Premature Ovarian Failure malady

MedlinePlus: Premature ovarian failure (pof) is when a woman's ovaries stop working before she is 40. pof used to be called premature menopause. however, pof is not the same as menopause. some women with pof still have occasional periods. premature menopause is when periods stop before age of 40. this can be natural or caused by surgery, chemotherapy or radiation. missed periods are usually the first sign of pof. later symptoms may be similar to those of natural menopause. most women with pof cannot get pregnant naturally. fertility treatments help a few women; others use donor eggs to have children. there is no treatment that will restore normal ovarian function. however, many health care providers suggest taking hormones until age 50. nih: national institute of child health and human development²³

MalaCards: Premature Ovarian Failure, also known as premature ovarian failure (disorder), is related to fragile x syndrome and gonadal dysgenesis. An important gene associated with Premature Ovarian Failure is POF1B (premature ovarian failure, 1B), and among its related pathways are Recycling of eIF2:GDP and Meiotic Recombination. The drugs estrogens and estropipate and the compounds ly294002 and acth 1-24 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and monocytes, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Wikipedia: Premature Ovarian Failure (POF), also known as premature ovarian insufficiency, primary ovarian...⁴⁴ more...

OMIM: 300511

Aliases & Descriptions:

premature ovarian failure 6 7 17 8 33 23 premature ovarian failure (disorder) 6

ovarian failure, premature 43 ovarian failure premature 32

Disease types for premature ovarian failure family:

premature ovarian failure 7	premature ovarian failure 4
premature ovarian failure 3	premature ovarian failure 6
premature ovarian failure 5	premature ovarian failure 2b

Diseases related to premature ovarian failure by text searches and GeneDecks gene sharing:

(show top 50)    (show all 337)

id	Related Disease	Score	Top Affiliating Genes
1	fragile x syndrome	32.8	FRAXA, FRAXE, FMR1, GNRH1, AFF2
2	gonadal dysgenesis	31.2	BRD2, BMP15, FSHR, AMH, GNRH1, HSD3BP4
3	fragile x-associated primary ovarian insufficiency	30.8	FSHR, IGFBP1, GNRH1, CYP19A1, SHBG, PRL
4	premature menopause	30.8	FSHR, TPO, POLG
5	blepharophimosis, ptosis, and epicanthus inversus syndrome	30.6	FOXL2, FOXP2, OSR2
6	galactosemia	30.2	FSHB, INS, PMM2, GALT, GDF9
7	addison's disease	30.1	INS, HSD3BP4, AIRE, TPO, CYP11A1, CYP17A1
8	polycystic ovary syndrome	29.9	FSHR, AR, INS, IGFBP1, IGF2, IGF1
9	turner syndrome	29.1	BMP15, IGFBP1, IGF1, TPO, CYP21A2, SHBG
10	amenorrhea	26.1	RFPL4A, BRD2, BMP15, LGR6, FSHB, FSHR
11	hypogonadism	25.4	BRD2, LGR6, FSHB, FSHR, AR, INHA
12	blindness	24.1	FSHB, FOXO1, AR, INHA, INS, IL2RB
13	thyroiditis	21.6	NCOA6, KITLG, LGR6, ATM, FSHB, FSHR
14	sex cord-gonadal stromal tumor	13.8	FSHR, INHA, INHBA, HSD3BP4, NR5A1
15	ovarioleukodystrophy	13.8	EIF2B2, EIF2B4, EIF2B5
16	mayer-rokitansky-kuster-hauser syndrome	13.8	AMH, AMHR2, WNT4, GALT
17	rokitansky-kuster-hauser syndrome	13.8	AMH, AMHR2, SHOX, WNT4, GALT
18	leukoencephalopathy with vanishing white matter	13.8	EIF2B2, EIF2B4, EIF2B5
19	x-linked disease	13.7	ZFX, FRAXE, AFF2
20	3-beta-hydroxysteroid dehydrogenase deficiency	13.7	HSD3BP4, CYP17A1, CYP21A2
21	cerebellar hypoplasia	13.6	LGR6, FSHR, FOXE1, CYP11A1, NR5A1
22	46, xy disorders of sexual development	13.6	FOXL2, AR, CYP17A1, NR5A1
23	autoimmune polyendocrine syndrome type 1	13.6	AIRE, CYP11A1, CYP17A1, CYP21A2
24	46, xy disorders of sex development	13.6	AR, NR5A1, WNT4
25	disorders of sex development	13.6	FOXL2, AR, CYP21A2, NR5A1, WNT4
26	pervasive developmental disorder	13.6	FRAXA, FRAXE, FOXP2, RPL10
27	hypothyroidism	13.6	FSHR, FOXE1, AIRE, TPO, SHBG
28	male pseudohermaphroditism due to defective lh	13.6	AR, AMH, HSD3BP4, CYP17A1, NR5A1
29	precocious puberty, male	13.6	FSHR, CYP19A1, CYP21A2
30	conn's syndrome	13.6	CYP11A1, CYP17A1, CYP21A2, AGTR2
31	aorta atresia	13.5	INHA, GNRH1, CYP19A1, GDF9
32	micropenis	13.5	AR, GNRH1, CYP17A1, NR5A1
33	sertoli cell tumor	13.4	AR, INHA, CYP19A1, NR5A1
34	21-hydroxylase deficiency	13.4	BRD2, GNRH1, CYP11A1, CYP17A1, CYP21A2
35	complete androgen insensitivity syndrome	13.3	AR, CYP19A1, SHBG
36	androgen insensitivity syndrome, partial	13.3	AR, CYP19A1, SHBG
37	penis paget's disease	13.3	BRD2, SHBG, PRL
38	adrenocortical insufficiency	13.3	INS, CYP21A2, NR5A1
39	androgenetic alopecia	13.2	AR, CYP19A1, CYP21A2, SHBG
40	sexual disorder	13.2	BRD2, SHBG, PRL
41	dosage-sensitive sex reversal	13.2	ESR1, CYP11A1, NR5A1, WNT4
42	testicular disease	13.2	BRD2, GNRH1, SHBG, PRL
43	testicular germ cell cancer	13.2	KITLG, AR, ESR2, POLG
44	alopecia universalis	13.2	INS, AIRE, CYP21A2
45	autoimmune polyendocrine syndrome	13.2	INS, AIRE, TPO, CYP21A2
46	wagr syndrome	13.1	FSHB, IGF2, H19
47	hypogonadism, hypergonadotropic	13.1	FSHR, CYP19A1, SHBG, PRL
48	gonadotropin deficiency	13.1	FSHR, GNRH1, CYP19A1, PRL
49	hyperproinsulinemia	13.1	INS, IGFBP1, SHBG
50	mental retardation syndrome	13.1	ATM, FRAXA, FRAXE, FMR1, AR, SHBG

Clinical features from OMIM: 300511

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 estradiol, estradiol 17-beta, estradiol acetate, estradiol cypionate, estradiol pwdr [va product], estradiol valerate, estrogens, estrogens,conjugated, estrogens,conjugated synthetic a, estrogens,conjugated synthetic b, estrogens,esterified, estrone, estrone sodium sulfate, estropipate, ethinyl estradiol, polyestradiol, polyestradiol phosphate

MalaCards organs/tissues related to premature ovarian failure:

²²

MGI Mouse Phenotypes related to premature ovarian failure:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.2	IGF2, AMHR2, TGFBR3, POLG, WNT4, INHA
2	endocrine/exocrine gland phenotype	MP:0005379	8.9	GNRH1, AIRE, DMC1, DAZL, SPO11, NR5A1
3	immune system phenotype	MP:0005387	8.3	AMHR2, GNRH1, AIRE, CYP11A1, CYP19A1, SPO11
4	embryogenesis phenotype	MP:0005380	8.3	NOG, PRLR, PRL, POLG, PMM2, WNT4
5	limbs/digits/tail phenotype	MP:0005371	8.2	H19, WNT4, PRLR, TGFBR3, NOG, ESR2
6	liver/biliary system phenotype	MP:0005370	8.2	H19, PRL, CYP19A1, AIRE, ESR2, IGFBP1
7	craniofacial phenotype	MP:0005382	8.2	INHBB, IGF2, PTEN, NOG, OSR2, PMM2
8	reproductive system phenotype	MP:0005389	7.6	NCOA6, INHBA, INHBB, MEIG1, IL2RB, GPR3
9	hearing/vestibular/ear phenotype	MP:0005377	7.4	OSR2, NOG, NTRK3, CYP19A1, ESR2, IGF1
10	vision/eye phenotype	MP:0005391	7.3	AIRE, TRPC6, PTEN, NTRK3, NOG, OSR2
11	no phenotypic analysis	MP:0003012	7.2	AMHR2, ESR1, ESR2, AIRE, POLG, H19
12	normal phenotype	MP:0002873	6.8	NR5A1, NTRK3, CYP19A1, CYP11A1, DACH2, NOG
13	renal/urinary system phenotype	MP:0005367	6.7	ESR1, ESR2, PTEN, NOG, AGTR2, WNT4
14	digestive/alimentary phenotype	MP:0005381	6.3	IGF2, GNRH1, ESR1, ESR2, AIRE, PTEN
15	mortality/aging	MP:0010768	6.2	NTRK3, CYP17A1, CYP11A1, PTEN, TPO, AIRE
16	tumorigenesis	MP:0002006	6.2	GNRH1, ESR1, ESR2, AIRE, PTEN, AGTR2
17	skeleton phenotype	MP:0005390	6.1	PTEN, CYP19A1, NOG, AGTR2, TGFBR3, OSR2
18	adipose tissue phenotype	MP:0005375	6.0	ESR2, PTEN, CYP19A1, EIF2B5, AGTR2, PRLR
19	muscle phenotype	MP:0005369	5.7	TRPC6, PTEN, CYP11A1, CYP19A1, NOG, AGTR2
20	behavior/neurological phenotype	MP:0005386	5.4	CYP17A1, CYP11A1, PTEN, TRPC6, AIRE, ESR2
21	integument phenotype	MP:0010771	4.5	PTEN, TRPC6, ESR2, ESR1, GNRH1, AMHR2
22	cardiovascular system phenotype	MP:0005385	4.3	NTRK3, CYP19A1, DIAPH2, PTEN, TRPC6, NR5A1
23	homeostasis/metabolism phenotype	MP:0005376	3.7	CYP11A1, DMC1, PTEN, TPO, AIRE, ESR2
24	growth/size phenotype	MP:0005378	3.6	CYP11A1, PTEN, TPO, AIRE, ESR2, ESR1
25	cellular phenotype	MP:0005384	3.3	LHX8, SALL4, MSH5, ATM, FSHR, CDKN1B
26	nervous system phenotype	MP:0003631	3.0	NOG, NR5A1, NTRK3, CYP19A1, DIAPH2, PTEN

Articles related to premature ovarian failure:

(show top 50)    (show all 144)

id	Title	Authors	Year	Affiliating Genes
1	The POF1B candidate gene for premature ovarian failur e regulates epithelial polarity. (21940798)	Padovano V.... Pietrini G.	2011	POF1B
2	Variable expression of the Fragile X Mental Retardati on 1 (FMR1) gene in patients with premature ovarian failure syndrome is not dep endent on number of (CGG)n triplets in exon 1. (21335413)	Schuettler J.... Vogt P.H.	2011	FMR1
3	Mutation analysis of the WNT4 gene in Han Chinese wom en with premature ovarian failure. (21624127)	Chen B.... Cao Y.	2011	WNT4
4	Premature ovarian failure and FMR1 gene mutations: an update. (20398889)	Conway G.S.	2010	FMR1
5	Intermediate sized CGG repeats are not a common cause of idiopathic premature ovarian failure. (20228389)	Bennett C.E.... Murray A.	2010	FMR1
6	Mutation analysis of FOXL2 gene in Chinese patients w ith premature ovarian failure. (20222838)	Ni F.... Cao Y.	2010	FOXL2
7	Premature ovarian failure, menopause and ovarian canc er, three nodes on the same string: Pten and other potential genes on the go. (19733443)	Kuang H.... Chen Q.	2009	PTEN
8	Immunology of Addison's disease and premature ovarian failure. (19328418)	Husebye E.S.... vAYs K.	2009	CYP21A2
9	Mutational analysis of SAL-Like 4 (SALL4) in Han Chin ese women with premature ovarian failure. (19581335)	Wang B.... Cao Y.	2009	SALL4
10	Premature ovarian failure and gene polymorphisms. (19610175)	van Dooren M.F.... Oldenburg R.A.	2009	FIGLA, NOBOX
11	Very early premature ovarian failure in two sisters compound heterozygous for the FMR1 premutation. (19041959)	Van Esch H.... Matthijs G.	2009	FMR1
12	CGG repeat sizing in the FMR1 gene in Indian women wi th premature ovarian failure. (19712568)	Chatterjee S.... Meherji P.	2009	FMR1
13	Acyl-CoA synthetase long-chain family member 6 is associated with premature ovarian failure. (18555221)	Kang H.... Kwack K.	2009	ACSL6
14	Cryptic Xp duplication including the SHOX gene in a woman with 46,X, del(X)(q21.31) and premature ovarian failure. (17981816)	Tachdjian G.... Christin-Maitre S.	2008	SHOX
15	Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea. (17959613)	Gallardo T.D.... Castrillon D.H.	2008	FOXO3
16	Association between polymorphisms in the protein L-isoaspartate (D-aspartate) O-methyltransferase gene and premature ovarian failure. (18582870)	Pyun J.A.... Kwack K.	2008	PCMT1
17	Analysis of LHX8 mutation in premature ovarian failure. (17624344)	Qin Y.... Rajkovic A.	2008	LHX8
18	Transcription factor FIGLA is mutated in patients with premature ovarian failure. (18499083)	Zhao H.... Rajkovic A.	2008	FIGLA
19	Analyses of GDF9 mutation in 100 Chinese women with premature ovarian failure. (17482612)	Zhao H.... Rajkovic A.	2007	GDF9
20	Candidate genes for premature ovarian failure. (17305537)	Suzumori N.... Rajkovic A.	2007	LHX8, FIGLA
21	Oocyte-specific G-protein-coupled receptor 3 (GPR3): no perturbations found in 82 women with premature ovarian failure (first report). (17953967)	Kovanci E.... Carson S.A.	2007	GPR3
22	Functional analysis of the human inhibin alpha subunit variant A257T and its potential role in premature ovarian failure. (17933751)	Chand A.L.... Robertson D.M.	2007	INHA
23	Follicle-stimulating hormone receptor gene mutations are not evident in Greek women with premature ovarian failure and poor responders. (16195671)	Loutradis D.... Michalas S.	2006	FSHR
24	Dominant inheritance of premature ovarian failure associated with mutant mitochondrial DNA polymerase gamma. (16595552)	Pagnamenta A.T.... Rahman S.	2006	POLG
25	Disruption of POF1B binding to nonmuscle actin filaments is associated with premature ovarian failure. (16773570)	Lacombe A.... Vilain E.	2006	POF1B
26	Prevalence of thyroid autoimmunity in sporadic idiopathic hypoparathyroidism in comparison to type 1 diabetes and premature ovarian failure. (16895958)	Goswami R.... Singh S.	2006	TPO
27	Premature ovarian failure (17194965)	Christin-Maitre S.... Bouchard P.	2006	FOXL2, BMP15
28	An investigation into FOXE1 polyalanine tract length in premature ovarian failure. (16481406)	Watkins W.J.... Shelling A.N.	2006	FOXE1
29	Premature ovarian failure (POF) syndrome: towards the molecular clinical analysis of its genetic complexity. (16719785)	Fassnacht W.... Vogt P.H.	2006	DAZL
30	Premature ovarian failure and forkhead transcription factor FOXL2: blepharophimosis-ptosis-epicanthus inversus syndrome and ovarian dysfunction. (16208278)	De Baere E.... Fellous M.	2005	FOXL2
31	Relationship of estradiol and inhibin to the follicle-stimulating hormone variability in hypergonadotropic hypogonadism or premature ovarian failure. (15562017)	Welt C.K.... Taylor A.E.	2005	INHA, INHBB
32	INHA promoter polymorphisms are associated with premature ovarian failure. (16390856)	Harris S.E.... Shelling A.N.	2005	INHA
33	Circulating auto-antibodies against the zona pellucida and thyroid microsomal antigen in women with premature ovarian failure. (15949562)	Kelkar R.L.... Nandedkar T.D.	2005	TPO
34	Mutations in the coding region of the FOXL2 gene are not a major cause of idiopathic premature ovarian failure. (15181179)	Bodega B.... Marozzi A.	2004	FOXL2
35	Screening for known mutations in EIF2B genes in a large panel of patients with premature ovarian failure. (15507143)	Fogli A.... Boespflug-Tanguy O.	2004	EIF2B2, EIF2B4, EIF2B5
36	Screening of FSH receptor gene in Argentine women with premature ovarian failure (POF). (15249125)	Sundblad V.... Charreau E.H.	2004	FSHR
37	Identification of novel mutations in FOXL2 associated with premature ovarian failure. (12149404)	Harris S.E.... Shelling A.N.	2002	FOXL2
38	Follicle-stimulating hormone receptor gene mutations are rare in Japanese women with premature ovarian failure and polycystic ovary syndrome. (11163840)	Takakura K.... Noda Y.	2001	FSHR
39	Premature ovarian failure and the FMR1 gene. (11299521)	Murray A.	2000	FMR1
40	3beta-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian failure. (10852471)	Reimand K.... Krohn K.J.	2000	CYP17A1, CYP11A1
41	Inhibin: a candidate gene for premature ovarian failure. (11098038)	Shelling A.N.... Winship I.M.	2000	INHA
42	X chromosome genes and premature ovarian failure. (11299520)	Bione S.... Toniolo D.	2000	POF1B
43	Microdeletions in FMR2 may be a significant cause of premature ovarian failure. (10528856)	Murray A.... Morton N.	1999	AFF2, FRAXE
44	A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility. (9497258)	Bione S.... Toniolo D.	1998	FMR1, DIAPH2
45	Studies of FRAXA and FRAXE in women with premature ovarian failure. (9719368)	Murray A.... Jacobs P.	1998	FMR1
46	Genes and premature ovarian failure. (9922102)	Christin-Maitre S.... Bouchard P.	1998	ATM, AIRE
47	Prevalence, specificity and significance of ovarian antibodies during spontaneous premature ovarian failure. (9455825)	FAcnichel P.... Harter M.	1997	TPO
48	Autoantibodies to steroidogenic enzymes in autoimmune polyglandular syndrome, Addison's disease, and premature ovarian failure. (8626850)	Chen S.... Furmaniak J.	1996	CYP11A1, CYP21A2
49	The use of human recombinant gonadotropin receptors to search for immunoglobulin G-mediated premature ovarian failure. (7883837)	Anasti J.N.... Nelson L.M.	1995	LGR6
50	Dysfunction of monocytes and dendritic cells in patie nts with premature ovarian failure. (8129847)	Hoek A.... Drexhage H.A.	1993	GNRH1

Genes related to premature ovarian failure according to GeneCards:

(show top 50)    (show all 96)

id	Symbol	Description	Score	GeneCards Section Context
1	POF1B	premature ovarian failure, 1B	11.1	Summaries, Publications, Transcripts, Orthologs (show all 5 sections) Aliases & Descriptions
2	FMR1	fragile X mental retardation 1	11.1	Summaries, Aliases & Descriptions, Publications
3	NOBOX	NOBOX oogenesis homeobox	11.1	Publications, Summaries
4	FOXL2	forkhead box L2	11.1	Publications, Summaries
5	FIGLA	folliculogenesis specific basic helix-loop-helix	11.1	Publications, Summaries
6	MSH5	mutS homolog 5 (E. coli)	11.1	Publications, Summaries
7	PABPC5	poly(A) binding protein, cytoplasmic 5	11.1	Disorders, Summaries
8	PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase	11.1	Summaries, Publications
9	DACH2	dachshund homolog 2 (Drosophila)	11.1	Publications, Summaries
10	DIAPH2	diaphanous homolog 2 (Drosophila)	11.1	Summaries, Publications
11	BMP15	bone morphogenetic protein 15	11.0	Publications
12	NR5A1	nuclear receptor subfamily 5, group A, member 1	11.0
13	FRAXE	fragile site, folic acid type, rare, fra(X)(q28) E	11.0	Publications
14	FRAXA	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	11.0	Publications
15	GDF9	growth differentiation factor 9	11.0	Publications
16	NANOS3	nanos homolog 3 (Drosophila)	11.0	Publications
17	GPR3	G protein-coupled receptor 3	11.0	Publications
18	RFPL4A	ret finger protein-like 4A	11.0
19	INHA	inhibin, alpha	11.0	Publications
20	GTSF1	gametocyte specific factor 1	11.0	Disorders
21	LHX8	LIM homeobox 8	11.0	Publications
22	MEIG1	meiosis expressed gene 1 homolog (mouse)	11.0	Disorders
23	OSR2	odd-skipped related 2 (Drosophila)	11.0	Publications
24	SPO11	SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)	11.0	Publications
25	TRIM61	tripartite motif containing 61	11.0	Disorders
26	PGRMC1	progesterone receptor membrane component 1	11.0	Publications
27	EIF2B2	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	11.0	Publications
28	AMHR2	anti-Mullerian hormone receptor, type II	11.0	Publications
29	SHOX	short stature homeobox	11.0	Publications
30	INHBB	inhibin, beta B	11.0	Publications
31	FOXE1	forkhead box E1 (thyroid transcription factor 2)	11.0	Publications
32	FSHR	follicle stimulating hormone receptor	11.0	Publications
33	GALT	galactose-1-phosphate uridylyltransferase	11.0	Publications
34	H1FOO	H1 histone family, member O, oocyte-specific	11.0	Disorders
35	DUPD1	dual specificity phosphatase and pro isomerase domain containing 1	11.0
36	AMH	anti-Mullerian hormone	11.0	Publications
37	AIRE	autoimmune regulator	11.0	Publications
38	XPNPEP2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	11.0	Publications
39	HSD3BP4	hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 4	11.0	Publications
40	SALL4	sal-like 4 (Drosophila)	11.0	Publications
41	NXF5	nuclear RNA export factor 5	11.0
42	EIF2B5	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	11.0	Publications
43	DAZL	deleted in azoospermia-like	11.0	Publications
44	NOG	noggin	11.0	Publications
45	SYCE1	synaptonemal complex central element protein 1	11.0
46	FSHB	follicle stimulating hormone, beta polypeptide	11.0	Publications
47	RPL10	ribosomal protein L10	11.0	Publications
48	BRSK1	BR serine/threonine kinase 1	11.0
49	INHBA	inhibin, beta A	11.0	Publications
50	WNT4	wingless-type MMTV integration site family, member 4	11.0	Publications

Pathways related to premature ovarian failure according to GeneDecks:

(show all 46)

id	Pathway	Score	Top Affiliating Genes
1	Recycling of eIF2:GDP38	10.7	EIF2B5, EIF2B4, EIF2B2
2	Meiotic Recombination38	10.6	SPO11, DMC1, MSH5, MSH4
3	TGF-beta signaling pathway20	10.2	INHBA, INHBB, AMH, AMHR2, NOG
4	Development_Role of Activin A in cell differentiation and proliferation41	10.2	FSHR, CDKN1B, INHBA, CYP11A1, NR5A1, FSHB
5	Development Role of Activin A in cell differentiation and proliferation10	10.2	NR5A1, FSHB, FSHR, CDKN1B, INHBA, CYP11A1
6	Actin-Based Motility by Rho Family GTPases36	10.0	IGF1, GDF9
7	Breast Cancer Regulation by Stathmin136	10.0	GDF9, TGFBR3, NTRK3
8	Akt Signaling36	9.9	GDF9, CXCL12, NTRK3, IL2RB, FOXO1, BMP15
9	JNK Pathway36	9.7	GDF9, CXCL12, NTRK3, IL2RB, BMP15, KITLG
10	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics34	9.6	CYP19A1, ESR2, ESR1
11	IGF1R Signaling36	9.2	EIF2B5, EIF2B4, EIF2B2, PTEN, IGF1, IGF2
12	TGF-beta Signaling Pathways37	9.2	FOXO1, FOXO3, AR, ESR1, ESR2, TGFBR3
13	Cytokine-cytokine receptor interaction20	9.1	CXCL12, PRL, PRLR, TPO, AMHR2, AMH
14	Development IGF-RI signaling10	9.1	PTEN, IGF1, IGF2, IGFBP1, FOXO3
15	Development_IGF-1 receptor signaling41	9.0	PTEN, IGF1, IGF2, IGFBP1, FOXO3
16	Molecular Mechanisms of Cancer36	8.8	GDF9, CXCL12, PTEN, GNRH1, IGF2, CDKN1B
17	Rac1 Pathway36	8.8	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
18	PPAR Pathway36	8.8	GDF9, CXCL12, TGFBR3, NTRK3, IGF1, IGF2
19	Telomerase Components in Cell Signaling36	8.7	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
20	TGF-Beta Pathway36	8.7	GDF9, CXCL12, GNRH1, IGF1, IGF2, IL2RB
21	Nanog in Mammalian ESC Pluripotency36	8.7	GDF9, WNT4, CXCL12, NTRK3, GNRH1, IGF1
22	Apoptotic Pathways in Synovial Fibroblasts36	8.6	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
23	Nuclear Receptor Activation by Vitamin-A36	8.6	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
24	GSK3 Signaling36	8.5	GDF9, WNT4, CXCL12, EIF2B5, EIF2B4, EIF2B2
25	ERK5 Signaling36	8.5	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
26	Activation of PKC through GPCR36	8.5	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
27	DHA Signaling36	8.5	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
28	PAK Pathway36	8.5	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
29	MAPK Family Pathway36	8.5	GDF9, CXCL12, TGFBR3, GNRH1, IGF1, IGF2
30	Renin-Angiotensin Pathway36	8.5	GDF9, CXCL12, TGFBR3, AGTR2, NTRK3, GNRH1
31	Prostate cancer20	8.5	PTEN, IGF1, INS, AR, FOXO1, CDKN1B
32	Mitochondrial Apoptosis36	8.4	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
33	Cellular Apoptosis Pathway36	8.4	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
34	CREB Pathway36	8.3	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
35	PTEN Pathway36	8.3	GDF9, CXCL12, TGFBR3, NTRK3, PTEN, GNRH1
36	Antioxidant Action of Vitamin-C36	8.2	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
37	Tec Kinases Signaling36	8.2	GDF9, CXCL12, NTRK3, GNRH1, IGF1, IGF2
38	p53 Mediated Apoptosis36	8.2	NTRK3, TGFBR3, CXCL12, GDF9, PTEN, GNRH1
39	Pancreatic Adenocarcinoma36	8.1	GDF9, CXCL12, NTRK3, GNRH1, IGF1, IGF2
40	mTOR Pathway36	8.1	GDF9, CXCL12, GNRH1, IGF1, IGF2, INS
41	p70S6K Signaling36	8.1	GDF9, CXCL12, TGFBR3, NTRK3, GNRH1, IGF1
42	eIF2 Pathway36	8.0	KITLG, GDF9, CXCL12, TGFBR3, EIF2B5, EIF2B4
43	Epithelial Adherens Junctions36	7.9	GDF9, CXCL12, TGFBR3, PTEN, GNRH1, IGF1
44	JAK-STAT Pathway36	7.8	AGTR2, PRLR, PRL, CXCL12, GDF9, NTRK3
45	eNOS Signaling36	7.8	GDF9, CXCL12, NTRK3, ESR2, ESR1, GNRH1
46	Estrogen Pathway36	7.7	GDF9, CXCL12, NTRK3, KITLG, IGF2, IGF1

Compounds related to premature ovarian failure according to GeneDecks:

(show top 50)    (show all 141)

id	Compound	Score	Top Affiliating Genes
1	ly29400232	9.8	CDKN1B, FOXP2
2	acth 1-2432	9.3	CYP21A2, PRL, IGF2, CYP11A1, CYP17A1
3	3beta-hydroxysteroid32	9.2	AR, INHA, CYP17A1, CYP19A1, CYP21A2, NR5A1
4	aminoglutethimide32 9 9	11.1	AR, IGF2, ESR1, CYP11A1, CYP19A1, CYP21A2
5	17-hydroxyprogesterone32 18	10.1	CYP11A1, CYP19A1, CYP21A2, PRL, SHBG, CYP17A1
6	17beta-hydroxysteroid32	8.9	ESR2, HSD3BP4, AR, CYP17A1, NR5A1, CYP21A2
7	exemestane32 34 9 9	11.9	ESR1, IGF2, AR, CYP19A1, SHBG, ESR2
8	5alpha-androstane-3alpha,17beta-diol32	8.8	ESR2, ESR1, HSD3BP4, IGF2, AR, CYP19A1
9	steroidal32	8.8	CYP17A1, GNRH1, HSD3BP4, ESR2, CYP19A1, AR
10	rapamycin32 42	9.8	KITLG, FMR1, FOXO3, FOXO1, FOXP2, IGF2
11	buserelin32 9 9	10.6	PRL, CYP19A1, GNRH1, IGFBP1, IGF1, FSHB
12	diethylstilbestrol32 9 9	10.6	SHBG, NR5A1, CYP17A1, PTEN, ESR2, ESR1
13	estradiol benzoate32	8.5	PRL, CYP19A1, ESR2, ESR1, GNRH1
14	toremifene32 9 9	10.4	CYP19A1, PRL, GNRH1, SHBG, ESR2, ESR1
15	progestins32	8.4	IGFBP1, ESR1, GNRH1, CYP19A1, SHBG, AR
16	adenylate32	8.3	FSHB, GALT, AR, FSHR, CXCL12, LGR6
17	5-aza-2deoxycytidine32	8.3	H19, CXCL12, NR5A1, PTEN, ESR2, ESR1
18	nandrolone32 18	9.3	ESR1, IGF1, AR, CYP19A1, SHBG, ESR2
19	metformin32 34 9 9	11.2	CYP11A1, CYP19A1, SHBG, CYP17A1, GNRH1, IGF1
20	levonorgestrel32 9 9	10.2	SHBG, AR, IGFBP1, CYP19A1, ESR2, ESR1
21	letrozole32 42 9 9	11.2	ESR1, AR, CYP19A1, IGF1, ESR2, SHBG
22	mifepristone32 42 9 9	11.1	AMH, PRL, SHBG, CYP19A1, ESR2, ESR1
23	gnrh32	8.0	KITLG, LGR6, FSHB, FSHR, AR, INHA
24	estrone sulfate32 18	8.8	SHBG, PRL, CYP19A1, CYP17A1, ESR1, IGF1
25	leuprolide acetate32	7.7	PRL, SHBG, CYP21A2, CYP19A1, ESR2, ESR1
26	hydrocortisone32 9 9	9.5	CYP19A1, IGF2, CYP21A2, TPO, KITLG, INS
27	thyroxine32 18	8.5	INS, IGFBP1, SHBG, CYP21A2, TPO, GNRH1
28	acth32	7.3	IGF2, IGFBP1, IL2RB, INS, INHA, FSHB
29	dehydroepiandrosterone sulfate32	7.2	AR, INS, IGFBP1, IGF2, IGF1, GNRH1
30	alanine32	7.2	INHA, INS, IL2RB, PRLR, IGFBP1, POLG
31	phosphatidylinositol32	7.1	FOXO1, FOXO3, FOXP2, IL2RB, IGFBP1, IGF2
32	dhea32	7.1	CYP21A2, NR5A1, SHBG, PRL, AR, INS
33	clomiphene citrate32	7.0	FSHB, INS, GNRH1, ESR1, PRL, SHBG
34	estrone32 9 18 9	10.0	HSD3BP4, IGF1, NR5A1, SHBG, PRL, CYP19A1
35	androstenedione32 18	7.8	PRL, SHBG, CYP21A2, CYP19A1, CYP17A1, CYP11A1
36	ribonucleic acid32	6.8	CYP21A2, NR5A1, NOG, PRLR, PRL, CXCL12
37	progestin32	6.7	CYP19A1, CYP17A1, CYP11A1, ESR2, ESR1, HSD3BP4
38	testosterone32 9 18 9	9.7	KITLG, HSD3BP4, ESR2, TPO, PTEN, CYP11A1
39	dexamethasone32 42 34 9 9	10.7	PRL, CXCL12, CDKN1B, IL2RB, HSD3BP4, AR
40	dihydrotestosterone32 9 18 9	9.4	ESR2, IGF2, IGFBP1, PRL, SHBG, CYP21A2
41	actinomycin d32	6.4	CXCL12, NR5A1, CYP11A1, ESR2, ESR1, GNRH1
42	genistein32 9 18 9	9.0	CYP19A1, PTEN, TPO, CXCL12, CYP21A2, SHBG
43	tamoxifen32 34 9 9	8.6	PTEN, ESR2, CXCL12, CYP17A1, ESR1, GNRH1
44	retinoic acid32 42 18	7.6	NOG, H19, SHBG, ESR1, NR5A1, IGFBP1
45	cycloheximide32	5.4	KITLG, CYP19A1, CYP21A2, NTRK3, NR5A1, NOG
46	arginine32	5.3	CYP17A1, CDKN1B, FMR1, INS, IL2RB, PTEN
47	estradiol32 9 18 9	8.1	IGF2, IGFBP1, INHA, AR, FOXO1, CDKN1B
48	steroid32	5.0	NCOA6, KITLG, LGR6, FSHB, FSHR, AR
49	progesterone32 42 9 18 9	8.9	HSD3BP4, GNRH1, AMH, IGF1, IGF2, IGFBP1
50	estrogen32	3.3	CDKN1B, PTEN, CYP11A1, CYP17A1, CYP19A1, CYP21A2

Cellular components related to premature ovarian failure according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	eukaryotic translation initiation factor 2B complex	GO:005851	10.2	EIF2B2, EIF2B4, EIF2B5
2	extracellular space	GO:005615	7.3	GDF9, WNT4, CXCL12, TGFBR3, NOG, GNRH1
3	extracellular region	GO:005576	6.3	GNRH1, ESR2, NOG, SHBG, AGTR2, PRLR

Biological processes related to premature ovarian failure according to GeneDecks:

(show all 27)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of follicle-stimulating hormone secretion	GO:046882	10.7	INHBB, INHBA, INHA
2	positive regulation of follicle-stimulating hormone secretion	GO:046881	10.6	INHBB, INHBA, INHA
3	cellular response to stimulus	GO:051716	10.6	EIF2B5, EIF2B4, EIF2B2
4	female gonad development	GO:008585	10.4	LHX8, FSHR, WNT4
5	sex differentiation	GO:007548	10.3	CYP17A1, AMHR2, AMH, AR
6	cell differentiation	GO:030154	10.3	OSR2, NOBOX, NR5A1, NTRK3, DIAPH2, AMH
7	phthalate metabolic process	GO:018963	10.2	CYP19A1, CYP17A1, CYP11A1
8	female gamete generation	GO:007292	10.2	GDF9, BMP15, MSH4, ATM, FSHB, FSHR
9	biphenyl metabolic process	GO:018879	10.2	CYP19A1, CYP17A1, CYP11A1
10	cellular response to follicle-stimulating hormone stimulus	GO:071372	10.2	INHBA, CYP11A1, CYP19A1
11	dibenzo-p-dioxin metabolic process	GO:018894	10.2	CYP19A1, CYP17A1, CYP11A1
12	adrenal gland development	GO:030325	10.2	WNT4, NR5A1, CYP19A1, CYP17A1
13	spermatogenesis	GO:007283	10.1	SPO11, DAZL, DMC1, MEIG1, FSHR, FSHB
14	cellular response to antibiotic	GO:071236	10.0	CYP17A1, CYP11A1, CDKN1B
15	male gonad development	GO:008584	9.9	WNT4, NR5A1, CYP19A1, INHBA, INHA, AR
16	response to ionizing radiation	GO:010212	9.7	BRSK1, ATM, CYP17A1, CYP19A1
17	ovarian follicle development	GO:001541	9.7	EIF2B5, EIF2B4, EIF2B2, NOBOX, KITLG, BMP15
18	negative regulation of cell growth	GO:030308	9.6	GDF9, AGTR2, ESR2, ENO1, INHBA, CDKN1B
19	cell-cell signaling	GO:007267	9.3	WNT4, NR5A1, ESR2, GNRH1, AMH, INS
20	negative regulation of epithelial cell proliferation	GO:050680	9.2	AR, ESR2, PTEN, TGFBR3
21	positive regulation of nitric-oxide synthase activity	GO:051000	9.1	AGTR2, ESR1, INS
22	prostate gland growth	GO:060736	9.1	PRLR, CYP19A1, PTEN, IGF1, AR
23	positive regulation of transcription, DNA-dependent	GO:045893	9.0	WNT4, OSR2, AGTR2, AIRE, IGF1, INHBA
24	phosphatidylinositol-mediated signaling	GO:048015	8.8	PTEN, IGF1, FOXO3, FOXO1, CDKN1B
25	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.5	OSR2, NOG, NOBOX, NR5A1, AIRE, ESR1
26	negative regulation of apoptotic process	GO:043066	8.3	WNT4, CXCL12, NOG, PTEN, INS, AR
27	positive regulation of cell proliferation	GO:008284	8.0	GDF9, OSR2, PTEN, IGF1, IGF2, INS

Molecular functions related to premature ovarian failure according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	chromatin binding	GO:003682	9.7	NR5A1, AIRE, AR, FOXO1, BRD2, NCOA6
2	heme binding	GO:020037	9.5	PGRMC1, CYP21A2, CYP19A1, CYP17A1, CYP11A1, TPO
3	sequence-specific DNA binding	GO:043565	9.5	OSR2, NOBOX, NR5A1, FIGLA, AR, FOXP2
4	steroid binding	GO:005496	9.5	PGRMC1, CYP21A2, ESR2, ESR1
5	growth factor activity	GO:008083	8.8	GDF9, CXCL12, AMH, IGF1, IGF2, INHBB
6	enzyme binding	GO:019899	8.5	ACSL6, NR5A1, PTEN, ESR2, ESR1, AR
7	hormone activity	GO:005179	8.1	FSHB, PRL, GNRH1, AMH, IGF1, IGF2
8	protein binding	GO:005515	4.4	DAZL, DMC1, PTEN, TRPC6, AIRE, ESR2