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MCID: PRM013

Premature Menopause malady
21 drugs, 5 genes, 1 tissue, 37 related diseases, clinical trials.

Summaries for Premature Menopause

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59Wikipedia, 29MalaCards
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Wikipedia:59 Premature Ovarian Failure (POF), also known as premature ovarian insufficiency, primary ovarian... more...

MalaCards: Premature Menopause, also known as premature menopause nos, is related to premature ovarian failure and infertility. An important gene associated with Premature Menopause is POLG (polymerase (DNA directed), gamma). The drugs estrogens and dong quai and the compounds nevirapine and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include ovary and ovary, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Aliases & Classifications for Premature Menopause

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8Disease Ontology, 41Novoseek, 56UMLS, 31MeSH, 52SNOMED-CT, 25ICD9CM, 36NCIt
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Aliases & Descriptions:

premature menopause 8
premature menopause nos 8
menopause - premature 8
menopause, premature 56
menopause premature 41
menopause praecox 8



External Ids:

Disease Ontology8 DOID:10787
ICD9CM25 256.31

Related Diseases for Premature Menopause

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16GeneCards, 17GeneDecks
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Diseases related to premature menopause via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1premature ovarian failure30.6FSHR, TPO
2infertility27.9POLG, FSHR, TPO
3subacute thyroiditis13.3TG
4thyrotoxicosis13.2TG
5oligospermia12.8POLG, FSHR
6megaloblastic anemia12.7TG, TPO
7toxic diffuse goiter12.7TPO, TG
8nontoxic goiter12.7TG, TPO
9plummer's disease12.7TPO, TG
10endemic goiter12.7TG, TPO
11thyrotropin deficiency, isolated12.7TG, TPO
12male infertility12.7FSHR, POLG
13myxedema12.7TPO, TG
14pendred syndrome12.7TG, TPO
15nodular goiter12.7TPO, TG
16follicular thyroid carcinoma12.7TPO, TG
17turner syndrome12.7TPO, TG
18thyroid cancer12.7TPO, TG
19sycp3-related pregnancy loss, susceptibility to12.6TG, TPO
20multinodular goiter12.6TPO, TG
21thyroid cancer, anaplastic12.6TPO, TG
22follicular adenoma12.5TG, TPO
23autoimmune thyroiditis12.5TPO, TG
24congenital hypothyroidism12.5TPO, TG
25aicardi-goutieres syndrome12.5POLG, TPO
26thyroid adenoma12.4TPO, TG
27nonencapsulated sclerosing carcinoma12.3TPO, TG
28addison's disease12.3TPO, TG
29li-fraumeni syndrome12.3TPO, BRCA1
30papillary thyroid carcinoma12.2TPO, TG
31hyperthyroidism12.2TG, FSHR, TPO
32hypothyroidism12.2FSHR, TPO, TG
33ovarian cancer12.0BRCA1, FSHR, TG
34thyroid medullary carcinoma11.9BRCA1, TPO, TG
35cystadenoma11.8BRCA1, FSHR
36adenoma11.3TPO, BRCA1, FSHR, TG
37polyneuropathy mental retardation acromicria premature menopause8.8

Graphical network of the top 20 diseases related to premature menopause:



Diseases related to premature menopause

Symptoms for Premature Menopause

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Drugs & Therapeutics for Premature Menopause

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Sources:
5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials, 56UMLS, 37NDF-RT
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Approved drugs:

Search CenterWatch for premature menopause

Drug clinical trials:

Search ClinicalTrials for premature menopause

Search NIH Clinical Center for premature menopause

Search CenterWatch for premature menopause

Inferred drug relations via UMLS56/NDF-RT37:

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Genetic Tests for Premature Menopause

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Anatomical Context for Premature Menopause

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29MalaCards
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MalaCards organs/tissues related to premature menopause:

29
Ovary

Animal Models for Premature Menopause or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to premature menopause:

33
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
adipose tissue phenotype
MP:00053758.7BRCA1, FSHR, POLG
2
endocrine/exocrine gland phenotype
MP:00053797.5BRCA1, FSHR, TPO, TG, POLG
3
hematopoietic system phenotype
MP:00053977.4POLG, TG, TPO, FSHR, BRCA1
4
growth/size phenotype
MP:00053787.2POLG, TG, TPO, FSHR, BRCA1

Publications for Premature Menopause

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47PubMed
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Articles related to premature menopause:

idTitleAuthorsYearAffiliating Genes
1Ovulation induction and pregnancy in a woman with premature menopause following gonadotropin suppression with the gonadotropin releasing hormone antagonist, cetrorelix--a case report. (18404830)Check J.H.... Katsoff B.2008FSHR
2Premature menopause in patients with BRCA1 gene mutation. (16773440)Rzepka-Gorska I.... Tol/oczko-Grabarek A.2006BRCA1
3Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. (15351195)Luoma P.... Suomalainen A.2004POLG
4Ovarian autoimmunity: greater frequency of autoantibodies in premature menopause and unexplained infertility than in the general population. (10075866)Luborsky J.... Pong R.1999TPO, TG

Variations for Premature Menopause

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Expression for genes affiliated with Premature Menopause

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Premature Menopause

Pathways for genes affiliated with Premature Menopause

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Compounds for genes affiliated with Premature Menopause

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41Novoseek, 46PharmGKB, 11DrugBank, 22HMDB, 2BitterDB
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Compounds related to premature menopause according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1nevirapine41 46 1111.9TG, POLG
2iodotyrosine41 2210.8TPO, TG
3diiodotyrosine419.7TPO, TG
4perchlorate419.7TPO, TG
5sodium iodide419.7TPO, TG
6propylthiouracil41 2 1111.7TPO, TG
7gliadin419.7TG, TPO
8chromium419.7TG, TPO
9iodine41 2210.7TG, TPO
10amiodarone41 46 1111.7TG, TPO
11125i419.6TPO, TG
12iodide41 2210.6TPO, TG
13cardiolipin41 1110.6TPO, TG
14methimazole41 2 1111.6TG, TPO
15triiodothyronine419.5TPO, TG
16aphidicolin419.5BRCA1, POLG
17daidzein419.4TPO, BRCA1
18p005419.3BRCA1, TPO
19asparagine419.2TPO, FSHR
20ribonucleic acid419.2FSHR, TPO, TG
21suramin41 1110.1FSHR, TG
22adpribose419.1BRCA1, TG
23acetylcholine41 11 2211.1TG, TPO, FSHR
24guanine41 11 2211.0TG, FSHR, BRCA1
25selenium41 229.9TG, TPO, BRCA1
26gold418.9TG, TPO, BRCA1
27agarose418.9TPO, FSHR, BRCA1
28glutamine418.9BRCA1, TG, POLG
29adenylate418.8POLG, TG, TPO, FSHR
30genistein41 2 11 2211.7TG, TPO, BRCA1
31cycloheximide418.7TG, TPO, BRCA1
32h2o2418.6BRCA1, TPO, TG
33thymidine41 229.6BRCA1, FSHR, TG, POLG
34alanine418.5BRCA1, FSHR, TG, POLG
35steroid418.5BRCA1, FSHR, TPO
36testosterone41 11 2210.4BRCA1, FSHR, TPO, TG
37cysteine418.3BRCA1, FSHR, TPO, TG
38tyrosine418.1TG, TPO, FSHR, BRCA1

GO Terms for genes affiliated with Premature Menopause

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15Gene Ontology
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Biological processes related to premature menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:0065909.3TPO, TG
2hormone biosynthetic processGO:0424469.0TPO, TG

Products for genes affiliated with Premature Menopause

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  • Antibodies
  • Proteins
  • Lysates

Sources for Premature Menopause

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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