Aliases & Classifications for Presbyopia

MalaCards integrated aliases for Presbyopia:

Name: Presbyopia 12 72 41 14 69 59

Classifications:



External Ids:

Disease Ontology 12 DOID:11638
ICD10 32 H52.4
ICD9CM 34 367.4
MeSH 41 D011305
SNOMED-CT 64 155135005 41256004
UMLS 69 C0033075

Summaries for Presbyopia

PubMed Health : 59
About presbyopia: It happens to all of us eventually: You have to start holding newspapers or books further away in order to be able to read them and clearly recognize letters without straining your eyes.Seeing nearby objects less clearly is a normal part of aging. Known as presbyopia, this typically becomes noticeable in your mid-forties.Although there are no effective treatments for the causes of presbyopia, the effects can be corrected. The best and easiest way to do so is using reading glasses.

MalaCards based summary : Presbyopia is related to cycloplegia and cataract, and has symptoms including aniseikonia An important gene associated with Presbyopia is CRYAA (Crystallin Alpha A). The drugs Dipivefrin and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, breast and testes.

Wikipedia : 72 Presbyopia is a condition associated with aging of the eye that results in progressively worsening... more...

Related Diseases for Presbyopia

Diseases related to Presbyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 cycloplegia 31.4 CRYAA CTSC
2 cataract 29.1 BFSP2 CRYAA CRYGS MIP
3 refractive error 11.5
4 aging 10.5
5 myopia 10.3
6 astigmatism 10.3
7 early-onset nuclear cataract 10.1 CRYAA MIP
8 retinitis 10.0
9 cataract 44 10.0 CRYAA MIP
10 nuclear senile cataract 10.0 CRYAA CRYGS
11 glass syndrome 9.9
12 blood group, i system 9.8
13 ocular dominance 9.8
14 strabismus 9.8
15 alternating exotropia 9.8
16 exotropia 9.8
17 corneal ectasia 9.8
18 amyloidosis 9.8
19 esotropia 9.8
20 monofixation syndrome 9.8
21 streptococcal group a invasive disease 9.8
22 mature cataract 9.7 CRYAA CRYGS MIP
23 lens disease 9.7 CRYAA CRYGS MIP
24 blood group, globoside system 9.6 CRYAA CRYGS
25 cataract 25 9.4 BFSP2 CRYGS MIP
26 cataract 16, multiple types 9.2 BFSP2 CRYAA CRYGS MIP
27 eye accommodation disease 7.7 BFSP2 CPNE6 CRYAA CRYGS CTSC HIVEP3

Graphical network of the top 20 diseases related to Presbyopia:



Diseases related to Presbyopia

Symptoms & Phenotypes for Presbyopia

UMLS symptoms related to Presbyopia:


aniseikonia

Drugs & Therapeutics for Presbyopia

PubMedHealth treatment related to Presbyopia: 59

Although there are no effective treatments to fight the cause of presbyopia, the effects of presbyopia are easily corrected. The easiest way to solve the problem of not being able to see nearby objects is wearing ready-made reading glasses available in shops. But these readily available reading glasses don't account for possible differences in vision between your eyes or other features, such as astigmatism (an irregularly shaped cornea). Individually adjusted prescription reading glasses are only available from an optician's, where glasses with the required lens power are made especially based on the results of an eye test. The distance between the pupils of your eyes and other factors are also taken into account. Reading glasses are often narrow enough for you to be able to look over them if you want to see things that are further away.If you already wore prescription glasses before presbyopia started becoming an issue, multifocals are an option. Bifocal glasses (bifocals) are one type of multifocal glasses. They have two zones divided in the middle by a visible horizontal line. The lower half of the glasses is for looking at nearby objects, and the upper half is for looking at objects that are further away. Trifocals have a visibly separate third zone for seeing objects at intermediate distances too. In varifocals (also known as progressive lenses), the lines dividing the different zones have been smoothly polished so you can’t see them. They are the most common kind of glasses.

Drugs for Presbyopia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4 52365-63-6 3105
2 Alkylating Agents Phase 4
3 Anti-Bacterial Agents Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Mitomycins Phase 4
6 Nucleic Acid Synthesis Inhibitors Phase 4
7 Vitamins Phase 4
8 Omega 3 Fatty Acid Nutraceutical Phase 4
9
Tropicamide Approved, Investigational Phase 2 1508-75-4 5593
10 Ophthalmic Solutions Phase 1, Phase 2
11 Pharmaceutical Solutions Phase 1, Phase 2
12
Dopamine Approved 51-61-6, 62-31-7 681
13
Menthol Approved 2216-51-5 16666
14
Methamphetamine Approved, Illicit 537-46-2 10836
15
Meclocycline Approved, Investigational 2013-58-3 5480760
16
Pilocarpine Approved, Investigational 92-13-7, 54-71-7 5910
17
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
18
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
19
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
20 Adrenergic Agents
21 Autonomic Agents
22 Central Nervous System Stimulants
23 Dopamine Agents
24 Dopamine Uptake Inhibitors
25 Neurotransmitter Agents
26 Neurotransmitter Uptake Inhibitors
27 Peripheral Nervous System Agents
28 Cholinergic Agents
29 Tetrahydrozoline
30 Anti-Infective Agents
31 Contact Lens Solutions
32 Disinfectants
33 Anesthetics
34 Antifungal Agents
35 Dermatologic Agents
36 Keratolytic Agents
37 Polymethyl Methacrylate
38 Tea Nutraceutical

Interventional clinical trials:

(show top 50) (show all 127)

# Name Status NCT ID Phase Drugs
1 A Prospective Safety and Effectiveness Study of a New High Repetition Rate Excimer Laser Using LASIK for the Correction of Ammetropia and Presbyopia Unknown status NCT02112968 Phase 4
2 Prospective Investigation of SUPRACOR Visual Outcomes of Presbyopic Hyperopic Patients With and Without Astigmatism Unknown status NCT01628146 Phase 4
3 A Prospective Safety and Effectiveness Study of the 500 Hz Technolas Perfect Vision Excimer Laser in Asian Eyes Using LASIK Unknown status NCT01977807 Phase 4
4 Presbyopia-Correcting Intraocular Lenses (IOLs) Completed NCT00963560 Phase 4
5 A Comparison of Visual Function After Bilateral Implantation of Presbyopia-correcting Intraocular Lenses (IOLs) Completed NCT01166971 Phase 4
6 Clinical Evaluation of Biofinity Multifocal Compared With Air Optix Aqua Multifocal and With PureVision Multifocal Completed NCT01591499 Phase 4
7 Presbyopic Supracor Treatment for Near Myopic/Hyperopic Pseudophakic Eyes Completed NCT01387360 Phase 4
8 Evaluation of the Tecnis™ Multifocal and Crystalens™ Accommodating Intraocular Lenses Completed NCT01061281 Phase 4
9 Comparison of Postoperative Visual Acuity and Spectacle Independence Between the Tecnis Multifocal Intraoculer Lens (IOL) and the Crystalens Accommodating IOL Completed NCT01275118 Phase 4
10 Visual Performance After RESTOR Implantation Completed NCT01065064 Phase 4
11 A Study to Evaluate the Raindrop Near Vision Inlay Under Flap or Within Pocket Recruiting NCT03376412 Phase 4
12 A Study Raindrop Near Vision Inlay in Presbyopes Implanted in Corneal Pockets Recruiting NCT03326869 Phase 4
13 A Prospective Study to Evaluate the Raindrop Near Vision Inlay With Mitomycin C Recruiting NCT03242317 Phase 4 Mitomycin C
14 A Prospective Study to Evaluate the Raindrop Near Vision Inlay in Presbyopic Patients With Treatments to Optimize the Ocular Surface Before Implantation Recruiting NCT03126877 Phase 4 Mitomycin C
15 A Prospective Study To Evaluate The Raindrop Near Vision Inlay In Presybopic or Pseudophakic Patients Treated With Mitomycin C Following Femtosecond Flap Creation. Terminated NCT03101501 Phase 4 Mitomycin c
16 LaserACE® Procedure Restore Visual Function and Range of Accommodation LaserACE® Procedure Unknown status NCT01491360 Phase 3
17 SUPRACOR for Myopia and Myopic Astigmatism Unknown status NCT01404884 Phase 3
18 Intrastromal Correction of Ametropia by a Femtosecond Laser Unknown status NCT00928122 Phase 3
19 Intrastromal Presbyopia Correction by Means of a Femtosecond Laser Completed NCT01025050 Phase 3
20 Multicenter Evaluation of Safety and Effectiveness of Presbyopic LASIK for Hyperopes Completed NCT00910403 Phase 3
21 A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near Vision in Presbyopic Patients Completed NCT01373580 Phase 3
22 Safety and Efficacy Study to Evaluate the Treatment of Both Near and Distance Vision in a Simultaneous Laser Procedure Completed NCT01322919 Phase 3
23 A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near and Intermediate Vision in Pseudophakic Presbyopic Subjects Recruiting NCT02668523 Phase 3
24 Clinical Evaluation of the Lenstec SBL-3 Multifocal Intraocular Lens Recruiting NCT02487160 Phase 2, Phase 3
25 Evaluation of the FluidVision Accommodating Lens Active, not recruiting NCT02049567 Phase 2, Phase 3
26 Evaluation of the FluidVisionTM AIOL With an Improved Injector Active, not recruiting NCT02418871 Phase 3
27 Investigation of the Presbia Flexivue Microlens™ Active, not recruiting NCT02110472 Phase 3
28 Randomized Clinical Trial of Bifocal Lenses Versus Computer-specific Progressive Addition Lenses Terminated NCT00585026 Phase 3
29 A Study to Evaluate the Safety and Efficacy of EV06 Ophthalmic Solution in Improving Vision in Subjects With Presbyopia Completed NCT02516306 Phase 1, Phase 2 EV06 Ophthalmic Solution;Placebo Ophthalmic Solution
30 A Safety, Efficacy and Pharmacokinetic Study of AGN-199201 and AGN-190584 in Patients With Presbyopia Completed NCT02780115 Phase 2 AGN-199201 ophthalmic solution;AGN-190584 ophthalmic solution;AGN-199201 Vehicle;AGN-190584 Vehicle
31 A Study of the Concurrent Use of AGN-190584 and AGN-199201 in Participants With Presbyopia Completed NCT02595528 Phase 2 AGN-199201 ophthalmic solution;AGN-190584 ophthalmic solution;AGN-190584 vehicle;AGN-199201 + AGN-190584 Combination;AGN-199201 vehicle
32 Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Completed NCT02554396 Phase 2 PRX-100;Placebo
33 Safety and Efficacy of AGN-199201 and AGN-190584 in Patients With Presbyopia Completed NCT02197806 Phase 2 AGN-199201;AGN-190584;AGN-199201 Vehicle
34 Safety, Tolerability, and Efficacy of PresbiDrops (CSF-1), a Topical Ophthalmic Drug for Presbyopia Completed NCT02745223 Phase 2 PresbiDrops (CSF-1);Placebo
35 Safety, Tolerability and Efficacy of PresbiDrops (CSF-1) in Presbyopic Subjects Completed NCT02965664 Phase 2 PresbiDrops (CSF-1);Placebo
36 A Single-Center, Double-Masked Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Recruiting NCT03201562 Phase 2 PRX-100;PRX-100 Component #1;PRX-100 Vehicle
37 Presbyopia Compensation: Looking for Electrophysiological Predictors Unknown status NCT02444130
38 Clinical Efficacy of the Pinhole Soft Contact Lenses for Correcting Presbyopia Unknown status NCT02612584
39 Functional and Physiological Changes Induced by Pinhole Glasses in Presbyopia Unknown status NCT02722291
40 The Effect of Cataract Extraction on the Contractility of Ciliary Muscle Unknown status NCT00624039
41 Functional Assessment of Activities of Daily Living (ADL) in Patients Who Underwent Mini-monovision Correction Unknown status NCT02431156
42 Visual and Economic Profits of ReSTOR® Multifocal Intraocular Lenses (IOL) on Public Health Patients in Spain Unknown status NCT01088282
43 Clinical Evaluation of a Progressive Addition Lens (PAL) Unknown status NCT01443585
44 Mix and Match Study of Two Multifocal Intraocular Lens With Different Add Power Unknown status NCT02556944
45 Development of a Validated Chart for Intermediate Vision Assessment Unknown status NCT02279446
46 Study to Evaluate the Clinical Performance of SynergEyes A2 Hybrid Contact Lenses Unknown status NCT01058629
47 Presbyopia Screening by Community Health Worker in Bangladesh Completed NCT03001258
48 The VEPRO Trial: A Cross-Over Randomised Controlled Trial Comparing 2 Corrective Lenses for Patients With Presbyopia Completed NCT00635115
49 Investigation of AcrySof® IQ PanOptix™ Presbyopia-Correcting Intraocular Lens (IOL) Model TFNT00 Completed NCT02529488
50 PROductivity Study of Presbyopia Elimination in Rural-dwellers (PROSPER) Completed NCT03228199

Search NIH Clinical Center for Presbyopia

Cochrane evidence based reviews: presbyopia

Genetic Tests for Presbyopia

Anatomical Context for Presbyopia

MalaCards organs/tissues related to Presbyopia:

38
Eye, Breast, Testes, Cortex

Publications for Presbyopia

Articles related to Presbyopia:

(show top 50) (show all 458)
# Title Authors Year
1
Prevalence of refractive error, presbyopia, and unmet need of spectacle coverage in a northern district of Bangladesh: Rapid Assessment of Refractive Error study. ( 28976783 )
2018
2
Pupil size stability of the cubic phase mask solution for presbyopia. ( 29297211 )
2018
3
Fundamentals of Presbyopia: visual processing and binocularity in its transformation. ( 29417087 )
2018
4
Biological corneal inlay for presbyopia derived from small incision lenticule extraction (SMILE). ( 29382905 )
2018
5
Presbyopia monovision correction and cortical adaptation. ( 29152742 )
2018
6
Prevalence and incidence of presbyopia in urban Southern China. ( 29367202 )
2018
7
Optimal Keratoplasty for the Correction of Presbyopia and Hypermetropia. ( 28484647 )
2017
8
Review of Static Approaches to Surgical Correction of Presbyopia. ( 29090052 )
2017
9
Short-term visual outcome after unilateral implantation of a trifocal diffractive presbyopia-correcting intraocular lens. ( 28889556 )
2017
10
Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy. ( 28754903 )
2017
11
Bifocal nondiffractive intraocular lens forA enhanced depth of focus in correcting presbyopia: Clinical evaluation. ( 28602323 )
2017
12
Visual performance after bilateral implantation of 2 new presbyopia-correcting intraocular lenses: Trifocal versus extended range of vision. ( 28732606 )
2017
13
Monovision Versus Multifocality for Presbyopia: Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( 28674958 )
2017
14
Correcting presbyopia: the problem of pupil size. ( 28030880 )
2017
15
Corneal Refractive Procedures for the Treatment of Presbyopia. ( 28553423 )
2017
16
Simulation of commercial vs theoretically optimised contact lenses for presbyopia. ( 28439978 )
2017
17
A systematic review of pseudophakic monovision for presbyopia correction. ( 28730093 )
2017
18
Ciliary Muscle Electrostimulation to Restore Accommodation in Patients With Early Presbyopia: Preliminary Results. ( 28880331 )
2017
19
A Novel Laser Refractive Surgical Treatment for Presbyopia: Optics-Based Customization for Improved Clinical Outcome. ( 28608800 )
2017
20
Monovision LASIK Versus Presbyopia-Correcting IOLs: Comparison of Clinical and Patient-Reported Outcomes. ( 29117414 )
2017
21
Design of see-through near-eye display for presbyopia. ( 28437967 )
2017
22
Vision improvement in pilots with presbyopia following perceptual learning. ( 29154795 )
2017
23
Virtual Issue Editorial: Presbyopia - grappling with an age-old problem. ( 29044672 )
2017
24
Small incision lenticule extraction (SMILE) monovision for presbyopia correction. ( 29148031 )
2017
25
Refraction during incipient presbyopia: The Aston Longitudinal Assessment of Presbyopia (ALAP) study. ( 28599911 )
2017
26
Awareness of Presbyopia among Rural Female Population in North Karnataka. ( 29207744 )
2017
27
The Quest for Spectacle Independence: A Comparison of Multifocal Intraocular Lens Implants and Pseudophakic Monovision for Patients with Presbyopia. ( 27792408 )
2017
28
Diffractive corneal inlay for presbyopia. ( 28635120 )
2017
29
Presbyopia correction after previous refractive laser and cataract surgery: September consultation #1. ( 28991622 )
2017
30
Intracorneal Inlays for the Correction of Presbyopia. ( 28617724 )
2017
31
Monovision by Implantation of Posterior Chamber Phakic Intraocular Lens with a Central Hole (Hole ICL) for Early Presbyopia. ( 28900204 )
2017
32
Non-lens-based surgical techniques for presbyopia correction. ( 28624312 )
2017
33
One-Year Clinical Outcomes of a Corneal Inlay for Presbyopia. ( 28445192 )
2017
34
Re: Whitman etA al.: Treatment of presbyopia in emmetropes using a shape-changing corneal inlay: one-year clinical outcomes (Ophthalmology 2016;123:466-75). ( 27871403 )
2016
35
Keratectasia After Presbyopia Treatment With INTRACOR. ( 27755289 )
2016
36
Six-month visual outcomes for the correction of presbyopia using a small-aperture corneal inlay: single-site experience. ( 27843289 )
2016
37
Finding routes towards understanding and the successful correction of presbyopia. ( 27863717 )
2016
38
Presbyopia and near spectacle correction coverage among public school teachers in Ifo Township, South-West Nigeria. ( 27623724 )
2016
39
Compensation of Presbyopia With the Light Sword Lens. ( 28002561 )
2016
40
Multifocal corneal ablation (Supracor) in hyperopic presbyopia: 1-year results in a cross-sectional study. ( 28009399 )
2016
41
Presbyopia compensation: looking for cortical predictors. ( 27107029 )
2016
42
Pharmacological Treatment of Presbyopia by Novel Binocularly Instilled Eye Drops: A Pilot Study. ( 27168149 )
2016
43
Protein Disulfide Levels and Lens Elasticity Modulation: Applications for Presbyopia. ( 27233034 )
2016
44
Evaluating Three Different Methods of Determining Addition in Presbyopia. ( 27621785 )
2016
45
Population-based study of presbyopia in Nicaragua. ( 27397616 )
2016
46
Causes and correction of dissatisfaction after implantation of presbyopia-correcting intraocular lenses. ( 27784985 )
2016
47
Clinical outcomes of combined versus separate carbachol and brimonidine drops in correcting presbyopia. ( 27981057 )
2016
48
Treatment of Presbyopia in Emmetropes Using a Shape-Changing Corneal Inlay: One-Year Clinical Outcomes. ( 26804761 )
2016
49
Near vision examination in presbyopia patients: Do we need good homologated near vision charts? ( 27844022 )
2016
50
Patient experience of laser in situ keratomileusis and monocular small-aperture corneal inlay implantation for the surgical compensation of presbyopia and additional ametropia. ( 27059801 )
2016

Variations for Presbyopia

Expression for Presbyopia

Search GEO for disease gene expression data for Presbyopia.

Pathways for Presbyopia

GO Terms for Presbyopia

Biological processes related to Presbyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.33 BFSP2 CRYAA MIP
2 lens development in camera-type eye GO:0002088 8.96 CRYGS MIP
3 visual perception GO:0007601 8.8 BFSP2 CRYAA MIP

Molecular functions related to Presbyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.92 BFSP2 CRYAA CRYGS MIP

Sources for Presbyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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