MCID: PRT082
MIFTS: 54

Preterm Premature Rupture of the Membranes malady

Genetic diseases (common) category

Summaries for Preterm Premature Rupture of the Membranes

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OMIM:47 Preterm premature rupture of the membranes is defined as rupture of membranes before 37 weeks of gestation, which... (610504) more...

MalaCards based summary: Preterm Premature Rupture of the Membranes, also known as preterm premature rupture of the membranes, susceptibility to, is related to chorioamnionitis and cervicitis, and has symptoms including premature rupture of membranesand polygenic inheritance. An important gene associated with Preterm Premature Rupture of the Membranes is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Syndecan-1-mediated signaling events. The compounds clodronate and tocilizumab have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and colon, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Preterm Premature Rupture of the Membranes

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Preterm Premature Rupture of the Membranes, Aliases & Descriptions:

Name: Preterm Premature Rupture of the Membranes 47 62
 
Preterm Premature Rupture of the Membranes, Susceptibility to 11 24


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

OMIM47 610504

Related Diseases for Preterm Premature Rupture of the Membranes

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Diseases related to Preterm Premature Rupture of the Membranes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis31.0SERPINH1, MMP8, IL8, IL6, CRP
2cervicitis10.8
3oligohydramnios10.7
4intrauterine infections10.6
5vaginitis10.5
6pulmonary immaturity10.4
7meningioma, familial10.1INHA
8aortic aneurysm10.1CRP
9classic kaposi sarcoma10.1IL6
10bacteriuria10.1CRP
11bronchiolitis10.1IL8
12bronchitis10.0CRP
13oral submucous fibrosis10.0MMP1
14pulpitis10.0MMP1
15sex cord-gonadal stromal tumor10.0INHBA, INHA
16multicentric castleman’s disease10.0IL6, IL6R
17reactive arthritis10.0MMP8, CRP
18cervical incompetence10.0SERPINH1
19aggressive periodontitis10.0MMP1, MMP8
20bronchiolitis obliterans10.0MMP8, IL8
21adult-onset still's disease10.0IL6, CRP
22bronchiectasis10.0MMP8, IL8
23gingivitis10.0MMP8, MMP1
24tongue cancer10.0MMP9, MMP8
25myasthenic syndrome, slow-channel congenital10.0CRP, IL8
26vascular disease10.0IL6, IL8
27skin disease10.0IL6, MMP9
28funisitis10.0MMP8, SERPINH1
29arthritis10.0IL8, IL6
30eye disease10.0CRP, IL6
31juvenile rheumatoid arthritis10.0IL6, CRP
32conjunctivochalasis10.0MMP1, MMP9
33choriocarcinoma10.0INHA, IL6ST, IL6R
34plasmacytoma10.0IL6ST, IL6, IL6R
35cholesteatoma10.0MMP9, MMP8
36psoriatic arthritis10.0CRP, MMP1
37respiratory failure10.0CRP, IL6
38peritonitis10.0CRP, IL6, MMP8
39keratoconus10.0MMP8, MMP1
40acute respiratory distress syndrome10.0IL8, IL6
41coronary artery disease10.0MMP8, IL6, CRP
42esophageal cancer10.0INHBA, MMP1, IL6ST
43kawasaki disease10.0CRP, MMP9
44middle ear cholesteatoma10.0MMP9, MMP1
45bacterial meningitis10.0CRP, IL8, MMP8
46vernal keratoconjunctivitis10.0IL8, MMP9
47colitis10.0IL8, IL6, IL6R
48thrombocytosis10.0IL6, CRP
49pheochromocytoma10.0INHA, INHBA, IL6ST, IL6R
50periodontal disease10.0CRP, IL6, MMP1

Graphical network of the top 20 diseases related to Preterm Premature Rupture of the Membranes:



Diseases related to preterm premature rupture of the membranes

Symptoms for Preterm Premature Rupture of the Membranes

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Clinical features from OMIM:

610504

HPO human phenotypes related to Preterm Premature Rupture of the Membranes:

id Description Frequency HPO Source Accession
1 premature rupture of membranes HP:0001788
2 polygenic inheritance HP:0010982

Drugs & Therapeutics for Preterm Premature Rupture of the Membranes

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Drug clinical trials:

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Genetic Tests for Preterm Premature Rupture of the Membranes

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Genetic tests related to Preterm Premature Rupture of the Membranes:

id Genetic test Affiliating Genes
1 Preterm Premature Rupture of Membranes24

Anatomical Context for Preterm Premature Rupture of the Membranes

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MalaCards organs/tissues related to Preterm Premature Rupture of the Membranes:

33
Placenta, Testes, Colon, Cervix

Animal Models for Preterm Premature Rupture of the Membranes or affiliated genes

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MGI Mouse Phenotypes related to Preterm Premature Rupture of the Membranes:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0IL6, IL6ST, MMP1, MMP8, MMP9, INHA
2MP:00053817.8INHA, INHBA, IL6, IL6ST, MMP9, SERPINH1
3MP:00053857.8IL6ST, MMP9, CRP, SERPINH1, INHA, IL6
4MP:00107717.6IL6, IL6ST, RLN1, INHBA, MMP9
5MP:00053797.5INHBA, IL6, IL6ST, IL6R, INHA, RLN1
6MP:00053907.2IL6, IL6ST, RLN1, MMP9, SERPINH1, INHBA
7MP:00053977.2IL6R, IL6, IL8, IL6ST, INHBA, INHA
8MP:00053877.2MMP1, MMP8, IL6, MMP9, IL6R, CRP
9MP:00053786.8INHA, IL6R, IL6, IL6ST, MMP9, SERPINH1
10MP:00107686.6MMP9, INHA, INHBA, RLN1, IL6ST, IL6R
11MP:00053766.4IL6R, CRP, IL6ST, INHBA, MMP1, MMP9

Publications for Preterm Premature Rupture of the Membranes

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Articles related to Preterm Premature Rupture of the Membranes:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Perinatal outcomes of pregnancies complicated by preterm premature rupture of the membranes before 34 weeks of gestation in a tertiary center in China: A retrospective review. (25787907)
2015
2
Retention of cervical cerclage after preterm premature rupture of the membranes: a critical appraisal. (25416200)
2015
3
The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes. (23536574)
2013
4
The impact of tobacco use on preterm premature rupture of the membranes. (22930157)
2013
5
Early planned birth may reduce neonatal sepsis compared to expectant management following preterm premature rupture of the membranes close to term. (23125240)
2013
6
Optimum mode of delivery in gestations complicated by preterm premature rupture of the membranes. (21854136)
2012
7
Maternal plasma prolidase, matrix metalloproteinases 1 and 13, and oxidative stress levels in pregnancies complicated by preterm premature rupture of the membranes and chorioamnionitis. (24592033)
2012
8
Antibiotics after preterm premature rupture of the membranes. (21508705)
2011
9
Correlation of myometrial thickness and the latency interval of women with preterm premature rupture of the membranes. (21298281)
2011
10
Amniotic fluid concentrations of soluble scavenger receptor for hemoglobin (sCD163) in pregnancy complicated by preterm premature rupture of the membranes and histologic chorioamnionitis. (21158489)
2011
11
Precipitated egg white as a sealant for iatrogenic preterm premature rupture of the membranes. (19942207)
2010
12
Influence of oligohydramnios on preterm premature rupture of the membranes at 30 to 36 weeks' gestation. (21176313)
2010
13
Neonatal outcomes after elective delivery management of preterm premature rupture of the membranes before 34 weeks' gestation (DOMINOS study). (19167805)
2009
14
Preterm premature rupture of the membranes and genital mycoplasmas. (20073423)
2009
15
The management of preterm premature rupture of the membranes near the limit of fetal viability. (19733274)
2009
16
Outcomes following prolonged preterm premature rupture of the membranes. (17660215)
2008
17
Amniocentesis in the management of preterm premature rupture of the membranes: a retrospective cohort analysis. (18609359)
2008
18
Modeling the duration of the latency period after preterm premature rupture of the membranes according to maternal and pregnancy characteristics: DOMINOS study. (18378062)
2008
19
Infection and the role of inflammation in preterm premature rupture of the membranes. (17448730)
2007
20
Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and preterm premature rupture of the membranes and subsequent cesarean delivery. (16260207)
2005
21
Preterm premature rupture of the membranes: diagnosis and management. (15519427)
2004
22
Outcomes after expectant management of extremely preterm premature rupture of the membranes. (14749657)
2004
23
Fetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathways. (15493713)
2004
24
Serum homocysteine levels after preterm premature rupture of the membranes. (15343233)
2004
25
Preterm premature rupture of the membranes is associated with a reduction in neonatal respiratory distress syndrome. (12193910)
2002
26
Fetal plasma MMP-9 concentrations are elevated in preterm premature rupture of the membranes. (12439489)
2002
27
Antenatal corticosteroids in women with preterm premature rupture of the membranes. (11817190)
2001
28
Persistent detection of alfa-fetoprotein in the vagina without overt preterm premature rupture of the membranes. Clinical and chemical characterizations. (11509846)
2001
29
Blood flow velocity waveforms from fetal peripheral pulmonary arteries in pregnancies with preterm premature rupture of the membranes: relationship with pulmonary hypoplasia. (10775989)
2000
30
Amniotic fluid index values after preterm premature rupture of the membranes and subsequent perinatal infection. (10942458)
2000
31
Effectiveness of antenatal corticosteroid administration after preterm premature rupture of the membranes. (11035339)
2000
32
Neonatal outcome following early onset preterm premature rupture of the membranes--a case controlled study. (10770110)
1999
33
Role of amniocentesis for the diagnosis of subclinical intra-amniotic infection in preterm premature rupture of the membranes. (10674829)
1999
34
Interleukin-6 concentrations in cervical secretions in the prediction of intrauterine infection in preterm premature rupture of the membranes. (9701687)
1998
35
Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. (9307346)
1997
36
Antibiotic therapy for preterm premature rupture of the membranes. (8912997)
1996
37
Antibiotic prophylaxis for presumptive group B streptococcal infection in preterm premature rupture of the membranes: effect on neonatal and maternal infectious morbidity. (18476117)
1996
38
Pregnancy outcome following preterm premature rupture of the membranes at less than 26 weeks' gestation. (1520195)
1992
39
Erythromycin therapy in preterm premature rupture of the membranes: a prospective, randomized trial of 220 patients. (1550145)
1992
40
Pregnancy outcome of preterm premature rupture of the membranes before 28 weeks. (1295650)
1992
41
The relationships among umbilical artery velocimetry, fetal biophysical profile, and placental inflammation in preterm premature rupture of the membranes. (1986622)
1991
42
Prolongation of the latency period in preterm premature rupture of the membranes using prophylactic antibiotics and tocolysis. (2213264)
1990
43
Symptoms that precede preterm labor and preterm premature rupture of the membranes. (2137968)
1990
44
Fetal behavior in preterm premature rupture of the membranes. (2673615)
1989
45
Does prolonged preterm premature rupture of the membranes predispose to abruptio placentae? (2668817)
1989
46
Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes. (3421266)
1988
47
The role of cervical cerclage in the management of preterm premature rupture of the membranes. (3337156)
1988
48
Is C-reactive protein really useful in preterm premature rupture of the membranes? (3426987)
1987
49
Preterm premature rupture of the membranes. (3815932)
1986
50
Amniocentesis for gram stain and culture in preterm premature rupture of the membranes. (2410839)
1985

Variations for Preterm Premature Rupture of the Membranes

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Clinvar genetic disease variations for Preterm Premature Rupture of the Membranes:

7
id Gene Variation Type Significance SNP ID Assembly Location
1MMP8MMP8, HAPLOTYPE, TGGsingle nucleotide variantPathogenic
2MMP1NM_002421.3(MMP1): c.-1673G=insertionPathogenic, risk factorrs1799750GRCh37Chr 11, 102670496: 102670496
3SERPINH1SERPINH1, -656C-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Preterm Premature Rupture of the Membranes

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Search GEO for disease gene expression data for Preterm Premature Rupture of the Membranes.

Pathways for genes affiliated with Preterm Premature Rupture of the Membranes

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Pathways related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MMP1, MMP9
29.7MMP9, MMP1
39.7IL6ST, MMP1
49.6IL6, IL8
59.6IL6, IL8
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.5IL6ST, CRP
7
Show member pathways
9.4MMP8, MMP1, MMP9
89.3MMP1, IL6, IL8
99.3IL6, IL8, MMP1
109.3IL6, IL8, MMP1
119.3IL6R, IL8, IL6
12
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.2IL6ST, IL6R, IL6
139.2IL6R, IL6, IL6ST
14
Show member pathways
9.2IL6ST, IL6R, IL6
15
Show member pathways
Type III interferon signaling38
9.2IL6R, IL6, IL6ST
16
Show member pathways
9.2IL6, IL6R, IL6ST
179.2IL6, IL6ST, IL6R
18
Show member pathways
9.2IL6, IL6R, IL6ST
19
Show member pathways
9.2IL6, IL6ST, IL6R
20
Show member pathways
Signaling Pathways in Glioblastoma38
9.2MMP9, IL8, MMP1
21
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1IL8, IL6, MMP9
229.1MMP9, IL6, IL8
239.1MMP9, IL8, IL6
249.1MMP9, IL8, IL6
25
Show member pathways
9.1SERPINH1, MMP9, MMP8, MMP1
26
Show member pathways
9.0MMP8, MMP1, IL6, MMP9
278.9IL6, MMP9, MMP1, IL6R
28
Show member pathways
8.9MMP8, MMP1, MMP9, IL8
29
Show member pathways
8.9MMP1, MMP8, MMP9, IL8
308.8IL6R, IL6ST, IL6, CRP
318.8IL6, MMP1, IL8, MMP9
328.8IL6, MMP9, MMP1, IL8
33
Show member pathways
8.8IL6, IL6R, IL6ST, IL8
34
Show member pathways
8.6INHA, INHBA, MMP1, IL8
35
Show member pathways
8.0IL6R, IL6, IL8, IL6ST, INHBA
368.0IL8, INHBA, IL6R, IL6, IL6ST

Compounds for genes affiliated with Preterm Premature Rupture of the Membranes

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Compounds related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1clodronate45 51 1311.8IL6, MMP8, MMP1
2tocilizumab45 1310.8CRP, IL6, IL6R
3pamidronate45 51 1311.7IL6, CRP, MMP1
4(4-aminophenyl)mercuric acetate459.7MMP9, MMP8, MMP1
5u0126459.7IL6, IL8, MMP1
6gm 6001619.7MMP8, MMP9, MMP1
7gi 254023x619.7MMP1, MMP9, MMP8
8uk 383367619.6MMP1, MMP8, MMP9
9cilomilast459.6IL8, MMP1, MMP9
10marimastat45 61 1311.5MMP9, MMP8, MMP1
11hydroxamate459.5MMP9, MMP8, IL6R, MMP1
12etanercept45 51 1311.4CRP, MMP1, IL8, IL6
13zoledronic acid459.3IL6, MMP1, MMP9
14neopterin459.3IL6, CRP, IL8, IL6R
15fluvastatin45 51 30 1312.3MMP9, MMP1, IL6, CRP
16pioglitazone30 45 51 1312.3CRP, IL6, MMP1, MMP9
17pdtc459.2IL8, IL6, MMP9, MMP1
18aprotinin45 1310.2MMP1, IL6, IL8, MMP9
19atorvastatin45 51 30 26 1313.2IL6, CRP, MMP9, MMP1
20rosiglitazone30 45 51 26 1313.2MMP9, CRP, IL6, MMP1
21gabexate mesilate459.2IL6, IL8, MMP9, CRP
22sp 60012545 6110.2IL6, MMP9, IL8, MMP1
238-isoprostane459.1MMP9, IL6, CRP, IL8
24ciglitazone45 3010.1MMP9, IL8, IL6
25troglitazone45 30 61 1312.1MMP1, IL6, MMP9, IL8
26herbimycin a45 6110.0MMP1, IL8, IL6, MMP9
27hyaluronic acid45 2610.0IL6, IL8, MMP1, MMP9
28prednisolone45 30 1311.0MMP1, IL6ST, IL6, CRP, IL6R
29methotrexate51 45 1310.9IL6R, IL6, MMP1, CRP, MMP9
30simvastatin45 51 61 30 26 1313.9MMP9, IL8, IL6, CRP
31fibrinogen458.9CRP, IL6, IL6R, MMP8, MMP9
32rantes458.9MMP9, IL6, IL6R, IL8, MMP1
33ribonucleic acid458.9IL6ST, MMP1, MMP9, INHA, IL6R
34n acetylcysteine458.8IL8, IL6, MMP9, CRP, MMP1
35sb 20358045 619.8MMP9, MMP1, IL8, CRP, IL6
36curcumin458.7MMP9, MMP1, IL8, IL6
37lactate458.5IL8, IL6, MMP9, MMP8, CRP, MMP1
38genistein45 30 61 3 26 1313.4MMP1, IL6ST, IL8, IL6, MMP8, MMP9
39cyclosporin a45 30 6110.4MMP8, MMP9, MMP1, IL8, IL6, IL6R
40dexamethasone45 51 30 1311.3IL6R, MMP9, MMP1, IL8, IL6ST, IL6
41alanine458.3MMP8, IL6, IL6ST, INHA, MMP9, CRP
42progesterone45 30 61 26 1312.3MMP8, IL6ST, MMP1, IL6R, INHA, INHBA
43creatinine458.2MMP1, MMP9, CRP, IL6R, IL6
44retinoic acid45 269.1IL6R, IL6, IL6ST, MMP1, MMP8, MMP9
45pge2458.1IL6, IL8, IL6ST, MMP1, MMP8, MMP9
46oligonucleotide458.0MMP1, IL6R, INHBA, INHA, MMP8, SERPINH1
47testosterone45 61 26 1310.8MMP1, MMP9, CRP, IL6R, IL6, INHBA
48estrogen457.7MMP1, IL6, INHBA, MMP9, IL6ST, INHA
49vegf457.4CRP, SERPINH1, MMP9, MMP8, MMP1, IL6ST
50cycloheximide457.2INHBA, MMP9, MMP1, IL6ST, IL6, IL6R

GO Terms for genes affiliated with Preterm Premature Rupture of the Membranes

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Cellular components related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.4MMP1, MMP8, MMP9
2interleukin-6 receptor complexGO:00058969.1IL6ST, IL6, IL6R
3inhibin A complexGO:00435129.0INHBA, INHA
4extracellular spaceGO:00056157.3SERPINH1, MMP9, MMP8, IL6ST, IL8, IL6
5extracellular regionGO:00055765.6CRP, INHA, INHBA, MMP9, MMP8, MMP1

Biological processes related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:000238410.2IL6R, IL6
2negative regulation of collagen biosynthetic processGO:003296610.1IL6, IL6R
3neutrophil mediated immunityGO:000244610.1IL6, IL6R
4positive regulation of leukocyte chemotaxisGO:000269010.1IL6R, IL6
5positive regulation of chemokine productionGO:003272210.0IL6R, IL6
6negative regulation of lipid storageGO:001088810.0CRP, IL6
7monocyte chemotaxisGO:000254810.0IL6R, IL6
8ciliary neurotrophic factor-mediated signaling pathwayGO:007012010.0IL6ST, IL6R
9defense response to Gram-negative bacteriumGO:005082910.0IL6, IL6R
10positive regulation of acute inflammatory responseGO:00026759.9IL6, IL6ST
11positive regulation of interleukin-6 productionGO:00327559.9IL6, IL6R
12endocrine pancreas developmentGO:00310189.8IL6, IL6R
13defense response to Gram-positive bacteriumGO:00508309.8CRP, IL6R, IL6
14acute-phase responseGO:00069539.8IL6, IL6R, CRP
15collagen catabolic processGO:00305749.7MMP9, MMP8, MMP1
16negative regulation of follicle-stimulating hormone secretionGO:00468829.7INHA, INHBA
17positive regulation of follicle-stimulating hormone secretionGO:00468819.7INHA, INHBA
18negative regulation of B cell differentiationGO:00455789.7INHA, INHBA
19negative regulation of interferon-gamma biosynthetic processGO:00450779.7INHA, INHBA
20hemoglobin biosynthetic processGO:00425419.7INHA, INHBA
21extracellular matrix disassemblyGO:00226179.7MMP1, MMP8, MMP9
22negative regulation of macrophage differentiationGO:00456509.7INHA, INHBA
23interleukin-6-mediated signaling pathwayGO:00701029.6IL6R, IL6, IL6ST
24positive regulation of tyrosine phosphorylation of Stat3 proteinGO:00425179.6IL6ST, IL6, IL6R
25positive regulation of osteoblast differentiationGO:00456699.6IL6R, IL6, IL6ST
26proteolysisGO:00065089.6MMP1, MMP8, MMP9
27negative regulation of phosphorylationGO:00423269.6INHA, INHBA
28extrinsic apoptotic signaling pathwayGO:00971919.5INHBA, IL6R
29erythrocyte differentiationGO:00302189.5INHBA, INHA
30extracellular matrix organizationGO:00301989.5MMP1, MMP8, MMP9, SERPINH1
31positive regulation of smooth muscle cell proliferationGO:00486619.5IL6R, IL6
32cytokine-mediated signaling pathwayGO:00192219.4IL6R, IL6, IL6ST
33ovarian follicle developmentGO:00015419.3INHBA, INHA
34inflammatory responseGO:00069549.2CRP, IL6, IL8
35negative regulation of cell cycleGO:00457869.2INHA, INHBA
36cell cycle arrestGO:00070509.2INHA, INHBA, IL8

Molecular functions related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1interleukin-6 bindingGO:00199819.8IL6ST, IL6R
2interleukin-6 receptor activityGO:00049159.8IL6ST, IL6R
3ciliary neurotrophic factor receptor activityGO:00048979.7IL6R, IL6ST
4interleukin-6 receptor bindingGO:00051389.4IL6R, IL6, IL6ST
5metalloendopeptidase activityGO:00042229.4MMP9, MMP8, MMP1
6growth factor activityGO:00080838.9IL6, INHBA, INHA
7hormone activityGO:00051798.8RLN1, INHBA, INHA
8cytokine activityGO:00051258.7INHA, INHBA, IL6
9protein bindingGO:00055156.7INHBA, MMP9, IL6ST, IL8, IL6, IL6R

Products for genes affiliated with Preterm Premature Rupture of the Membranes

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Sources for Preterm Premature Rupture of the Membranes

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet