MCID: PRS025
MIFTS: 30

Presbyopia malady

Eye diseases category

Summaries for Presbyopia

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Sources:
63Wikipedia, 32MalaCards
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Wikipedia:63 Presbyopia is a condition where, with age, the eye exhibits a progressively diminished ability to focus... more...

MalaCards: Presbyopia is related to cataract and refractive error. An important gene associated with Presbyopia is CRYAA (crystallin, alpha A), and among its related pathways is Non-integrin membrane-ECM interactions. Affiliated tissues include eye, cortex and testes.

Aliases & Classifications for Presbyopia

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

presbyopia 8 10 60


External Ids:

Disease Ontology8 DOID:11638
ICD9CM27 367.4
SNOMED-CT56 41256004, 155135005
MeSH34 D011305
ICD1025 H52.4

Related Diseases for Presbyopia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Presbyopia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1cataract30.6CRYAA
2refractive error10.5
3astigmatism10.4
4myopia10.4
5retinitis10.1
6epidermolysis bullosa10.0LAMA3
7senile cataract10.0LAMA3, CRYAA
8dermatomyositis10.0FBN1
9glaucoma10.0LAMA3, FBN1
10myopia 610.0LAMA3, FBN1
11alternating exotropia9.9
12monofixation syndrome9.9
13amyloidosis9.9
14corneal deposit9.9
15esotropia9.9
16exotropia9.9
17eye disease9.9
18strabismus9.9

Graphical network of diseases related to Presbyopia:



Diseases related to presbyopia

Clinical Features for Presbyopia

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Drugs & Therapeutics for Presbyopia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Presbyopia

Search NIH Clinical Center for Presbyopia

Search CenterWatch for Presbyopia

Genetic Tests for Presbyopia

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Anatomical Context for Presbyopia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Presbyopia:

32
Eye, Cortex, Testes

Animal Models for Presbyopia or affiliated genes

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Publications for Presbyopia

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Sources:
50PubMed
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Articles related to Presbyopia:

(show top 50)    (show all 350)
idTitleAuthorsYear
1
Developments in the correction of presbyopia I: spectacle and contact lenses. (24205890)
2014
2
One-year safety and efficacy results of a hydrogel inlay to improve near vision in patients with emmetropic presbyopia. (23446012)
2013
3
Supracor hyperopia and presbyopia correction: 6-month results. (24057937)
2013
4
Correcting Indigenous Australians' refractive error and presbyopia. (23009089)
2013
5
Visual outcomes and safety of a refractive corneal inlay for presbyopia using femtosecond laser. (23311737)
2013
6
Uncorrected refractive error and presbyopia among junior high school teachers in Jakarta, Indonesia. (24168702)
2013
7
Prospective evaluation of visual outcomes with three presbyopia-correcting intraocular lenses following cataract surgery. (24092961)
2013
8
Meta-analysis of sex differences in presbyopia. (22531698)
2012
9
One-year visual outcomes and patient satisfaction after surgical correction of presbyopia with an intracorneal inlay of a new design. (22138501)
2012
10
Intrastromal femtosecond laser presbyopia correction: 1-year results of a multicenter study. (22373032)
2012
11
Patterns of refractive change in myopic subjects during the incipient phase of presbyopia: a preliminary study. (21410500)
2011
12
Prandial presbyopia. (20182206)
2010
13
Visual outcomes of LASIK-induced monovision in myopic patients with presbyopia. (20542487)
2010
14
Comparison of different presbyopia treatments: refractive lens exchange with multifocal intraocular lens implantation versus LASIK monovision. (21302708)
2010
15
LASIK for hyperopic astigmatism and presbyopia using micro-monovision with the Carl Zeiss Meditec MEL80 platform. (19244952)
2009
16
Comparison of near visual acuity and reading metrics in presbyopia correction. (19631128)
2009
17
Extended depth of focus contact lenses for presbyopia. (19823554)
2009
18
Corneal multifocality with excimer laser for presbyopia correction. (19537363)
2009
19
Presbyopia-correcting intraocular lenses: what retinal surgeons should know. (18398353)
2008
20
Correction of refractive error and presbyopia in Timor-Leste. (17576709)
2007
21
Presbyopia: perspective on the reality of pseudoaccommodation with LASIK. (16500528)
2006
22
A population-based assessment of presbyopia in the state of Andhra Pradesh, south India: the Andhra Pradesh Eye Disease Study. (16723440)
2006
23
Conductive keratoplasty for presbyopia: 1-year results. (16523831)
2006
24
Multifocal IOLs for presbyopia. (16105572)
2005
25
Accommodation, presbyopia, and the lenticular syneretic response. (16282126)
2005
26
Presbyopia case study. Eye series-20. (15532161)
2004
27
Treatment of presbyopia with conductive keratoplasty: six-month results of the 1-year United States FDA clinical trial. (15448490)
2004
28
PI monovision for presbyopia. (15320858)
2004
29
The effect of incipient presbyopia on the correspondence between accommodation and vergence. (12107517)
2002
30
Presbyopia, accommodation, and mature catenary. (12153784)
2002
31
Aging of the human crystalline lens and presbyopia. (11290918)
2001
32
Scleral expansion surgery for presbyopia. (11733251)
2001
33
Centered vs. inferior off-center ablation to correct hyperopia and presbyopia. (9987728)
1999
34
Scleral expansion surgery does not restore accommodation in human presbyopia. (10328383)
1999
35
Novel approaches to correction of presbyopia with laser modification of the crystalline lens. (9574744)
1998
36
Assessment of vergence facility in a sample of older adults with presbyopia. (9848836)
1998
37
An objective and subjective comparative analysis of diffractive and front surface aspheric contact lens designs used to correct presbyopia. (8149568)
1994
38
Pathophysiology of accommodation and presbyopia. Understanding the clinical implications. (8046368)
1994
39
Contrast sensitivity with contact lens corrections for presbyopia. (2622648)
1989
40
The path to presbyopia: straight or crooked? (2631011)
1989
41
Presbyopia in light of accommodation. (3044127)
1988
42
Lack of reading interest secondary to presbyopia. (3186181)
1988
43
Presbyopia: an animal model and experimental approaches for the study of the mechanism of accommodation and ocular ageing. (3308526)
1987
44
The development of presbyopia in primates. (6964274)
1982
45
PRESBYOPIA. (18170829)
1962
46
Correction of presbyopia. (13017564)
1953
47
The management of early presbyopia. (13033911)
1953
48
Refraction with special reference to presbyopia. (20272674)
1947
49
Accommodation of presbyopia and its correction. (21012364)
1945
50
Changes in Refraction with Presbyopia. (16692861)
1930

Genetic Variations for Presbyopia

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Expression for genes affiliated with Presbyopia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Presbyopia

Search GEO for disease gene expression data for Presbyopia.

Pathways for genes affiliated with Presbyopia

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Sources:
53Reactome, 29KEGG
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Pathways related to Presbyopia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.5LAMA3, FBN1

Compounds for genes affiliated with Presbyopia

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GO Terms for genes affiliated with Presbyopia

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16Gene Ontology
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Cellular components related to Presbyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:0056049.2LAMA3, FBN1
2extracellular spaceGO:0056158.5LEFTY1, FBN1, UCN2

Biological processes related to Presbyopia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of gene expressionGO:0106299.4CRYAA, UCN2

Products for genes affiliated with Presbyopia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Presbyopia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet