MCID: PRR004
MIFTS: 33

Preretinal Fibrosis

Categories: Eye diseases

Aliases & Classifications for Preretinal Fibrosis

MalaCards integrated aliases for Preretinal Fibrosis:

Name: Preretinal Fibrosis 12 14
Macular Puckering of Retina 12
Macular Retinal Puckering 12
Cellophane Maculopathy 12
Epiretinal Membrane 42

Classifications:



External Ids:

Disease Ontology 12 DOID:2006
ICD9CM 35 362.56
MeSH 42 D019773
UMLS 69 C0339543

Summaries for Preretinal Fibrosis

MalaCards based summary : Preretinal Fibrosis, also known as macular puckering of retina, is related to vitreoretinopathy, neovascular inflammatory and retinitis. An important gene associated with Preretinal Fibrosis is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are EPHA forward signaling and AGE-RAGE signaling pathway in diabetic complications. The drugs Dexamethasone and Nepafenac have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related phenotype is vision/eye.

Related Diseases for Preretinal Fibrosis

Diseases related to Preretinal Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
id Related Disease Score Top Affiliating Genes
1 vitreoretinopathy, neovascular inflammatory 10.9
2 retinitis 10.3
3 macular holes 10.3
4 vitreous detachment 10.1
5 aniseikonia 10.1
6 exudative vitreoretinopathy 1 10.1 GFAP TGFB2
7 retinal detachment 10.1
8 ulnar neuropathy 10.1 GFAP VEGFA
9 posterior foramen magnum meningioma 10.1 GFAP VEGFA
10 cataract 10.1
11 cystic lymphangioma 10.0 GFAP VEGFA
12 endotheliitis 10.0
13 congenital ichthyosiform erythroderma 10.0 TGFB2 VEGFA
14 uveitis 10.0
15 inflammatory leiomyosarcoma 9.9 GFAP VEGFA
16 malignant granular cell skin tumor 9.9 TGFB2 VEGFA
17 combined hamartoma of the retina and retinal pigment epithelium 9.9
18 coats disease 9.9
19 neuropathy, hereditary sensory and autonomic, type vi 9.9 TGFB2 VEGFA
20 prostate carcinoma in situ 9.8 GFAP VEGFA
21 diabetic macular edema 9.8
22 retinitis pigmentosa 9.8
23 refractive error 9.8
24 pars planitis 9.8
25 stargardt disease 9.8
26 cerebral artery occlusion 9.8 TGFB2 VEGFA
27 splenic sequestration 9.8 DPT LCK
28 testicular granulosa cell tumor 9.7 GFAP VEGFA
29 holoprosencephaly 9.7 TGFB2 VEGFA
30 hemangioma 9.7
31 chorioretinitis 9.7
32 retinal vein occlusion 9.7
33 neuroretinitis 9.7
34 myotonic dystrophy 9.7
35 choroiditis 9.7
36 eales disease 9.7
37 duane retraction syndrome 9.7
38 pachygyria 9.7
39 hypoxia 9.7
40 basal cell nevus syndrome 9.7
41 shaken baby syndrome 9.7
42 basal cell carcinoma 9.7
43 insulin-like growth factor i 9.7
44 neurofibromatosis, type 2 9.7
45 craniopharyngioma 9.7
46 retinoschisis 9.7
47 cavernous hemangioma 9.7
48 strabismus 9.7
49 nodular goiter 9.5 GFAP VEGFA
50 purulent endophthalmitis 9.1 GFAP RLBP1 TGFB2 VEGFA

Graphical network of the top 20 diseases related to Preretinal Fibrosis:



Diseases related to Preretinal Fibrosis

Symptoms & Phenotypes for Preretinal Fibrosis

MGI Mouse Phenotypes related to Preretinal Fibrosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 DPT GFAP RLBP1 TGFB2 VEGFA

Drugs & Therapeutics for Preretinal Fibrosis

Drugs for Preretinal Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
2
Nepafenac Approved Phase 4 78281-72-8 151075
3
Ranibizumab Approved Phase 4 347396-82-1 459903
4
Verteporfin Approved, Investigational Phase 4 129497-78-5
5
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
6
Triazolam Approved Phase 4 28911-01-5 5556
7 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Antirheumatic Agents Phase 4,Phase 3
9 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
11 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
12 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
13 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
14 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
15 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
16 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
17 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
19 Hormones Phase 4,Phase 3,Phase 2,Phase 1
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
21
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
22 Angiogenesis Inhibitors Phase 4
23 Angiogenesis Modulating Agents Phase 4
24 Anesthetics Phase 4
25 Analgesics Phase 4
26 Analgesics, Non-Narcotic Phase 4
27 Anti-Inflammatory Agents, Non-Steroidal Phase 4
28 Dermatologic Agents Phase 4
29 Photosensitizing Agents Phase 4
30 Adjuvants, Anesthesia Phase 4
31 Anesthetics, General Phase 4
32 Anesthetics, Intravenous Phase 4
33 Anti-Anxiety Agents Phase 4
34 Central Nervous System Depressants Phase 4
35 GABA Agents Phase 4
36 GABA Modulators Phase 4
37 Hypnotics and Sedatives Phase 4
38 Neurotransmitter Agents Phase 4
39 Psychotropic Drugs Phase 4
40 Tranquilizing Agents Phase 4
41
Colchicine Approved Phase 3 64-86-8 6167 2833
42
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
43
Dalteparin Approved Phase 3 9005-49-6
44
Fluorouracil Approved Phase 3 51-21-8 3385
45
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
46 Antimitotic Agents Phase 3
47 triamcinolone acetonide Phase 3
48 Triamcinolone diacetate Phase 3
49 Triamcinolone hexacetonide Phase 3
50 Anticoagulants Phase 3

Interventional clinical trials:

(show top 50) (show all 81)

id Name Status NCT ID Phase Drugs
1 Role of Nepafenac in Reducing Macular Volume After Epiretinal Membrane Surgery Completed NCT00818844 Phase 4 Nepafenac 0.1%
2 Ozurdex for Diabetic Macular Edema Treated With Pars Plana vitrEctomy and Membrane RemovAl (OPERA Study) Completed NCT01613716 Phase 4 Ozurdex
3 Cohort Study of the Clinical Course of Macular Diseases in Kagawa Recruiting NCT02321267 Phase 4 ranibizumab, aflibercept, pegaptanib, verteporphin
4 Oral Versus Intravenous Sedation for Ocular Procedures Recruiting NCT03246724 Phase 4 Triazolam;Midazolam;Microcrystalline Cellulose;Sodium chloride 0.9%
5 Brilliant Blue Versus Indocyanine Green Unknown status NCT01083004 Phase 3
6 Safety and Efficacy of Double Staining With Brilliant Blue G for Macular Surgery Unknown status NCT01820520 Phase 3 brilliant blue G
7 Efficacy of Oral Colchicine in Prevention of Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment Unknown status NCT00370201 Phase 3 colchicine
8 Surgical Management of Pseudophakic and Aphakic Retinal Detachment; a Randomized Clinical Trial Unknown status NCT00370279 Phase 3
9 Oral Colchicine Combined With Intravitreal Infusion of Dexamethasone, LMW Heparin and 5-FU for Management of Proliferative Vitreoretinopathy (PVR) Unknown status NCT00370760 Phase 3 oral colchicine, dexamethasone, low molecular weight heparin, 5-FU;placebo
10 Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy Completed NCT01627977 Phase 3
11 Ozurdex for Macular Edema Post Membrane Peeling Completed NCT01273727 Phase 2, Phase 3 Dexamethasone;dexamethasone
12 Pars Plana Vitrectomy for Diabetic Fibrovascular Proliferation With and Without Internal Limiting Membrane Peeling Unknown status NCT00556244 Phase 1, Phase 2
13 Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal Terminated NCT00333060 Phase 2 OT-551 ophthalmic solution
14 PK Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Patients Undergoing Vitrectomy Completed NCT02644694 Phase 1 Dexamethasone Phosphate Ophthalmic Solution
15 Change in Foveal Avascular Zone After Removal of Epiretinal Membrane and Internal Limiting Membrane Unknown status NCT01985490
16 Outcomes of Vitrectomy Combined With Subtenon Triamcinolone Injection for the Idiopathic Epiretinal Membrane Unknown status NCT01630876
17 Study of Retinal Sensitivity by Microperimetry During Epiretinal Membrane Surgery Unknown status NCT02084212
18 Gene Expression in Patients With Epiretinal Membranes Unknown status NCT01946451
19 Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel Unknown status NCT00892619
20 Comparison of Postoperative Aqueous Flare After 20G Versus 23G Pars Plana Vitrectomy Unknown status NCT01969929
21 Prophylactic Laser Photocoagulation and Vitrectomy for Acute Retinal Necrosis Unknown status NCT02222857
22 Triple Therapy for Diffuse Diabetic Macular Edema Unknown status NCT01218750
23 Retinal Neurodegenerative Signs in Alzheimer's Diseases Unknown status NCT01555827
24 Microperimetry and Optical Coherence Tomography (OCT) in Idiopathic Epiretinal Membrane Completed NCT01481987
25 Study of Impact of Air vs SF6 20% on Visual Acuity Improvement After Epiretinal Membrane Stripping Completed NCT02030262
26 Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal Completed NCT01474655
27 Phacoemulsification and 25 Gauge (25G) Vitrectomy Versus Phacoemulsification Only in Idiopathic Epiretinal Membranes Completed NCT01771939
28 Fundus Autofluorescence After Vitrectomy for Epiretinal Membrane Completed NCT02628158
29 Surgical Removal of Idiopathic Epiretinal Membrane With and Without the Assistance of Indocyanine Green. Completed NCT00376857 Surgery with and without the aid of Indocyanine Green (ICG)
30 Topical Use of Corticosteroid to Prevent Epiretinal Membrane Following Retinal Tear Completed NCT02412059 Prednisolone acetate
31 Trypan Blue Versus Brillant Blue for Epiretinal Membranes Completed NCT00757380
32 Mid-term Evaluation of Metamorphopsia in Epiretinal Membrane Surgery Completed NCT03045367
33 Evaluation of the Cone Outer Segment Tips Line After Epiretinal Membrane Surgery Completed NCT01549249
34 Refractive Consequences of Epiretinal Membrane Surgery Completed NCT02413619
35 Treatment of Epiretinal Membranes With Ranibizumab Completed NCT01238393 intravitreal ranibizumab
36 Prognostic Factors in Epiretinal Membrane Surgery Completed NCT02406430
37 Prophylactic Ketorolac Post Epiretinal Membrane Surgery Completed NCT00974753 Ketorolac 0.5%
38 Intravitreal Anti-VEGF in Exudative AMD With Epiretinal Membranes Completed NCT01846351
39 Change of Retinally-Induced Aniseikonia in Patients With Epiretinal Membrane After Vitrectomy Completed NCT01901406
40 UHR-OCT and HD-OCT for Preretinal Membranes: ICG Versus Membrane Blue Completed NCT00437593
41 27-gauge Vitrectomy Wound Integrity: a Prospective, Randomized Trial Comparing Angled Versus Straight Entry Completed NCT02836210
42 Epiretinal Fibrosis, Effect of Early Surgery Completed NCT00902629
43 Membrane Blue Versus Infracyanine Green Completed NCT00555269
44 Vitrectomy Retinal Oxygenation Completed NCT01510691
45 Applicability of the Acai Fruit (Euterpe Oleracea) Dye for Chromovitrectomy in Humans Completed NCT02691429
46 Blue-Blocking IOLs in Combined Surgery Completed NCT00537992
47 Clinicopathologic Findings for Macular Disease Completed NCT00994227
48 Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies Completed NCT00408720
49 Eye Injections of Bevacizumab for Lowering Risk of Scar Tissue in the Retina and Repeated Retinal Detachment. Completed NCT01860586 Bevacizumab
50 Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) Study Completed NCT01162356

Search NIH Clinical Center for Preretinal Fibrosis

Cochrane evidence based reviews: epiretinal membrane

Genetic Tests for Preretinal Fibrosis

Anatomical Context for Preretinal Fibrosis

MalaCards organs/tissues related to Preretinal Fibrosis:

39
Retina, Eye, Endothelial

Publications for Preretinal Fibrosis

Articles related to Preretinal Fibrosis:

id Title Authors Year
1
Idiopathic preretinal fibrosis: a review of 237 cases. ( 1549286 )
1992
2
Idiopathic preretinal fibrosis with concurrent cystoid macular edema. ( 3429756 )
1987
3
Idiopathic preretinal fibrosis in young patient. ( 3842950 )
1985

Variations for Preretinal Fibrosis

Expression for Preretinal Fibrosis

Search GEO for disease gene expression data for Preretinal Fibrosis.

Pathways for Preretinal Fibrosis

GO Terms for Preretinal Fibrosis

Cellular components related to Preretinal Fibrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 8.65 RLBP1
2 platelet alpha granule lumen GO:0031093 8.62 TGFB2 VEGFA

Biological processes related to Preretinal Fibrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.43 TGFB2 VEGFA
2 kidney development GO:0001822 9.4 TGFB2 VEGFA
3 hemopoiesis GO:0030097 9.37 LCK TGFB2
4 activation of protein kinase activity GO:0032147 9.26 TGFB2 VEGFA
5 heart morphogenesis GO:0003007 9.16 TGFB2 VEGFA
6 response to wounding GO:0009611 9.02 TGFB2
7 positive regulation of cell division GO:0051781 8.96 TGFB2 VEGFA
8 collagen fibril organization GO:0030199 8.62 DPT TGFB2

Sources for Preretinal Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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