MCID: PRM013
MIFTS: 47

Premature Menopause malady

Summaries for Premature Menopause

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MalaCards based summary: Premature Menopause, also known as premature menopause nos, is related to premature ovarian failure and breast cancer. An important gene associated with Premature Menopause is POLG (polymerase (DNA directed), gamma), and among its related pathways are Thyroxine (Thyroid Hormone) Production and Insulin secretion. The drugs chlorotrianisene and estradiol and the compounds nevirapine and iodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and ovary, and related mouse phenotypes are adipose tissue and tumorigenesis.

Aliases & Classifications for Premature Menopause

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 38NCIt
See all sources

Premature Menopause, Aliases & Descriptions:

Name: Premature Menopause 9 60
Premature Menopause Nos 9
Menopause - Premature 9
 
Menopause Premature 43
Menopause Praecox 9


External Ids:

Disease Ontology9 DOID:10787
MeSH33 D008594
ICD9CM27 256.31
NCIt38 C80099

Related Diseases for Premature Menopause

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Diseases related to Premature Menopause via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1premature ovarian failure31.0FSHR, TPO
2breast cancer30.7BRCA1, BRCA2
3infertility30.5FSHR, POLG, TPO
4thyroiditis30.4TPO, TG
5hodgkin lymphoma29.9BRCA2, BRCA1
6polyneuropathy mental retardation acromicria premature menopause10.6
7hereditary breast ovarian cancer10.3BRCA2
8oligospermia10.3POLG, FSHR
9osteoporosis10.2
10blepharophimosis10.2
11oophoritis10.2
12male infertility10.2POLG, FSHR
13goiter, multinodular 1, with or without sertoli-leydig cell tumors10.2TG, TPO
14pernicious anemia10.2TPO, TG
15subacute thyroiditis10.2TG, TPO
16toxic diffuse goiter10.2TPO, TG
17endemic goiter10.2TPO, TG
18nontoxic goiter10.2TPO, TG
19plummer's disease10.2TG, TPO
20multinodular goiter10.2TPO, TG
21hypogonadism10.2FSHR, POLG
22myxedema10.2TG, TPO
23hypothryoidism, congenital, nongoitrous 410.2TPO, TG
24autoimmune thyroiditis10.2TPO, TG
25azoospermia10.2POLG, FSHR
26thyrotoxicosis10.2TPO, TG
27nodular goiter10.2TPO, TG
28pendred syndrome10.2TG, TPO
29hypothyroidism10.2TG, TPO
30cystadenoma10.2BRCA1, FSHR
31thyroid carcinoma, follicular10.2TG, TPO
32turner syndrome10.2TPO, TG
33congenital hypothyroidism10.2TG, TPO
34thyroid adenoma10.2TG, TPO
35goiter10.2TG, TPO
36thyroid cancer, anaplastic10.2TPO, TG
37brain disease10.1TPO, POLG
38addison's disease10.1TG, TPO
39follicular adenoma10.1TG, TPO
40hashimoto thyroiditis10.1TG, TPO
41celiac disease10.1TPO, TG
42thyroid carcinoma, papillary10.1TG, TPO
43coronary artery disease10.1
44fragile x syndrome10.1
45myasthenia gravis10.1
46mumps10.1
47cerebritis10.1
48amenorrhea10.1
49artery disease10.1
50gonadal dysgenesis10.1

Graphical network of the top 20 diseases related to Premature Menopause:



Diseases related to premature menopause

Symptoms for Premature Menopause

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Drugs & Therapeutics for Premature Menopause

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Genetic Tests for Premature Menopause

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Anatomical Context for Premature Menopause

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MalaCards organs/tissues related to Premature Menopause:

31
Breast, Bone, Ovary, Thyroid

Animal Models for Premature Menopause or affiliated genes

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MGI Mouse Phenotypes related to Premature Menopause:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0POLG, FSHR, BRCA1
2MP:00020068.3POLG, BRCA1, FSHR, BRCA2
3MP:00053718.2BRCA1, BRCA2, FSHR, TPO
4MP:00107718.2BRCA2, FSHR, BRCA1, POLG
5MP:00053898.1FSHR, BRCA1, BRCA2, POLG
6MP:00053907.8POLG, BRCA2, BRCA1, FSHR, TPO
7MP:00053877.8POLG, BRCA1, BRCA2, FSHR, TPO
8MP:00036317.7FSHR, BRCA2, POLG, TG, BRCA1
9MP:00053797.4FSHR, BRCA2, POLG, TG, TPO, BRCA1
10MP:00053977.4FSHR, TPO, TG, POLG, BRCA2, BRCA1
11MP:00053787.4FSHR, BRCA1, POLG, BRCA2, TPO, TG
12MP:00107687.3TPO, POLG, BRCA2, BRCA1, FSHR
13MP:00053767.3FSHR, BRCA2, POLG, TG, TPO, BRCA1

Publications for Premature Menopause

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Articles related to Premature Menopause:

(show top 50)    (show all 111)
idTitleAuthorsYear
1
Premature menopause - Meeting the needs. (24879744)
2014
2
An interpretive description of chemotherapy-induced premature menopause among Latinas with breast cancer. (25158665)
2014
3
Risk of premature menopause after treatment for Hodgkin's lymphoma. (25139687)
2014
4
Premature menopause in young breast cancer: effects on quality of life and treatment interventions. (23819028)
2013
5
Psychosocial adjustment in women with premature menopause: a cross-sectional survey. (22335389)
2012
6
A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges. (22917040)
2012
7
Premature menopause and severity of coronary artery disease. (22279478)
2011
8
Menopause and sexuality: key issues in premature menopause and beyond. (20840281)
2010
9
Premature menopause is associated with increased risk of cerebral infarction in Japanese women. (20042893)
2010
10
Premature menopause linked to CVD and osteoporosis. (20408329)
2010
11
Premature menopause: exploring the experience through online communication. (19298304)
2009
12
HRT in premature menopause. (18796482)
2008
13
Premature menopause: Hormone replacement therapy is indeed indicated. (18497386)
2008
14
"Coming to grips" with chemotherapy-induced premature menopause. (18389434)
2008
15
Treatment of premature menopause in breast cancer patients. (17685250)
2007
16
Effect of premature menopause on sexuality. (19804022)
2007
17
Premature menopause in survivors of childhood cancer: a report from the childhood cancer survivor study. (16818852)
2006
18
Premature menopause in association with blepharophimosis, ptosis, and epicanthus inversus. (16147759)
2005
19
Mechanisms of premature menopause. (16310631)
2005
20
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. (15351195)
2004
21
Multiple treatment failure in premature menopause. (15207032)
2004
22
Premature menopause and self-concept disjunctions. A case for crisis management. (12235966)
2002
23
Should women with premature menopause be screened for FMR-1 mutations? (11256878)
2001
24
Premature menopause after cancer treatment. (10352073)
1999
25
Infertility and premature menopause in childhood cancer survivors. (10401493)
1999
26
The risk of premature menopause induced by chemotherapy for early breast cancer. (10534297)
1999
27
The impact of premature menopause on women's experience of self. (10818847)
1999
28
The idiopathic forms of premature menopause and early menopause show the same genetic pattern. (10548611)
1999
29
A case of premature menopause in an ovulating 46,XY female patient. (8979020)
1996
30
Radiation-induced premature menopause: a misconception. (7635789)
1995
31
Ovarian biopsy for diagnosis of premature menopause. (7999704)
1994
32
Duplication in the long arm of the X-chromosome associated with spastic paraparesis and premature menopause. (8267930)
1993
33
Risk for developing osteoporosis in untreated premature menopause. (1393775)
1992
34
Premature menopause because of an inherited deletion in the long arm of the X-chromosome. (2001764)
1991
35
What is premature menopause? (2594794)
1989
36
Premature menopause: monoclonal antibody defined T lymphocyte abnormalities and antiovarian antibodies. (2784114)
1989
37
Premature menopause. (3502933)
1987
38
Premature menopause: three teenage cases. (3505182)
1987
39
Premature menopause due to a small deletion in the long arm of the X chromosome: a report of three cases and a review. (7041651)
1982
40
Myasthenia gravis, premature menopause, and thyroid autoimmunity. (7405986)
1980
41
Identification of differing etiologies of clinically diagnosed premature menopause. (463997)
1979
42
Premature menopause: a reversible entity? (224354)
1979
43
Premature menopause. I. Etiology. (426019)
1979
44
A 5/X chromosomal translocation in a patient with premature menopause. (874310)
1977
45
Premature menopause and aortoiliac occlusive disease. (5029950)
1972
46
Hereditary polyneuropathy, oligophrenia, premature menopause and acromicria. A new syndrome. (5117105)
1971
47
Premature menopause. A clinical, histologic, and cytogenetic study. (5410380)
1970
48
Premature menopause in autoimmune diseases. (4178272)
1969
49
Premature menopause in XO-XX-XXX-XXXXX mosaicism. (6016487)
1967
50
Early premature menopause. A report of 6 cases with cytogenetic findings. (5951624)
1966

Variations for Premature Menopause

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Expression for genes affiliated with Premature Menopause

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Search GEO for disease gene expression data for Premature Menopause.

Pathways for genes affiliated with Premature Menopause

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Pathways related to Premature Menopause according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TPO, TG
2
Show member pathways
9.4TPO, TG
3
Show member pathways
9.0BRCA1, BRCA2
4
Show member pathways
9.0BRCA2, BRCA1
59.0BRCA1, BRCA2
6
Show member pathways
9.0BRCA2, BRCA1
7
Show member pathways
9.0BRCA2, BRCA1
89.0BRCA2, BRCA1
9
Show member pathways
8.6BRCA1, BRCA2, POLG

Compounds for genes affiliated with Premature Menopause

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Compounds related to Premature Menopause according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1nevirapine43 49 1211.9TG, POLG
2iodotyrosine43 2410.9TPO, TG
3diiodotyrosine439.9TG, TPO
4perchlorate439.9TG, TPO
5sodium iodide439.8TG, TPO
6propylthiouracil43 2 1211.8TG, TPO
7gliadin439.8TG, TPO
8chromium439.8TPO, TG
9iodine43 2410.8TG, TPO
10amiodarone43 49 28 1212.7TG, TPO
11125i439.7TG, TPO
12aphidicolin439.7BRCA1, POLG
13iodide43 2410.7TPO, TG
14cardiolipin43 1210.7TPO, TG
15methimazole43 2 1211.6TG, TPO
16p005439.5BRCA1, TPO
178-oxoguanine439.4BRCA2, BRCA1
18lycopene43 2410.4BRCA1, BRCA2
19ribonucleic acid439.3FSHR, TG, TPO
20acetylcholine43 49 28 24 1213.3TPO, TG, FSHR
21agarose439.3FSHR, BRCA1, TPO
22guanine43 24 1211.3FSHR, BRCA1, TG
23indole-3-carbinol439.3BRCA1, BRCA2
24selenium43 2410.3BRCA1, TG, TPO
25methylmethanesulfonate439.2BRCA2, BRCA1
26triiodothyronine439.1TG, TPO
274-hydroxytamoxifen439.0BRCA2, BRCA1
28bleomycin43 1210.0BRCA1, BRCA2
29adenylate439.0TPO, TG, POLG, FSHR
30polyacrylamide439.0BRCA2, BRCA1, FSHR
31daidzein439.0TPO, BRCA2, BRCA1
32adpribose438.9BRCA1, BRCA2, TG
33alanine438.9TG, POLG, BRCA1, FSHR
34estradiol43 24 1210.8BRCA2, BRCA1, FSHR
35paraffin438.8BRCA1, BRCA2, TG
36cysteine438.7TPO, TG, BRCA1, FSHR
37cisplatin43 49 59 1211.6BRCA1, BRCA2, TG
38glutamine438.5TG, POLG, BRCA2, BRCA1
39progesterone43 28 59 24 1212.5FSHR, BRCA1, BRCA2
40steroid438.5TPO, BRCA2, BRCA1, FSHR
41oligonucleotide438.5TPO, BRCA2, BRCA1, FSHR
42gold438.4TPO, TG, BRCA2, BRCA1
43estrogen438.4FSHR, BRCA1, BRCA2, TG
44genistein43 28 59 2 24 1213.4TPO, TG, BRCA2, BRCA1
45tyrosine438.4FSHR, BRCA1, TG, TPO
46cycloheximide438.4BRCA1, BRCA2, TG, TPO
47h2o2438.4TPO, TG, BRCA2, BRCA1
48retinoic acid43 249.4TPO, TG, BRCA2, BRCA1
49thymidine43 249.1FSHR, BRCA1, BRCA2, POLG, TG
50testosterone43 59 24 1211.0FSHR, BRCA1, BRCA2, TG, TPO

GO Terms for genes affiliated with Premature Menopause

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Biological processes related to Premature Menopause according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:00424469.5TG, TPO
2thyroid hormone generationGO:00065909.5TG, TPO
3female gonad developmentGO:00085859.1BRCA2, FSHR
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.0BRCA1, BRCA2
5double-strand break repairGO:00063029.0BRCA1, BRCA2
6double-strand break repair via homologous recombinationGO:00007248.7BRCA1, BRCA2

Molecular functions related to Premature Menopause according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.2BRCA2, POLG

Products for genes affiliated with Premature Menopause

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Sources for Premature Menopause

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet