MCID: PRT082
MIFTS: 51

Preterm Premature Rupture of the Membranes

Categories: Genetic diseases

Aliases & Classifications for Preterm Premature Rupture of the Membranes

MalaCards integrated aliases for Preterm Premature Rupture of the Membranes:

Name: Preterm Premature Rupture of the Membranes 53
Preterm Premature Rupture of the Membranes, Susceptibility to 53 13
Preterm Premature Rupture of Membranes 28 69
Pprom 53

Characteristics:

HPO:

31
preterm premature rupture of the membranes:
Inheritance polygenic inheritance


Classifications:



External Ids:

OMIM 53 610504
MedGen 39 C0729264
SNOMED-CT via HPO 65 237266003 44223004
UMLS 69 C0729264

Summaries for Preterm Premature Rupture of the Membranes

OMIM : 53 Preterm premature rupture of the membranes is defined as rupture of membranes before 37 weeks of gestation, which occurs in approximately 3% of all pregnancies and accounts for about one-third of spontaneous preterm births (ACOG Practice Bulletin, 1998). Srinivas and Macones (2005) reviewed the pathophysiology of PPROM and noted that familial clustering and ethnic differences in the incidence of PPROM suggest possible genetic influences. (610504)

MalaCards based summary : Preterm Premature Rupture of the Membranes, also known as preterm premature rupture of the membranes, susceptibility to, is related to chorioamnionitis and vaginitis, and has symptoms including premature rupture of membranes An important gene associated with Preterm Premature Rupture of the Membranes is SERPINH1 (Serpin Family H Member 1), and among its related pathways/superpathways are Pathways in cancer and Degradation of the extracellular matrix. The drugs Ampicillin and Cefuroxime have been mentioned in the context of this disorder. Affiliated tissues include testes, cervix and placenta, and related phenotypes are homeostasis/metabolism and neoplasm

Related Diseases for Preterm Premature Rupture of the Membranes

Diseases related to Preterm Premature Rupture of the Membranes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 chorioamnionitis 30.7 CXCL8 IL6 MMP8
2 vaginitis 30.2 CXCL8 IL6 SERPINH1
3 tendinopathy 10.4 MMP1 MMP8
4 recurrent corneal erosion 10.4 CXCL8 IL6
5 bagassosis 10.4 CXCL8 IL6
6 acute transverse myelitis 10.4 CXCL8 IL6
7 streptococcal toxic-shock syndrome 10.4 CXCL8 IL6
8 periodontitis, aggressive, 1 10.4 MMP1 MMP8
9 denture stomatitis 10.4 CXCL8 IL6
10 papillary conjunctivitis 10.4 CXCL8 IL6
11 squamous cell carcinoma of the hypopharynx 10.4 MMP1 TIMP2
12 acute monoblastic leukemia 10.4 CXCL8 IL6
13 gastroschisis 10.4 IL6 MMP8
14 chronic ulcer of skin 10.4 MMP1 MMP8
15 conjunctivochalasis 10.4 MMP1 TIMP2
16 capillary leak syndrome 10.4 CXCL8 IL6
17 adenomyosis 10.4 MMP1 TIMP2
18 periapical granuloma 10.3 CXCL8 MMP8
19 meconium aspiration syndrome 10.3 CXCL8 IL6
20 castleman disease 10.3 IL6 IL6R
21 lipodermatosclerosis 10.3 MMP1 TIMP2
22 louse-borne relapsing fever 10.3 CXCL8 IL6
23 transverse myelitis 10.3 CXCL8 IL6
24 cervical incompetence 10.3 IL6 SERPINH1
25 necrotizing fasciitis 10.3 CXCL8 IL6
26 periodontitis, chronic 10.3 IL6 MMP1 MMP8
27 cervicitis 10.3
28 gingival disease 10.3 IL6 MMP1 MMP8
29 fibromatosis, gingival, 1 10.3 MMP1 SERPINH1
30 opisthorchiasis 10.2 CXCL8 IL6R
31 cowpox 10.2 CXCL8 IL6
32 inguinal hernia 10.2 IL6 MMP1 TIMP2
33 cecal disease 10.2 IL6 PGRMC1
34 appendicitis 10.2 CXCL8 IL6 MMP8
35 aggressive periodontitis 10.2 CXCL8 IL6 MMP8
36 pulpitis 10.2 CXCL8 IL6 MMP1
37 bronchiolitis obliterans 10.2 CXCL8 IL6 MMP8
38 pulmonary disease, chronic obstructive 10.2 CXCL8 IL6 MMP1
39 bacterial meningitis 10.2 CXCL8 IL6 MMP8
40 gingivitis 10.2 CXCL8 IL6 MMP8
41 pulmonary emphysema 10.2 MMP1 MMP8 TIMP2
42 viral meningitis 10.2 CXCL8 IL6 TIMP2
43 bone inflammation disease 10.2 CXCL8 IL6 MMP1
44 bacteriuria 10.2 CXCL8 IL6
45 oligohydramnios 10.2
46 synovitis 10.2 CXCL8 IL6 MMP1
47 encephalomalacia 10.2 IL6 SERPINH1
48 osteoarthritis 10.1 CXCL8 IL6 MMP1
49 nodular malignant melanoma 10.1 MMP1 TIMP2
50 intrauterine infections 10.1

Graphical network of the top 20 diseases related to Preterm Premature Rupture of the Membranes:



Diseases related to Preterm Premature Rupture of the Membranes

Symptoms & Phenotypes for Preterm Premature Rupture of the Membranes

Clinical features from OMIM:

610504

Human phenotypes related to Preterm Premature Rupture of the Membranes:

31
# Description HPO Frequency HPO Source Accession
1 premature rupture of membranes 31 HP:0001788

MGI Mouse Phenotypes related to Preterm Premature Rupture of the Membranes:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 IL6 IL6R IL6ST INHA INHBA MMP1
2 neoplasm MP:0002006 9.1 IL6 IL6R IL6ST INHA MMP1 MMP8

Drugs & Therapeutics for Preterm Premature Rupture of the Membranes

Drugs for Preterm Premature Rupture of the Membranes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ampicillin Approved, Vet_approved Phase 4,Phase 3 69-53-4 6249
2
Cefuroxime Approved Phase 4 55268-75-2 5479529 5361202
3 Anti-Bacterial Agents Phase 4,Phase 3
4 Antibiotics, Antitubercular Phase 4,Phase 3
5 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
6 Antitubercular Agents Phase 4,Phase 3
7 cefuroxime axetil Phase 4
8
Cefazolin Approved Phase 3 25953-19-9 33255 656510
9
Clarithromycin Approved Phase 3 81103-11-9 84029
10
Erythromycin Approved, Investigational, Vet_approved Phase 3 114-07-8 12560
11
Azithromycin Approved Phase 3 83905-01-5 53477736 447043 55185
12
Betamethasone Approved, Vet_approved Phase 2, Phase 3 378-44-9 9782
13
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613 2171
14
Vitamin C Approved, Nutraceutical Phase 3,Phase 2 50-81-7 54670067 5785
15 Tocopherol Approved, Investigational, Nutraceutical Phase 3
16
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
17 Cytochrome P-450 CYP3A Inhibitors Phase 3
18 Cytochrome P-450 Enzyme Inhibitors Phase 3
19 Gastrointestinal Agents Phase 3
20 Antioxidants Phase 3,Phase 1,Phase 2
21 Micronutrients Phase 3,Phase 2,Early Phase 1
22 Protective Agents Phase 3,Phase 1,Phase 2,Early Phase 1
23 Trace Elements Phase 3,Phase 2,Early Phase 1
24 Vitamins Phase 3,Phase 2,Early Phase 1
25 Anti-Inflammatory Agents Phase 2, Phase 3
26 Erythromycin Estolate Phase 3
27 Erythromycin Ethylsuccinate Phase 3
28 Erythromycin stearate Phase 3
29 Tocopherols Phase 3
30 Tocotrienols Phase 3
31 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
32 Respiratory System Agents Phase 2, Phase 3,Phase 1
33 Anti-Asthmatic Agents Phase 2, Phase 3
34 Betamethasone benzoate Phase 2, Phase 3
35 Betamethasone sodium phosphate Phase 2, Phase 3
36 Betamethasone Valerate Phase 2, Phase 3 2152-44-5
37 Betamethasone-17,21-dipropionate Phase 2, Phase 3
38 glucocorticoids Phase 2, Phase 3
39 Hormone Antagonists Phase 2, Phase 3
40 Hormones Phase 2, Phase 3
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
42 Tocotrienol Investigational, Nutraceutical Phase 3 6829-55-6
43 Omega 3 Fatty Acid Nutraceutical Phase 3
44
Indomethacin Approved, Investigational Phase 2 53-86-1 3715
45
Acetaminophen Approved Phase 1, Phase 2 103-90-2 1983
46
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
47 Analgesics Phase 2
48 Analgesics, Non-Narcotic Phase 2
49 Anti-Inflammatory Agents, Non-Steroidal Phase 2
50 Antirheumatic Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 56)

# Name Status NCT ID Phase Drugs
1 Comparison of Two Antibiotic Prophylactic Protocols in Preterm Premature Rupture of the Membranes Recruiting NCT02819570 Phase 4 I.V cefuroxime 750 mg*3/d for 2 days;I.V ampicillin 2 gram x4/d for 2 days;P.O cefuroxime 500 mgx2/d for 5 days;P.O roxithromycin 150 mg*2/d for 7 days;P.O moxypen 500 mgx3/d for 5 days
2 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
3 Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane Unknown status NCT01503606 Phase 3 Cefazolin;Clarithromycin;Cefazolin;Clarithromycin
4 Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery Unknown status NCT01152528 Phase 3
5 Antibiotics Study in Preterm Premature Rupture of the Membranes Completed NCT01401179 Phase 3 cefazolin, erythromycin, clarithromycin
6 Does Vitamins C and E Supplementation of After Preterm Rupture of Membranes Prolong the Duration of Latency? A Prospective Randomized Controlled Study Completed NCT01266928 Phase 3 vitamine C and E
7 Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Recruiting NCT02939742 Phase 2, Phase 3 Betamethasone;Placebo
8 Treatment of ppROM With Erythromycin vs. Azithromycin Trial Recruiting NCT03060473 Phase 3 Azithromycin;Erythromycin;Ampicillin;Amoxicillin
9 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Recruiting NCT02336243 Phase 3
10 Pessary in Singleton Gestations With Short Cervix Without Prior Preterm Birth Recruiting NCT02716909 Phase 3
11 Erythromycin Versus Azithromycin in Preterm Premature Rupture of Membranes Withdrawn NCT01556334 Phase 3 Azithromycin;Erythromycin
12 Indomethacin Versus Placebo in Women With Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT00466128 Phase 2 indomethacin
13 N-acetylcysteine in Intra-amniotic Infection/Inflammation Completed NCT00397735 Phase 1, Phase 2 N-acetylcysteine or placebo
14 L-Arginine and Antioxidant Vitamins During Pregnancy to Reduce Preeclampsia Terminated NCT00469846 Phase 2
15 Fetoscopic Meningomyelocele Repair Study Recruiting NCT02230072 Phase 1
16 Pomegranate to Reduce Maternal and Fetal Oxidative Stress and Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of the Membranes Unknown status NCT01584323
17 The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes Unknown status NCT02635451
18 A Comparison of Bed Rest Versus Moderate Activity in Preterm Premature Rupture of Membranes (PPROM) Unknown status NCT02327637
19 Pomegranate to Reduce Maternal and Fetal Oxidative Stress and to Improve Outcome in Pregnancies Complicated With Preterm Premature Rupture of Membranes Unknown status NCT02069587
20 The Use of Cranberries in Women With Preterm Premature Rupture of Membranes Unknown status NCT00247104 Cranberries - Vaccinium macrocarpon
21 Preterm Premature Rupture of Membranes, Outpatient Management vs Inpatient Management Unknown status NCT02548013
22 Myometrial Thickness as a Predictor for the Latency Interval in PPROM Unknown status NCT02380560
23 Evaluation of the Role of Plasma Procalcitonin in Prediction of Intra-amniotic Infection in Preterm Premature Rupture of Membrane Unknown status NCT02104791 procalcitonin
24 Development of Pharmacokinetics Model in Pregnancy Women and Fetus Unknown status NCT01916330
25 Cervical Ripening in Premature Rupture of Membranes Unknown status NCT02314728 Misoprostol;Oxytocin
26 Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study. Unknown status NCT02340624
27 Multi-resistant Enterobacteriaceae Colonisation in Less Than 32 Weeks Pregnant Women Admitted to the Hospital. Unknown status NCT02631226
28 PPROM Erythromycin Versus Azithromycin Completed NCT01431248
29 Preterm Premature Rupture of Membranes (PPROM): Bed Rest Versus Activity Trial Completed NCT01544387
30 Transperineal Ultrasonography and Premature Rupture of Membranes Completed NCT02386644
31 Monitoring of the Inflammatory Response of Patients With Premature Rupture of Membranes With Bedside Tests Completed NCT00940043
32 Fetal Thymus Involution as a Predictor of Adverse Neonatal Outcomes Completed NCT01975792
33 Repeat Antenatal Corticosteroids Completed NCT03133104
34 Biomarkers of Intra-amniotic Infection in Women With Preterm Premature Ruptured Amniotic Membranes Completed NCT00701350
35 The Biomarker Study Completed NCT01148654
36 Clinical, Biochemical, Histological and Biophysical Parameters in the Prediction of Cerebral Palsy in Patients With Preterm Labor and Premature Rupture of Membranes Completed NCT00342667
37 Intrauterine Cleaning After Placental Delivery at Cesarean Section: RCT Completed NCT02152735
38 Protein and Ultrasound Indicators of Preterm Birth Completed NCT01412931
39 FOLCROM Trial: Foley Catheter in Rupture of Membranes Completed NCT01973036 Oxytocin
40 PPROM Registry (Preterm Premature Rupture of Membranes) Recruiting NCT02997345
41 Early Detection of Chorioamnionitis in Preterm Premature Rupture of Membranes Recruiting NCT02901795
42 Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of Membranes Recruiting NCT02702297
43 mtDNA as Novel Biomarker for Intra-amniotic Infection Recruiting NCT03306719
44 Prom by AmnioQuick Duo+ Recruiting NCT03435965
45 Fetoscopic Repair of Isolated Fetal Spina Bifida Recruiting NCT03090633
46 CellulaR Injury and Preterm Birth Recruiting NCT02441335
47 Pancreatic Stone Protein (PSP) in Pregnant Women Recruiting NCT02247297
48 Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being Recruiting NCT02536352 Early Phase 1 Prenatal vitamin-mineral containing 3 mg fluoride
49 The Association Between the Transfer of Lactobacilli From the Gastrointestinal Tract to the Vagina and the Prevention / Eradication of Abnormal Vaginal Flora in High Risk Pregnancies Recruiting NCT02430246
50 Indomethacin PK and PD Therapy in Pregnancy Recruiting NCT02451228

Search NIH Clinical Center for Preterm Premature Rupture of the Membranes

Genetic Tests for Preterm Premature Rupture of the Membranes

Genetic tests related to Preterm Premature Rupture of the Membranes:

# Genetic test Affiliating Genes
1 Preterm Premature Rupture of Membranes 28 SERPINH1

Anatomical Context for Preterm Premature Rupture of the Membranes

MalaCards organs/tissues related to Preterm Premature Rupture of the Membranes:

38
Testes, Cervix, Placenta, Liver, Bone, Thymus, Colon

Publications for Preterm Premature Rupture of the Membranes

Articles related to Preterm Premature Rupture of the Membranes:

(show top 50) (show all 243)
# Title Authors Year
1
Annual Report of the Perinatology Committee, Japan Society of Obstetrics and Gynecology, 2016: Overall report on a comprehensive retrospective study of obstetric management of preterm labor and preterm premature rupture of the membranes. ( 29114962 )
2018
2
Genital tract GBS and rate of histologic chorioamnionitis in patients with preterm premature rupture of membrane. ( 28715920 )
2017
3
Maternal obesity is associated with chorioamnionitis and earlier indicated preterm delivery among expectantly managed women with preterm premature rupture of membranes. ( 28936902 )
2017
4
Chorioamnionitis following preterm premature rupture of membranes and fetal heart rate variability. ( 28945767 )
2017
5
No. 233-Antibiotic Therapy in Preterm Premature Rupture of the Membranes. ( 28859768 )
2017
6
Cord Prolapse After Preterm Premature Rupture of the Membranes. ( 29066017 )
2017
7
Association of histological chorioamnionitis and magnesium sulfate treatment in singleton and dichorionic twin pregnancies with preterm premature rupture of membranes: preliminary observations. ( 28873067 )
2017
8
Neonatal and maternal outcomes following midtrimester preterm premature rupture of the membranes: a retrospective cohort study. ( 26831896 )
2016
9
Preterm labor and preterm premature rupture of membranes have a different pattern in the involved compartments of acute histologoic chorioamnionitis and/or funisitis: Patho-physiologic implication related to different clinical manifestations. ( 27090052 )
2016
10
Contribution of Histologic Chorioamnionitis and Fetal Inflammatory Response Syndrome to Increased Risk of Brain Injury in Infants With Preterm Premature Rupture of Membranes. ( 27353694 )
2016
11
ADAMTS4 and Oxidative/Antioxidative Status in Preterm Premature Rupture of Membranes. ( 27182768 )
2016
12
Non-Invasive Prediction of Histologic Chorioamnionitis in Women with Preterm Premature Rupture of Membranes. ( 26847301 )
2016
13
Accuracy of several maternal seric markers for predicting histological chorioamnionitis after preterm premature rupture of membranes: a prospective and multicentric study. ( 27591714 )
2016
14
Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes. ( 26690900 )
2016
15
Soluble HLA-G concentrations in maternal blood and cervical vaginal fluid of pregnant women with preterm premature rupture of membranes. ( 27232355 )
2016
16
Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes. ( 26812854 )
2016
17
Diagnostic and Prognostic Value of Presepsin for Subclinical Chorioamnionitis in Pregnancies between 23-28 Week with Preterm Premature Rupture of the Membranes. ( 27994922 )
2016
18
Pilot Randomized Controlled Trial to Evaluate the Impact of Bed Rest on Maternal and Fetal Outcomes in Women with Preterm Premature Rupture of the Membranes. ( 26461925 )
2015
19
Epigenetic regulation of lncRNA connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. ( 25884766 )
2015
20
Perinatal outcomes of pregnancies complicated by preterm premature rupture of the membranes before 34 weeks of gestation in a tertiary center in China: A retrospective review. ( 25787907 )
2015
21
Procalcitonin for prediction of chorioamnionitis in preterm premature rupture of membranes. ( 26333937 )
2015
22
[A case-control study on association between OAS1 polymorphism and susceptibility to spontaneous preterm birth and preterm premature rupture of membranes]. ( 26412166 )
2015
23
Related factors and adverse neonatal outcomes in women with preterm premature rupture of membranes complicated by histologic chorioamnionitis. ( 25644559 )
2015
24
Inflammatory predictors of neurologic disability after preterm premature rupture of membranes. ( 25223243 )
2015
25
Predictive factors for latency period in viable pregnancies complicated by preterm premature rupture of the membranes. ( 28913037 )
2015
26
Herpes Simplex Virus Cervicitis Mimicking Preterm Premature Rupture of Membranes. ( 25923023 )
2015
27
Aging of intrauterine tissues in spontaneous preterm birth and preterm premature rupture of the membranes: A systematic review of the literature. ( 26004735 )
2015
28
Short-Term and Long-Term Postnatal Outcomes of Expectant Management After Previable Preterm Premature Rupture of Membranes With and Without Persistent Oligohydramnios. ( 26444125 )
2015
29
Retention of cervical cerclage after preterm premature rupture of the membranes: a critical appraisal. ( 25416200 )
2015
30
Reply-Vaginal Sampling of Amniotic Fluid in Preterm Premature Rupture of Membranes: A New Technique for Early Detection of Subclinical Chorioamnionitis? ( 25108603 )
2014
31
Value of maternal procalcitonin levels for predicting subclinical intra-amniotic infection in preterm premature rupture of membranes. ( 24320627 )
2014
32
Absence of circadian rhythms of preterm premature rupture of membranes and preterm placental abruption. ( 25453346 )
2014
33
The influence of prolonged preterm premature rupture of the membranes on neonatal outcome of the presenting and non-presenting twin. ( 25124707 )
2014
34
Lipopolysaccharide-binding protein as marker of fetal inflammatory response syndrome after preterm premature rupture of membranes. ( 24335151 )
2014
35
Perinatal outcomes in pregnancies with oligohydramnios after preterm premature rupture of membranes. ( 25283853 )
2014
36
Progesterone receptor membrane component 1 (PGRMC1) expression in fetal membranes among women with preterm premature rupture of the membranes (PPROM). ( 24680695 )
2014
37
Usefulness of maternal serum C-reactive protein with vaginal Ureaplasma urealyticum as a marker for prediction of imminent preterm delivery and chorioamnionitis in patients with preterm labor or preterm premature rupture of membranes. ( 25503859 )
2014
38
The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes. ( 23536574 )
2013
39
Absorbable gelatin plug does not prevent iatrogenic preterm premature rupture of membranes after fetoscopic laser surgery for twin-twin transfusion syndrome. ( 23606579 )
2013
40
Early planned birth may reduce neonatal sepsis compared to expectant management following preterm premature rupture of the membranes close to term. ( 23125240 )
2013
41
Acute histologic chorioamnionitis is a risk factor for adverse neonatal outcome in late preterm birth after preterm premature rupture of membranes. ( 24324586 )
2013
42
The impact of tobacco use on preterm premature rupture of the membranes. ( 22930157 )
2013
43
Fetal tyhmus size as a predictor of histological chorioamnionitis in preterm premature rupture of membranes. ( 24089697 )
2013
44
Proadrenomedullin and serum amyloid A as a predictor of subclinical chorioamnionitis in preterm premature rupture of membranes. ( 24010826 )
2013
45
Prolidase, matrix metalloproteinases 1 and 13 activity, oxidative-antioxidative status as a marker of preterm premature rupture of membranes and chorioamnionitis in maternal vaginal washing fluids. ( 23983595 )
2013
46
Evaluation of vaginal fluid I^-human chorionic gonadotrophin for the diagnosis of preterm premature rupture of membranes. ( 23510392 )
2013
47
uPAR, IL-33, and ST2 Values as a Predictor of Subclinical Chorioamnionitis in Preterm Premature Rupture of Membranes. ( 24304137 )
2013
48
I+1-antitrypsin insufficiency is a possible contributor to preterm premature rupture of membranes. ( 21843112 )
2012
49
Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics. ( 22046977 )
2012
50
Maternal plasma prolidase, matrix metalloproteinases 1 and 13, and oxidative stress levels in pregnancies complicated by preterm premature rupture of the membranes and chorioamnionitis. ( 24592033 )
2012

Variations for Preterm Premature Rupture of the Membranes

ClinVar genetic disease variations for Preterm Premature Rupture of the Membranes:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SERPINH1 SERPINH1, -656C-T single nucleotide variant Pathogenic
2 MMP8 MMP8, HAPLOTYPE, TGG single nucleotide variant Pathogenic
3 MMP1 NM_002421.3(MMP1): c.-1673G= single nucleotide variant Pathogenic,risk factor GRCh37 Chromosome 11, 102670496: 102670496

Expression for Preterm Premature Rupture of the Membranes

Search GEO for disease gene expression data for Preterm Premature Rupture of the Membranes.

Pathways for Preterm Premature Rupture of the Membranes

Pathways related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1 12.63 CXCL8 IL6 IL6R IL6ST MMP1
2
Show member pathways
12.57 MMP1 MMP8 SERPINH1 TIMP2
3
Show member pathways
12.18 IL6 IL6R IL6ST
4 12.02 IL6 IL6R MMP1
5 12.01 CXCL8 IL6 IL6R
6
Show member pathways
11.95 IL6 IL6R IL6ST
7
Show member pathways
11.89 CXCL8 IL6 IL6R IL6ST MMP1
8
Show member pathways
11.75 MMP1 MMP8 TIMP2
9
Show member pathways
11.7 IL6 IL6R IL6ST
10 11.69 CXCL8 IL6 MMP1
11 11.68 IL6 IL6R IL6ST
12 11.68 CXCL8 IL6 IL6R MMP1
13
Show member pathways
11.66 IL6 IL6R IL6ST
14 11.63 CXCL8 IL6 MMP1
15
Show member pathways
11.53 CXCL8 IL6 IL6R IL6ST
16
Show member pathways
11.5 CXCL8 IL6 MMP1
17 11.46 CXCL8 MMP1 TIMP2
18
Show member pathways
11.42 IL6 IL6R IL6ST
19 11.31 IL6 IL6R INHBA
20
Show member pathways
11.23 IL6 IL6R IL6ST
21 11.11 CXCL8 IL6 MMP1
22 11.06 IL6 IL6R IL6ST
23 11.05 CXCL8 IL6 IL6R IL6ST INHBA
24 10.96 CXCL8 IL6 IL6R MMP1
25 10.87 IL6ST MMP1
26 10.86 CXCL8 IL6

GO Terms for Preterm Premature Rupture of the Membranes

Cellular components related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 CXCL8 IL6 INHA INHBA MMP8 SERPINH1
2 neuronal cell body GO:0043025 9.67 IL6ST INHA PGRMC1 TIMP2
3 extracellular region GO:0005576 9.65 CXCL8 IL6 IL6R IL6ST INHA INHBA
4 ciliary neurotrophic factor receptor complex GO:0070110 9.26 IL6R IL6ST
5 inhibin A complex GO:0043512 9.16 INHA INHBA
6 interleukin-6 receptor complex GO:0005896 8.8 IL6 IL6R IL6ST

Biological processes related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.89 CXCL8 IL6 INHBA TIMP2
2 cytokine-mediated signaling pathway GO:0019221 9.77 IL6 IL6R IL6ST
3 cell cycle arrest GO:0007050 9.74 CXCL8 INHA INHBA
4 extracellular matrix disassembly GO:0022617 9.71 MMP1 MMP8 TIMP2
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.69 IL6 IL6R IL6ST
6 response to cytokine GO:0034097 9.65 IL6R IL6ST TIMP2
7 regulation of receptor activity GO:0010469 9.65 CXCL8 IL6 INHA INHBA RLN1
8 positive regulation of osteoblast differentiation GO:0045669 9.63 IL6 IL6R IL6ST
9 endodermal cell differentiation GO:0035987 9.61 INHBA MMP8
10 endocrine pancreas development GO:0031018 9.61 IL6 IL6R
11 negative regulation of phosphorylation GO:0042326 9.58 INHA INHBA
12 positive regulation of chemokine production GO:0032722 9.58 IL6 IL6R
13 positive regulation of leukocyte chemotaxis GO:0002690 9.56 IL6 IL6R
14 positive regulation of acute inflammatory response GO:0002675 9.55 IL6 IL6ST
15 negative regulation of macrophage differentiation GO:0045650 9.52 INHA INHBA
16 positive regulation of follicle-stimulating hormone secretion GO:0046881 9.49 INHA INHBA
17 hemoglobin biosynthetic process GO:0042541 9.43 INHA INHBA
18 negative regulation of B cell differentiation GO:0045578 9.4 INHA INHBA
19 ciliary neurotrophic factor-mediated signaling pathway GO:0070120 9.37 IL6R IL6ST
20 negative regulation of interferon-gamma biosynthetic process GO:0045077 9.32 INHA INHBA
21 negative regulation of follicle-stimulating hormone secretion GO:0046882 9.16 INHA INHBA
22 hepatic immune response GO:0002384 8.96 IL6 IL6R
23 interleukin-6-mediated signaling pathway GO:0070102 8.8 IL6 IL6R IL6ST

Molecular functions related to Preterm Premature Rupture of the Membranes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.67 CXCL8 IL6 INHA INHBA
2 growth factor activity GO:0008083 9.61 IL6 INHA INHBA
3 hormone activity GO:0005179 9.58 INHA INHBA RLN1
4 inhibin binding GO:0034711 9.32 INHA INHBA
5 ciliary neurotrophic factor receptor activity GO:0004897 9.26 IL6R IL6ST
6 interleukin-6 binding GO:0019981 9.16 IL6R IL6ST
7 interleukin-6 receptor activity GO:0004915 8.96 IL6R IL6ST
8 interleukin-6 receptor binding GO:0005138 8.8 IL6 IL6R IL6ST

Sources for Preterm Premature Rupture of the Membranes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....