MCID: PRT082
MIFTS: 38

Preterm Premature Rupture of the Membranes malady

Summaries for Preterm Premature Rupture of the Membranes

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46OMIM, 32MalaCards
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MalaCards: Preterm Premature Rupture of the Membranes is related to chorioamnionitis and cervicitis. An important gene associated with Preterm Premature Rupture of the Membranes is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are TGF-Beta Pathway and Elastic fibre formation. The compounds estrogen and endotoxin have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and tumorigenesis.

Description from OMIM:46 610504

Aliases & Classifications for Preterm Premature Rupture of the Membranes

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46OMIM
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Aliases & Descriptions:

preterm premature rupture of the membranes 46


Related Diseases for Preterm Premature Rupture of the Membranes

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17GeneCards, 18GeneDecks
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Diseases related to Preterm Premature Rupture of the Membranes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.9IL1R1, IL8, IL6, MMP8, SERPINH1
2cervicitis10.7
3oligohydramnios10.7
4vaginitis10.5
5pulmonary immaturity10.4
6ulcerative colitis10.0NOD2
7spondylitis10.0NOD2
8crohn's disease10.0NOD2
9pyoderma gangrenosum10.0NOD2
10hypertension10.0CALCA
11familial mediterranean fever10.0NOD2
12pouchitis10.0NOD2
13dermatitis10.0NOD2
14otitis media10.0CD14
15polycystic ovary syndrome10.0INHA
16periventricular leukomalacia10.0SERPINH1
17alpha 1-antitrypsin deficiency10.0SERPINA1
18migraine10.0CALCA
19gingival overgrowth10.0MMP1
20conjunctivochalasis10.0MMP1
21bronchitis10.0SERPINA1
22paget's disease of bone10.0CALCA
23cerebral palsy10.0MMP8
24pulpitis10.0MMP1
25hypercholesterolemia10.0CD14
26osteomyelitis10.0BMP2
27bronchiolitis10.0IL8
28encephalomyelitis10.0FASLG
29alopecia areata10.0IL1R1
30ovarian hyperstimulation syndrome10.0IL6R
31diarrhea10.0CALCA
32rhinitis10.0IL8
33fibromyalgia10.0SERPINA1
34funisitis10.0MMP8, SERPINH1
35mastitis10.0IL8
36acquired immunodeficiency syndrome10.0IL6
37gingivitis10.0MMP1, MMP8
38eye disease10.0IL6
39radiculopathy10.0BMP2
40cervical cancer10.0IL1R1
41primary hyperoxaluria10.0IL6
42nephritis10.0IL1R1
43renal osteodystrophy10.0CALCA
44complex regional pain syndrome10.0CALCA
45hyperhomocysteinemia10.0ELN
46duodenal ulcer10.0IL8
47endometrial carcinoma10.0INHBA, INHA
48bronchopulmonary dysplasia10.0IL8
49sarcoidosis10.0NOD2, CD14
50neuropathy10.0CALCA

Graphical network of the top 20 diseases related to Preterm Premature Rupture of the Membranes:



Diseases related to preterm premature rupture of the membranes

Clinical Features for Preterm Premature Rupture of the Membranes

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46OMIM
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Clinical features from OMIM:

610504

Drugs & Therapeutics for Preterm Premature Rupture of the Membranes

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Preterm Premature Rupture of the Membranes

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Anatomical Context for Preterm Premature Rupture of the Membranes

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Animal Models for Preterm Premature Rupture of the Membranes or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Preterm Premature Rupture of the Membranes:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.6FASLG, IL1R1, IL6, PTX3, SERPINH1, ELN
2MP:00020069.6CALCA, FASLG, INHA, IL1R1, IL6, MMP8
3MP:00053709.3IL6ST, IL6R, IL6, IL1R1, INHA, FASLG
4MP:00053859.3CALCA, FASLG, BMP2, INHA, IL1R1, IL6ST
5MP:00053769.2RLN1, CALCA, CD14, INHBA, IL1R1, IL6ST
6MP:00053909.2SERPINH1, RLN1, FASLG, BMP2, CD14, INHA
7MP:00053819.1LOXL1, FASLG, BMP2, INHA, INHBA, IL6
8MP:00053899.1RLN1, LOXL1, FASLG, BMP2, INHA, PTX3
9MP:00107719.1RLN1, LOXL1, CALCA, FASLG, IL1R1, IL6
10MP:00053798.8RLN1, FASLG, INHA, INHBA, IL1R1, IL6
11MP:00053878.6FASLG, CD14, INHA, IL1R1, IL8, IL6
12MP:00053788.6RLN1, BMP2, CD14, INHA, INHBA, IL1R1
13MP:00107688.4CD14, BMP2, FASLG, CALCA, RLN1, INHA

Publications for Preterm Premature Rupture of the Membranes

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Genetic Variations for Preterm Premature Rupture of the Membranes

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Expression for genes affiliated with Preterm Premature Rupture of the Membranes

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Preterm Premature Rupture of the Membranes

Search GEO for disease gene expression data for Preterm Premature Rupture of the Membranes.

Pathways for genes affiliated with Preterm Premature Rupture of the Membranes

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51QIAGEN, 53Reactome, 29KEGG, 55SinoBiological, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1IL6R, BMP2
2
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10.0ELN, BMP2, LOXL1
310.0IL8, IL1R1, CD14
49.9INHBA, INHA, BMP2
5
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.9IL6, FASLG, CALCA
69.9CD14, IL8, IL6
79.9CD14, IL8, IL6
89.9CD14, IL8, IL6
99.9IL6, IL8, CD14
10
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9.9IL8, IL6, NOD2
119.9IL8, IL6, MMP1
129.9MMP1, IL6, IL8
139.9IL8, IL6, MMP1
14
Mucin expression in CF via IL-6, IL-17 signaling pathways
9.8IL6, IL6R, IL6ST
159.8IL6, IL6R, IL6ST
16
Immune response IL-6 signaling pathway
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9.8IL6ST, IL6R, IL6
17
Cell adhesion ECM remodeling
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9.8IL8, MMP8, MMP1, ELN
189.8IL6R, IL6, IL1R1, CD14
19
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9.8LOXL1, BMP2, MMP8, MMP1, SERPINH1
20
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9.8IL6, IL8, IL1R1, CD14
219.8CD14, IL1R1, IL8, IL6
229.7MMP1, IL6, IL8, BMP2
23
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9.7IL6, IL8, CD14, FASLG
24
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.7MMP1, IL6ST, IL6R, IL6
259.7FASLG, IL8, IL6, ELN
26
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9.7IL6ST, IL6R, IL6, IL1R1
27
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9.6CD14, IL1R1, IL8, IL6, NOD2
289.6IL6ST, IL8, INHBA, BMP2
29
Immune response Bacterial infections in normal airways
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9.6FASLG, CD14, IL1R1, IL8, IL6
30
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9.5NOD2, IL6ST, IL6R, IL6, IL1R1
31
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9.5IL1R1, IL6, IL6R, IL6ST, NOD2
32
Cytokine production by Th17 cells in CF (Mouse model)
9.5CD14, IL8, IL6, IL6R, IL6ST
33
Hide members
9.3FASLG, BMP2, CD14, INHBA, IL6R, IL6ST

Compounds for genes affiliated with Preterm Premature Rupture of the Membranes

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44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7ELN
2endotoxin4410.6FASLG
3cycloheximide4410.5ELN, FASLG
4hydrocortisone44 2 59 1113.2MMP1, ELN, CALCA, IL8
5indomethacin44 59 28 1113.2IL1R1, ELN, BMP2, CALCA
6clodronate44 49 1112.2MMP1, MMP8, IL6, CALCA
7alendronate44 49 1112.1CALCA, BMP2, MMP8, MMP1
8zoledronic acid4410.1IL6, BMP2, CALCA, MMP1
9rantes4410.0FASLG, IL1R1, CD14, IL6, IL6R
10lipoteichoic acid4410.0IL8, IL6, IL1R1, CD14
11peptidoglycan44 2811.0IL1R1, NOD2, IL8, CD14, IL6
12il 104410.0IL1R1, IL8, IL6, IL6R, NOD2
13neopterin449.9IL6, IL6R, IL8, IL1R1, CD14
14etanercept44 49 1111.9IL6, IL8, MMP1, IL1R1
15muramyl dipeptide44 2810.9IL8, NOD2, CD14
16pentoxifylline44 1110.9BMP2, IL1R1, IL6, MMP1, CD14, IL8
17cyclosporin a44 28 5911.7CALCA, SERPINH1, MMP1, MMP8, IL6R, IL1R1
18acth449.7SERPINA1, IL6, IL6ST, CALCA, INHA, IL1R1
19ascorbic acid44 2410.7SERPINA1, ELN, SERPINH1, MMP1, IL1R1, BMP2
20tgf beta1449.7MMP1, FASLG, ELN, BMP2, IL6
21ribonucleic acid449.7IL6ST, MMP1, IL6R, INHA, IL1R1, BMP2
22fibrinogen449.7ELN, MMP8, IL6R, SERPINA1, IL1R1, CD14
23prednisolone44 28 1111.7IL6, IL6R, IL6ST, MMP1, NOD2, IL1R1
24creatinine449.7IL6R, CD14, MMP1, BMP2, ELN, SERPINA1
25h2o2449.7MMP1, IL1R1, ELN, FASLG, MMP8
26paraffin449.6FASLG, CD14, INHA, IL1R1, SERPINA1, ELN
27hyaluronic acid44 2410.6IL6, MMP1, IL1R1, BMP2, FASLG, ELN
28n acetylcysteine449.6FASLG, IL1R1, IL8, IL6, ELN, MMP1
29sb 20358044 5910.6IL8, MMP1, BMP2, FASLG, IL6, IL1R1
30vitamin d449.6BMP2, CD14, IL6, IL1R1, ELN, IL6ST
31histamine44 28 2411.5CALCA, IL6R, IL6, RLN1, CD14, ELN
32infliximab44 49 1111.5NOD2, IL1R1, MMP1, IL6
33serine449.5IL1R1, NOD2, ELN, MMP1, MMP8, IL6ST
34actinomycin d449.4ELN, PTX3, IL8, IL1R1, BMP2, FASLG
35heparin44 28 11 2412.4IL1R1, BMP2, CD14, IL8, SERPINA1, ELN
36pd 98,059449.4MMP1, CD14, IL8, FASLG, IL6, BMP2
37genistein44 28 59 2 11 2414.4MMP8, FASLG, BMP2, IL8, ELN, MMP1
38dexamethasone44 49 28 1112.4CD14, PTX3, IL6ST, IL6R, IL6, IL1R1
39cysteine449.3SERPINA1, IL8, MMP8, MMP1, IL1R1, BMP2
40alanine449.3INHA, CD14, FASLG, ELN, IL6, MMP8
41lactate449.2FASLG, CALCA, ELN, MMP1, MMP8, IL6
42cholesterol44 28 11 2412.2IL1R1, BMP2, FASLG, PTX3, SERPINA1, IL6ST
43testosterone44 59 11 2412.1ELN, MMP1, IL6R, IL6, BMP2, FASLG
44progesterone44 59 28 11 2413.1MMP1, INHA, INHBA, MMP8, IL1R1, IL6ST
45retinoic acid44 2410.1IL6R, IL6ST, IL6, ELN, MMP1, MMP8
46oligonucleotide448.9INHBA, SERPINA1, SERPINH1, FASLG, IL1R1, BMP2
47nitric oxide44 11 2410.8MMP8, NOD2, PTX3, SERPINA1, SERPINH1, IL6
48tyrosine448.7IL1R1, IL6, IL6R, IL6ST, SERPINH1, INHA
49calcium44 49 11 2411.7MMP1, ELN, NOD2, MMP8, BMP2, IL6ST
50vegf448.7IL6ST, FASLG, BMP2, CD14, IL1R1, IL8

GO Terms for genes affiliated with Preterm Premature Rupture of the Membranes

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16Gene Ontology
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Cellular components related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inhibin A complexGO:04351210.0INHA, INHBA
2interleukin-6 receptor complexGO:0058969.8IL6ST, IL6R, IL6
3proteinaceous extracellular matrixGO:0055789.8ELN, SERPINA1, MMP1, MMP8
4cell surfaceGO:0099869.4BMP2, CD14, IL1R1, IL6R, NOD2
5extracellular spaceGO:0056158.5LOXL1, CALCA, FASLG, BMP2, CD14, IL8
6extracellular regionGO:0055767.3ELN, RLN1, LOXL1, CALCA, FASLG, BMP2

Biological processes related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:00238410.5IL6, IL6R
2negative regulation of collagen biosynthetic processGO:03296610.5IL6, IL6R
3positive regulation of B cell activationGO:05087110.4IL6, NOD2
4positive regulation of follicle-stimulating hormone secretionGO:04688110.4INHA, INHBA
5negative regulation of follicle-stimulating hormone secretionGO:04688210.4INHBA, INHA
6negative regulation of B cell differentiationGO:04557810.4INHA, INHBA
7negative regulation of interferon-gamma biosynthetic processGO:04507710.4INHA, INHBA
8hemoglobin biosynthetic processGO:04254110.3INHA, INHBA
9monocyte chemotaxisGO:00254810.3IL6R, IL6, CALCA
10response to heatGO:00940810.3CALCA, CD14, IL6
11ciliary neurotrophic factor-mediated signaling pathwayGO:07012010.3IL6ST, IL6R
12defense response to Gram-positive bacteriumGO:05083010.3IL6, IL6R, NOD2
13neutrophil mediated immunityGO:00244610.3IL6R, IL6
14positive regulation of interleukin-6 productionGO:03275510.3NOD2, IL6R, IL6
15negative regulation of cell cycleGO:04578610.3INHBA, INHA, BMP2
16acute-phase responseGO:00695310.3SERPINA1, IL6R, IL6
17interleukin-6-mediated signaling pathwayGO:07010210.2IL6, IL6R, IL6ST
18negative regulation of macrophage differentiationGO:04565010.2INHA, INHBA
19positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.2IL6ST, IL6R, IL6
20response to cytokine stimulusGO:03409710.2SERPINA1, IL6ST, IL6R
21cell surface receptor signaling pathwayGO:00716610.1CD14, INHA, INHBA, IL1R1
22response to lipopolysaccharideGO:03249610.1SERPINA1, NOD2, IL6, FASLG
23positive regulation of MAPK cascadeGO:04341010.1BMP2, IL6, IL6R
24positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.1NOD2, IL6R, IL6
25positive regulation of acute inflammatory responseGO:00267510.1IL6ST, IL6
26positive regulation of osteoblast differentiationGO:04566910.1BMP2, IL6, IL6R, IL6ST
27positive regulation of astrocyte differentiationGO:04871110.1IL6ST, BMP2
28positive regulation of leukocyte chemotaxisGO:00269010.0IL6, IL6R
29extracellular matrix organizationGO:03019810.0ELN, SERPINH1, MMP1, MMP8, BMP2, LOXL1
30cell-cell signalingGO:00726710.0CALCA, FASLG, BMP2, INHA, INHBA
31positive regulation of ERK1 and ERK2 cascadeGO:07037410.0NOD2, IL6, BMP2
32positive regulation of ossificationGO:0457789.9BMP2, CALCA
33inflammatory responseGO:0069549.8CALCA, BMP2, CD14, IL8, IL6, PTX3

Molecular functions related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1interleukin-6 bindingGO:01998110.2IL6R, IL6ST
2interleukin-6 receptor activityGO:00491510.1IL6R, IL6ST
3ciliary neurotrophic factor receptor activityGO:00489710.0IL6ST, IL6R
4interleukin-6 receptor bindingGO:00513810.0IL6ST, IL6R, IL6
5hormone activityGO:0051799.9RLN1, CALCA, INHA, INHBA
6receptor bindingGO:0051029.8INHA, BMP2, FASLG, CALCA
7cytokine activityGO:0051259.7FASLG, BMP2, INHA, INHBA, IL6
8growth factor activityGO:0080839.6BMP2, INHA, INHBA, IL6
9protein bindingGO:0055157.8CALCA, FASLG, BMP2, CD14, INHA, INHBA

Products for genes affiliated with Preterm Premature Rupture of the Membranes

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Sources for Preterm Premature Rupture of the Membranes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet