MCID: PRT082
MIFTS: 47

Preterm Premature Rupture of the Membranes malady

Summaries for Preterm Premature Rupture of the Membranes

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48OMIM, 34MalaCards
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MalaCards: Preterm Premature Rupture of the Membranes is related to chorioamnionitis and sepsis. An important gene associated with Preterm Premature Rupture of the Membranes is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are Immune response MIF mediated glucocorticoid regulation and Cytokine Network. The compounds emedastine and turpentine have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and colon, and related mouse phenotypes are tumorigenesis and cardiovascular system.

Description from OMIM:48 610504

Aliases & Classifications for Preterm Premature Rupture of the Membranes

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48OMIM
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Aliases & Descriptions:

preterm premature rupture of the membranes 48


Related Diseases for Preterm Premature Rupture of the Membranes

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18GeneCards, 19GeneDecks
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Diseases related to Preterm Premature Rupture of the Membranes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.8SERPINH1, MMP8, IL8, IL6, CRP
2sepsis30.5IL8, IL6, IL6R, CRP
3cervicitis10.7
4oligohydramnios10.7
5intrauterine infections10.6
6vaginitis10.5
7pulmonary immaturity10.4
8meningioma10.1INHA
9aortic aneurysm10.1CRP
10bacteriuria10.1CRP
11cervical incompetence10.1SERPINH1
12bronchitis10.1CRP
13bronchiolitis10.1IL8
14sex cord-gonadal stromal tumor10.1INHBA, INHA
15funisitis10.1MMP8, SERPINH1
16conjunctivochalasis10.1MMP9
17castleman's disease10.1IL6, IL6R
18reactive arthritis10.1CRP, MMP8
19crohn's disease10.1CRP
20bronchiolitis obliterans10.1IL8, MMP8
21keloids10.1SERPINH1, MMP8
22periodontal disease10.1IL6, CRP
23adult-onset still's disease10.1CRP, IL6
24bronchiectasis10.1IL8, MMP8
25eye disease10.0IL6, CRP
26juvenile rheumatoid arthritis10.0IL6, CRP
27tongue cancer10.0MMP8, MMP9
28slow-channel congenital myasthenic syndrome10.0IL8, CRP
29respiratory failure10.0CRP, IL6
30vascular disease10.0IL8, IL6
31arthritis10.0IL8, IL6
32pulmonary emphysema10.0MMP8, MMP9
33choriocarcinoma10.0IL6R, IL6ST, INHA
34bacterial vaginosis10.0IL8, SERPINH1
35thrombocytosis10.0IL6, CRP
36abdominal aortic aneurysm10.0MMP8, MMP9
37plasmacytoma10.0IL6R, IL6, IL6ST
38adult respiratory distress syndrome10.0IL8, IL6
39cholesteatoma10.0MMP9, MMP8
40peritonitis10.0CRP, IL6, MMP8
41skin disease10.0MMP9, IL6
42leukopenia10.0IL6, CRP
43newborn respiratory distress syndrome10.0IL8, IL6
44coronary artery disease10.0MMP8, IL6, CRP
45behcet's disease10.0CRP, IL8
46carotid stenosis10.0CRP, MMP9
47cerebrovascular disease10.0CRP, IL6ST, MMP8
48bacterial meningitis10.0CRP, IL8, MMP8
49kawasaki disease10.0CRP, MMP9
50pheochromocytoma10.0IL6R, IL6ST, INHBA, INHA

Graphical network of the top 20 diseases related to Preterm Premature Rupture of the Membranes:



Diseases related to preterm premature rupture of the membranes

Symptoms for Preterm Premature Rupture of the Membranes

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48OMIM
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Clinical features from OMIM:

610504

Drugs & Therapeutics for Preterm Premature Rupture of the Membranes

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Preterm Premature Rupture of the Membranes

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Anatomical Context for Preterm Premature Rupture of the Membranes

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34MalaCards
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MalaCards organs/tissues related to Preterm Premature Rupture of the Membranes:

34
Placenta, Testes, Colon, Cervix

Animal Models for Preterm Premature Rupture of the Membranes or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Preterm Premature Rupture of the Membranes:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3INHA, MMP9, MMP8, IL6ST, IL6, IL6R
2MP:00053857.9INHA, SERPINH1, MMP9, IL6ST, IL6, CRP
3MP:00053817.8INHA, INHBA, SERPINH1, MMP9, IL6ST, IL6
4MP:00053897.7IL6ST, RLN1, MMP9, INHBA, INHA
5MP:00053797.5INHA, INHBA, RLN1, IL6ST, IL6, IL6R
6MP:00053877.4INHA, MMP9, MMP8, IL6ST, IL8, IL6
7MP:00107717.3INHBA, MMP9, RLN1, IL6ST, IL6
8MP:00053907.3IL6, INHA, INHBA, SERPINH1, MMP9, RLN1
9MP:00053977.2INHA, INHBA, MMP9, IL6ST, IL8, IL6
10MP:00053786.9INHA, INHBA, SERPINH1, MMP9, RLN1, IL6ST
11MP:00053766.7INHA, INHBA, MMP9, RLN1, IL6ST, IL6
12MP:00107686.7INHA, INHBA, SERPINH1, MMP9, RLN1, IL6ST

Publications for Preterm Premature Rupture of the Membranes

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53PubMed
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Articles related to Preterm Premature Rupture of the Membranes:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes. (23536574)
2013
2
The impact of tobacco use on preterm premature rupture of the membranes. (22930157)
2013
3
Early planned birth may reduce neonatal sepsis compared to expectant management following preterm premature rupture of the membranes close to term. (23125240)
2013
4
Optimum mode of delivery in gestations complicated by preterm premature rupture of the membranes. (21854136)
2012
5
Antibiotics after preterm premature rupture of the membranes. (21508705)
2011
6
Correlation of myometrial thickness and the latency interval of women with preterm premature rupture of the membranes. (21298281)
2011
7
Amniotic fluid concentrations of soluble scavenger receptor for hemoglobin (sCD163) in pregnancy complicated by preterm premature rupture of the membranes and histologic chorioamnionitis. (21158489)
2011
8
Precipitated egg white as a sealant for iatrogenic preterm premature rupture of the membranes. (19942207)
2010
9
Influence of oligohydramnios on preterm premature rupture of the membranes at 30 to 36 weeks' gestation. (21176313)
2010
10
Neonatal outcomes after elective delivery management of preterm premature rupture of the membranes before 34 weeks' gestation (DOMINOS study). (19167805)
2009
11
Preterm premature rupture of the membranes and genital mycoplasmas. (20073423)
2009
12
The management of preterm premature rupture of the membranes near the limit of fetal viability. (19733274)
2009
13
Outcomes following prolonged preterm premature rupture of the membranes. (17660215)
2008
14
Amniocentesis in the management of preterm premature rupture of the membranes: a retrospective cohort analysis. (18609359)
2008
15
Modeling the duration of the latency period after preterm premature rupture of the membranes according to maternal and pregnancy characteristics: DOMINOS study. (18378062)
2008
16
Infection and the role of inflammation in preterm premature rupture of the membranes. (17448730)
2007
17
Transcervical intrapartum amnioinfusion for preterm premature rupture of the membranes. (16730113)
2007
18
Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and preterm premature rupture of the membranes and subsequent cesarean delivery. (16260207)
2005
19
Preterm premature rupture of the membranes: diagnosis and management. (15519427)
2004
20
Outcomes after expectant management of extremely preterm premature rupture of the membranes. (14749657)
2004
21
Fetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathways. (15493713)
2004
22
Serum homocysteine levels after preterm premature rupture of the membranes. (15343233)
2004
23
Preterm premature rupture of the membranes is associated with a reduction in neonatal respiratory distress syndrome. (12193910)
2002
24
Fetal plasma MMP-9 concentrations are elevated in preterm premature rupture of the membranes. (12439489)
2002
25
Cost-effectiveness of induction after preterm premature rupture of the membranes. (12439494)
2002
26
Antenatal corticosteroids in women with preterm premature rupture of the membranes. (11817190)
2001
27
Persistent detection of alfa-fetoprotein in the vagina without overt preterm premature rupture of the membranes. Clinical and chemical characterizations. (11509846)
2001
28
Blood flow velocity waveforms from fetal peripheral pulmonary arteries in pregnancies with preterm premature rupture of the membranes: relationship with pulmonary hypoplasia. (10775989)
2000
29
Amniotic fluid index values after preterm premature rupture of the membranes and subsequent perinatal infection. (10942458)
2000
30
Effectiveness of antenatal corticosteroid administration after preterm premature rupture of the membranes. (11035339)
2000
31
Neonatal outcome following early onset preterm premature rupture of the membranes--a case controlled study. (10770110)
1999
32
Role of amniocentesis for the diagnosis of subclinical intra-amniotic infection in preterm premature rupture of the membranes. (10674829)
1999
33
Interleukin-6 concentrations in cervical secretions in the prediction of intrauterine infection in preterm premature rupture of the membranes. (9701687)
1998
34
Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. (9307346)
1997
35
Antibiotic therapy for preterm premature rupture of the membranes. (8912997)
1996
36
Antibiotic prophylaxis for presumptive group B streptococcal infection in preterm premature rupture of the membranes: effect on neonatal and maternal infectious morbidity. (18476117)
1996
37
Diagnosis of preterm premature rupture of the membranes using a newly developed AFP monoclonal antibody test kit. (7538939)
1995
38
Pregnancy outcome following preterm premature rupture of the membranes at less than 26 weeks' gestation. (1520195)
1992
39
Erythromycin therapy in preterm premature rupture of the membranes: a prospective, randomized trial of 220 patients. (1550145)
1992
40
Pregnancy outcome of preterm premature rupture of the membranes before 28 weeks. (1295650)
1992
41
The relationships among umbilical artery velocimetry, fetal biophysical profile, and placental inflammation in preterm premature rupture of the membranes. (1986622)
1991
42
Prolongation of the latency period in preterm premature rupture of the membranes using prophylactic antibiotics and tocolysis. (2213264)
1990
43
Symptoms that precede preterm labor and preterm premature rupture of the membranes. (2137968)
1990
44
Fetal behavior in preterm premature rupture of the membranes. (2673615)
1989
45
Does prolonged preterm premature rupture of the membranes predispose to abruptio placentae? (2668817)
1989
46
Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes. (3421266)
1988
47
The role of cervical cerclage in the management of preterm premature rupture of the membranes. (3337156)
1988
48
Is C-reactive protein really useful in preterm premature rupture of the membranes? (3426987)
1987
49
Preterm premature rupture of the membranes. (3815932)
1986
50
Amniocentesis for gram stain and culture in preterm premature rupture of the membranes. (2410839)
1985

Variations for Preterm Premature Rupture of the Membranes

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Preterm Premature Rupture of the Membranes:

1
id Gene Name Type Significance SNP ID Assembly Location
1MMP8MMP8, HAPLOTYPE, TGGsingle nucleotide variantPathogenic/card/preterm_premature_rupture_of_the_membranes
2MMP1NM_002421.3(MMP1): c.-1673G=insertionPathogenic, risk factorrs1799750GRCh37Chr 11, 102670496: 102670496
3SERPINH1SERPINH1, -656C-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Preterm Premature Rupture of the Membranes

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Preterm Premature Rupture of the Membranes

Search GEO for disease gene expression data for Preterm Premature Rupture of the Membranes.

Pathways for genes affiliated with Preterm Premature Rupture of the Membranes

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51PathCards, 61Thomson Reuters, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database, 5Cell Signaling Technology, 56Reactome, 55R&D Systems, 13EMD Millipore
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Pathways related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL6, IL8
29.6IL6, IL8
39.6IL6, IL8
49.6IL6, IL8
59.6IL6, MMP9
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.5CRP, IL6ST
7
Show member pathways
9.4SERPINH1, MMP9, MMP8
89.3IL6R, IL6, IL8
99.2IL6R, IL6, MMP9
10
Show member pathways
Type III interferon signaling39
9.2IL6ST, IL6, IL6R
11
Show member pathways
9.2IL6ST, IL6, IL6R
12
Show member pathways
9.2IL6R, IL6, IL6ST
13
Show member pathways
9.2IL6R, IL6, IL6ST
14
Show member pathways
9.2IL6ST, IL6, IL6R
159.2IL6ST, IL6, IL6R
169.2IL6R, IL6, IL6ST
17
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.2IL6ST, IL6, IL6R
18
Show member pathways
9.2IL8, MMP8, MMP9
199.1MMP9, IL8, IL6
20
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.1MMP9, IL8, IL6
219.1MMP9, IL8, IL6
229.1MMP9, IL8, IL6
239.1IL6, IL8, MMP9
249.1IL6, IL8, MMP9
258.8IL6ST, IL6, IL6R, CRP
26
Show member pathways
8.8IL6ST, IL8, IL6, IL6R
278.0IL6R, IL6, IL8, IL6ST, INHBA
28
Show member pathways
8.0INHBA, IL6ST, IL8, IL6, IL6R

Compounds for genes affiliated with Preterm Premature Rupture of the Membranes

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46Novoseek, 12DrugBank, 52PharmGKB, 3BitterDB, 30IUPHAR, 62Tocris Bioscience, 25HMDB
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Compounds related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1emedastine46 1211.0IL8, IL6
2turpentine4610.0CRP, IL6
3tepoxalin4610.0IL6, IL8
4iron sucrose4610.0IL6, CRP
5sivelestat469.9IL6, IL8
6cdp571469.8CRP, IL6
7tocilizumab46 1210.8IL6R, CRP, IL6
8hydroxamate469.7MMP9, MMP8, IL6R
9il 10469.7IL8, IL6, IL6R
10rebamipide469.6IL8, IL6
11etanercept46 52 1211.6IL8, CRP, IL6
12rituximab46 52 1211.6IL6R, IL6, CRP
13ifn-alpha469.5IL6R, IL6, IL6ST
14parthenolide46 310.5MMP9, IL8, IL6
15fenofibrate46 52 1211.5IL6, MMP9, CRP
16ciglitazone46 3010.5IL8, MMP9, IL6
17ivig469.5IL6, MMP9, CRP
18fluvastatin46 52 30 1212.5MMP9, CRP, IL6
19ccl346 3010.4IL6, IL8, MMP9
20pioglitazone30 46 52 1212.4MMP9, IL6, CRP
21neopterin469.3IL6R, IL6, IL8, CRP
22pdtc469.3IL6, IL8, MMP9
23prednisolone46 30 1211.2IL6R, IL6, IL6ST, CRP
24methotrexate52 46 1211.2IL6, IL6R, CRP, MMP9
25aprotinin46 1210.2IL8, IL6, MMP9
26gabexate mesilate469.2IL6, CRP, IL8, MMP9
27rantes469.2IL6R, MMP9, IL8, IL6
288-isoprostane469.2MMP9, IL8, CRP, IL6
29ribonucleic acid469.1INHA, MMP9, IL6ST, IL6R
30simvastatin46 52 62 30 25 1214.1CRP, IL6, IL8, MMP9
31n acetylcysteine469.1IL8, IL6, CRP, MMP9
32sb 20358046 6210.1IL6, CRP, MMP9, IL8
33fibrinogen469.0MMP9, CRP, IL6R, IL6, MMP8
34gp 130468.9IL6R, IL6ST, IL6
35histamine46 30 2510.9IL6, IL8, IL6R, RLN1
36ly294002468.9CRP, IL6, MMP9, IL8
37lactate468.8MMP9, IL6, CRP, IL8, MMP8
38genistein46 30 62 3 25 1213.7MMP8, IL6ST, MMP9, IL8, IL6
39nitric oxide46 25 1210.7IL8, RLN1, SERPINH1, IL6, MMP8
40cyclosporin a46 30 6210.6IL8, MMP8, SERPINH1, IL6, MMP9, IL6R
41dexamethasone46 52 30 1211.6IL6ST, MMP9, IL8, IL6, IL6R
42progesterone46 30 62 25 1212.6IL6R, INHA, INHBA, MMP8, IL6ST
43alanine468.4IL6ST, MMP9, INHA, IL6, MMP8, CRP
44pge2468.4IL6ST, IL6, MMP8, IL6R, IL8, MMP9
45oligonucleotide468.3INHA, IL6R, IL6ST, INHBA, MMP8, SERPINH1
46testosterone46 62 25 1211.1INHA, INHBA, CRP, MMP9, IL6, IL6R
47tyrosine468.0IL6R, IL6, IL6ST, MMP9, SERPINH1, INHA
48estrogen467.9INHA, INHBA, IL6ST, IL6, MMP9
49vegf467.7CRP, SERPINH1, MMP9, MMP8, IL6ST, IL8
50cycloheximide467.5IL6, INHBA, MMP9, CRP, IL6R, IL6ST

GO Terms for genes affiliated with Preterm Premature Rupture of the Membranes

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17Gene Ontology
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Cellular components related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inhibin A complexGO:0435129.3INHBA, INHA
2interleukin-6 receptor complexGO:0058968.9IL6R, IL6, IL6ST
3extracellular spaceGO:0056157.2SERPINH1, MMP9, MMP8, IL6ST, IL8, IL6
4extracellular regionGO:0055765.8CRP, INHA, INHBA, MMP9, MMP8, RLN1

Biological processes related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:00238410.2IL6R, IL6
2negative regulation of collagen biosynthetic processGO:03296610.1IL6, IL6R
3neutrophil mediated immunityGO:00244610.1IL6, IL6R
4positive regulation of leukocyte chemotaxisGO:00269010.1IL6, IL6R
5positive regulation of chemokine productionGO:03272210.1IL6, IL6R
6monocyte chemotaxisGO:00254810.0IL6R, IL6
7negative regulation of lipid storageGO:01088810.0CRP, IL6
8defense response to Gram-negative bacteriumGO:05082910.0IL6, IL6R
9ciliary neurotrophic factor-mediated signaling pathwayGO:07012010.0IL6ST, IL6R
10positive regulation of interleukin-6 productionGO:03275510.0IL6, IL6R
11endocrine pancreas developmentGO:0310189.9IL6, IL6R
12positive regulation of acute inflammatory responseGO:0026759.9IL6, IL6ST
13positive regulation of smooth muscle cell proliferationGO:0486619.8IL6, IL6R
14defense response to Gram-positive bacteriumGO:0508309.8CRP, IL6R, IL6
15acute-phase responseGO:0069539.7IL6, IL6R, CRP
16negative regulation of follicle-stimulating hormone secretionGO:0468829.7INHA, INHBA
17positive regulation of follicle-stimulating hormone secretionGO:0468819.7INHA, INHBA
18negative regulation of B cell differentiationGO:0455789.7INHA, INHBA
19negative regulation of interferon-gamma biosynthetic processGO:0450779.7INHA, INHBA
20hemoglobin biosynthetic processGO:0425419.7INHA, INHBA
21negative regulation of macrophage differentiationGO:0456509.7INHBA, INHA
22interleukin-6-mediated signaling pathwayGO:0701029.6IL6R, IL6, IL6ST
23positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.6IL6ST, IL6, IL6R
24positive regulation of osteoblast differentiationGO:0456699.6IL6R, IL6, IL6ST
25negative regulation of phosphorylationGO:0423269.6INHBA, INHA
26response to cytokineGO:0340979.6IL6R, IL6ST
27erythrocyte differentiationGO:0302189.6INHBA, INHA
28extrinsic apoptotic signaling pathwayGO:0971919.5INHBA, IL6R
29cytokine-mediated signaling pathwayGO:0192219.5IL6R, IL6, IL6ST
30ovarian follicle developmentGO:0015419.5INHBA, INHA
31negative regulation of cell cycleGO:0457869.4INHA, INHBA
32inflammatory responseGO:0069549.3CRP, IL6, IL8
33positive regulation of T cell proliferationGO:0421029.3IL6, IL6ST
34extracellular matrix organizationGO:0301989.3MMP8, MMP9, SERPINH1
35cell cycle arrestGO:0070509.2IL8, INHBA, INHA

Molecular functions related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1interleukin-6 bindingGO:0199819.8IL6ST, IL6R
2interleukin-6 receptor activityGO:0049159.7IL6ST, IL6R
3ciliary neurotrophic factor receptor activityGO:0048979.7IL6R, IL6ST
4interleukin-6 receptor bindingGO:0051389.4IL6R, IL6, IL6ST
5growth factor activityGO:0080838.9INHA, INHBA, IL6
6hormone activityGO:0051798.7RLN1, INHBA, INHA
7cytokine activityGO:0051258.7IL6, INHBA, INHA
8protein bindingGO:0055156.7INHBA, MMP9, IL6ST, IL8, IL6, IL6R

Products for genes affiliated with Preterm Premature Rupture of the Membranes

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Sources for Preterm Premature Rupture of the Membranes

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet