Premature Menopause disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Premature Menopause

Sources:
⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Premature Ovarian Failure (POF), also known as premature ovarian insufficiency (POI), primary ovarian... more...

MalaCards: Premature Menopause, also known as premature menopause nos, is related to premature ovarian failure and breast cancer. An important gene associated with Premature Menopause is POLG (polymerase (DNA directed), gamma), and among its related pathways are Fanconi anemia pathway and Homologous Recombination Repair. The drugs chlorotrianisene and estradiol and the compounds h2o2 and aphidicolin have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and bone, and related mouse phenotypes are skeleton and integument.

Aliases & Classifications for Premature Menopause

Sources:
⁸Disease Ontology, ⁶⁰UMLS, ⁴⁴Novoseek, ⁵⁶SNOMED-CT, ³⁴MeSH, ³⁹NCIt, ²⁷ICD9CM
See all sources

Aliases & Descriptions:

premature menopause ⁸ ⁶⁰

premature menopause nos ⁸

menopause - premature ⁸

menopause premature ⁴⁴

menopause praecox ⁸

External Ids:

Disease Ontology⁸ DOID:10787

MeSH³⁴ D008594

SNOMED-CT⁵⁶ 154713003, 267486007, 190544007 373717006, 237789005, 74296006, more

NCIt³⁹ C80099

ICD9CM²⁷ 256.31

UMLS⁶⁰ C0025322

Related Diseases for Premature Menopause

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Premature Menopause via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 69)

id	Related Disease	Score	Top Affiliating Genes
1	premature ovarian failure	30.5	FSHR, TPO
2	breast cancer	30.4	BRCA1, BRCA2
3	infertility	30.4	TPO, FSHR, POLG
4	autoimmune thyroiditis	30.0	TG, TPO
5	polyneuropathy mental retardation acromicria premature menopause	10.4
6	blepharophimosis	10.2
7	osteoporosis	10.2
8	ovarian cancer	10.2
9	stroke, ischemic	10.0
10	coronary artery disease	10.0
11	cerebritis	10.0
12	amenorrhea	10.0
13	bone lymphoma	10.0
14	fragile x syndrome	10.0
15	mumps	10.0
16	gonadal dysgenesis	10.0
17	myasthenia gravis	10.0
18	polyneuropathy	10.0
19	thyroiditis	10.0
20	vascular disease	10.0
21	breast-ovarian cancer, familial, 2	10.0	BRCA2
22	wilms tumor	10.0	BRCA2
23	pancreatitis	10.0	BRCA2
24	deficiency anemia	10.0	BRCA1
25	subacute thyroiditis	10.0	TG
26	azoospermia	10.0	POLG, FSHR
27	oligospermia	10.0	POLG, FSHR
28	endometriosis	10.0	FSHR
29	male infertility	10.0	POLG, FSHR
30	brca1 and brca2 hereditary breast and ovarian cancer	10.0	BRCA2, BRCA1
31	fallopian tube cancer	10.0	BRCA2, BRCA1
32	male breast cancer	10.0	BRCA1, BRCA2
33	familial colorectal cancer	10.0	BRCA2, BRCA1
34	li-fraumeni syndrome	10.0	BRCA1, BRCA2
35	cowden disease	10.0	BRCA1, BRCA2
36	peritoneal carcinoma	10.0	BRCA2, BRCA1
37	bilateral breast cancer	10.0	BRCA2, BRCA1
38	dysgerminoma	10.0	BRCA1, BRCA2
39	brain disease	10.0	TPO, POLG
40	gynecomastia	10.0	BRCA2, BRCA1
41	pernicious anemia	10.0	TPO, TG
42	toxic diffuse goiter	10.0	TG, TPO
43	endemic goiter	10.0	TG, TPO
44	nontoxic goiter	10.0	TG, TPO
45	plummer's disease	10.0	TG, TPO
46	thyrotropin deficiency, isolated	10.0	TPO, TG
47	multiple endocrine neoplasia	10.0	BRCA2, TG
48	myxedema	10.0	TG, TPO
49	nodular goiter	10.0	TG, TPO
50	lynch syndrome	10.0	BRCA2, BRCA1

Graphical network of the top 20 diseases related to Premature Menopause:

Clinical Features for Premature Menopause

Drugs & Therapeutics for Premature Menopause

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Premature Menopause

Drug clinical trials:

Search ClinicalTrials for Premature Menopause

Search NIH Clinical Center for Premature Menopause

Search CenterWatch for Premature Menopause

Inferred drug relations via UMLS⁶⁰/NDF-RT⁴⁰:

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Genetic Tests for Premature Menopause

Anatomical Context for Premature Menopause

Sources:
³²MalaCards
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MalaCards organs/tissues related to Premature Menopause:

³²

Ovary, Breast, Bone, Thyroid

Animal Models for Premature Menopause or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Premature Menopause:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	8.4	FSHR, POLG, BRCA2, BRCA1
2	integument phenotype	MP:0010771	8.2	BRCA2, POLG, FSHR, BRCA1
3	immune system phenotype	MP:0005387	8.0	BRCA2, TPO, FSHR, POLG, BRCA1
4	nervous system phenotype	MP:0003631	7.6	BRCA2, BRCA1, FSHR, POLG, TG
5	homeostasis/metabolism phenotype	MP:0005376	7.5	BRCA1, FSHR, TPO, TG, BRCA2
6	endocrine/exocrine gland phenotype	MP:0005379	7.3	BRCA1, TG, TPO, FSHR, POLG, BRCA2
7	hematopoietic system phenotype	MP:0005397	7.3	BRCA1, TG, BRCA2, POLG, FSHR, TPO
8	growth/size phenotype	MP:0005378	7.2	BRCA1, TG, TPO, FSHR, POLG, BRCA2

Publications for Premature Menopause

Sources:
⁵⁰PubMed
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Articles related to Premature Menopause:

(show top 50) (show all 116)

id	Title	Authors	Year
1	Premature menopause in young breast cancer: effects on quality of life and treatment interventions. (23819028)	Rosenberg S.M.... Partridge A.H.	2013
2	Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation. (23414920)	Finch A.... Narod S.	2013
3	Psychosocial adjustment in women with premature menopause: a cross-sectional survey. (22335389)	Mann E.... Hunter M.S.	2012
4	Premature menopause or early menopause and risk of ischemic stroke. (21993082)	Rocca W.A.... Brown R.D.	2012
5	Premature menopause and severity of coronary artery disease. (22279478)	Nasri H.... Forood A.	2011
6	Hormone replacement therapy and women with premature menopause--a cancer survivorship issue. (21561765)	King J.... Jones A.	2011
7	Premature menopause: a comprehensive understanding of psychosocial aspects. (21854296)	Deeks A.A.... Vincent A.	2011
8	Estrogen receptor-1 genetic polymorphisms for the risk of premature ovarian failure and early menopause. (20095908)	Yang J.J.... Park S.K.	2010
9	Premature menopause: exploring the experience through online communication. (19298304)	Halliday L.... Boughton M.	2009
10	Successful pregnancy with frozen embryo transfer into a gestational carrier from eggs obtained from a woman in premature menopause. (19860356)	Check J.H.... Dix E.	2009
11	HRT in premature menopause. (18796482)	Rees M.C.	2008
12	Ovulation induction and pregnancy in a woman with premature menopause following gonadotropin suppression with the gonadotropin releasing hormone antagonist, cetrorelix--a case report. (18404830)	Check J.H.... Katsoff B.	2008
13	Premature menopause: Article's recommendation of HRT is highly questionable. (18467384)	Lewars M.D.	2008
14	Treatment-related risk factors for premature menopause following Hodgkin lymphoma. (17890454)	De Bruin M.L.... van Leeuwen F.E.	2008
15	Effect of premature menopause on sexuality. (19804022)	Graziottin A.	2007
16	Do survivors of childhood cancer have increased incidence of premature menopause? (17259929)	Critchley H.O.... Wallace W.H.	2007
17	Management of premature menopause. (17448268)	Pitkin J.... Williamson J.	2007
18	Premenopausal factors influencing premature ovarian failure and early menopause. (17531410)	Chang S.H.... Park S.K.	2007
19	Reproductive and hormonal sequelae of chemotherapy in women. Premature menopause and impaired fertility can result, effects that are especially disturbing to young women. (16481857)	Knobf M.T.	2006
20	Diabetes and premature menopause: is their co-existence detrimental to the skeleton? (15757861)	Hadjidakis D.J.... Raptis S.A.	2005
21	Bilateral oophorectomy and premature menopause. (16414338)	Hendrix S.L.	2005
22	Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. (15351195)	Luoma P.... Suomalainen A.	2004
23	Sexual dysfunction in women with premature menopause. (15543028)	Graziottin A.... Basson R.	2004
24	Premature ovarian failure: frequency and risk factors among women attending a network of menopause clinics in Italy. (12504937)		2003
25	Bone density patterns after normal and premature menopause. (12697368)	Hadjidakis D.J.... Raptis S.A.	2003
26	Premature menopause raises risks of fatal adrenal condition. Early diagnosis can lead to effective treatment for women. (12420381)	Cockey C.D.	2002
27	Premature menopause: multiple disruptions between the woman's biological body experience and her lived body. (11843980)	Boughton M.A.	2002
28	Should women with premature menopause be screened for FMR-1 mutations? (11256878)	Taylor A.E.	2001
29	Possibilities of sterility therapy in a patient with a premature menopause due to an X-chromosomal anomaly - a case report. (11137332)	Nawroth F.... RAPmer T.	2000
30	Premature menopause after cancer treatment. (10352073)	Muscari Lin E.... Good B.C.	1999
31	Infertility and premature menopause in childhood cancer survivors. (10401493)	Byrne J.	1999
32	The idiopathic forms of premature menopause and early menopause show the same genetic pattern. (10548611)	Tibiletti M.G.... Crosignani P.G.	1999
33	Ovarian autoimmunity: greater frequency of autoantibodies in premature menopause and unexplained infertility than in the general population. (10075866)	Luborsky J.... Pong R.	1999
34	Androgen serum levels in women with premature ovarian failure compared to fertile and menopausal controls. (9286728)	Hartmann B.W.... Huber J.C.	1997
35	Radiation-induced premature menopause: a misconception. (7635789)	Madsen B.L.... Donaldson S.S.	1995
36	Dizygous twinning and premature menopause in fragile X syndrome. (7968130)	Turner G.... Martin N.	1994
37	Duplication in the long arm of the X-chromosome associated with spastic paraparesis and premature menopause. (8267930)	Kleczkowska A.... van den Berghe H.	1993
38	Premature menopause because of an inherited deletion in the long arm of the X-chromosome. (2001764)	Veneman T.F.... Mollevanger P.	1991
39	Premature luteinizing hormone surges in menopausal gonadotropin-stimulated cycles in monkeys: lack of initiation by progesterone. (2113486)	Burns W.N.... Schenken R.S.	1990
40	Lymphocyte abnormalities in premature menopause. (2116332)	Castilla J.A.... Molina R.	1990
41	What is premature menopause? (2594794)		1989
42	Premature menopause: three teenage cases. (3505182)	Dunham A.	1987
43	Ovulation after treatment with ethinyl-oestradiol and medroxyprogesterone acetate in a woman approaching premature menopause. Case report. (3096369)	Petsos P.... Anderson D.C.	1986
44	Vascular disease risk factors in women with premature menopause. (7390402)	Carlton M.... Gibson J.C.	1980
45	Premature menopause: a reversible entity? (224354)	Szlachter B.N.... Weiss G.	1979
46	A 5/X chromosomal translocation in a patient with premature menopause. (874310)	Garcia J.E.... Rary J.M.	1977
47	Premature menopause and aortoiliac occlusive disease. (5029950)	Weiss N.S.	1972
48	Hereditary polyneuropathy, oligophrenia, premature menopause and acromicria. A new syndrome. (5117105)	Lundberg P.O.	1971
49	Early premature menopause. A report of 6 cases with cytogenetic findings. (5951624)	Baramki T.A.... Jones H.W.	1966
50	Granulosa-cell tumor of the ovary; report of five cases with premature menopause (amenorrhea) and the recurrence of menstruation. (21023761)	RHOADS E.E.	1946

Genes related to Premature Menopause

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Premature Menopause:

id	Symbol	Description	Score	Implication
1	POLG	polymerase (DNA directed), gamma	21.72	GeneCards inferred : Publications, Disorders (show sections)
2	FSHR	follicle stimulating hormone receptor	18.39	GeneCards inferred : Publications, Disorders (show sections)
3	TPO	thyroid peroxidase	15.05	GeneCards inferred : Publications, Disorders (show sections)
4	BRCA1	breast cancer 1, early onset	11.72	GeneCards inferred : Publications, Disorders (show sections)
5	TG	thyroglobulin	8.39	GeneCards inferred : Publications, Disorders (show sections)
6	BRCA2	breast cancer 2, early onset	3.07	GeneCards inferred : Publications (show sections)

Products for genes related to Premature Menopause disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	5	5	6
2	LSBio	-	-	6

Genetic Variations for Premature Menopause

Expression for genes affiliated with Premature Menopause

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Premature Menopause

Search GEO for disease gene expression data for Premature Menopause.

Pathways for genes affiliated with Premature Menopause

Sources:
²⁹KEGG, ⁵³Reactome, ⁵¹QIAGEN, ¹²EMD Millipore, ³⁷NCBI BioSystems Database
See all sources

Pathways related to Premature Menopause according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Fanconi anemia pathway²⁹	9.3	BRCA2, BRCA1
2	Homologous Recombination Repair⁵³ Hide members Homologous recombination repair of replication-independent double-strand breaks⁵³ Double-Strand Break Repair⁵³	9.3	BRCA2, BRCA1
3	BRCA1 Pathway⁵¹	9.3	BRCA2, BRCA1
4	DNA damage Role of Brca1 and Brca2 in DNA repair Hide members DNA damage Role of Brca1 and Brca2 in DNA repair¹²	9.3	BRCA2, BRCA1
5	Fanconi Anemia pathway⁵³ Hide members Fanconis Anaemia Pathway⁵¹ BARD1 signaling events³⁷	9.3	BRCA1, BRCA2
6	Allograft rejection²⁹ Hide members Autoimmune thyroid disease²⁹	9.1	TG, TPO
7	Insulin secretion²⁹ Hide members Thyroid hormone synthesis²⁹	9.1	TG, TPO
8	Chks in Checkpoint Regulation⁵¹ Hide members DNA Repair Mechanisms⁵¹	8.9	POLG, BRCA2, BRCA1

Compounds for genes affiliated with Premature Menopause

Sources:
⁴⁴Novoseek, ²⁴HMDB, ⁴⁹PharmGKB, ¹¹DrugBank, ²BitterDB, ²⁸IUPHAR, ⁵⁹Tocris Bioscience
See all sources

Compounds related to Premature Menopause according to GeneCards/GeneDecks:

(show all 48)

id	Compound	Score	Top Affiliating Genes
1	h2o2⁴⁴	10.4	TPO
2	aphidicolin⁴⁴	9.7	POLG, BRCA1
3	8-oxoguanine⁴⁴	9.7	BRCA1, BRCA2
4	lycopene⁴⁴ ²⁴	10.7	BRCA1, BRCA2
5	nevirapine⁴⁴ ⁴⁹ ¹¹	11.6	TG, POLG
6	iodotyrosine⁴⁴ ²⁴	10.6	TG, TPO
7	diiodotyrosine⁴⁴	9.6	TPO, TG
8	indole-3-carbinol⁴⁴	9.6	BRCA2, BRCA1
9	perchlorate⁴⁴	9.5	TPO, TG
10	sodium iodide⁴⁴	9.5	TPO, TG
11	propylthiouracil⁴⁴ ² ¹¹	11.5	TG, TPO
12	gliadin⁴⁴	9.5	TG, TPO
13	p005⁴⁴	9.5	TPO, BRCA1
14	chromium⁴⁴	9.5	TPO, TG
15	iodine⁴⁴ ²⁴	10.5	TG, TPO
16	amiodarone⁴⁴ ⁴⁹ ²⁸ ¹¹	12.4	TG, TPO
17	125i⁴⁴	9.4	TPO, TG
18	iodide⁴⁴ ²⁴	10.4	TG, TPO
19	methylmethanesulfonate⁴⁴	9.4	BRCA2, BRCA1
20	cardiolipin⁴⁴ ¹¹	10.4	TPO, TG
21	methimazole⁴⁴ ² ¹¹	11.3	TG, TPO
22	bleomycin⁴⁴ ¹¹	10.3	BRCA2, BRCA1
23	agarose⁴⁴	9.3	TPO, FSHR, BRCA1
24	daidzein⁴⁴	9.3	TPO, BRCA2, BRCA1
25	polyacrylamide⁴⁴	9.3	BRCA1, BRCA2, FSHR
26	4-hydroxytamoxifen⁴⁴	9.2	BRCA2, BRCA1
27	estradiol⁴⁴ ¹¹ ²⁴	11.0	BRCA1, BRCA2, FSHR
28	ribonucleic acid⁴⁴	9.0	TG, TPO, FSHR
29	guanine⁴⁴ ¹¹ ²⁴	11.0	BRCA1, FSHR, TG
30	selenium⁴⁴ ²⁴	9.9	TG, TPO, BRCA1
31	adpribose⁴⁴	8.9	BRCA1, BRCA2, TG
32	acetylcholine⁴⁴ ⁴⁹ ²⁸ ¹¹ ²⁴	12.9	TG, TPO, FSHR
33	triiodothyronine⁴⁴	8.8	TG, TPO
34	steroid⁴⁴	8.8	TPO, FSHR, BRCA2, BRCA1
35	oligonucleotide⁴⁴	8.7	BRCA1, BRCA2, FSHR, TPO
36	adenylate⁴⁴	8.7	TG, TPO, FSHR, POLG
37	paraffin⁴⁴	8.6	TG, BRCA2, BRCA1
38	alanine⁴⁴	8.5	TG, FSHR, POLG, BRCA1
39	glutamine⁴⁴	8.5	TG, POLG, BRCA2, BRCA1
40	cisplatin⁴⁴ ⁴⁹ ⁵⁹ ¹¹	11.5	BRCA1, BRCA2, TG
41	gold⁴⁴	8.4	BRCA1, BRCA2, TPO, TG
42	genistein⁴⁴ ²⁸ ⁵⁹ ² ¹¹ ²⁴	13.4	BRCA1, BRCA2, TPO, TG
43	cycloheximide⁴⁴	8.4	BRCA1, BRCA2, TPO, TG
44	estrogen⁴⁴	8.4	TG, FSHR, BRCA2, BRCA1
45	cysteine⁴⁴	8.4	TG, TPO, FSHR, BRCA1
46	retinoic acid⁴⁴ ²⁴	9.3	BRCA1, BRCA2, TPO, TG
47	thymidine⁴⁴ ²⁴	9.1	TG, FSHR, POLG, BRCA2, BRCA1
48	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	11.0	BRCA1, BRCA2, FSHR, TPO, TG

GO Terms for genes affiliated with Premature Menopause

Sources:
¹⁶Gene Ontology
See all sources

Biological processes related to Premature Menopause according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	female gonad development	GO:008585	9.4	BRCA2, FSHR
2	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:006978	9.3	BRCA2, BRCA1
3	double-strand break repair	GO:006302	9.3	BRCA2, BRCA1
4	hormone biosynthetic process	GO:042446	9.2	TG, TPO
5	thyroid hormone generation	GO:006590	9.2	TG, TPO
6	double-strand break repair via homologous recombination	GO:000724	9.0	BRCA2, BRCA1