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MCID: PRM013
MIFTS: 49

Premature Menopause malady
20 drugs, 6 genes, 4 tissues, 68 related diseases, clinical trials.

Summaries for Premature Menopause

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64Wikipedia, 33MalaCards
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Wikipedia:64 Premature Ovarian Failure (POF), also known as premature ovarian insufficiency, primary ovarian... more...

MalaCards: Premature Menopause, also known as premature menopause nos, is related to premature ovarian failure and infertility. An important gene associated with Premature Menopause is POLG (polymerase (DNA directed), gamma), and among its related pathways are Fanconi anemia pathway and Homologous Recombination Repair. The drugs chlorotrianisene and estradiol and the compounds h2o2 and aphidicolin have been mentioned in the context of this disorder. Affiliated tissues include ovary, thyroid and breast, and related mouse phenotypes are skeleton and integument.

Aliases & Classifications for Premature Menopause

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8Disease Ontology, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM
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Aliases & Descriptions:

premature menopause 8 61
premature menopause nos 8
menopause - premature 8
menopause premature 45
menopause praecox 8


External Ids:

Disease Ontology8 DOID:10787
MeSH35 D008594
NCIt40 C80099
ICD9CM27 256.31

Related Diseases for Premature Menopause

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17GeneCards, 18GeneDecks
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Diseases related to Premature Menopause via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1premature ovarian failure30.6FSHR, TPO
2infertility30.4TPO, FSHR, POLG
3polyneuropathy mental retardation acromicria premature menopause10.5
4blepharophimosis10.2
5osteoporosis10.2
6oophoritis10.2
7stroke, ischemic10.1
8coronary artery disease,10.1
9amenorrhea10.1
10bone lymphoma10.1
11mumps10.1
12vascular disease10.1
13autoimmune oophoritis10.1
14ovarian cancer, childhood10.1
15spastic paraparesis10.1
16back pain10.1
17breast-ovarian cancer, familial, 210.0BRCA2
18wilms tumor10.0BRCA2
19pancreatitis10.0BRCA2
20deficiency anemia10.0BRCA1
21subacute thyroiditis10.0TG
22azoospermia10.0POLG, FSHR
23oligospermia10.0POLG, FSHR
24endometriosis10.0FSHR
25male infertility10.0POLG, FSHR
26brca1 and brca2 hereditary breast and ovarian cancer10.0BRCA2, BRCA1
27fallopian tube cancer10.0BRCA2, BRCA1
28male breast cancer10.0BRCA1, BRCA2
29familial colorectal cancer10.0BRCA2, BRCA1
30breast cancer10.0BRCA1, BRCA2
31li-fraumeni syndrome10.0BRCA1, BRCA2
32cowden disease10.0BRCA1, BRCA2
33peritoneal carcinoma10.0BRCA2, BRCA1
34bilateral breast cancer10.0BRCA2, BRCA1
35dysgerminoma10.0BRCA1, BRCA2
36brain disease10.0TPO, POLG
37gynecomastia10.0BRCA2, BRCA1
38pernicious anemia10.0TPO, TG
39toxic diffuse goiter10.0TG, TPO
40endemic goiter10.0TG, TPO
41nontoxic goiter10.0TG, TPO
42plummer's disease10.0TG, TPO
43thyrotropin deficiency, isolated10.0TPO, TG
44multiple endocrine neoplasia10.0BRCA2, TG
45myxedema10.0TG, TPO
46nodular goiter10.0TG, TPO
47pendred syndrome10.0TG, TPO
48lynch syndrome10.0BRCA2, BRCA1
49follicular thyroid carcinoma10.0TG, TPO
50turner syndrome10.0TG, TPO

Graphical network of the top 20 diseases related to Premature Menopause:



Diseases related to premature menopause

Clinical Features for Premature Menopause

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Drugs & Therapeutics for Premature Menopause

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Premature Menopause

Drug clinical trials:

Search ClinicalTrials for Premature Menopause

Search NIH Clinical Center for Premature Menopause

Search CenterWatch for Premature Menopause

Inferred drug relations via UMLS61/NDF-RT41:

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Genetic Tests for Premature Menopause

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Anatomical Context for Premature Menopause

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33MalaCards
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MalaCards organs/tissues related to Premature Menopause:

33
Ovary, Thyroid, Breast, T cells

Animal Models for Premature Menopause or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Premature Menopause:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
skeleton phenotype
MP:00053908.4BRCA1, BRCA2, POLG, FSHR
2
integument phenotype
MP:00107718.2BRCA1, BRCA2, POLG, FSHR
3
immune system phenotype
MP:00053878.0BRCA1, BRCA2, POLG, FSHR, TPO
4
nervous system phenotype
MP:00036317.6TG, FSHR, POLG, BRCA2, BRCA1
5
homeostasis/metabolism phenotype
MP:00053767.5TG, TPO, FSHR, BRCA2, BRCA1
6
endocrine/exocrine gland phenotype
MP:00053797.3TG, TPO, FSHR, POLG, BRCA2, BRCA1
7
hematopoietic system phenotype
MP:00053977.3BRCA1, BRCA2, POLG, FSHR, TPO, TG
8
growth/size phenotype
MP:00053787.2BRCA1, BRCA2, POLG, FSHR, TPO, TG

Publications for Premature Menopause

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51PubMed
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Articles related to Premature Menopause:

(show top 50)    (show all 114)
idTitleAuthorsYear
1
Premature menopause in young breast cancer: effects on quality of life and treatment interventions. (23819028)
2013
2
Premature menopause or early menopause and risk of ischemic stroke. (21993082)
2012
3
Factors associated with premature ovarian failure, early menopause and earlier onset of menopause in Japanese women. (22572589)
2012
4
Premature menopause and severity of coronary artery disease. (22279478)
2011
5
Hormone replacement therapy and women with premature menopause--a cancer survivorship issue. (21561765)
2011
6
Premature menopause: a comprehensive understanding of psychosocial aspects. (21854296)
2011
7
Menopause and sexuality: key issues in premature menopause and beyond. (20840281)
2010
8
Estrogen receptor-1 genetic polymorphisms for the risk of premature ovarian failure and early menopause. (20095908)
2010
9
Premature ovarian failure, menopause and ovarian cancer, three nodes on the same string: Pten and other potential genes on the go. (19733443)
2009
10
Premature menopause: exploring the experience through online communication. (19298304)
2009
11
Successful pregnancy with frozen embryo transfer into a gestational carrier from eggs obtained from a woman in premature menopause. (19860356)
2009
12
HRT in premature menopause. (18796482)
2008
13
Premature menopause: Hormone replacement therapy is indeed indicated. (18497386)
2008
14
Ovulation induction and pregnancy in a woman with premature menopause following gonadotropin suppression with the gonadotropin releasing hormone antagonist, cetrorelix--a case report. (18404830)
2008
15
Premature menopause: Article's recommendation of HRT is highly questionable. (18467384)
2008
16
Treatment-related risk factors for premature menopause following Hodgkin lymphoma. (17890454)
2008
17
Effect of premature menopause on sexuality. (19804022)
2007
18
Do survivors of childhood cancer have increased incidence of premature menopause? (17259929)
2007
19
Management of premature menopause. (17448268)
2007
20
Premenopausal factors influencing premature ovarian failure and early menopause. (17531410)
2007
21
Diabetes and premature menopause: is their co-existence detrimental to the skeleton? (15757861)
2005
22
Bilateral oophorectomy and premature menopause. (16414338)
2005
23
Sexual dysfunction in women with premature menopause. (15543028)
2004
24
Premature menopause in a multi-ethnic population study of the menopause transition. (12525467)
2003
25
Bone density patterns after normal and premature menopause. (12697368)
2003
26
Premature menopause raises risks of fatal adrenal condition. Early diagnosis can lead to effective treatment for women. (12420381)
2002
27
Premature menopause: multiple disruptions between the woman's biological body experience and her lived body. (11843980)
2002
28
Should women with premature menopause be screened for FMR-1 mutations? (11256878)
2001
29
Premature menopause: a multidisciplinary approach whurr. (22049459)
2001
30
Possibilities of sterility therapy in a patient with a premature menopause due to an X-chromosomal anomaly - a case report. (11137332)
2000
31
Premature menopause after cancer treatment. (10352073)
1999
32
The risk of premature menopause induced by chemotherapy for early breast cancer. (10534297)
1999
33
The impact of premature menopause on women's experience of self. (10818847)
1999
34
Ovarian autoimmunity: greater frequency of autoantibodies in premature menopause and unexplained infertility than in the general population. (10075866)
1999
35
Duplication in the long arm of the X-chromosome associated with spastic paraparesis and premature menopause. (8267930)
1993
36
Premature menopause because of an inherited deletion in the long arm of the X-chromosome. (2001764)
1991
37
Lymphocyte abnormalities in premature menopause. (2116332)
1990
38
An association among blepharophimosis, resistant ovary syndrome, and true premature menopause. (3141218)
1988
39
Premature menopause. (3502933)
1987
40
Ovulation after treatment with ethinyl-oestradiol and medroxyprogesterone acetate in a woman approaching premature menopause. Case report. (3096369)
1986
41
Myasthenia gravis, premature menopause, and thyroid autoimmunity. (7405986)
1980
42
Vascular disease risk factors in women with premature menopause. (7390402)
1980
43
Identification of differing etiologies of clinically diagnosed premature menopause. (463997)
1979
44
Premature menopause: a reversible entity? (224354)
1979
45
A 5/X chromosomal translocation in a patient with premature menopause. (874310)
1977
46
Mumps oophoritis: a cause of premature menopause. (1171028)
1975
47
Hereditary polyneuropathy, oligophrenia, premature menopause and acromicria. A new syndrome. (5117105)
1971
48
Premature menopause. A clinical, histologic, and cytogenetic study. (5410380)
1970
49
Early premature menopause. A report of 6 cases with cytogenetic findings. (5951624)
1966
50
Granulosa-cell tumor of the ovary; report of five cases with premature menopause (amenorrhea) and the recurrence of menstruation. (21023761)
1946

Genetic Variations for Premature Menopause

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Expression for genes affiliated with Premature Menopause

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Premature Menopause

Search GEO for disease gene expression data for Premature Menopause.

Pathways for genes affiliated with Premature Menopause

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30KEGG, 54Reactome, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database
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Pathways related to Premature Menopause according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Fanconi anemia pathway30
9.3BRCA2, BRCA1
2
Homologous Recombination Repair54
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9.3BRCA2, BRCA1
3
BRCA1 Pathway52
9.3BRCA2, BRCA1
4
DNA damage Role of Brca1 and Brca2 in DNA repair
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9.3BRCA2, BRCA1
5
Fanconi Anemia pathway54
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9.3BRCA1, BRCA2
6
Allograft rejection30
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9.1TG, TPO
7
Insulin secretion30
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9.1TG, TPO
8
Chks in Checkpoint Regulation52
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8.9POLG, BRCA2, BRCA1

Compounds for genes affiliated with Premature Menopause

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45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 2BitterDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Premature Menopause according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1h2o24510.4TPO
2aphidicolin459.7POLG, BRCA1
38-oxoguanine459.7BRCA1, BRCA2
4lycopene45 2410.7BRCA1, BRCA2
5nevirapine45 50 1111.6TG, POLG
6iodotyrosine45 2410.6TG, TPO
7diiodotyrosine459.6TPO, TG
8indole-3-carbinol459.6BRCA2, BRCA1
9perchlorate459.5TPO, TG
10sodium iodide459.5TPO, TG
11propylthiouracil45 2 1111.5TG, TPO
12gliadin459.5TG, TPO
13p005459.5TPO, BRCA1
14chromium459.5TPO, TG
15iodine45 2410.5TG, TPO
16amiodarone45 50 29 1112.4TG, TPO
17125i459.4TPO, TG
18iodide45 2410.4TG, TPO
19methylmethanesulfonate459.4BRCA2, BRCA1
20cardiolipin45 1110.4TPO, TG
21methimazole45 2 1111.3TG, TPO
22bleomycin45 1110.3BRCA2, BRCA1
23agarose459.3TPO, FSHR, BRCA1
24daidzein459.3TPO, BRCA2, BRCA1
25polyacrylamide459.3BRCA1, BRCA2, FSHR
264-hydroxytamoxifen459.2BRCA2, BRCA1
27estradiol45 11 2411.0BRCA1, BRCA2, FSHR
28ribonucleic acid459.0TG, TPO, FSHR
29guanine45 11 2411.0BRCA1, FSHR, TG
30selenium45 249.9TG, TPO, BRCA1
31adpribose458.9BRCA1, BRCA2, TG
32acetylcholine45 50 29 11 2412.9TG, TPO, FSHR
33triiodothyronine458.8TG, TPO
34steroid458.8TPO, FSHR, BRCA2, BRCA1
35oligonucleotide458.7BRCA1, BRCA2, FSHR, TPO
36adenylate458.7TG, TPO, FSHR, POLG
37paraffin458.6TG, BRCA2, BRCA1
38alanine458.5TG, FSHR, POLG, BRCA1
39glutamine458.5TG, POLG, BRCA2, BRCA1
40cisplatin45 50 60 1111.5BRCA1, BRCA2, TG
41gold458.4BRCA1, BRCA2, TPO, TG
42genistein45 29 60 2 11 2413.4BRCA1, BRCA2, TPO, TG
43cycloheximide458.4BRCA1, BRCA2, TPO, TG
44estrogen458.4TG, FSHR, BRCA2, BRCA1
45cysteine458.4TG, TPO, FSHR, BRCA1
46retinoic acid45 249.3BRCA1, BRCA2, TPO, TG
47thymidine45 249.1TG, FSHR, POLG, BRCA2, BRCA1
48testosterone45 60 11 2411.0BRCA1, BRCA2, FSHR, TPO, TG

GO Terms for genes affiliated with Premature Menopause

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16Gene Ontology
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Biological processes related to Premature Menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1female gonad developmentGO:0085859.4BRCA2, FSHR
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.3BRCA2, BRCA1
3double-strand break repairGO:0063029.3BRCA2, BRCA1
4hormone biosynthetic processGO:0424469.2TG, TPO
5thyroid hormone generationGO:0065909.2TG, TPO
6double-strand break repair via homologous recombinationGO:0007249.0BRCA2, BRCA1

Molecular functions related to Premature Menopause according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.5POLG, BRCA2

Products for genes affiliated with Premature Menopause

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Premature Menopause

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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