Aliases & Classifications for Premenstrual Tension

MalaCards integrated aliases for Premenstrual Tension:

Name: Premenstrual Tension 12 14 69
Premenstrual Syndrome 41 69 59

Classifications:



External Ids:

Disease Ontology 12 DOID:727
ICD10 32 N94.3
ICD9CM 34 625.4
MeSH 41 D011293

Summaries for Premenstrual Tension

PubMed Health : 59
About premenstrual syndrome: In the days leading up to their period, many women experience abdominal pain or a headache, are sad and irritable or feel bloated and generally uncomfortable. The medical term for this is “premenstrual syndrome” (PMS), also known as “premenstrual tension” (PMT). PMS symptoms are usually not very severe, and most women cope well with them. But in some women it is so bad that they are unable to go about their everyday lives during that time. Various treatments and measures can help to relieve PMS.

MalaCards based summary : Premenstrual Tension, also known as premenstrual syndrome, is related to anovulation and breast disease, and has symptoms including female genital pain and other symptoms, other specified symptoms associated with female genital organs and pain and other symptoms associated with female genital organs. An important gene associated with Premenstrual Tension is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Nongenotropic Androgen signaling and Glucocorticoid Pathway (HPA Axis), Pharmacodynamics. The drugs Flutamide and Guanfacine have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and cortex, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 72 Premenstrual syndrome (PMS) refers to physical and emotional symptoms that occur in the one to two weeks... more...

Related Diseases for Premenstrual Tension

Diseases related to Premenstrual Tension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 anovulation 30.1 GNRH1 PRL SHBG
2 breast disease 29.7 PGR PRL SHBG
3 acute adrenal insufficiency 10.6 POMC REN
4 hypoaldosteronism 10.5 POMC REN
5 suprasellar meningioma 10.5 POMC REN
6 perinephritis 10.5 MGAM REN
7 myofascial pain syndrome 10.5 CAMP POMC
8 central nervous system germinoma 10.5 AVP POMC
9 retroperitoneal leiomyosarcoma 10.5 PGR REN
10 tuberculous epididymitis 10.5 AVP POMC
11 endometriosis of uterus 10.4 GNRH1 PRL
12 mineral metabolism disease 10.4 MGAM POMC REN
13 central nervous system germ cell tumor 10.4 AVP POMC
14 hypogonadotropism 10.4 GNRH1 PRL
15 adenohypophysitis 10.4 POMC PRL
16 neurotic disorder 10.4 CAMP LIPN LRP5
17 pneumothorax 10.4 FLCN GNRH1 PGR
18 acth deficiency, isolated 10.4 CRH POMC
19 pituitary carcinoma 10.4 CRH POMC
20 intracystic papillary adenoma 10.4 PGR PRL
21 adrenal cortical hypofunction 10.4 CRH POMC REN
22 pituitary infarct 10.4 GNRH1 POMC PRL
23 benign essential hypertension 10.4 AVP MGAM REN
24 chiasmal syndrome 10.4 GNRH1 POMC PRL
25 pituitary apoplexy 10.4 GNRH1 POMC PRL
26 adrenal adenoma 10.3 CRH POMC REN
27 empty sella syndrome 10.3 GNRH1 POMC PRL
28 inappropriate adh syndrome 10.3 AVP POMC REN
29 adrenal carcinoma 10.3 CRH POMC REN
30 secondary hypertrophic osteoarthropathy 10.3 AVP POMC
31 freemartinism 10.3 GNRH1 OXT
32 hyperprolactinemia 10.3 GNRH1 POMC PRL
33 hypoadrenalism 10.3 CRH POMC SHBG
34 sella turcica neoplasm 10.3 PGR POMC PRL
35 tuberculum sellae meningioma 10.3 PGR POMC PRL
36 cell type benign neoplasm 10.3 POMC PRL REN
37 estrogen excess 10.3 PGR SHBG
38 prostatic adenoma 10.2 PRL SHBG
39 nelson syndrome 10.2 CRH POMC PRL
40 sheehan syndrome 10.2 CRH POMC PRL
41 acth-secreting pituitary adenoma 10.2 CRH POMC PRL
42 pain agnosia 10.2 LIPN OXT POMC
43 agnosia 10.2 LIPN OXT POMC
44 conn's syndrome 10.2 CRH POMC REN
45 pelvic varices 10.2 GNRH1 SHBG
46 postmenopausal atrophic vaginitis 10.2 OXT SHBG
47 adrenal gland hyperfunction 10.2 CRH POMC PRL
48 varicocele 10.2 GNRH1 PRL SHBG
49 bulimia nervosa 2 10.2 CRH POMC PRL
50 central nervous system organ benign neoplasm 10.2 AVP POMC PRL

Graphical network of the top 20 diseases related to Premenstrual Tension:



Diseases related to Premenstrual Tension

Symptoms & Phenotypes for Premenstrual Tension

UMLS symptoms related to Premenstrual Tension:


female genital pain and other symptoms, other specified symptoms associated with female genital organs, pain and other symptoms associated with female genital organs, mittelschmerz, unspecified symptom associated with female genital organs, pelvic pain

MGI Mouse Phenotypes related to Premenstrual Tension:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.17 PGR AVP PNN CRH POMC FLCN
2 immune system MP:0005387 9.96 PGR CAMP CRH POMC FLCN PRL
3 integument MP:0010771 9.76 OXT PGR PNN CRH POMC PRL
4 neoplasm MP:0002006 9.43 PGR POMC FLCN PRL GNRH1 HP
5 renal/urinary system MP:0005367 9.23 AVP CRH POMC FLCN GNRH1 REN

Drugs & Therapeutics for Premenstrual Tension

PubMedHealth treatment related to Premenstrual Tension: 59

There isn’t much good research on what can help reduce PMS. So it isn’t clear how effective many of the PMS treatments are.Girls and women with PMS often try out different things to reduce their symptoms. For instance, some women with mild PMS try out relaxation techniques, acupuncture, getting more exercise, drinking less alcohol and coffee, or eating less salt. Others use herbal products and dietary supplements such as chaste tree extracts (Vitex agnus castus), St. John’s wort, calcium or pyridoxine vitamin B6).More severe PMS can be treated with a number of medications. But many of these medications haven’t been approved for the treatment of PMS, and they can have side effects:Hormone medications like the birth control pill or hormone patches affect women’s hormone levels and lead to an improvement in PMS or PMDD.Antidepressants: SSRIs (selective serotonin reuptake inhibitors) can help reduce severe psychological problems caused by PMS or PMDD.Painkillers can effectively relieve severe period pain and are usually well tolerated. There is very little research on whether they also help in PMS, though.Women who have problems with PMS-related water retention can take diuretics (water pills).If PMS causes psychological problems, cognitive behavioral therapy (CBT) is an option. But it isn’t clear whether it helps in PMS.

Drugs for Premenstrual Tension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Flutamide Approved, Investigational Phase 4 13311-84-7 3397
2
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
3
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Methylphenidate Approved, Investigational Phase 4 20748-11-2, 113-45-1 4158
6
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
7
Sertraline Approved Phase 4,Phase 1,Phase 2 79617-96-2 68617
8 Androgen Antagonists Phase 4
9 Androgens Phase 4
10 Antineoplastic Agents, Hormonal Phase 4,Phase 1
11 Hormone Antagonists Phase 4,Phase 2,Phase 1
12 Hormones Phase 4,Phase 2,Phase 1
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 1
14 Adrenergic Agents Phase 4
15 Adrenergic Agonists Phase 4
16 Adrenergic alpha-2 Receptor Agonists Phase 4
17 Adrenergic alpha-Agonists Phase 4
18 Antihypertensive Agents Phase 4
19 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
20 Atomoxetine Hydrochloride Phase 4
21 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
22 Antipsychotic Agents Phase 4
23 Central Nervous System Depressants Phase 4,Phase 1
24 Central Nervous System Stimulants Phase 4
25 Dopamine Agents Phase 4
26 Dopamine Antagonists Phase 4
27 Dopamine Uptake Inhibitors Phase 4
28 Psychotropic Drugs Phase 4,Phase 3,Phase 1,Phase 2
29
Serotonin Phase 4,Phase 3,Phase 1,Phase 2 50-67-9 5202
30 Serotonin Agents Phase 4,Phase 3,Phase 1,Phase 2
31 Serotonin Antagonists Phase 4
32 Tranquilizing Agents Phase 4,Phase 1
33 Antidepressive Agents Phase 4,Phase 3,Phase 1,Phase 2
34 Serotonin Uptake Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
35 Fibrinolytic Agents Phase 4
36
Paroxetine Approved, Investigational Phase 3 61869-08-7 43815
37 Antidepressive Agents, Second-Generation Phase 3
38 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
39 Cytochrome P-450 Enzyme Inhibitors Phase 3
40
Estradiol Approved, Investigational, Vet_approved Phase 2,Phase 1 50-28-2 5757
41
Drospirenone Approved Phase 2 67392-87-4 68873
42
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
43
Progesterone Approved, Vet_approved Phase 2 57-83-0 5994
44 Anesthetics Phase 2,Phase 1
45 Estradiol 17 beta-cypionate Phase 2,Phase 1
46 Estradiol 3-benzoate Phase 2,Phase 1
47 Estradiol valerate Phase 2,Phase 1 979-32-8
48 Estrogens Phase 2,Phase 1
49 Polyestradiol phosphate Phase 2,Phase 1
50 Contraceptive Agents Phase 2

Interventional clinical trials:

(show all 44)

# Name Status NCT ID Phase Drugs
1 Athena Pelvic Muscle Trainer - DUETS Trial Completed NCT01073878 Phase 4
2 Effectiveness of Flutamide in Treating Women With Premenstrual Dysphoric Disorder Completed NCT00611923 Phase 4 Flutamide;Placebo
3 Intuniv vs Placebo in the Treatment of Childhood Intermittent Explosive Disorder Completed NCT02048241 Phase 4 Intuniv
4 Atomoxetine, Placebo and Parent Management Training in Autism Completed NCT00844753 Phase 4 atomoxetine;Placebo
5 Ultrasound Plus Nerve Stimulator Versus Nerve Stimulator Guided Lumbar Plexus Block Completed NCT02020096 Phase 4
6 Treatment of Severe Childhood Aggression (The TOSCA Study) Completed NCT00796302 Phase 4 Methylphenidate HCl;Risperidone;Placebo
7 Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder Completed NCT00536198 Phase 4 Sertraline;Placebo
8 Outcome of Percutaneous Mechanical Thrombectomy to Treat Acute Deep Venous Thrombosis Recruiting NCT02959801 Phase 4
9 Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients Not yet recruiting NCT03452891 Phase 4 Simvastatin-Methylcellulose
10 Operations and Pelvic Muscle Training in the Management of Apical Support Loss: The OPTIMAL Trial Completed NCT00597935 Phase 3
11 Luteal Phase Administration of Paroxetine for the Treatment of PMDD Completed NCT00620581 Phase 3 Paroxetine
12 The Impact of Serelys PMS on Symptoms of PMS Not yet recruiting NCT03298607 Phase 3
13 Foster Teens' Risk During Transition Unknown status NCT02037750 Phase 2
14 Antidepressant Treatment for Premenstrual Syndrome and Premenstrual Dysphoric Disorder Completed NCT00048854 Phase 1, Phase 2 Sertraline
15 a Clinical Trial to Evaluate the Efficacy and Safety of Agnucaston Tablets in the Treatment of Premenstrual Syndrome (PMS) Completed NCT00672607 Phase 2 extracts of Vitex agnus castus tablets;Placebo
16 Single Session Percutaneous Mechanical Thrombectomy for the Treatment of Ilio-femoral Deep Vein Thrombosis: A Preliminary Evaluation Terminated NCT02066597 Phase 2
17 Treatment of Menstrually Related Disorders With Continuous v. Interrupted Oral Contraceptives Terminated NCT00089414 Phase 2 Ethinyl Estradiol/Drospirenone;Placebo;CDB 2914
18 Dutasteride to Treat Women With Menstrually Related Mood Disorders Completed NCT00082043 Phase 1 Dutasteride;Placebo oral capsule
19 A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Recruiting NCT01296555 Phase 1 Fulvestrant;GDC-0032;Letrozole;Midazolam
20 Deep Transcranial Magnetic Stimulation (dTMS) for the Treatment of Premenstrual Dysphoric Disorder (PMDD) Unknown status NCT02448836
21 Siblings in Foster Care Unknown status NCT01104818
22 [Trial of device that is not approved or cleared by the U.S. FDA] Withheld NCT01022554
23 Psychodynamic Motivation and Training Program Completed NCT01445808
24 Motor Threshold and Motor Cortex Stimulation Completed NCT02255643
25 Synbiotics in Advanced HIV Infection Completed NCT03009032
26 Comparison of Two Psychosocial Therapies for Treating Children With Oppositional-Defiant Disorder Completed NCT00510120
27 The Extended Operations And Pelvic Muscle Training In The Management Of Apical Support Loss Study Completed NCT01166373
28 Mobile Health Intervention in Increasing HPV Vaccine Coverage Among Young Adult Gay and Bisexual Men Completed NCT02835755
29 QuickOptTM Study - Using the QuickOptTM Method for Timing Cycle Optimization Completed NCT00918294
30 Comparison of Fluoxetine, Calcium and Placebo for the Treatment of Moderate to Severe Premenstrual Syndrome (PMS) Completed NCT00965562 Fluoxetine;Calcium;Placebo
31 A Comparison of Visualization Between Shamrock Technique and Paramedian Transverse Scan in Lumbar Plexus Blockade Completed NCT02982031
32 Using Electrocorticogram (ECoG) in Predicting Eloquent Cortex and Post-Op Functional Outcomes in Patients With Brain Tumors Recruiting NCT02754544
33 Caregiver-Guided Pain Management Training in Palliative Care Recruiting NCT02430467
34 Personalize my Treatment Recruiting NCT02355171
35 Integrated Primary Care for Chronic Lung Disease: PACK Brazil Recruiting NCT02786030
36 Integrated Primary Care for Diabetes and Cardiovascular Disease Recruiting NCT02795910
37 Pulmonary Embolism Response to Fragmentation, Embolectomy, & Catheter Thrombolysis: PERFECT Recruiting NCT01097928
38 Effect of Homeopathy, Acupuncture or Anthroposophic Medicine in Women's Quality of Life Recruiting NCT02504515
39 Effectiveness of an Intervention in Improving Medication Adherence Among Malay Patients With Underlying Type 2 Diabetes Mellitus in Malaysia Recruiting NCT03228706
40 Advanced Bradycardia Device Feature Utilization and Clinical Outcomes II Active, not recruiting NCT02577887
41 National Evaluation of Quality of Childcare Enrolling by invitation NCT02534597
42 Neuromodulation for Accidental Bowel Leakage Not yet recruiting NCT03278613
43 Evaluation of DTRAX Graft in Patients With Cervical Degenerative Disc Disease Withdrawn NCT01616719
44 Study to Compare a Fast Gama Camera for Nuclear Imaging to Conventional Camera Withdrawn NCT00979355

Search NIH Clinical Center for Premenstrual Tension

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: premenstrual syndrome

Genetic Tests for Premenstrual Tension

Anatomical Context for Premenstrual Tension

MalaCards organs/tissues related to Premenstrual Tension:

38
Breast, Bone, Cortex, Brain, Lung

Publications for Premenstrual Tension

Articles related to Premenstrual Tension:

(show top 50) (show all 202)
# Title Authors Year
1
The premenstrual tension syndrome rating scales: an updated version. ( 21802738 )
2011
2
Characterization of headaches in the premenstrual tension syndrome. ( 19330208 )
2009
3
Role of bromocriptine and pyridoxine in premenstrual tension syndrome. ( 18476391 )
2007
4
Cerazette for premenstrual tension. ( 16105314 )
2005
5
A psychoanalytical approach to premenstrual tension syndrome. ( 15194524 )
2004
6
Historical studies of premenstrual tension up to 30 years ago: implications for future research. ( 12441020 )
2002
7
Women's perceptions of phenomena they label premenstrual tension: normal experiences reflecting ordinary behaviour. ( 10520105 )
1999
8
Relationship between premenstrual tension syndrome and anxiety in Chinese adolescents. ( 9502014 )
1998
9
Treatment of premenstrual tension syndrome with Vitex agnus castus controlled, double-blind study versus pyridoxine. ( 23195474 )
1997
10
Premenstrual tension among hysterectomized women. ( 8528381 )
1995
11
Plasma copper, zinc and magnesium levels in patients with premenstrual tension syndrome. ( 8042455 )
1994
12
Ovarian suppression with the gonadotrophin-releasing hormone agonist goserelin (Zoladex) in management of the premenstrual tension syndrome. ( 7962376 )
1994
13
Premenstrual tension among nurses in Nairobi, Kenya. ( 8306911 )
1993
14
Premenstrual tension as mitigation in a criminal case. ( 1431801 )
1992
15
Premenstrual tension syndrome with periodic bulimia nervosa: report of a case and review of the literature. ( 1360302 )
1992
16
Premenstrual tension: a placebo-controlled efficacy study with spironolactone and medroxyprogesterone acetate. ( 1673942 )
1991
17
Pre-eclampsia, hypertension and the premenstrual tension syndrome. ( 1972097 )
1990
18
Assessment of the significance and severity of premenstrual tension--I. A new model. ( 2795503 )
1989
19
Danazol, premenstrual tension, and uveitis. Case report. ( 2730393 )
1989
20
Assessment of the significance and severity of premenstrual tension--II. Comparison of methods. ( 2795504 )
1989
21
Induced anovulation as treatment of premenstrual tension syndrome. A double-blind cross-over study with GnRH-agonist versus placebo. ( 3140572 )
1988
22
Impaired reception of nonverbal cues in women with premenstrual tension syndrome. ( 3230535 )
1988
23
A clinical trial using danazol for the treatment of premenstrual tension. ( 3545282 )
1987
24
Vitamin B6 (pyridoxine) and the premenstrual tension syndrome. ( 3454904 )
1987
25
Evaluation of psychiatric symptoms in patients presenting with symptoms of premenstrual tension syndrome. ( 3301138 )
1987
26
Role of nutrition in managing the premenstrual tension syndromes. ( 2956416 )
1987
27
Platelet serotonin uptake and effects of vitamin B6-treatment in premenstrual tension. ( 3330183 )
1987
28
The premenstrual tension syndromes: an update. ( 3612633 )
1987
29
Plasma beta-endorphin immunoreactivity in premenstrual tension. ( 2949774 )
1987
30
Premenstrual tension syndrome symptom clusters. Statistical evaluation of the subsyndromes. ( 3612634 )
1987
31
Premenstrual tension, expectancy, and mother-child relations. ( 3746897 )
1986
32
Premenstrual tension syndrome in rapid-cycling bipolar affective disorder. ( 2874129 )
1986
33
Diagnosing premenstrual tension syndrome. ( 3943794 )
1986
34
Comparison of depressed and nondepressed women with severe premenstrual tension syndrome. ( 3823355 )
1986
35
Pseudocholinesterase and trait anxiety in premenstrual tension syndrome. ( 4038979 )
1985
36
Prolonged follicular phase and depressed gonadotrophins following hysterectomy and corpus lute-ectomy in women with premenstrual tension syndrome. ( 3926350 )
1985
37
Cyclical mood changes as in the premenstrual tension syndrome during sequential estrogen-progestagen postmenopausal replacement therapy. ( 4061059 )
1985
38
Biochemical hypotheses of premenstrual tension syndrome. ( 2859626 )
1985
39
Hyperphagia in premenstrual tension syndrome. ( 2931423 )
1985
40
Premenstrual tension syndrome. ( 3920591 )
1985
41
No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. ( 3914180 )
1985
42
Progesterone treatment of premenstrual tension--a double blind study. ( 3906106 )
1985
43
Premenstrual tension syndrome. ( 3906055 )
1985
44
Hormonal studies in women with premenstrual tension. ( 4038882 )
1985
45
Premenstrual tension. ( 6541695 )
1984
46
The use of clonidine in premenstrual tension syndrome. ( 6542572 )
1984
47
Plasma prolactin and severe premenstrual tension. ( 6539925 )
1984
48
Circadian hormone secretory profiles in women with severe premenstrual tension syndrome. ( 6539122 )
1984
49
Premenstrual tension. ( 6542351 )
1984
50
beta-Endorphin withdrawal: a possible cause of premenstrual tension syndrome. ( 6094401 )
1984

Variations for Premenstrual Tension

Expression for Premenstrual Tension

Search GEO for disease gene expression data for Premenstrual Tension.

Pathways for Premenstrual Tension

Pathways related to Premenstrual Tension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.21 GNRH1 SHBG
2 9.47 CRH POMC

GO Terms for Premenstrual Tension

Cellular components related to Premenstrual Tension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.4 AVP CAMP CRH GNRH1 HP LIPN

Biological processes related to Premenstrual Tension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.8 AVP GNRH1 OXT POMC PRL
2 cell-cell signaling GO:0007267 9.73 AVP GNRH1 PGR POMC
3 regulation of blood pressure GO:0008217 9.54 LRP5 POMC REN
4 response to peptide hormone GO:0043434 9.33 GNRH1 LRP5 OXT
5 response to prostaglandin E GO:0034695 9.32 GNRH1 OXT
6 drinking behavior GO:0042756 9.26 OXT REN
7 response to ether GO:0045472 8.96 CRH OXT
8 female pregnancy GO:0007565 8.92 CRH GNRH1 OXT PRL

Molecular functions related to Premenstrual Tension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.26 AVP CRH OXT POMC
2 neurohypophyseal hormone activity GO:0005185 9.16 AVP OXT
3 hormone activity GO:0005179 9.1 AVP CRH GNRH1 OXT POMC PRL

Sources for Premenstrual Tension

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10 dbSNP
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16 ExPASy
18 FMA
27 GO
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30 HMDB
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32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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41 MeSH
42 MESH via Orphanet
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47 NDF-RT
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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