MCID: PRT082
MIFTS: 48

Preterm Premature Rupture of the Membranes malady

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Summaries for Preterm Premature Rupture of the Membranes

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MalaCards based summary: Preterm Premature Rupture of the Membranes is related to chorioamnionitis and sepsis, and has symptoms including An important gene associated with Preterm Premature Rupture of the Membranes is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are Syndecan-1-mediated signaling events and Cell adhesion Cell matrix glycoconjugates. The compounds clodronate and tocilizumab have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and colon, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Description from OMIM:46 610504

Aliases & Classifications for Preterm Premature Rupture of the Membranes

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Preterm Premature Rupture of the Membranes, Aliases & Descriptions:

Name: Preterm Premature Rupture of the Membranes 46 62


Related Diseases for Preterm Premature Rupture of the Membranes

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Diseases related to Preterm Premature Rupture of the Membranes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1chorioamnionitis30.5MMP8, CRP, IL6, SERPINH1, IL8
2sepsis30.5IL6, IL6R, CRP, IL8
3cervicitis10.7
4oligohydramnios10.7
5intrauterine infections10.6
6vaginitis10.5
7meningioma10.5INHA
8aortic aneurysm10.5CRP
9kaposi's sarcoma10.5IL6
10bacteriuria10.5CRP
11bronchiolitis10.4IL8
12bronchitis10.4CRP
13oral submucous fibrosis10.4MMP1
14pulpitis10.4MMP1
15abdominal aortic aneurysm10.4MMP9
16pulmonary immaturity10.4
17sex cord-gonadal stromal tumor10.4INHBA, INHA
18castleman's disease10.3IL6R, IL6
19reactive arthritis10.3CRP, MMP8
20cervical incompetence10.3SERPINH1
21aggressive periodontitis10.3MMP8, MMP1
22bronchiolitis obliterans10.3MMP8, IL8
23adult-onset still's disease10.3IL6, CRP
24gingivitis10.3MMP1, MMP8
25bronchiectasis10.3IL8, MMP8
26tongue cancer10.3MMP8, MMP9
27slow-channel congenital myasthenic syndrome10.2IL8, CRP
28vascular disease10.2IL6, IL8
29skin disease10.2IL6, MMP9
30funisitis10.2MMP8, SERPINH1
31arthritis10.2IL6, IL8
32spiradenoma10.2IL6, CRP
33juvenile rheumatoid arthritis10.2CRP, IL6
34conjunctivochalasis10.2MMP1, MMP9
35cholesteatoma10.2MMP9, MMP8
36plasmacytoma10.2IL6ST, IL6, IL6R
37choriocarcinoma10.2IL6ST, IL6R, INHA
38psoriatic arthritis10.2MMP1, CRP
39respiratory failure10.2CRP, IL6
40peritonitis10.2IL6, CRP, MMP8
41keratoconus10.2MMP8, MMP1
42adult respiratory distress syndrome10.2IL6, IL8
43middle ear cholesteatoma10.1MMP9, MMP1
44coronary artery anomaly10.1CRP, IL6, MMP8
45kawasaki disease10.1CRP, MMP9
46esophageal cancer10.1IL6ST, MMP1, INHBA
47bacterial meningitis10.1CRP, IL8, MMP8
48vernal keratoconjunctivitis10.1IL8, MMP9
49colitis10.1IL6, IL8, IL6R
50pheochromocytoma10.1IL6ST, IL6R, INHA, INHBA

Graphical network of the top 20 diseases related to Preterm Premature Rupture of the Membranes:



Diseases related to preterm premature rupture of the membranes

Symptoms for Preterm Premature Rupture of the Membranes

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Clinical features from OMIM:

610504

HPO human phenotypes related to Preterm Premature Rupture of the Membranes:

id Description Frequency HPO Source Accession
1 premature rupture of membranes HP:0001788
2 polygenic inheritance HP:0010982

Drugs & Therapeutics for Preterm Premature Rupture of the Membranes

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Drug clinical trials:

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Genetic Tests for Preterm Premature Rupture of the Membranes

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Anatomical Context for Preterm Premature Rupture of the Membranes

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MalaCards organs/tissues related to Preterm Premature Rupture of the Membranes:

32
Placenta, Testes, Colon, Cervix

Animal Models for Preterm Premature Rupture of the Membranes or affiliated genes

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MGI Mouse Phenotypes related to Preterm Premature Rupture of the Membranes:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0IL6R, INHA, MMP9, MMP8, MMP1, IL6ST
2MP:00053817.8INHA, INHBA, SERPINH1, MMP9, IL6ST, IL6
3MP:00053857.8INHA, SERPINH1, MMP9, IL6ST, IL6, CRP
4MP:00107717.6IL6, IL6ST, RLN1, MMP9, INHBA
5MP:00053797.5INHA, INHBA, RLN1, IL6ST, IL6, IL6R
6MP:00053907.2INHA, INHBA, SERPINH1, MMP9, RLN1, IL6ST
7MP:00053977.2INHA, INHBA, MMP9, IL6ST, IL8, IL6
8MP:00053877.2INHA, MMP9, MMP8, MMP1, IL6ST, IL8
9MP:00053786.8INHA, INHBA, SERPINH1, MMP9, RLN1, IL6ST
10MP:00107686.6INHA, INHBA, SERPINH1, MMP9, RLN1, IL6ST
11MP:00053766.4INHA, INHBA, MMP9, MMP1, RLN1, IL6ST

Publications for Preterm Premature Rupture of the Membranes

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Articles related to Preterm Premature Rupture of the Membranes:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
The chorion layer of fetal membranes is prematurely destroyed in women with preterm premature rupture of the membranes. (23536574)
2013
2
The impact of tobacco use on preterm premature rupture of the membranes. (22930157)
2013
3
Early planned birth may reduce neonatal sepsis compared to expectant management following preterm premature rupture of the membranes close to term. (23125240)
2013
4
Optimum mode of delivery in gestations complicated by preterm premature rupture of the membranes. (21854136)
2012
5
Maternal plasma prolidase, matrix metalloproteinases 1 and 13, and oxidative stress levels in pregnancies complicated by preterm premature rupture of the membranes and chorioamnionitis. (24592033)
2012
6
Antibiotics after preterm premature rupture of the membranes. (21508705)
2011
7
Correlation of myometrial thickness and the latency interval of women with preterm premature rupture of the membranes. (21298281)
2011
8
Amniotic fluid concentrations of soluble scavenger receptor for hemoglobin (sCD163) in pregnancy complicated by preterm premature rupture of the membranes and histologic chorioamnionitis. (21158489)
2011
9
Precipitated egg white as a sealant for iatrogenic preterm premature rupture of the membranes. (19942207)
2010
10
Influence of oligohydramnios on preterm premature rupture of the membranes at 30 to 36 weeks' gestation. (21176313)
2010
11
Neonatal outcomes after elective delivery management of preterm premature rupture of the membranes before 34 weeks' gestation (DOMINOS study). (19167805)
2009
12
Preterm premature rupture of the membranes and genital mycoplasmas. (20073423)
2009
13
The management of preterm premature rupture of the membranes near the limit of fetal viability. (19733274)
2009
14
Outcomes following prolonged preterm premature rupture of the membranes. (17660215)
2008
15
Amniocentesis in the management of preterm premature rupture of the membranes: a retrospective cohort analysis. (18609359)
2008
16
Modeling the duration of the latency period after preterm premature rupture of the membranes according to maternal and pregnancy characteristics: DOMINOS study. (18378062)
2008
17
Infection and the role of inflammation in preterm premature rupture of the membranes. (17448730)
2007
18
Increased intrauterine frequency of Ureaplasma urealyticum in women with preterm labor and preterm premature rupture of the membranes and subsequent cesarean delivery. (16260207)
2005
19
Preterm premature rupture of the membranes: diagnosis and management. (15519427)
2004
20
Outcomes after expectant management of extremely preterm premature rupture of the membranes. (14749657)
2004
21
Fetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathways. (15493713)
2004
22
Serum homocysteine levels after preterm premature rupture of the membranes. (15343233)
2004
23
Preterm premature rupture of the membranes is associated with a reduction in neonatal respiratory distress syndrome. (12193910)
2002
24
Fetal plasma MMP-9 concentrations are elevated in preterm premature rupture of the membranes. (12439489)
2002
25
Cost-effectiveness of induction after preterm premature rupture of the membranes. (12439494)
2002
26
Antenatal corticosteroids in women with preterm premature rupture of the membranes. (11817190)
2001
27
Persistent detection of alfa-fetoprotein in the vagina without overt preterm premature rupture of the membranes. Clinical and chemical characterizations. (11509846)
2001
28
Blood flow velocity waveforms from fetal peripheral pulmonary arteries in pregnancies with preterm premature rupture of the membranes: relationship with pulmonary hypoplasia. (10775989)
2000
29
Amniotic fluid index values after preterm premature rupture of the membranes and subsequent perinatal infection. (10942458)
2000
30
Effectiveness of antenatal corticosteroid administration after preterm premature rupture of the membranes. (11035339)
2000
31
Neonatal outcome following early onset preterm premature rupture of the membranes--a case controlled study. (10770110)
1999
32
Role of amniocentesis for the diagnosis of subclinical intra-amniotic infection in preterm premature rupture of the membranes. (10674829)
1999
33
Interleukin-6 concentrations in cervical secretions in the prediction of intrauterine infection in preterm premature rupture of the membranes. (9701687)
1998
34
Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. A randomized controlled trial. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. (9307346)
1997
35
Antibiotic therapy for preterm premature rupture of the membranes. (8912997)
1996
36
Antibiotic prophylaxis for presumptive group B streptococcal infection in preterm premature rupture of the membranes: effect on neonatal and maternal infectious morbidity. (18476117)
1996
37
Diagnosis of preterm premature rupture of the membranes using a newly developed AFP monoclonal antibody test kit. (7538939)
1995
38
Pregnancy outcome following preterm premature rupture of the membranes at less than 26 weeks' gestation. (1520195)
1992
39
Erythromycin therapy in preterm premature rupture of the membranes: a prospective, randomized trial of 220 patients. (1550145)
1992
40
Pregnancy outcome of preterm premature rupture of the membranes before 28 weeks. (1295650)
1992
41
The relationships among umbilical artery velocimetry, fetal biophysical profile, and placental inflammation in preterm premature rupture of the membranes. (1986622)
1991
42
Prolongation of the latency period in preterm premature rupture of the membranes using prophylactic antibiotics and tocolysis. (2213264)
1990
43
Symptoms that precede preterm labor and preterm premature rupture of the membranes. (2137968)
1990
44
Fetal behavior in preterm premature rupture of the membranes. (2673615)
1989
45
Does prolonged preterm premature rupture of the membranes predispose to abruptio placentae? (2668817)
1989
46
Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes. (3421266)
1988
47
The role of cervical cerclage in the management of preterm premature rupture of the membranes. (3337156)
1988
48
Is C-reactive protein really useful in preterm premature rupture of the membranes? (3426987)
1987
49
Preterm premature rupture of the membranes. (3815932)
1986
50
Amniocentesis for gram stain and culture in preterm premature rupture of the membranes. (2410839)
1985

Variations for Preterm Premature Rupture of the Membranes

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Clinvar genetic disease variations for Preterm Premature Rupture of the Membranes:

6
id Gene Name Type Significance SNP ID Assembly Location
1MMP8MMP8, HAPLOTYPE, TGGsingle nucleotide variantPathogenic
2MMP1NM_002421.3(MMP1): c.-1673G=insertionPathogenicrs1799750GRCh37Chr 11, 102670496: 102670496
3SERPINH1SERPINH1, -656C-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Preterm Premature Rupture of the Membranes

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Expression patterns in normal tissues for genes affiliated with Preterm Premature Rupture of the Membranes

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Pathways for genes affiliated with Preterm Premature Rupture of the Membranes

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Pathways related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7MMP1, MMP9
29.7MMP1, MMP9
39.7MMP1, IL6ST
49.6IL6, IL8
59.6IL6, IL8
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.5IL6ST, CRP
7
Show member pathways
9.4MMP1, MMP8, MMP9
89.3MMP1, IL8, IL6
99.3IL6, IL8, MMP1
109.3IL6, IL8, MMP1
119.3IL6R, IL6, IL8
12
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.2IL6ST, IL6, IL6R
13
Show member pathways
9.2IL6R, IL6, IL6ST
14
Show member pathways
Type III interferon signaling37
9.2IL6R, IL6, IL6ST
15
Show member pathways
9.2IL6ST, IL6, IL6R
169.2IL6ST, IL6, IL6R
17
Show member pathways
9.2IL6ST, IL6, IL6R
18
Show member pathways
9.2IL6R, IL6, IL6ST
199.2IL6ST, IL6, IL6R
20
Show member pathways
Signaling Pathways in Glioblastoma37
9.2MMP9, MMP1, IL8
219.1MMP9, IL8, IL6
22
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1IL6, IL8, MMP9
239.1IL6, IL8, MMP9
249.1IL6, IL8, MMP9
25
Show member pathways
9.1SERPINH1, MMP9, MMP8, MMP1
26
Show member pathways
9.0IL6, MMP1, MMP8, MMP9
278.9IL6R, IL6, MMP1, MMP9
28
Show member pathways
8.9IL8, MMP1, MMP8, MMP9
29
Show member pathways
8.9MMP9, MMP8, MMP1, IL8
308.8CRP, IL6R, IL6, IL6ST
318.8MMP9, MMP1, IL8, IL6
328.8MMP9, MMP1, IL8, IL6
33
Show member pathways
8.8IL6ST, IL8, IL6, IL6R
34
Show member pathways
8.6INHA, INHBA, MMP1, IL8
35
Show member pathways
8.0IL6R, IL6, IL8, IL6ST, INHBA
368.0IL6R, IL6, IL8, IL6ST, INHBA

Compounds for genes affiliated with Preterm Premature Rupture of the Membranes

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Compounds related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show top 50)    (show all 145)
idCompoundScoreTop Affiliating Genes
1clodronate44 50 1111.8IL6, MMP8, MMP1
2tocilizumab44 1110.8CRP, IL6, IL6R
3pamidronate44 50 1111.7IL6, CRP, MMP1
4(4-aminophenyl)mercuric acetate449.7MMP9, MMP8, MMP1
5u0126449.7IL6, IL8, MMP1
6gm 6001619.7MMP8, MMP9, MMP1
7gi 254023x619.7MMP1, MMP9, MMP8
8uk 383367619.6MMP1, MMP8, MMP9
9cilomilast449.6IL8, MMP1, MMP9
10marimastat44 61 1111.5MMP9, MMP8, MMP1
11hydroxamate449.5MMP9, MMP8, IL6R, MMP1
12etanercept44 50 1111.4CRP, MMP1, IL8, IL6
13zoledronic acid449.3IL6, MMP1, MMP9
14neopterin449.3IL6, CRP, IL8, IL6R
15fluvastatin44 50 28 1112.3MMP9, MMP1, IL6, CRP
16pioglitazone28 44 50 1112.3CRP, IL6, MMP1, MMP9
17pdtc449.2IL8, IL6, MMP9, MMP1
18aprotinin44 1110.2MMP1, IL6, IL8, MMP9
19atorvastatin44 50 28 24 1113.2IL6, CRP, MMP9, MMP1
20rosiglitazone28 44 50 24 1113.2MMP9, CRP, IL6, MMP1
21gabexate mesilate449.2IL6, IL8, MMP9, CRP
22sp 60012544 6110.2IL6, MMP9, IL8, MMP1
238-isoprostane449.1MMP9, IL6, CRP, IL8
24ciglitazone44 2810.1MMP9, IL8, IL6
25troglitazone44 28 61 1112.1MMP1, IL6, MMP9, IL8
26herbimycin a44 6110.0MMP1, IL8, IL6, MMP9
27hyaluronic acid44 2410.0IL6, IL8, MMP1, MMP9
28prednisolone44 28 1111.0MMP1, IL6ST, IL6, CRP, IL6R
29methotrexate50 44 1110.9IL6R, IL6, MMP1, CRP, MMP9
30simvastatin44 50 61 28 24 1113.9MMP9, IL8, IL6, CRP
31fibrinogen448.9CRP, IL6, IL6R, MMP8, MMP9
32rantes448.9MMP9, IL6, IL6R, IL8, MMP1
33ribonucleic acid448.9IL6ST, MMP1, MMP9, INHA, IL6R
34n acetylcysteine448.8IL8, IL6, MMP9, CRP, MMP1
35sb 20358044 619.8MMP9, MMP1, IL8, CRP, IL6
36curcumin448.7MMP9, MMP1, IL8, IL6
37lactate448.5IL8, IL6, MMP9, MMP8, CRP, MMP1
38genistein44 28 61 2 24 1113.4MMP1, IL6ST, IL8, IL6, MMP8, MMP9
39cyclosporin a44 28 6110.4MMP8, MMP9, MMP1, IL8, IL6, IL6R
40dexamethasone44 50 28 1111.3IL6R, MMP9, MMP1, IL8, IL6ST, IL6
41alanine448.3MMP8, IL6, IL6ST, INHA, MMP9, CRP
42progesterone44 28 61 24 1112.3MMP8, IL6ST, MMP1, IL6R, INHA, INHBA
43creatinine448.2MMP1, MMP9, CRP, IL6R, IL6
44retinoic acid44 249.1IL6R, IL6, IL6ST, MMP1, MMP8, MMP9
45pge2448.1IL6, IL8, IL6ST, MMP1, MMP8, MMP9
46oligonucleotide448.0MMP1, IL6R, INHBA, INHA, MMP8, SERPINH1
47testosterone44 61 24 1110.8MMP1, MMP9, CRP, IL6R, IL6, INHBA
48estrogen447.7MMP1, IL6, INHBA, MMP9, IL6ST, INHA
49vegf447.4CRP, SERPINH1, MMP9, MMP8, MMP1, IL6ST
50cycloheximide447.2INHBA, MMP9, MMP1, IL6ST, IL6, IL6R

GO Terms for genes affiliated with Preterm Premature Rupture of the Membranes

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Cellular components related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.4MMP1, MMP8, MMP9
2interleukin-6 receptor complexGO:0058969.1IL6ST, IL6, IL6R
3inhibin A complexGO:0435129.0INHBA, INHA
4extracellular spaceGO:0056157.3SERPINH1, MMP9, MMP8, IL6ST, IL8, IL6
5extracellular regionGO:0055765.6CRP, INHA, INHBA, MMP9, MMP8, MMP1

Biological processes related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1hepatic immune responseGO:00238410.2IL6R, IL6
2negative regulation of collagen biosynthetic processGO:03296610.1IL6, IL6R
3neutrophil mediated immunityGO:00244610.1IL6, IL6R
4positive regulation of leukocyte chemotaxisGO:00269010.1IL6R, IL6
5positive regulation of chemokine productionGO:03272210.0IL6R, IL6
6negative regulation of lipid storageGO:01088810.0CRP, IL6
7monocyte chemotaxisGO:00254810.0IL6R, IL6
8ciliary neurotrophic factor-mediated signaling pathwayGO:07012010.0IL6ST, IL6R
9defense response to Gram-negative bacteriumGO:05082910.0IL6, IL6R
10positive regulation of acute inflammatory responseGO:0026759.9IL6, IL6ST
11positive regulation of interleukin-6 productionGO:0327559.9IL6, IL6R
12endocrine pancreas developmentGO:0310189.8IL6, IL6R
13defense response to Gram-positive bacteriumGO:0508309.8CRP, IL6R, IL6
14acute-phase responseGO:0069539.8IL6, IL6R, CRP
15collagen catabolic processGO:0305749.7MMP9, MMP8, MMP1
16negative regulation of follicle-stimulating hormone secretionGO:0468829.7INHA, INHBA
17positive regulation of follicle-stimulating hormone secretionGO:0468819.7INHA, INHBA
18negative regulation of B cell differentiationGO:0455789.7INHA, INHBA
19negative regulation of interferon-gamma biosynthetic processGO:0450779.7INHA, INHBA
20hemoglobin biosynthetic processGO:0425419.7INHA, INHBA
21extracellular matrix disassemblyGO:0226179.7MMP1, MMP8, MMP9
22negative regulation of macrophage differentiationGO:0456509.7INHA, INHBA
23interleukin-6-mediated signaling pathwayGO:0701029.6IL6R, IL6, IL6ST
24positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.6IL6ST, IL6, IL6R
25positive regulation of osteoblast differentiationGO:0456699.6IL6R, IL6, IL6ST
26proteolysisGO:0065089.6MMP1, MMP8, MMP9
27negative regulation of phosphorylationGO:0423269.6INHA, INHBA
28extrinsic apoptotic signaling pathwayGO:0971919.5INHBA, IL6R
29erythrocyte differentiationGO:0302189.5INHBA, INHA
30extracellular matrix organizationGO:0301989.5MMP1, MMP8, MMP9, SERPINH1
31positive regulation of smooth muscle cell proliferationGO:0486619.5IL6R, IL6
32cytokine-mediated signaling pathwayGO:0192219.4IL6R, IL6, IL6ST
33ovarian follicle developmentGO:0015419.3INHBA, INHA
34inflammatory responseGO:0069549.2CRP, IL6, IL8
35negative regulation of cell cycleGO:0457869.2INHA, INHBA
36cell cycle arrestGO:0070509.2INHA, INHBA, IL8

Molecular functions related to Preterm Premature Rupture of the Membranes according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1interleukin-6 bindingGO:0199819.8IL6ST, IL6R
2interleukin-6 receptor activityGO:0049159.8IL6ST, IL6R
3ciliary neurotrophic factor receptor activityGO:0048979.7IL6R, IL6ST
4interleukin-6 receptor bindingGO:0051389.4IL6R, IL6, IL6ST
5metalloendopeptidase activityGO:0042229.4MMP9, MMP8, MMP1
6growth factor activityGO:0080838.9IL6, INHBA, INHA
7hormone activityGO:0051798.8RLN1, INHBA, INHA
8cytokine activityGO:0051258.7INHA, INHBA, IL6
9protein bindingGO:0055156.7INHBA, MMP9, IL6ST, IL8, IL6, IL6R

Products for genes affiliated with Preterm Premature Rupture of the Membranes

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Sources for Preterm Premature Rupture of the Membranes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet