MCID: PRM019
MIFTS: 65

Premature Ovarian Failure malady

Summaries for Premature Ovarian Failure

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Premature ovarian failure (pof) is when a woman's ovaries stop working before she is 40. pof is different from premature menopause. with premature menopause, your periods stop before age 40. you can no longer get pregnant. the cause can be natural or it can be a disease, surgery, chemotherapy, or radiation. with pof, some women still have occasional periods. they may even get pregnant. in most cases of pof, the cause is unknown. missed periods are usually the first sign of pof. later symptoms may be similar to those of natural menopause: hot flashes night sweats irritability poor concentration decreased sex drive pain during sex vaginal dryness doctors diagnose pof by doing a physical exam and lab and imaging tests. most women with pof cannot get pregnant naturally. fertility treatments help a few women; others use donor eggs to have children. there is no treatment that will restore normal ovarian function. however, many health care providers suggest taking hormones until age 50. nih: national institute of child health and human development

MalaCards: Premature Ovarian Failure, also known as ovarian failure, premature, is related to ovarian disease and polycystic ovary syndrome. An important gene associated with Premature Ovarian Failure is DIAPH2 (diaphanous-related formin 2), and among its related pathways is Ovarian Infertility Genes. The drugs estradiol and estrogens, conjugated (usp) have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and bone, and related mouse phenotypes are normal and endocrine/exocrine gland.

Wikipedia:63 Premature Ovarian Failure (POF), also known as premature ovarian insufficiency (POI), primary ovarian... more...

Description from OMIM:46 612964, 612310, 611548, 311360, 608996 300510, 300511 more

Aliases & Classifications for Premature Ovarian Failure

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Sources:
8Disease Ontology, 9diseasecard, 22GTR, 46OMIM, 10DISEASES, 33MedlinePlus, 30LifeMap Discovery™, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

premature ovarian failure 8 9 22 46 10 33 30
ovarian failure, premature 60
ovarian failure premature 44


External Ids:

Disease Ontology8 DOID:5426
NCIt39 C62595
SNOMED-CT56 237788002
MeSH34 D016649

Related Diseases for Premature Ovarian Failure

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Premature Ovarian Failure family:

Premature Ovarian Failure, Familial Premature Ovarian Failure 7
Premature Ovarian Failure 5 Premature Ovarian Failure 6
Premature Ovarian Failure 2a Premature Ovarian Failure 2b
Premature Ovarian Failure 3 Premature Ovarian Failure 4

Diseases related to Premature Ovarian Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1ovarian disease31.0GDF9, FMR1, FOXL2
2polycystic ovary syndrome30.8GDF9, NR5A1, BMP15, INHA
3fragile x syndrome30.7FRAXA, FRAXE, FMR1
4turner syndrome30.6SHOX, BMP15
5infertility30.6GDF9, BMP15, INHA, FIGLA, NR5A1, FOXL2
6amenorrhea30.3BMP15
7gonadal dysgenesis30.3NR5A1
8hypogonadism30.3NR5A1
9blepharophimosis, ptosis, and epicanthus inversus syndrome30.3FOXL2, GDF9
10premature menopause10.6
11osteosclerosis with ichthyosis and premature ovarian failure10.6
12ovarian cancer10.5
13thyroiditis10.5
14premature ovarian failure, familial10.4
15premature ovarian failure 710.4
16premature ovarian failure 510.4
17premature ovarian failure 610.4
18premature ovarian failure 2b10.4
19ovarian lymphoma10.4
20addison's disease10.4
21fragile x-associated primary ovarian insufficiency10.4
22autoimmune thyroiditis10.3
23galactosemia10.3
24hodgkin's lymphoma10.3
25blepharophimosis, ptosis, and epicanthus inversus syndrome type 210.3
26premature ovarian failure 2a10.3
27premature ovarian failure 310.3
28premature ovarian failure 410.3
29systemic lupus erythematosus10.2
30blepharophimosis10.2
31down syndrome10.2
32proximal symphalangism10.2
33osteoporosis10.2
34breast cancer10.2
35lupus erythematosus10.2
36myasthenia gravis10.2
37vaginitis10.2
38triple x syndrome10.2
39blepharophimosis, ptosis, and epicanthus inversus syndrome type 110.2
40autoimmune lymphoproliferative syndrome10.1
41hajdu-cheney syndrome10.1
42hyperprolactinemia10.1
43hypoparathyroidism10.1
44empty sella syndrome10.1
45diabetes insipidus10.1
46beckwith-wiedemann syndrome10.1
47protein-losing enteropathy10.1
48clear cell adenofibroma10.1
49ulcerative colitis10.1
50hypogonadotropism10.1

Graphical network of the top 20 diseases related to Premature Ovarian Failure:



Diseases related to premature ovarian failure

Clinical Features for Premature Ovarian Failure

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Sources:
46OMIM
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Clinical features from OMIM:

612964,612310,611548,311360,608996,300510,300511

Drugs & Therapeutics for Premature Ovarian Failure

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Premature Ovarian Failure

Drug clinical trials:

Search ClinicalTrials for Premature Ovarian Failure

Search NIH Clinical Center for Premature Ovarian Failure

Search CenterWatch for Premature Ovarian Failure

Inferred drug relations via UMLS60/NDF-RT40:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Premature Ovarian Failure cell therapies at LifeMap Discovery.

Genetic Tests for Premature Ovarian Failure

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22GTR
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Genetic tests related to Premature Ovarian Failure:

id Genetic test Affiliating Genes
1 Premature Ovarian Failure22

Anatomical Context for Premature Ovarian Failure

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Premature Ovarian Failure:

32
Ovary, Testes, Bone, Thyroid, Breast, Endothelial, Bone marrow, Monocytes, T cells, Eye, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Premature Ovarian Failure:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate
3 OvaryOvigerous CordOvum Potential therapeutic candidate, affected by disease
4 OvaryPrimordial FolliclePrimary Oocyte Potential therapeutic candidate, affected by disease
5 OvaryPrimary FolliclePrimary Oocyte Potential therapeutic candidate, affected by disease
6 OvaryAntral FollicleSecondary Oocyte Potential therapeutic candidate, affected by disease
7 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Premature Ovarian Failure or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Premature Ovarian Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.5FOXO4, DIAPH2, NR5A1, POF1B, INHA, DACH2
2MP:000537910.5MSH5, FMR1, FOXL2, FOXE1, BMP15, NR5A1
3MP:000538910.3FMR1, FOXL2, BMP15, NR5A1, FIGLA, GDF9

Publications for Premature Ovarian Failure

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50PubMed
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Articles related to Premature Ovarian Failure:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Human amniotic epithelial cells can differentiate into granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure. (24406076)
2013
2
A case of premature ovarian failure in a 33-year-old woman. (23509644)
2013
3
Mutational analysis of the FST gene in Chinese women with idiopathic premature ovarian failure. (23113792)
2013
4
Screening for mutations of the FOXO4 gene in premature ovarian failure patients. (22285440)
2012
5
Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure. (22101081)
2012
6
Hormone replacement therapy regimens in chemotherapy-induced premature ovarian failure and the subsequent correction of hormone levels. (23391877)
2012
7
The first case described: monozygotic twin sisters with the fragile X premutation but with a different phenotype for premature ovarian failure. (21300345)
2011
8
New candidate gene POU5F1 associated with premature ovarian failure in Chinese patients. (21273125)
2011
9
Use of hormone replacement therapy for correction of high turnover bone disease in hypogonadal I^-Thalassemia major patients presenting with osteoporosis: comparison with idiopathic premature ovarian failure. (22074125)
2011
10
Premature ovarian failure in a woman with a balanced 15;21 translocation: a case report. (21714880)
2011
11
Toward gene therapy of premature ovarian failure: intraovarian injection of adenovirus expressing human FSH receptor restores folliculogenesis in FSHR(-/-) FORKO mice. (20086006)
2010
12
Leptin and adiponectin blood levels in women with premature ovarian failure and age- and weight-matched women with normal menstrual cycles. (19609224)
2010
13
X chromosome inactivation does not define the development of premature ovarian failure in fragile X premutation carriers. (20101683)
2010
14
Two FSHR variants, haplotypes and meta-analysis in Chinese women with premature ovarian failure and polycystic ovary syndrome. (20399696)
2010
15
Myasthenia gravis accompanied by premature ovarian failure and aggravation by estrogen. (20228602)
2010
16
Breast density in women with premature ovarian failure or postmenopausal women using hormone therapy: analytical cross-sectional study. (21120432)
2010
17
Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns. (18281036)
2009
18
An estrogen treatment may reverse a premature ovarian failure. (19230878)
2009
19
Very early premature ovarian failure in two sisters compound heterozygous for the FMR1 premutation. (19041959)
2009
20
Premature ovarian failure, menopause and ovarian cancer, three nodes on the same string: Pten and other potential genes on the go. (19733443)
2009
21
Do etiologies of premature ovarian aging (POA) mimic those of premature ovarian failure (POF)? (19617205)
2009
22
Array comparative genomic hybridization profiling analysis reveals deoxyribonucleic acid copy number variations associated with premature ovarian failure. (19837940)
2009
23
Analysis of LHX8 mutation in premature ovarian failure. (17624344)
2008
24
Recent developments in identifying genetic determinants of premature ovarian failure. (18987497)
2008
25
FOXO3a variants in patients with premature ovarian failure. (17888023)
2008
26
Restoration of menstruation in premature ovarian failure after initiation of adalimumab. (18752150)
2008
27
Non-chromosomal, non-iatrogenic premature ovarian failure in an adolescent population: a case series. (18312793)
2008
28
Genetic analysis of premature ovarian failure: role of forkhead and TGF-beta genes]. (18692424)
2008
29
Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure. (17664466)
2007
30
NOBOX homeobox mutation causes premature ovarian failure. (17701902)
2007
31
Hysterectomy with preservation of both ovaries does not result in premature ovarian failure. (17593871)
2007
32
Functional analysis of the human inhibin alpha subunit variant A257T and its potential role in premature ovarian failure. (17933751)
2007
33
Premenopausal factors influencing premature ovarian failure and early menopause. (17531410)
2007
34
Alpha-enolase: a novel autoantigen in patients with premature ovarian failure. (17121525)
2006
35
X-linked premature ovarian failure: a complex disease. (16650756)
2006
36
Assessing the emotional needs of women with spontaneous premature ovarian failure. (15950644)
2005
37
Galactose-1-phosphate uridyl transferase gene mutations in women with premature ovarian failure. (16009197)
2005
38
Premature ovarian failure and forkhead transcription factor FOXL2: blepharophimosis-ptosis-epicanthus inversus syndrome and ovarian dysfunction. (16208278)
2005
39
Myasthenia gravis and premature ovarian failure. (15266640)
2004
40
G769A variation of inhibin alpha-gene in korean women with premature ovarian failure. (15227735)
2004
41
Premature ovarian failure in women with juvenile idiopathic arthritis (JIA). (12846055)
2003
42
Reduced ovarian complement, premature ovarian failure, and Down syndrome. (11241483)
2001
43
Physical mapping of nine Xq translocation breakpoints and identification of XPNPEP2 as a premature ovarian failure candidate gene. (10894934)
2000
44
No evidence for parent of origin influencing premature ovarian failure in fragile X premutation carriers. (10848495)
2000
45
Imprinting effect in premature ovarian failure confined to paternally inherited fragile X premutations. (10677300)
2000
46
Twinning and premature ovarian failure in premutation fragile X carriers. (10208171)
1999
47
A mouse gene encoding an oocyte antigen associated with autoimmune premature ovarian failure. (10433232)
1999
48
A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility. (9497258)
1998
49
Eleven X chromosome breakpoints associated with premature ovarian failure (POF) map to a 15-Mb YAC contig spanning Xq21. (9070928)
1997
50
The use of human recombinant gonadotropin receptors to search for immunoglobulin G-mediated premature ovarian failure. (7883837)
1995

Genetic Variations for Premature Ovarian Failure

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Expression for genes affiliated with Premature Ovarian Failure

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Premature Ovarian Failure

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Pathways for genes affiliated with Premature Ovarian Failure

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37NCBI BioSystems Database
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Pathways related to Premature Ovarian Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5MSH5, INHA, GDF9, NR5A1

Compounds for genes affiliated with Premature Ovarian Failure

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GO Terms for genes affiliated with Premature Ovarian Failure

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16Gene Ontology
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Biological processes related to Premature Ovarian Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ovarian follicle developmentGO:00154110.6NOBOX, INHA, BMP15, FOXL2
2female gamete generationGO:00729210.6GDF9, DIAPH2, BMP15
3cell differentiationGO:03015410.5FOXL2, DIAPH2, NR5A1, INHA, NOBOX
4tissue developmentGO:00988810.5NR5A1, FOXO4
5pattern specification processGO:00738910.4FOXO4, FOXE1, FOXL2
6oogenesisGO:04847710.2NOBOX, DIAPH2

Molecular functions related to Premature Ovarian Failure according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356510.7FOXL2, FOXE1, FOXO4, NR5A1, FIGLA, NOBOX
2DNA binding, bendingGO:00830110.6FOXO4, FOXE1, FOXL2
3transcription factor bindingGO:00813410.6FOXL2, FOXE1, FOXO4, FIGLA
4RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.5FOXL2, NR5A1, FOXE1
5cytokine activityGO:00512510.5INHA, GDF9, BMP15
6double-stranded DNA bindingGO:00369010.4FOXE1, FOXL2, NR5A1
7growth factor activityGO:00808310.2INHA, GDF9, BMP15

Products for genes affiliated with Premature Ovarian Failure

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Sources for Premature Ovarian Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet