MCID: PRM013
MIFTS: 51

Premature Menopause malady

Summaries for Premature Menopause

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63Wikipedia, 32MalaCards
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Wikipedia:63 Premature Ovarian Failure (POF), also known as premature ovarian insufficiency (POI), primary ovarian... more...

MalaCards: Premature Menopause, also known as premature menopause nos, is related to premature ovarian failure and breast cancer. An important gene associated with Premature Menopause is POLG (polymerase (DNA directed), gamma), and among its related pathways are Fanconi anemia pathway and Homologous Recombination Repair. The drugs chlorotrianisene and estradiol and the compounds h2o2 and aphidicolin have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and bone, and related mouse phenotypes are skeleton and integument.

Aliases & Classifications for Premature Menopause

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8Disease Ontology, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

premature menopause 8 60
premature menopause nos 8
menopause - premature 8
menopause premature 44
menopause praecox 8


External Ids:

Disease Ontology8 DOID:10787
MeSH34 D008594
NCIt39 C80099
ICD9CM27 256.31

Related Diseases for Premature Menopause

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17GeneCards, 18GeneDecks
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Diseases related to Premature Menopause via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1premature ovarian failure30.5FSHR, TPO
2breast cancer30.4BRCA1, BRCA2
3infertility30.4TPO, FSHR, POLG
4autoimmune thyroiditis30.0TG, TPO
5polyneuropathy mental retardation acromicria premature menopause10.4
6blepharophimosis10.2
7osteoporosis10.2
8ovarian cancer10.2
9stroke, ischemic10.0
10coronary artery disease10.0
11cerebritis10.0
12amenorrhea10.0
13bone lymphoma10.0
14fragile x syndrome10.0
15mumps10.0
16gonadal dysgenesis10.0
17myasthenia gravis10.0
18polyneuropathy10.0
19thyroiditis10.0
20vascular disease10.0
21breast-ovarian cancer, familial, 210.0BRCA2
22wilms tumor10.0BRCA2
23pancreatitis10.0BRCA2
24deficiency anemia10.0BRCA1
25subacute thyroiditis10.0TG
26azoospermia10.0POLG, FSHR
27oligospermia10.0POLG, FSHR
28endometriosis10.0FSHR
29male infertility10.0POLG, FSHR
30brca1 and brca2 hereditary breast and ovarian cancer10.0BRCA2, BRCA1
31fallopian tube cancer10.0BRCA2, BRCA1
32male breast cancer10.0BRCA1, BRCA2
33familial colorectal cancer10.0BRCA2, BRCA1
34li-fraumeni syndrome10.0BRCA1, BRCA2
35cowden disease10.0BRCA1, BRCA2
36peritoneal carcinoma10.0BRCA2, BRCA1
37bilateral breast cancer10.0BRCA2, BRCA1
38dysgerminoma10.0BRCA1, BRCA2
39brain disease10.0TPO, POLG
40gynecomastia10.0BRCA2, BRCA1
41pernicious anemia10.0TPO, TG
42toxic diffuse goiter10.0TG, TPO
43endemic goiter10.0TG, TPO
44nontoxic goiter10.0TG, TPO
45plummer's disease10.0TG, TPO
46thyrotropin deficiency, isolated10.0TPO, TG
47multiple endocrine neoplasia10.0BRCA2, TG
48myxedema10.0TG, TPO
49nodular goiter10.0TG, TPO
50lynch syndrome10.0BRCA2, BRCA1

Graphical network of the top 20 diseases related to Premature Menopause:



Diseases related to premature menopause

Clinical Features for Premature Menopause

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Drugs & Therapeutics for Premature Menopause

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Premature Menopause

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Anatomical Context for Premature Menopause

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32MalaCards
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MalaCards organs/tissues related to Premature Menopause:

32
Ovary, Breast, Bone, Thyroid

Animal Models for Premature Menopause or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Premature Menopause:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.4FSHR, POLG, BRCA2, BRCA1
2MP:00107718.2BRCA2, POLG, FSHR, BRCA1
3MP:00053878.0BRCA2, TPO, FSHR, POLG, BRCA1
4MP:00036317.6BRCA2, BRCA1, FSHR, POLG, TG
5MP:00053767.5BRCA1, FSHR, TPO, TG, BRCA2
6MP:00053797.3BRCA1, TG, TPO, FSHR, POLG, BRCA2
7MP:00053977.3BRCA1, TG, BRCA2, POLG, FSHR, TPO
8MP:00053787.2BRCA1, TG, TPO, FSHR, POLG, BRCA2

Publications for Premature Menopause

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50PubMed
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Articles related to Premature Menopause:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Premature menopause in young breast cancer: effects on quality of life and treatment interventions. (23819028)
2013
2
Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation. (23414920)
2013
3
Psychosocial adjustment in women with premature menopause: a cross-sectional survey. (22335389)
2012
4
Premature menopause or early menopause and risk of ischemic stroke. (21993082)
2012
5
Premature menopause and severity of coronary artery disease. (22279478)
2011
6
Hormone replacement therapy and women with premature menopause--a cancer survivorship issue. (21561765)
2011
7
Premature menopause: a comprehensive understanding of psychosocial aspects. (21854296)
2011
8
Estrogen receptor-1 genetic polymorphisms for the risk of premature ovarian failure and early menopause. (20095908)
2010
9
Premature menopause: exploring the experience through online communication. (19298304)
2009
10
Successful pregnancy with frozen embryo transfer into a gestational carrier from eggs obtained from a woman in premature menopause. (19860356)
2009
11
HRT in premature menopause. (18796482)
2008
12
Ovulation induction and pregnancy in a woman with premature menopause following gonadotropin suppression with the gonadotropin releasing hormone antagonist, cetrorelix--a case report. (18404830)
2008
13
Premature menopause: Article's recommendation of HRT is highly questionable. (18467384)
2008
14
Treatment-related risk factors for premature menopause following Hodgkin lymphoma. (17890454)
2008
15
Effect of premature menopause on sexuality. (19804022)
2007
16
Do survivors of childhood cancer have increased incidence of premature menopause? (17259929)
2007
17
Management of premature menopause. (17448268)
2007
18
Premenopausal factors influencing premature ovarian failure and early menopause. (17531410)
2007
19
Reproductive and hormonal sequelae of chemotherapy in women. Premature menopause and impaired fertility can result, effects that are especially disturbing to young women. (16481857)
2006
20
Diabetes and premature menopause: is their co-existence detrimental to the skeleton? (15757861)
2005
21
Bilateral oophorectomy and premature menopause. (16414338)
2005
22
Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. (15351195)
2004
23
Sexual dysfunction in women with premature menopause. (15543028)
2004
24
Premature ovarian failure: frequency and risk factors among women attending a network of menopause clinics in Italy. (12504937)
2003
25
Bone density patterns after normal and premature menopause. (12697368)
2003
26
Premature menopause raises risks of fatal adrenal condition. Early diagnosis can lead to effective treatment for women. (12420381)
2002
27
Premature menopause: multiple disruptions between the woman's biological body experience and her lived body. (11843980)
2002
28
Should women with premature menopause be screened for FMR-1 mutations? (11256878)
2001
29
Possibilities of sterility therapy in a patient with a premature menopause due to an X-chromosomal anomaly - a case report. (11137332)
2000
30
Premature menopause after cancer treatment. (10352073)
1999
31
Infertility and premature menopause in childhood cancer survivors. (10401493)
1999
32
The idiopathic forms of premature menopause and early menopause show the same genetic pattern. (10548611)
1999
33
Ovarian autoimmunity: greater frequency of autoantibodies in premature menopause and unexplained infertility than in the general population. (10075866)
1999
34
Androgen serum levels in women with premature ovarian failure compared to fertile and menopausal controls. (9286728)
1997
35
Radiation-induced premature menopause: a misconception. (7635789)
1995
36
Dizygous twinning and premature menopause in fragile X syndrome. (7968130)
1994
37
Duplication in the long arm of the X-chromosome associated with spastic paraparesis and premature menopause. (8267930)
1993
38
Premature menopause because of an inherited deletion in the long arm of the X-chromosome. (2001764)
1991
39
Premature luteinizing hormone surges in menopausal gonadotropin-stimulated cycles in monkeys: lack of initiation by progesterone. (2113486)
1990
40
Lymphocyte abnormalities in premature menopause. (2116332)
1990
41
What is premature menopause? (2594794)
1989
42
Premature menopause: three teenage cases. (3505182)
1987
43
Ovulation after treatment with ethinyl-oestradiol and medroxyprogesterone acetate in a woman approaching premature menopause. Case report. (3096369)
1986
44
Vascular disease risk factors in women with premature menopause. (7390402)
1980
45
Premature menopause: a reversible entity? (224354)
1979
46
A 5/X chromosomal translocation in a patient with premature menopause. (874310)
1977
47
Premature menopause and aortoiliac occlusive disease. (5029950)
1972
48
Hereditary polyneuropathy, oligophrenia, premature menopause and acromicria. A new syndrome. (5117105)
1971
49
Early premature menopause. A report of 6 cases with cytogenetic findings. (5951624)
1966
50
Granulosa-cell tumor of the ovary; report of five cases with premature menopause (amenorrhea) and the recurrence of menstruation. (21023761)
1946

Genetic Variations for Premature Menopause

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Expression for genes affiliated with Premature Menopause

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Premature Menopause

Search GEO for disease gene expression data for Premature Menopause.

Pathways for genes affiliated with Premature Menopause

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29KEGG, 53Reactome, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Premature Menopause according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3BRCA2, BRCA1
2
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9.3BRCA2, BRCA1
39.3BRCA2, BRCA1
4
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.3BRCA2, BRCA1
5
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9.3BRCA1, BRCA2
6
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9.1TG, TPO
7
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9.1TG, TPO
8
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8.9POLG, BRCA2, BRCA1

Compounds for genes affiliated with Premature Menopause

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 2BitterDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Premature Menopause according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1h2o24410.4TPO
2aphidicolin449.7POLG, BRCA1
38-oxoguanine449.7BRCA1, BRCA2
4lycopene44 2410.7BRCA1, BRCA2
5nevirapine44 49 1111.6TG, POLG
6iodotyrosine44 2410.6TG, TPO
7diiodotyrosine449.6TPO, TG
8indole-3-carbinol449.6BRCA2, BRCA1
9perchlorate449.5TPO, TG
10sodium iodide449.5TPO, TG
11propylthiouracil44 2 1111.5TG, TPO
12gliadin449.5TG, TPO
13p005449.5TPO, BRCA1
14chromium449.5TPO, TG
15iodine44 2410.5TG, TPO
16amiodarone44 49 28 1112.4TG, TPO
17125i449.4TPO, TG
18iodide44 2410.4TG, TPO
19methylmethanesulfonate449.4BRCA2, BRCA1
20cardiolipin44 1110.4TPO, TG
21methimazole44 2 1111.3TG, TPO
22bleomycin44 1110.3BRCA2, BRCA1
23agarose449.3TPO, FSHR, BRCA1
24daidzein449.3TPO, BRCA2, BRCA1
25polyacrylamide449.3BRCA1, BRCA2, FSHR
264-hydroxytamoxifen449.2BRCA2, BRCA1
27estradiol44 11 2411.0BRCA1, BRCA2, FSHR
28ribonucleic acid449.0TG, TPO, FSHR
29guanine44 11 2411.0BRCA1, FSHR, TG
30selenium44 249.9TG, TPO, BRCA1
31adpribose448.9BRCA1, BRCA2, TG
32acetylcholine44 49 28 11 2412.9TG, TPO, FSHR
33triiodothyronine448.8TG, TPO
34steroid448.8TPO, FSHR, BRCA2, BRCA1
35oligonucleotide448.7BRCA1, BRCA2, FSHR, TPO
36adenylate448.7TG, TPO, FSHR, POLG
37paraffin448.6TG, BRCA2, BRCA1
38alanine448.5TG, FSHR, POLG, BRCA1
39glutamine448.5TG, POLG, BRCA2, BRCA1
40cisplatin44 49 59 1111.5BRCA1, BRCA2, TG
41gold448.4BRCA1, BRCA2, TPO, TG
42genistein44 28 59 2 11 2413.4BRCA1, BRCA2, TPO, TG
43cycloheximide448.4BRCA1, BRCA2, TPO, TG
44estrogen448.4TG, FSHR, BRCA2, BRCA1
45cysteine448.4TG, TPO, FSHR, BRCA1
46retinoic acid44 249.3BRCA1, BRCA2, TPO, TG
47thymidine44 249.1TG, FSHR, POLG, BRCA2, BRCA1
48testosterone44 59 11 2411.0BRCA1, BRCA2, FSHR, TPO, TG

GO Terms for genes affiliated with Premature Menopause

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16Gene Ontology
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Biological processes related to Premature Menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female gonad developmentGO:0085859.4BRCA2, FSHR
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.3BRCA2, BRCA1
3double-strand break repairGO:0063029.3BRCA2, BRCA1
4hormone biosynthetic processGO:0424469.2TG, TPO
5thyroid hormone generationGO:0065909.2TG, TPO
6double-strand break repair via homologous recombinationGO:0007249.0BRCA2, BRCA1

Molecular functions related to Premature Menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.5POLG, BRCA2

Products for genes affiliated with Premature Menopause

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Premature Menopause

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet