MCID: PRM013
MIFTS: 54

Premature Menopause malady

Reproductive diseases category
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Summaries for Premature Menopause

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65Wikipedia, 33MalaCards
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Wikipedia:65 Premature Ovarian Failure (POF), also known as premature ovarian insufficiency (POI), primary ovarian... more...

MalaCards: Premature Menopause, also known as premature menopause nos, is related to premature ovarian failure and breast cancer. An important gene associated with Premature Menopause is POLG (polymerase (DNA directed), gamma), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. The drugs chlorotrianisene and estradiol and the compounds nevirapine and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and bone, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Premature Menopause

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8Disease Ontology, 62UMLS, 45Novoseek, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

premature menopause 8 62
premature menopause nos 8
menopause - premature 8
menopause premature 45
menopause praecox 8


External Ids:

Disease Ontology8 DOID:10787
NCIt40 C80099
MeSH35 D008594
ICD9CM27 256.31

Related Diseases for Premature Menopause

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Premature Menopause via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1premature ovarian failure30.6FSHR, TPO
2breast cancer30.6BRCA2, BRCA1
3infertility30.5FSHR, POLG, TPO
4thyroiditis30.2TPO, TG
5polyneuropathy mental retardation acromicria premature menopause10.5
6blepharophimosis10.2
7osteoporosis10.2
8oophoritis10.2
9polyneuropathy - intellectual disability - acromicria - premature menopause10.2
10breast-ovarian cancer, familial, 210.1BRCA2
11coronary artery disease10.1
12mumps10.1
13cerebritis10.1
14amenorrhea10.1
15fragile x syndrome10.1
16artery disease10.1
17gonadal dysgenesis10.1
18myasthenia gravis10.1
19polyneuropathy10.1
20vascular disease10.1
21autoimmune oophoritis10.1
22granulosa cell tumor of the ovary10.1
23spastic paraparesis10.1
24back pain10.1
25spasticity10.1
26oligospermia10.1POLG, FSHR
27male infertility10.1POLG, FSHR
28pernicious anemia10.1TPO, TG
29subacute thyroiditis10.0TG, TPO
30toxic diffuse goiter10.0TPO, TG
31endemic goiter10.0TPO, TG
32nontoxic goiter10.0TPO, TG
33plummer's disease10.0TG, TPO
34multinodular goiter10.0TPO, TG
35myxedema10.0TG, TPO
36hypogonadism10.0FSHR, POLG
37thyrotropin deficiency, isolated10.0TPO, TG
38thyrotoxicosis10.0TPO, TG
39azoospermia10.0POLG, FSHR
40nodular goiter10.0TPO, TG
41pendred syndrome10.0TG, TPO
42hypothyroidism10.0TG, TPO
43cystadenoma10.0BRCA1, FSHR
44follicular thyroid carcinoma10.0TG, TPO
45turner syndrome10.0TPO, TG
46congenital hypothyroidism10.0TG, TPO
47pregnancy loss10.0TG, TPO
48thyroid adenoma10.0TG, TPO
49goiter10.0TG, TPO
50thyroid cancer, anaplastic10.0TPO, TG

Graphical network of the top 20 diseases related to Premature Menopause:



Diseases related to premature menopause

Symptoms for Premature Menopause

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Drugs & Therapeutics for Premature Menopause

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Premature Menopause

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Anatomical Context for Premature Menopause

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33MalaCards
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MalaCards organs/tissues related to Premature Menopause:

33
Ovary, Breast, Bone, Thyroid

Animal Models for Premature Menopause or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Premature Menopause:

37 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0POLG, FSHR, BRCA1
2MP:00020068.3POLG, BRCA1, FSHR, BRCA2
3MP:00053718.2BRCA1, BRCA2, FSHR, TPO
4MP:00107718.2BRCA2, FSHR, BRCA1, POLG
5MP:00053898.1FSHR, BRCA1, BRCA2, POLG
6MP:00053907.8POLG, BRCA2, BRCA1, FSHR, TPO
7MP:00053877.8POLG, BRCA1, BRCA2, FSHR, TPO
8MP:00036317.7FSHR, BRCA2, POLG, TG, BRCA1
9MP:00053797.4FSHR, BRCA2, POLG, TG, TPO, BRCA1
10MP:00053977.4FSHR, TPO, TG, POLG, BRCA2, BRCA1
11MP:00053787.4FSHR, BRCA1, POLG, BRCA2, TPO, TG
12MP:00107687.3TPO, POLG, BRCA2, BRCA1, FSHR
13MP:00053767.3FSHR, BRCA2, POLG, TG, TPO, BRCA1

Publications for Premature Menopause

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Sources:
52PubMed
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Articles related to Premature Menopause:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Premature menopause in young breast cancer: effects on quality of life and treatment interventions. (23819028)
2013
2
Psychosocial adjustment in women with premature menopause: a cross-sectional survey. (22335389)
2012
3
A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges. (22917040)
2012
4
Premature menopause and severity of coronary artery disease. (22279478)
2011
5
Menopause and sexuality: key issues in premature menopause and beyond. (20840281)
2010
6
Premature menopause is associated with increased risk of cerebral infarction in Japanese women. (20042893)
2010
7
Premature menopause linked to CVD and osteoporosis. (20408329)
2010
8
Premature menopause: exploring the experience through online communication. (19298304)
2009
9
HRT in premature menopause. (18796482)
2008
10
Premature menopause: Hormone replacement therapy is indeed indicated. (18497386)
2008
11
"Coming to grips" with chemotherapy-induced premature menopause. (18389434)
2008
12
Treatment of premature menopause in breast cancer patients. (17685250)
2007
13
Effect of premature menopause on sexuality. (19804022)
2007
14
Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study. (16818852)
2006
15
Premature menopause in association with blepharophimosis, ptosis, and epicanthus inversus. (16147759)
2005
16
Mechanisms of premature menopause. (16310631)
2005
17
Diabetes and premature menopause: is their co-existence detrimental to the skeleton? (15757861)
2005
18
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. (15351195)
2004
19
Multiple treatment failure in premature menopause. (15207032)
2004
20
Premature menopause in a multi-ethnic population study of the menopause transition. (12525467)
2003
21
Premature menopause and self-concept disjunctions. A case for crisis management. (12235966)
2002
22
Should women with premature menopause be screened for FMR-1 mutations? (11256878)
2001
23
Premature menopause: a multidisciplinary approach whurr. (22049459)
2001
24
Premature menopause after cancer treatment. (10352073)
1999
25
Infertility and premature menopause in childhood cancer survivors. (10401493)
1999
26
The risk of premature menopause induced by chemotherapy for early breast cancer. (10534297)
1999
27
The impact of premature menopause on women's experience of self. (10818847)
1999
28
The idiopathic forms of premature menopause and early menopause show the same genetic pattern. (10548611)
1999
29
A case of premature menopause in an ovulating 46,XY female patient. (8979020)
1996
30
Radiation-induced premature menopause: a misconception. (7635789)
1995
31
Ovarian biopsy for diagnosis of premature menopause. (7999704)
1994
32
Duplication in the long arm of the X-chromosome associated with spastic paraparesis and premature menopause. (8267930)
1993
33
Risk for developing osteoporosis in untreated premature menopause. (1393775)
1992
34
Premature menopause because of an inherited deletion in the long arm of the X-chromosome. (2001764)
1991
35
What is premature menopause? (2594794)
1989
36
Premature menopause: monoclonal antibody defined T lymphocyte abnormalities and antiovarian antibodies. (2784114)
1989
37
Premature menopause. (3502933)
1987
38
Premature menopause: three teenage cases. (3505182)
1987
39
Premature menopause due to a small deletion in the long arm of the X chromosome: a report of three cases and a review. (7041651)
1982
40
Myasthenia gravis, premature menopause, and thyroid autoimmunity. (7405986)
1980
41
Identification of differing etiologies of clinically diagnosed premature menopause. (463997)
1979
42
Premature menopause: a reversible entity? (224354)
1979
43
Premature menopause. I. Etiology. (426019)
1979
44
A 5/X chromosomal translocation in a patient with premature menopause. (874310)
1977
45
Premature menopause and aortoiliac occlusive disease. (5029950)
1972
46
Hereditary polyneuropathy, oligophrenia, premature menopause and acromicria. A new syndrome. (5117105)
1971
47
Premature menopause. A clinical, histologic, and cytogenetic study. (5410380)
1970
48
Premature menopause in autoimmune diseases. (4178272)
1969
49
Premature menopause in XO-XX-XXX-XXXXX mosaicism. (6016487)
1967
50
Early premature menopause. A report of 6 cases with cytogenetic findings. (5951624)
1966

Variations for Premature Menopause

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Expression for genes affiliated with Premature Menopause

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Premature Menopause

Search GEO for disease gene expression data for Premature Menopause.

Pathways for genes affiliated with Premature Menopause

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 12EMD Millipore, 53QIAGEN, 60Thomson Reuters
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Pathways related to Premature Menopause according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TG, TPO
2
Show member pathways
9.4TG, TPO
3
Show member pathways
9.0BRCA1, BRCA2
4
Show member pathways
9.0BRCA2, BRCA1
5
Show member pathways
9.0BRCA1, BRCA2
69.0BRCA2, BRCA1
7
Show member pathways
9.0BRCA2, BRCA1
8
Show member pathways
9.0BRCA1, BRCA2
99.0BRCA1, BRCA2
10
Show member pathways
8.6BRCA1, BRCA2, POLG

Compounds for genes affiliated with Premature Menopause

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Premature Menopause according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1nevirapine45 51 1111.9POLG, TG
2iodotyrosine45 2410.9TPO, TG
3diiodotyrosine459.9TPO, TG
4perchlorate459.9TG, TPO
5sodium iodide459.8TG, TPO
6propylthiouracil45 3 1111.8TPO, TG
7gliadin459.8TPO, TG
8chromium459.8TG, TPO
9iodine45 2410.8TPO, TG
10amiodarone45 51 29 1112.7TPO, TG
11125i459.7TPO, TG
12aphidicolin459.7BRCA1, POLG
13iodide45 2410.7TG, TPO
14cardiolipin45 1110.7TPO, TG
15methimazole45 3 1111.6TPO, TG
16p005459.5TPO, BRCA1
178-oxoguanine459.4BRCA1, BRCA2
18lycopene45 2410.4BRCA1, BRCA2
19ribonucleic acid459.3FSHR, TG, TPO
20acetylcholine45 51 29 24 1113.3TPO, FSHR, TG
21agarose459.3TPO, BRCA1, FSHR
22guanine45 24 1111.3FSHR, TG, BRCA1
23indole-3-carbinol459.3BRCA2, BRCA1
24selenium45 2410.3TG, BRCA1, TPO
25methylmethanesulfonate459.2BRCA2, BRCA1
26triiodothyronine459.1TPO, TG
274-hydroxytamoxifen459.0BRCA2, BRCA1
28bleomycin45 1110.0BRCA1, BRCA2
29adenylate459.0TPO, TG, POLG, FSHR
30polyacrylamide459.0FSHR, BRCA1, BRCA2
31daidzein459.0BRCA1, TPO, BRCA2
32adpribose458.9BRCA1, TG, BRCA2
33alanine458.9BRCA1, FSHR, POLG, TG
34estradiol45 24 1110.8BRCA1, FSHR, BRCA2
35paraffin458.8BRCA1, BRCA2, TG
36cysteine458.7TG, TPO, FSHR, BRCA1
37cisplatin45 51 61 1111.6BRCA1, BRCA2, TG
38glutamine458.5TG, POLG, BRCA2, BRCA1
39progesterone45 29 61 24 1112.5FSHR, BRCA1, BRCA2
40steroid458.5TPO, BRCA2, BRCA1, FSHR
41oligonucleotide458.5BRCA1, FSHR, BRCA2, TPO
42gold458.4TG, TPO, BRCA1, BRCA2
43estrogen458.4BRCA1, TG, FSHR, BRCA2
44genistein45 29 61 3 24 1113.4TG, TPO, BRCA1, BRCA2
45tyrosine458.4TPO, FSHR, TG, BRCA1
46cycloheximide458.4TG, BRCA1, BRCA2, TPO
47h2o2458.4TPO, TG, BRCA2, BRCA1
48retinoic acid45 249.4TG, TPO, BRCA2, BRCA1
49thymidine45 249.1TG, FSHR, BRCA1, BRCA2, POLG
50testosterone45 61 24 1111.0FSHR, BRCA1, BRCA2, TPO, TG

GO Terms for genes affiliated with Premature Menopause

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16Gene Ontology
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Biological processes related to Premature Menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.5TG, TPO
2thyroid hormone generationGO:0065909.5TG, TPO
3female gonad developmentGO:0085859.1BRCA2, FSHR
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.0BRCA1, BRCA2
5double-strand break repairGO:0063029.0BRCA1, BRCA2
6double-strand break repair via homologous recombinationGO:0007248.7BRCA1, BRCA2

Molecular functions related to Premature Menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.2BRCA2, POLG

Products for genes affiliated with Premature Menopause

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Premature Menopause

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet