MCID: PRT082
MIFTS: 33

Preterm Premature Rupture of the Membranes malady

Summaries for Preterm Premature Rupture of the Membranes

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47OMIM, 33MalaCards
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MalaCards: Preterm Premature Rupture of the Membranes is related to chorioamnionitis and sepsis. An important gene associated with Preterm Premature Rupture of the Membranes is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are TGF-Beta Pathway and Elastic fibre formation. The compounds estrogen and endotoxin have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and tumorigenesis.

Description from OMIM:47 610504

Aliases & Classifications for Preterm Premature Rupture of the Membranes

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47OMIM
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Aliases & Descriptions:

preterm premature rupture of the membranes 47


Related Diseases for Preterm Premature Rupture of the Membranes

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17GeneCards, 18GeneDecks
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Diseases related to Preterm Premature Rupture of the Membranes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.9IL1R1, IL8, IL6, MMP8, SERPINH1
2sepsis30.5CALCA, CD14, IL1R1, IL8, IL6, IL6R
3pulmonary immaturity10.4
4trachoma10.4
5n syndrome10.4
6hemoglobin so10.4
7ulcerative colitis10.0NOD2
8spondylitis10.0NOD2
9crohn's disease10.0NOD2
10pyoderma gangrenosum10.0NOD2
11hypertension10.0CALCA
12familial mediterranean fever10.0NOD2
13pouchitis10.0NOD2
14dermatitis10.0NOD2
15otitis media10.0CD14
16polycystic ovary syndrome10.0INHA
17periventricular leukomalacia10.0SERPINH1
18alpha 1-antitrypsin deficiency10.0SERPINA1
19migraine10.0CALCA
20gingival overgrowth10.0MMP1
21conjunctivochalasis10.0MMP1
22bronchitis10.0SERPINA1
23paget's disease of bone10.0CALCA
24cerebral palsy10.0MMP8
25pulpitis10.0MMP1
26hypercholesterolemia10.0CD14
27osteomyelitis10.0BMP2
28bronchiolitis10.0IL8
29encephalomyelitis10.0FASLG
30alopecia areata10.0IL1R1
31ovarian hyperstimulation syndrome10.0IL6R
32diarrhea10.0CALCA
33rhinitis10.0IL8
34fibromyalgia10.0SERPINA1
35funisitis10.0MMP8, SERPINH1
36mastitis10.0IL8
37acquired immunodeficiency syndrome10.0IL6
38gingivitis10.0MMP1, MMP8
39eye disease10.0IL6
40radiculopathy10.0BMP2
41cervical cancer10.0IL1R1
42primary hyperoxaluria10.0IL6
43nephritis10.0IL1R1
44renal osteodystrophy10.0CALCA
45complex regional pain syndrome10.0CALCA
46hyperhomocysteinemia10.0ELN
47duodenal ulcer10.0IL8
48endometrial carcinoma10.0INHBA, INHA
49bronchopulmonary dysplasia10.0IL8
50sarcoidosis10.0NOD2, CD14

Graphical network of the top 20 diseases related to Preterm Premature Rupture of the Membranes:



Diseases related to preterm premature rupture of the membranes

Clinical Features for Preterm Premature Rupture of the Membranes

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47OMIM
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Clinical features from OMIM:

610504

Drugs & Therapeutics for Preterm Premature Rupture of the Membranes

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Preterm Premature Rupture of the Membranes

Search CenterWatch for Preterm Premature Rupture of the Membranes

Genetic Tests for Preterm Premature Rupture of the Membranes

Anatomical Context for Preterm Premature Rupture of the Membranes

Animal Models for Preterm Premature Rupture of the Membranes or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Preterm Premature Rupture of the Membranes

Genetic Variations for Preterm Premature Rupture of the Membranes

Expression for genes affiliated with Preterm Premature Rupture of the Membranes

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Preterm Premature Rupture of the Membranes

Search GEO for disease gene expression data for Preterm Premature Rupture of the Membranes.

Pathways for genes affiliated with Preterm Premature Rupture of the Membranes

Sources:
52QIAGEN, 54Reactome, 30KEGG, 56SinoBiological, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems
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Pathways related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1IL6R, BMP2
2
Hide members
10.0ELN, BMP2, LOXL1
310.0IL8, IL1R1, CD14
49.9INHBA, INHA, BMP2
5
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.9IL6, FASLG, CALCA
69.9CD14, IL8, IL6
79.9CD14, IL8, IL6
89.9CD14, IL8, IL6
99.9IL6, IL8, CD14
10
Hide members
9.9IL8, IL6, NOD2
119.9IL8, IL6, MMP1
129.9MMP1, IL6, IL8
139.9IL8, IL6, MMP1
14
Mucin expression in CF via IL-6, IL-17 signaling pathways
9.8IL6, IL6R, IL6ST
159.8IL6, IL6R, IL6ST
16
Immune response IL-6 signaling pathway
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9.8IL6ST, IL6R, IL6
17
Cell adhesion ECM remodeling
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9.8IL8, MMP8, MMP1, ELN
189.8IL6R, IL6, IL1R1, CD14
19
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9.8LOXL1, BMP2, MMP8, MMP1, SERPINH1
20
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9.8IL6, IL8, IL1R1, CD14
219.8CD14, IL1R1, IL8, IL6
229.7MMP1, IL6, IL8, BMP2
23
Hide members
9.7IL6, IL8, CD14, FASLG
24
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.7MMP1, IL6ST, IL6R, IL6
259.7FASLG, IL8, IL6, ELN
26
Hide members
9.7IL6ST, IL6R, IL6, IL1R1
27
Hide members
9.6CD14, IL1R1, IL8, IL6, NOD2
289.6IL6ST, IL8, INHBA, BMP2
29
Immune response Bacterial infections in normal airways
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9.6FASLG, CD14, IL1R1, IL8, IL6
30
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9.5NOD2, IL6ST, IL6R, IL6, IL1R1
31
Hide members
9.5IL1R1, IL6, IL6R, IL6ST, NOD2
32
Cytokine production by Th17 cells in CF (Mouse model)
9.5CD14, IL8, IL6, IL6R, IL6ST
33
Hide members
9.3FASLG, BMP2, CD14, INHBA, IL6R, IL6ST

Compounds for genes affiliated with Preterm Premature Rupture of the Membranes

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
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Compounds related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7ELN
2endotoxin4510.6FASLG
3cycloheximide4510.5ELN, FASLG
4hydrocortisone45 2 60 1113.2MMP1, ELN, CALCA, IL8
5indomethacin45 60 29 1113.2IL1R1, ELN, BMP2, CALCA
6clodronate45 50 1112.2MMP1, MMP8, IL6, CALCA
7alendronate45 50 1112.1CALCA, BMP2, MMP8, MMP1
8zoledronic acid4510.1IL6, BMP2, CALCA, MMP1
9rantes4510.0FASLG, IL1R1, CD14, IL6, IL6R
10lipoteichoic acid4510.0IL8, IL6, IL1R1, CD14
11peptidoglycan45 2911.0IL1R1, NOD2, IL8, CD14, IL6
12il 104510.0IL1R1, IL8, IL6, IL6R, NOD2
13neopterin459.9IL6, IL6R, IL8, IL1R1, CD14
14etanercept45 50 1111.9IL6, IL8, MMP1, IL1R1
15muramyl dipeptide45 2910.9IL8, NOD2, CD14
16pentoxifylline45 1110.9BMP2, IL1R1, IL6, MMP1, CD14, IL8
17cyclosporin a45 29 6011.7CALCA, SERPINH1, MMP1, MMP8, IL6R, IL1R1
18acth459.7SERPINA1, IL6, IL6ST, CALCA, INHA, IL1R1
19ascorbic acid45 2410.7SERPINA1, ELN, SERPINH1, MMP1, IL1R1, BMP2
20tgf beta1459.7MMP1, FASLG, ELN, BMP2, IL6
21ribonucleic acid459.7IL6ST, MMP1, IL6R, INHA, IL1R1, BMP2
22fibrinogen459.7ELN, MMP8, IL6R, SERPINA1, IL1R1, CD14
23prednisolone45 29 1111.7IL6, IL6R, IL6ST, MMP1, NOD2, IL1R1
24creatinine459.7IL6R, CD14, MMP1, BMP2, ELN, SERPINA1
25h2o2459.7MMP1, IL1R1, ELN, FASLG, MMP8
26paraffin459.6FASLG, CD14, INHA, IL1R1, SERPINA1, ELN
27hyaluronic acid45 2410.6IL6, MMP1, IL1R1, BMP2, FASLG, ELN
28n acetylcysteine459.6FASLG, IL1R1, IL8, IL6, ELN, MMP1
29sb 20358045 6010.6IL8, MMP1, BMP2, FASLG, IL6, IL1R1
30vitamin d459.6BMP2, CD14, IL6, IL1R1, ELN, IL6ST
31histamine45 29 2411.5CALCA, IL6R, IL6, RLN1, CD14, ELN
32infliximab45 50 1111.5NOD2, IL1R1, MMP1, IL6
33serine459.5IL1R1, NOD2, ELN, MMP1, MMP8, IL6ST
34actinomycin d459.4ELN, PTX3, IL8, IL1R1, BMP2, FASLG
35heparin45 29 11 2412.4IL1R1, BMP2, CD14, IL8, SERPINA1, ELN
36pd 98,059459.4MMP1, CD14, IL8, FASLG, IL6, BMP2
37genistein45 29 60 2 11 2414.4MMP8, FASLG, BMP2, IL8, ELN, MMP1
38dexamethasone45 50 29 1112.4CD14, PTX3, IL6ST, IL6R, IL6, IL1R1
39cysteine459.3SERPINA1, IL8, MMP8, MMP1, IL1R1, BMP2
40alanine459.3INHA, CD14, FASLG, ELN, IL6, MMP8
41lactate459.2FASLG, CALCA, ELN, MMP1, MMP8, IL6
42cholesterol45 29 11 2412.2IL1R1, BMP2, FASLG, PTX3, SERPINA1, IL6ST
43testosterone45 60 11 2412.1ELN, MMP1, IL6R, IL6, BMP2, FASLG
44progesterone45 60 29 11 2413.1MMP1, INHA, INHBA, MMP8, IL1R1, IL6ST
45retinoic acid45 2410.1IL6R, IL6ST, IL6, ELN, MMP1, MMP8
46oligonucleotide458.9INHBA, SERPINA1, SERPINH1, FASLG, IL1R1, BMP2
47nitric oxide45 11 2410.8MMP8, NOD2, PTX3, SERPINA1, SERPINH1, IL6
48tyrosine458.7IL1R1, IL6, IL6R, IL6ST, SERPINH1, INHA
49calcium45 50 11 2411.7MMP1, ELN, NOD2, MMP8, BMP2, IL6ST
50vegf458.7IL6ST, FASLG, BMP2, CD14, IL1R1, IL8

GO Terms for genes affiliated with Preterm Premature Rupture of the Membranes

Sources:
16Gene Ontology
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Cellular components related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inhibin A complexGO:04351210.0INHA, INHBA
2interleukin-6 receptor complexGO:0058969.8IL6, IL6R, IL6ST
3proteinaceous extracellular matrixGO:0055789.8MMP8, MMP1, SERPINA1, ELN
4cell surfaceGO:0099869.4BMP2, CD14, IL1R1, IL6R, NOD2
5extracellular spaceGO:0056158.5IL6, IL8, CD14, BMP2, FASLG, CALCA
6extracellular regionGO:0055767.3ELN, RLN1, LOXL1, CALCA, FASLG, BMP2

Biological processes related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:00238410.5IL6, IL6R
2negative regulation of collagen biosynthetic processGO:03296610.5IL6, IL6R
3positive regulation of B cell activationGO:05087110.4IL6, NOD2
4positive regulation of follicle-stimulating hormone secretionGO:04688110.4INHA, INHBA
5negative regulation of follicle-stimulating hormone secretionGO:04688210.4INHBA, INHA
6negative regulation of B cell differentiationGO:04557810.4INHA, INHBA
7negative regulation of interferon-gamma biosynthetic processGO:04507710.4INHA, INHBA
8hemoglobin biosynthetic processGO:04254110.3INHA, INHBA
9monocyte chemotaxisGO:00254810.3IL6R, IL6, CALCA
10response to heatGO:00940810.3CALCA, CD14, IL6
11ciliary neurotrophic factor-mediated signaling pathwayGO:07012010.3IL6ST, IL6R
12defense response to Gram-positive bacteriumGO:05083010.3IL6, IL6R, NOD2
13neutrophil mediated immunityGO:00244610.3IL6R, IL6
14positive regulation of interleukin-6 productionGO:03275510.3NOD2, IL6R, IL6
15negative regulation of cell cycleGO:04578610.3INHBA, INHA, BMP2
16acute-phase responseGO:00695310.3SERPINA1, IL6R, IL6
17interleukin-6-mediated signaling pathwayGO:07010210.2IL6, IL6R, IL6ST
18negative regulation of macrophage differentiationGO:04565010.2INHA, INHBA
19positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.2IL6ST, IL6R, IL6
20response to cytokine stimulusGO:03409710.2SERPINA1, IL6ST, IL6R
21cell surface receptor signaling pathwayGO:00716610.1CD14, INHA, INHBA, IL1R1
22response to lipopolysaccharideGO:03249610.1SERPINA1, NOD2, IL6, FASLG
23positive regulation of MAPK cascadeGO:04341010.1BMP2, IL6, IL6R
24positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.1NOD2, IL6R, IL6
25positive regulation of acute inflammatory responseGO:00267510.1IL6ST, IL6
26positive regulation of osteoblast differentiationGO:04566910.1BMP2, IL6, IL6R, IL6ST
27positive regulation of astrocyte differentiationGO:04871110.1IL6ST, BMP2
28positive regulation of leukocyte chemotaxisGO:00269010.0IL6, IL6R
29extracellular matrix organizationGO:03019810.0ELN, SERPINH1, MMP1, MMP8, BMP2, LOXL1
30cell-cell signalingGO:00726710.0CALCA, FASLG, BMP2, INHA, INHBA
31positive regulation of ERK1 and ERK2 cascadeGO:07037410.0NOD2, IL6, BMP2
32positive regulation of ossificationGO:0457789.9BMP2, CALCA
33inflammatory responseGO:0069549.8CALCA, BMP2, CD14, IL8, IL6, PTX3

Molecular functions related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1interleukin-6 bindingGO:01998110.2IL6R, IL6ST
2interleukin-6 receptor activityGO:00491510.1IL6R, IL6ST
3ciliary neurotrophic factor receptor activityGO:00489710.0IL6ST, IL6R
4interleukin-6 receptor bindingGO:00513810.0IL6ST, IL6R, IL6
5hormone activityGO:0051799.9RLN1, CALCA, INHA, INHBA
6receptor bindingGO:0051029.8INHA, BMP2, FASLG, CALCA
7cytokine activityGO:0051259.7FASLG, BMP2, INHA, INHBA, IL6
8growth factor activityGO:0080839.6BMP2, INHA, INHBA, IL6
9protein bindingGO:0055157.8CALCA, FASLG, BMP2, CD14, INHA, INHBA

Products for genes affiliated with Preterm Premature Rupture of the Membranes

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Sources for Preterm Premature Rupture of the Membranes

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet