MCID: PRT082
MIFTS: 46

Preterm Premature Rupture of the Membranes malady

Categories: Genetic diseases

Aliases & Classifications for Preterm Premature Rupture of the Membranes

Aliases & Descriptions for Preterm Premature Rupture of the Membranes:

Name: Preterm Premature Rupture of the Membranes 54 29
Preterm Premature Rupture of the Membranes, Susceptibility to 13

Characteristics:

HPO:

32
preterm premature rupture of the membranes:
Inheritance polygenic inheritance


Classifications:



External Ids:

OMIM 54 610504

Summaries for Preterm Premature Rupture of the Membranes

OMIM : 54 Preterm premature rupture of the membranes is defined as rupture of membranes before 37 weeks of gestation, which... (610504) more...

MalaCards based summary : Preterm Premature Rupture of the Membranes, also known as preterm premature rupture of the membranes, susceptibility to, is related to mosaic variegated aneuploidy syndrome 2 and oculomotor nerve paralysis, and has symptoms including premature rupture of membranes An important gene associated with Preterm Premature Rupture of the Membranes is SERPINH1 (Serpin Family H Member 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and Jak-STAT signaling pathway (KEGG). The drugs Dinoprostone and Misoprostol have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and colon, and related phenotypes are homeostasis/metabolism and neoplasm

Related Diseases for Preterm Premature Rupture of the Membranes

Diseases related to Preterm Premature Rupture of the Membranes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Related Disease Score Top Affiliating Genes
1 mosaic variegated aneuploidy syndrome 2 10.2 MMP1 MMP8
2 oculomotor nerve paralysis 10.2 CXCL8 IL6
3 common peroneal nerve lesion 10.2 CXCL8 IL6
4 chronic diarrhea due to guanylate cyclase 2c overactivity 10.2 MMP1 MMP8
5 cervicitis 10.2
6 neonatal hypoxic and ischemic brain injury 10.2 CXCL8 IL6
7 thymic neuroendocrine carcinoma 10.2 CXCL8 IL6
8 psychotic disorder 10.2 CXCL8 IL6
9 schwannoma of ureter 10.2 CXCL8 IL6
10 retinal vascular disease 10.2 CXCL8 IL6
11 chorioamnionitis 10.2
12 pasteurellosis 10.2 IL6 MMP1 MMP8
13 cholera 10.2 IL6 MMP1 MMP8
14 occlusion of gallbladder 10.2 IL6 SERPINH1
15 breast abscess 10.2 IL6 MMP1 TIMP2
16 acquired thrombocytopenia 10.2 CXCL8 IL6 MMP1
17 noonan syndrome 4 10.2 MMP1 SERPINH1
18 burns 10.1 CXCL8 IL6 MMP8
19 infancy electroclinical syndrome 10.1 CXCL8 IL6 MMP8
20 retinitis pigmentosa 51 10.1 CXCL8 IL6 MMP1
21 stenosis of lacrimal sac 10.1 CXCL8 IL6 MMP8
22 renal oncocytoma 10.1 MMP1 MMP8 TIMP2
23 mixed mineral dust pneumoconiosis 10.1 CXCL8 IL6 TIMP2
24 oligohydramnios 10.1
25 fungal gastritis 10.1 CXCL8 IL6 MMP8
26 angiomyoma 10.1 MMP1 TIMP2
27 synovium cancer 10.1 CXCL8 IL6 MMP1
28 bone angioendothelial sarcoma 10.1 CXCL8 IL6 MMP1
29 cataract, total congenital 10.1 IL6 IL6R
30 labyrinthine bilateral reactive loss 10.1 CXCL8 IL6
31 nasal cavity inverting papilloma 10.1 CXCL8 MMP8
32 childhood electroclinical syndrome 10.1 CXCL8 IL6 SERPINH1
33 bullous retinoschisis 10.1 CXCL8 IL6 SERPINH1
34 larynx leiomyoma 10.1 CXCL8 IL6 SERPINH1
35 intrauterine infections 10.1
36 acute panmyelosis with myelofibrosis 10.1 CXCL8 IL6
37 neuropathy 10.1 CXCL8 IL6 SERPINH1
38 blepharochalasis 10.1 CXCL8 IL6 SERPINH1
39 spinal multifocal clear cell meningioma 10.1 CXCL8 IL6 SERPINH1
40 thymus adenosquamous carcinoma 10.1 CXCL8 IL6 MMP1
41 mixed ductal-endocrine carcinoma 10.1 IL6 MMP1 MMP8 TIMP2
42 spondylolysis 10.1 CXCL8 IL6 SERPINH1
43 autosomal recessive type iv ehlers-danlos syndrome 10.0 CXCL8 IL6 MMP1 MMP8
44 avoidant personality disorder 10.0 CXCL8 IL6 SERPINH1
45 histiocytosis 10.0 CXCL8 IL6 MMP1 MMP8
46 intratubular embryonal carcinoma 10.0 CXCL8 IL6 MMP1 MMP8
47 osteonecrosis 10.0 CXCL8 IL6 MMP1
48 saethre-chotzen syndrome 10.0 IL6 IL6R IL6ST
49 vaginitis 10.0
50 autistic disorder 9.9 CXCL8 IL6 MMP1 SERPINH1

Graphical network of the top 20 diseases related to Preterm Premature Rupture of the Membranes:



Diseases related to Preterm Premature Rupture of the Membranes

Symptoms & Phenotypes for Preterm Premature Rupture of the Membranes

Clinical features from OMIM:

610504

Human phenotypes related to Preterm Premature Rupture of the Membranes:

32
id Description HPO Frequency HPO Source Accession
1 premature rupture of membranes 32 HP:0001788

MGI Mouse Phenotypes related to Preterm Premature Rupture of the Membranes:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 IL6 IL6R IL6ST INHA INHBA MMP1
2 neoplasm MP:0002006 9.1 IL6 IL6R IL6ST INHA MMP1 MMP8

Drugs & Therapeutics for Preterm Premature Rupture of the Membranes

Drugs for Preterm Premature Rupture of the Membranes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 157)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dinoprostone Approved Phase 4,Phase 3,Phase 2,Phase 1 363-24-6 5280360
2
Misoprostol Approved Phase 4,Phase 1,Phase 2 59122-46-2 5282381
3
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 57-83-0 5994
4
Ampicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3 69-53-4 6249
5
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
6
Menthol Approved Phase 4 2216-51-5 16666
7
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-56-6 439302 53477758
8
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
9
Glucosamine Approved, Nutraceutical Phase 4 3416-24-8 439213
10 Antacids Phase 4,Phase 1,Phase 2
11 Anti-Ulcer Agents Phase 4,Phase 1,Phase 2
12 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Oxytocics Phase 4,Phase 3,Phase 1,Phase 2
14 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
15 Hormones Phase 4,Phase 3,Phase 2,Phase 1
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
17 Progestins Phase 4,Phase 3,Phase 2,Phase 1
18 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
19 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
20 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Antitubercular Agents Phase 4,Phase 3,Phase 2
22 Clindamycin palmitate Phase 4
23 Clindamycin phosphate Phase 4
24 Gentamicins Phase 4,Phase 2,Phase 3
25 Micronutrients Phase 4,Phase 3,Phase 2
26
Silicon Phase 4 7440-21-3 4082203
27 Trace Elements Phase 4,Phase 3,Phase 2
28 cefuroxime axetil Phase 4
29 insulin Phase 4
30 Insulin, Globin Zinc Phase 4
31 Mitogens Phase 4
32 Anticoagulants Phase 4
33 Antimetabolites Phase 4
34 Fibrinolytic Agents Phase 4
35 Glucuronyl glucosamine glycan sulfate Phase 4
36 Hypoglycemic Agents Phase 4
37 Hypolipidemic Agents Phase 4
38 Lipid Regulating Agents Phase 4
39 Acidophilus Nutraceutical Phase 4
40 Cranberry Nutraceutical Phase 4
41
Acetylcysteine Approved, Investigational Phase 3,Phase 1,Phase 2 616-91-1 12035
42
Cefazolin Approved Phase 3 25953-19-9 656510 33255
43
Clarithromycin Approved Phase 3 81103-11-9 84029
44
Erythromycin Approved, Vet_approved Phase 3 114-07-8 12560
45
Josamycin Approved Phase 3 16846-24-5 5282165
46
Metronidazole Approved Phase 3,Phase 2 443-48-1 4173
47
Nevirapine Approved Phase 3 129618-40-2 4463
48
Azithromycin Approved Phase 3,Phase 2 83905-01-5 55185 53477736 447043
49
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
50
Betamethasone Approved, Vet_approved Phase 2, Phase 3, Phase 1 378-44-9 9782

Interventional clinical trials:

(show top 50) (show all 168)
id Name Status NCT ID Phase
1 Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy Unknown status NCT01779193 Phase 4
2 Comparison of Misoprostol and PGE2 Gel for Induction of Labour in Women With Premature Rupture of Membranes at Term Completed NCT00355966 Phase 4
3 Comparison of Misoprostol and Prostaglandin E2 (PGE2) Gel for Induction of Labour in Premature Rupture of Membranes at Term Completed NCT00355303 Phase 4
4 Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women With Short Cervix Completed NCT00706264 Phase 4
5 Feasibility and Acceptability of the Combination of Propess and AN24 Monica for Outpatient Labour Induction (PRAM) Completed NCT01026948 Phase 4
6 Prevention of Preterm Birth in Pregnant Women at Risk Identified by Ultrasound: Evaluation of Two Treatment Strategies Completed NCT01643980 Phase 4
7 Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women With Short Cervix in Twins Completed NCT01242410 Phase 4
8 Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women After Threatened Preterm Labor(PECEP-RETARD) Completed NCT01242384 Phase 4
9 Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes Recruiting NCT02819570 Phase 4
10 The Value of Oral Micronized Progesterone in the Prevention of Spontaneous Preterm Birth Recruiting NCT02571296 Phase 4
11 Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island Recruiting NCT02904070 Phase 4
12 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
13 Oxytocin vs. Prostaglandin for Induction of Labor in Primiparas With Prelabor Rupture of Membrane and Low Bishop Not yet recruiting NCT02801227 Phase 4
14 Intrapartum Fever: Antibiotics Versus no Treatment Not yet recruiting NCT03168178 Phase 4
15 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
16 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4
17 Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery Unknown status NCT01152528 Phase 3
18 Study of a Diagnostic Device for Identifying Between Amniotic Fluid to Urine Unknown status NCT01517633 Phase 2, Phase 3
19 Vaginal Compared With Intramuscular Progesterone for Prevention of Preterm Birth in High Risk Pregnant Women Unknown status NCT02304237 Phase 3
20 Safety Study of Membrane Sweeping in Pregnancy Unknown status NCT00294242 Phase 3
21 Amnioinfusion Initiative Unknown status NCT00787163 Phase 3
22 Effect of Dianatal Obstetric Gel (Cross-linked Polyacrylic Acid) on Outcomes in Vaginal Delivery Unknown status NCT01546129 Phase 3
23 Antibiotics Study in Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3
24 Does Vitamins C and E Supplementation of After Preterm Rupture of Membranes Prolong the Duration of Latency? A Prospective Randomized Controlled Study Completed NCT01266928 Phase 3
25 Progesterone (17P, Makena®) for Prolongation of Pregnancy in Women With Preterm Rupture of the Membranes (PROM) Completed NCT01119963 Phase 2, Phase 3
26 Induction of Labor in Term Premature Rupture of Membranes: A Comparison Between Oxytocin and Dinoprostone Followed Six Hours Later by Oxytocin Completed NCT01099280 Phase 3
27 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term Completed NCT01633294 Phase 2, Phase 3
28 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3
29 Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin) Completed NCT00718705 Phase 3
30 High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention Completed NCT01355159 Phase 3
31 Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission Completed NCT00021671 Phase 3
32 Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane Recruiting NCT01503606 Phase 3
33 Treatment of ppROM With Erythromycin vs. Azithromycin Trial Recruiting NCT03060473 Phase 3
34 Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes Recruiting NCT02469519 Phase 2, Phase 3
35 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Recruiting NCT02336243 Phase 3
36 Pessary in Singleton Gestations With Short Cervix Without Prior Preterm Birth Recruiting NCT02716909 Phase 3
37 Comparison Between Amniotic Fluid Lamellar Body Count and Fetal Pulmonary Artery Doppler Indices in Predicting Fetal Lung Maturity Recruiting NCT02331199 Phase 3
38 Evaluation of the Role of Vaginal Progesterone in Prevention of Preterm Labor in Twin Gestation With Short Cervix: Randomised Controlled Trial Recruiting NCT02697331 Phase 3
39 Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth Recruiting NCT02678026 Phase 3
40 Cerclage for Singletons With Short Cervix Without Prior Preterm Birth Recruiting NCT02716922 Phase 3
41 Does Cervical Pessary Prevent Spontaneous Preterm Birth in Twin Pregnancies With Short Cervical Length? Recruiting NCT02708264 Phase 3
42 Transvaginal Ultrasound Cervical Length Screening in Singleton Pregnancy With Prior Spontaneous Preterm Birth Recruiting NCT02923973 Phase 3
43 Medico-economic Impact of Screening Atopobium Vaginae and Gardnerella Vaginalis in Molecular Biology by "Point-of-care" During Pregnancy Recruiting NCT02288832 Phase 2, Phase 3
44 Tearing of Membranes Before Birth - a Comparison Between Two Ways of Induction of Labor Pitocin Opposite Prostaglandin Active, not recruiting NCT02720978 Phase 3
45 Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis Active, not recruiting NCT00879190 Phase 2, Phase 3
46 Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Not yet recruiting NCT02939742 Phase 2, Phase 3
47 Management of Labor in Patients With Previous Cesarian Section Not yet recruiting NCT02196103 Phase 2, Phase 3
48 An RCT of a Synthetic Osmotic Cervical Dilator for Induction of Labour in Comparison to Dinoprostone Vaginal insErt Not yet recruiting NCT03001661 Phase 3
49 Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes Withdrawn NCT01556334 Phase 3
50 Cerclage for Prevention on Preterm Birth in Women With Placenta Previa Withdrawn NCT01442207 Phase 3

Search NIH Clinical Center for Preterm Premature Rupture of the Membranes

Genetic Tests for Preterm Premature Rupture of the Membranes

Genetic tests related to Preterm Premature Rupture of the Membranes:

id Genetic test Affiliating Genes
1 Preterm Premature Rupture of Membranes 29

Anatomical Context for Preterm Premature Rupture of the Membranes

MalaCards organs/tissues related to Preterm Premature Rupture of the Membranes:

39
Placenta, Testes, Colon, Cervix

Publications for Preterm Premature Rupture of the Membranes

Articles related to Preterm Premature Rupture of the Membranes:

(show top 50) (show all 141)
id Title Authors Year
1
Neonatal and maternal outcomes following midtrimester preterm premature rupture of the membranes: a retrospective cohort study. ( 26831896 )
2016
2
Diagnostic and Prognostic Value of Presepsin for Subclinical Chorioamnionitis in Pregnancies between 23-28 Week with Preterm Premature Rupture of the Membranes. ( 27994922 )
2016
3
Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes. ( 26690900 )
2016
4
Retention of cervical cerclage after preterm premature rupture of the membranes: a critical appraisal. ( 25416200 )
2015
5
Perinatal outcomes of pregnancies complicated by preterm premature rupture of the membranes before 34 weeks of gestation in a tertiary center in China: A retrospective review. ( 25787907 )
2015
6
Pilot Randomized Controlled Trial to Evaluate the Impact of Bed Rest on Maternal and Fetal Outcomes in Women with Preterm Premature Rupture of the Membranes. ( 26461925 )
2015
7
Aging of intrauterine tissues in spontaneous preterm birth and preterm premature rupture of the membranes: A systematic review of the literature. ( 26004735 )
2015
8
The influence of prolonged preterm premature rupture of the membranes on neonatal outcome of the presenting and non-presenting twin. ( 25124707 )
2014
9
Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM). ( 24680695 )
2014
10
The impact of tobacco use on preterm premature rupture of the membranes. ( 22930157 )
2013
11
The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes. ( 23536574 )
2013
12
Early planned birth may reduce neonatal sepsis compared to expectant management following preterm premature rupture of the membranes close to term. ( 23125240 )
2013
13
Maternal plasma prolidase, matrix metalloproteinases 1 and 13, and oxidative stress levels in pregnancies complicated by preterm premature rupture of the membranes and chorioamnionitis. ( 24592033 )
2012
14
Activin A and its regulatory molecules in placenta and fetal membranes of women with preterm premature rupture of the membranes associated with acute chorioamnionitis. ( 22845186 )
2012
15
Optimum mode of delivery in gestations complicated by preterm premature rupture of the membranes. ( 21854136 )
2012
16
Modulation of amniotic fluid activin-a and inhibin-a in women with preterm premature rupture of the membranes and infection-induced preterm birth. ( 21992678 )
2012
17
Correlation of myometrial thickness and the latency interval of women with preterm premature rupture of the membranes. ( 21298281 )
2011
18
Women with preterm premature rupture of the membranes do not benefit from weekly progesterone. ( 20869038 )
2011
19
Antibiotics after preterm premature rupture of the membranes. ( 21508705 )
2011
20
Amniotic fluid concentrations of soluble scavenger receptor for hemoglobin (sCD163) in pregnancy complicated by preterm premature rupture of the membranes and histologic chorioamnionitis. ( 21158489 )
2011
21
IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes. ( 21282511 )
2011
22
Precipitated egg white as a sealant for iatrogenic preterm premature rupture of the membranes. ( 19942207 )
2010
23
Influence of oligohydramnios on preterm premature rupture of the membranes at 30 to 36 weeks' gestation. ( 21176313 )
2010
24
Umbilical cord blood concentrations of IL-6, IL-8, and MMP-8 in pregnancy complicated by preterm premature rupture of the membranes and histological chorioamnionitis. ( 21196908 )
2010
25
Antibiotic therapy in preterm premature rupture of the membranes. ( 19941711 )
2009
26
Neonatal outcomes after elective delivery management of preterm premature rupture of the membranes before 34 weeks' gestation (DOMINOS study). ( 19167805 )
2009
27
The management of preterm premature rupture of the membranes near the limit of fetal viability. ( 19733274 )
2009
28
Preterm premature rupture of the membranes and genital mycoplasmas. ( 20073423 )
2009
29
Modeling the duration of the latency period after preterm premature rupture of the membranes according to maternal and pregnancy characteristics: DOMINOS study. ( 18378062 )
2008
30
Outcomes following prolonged preterm premature rupture of the membranes. ( 17660215 )
2008
31
Amniocentesis in the management of preterm premature rupture of the membranes: a retrospective cohort analysis. ( 18609359 )
2008
32
Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes. ( 18061131 )
2008
33
Transcervical intrapartum amnioinfusion for preterm premature rupture of the membranes. ( 16730113 )
2007
34
Is there a role for tocolytic therapy during conservative management of preterm premature rupture of the membranes? ( 17513934 )
2007
35
Value of vaginal fluid proinflammatory cytokines for the prediction of early-onset neonatal infection in preterm premature rupture of the membranes. ( 17523871 )
2007
36
Infection and the role of inflammation in preterm premature rupture of the membranes. ( 17448730 )
2007
37
Two- or three-dimensional ultrasonography to predict pulmonary hypoplasia in pregnancies complicated by preterm premature rupture of the membranes. ( 17191262 )
2007
38
Salivary proteinase activity: a potential biomarker for preterm premature rupture of the membranes. ( 16731078 )
2006
39
Erythrocyte aggregation is increased in preterm premature rupture of the membranes. ( 16102885 )
2006
40
Neonatal mortality and morbidity after aggressive long-term tocolysis for preterm premature rupture of the membranes. ( 16757913 )
2006
41
Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and preterm premature rupture of the membranes and subsequent cesarean delivery. ( 16260207 )
2005
42
Sonographic myometrial thickness predicts the latency interval of women with preterm premature rupture of the membranes and oligohydramnios. ( 16150272 )
2005
43
Preterm premature rupture of the membranes: current approaches to evaluation and management. ( 16125041 )
2005
44
Preterm premature rupture of the membranes: diagnosis and management. ( 15519427 )
2004
45
Outcomes after expectant management of extremely preterm premature rupture of the membranes. ( 14749657 )
2004
46
Aggressive tocolysis does not prolong pregnancy or reduce neonatal morbidity after preterm premature rupture of the membranes. ( 15284781 )
2004
47
The timing of elective delivery in preterm premature rupture of the membranes: a survey of members of the Society of Maternal-Fetal Medicine. ( 15167875 )
2004
48
Fetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathways. ( 15493713 )
2004
49
Serum homocysteine levels after preterm premature rupture of the membranes. ( 15343233 )
2004
50
Increased levels of interleukin-6 in cervical secretions and assessment of the uterine cervix by transvaginal ultrasonography predict preterm premature rupture of the membranes. ( 12576744 )
2003

Variations for Preterm Premature Rupture of the Membranes

ClinVar genetic disease variations for Preterm Premature Rupture of the Membranes:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SERPINH1 SERPINH1, -656C-T single nucleotide variant Pathogenic
2 MMP8 MMP8, HAPLOTYPE, TGG single nucleotide variant Pathogenic
3 MMP1 NM_002421.3(MMP1): c.-1673G= single nucleotide variant Pathogenic,risk factor GRCh37 Chromosome 11, 102670496: 102670496

Expression for Preterm Premature Rupture of the Membranes

Search GEO for disease gene expression data for Preterm Premature Rupture of the Membranes.

Pathways for Preterm Premature Rupture of the Membranes

Pathways related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 MMP1 MMP8 SERPINH1 TIMP2
2
Show member pathways
12.04 IL6 IL6R IL6ST
3 12.01 IL6 IL6R MMP1
4 12 CXCL8 IL6 IL6R
5
Show member pathways
11.94 IL6 IL6R IL6ST
6
Show member pathways
11.89 CXCL8 IL6 IL6R IL6ST MMP1
7
Show member pathways
11.76 IL6 IL6R IL6ST
8
Show member pathways
11.74 MMP1 MMP8 TIMP2
9 11.69 CXCL8 IL6 MMP1
10 11.68 CXCL8 IL6 IL6R MMP1
11
Show member pathways
11.66 IL6 IL6R IL6ST
12 11.63 CXCL8 IL6 MMP1
13 11.53 IL6 IL6R IL6ST
14
Show member pathways
11.53 CXCL8 IL6 IL6R IL6ST
15
Show member pathways
11.49 CXCL8 IL6 MMP1
16 11.46 CXCL8 MMP1 TIMP2
17
Show member pathways
11.42 IL6 IL6R IL6ST
18 11.31 IL6 IL6R INHBA
19
Show member pathways
11.23 IL6 IL6R IL6ST
20 11.11 CXCL8 IL6 MMP1
21 11.06 IL6 IL6R IL6ST
22 11.05 CXCL8 IL6 IL6R IL6ST INHBA
23 10.96 CXCL8 IL6 IL6R MMP1
24 10.87 IL6ST MMP1
25 10.86 CXCL8 IL6

GO Terms for Preterm Premature Rupture of the Membranes

Cellular components related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 CXCL8 IL6 INHA INHBA MMP8 SERPINH1
2 extracellular region GO:0005576 9.65 CXCL8 IL6 IL6R IL6ST INHA INHBA
3 ciliary neurotrophic factor receptor complex GO:0070110 9.26 IL6R IL6ST
4 inhibin A complex GO:0043512 9.16 INHA INHBA
5 interleukin-6 receptor complex GO:0005896 8.8 IL6 IL6R IL6ST

Biological processes related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.88 CXCL8 IL6 INHBA TIMP2
2 cytokine-mediated signaling pathway GO:0019221 9.77 IL6 IL6R IL6ST
3 cell cycle arrest GO:0007050 9.77 CXCL8 INHA INHBA
4 extracellular matrix disassembly GO:0022617 9.71 MMP1 MMP8 TIMP2
5 positive regulation of osteoblast differentiation GO:0045669 9.67 IL6 IL6R IL6ST
6 endodermal cell differentiation GO:0035987 9.61 INHBA MMP8
7 endocrine pancreas development GO:0031018 9.61 IL6 IL6R
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 IL6 IL6R IL6ST
9 negative regulation of phosphorylation GO:0042326 9.58 INHA INHBA
10 positive regulation of chemokine production GO:0032722 9.57 IL6 IL6R
11 positive regulation of leukocyte chemotaxis GO:0002690 9.56 IL6 IL6R
12 positive regulation of acute inflammatory response GO:0002675 9.55 IL6 IL6ST
13 negative regulation of macrophage differentiation GO:0045650 9.52 INHA INHBA
14 positive regulation of follicle-stimulating hormone secretion GO:0046881 9.51 INHA INHBA
15 hemoglobin biosynthetic process GO:0042541 9.48 INHA INHBA
16 ciliary neurotrophic factor-mediated signaling pathway GO:0070120 9.46 IL6R IL6ST
17 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 9.43 IL6 IL6R IL6ST
18 negative regulation of interferon-gamma biosynthetic process GO:0045077 9.4 INHA INHBA
19 negative regulation of B cell differentiation GO:0045578 9.37 INHA INHBA
20 negative regulation of follicle-stimulating hormone secretion GO:0046882 9.32 INHA INHBA
21 response to cytokine GO:0034097 9.26 IL6 IL6R IL6ST TIMP2
22 hepatic immune response GO:0002384 9.16 IL6 IL6R
23 interleukin-6-mediated signaling pathway GO:0070102 8.8 IL6 IL6R IL6ST

Molecular functions related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 CXCL8 IL6 INHA INHBA
2 growth factor activity GO:0008083 9.61 IL6 INHA INHBA
3 hormone activity GO:0005179 9.58 INHA INHBA RLN1
4 inhibin binding GO:0034711 9.32 INHA INHBA
5 ciliary neurotrophic factor receptor activity GO:0004897 9.26 IL6R IL6ST
6 interleukin-6 binding GO:0019981 9.16 IL6R IL6ST
7 interleukin-6 receptor activity GO:0004915 8.96 IL6R IL6ST
8 interleukin-6 receptor binding GO:0005138 8.8 IL6 IL6R IL6ST

Sources for Preterm Premature Rupture of the Membranes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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