MCID: PRM013
MIFTS: 54

Premature Menopause malady

Reproductive diseases category
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Summaries for Premature Menopause

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Wikipedia:65 Premature Ovarian Failure (POF), also known as premature ovarian insufficiency (POI), primary ovarian... more...

MalaCards based summary: Premature Menopause, also known as premature menopause nos, is related to premature ovarian failure and breast cancer. An important gene associated with Premature Menopause is POLG (polymerase (DNA directed), gamma), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. The drugs angelica sinensis preparation and chlorotrianisene and the compounds nevirapine and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and bone, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Premature Menopause

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH
See all sources

Premature Menopause, Aliases & Descriptions:

Name: Premature Menopause 8 62
Premature Menopause Nos 8
Menopause - Premature 8
 
Menopause Premature 44
Menopause Praecox 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:10787
ICD9CM27 256.31
NCIt39 C80099
MeSH34 D008594

Related Diseases for Premature Menopause

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Diseases related to Premature Menopause via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1premature ovarian failure30.9FSHR, TPO
2breast cancer30.7BRCA2, BRCA1
3infertility30.6TPO, POLG, FSHR
4thyroiditis30.4TPO, TG
5hodgkin's lymphoma30.1BRCA1, BRCA2
6polyneuropathy mental retardation acromicria premature menopause10.5
7breast-ovarian cancer, familial, 110.3BRCA2
8oligospermia10.3FSHR, POLG
9male infertility10.2FSHR, POLG
10blepharophimosis10.2
11oophoritis10.2
12polyneuropathy - intellectual disability - acromicria - premature menopause10.2
13subacute thyroiditis10.2TG, TPO
14pernicious anemia10.2TG, TPO
15toxic diffuse goiter10.2TPO, TG
16endemic goiter10.2TPO, TG
17plummer's disease10.2TG, TPO
18nontoxic goiter10.2TG, TPO
19multinodular goiter10.2TPO, TG
20thyrotropin deficiency, isolated10.2TPO, TG
21hypogonadism10.2FSHR, POLG
22myxedema10.2TPO, TG
23thyrotoxicosis10.2TG, TPO
24azoospermia10.2FSHR, POLG
25nodular goiter10.2TPO, TG
26pendred syndrome10.2TG, TPO
27hypothyroidism10.2TG, TPO
28cystadenoma10.2FSHR, BRCA1
29follicular thyroid carcinoma10.2TPO, TG
30turner syndrome10.2TPO, TG
31congenital hypothyroidism10.2TPO, TG
32pregnancy loss10.2TPO, TG
33thyroid adenoma10.2TG, TPO
34thyroid cancer, anaplastic10.2TPO, TG
35goiter10.2TPO, TG
36brain disease10.2POLG, TPO
37addison's disease10.2TPO, TG
38follicular adenoma10.1TPO, TG
39autoimmune thyroiditis10.1TG, TPO
40celiac disease10.1TG, TPO
41papillary thyroid carcinoma10.1TPO, TG
42myasthenia gravis10.1
43osteoporosis10.1
44fragile x syndrome10.1
45amenorrhea10.1
46mumps10.1
47cerebritis10.1
48artery disease10.1
49gonadal dysgenesis10.1
50polyneuropathy10.1

Graphical network of the top 20 diseases related to Premature Menopause:



Diseases related to premature menopause

Symptoms for Premature Menopause

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Drugs & Therapeutics for Premature Menopause

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Genetic Tests for Premature Menopause

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Anatomical Context for Premature Menopause

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MalaCards organs/tissues related to Premature Menopause:

32
Ovary, Breast, Bone, Thyroid

Animal Models for Premature Menopause or affiliated genes

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MGI Mouse Phenotypes related to Premature Menopause:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0FSHR, BRCA1, POLG
2MP:00020068.3FSHR, BRCA1, BRCA2, POLG
3MP:00053718.2TPO, BRCA2, BRCA1, FSHR
4MP:00107718.2POLG, BRCA2, BRCA1, FSHR
5MP:00053898.1FSHR, BRCA1, BRCA2, POLG
6MP:00053907.8TPO, POLG, BRCA2, BRCA1, FSHR
7MP:00053877.8TPO, POLG, BRCA2, BRCA1, FSHR
8MP:00036317.7FSHR, BRCA1, BRCA2, POLG, TG
9MP:00053797.4FSHR, BRCA1, BRCA2, POLG, TG, TPO
10MP:00053977.4TPO, TG, POLG, BRCA2, BRCA1, FSHR
11MP:00053787.4TPO, TG, POLG, BRCA2, BRCA1, FSHR
12MP:00107687.3TPO, POLG, BRCA2, BRCA1, FSHR
13MP:00053767.3TPO, TG, POLG, BRCA2, BRCA1, FSHR

Publications for Premature Menopause

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Articles related to Premature Menopause:

(show top 50)    (show all 110)
idTitleAuthorsYear
1
Premature menopause - Meeting the needs. (24879744)
2014
2
An interpretive description of chemotherapy-induced premature menopause among Latinas with breast cancer. (25158665)
2014
3
Risk of premature menopause after treatment for Hodgkin's lymphoma. (25139687)
2014
4
Premature menopause in young breast cancer: effects on quality of life and treatment interventions. (23819028)
2013
5
Psychosocial adjustment in women with premature menopause: a cross-sectional survey. (22335389)
2012
6
A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges. (22917040)
2012
7
Premature menopause and severity of coronary artery disease. (22279478)
2011
8
Menopause and sexuality: key issues in premature menopause and beyond. (20840281)
2010
9
Premature menopause is associated with increased risk of cerebral infarction in Japanese women. (20042893)
2010
10
Premature menopause: exploring the experience through online communication. (19298304)
2009
11
HRT in premature menopause. (18796482)
2008
12
Premature menopause: Hormone replacement therapy is indeed indicated. (18497386)
2008
13
"Coming to grips" with chemotherapy-induced premature menopause. (18389434)
2008
14
Treatment of premature menopause in breast cancer patients. (17685250)
2007
15
Effect of premature menopause on sexuality. (19804022)
2007
16
Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study. (16818852)
2006
17
Premature menopause in association with blepharophimosis, ptosis, and epicanthus inversus. (16147759)
2005
18
Mechanisms of premature menopause. (16310631)
2005
19
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. (15351195)
2004
20
Multiple treatment failure in premature menopause. (15207032)
2004
21
Premature menopause in a multi-ethnic population study of the menopause transition. (12525467)
2003
22
Premature menopause and self-concept disjunctions. A case for crisis management. (12235966)
2002
23
Should women with premature menopause be screened for FMR-1 mutations? (11256878)
2001
24
Premature menopause after cancer treatment. (10352073)
1999
25
Infertility and premature menopause in childhood cancer survivors. (10401493)
1999
26
The risk of premature menopause induced by chemotherapy for early breast cancer. (10534297)
1999
27
The impact of premature menopause on women's experience of self. (10818847)
1999
28
The idiopathic forms of premature menopause and early menopause show the same genetic pattern. (10548611)
1999
29
A case of premature menopause in an ovulating 46,XY female patient. (8979020)
1996
30
Radiation-induced premature menopause: a misconception. (7635789)
1995
31
Ovarian biopsy for diagnosis of premature menopause. (7999704)
1994
32
Duplication in the long arm of the X-chromosome associated with spastic paraparesis and premature menopause. (8267930)
1993
33
Risk for developing osteoporosis in untreated premature menopause. (1393775)
1992
34
Premature menopause because of an inherited deletion in the long arm of the X-chromosome. (2001764)
1991
35
What is premature menopause? (2594794)
1989
36
Premature menopause: monoclonal antibody defined T lymphocyte abnormalities and antiovarian antibodies. (2784114)
1989
37
Premature menopause. (3502933)
1987
38
Premature menopause: three teenage cases. (3505182)
1987
39
Premature menopause due to a small deletion in the long arm of the X chromosome: a report of three cases and a review. (7041651)
1982
40
Myasthenia gravis, premature menopause, and thyroid autoimmunity. (7405986)
1980
41
Identification of differing etiologies of clinically diagnosed premature menopause. (463997)
1979
42
Premature menopause: a reversible entity? (224354)
1979
43
Premature menopause. I. Etiology. (426019)
1979
44
A 5/X chromosomal translocation in a patient with premature menopause. (874310)
1977
45
Premature menopause and aortoiliac occlusive disease. (5029950)
1972
46
Hereditary polyneuropathy, oligophrenia, premature menopause and acromicria. A new syndrome. (5117105)
1971
47
Premature menopause. A clinical, histologic, and cytogenetic study. (5410380)
1970
48
Premature menopause in autoimmune diseases. (4178272)
1969
49
Premature menopause in XO-XX-XXX-XXXXX mosaicism. (6016487)
1967
50
Early premature menopause. A report of 6 cases with cytogenetic findings. (5951624)
1966

Variations for Premature Menopause

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Expression for genes affiliated with Premature Menopause

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Expression patterns in normal tissues for genes affiliated with Premature Menopause

Search GEO for disease gene expression data for Premature Menopause.

Pathways for genes affiliated with Premature Menopause

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Pathways related to Premature Menopause according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TG, TPO
2
Show member pathways
9.4TG, TPO
3
Show member pathways
9.0BRCA1, BRCA2
4
Show member pathways
9.0BRCA2, BRCA1
5
Show member pathways
9.0BRCA1, BRCA2
69.0BRCA2, BRCA1
7
Show member pathways
9.0BRCA2, BRCA1
8
Show member pathways
9.0BRCA1, BRCA2
99.0BRCA1, BRCA2
10
Show member pathways
8.6BRCA1, BRCA2, POLG

Compounds for genes affiliated with Premature Menopause

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Compounds related to Premature Menopause according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1nevirapine44 50 1111.9TG, POLG
2iodotyrosine44 2410.9TPO, TG
3diiodotyrosine449.9TG, TPO
4perchlorate449.9TG, TPO
5sodium iodide449.8TG, TPO
6propylthiouracil44 2 1111.8TG, TPO
7gliadin449.8TG, TPO
8chromium449.8TPO, TG
9iodine44 2410.8TG, TPO
10amiodarone44 50 28 1112.7TG, TPO
11125i449.7TG, TPO
12aphidicolin449.7BRCA1, POLG
13iodide44 2410.7TPO, TG
14cardiolipin44 1110.7TPO, TG
15methimazole44 2 1111.6TG, TPO
16p005449.5BRCA1, TPO
178-oxoguanine449.4BRCA2, BRCA1
18lycopene44 2410.4BRCA1, BRCA2
19ribonucleic acid449.3FSHR, TG, TPO
20acetylcholine44 50 28 24 1113.3TPO, TG, FSHR
21agarose449.3FSHR, BRCA1, TPO
22guanine44 24 1111.3FSHR, BRCA1, TG
23indole-3-carbinol449.3BRCA1, BRCA2
24selenium44 2410.3BRCA1, TG, TPO
25methylmethanesulfonate449.2BRCA2, BRCA1
26triiodothyronine449.1TG, TPO
274-hydroxytamoxifen449.0BRCA2, BRCA1
28bleomycin44 1110.0BRCA1, BRCA2
29adenylate449.0TPO, TG, POLG, FSHR
30polyacrylamide449.0BRCA2, BRCA1, FSHR
31daidzein449.0TPO, BRCA2, BRCA1
32adpribose448.9BRCA1, BRCA2, TG
33alanine448.9TG, POLG, BRCA1, FSHR
34estradiol44 24 1110.8BRCA2, BRCA1, FSHR
35paraffin448.8BRCA1, BRCA2, TG
36cysteine448.7TPO, TG, BRCA1, FSHR
37cisplatin44 50 61 1111.6BRCA1, BRCA2, TG
38glutamine448.5TG, POLG, BRCA2, BRCA1
39progesterone44 28 61 24 1112.5FSHR, BRCA1, BRCA2
40steroid448.5TPO, BRCA2, BRCA1, FSHR
41oligonucleotide448.5TPO, BRCA2, BRCA1, FSHR
42gold448.4TPO, TG, BRCA2, BRCA1
43estrogen448.4FSHR, BRCA1, BRCA2, TG
44genistein44 28 61 2 24 1113.4TPO, TG, BRCA2, BRCA1
45tyrosine448.4FSHR, BRCA1, TG, TPO
46cycloheximide448.4BRCA1, BRCA2, TG, TPO
47h2o2448.4TPO, TG, BRCA2, BRCA1
48retinoic acid44 249.4TPO, TG, BRCA2, BRCA1
49thymidine44 249.1FSHR, BRCA1, BRCA2, POLG, TG
50testosterone44 61 24 1111.0FSHR, BRCA1, BRCA2, TG, TPO

GO Terms for genes affiliated with Premature Menopause

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Biological processes related to Premature Menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.5TG, TPO
2thyroid hormone generationGO:0065909.5TG, TPO
3female gonad developmentGO:0085859.1BRCA2, FSHR
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.0BRCA1, BRCA2
5double-strand break repairGO:0063029.0BRCA1, BRCA2
6double-strand break repair via homologous recombinationGO:0007248.7BRCA1, BRCA2

Molecular functions related to Premature Menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2BRCA2, POLG

Products for genes affiliated with Premature Menopause

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  • Antibodies
  • Proteins
  • Lysates

Sources for Premature Menopause

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet