.0
14fragile x syndrome10.0
15mumps10.0
16gonadal dysgenesis10.0
17myasthenia gravis10.0
18polyneuropathy10.0
19thyroiditis10.0
20vascular disease10.0
21breast-ovarian cancer, familial, 210.0BRCA2
22wilms tumor10.0BRCA2
23pancreatitis10.0BRCA2
24deficiency anemia10.0BRCA1
25subacute thyroiditis10.0TG
26azoospermia10.0POLG, FSHR
27oligospermia10.0POLG, FSHR
28endometriosis10.0FSHR
29male infertility10.0POLG, FSHR
30brca1 and brca2 hereditary breast and ovarian cancer10.0BRCA2, BRCA1
31fallopian tube cancer10.0BRCA2, BRCA1
32male breast cancer10.0BRCA1, BRCA2
33familial colorectal cancer10.0BRCA2, BRCA1
34li-fraumeni syndrome10.0BRCA1, BRCA2
35cowden disease10.0BRCA1, BRCA2
36peritoneal carcinoma10.0BRCA2, BRCA1
37bilateral breast cancer10.0BRCA2, BRCA1
38dysgerminoma10.0BRCA1, BRCA2
39brain disease10.0TPO, POLG
40gynecomastia10.0BRCA2, BRCA1
41pernicious anemia10.0TPO, TG
42toxic diffuse goiter10.0TG, TPO
43endemic goiter10.0TG, TPO
44nontoxic goiter10.0TG, TPO
45plummer's disease10.0TG, TPO
46thyrotropin deficiency, isolated10.0TPO, TG
47multiple endocrine neoplasia10.0BRCA2, TG
48myxedema10.0TG, TPO
49nodular goiter10.0TG, TPO
50lynch syndrome10.0BRCA2, BRCA1

Graphical network of the top 20 diseases related to Premature Menopause:



Diseases related to premature menopause

Clinical Features for Premature Menopause

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Drugs & Therapeutics for Premature Menopause

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Premature Menopause

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Anatomical Context for Premature Menopause

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32MalaCards
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MalaCards organs/tissues related to Premature Menopause:

32
Ovary, Breast, Bone, Thyroid

Animal Models for Premature Menopause or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Premature Menopause:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.4BRCA1, BRCA2, POLG, FSHR
2MP:00107718.2BRCA1, BRCA2, POLG, FSHR
3MP:00053878.0BRCA1, BRCA2, POLG, FSHR, TPO
4MP:00036317.6TG, FSHR, POLG, BRCA2, BRCA1
5MP:00053767.5TG, TPO, FSHR, BRCA2, BRCA1
6MP:00053797.3TG, TPO, FSHR, POLG, BRCA2, BRCA1
7MP:00053977.3BRCA1, BRCA2, POLG, FSHR, TPO, TG
8MP:00053787.2BRCA1, BRCA2, POLG, FSHR, TPO, TG

Publications for Premature Menopause

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50PubMed
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Articles related to Premature Menopause:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Premature menopause. (23634337)
2013
2
Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation. (23414920)
2013
3
A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges. (22917040)
2012
4
A service evaluation of women attending the menopause/premature ovarian failure clinic of a tertiary referral centre. (22519481)
2012
5
Ovarian suppression for prevention of premature menopause and infertility: empty promise or effective therapy? (22231046)
2012
6
ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure. (22248077)
2012
7
Premature menopause is associated with increased risk of cerebral infarction in Japanese women. (20042893)
2010
8
Premature menopause linked to CVD and osteoporosis. (20408329)
2010
9
In vitro fertilisation (IVF) with donor eggs in post-menopausal women: are there differences in pregnancy outcomes in women with premature ovarian failure (POF) compared with women with physiological age-related menopause? (19847640)
2009
10
Premature menopause increases cardiovascular risk. (19811237)
2009
11
"Coming to grips" with chemotherapy-induced premature menopause. (18389434)
2008
12
Suspected premature menopause. (18403549)
2008
13
Treatment of premature menopause in breast cancer patients. (17685250)
2007
14
Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study. (16818852)
2006
15
Premature menopause in patients with BRCA1 gene mutation. (16773440)
2006
16
Reproductive and hormonal sequelae of chemotherapy in women. Premature menopause and impaired fertility can result, effects that are especially disturbing to young women. (16481857)
2006
17
Premature menopause in association with blepharophimosis, ptosis, and epicanthus inversus. (16147759)
2005
18
An update: spontaneous premature ovarian failure is not an early menopause. (15866564)
2005
19
Mechanisms of premature menopause. (16310631)
2005
20
Maintenance of ovarian function and risk of premature menopause related to cancer treatment. (15784817)
2005
21
Chromosomal abnormalities and FMR1 gene premutation in Chinese women with premature menopause. (16085940)
2005
22
Premature menopause: management challenges after the Women's Health Initiative. (16354460)
2005
23
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. (15351195)
2004
24
Multiple treatment failure in premature menopause. (15207032)
2004
25
Premature menopause and self-concept disjunctions. A case for crisis management. (12235966)
2002
26
Premature menopause. 'I feel like an alien'. (12043544)
2002
27
Infertility and premature menopause in childhood cancer survivors. (10401493)
1999
28
The idiopathic forms of premature menopause and early menopause show the same genetic pattern. (10548611)
1999
29
Social and biological predictors of early menopause: a model for premature aging. (9366808)
1997
30
Androgen serum levels in women with premature ovarian failure compared to fertile and menopausal controls. (9286728)
1997
31
A case of premature menopause in an ovulating 46,XY female patient. (8979020)
1996
32
Premature menopause and low back pain. A population-based study. (7981850)
1994
33
The case against ovarian biopsy for the diagnosis of premature menopause. (8305405)
1994
34
Ovarian biopsy for diagnosis of premature menopause. (7999703)
1994
35
Dizygous twinning and premature menopause in fragile X syndrome. (7968130)
1994
36
Risk for developing osteoporosis in untreated premature menopause. (1393775)
1992
37
Bone mineral density (BMD) in patients with lymphoma: the effects of chemotherapy, intermittent corticosteroids and premature menopause. (1398514)
1992
38
Premature menopause management. (1605764)
1992
39
Ovarian failure including menopause, premature menopause, and resistant ovarian syndrome, and hormonal replacement. (2102334)
1990
40
Premature menopause: monoclonal antibody defined T lymphocyte abnormalities and antiovarian antibodies. (2784114)
1989
41
Premature menopause: three teenage cases. (3505182)
1987
42
Comparison of bone density in amenorrheic women due to athletics, weight loss, and premature menopause. (4011070)
1985
43
Premature menopause due to a small deletion in the long arm of the X chromosome: a report of three cases and a review. (7041651)
1982
44
Premature menopause. I. Etiology. (426019)
1979
45
Premature menopause and pregnancy. (885280)
1977
46
Endocrine modifications in women with premature menopause. (610316)
1977
47
Premature menopause: a report of two cases. (4528990)
1974
48
Premature menopause in autoimmune diseases. (4178272)
1969
49
Premature menopause in autoimmune diseases. (4178628)
1969
50
Premature menopause in XO-XX-XXX-XXXXX mosaicism. (6016487)
1967

Genetic Variations for Premature Menopause

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Expression for genes affiliated with Premature Menopause

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Premature Menopause

Search GEO for disease gene expression data for Premature Menopause.

Pathways for genes affiliated with Premature Menopause

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29KEGG, 53Reactome, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Premature Menopause according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3BRCA2, BRCA1
2
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9.3BRCA2, BRCA1
39.3BRCA2, BRCA1
4
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.3BRCA2, BRCA1
5
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9.3BRCA1, BRCA2
6
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9.1TG, TPO
7
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9.1TG, TPO
8
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8.9POLG, BRCA2, BRCA1

Compounds for genes affiliated with Premature Menopause

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 2BitterDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Premature Menopause according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1h2o24410.4TPO
2aphidicolin449.7POLG, BRCA1
38-oxoguanine449.7BRCA1, BRCA2
4lycopene44 2410.7BRCA1, BRCA2
5nevirapine44 49 1111.6TG, POLG
6iodotyrosine44 2410.6TG, TPO
7diiodotyrosine449.6TPO, TG
8indole-3-carbinol449.6BRCA2, BRCA1
9perchlorate449.5TPO, TG
10sodium iodide449.5TPO, TG
11propylthiouracil44 2 1111.5TG, TPO
12gliadin449.5TG, TPO
13p005449.5TPO, BRCA1
14chromium449.5TPO, TG
15iodine44 2410.5TG, TPO
16amiodarone44 49 28 1112.4TG, TPO
17125i449.4TPO, TG
18iodide44 2410.4TG, TPO
19methylmethanesulfonate449.4BRCA2, BRCA1
20cardiolipin44 1110.4TPO, TG
21methimazole44 2 1111.3TG, TPO
22bleomycin44 1110.3BRCA2, BRCA1
23agarose449.3TPO, FSHR, BRCA1
24daidzein449.3TPO, BRCA2, BRCA1
25polyacrylamide449.3BRCA1, BRCA2, FSHR
264-hydroxytamoxifen449.2BRCA2, BRCA1
27estradiol44 11 2411.0BRCA1, BRCA2, FSHR
28ribonucleic acid449.0TG, TPO, FSHR
29guanine44 11 2411.0BRCA1, FSHR, TG
30selenium44 249.9TG, TPO, BRCA1
31adpribose448.9BRCA1, BRCA2, TG
32acetylcholine44 49 28 11 2412.9TG, TPO, FSHR
33triiodothyronine448.8TG, TPO
34steroid448.8TPO, FSHR, BRCA2, BRCA1
35oligonucleotide448.7BRCA1, BRCA2, FSHR, TPO
36adenylate448.7TG, TPO, FSHR, POLG
37paraffin448.6TG, BRCA2, BRCA1
38alanine448.5TG, FSHR, POLG, BRCA1
39glutamine448.5TG, POLG, BRCA2, BRCA1
40cisplatin44 49 59 1111.5BRCA1, BRCA2, TG
41gold448.4BRCA1, BRCA2, TPO, TG
42genistein44 28 59 2 11 2413.4BRCA1, BRCA2, TPO, TG
43cycloheximide448.4BRCA1, BRCA2, TPO, TG
44estrogen448.4TG, FSHR, BRCA2, BRCA1
45cysteine448.4TG, TPO, FSHR, BRCA1
46retinoic acid44 249.3BRCA1, BRCA2, TPO, TG
47thymidine44 249.1TG, FSHR, POLG, BRCA2, BRCA1
48testosterone44 59 11 2411.0BRCA1, BRCA2, FSHR, TPO, TG

GO Terms for genes affiliated with Premature Menopause

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16Gene Ontology
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Biological processes related to Premature Menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female gonad developmentGO:0085859.4BRCA2, FSHR
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.3BRCA2, BRCA1
3double-strand break repairGO:0063029.3BRCA2, BRCA1
4hormone biosynthetic processGO:0424469.2TG, TPO
5thyroid hormone generationGO:0065909.2TG, TPO
6double-strand break repair via homologous recombinationGO:0007249.0BRCA2, BRCA1

Molecular functions related to Premature Menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.5POLG, BRCA2

Products for genes affiliated with Premature Menopause

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Premature Menopause

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet