MCID: PRP007
MIFTS: 60

Priapism malady

Genetic diseases, Rare diseases, Reproductive diseases, Cardiovascular diseases categories
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Summaries for Priapism

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Priapism (/?pra??p?z?m/) is a potentially painful medical condition in which the erect penis does not... more...

MalaCards: Priapism, also known as priapism, familial idiopathic, is related to sickle cell disease and sickle cell anemia. An important gene associated with Priapism is GLA (galactosidase, alpha), and among its related pathways are O2/CO2 exchange in erythrocytes and Effects of nitric oxide. The compounds hg2+ and lactose have been mentioned in the context of this disorder. Affiliated tissues include prostate, myeloid and spinal cord, and related mouse phenotypes are digestive/alimentary and respiratory system.

Disease Ontology:8 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

Aliases & Classifications for Priapism

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
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Classifications:



Aliases & Descriptions:

priapism 8 43 10 45 62
priapism, familial idiopathic 43 62
familial idiopathic priapism 43
mentulagra 8


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Disease Ontology8 DOID:9286
MeSH35 D011317
ICD9CM27 607.3
NCIt40 C85022
ICD1025 N48.3

Related Diseases for Priapism

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17GeneCards, 18GeneDecks
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Diseases related to Priapism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease30.9NOS3, HP, G6PD, GLA
2sickle cell anemia30.8HP, G6PD
3hypertension30.1NOS3, PDE5A, F5
4impotence30.1PDE5A, NOS3, NOS2
5hemoglobinopathy30.0G6PD, HP
6hereditary spherocytosis30.0SLC4A1, G6PD
7peyronie's disease29.9PDE5A, NOS2
8thromboembolism29.8F5, G6PD, NOS3
9low-flow priapism10.6
10leukemia10.4
11prostatitis10.3
12adenocarcinoma10.2
13spinal cord injury10.2
14chronic myeloid leukemia10.2
15myeloid leukemia10.2
16prostate cancer10.2
17purpura10.2
18schizophrenia10.2
19protein c deficiency10.1
20thalassemia10.1
21peyronies disease10.1PDE5A
22blood group incompatibility10.1G6PD
23blackwater fever10.1G6PD
24mediterranean spotted fever10.1G6PD
25kernicterus10.1G6PD
26sexual disorder10.1GNRH1, PDE5A
27acute chest syndrome10.1NOS3
28congenital hemolytic anemia10.1G6PD, HP
29favism10.1G6PD, HP
30glucosephosphate dehydrogenase deficiency10.1G6PD, HP
31hemoglobinuria10.1HP, G6PD
32hereditary elliptocytosis10.1SLC4A1, G6PD
33central retinal vein occlusion10.1F5
34placental abruption10.1F5
35factor vii deficiency10.1F5
36autoimmune hemolytic anemia10.1G6PD, HP
37methemoglobinemia10.1G6PD, HP
38paroxysmal nocturnal hemoglobinuria10.1G6PD, HP
39bilirubin metabolic disorder10.1HP, G6PD
40congenital heart disease10.1HP, GLA, PDE5A
41alpha thalassemia10.1G6PD, SLC4A1
42hemolytic anemia10.1G6PD, HP, SLC4A1
43malaria10.1SLC4A1, HP, G6PD
44arteriosclerosis10.1NOS3
45hellp syndrome10.0F5, HP
46primary hyperoxaluria10.0GLA, G6PD, HP
47factor xii deficiency10.0F5, F13A1
48coronary artery disease10.0HP, PDE5A, NOS3
49ovarian hyperstimulation syndrome10.0GNRH1, F5
50dysfibrinogenemia10.0F13A1, F5

Graphical network of the top 20 diseases related to Priapism:



Diseases related to priapism

Symptoms for Priapism

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Drugs & Therapeutics for Priapism

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Priapism

Search NIH Clinical Center for Priapism

Genetic Tests for Priapism

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Anatomical Context for Priapism

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33MalaCards
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MalaCards organs/tissues related to Priapism:

33
Prostate, Myeloid, Spinal cord, Skin, Smooth muscle, Brain, Kidney, Testes, T cells

Animal Models for Priapism or affiliated genes

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37MGI
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Publications for Priapism

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52PubMed
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Articles related to Priapism:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism. (24076963)
2014
2
Priapism Induced by Boceprevir-CYP3A4 Inhibition and I+-Adrenergic Blockade: Case Report. (24092799)
2014
3
18F-FDG PET/CT in a case of malignant priapism secondary to metastasis from mucoid adenocarcinoma of the cecum. (23334147)
2013
4
Unsatisfactory outcomes of prolonged ischemic priapism without early surgical shunts: our clinical experience and a review of the literature. (22922321)
2013
5
Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress. (23844149)
2013
6
Priapism in children: a comprehensive review and clinical guideline. (24135215)
2013
7
High flow priapism on color Doppler ultrasound. (23473902)
2013
8
A pathophysiology-based approach to the management of early priapism. (23202699)
2013
9
Castration for treating recurrent priapism: can we do better? (21799141)
2012
10
Priapism: comorbid factors and treatment outcomes in a contemporary series. (22811705)
2012
11
The use of sudafed for priapism in pediatric patients with sickle cell disease. (22041221)
2012
12
How I manage priapism in chronic myeloid leukaemia patients. (22571386)
2012
13
High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. (19912496)
2011
14
Treating stuttering priapism. (21914108)
2011
15
Early insertion of inflatable prosthesis for intractable ischemic priapism: our experience and review of the literature. (21654814)
2011
16
Daily phosphodiesterase type 5 inhibitor therapy as rescue for recurrent ischemic priapism after failed androgen ablation. (21127306)
2011
17
A crackling priapism related to Fournier's gangrene in a patient on chronic peritoneal dialysis. (20600298)
2010
18
Antipsychotic-induced priapism in an HIV patient: a cytochrome P450-mediated drug interaction. (20606815)
2010
19
Favorable response to intrathecal, but not oral, baclofen of priapism in a patient with spinal cord injury. (19179913)
2009
20
Posttraumatic high-flow priapism: case report, current management options and literature review. (19623873)
2009
21
Ketoconazole and prednisone to prevent recurrent ischemic priapism. (19683289)
2009
22
Investigating the effects of high-dose phenylephrine in the management of prolonged ischaemic priapism. (18466270)
2008
23
Posttraumatic nonischemic priapism treated with autologous blood clot embolization. (18173765)
2008
24
Sickle cell trait and priapism: a case report and review of the literature. (19116025)
2008
25
Glucose-6-phosphate dehydrogenase deficiency associated stuttering priapism: report of a case. (18823322)
2008
26
Sickle cell disease status and outcomes of African-American men presenting with priapism. (18312286)
2008
27
Superselective arterial embolization for patients with high-flow priapism: results of follow-up for five or more years. (17453510)
2007
28
Association between priapism and concurrent use of risperidone and Ginkgo biloba. (17908535)
2007
29
Priapism in the oncology setting. (17441393)
2007
30
The Winter procedure as management for prolonged low-flow priapism: a case report. (18055300)
2007
31
Stuttering priapism after ingestion of alfuzosin. (17070382)
2006
32
High-flow priapism as a complication of a veno-occlusive priapism: two case reports. (16224494)
2006
33
Priapism: new concepts in the pathophysiology and new treatment strategies. (17052448)
2006
34
Is the combination of superselective transcatheter autologous clot embolization and duplex sonography-guided compression therapy useful treatment option for the patients with high-flow priapism? (16079900)
2006
35
Distal cavernosum-glans shunts for ischemic priapism. (16839333)
2006
36
Irreversible priapism during olanzapine and lithium therapy. (15144518)
2004
37
Priapism following ingestion of tamsulosin. (12771780)
2003
38
Priapism secondary to hypertriglyceridemia. (12576856)
2003
39
Evidence-based radiology problems. High-flow post-traumatic priapism: transcatheter embolotherapy: October 2003-September 2004. (14593770)
2003
40
The incidence and management of priapism in Western Australia: a 16 year audit. (12934055)
2003
41
Priapism associated with two atypical antipsychotic agents. (12173794)
2002
42
Management strategy for arterial priapism: therapeutic dilemmas. (12394712)
2002
43
Interventional treatment of traumatic priapism. (12431145)
2002
44
The management of low-flow priapism with the immediate insertion of a penile prosthesis. (12460352)
2002
45
Unusual complications of warfarin therapy: skin necrosis and priapism. (10931425)
2000
46
Re: Chronic myeloid leukaemia presenting as priapism in children: need for multidisciplinary approach. (12862132)
2000
47
Priapism in a patient with protein C deficiency. (9352148)
1997
48
Permanent open shunt as a reason for impotence or reduced potency after surgical treatment of priapism in 26 patients. (8750051)
1995
49
Priapism associated with chronic cocaine abuse. (8042894)
1994
50
Priapism associated with intranasal cocaine abuse. (2304177)
1990

Variations for Priapism

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Expression for genes affiliated with Priapism

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for genes affiliated with Priapism

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 51PharmGKB, 5Cell Signaling Technology, 61Tocris Bioscience, 60Thomson Reuters, 53QIAGEN, 30KEGG
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Pathways related to Priapism according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9AQP1, SLC4A1
2
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis38
9.5NOS3, NOS2
39.5NOS3, NOS2
4
Show member pathways
9.5NOS3, NOS2
59.1TGFBR3, ITGAV, NOS3
6
Show member pathways
9.1NOS3, ITGAV, TGFBR3
7
Show member pathways
8.9NOS3, NOS2, PDE5A
88.9NOS3, NOS2, PDE5A
9
Show member pathways
8.9PDE5A, NOS2, NOS3
10
Show member pathways
8.7NOS3, ITGAV, TGFBR3, GNRH1
118.7ADORA2B, NOS2, NOS3
12
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
8.6ADORA2B, ITGAV, NOS3
13
Show member pathways
8.2AQP1, G6PD, KL, GLA, NOS2, NOS3
14
Show member pathways
7.6NOS3, F13A1, ITGAV, PDE5A, F5, NOS2

Compounds for genes affiliated with Priapism

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45Novoseek, 11DrugBank, 61Tocris Bioscience, 24HMDB, 51PharmGKB, 29IUPHAR
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Compounds related to Priapism according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1hg2+4510.3AQP1, GLA
2lactose45 1110.9HP, GLA, G6PD
3magnesium lithospermate b459.9NOS2, NOS3
4l-thiocitrulline45 1110.9NOS2, NOS3
5s-ethylisothiourea45 1110.9NOS2, NOS3
6n5-(1-iminoethyl)-l-ornithine459.8NOS2, NOS3
7nitrit459.8NOS2, NOS3
8n-(3-(aminomethyl)benzyl)acetamidine45 1110.8NOS2, NOS3
9n(g)-hydroxy-l-arginine459.8NOS3, NOS2
103-bromo-7-nitroindazole61 1110.8NOS2, NOS3
117-nitroindazole45 1110.8NOS3, NOS2
12kininogen459.7F13A1, HP, F5
13vitamin b12459.6HP, G6PD, F5
14malondialdehyde459.6F5, G6PD, HP
15urea45 24 1111.6F5, HP, AQP1, F13A1
16glycerol45 24 1111.6G6PD, NOS3, AQP1, GLA
17raloxifene45 51 29 1112.5NOS3, GNRH1, F5
18pentoxifylline45 1110.5GNRH1, HP, PDE5A
19diphenyleneiodonium459.5NOS2, G6PD, NOS3
20phospholipid459.4F5, GLA, AQP1, SLC4A1, HP
21epinephrine45 24 1111.4GNRH1, G6PD, F5, HP
22n(g),n(g)-dimethylarginine459.4NOS3, NOS2
23aspartate459.3F5, G6PD, HP, GLA, GNRH1
24vitamin-e459.3G6PD, PDE5A, F5, HP
25kt 582345 2910.3PDE5A, NOS2, NOS3
26sildenafil29 45 51 24 1113.3NOS3, PDE5A, NOS2
27nitroglycerin45 1110.2NOS3, PDE5A, NOS2
28peroxynitrite459.2SLC4A1, NOS2, NOS3
29nitrate459.2PDE5A, NOS3, NOS2
30citrate459.1SLC4A1, NOS3, F5, HP, G6PD
31creatinine459.1GLA, F5, HP, G6PD, GNRH1, AQP1
32lactate459.1GLA, F5, HP, G6PD, GNRH1, SLC4A1
33aspirin45 51 29 2412.1HP, F13A1, G6PD, NOS3, F5
34cgmp45 2910.0NOS2, NOS3, AQP1, PDE5A
35actinomycin d459.0NOS2, NOS3, GNRH1, HP, G6PD
36tamoxifen45 51 29 1112.0F5, GNRH1, G6PD, NOS3
37ascorbic acid45 249.9NOS3, NOS2, F5, G6PD, HP
38prostacyclin458.9NOS3, F5, PDE5A, NOS2
39testosterone45 61 24 1111.7GNRH1, G6PD, HP, PDE5A, F5
40fibrinogen458.6ITGAV, F5, HP, F13A1
41adenylate458.6NOS2, HP, ADORA2B, GNRH1, G6PD
42pge1458.6F5, PDE5A, ADORA2B
43folate458.5PDE5A, G6PD, SLC4A1, NOS3, HP, F5
44sodium nitroprusside458.4GNRH1, AQP1, PDE5A, NOS2, NOS3, G6PD
45arginine458.1GNRH1, NOS3, NOS2, GLA, PDE5A, F5
46nitric oxide45 24 119.9GLA, NOS2, NOS3, PDE5A, HP, AQP1
47estrogen457.7NOS2, F5, PDE5A, HP, G6PD, F13A1
48glutamate457.6NOS2, NOS3, SLC4A1, F5, HP, ADORA2B
49vegf457.3NOS3, F13A1, AQP1, ITGAV, HP, PDE5A
50calcium45 51 24 119.2AQP1, F13A1, ADORA2B, ITGAV, NOS3, NOS2

GO Terms for genes affiliated with Priapism

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16Gene Ontology
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Cellular components related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cortical cytoskeletonGO:0308639.7SLC4A1, NOS2
2blood microparticleGO:0725629.5SLC4A1, HP, F13A1
3extracellular regionGO:0055768.7F13A1, GNRH1, HP, F5, KL, GLA
4extracellular spaceGO:0056158.6GNRH1, TGFBR3, HP, F5, KL
5extracellular vesicular exosomeGO:0700628.3SLC4A1, TGFBR3, AQP1, G6PD, ITGAV, HP
6integral component of plasma membraneGO:0058878.0TGFBR3, AQP1, ADORA2B, ITGAV, KL, SLC4A1

Biological processes related to Priapism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1bicarbonate transportGO:0157019.8SLC4A1, AQP1
2arginine catabolic processGO:0065279.7NOS3, NOS2
3nitric oxide biosynthetic processGO:0068099.6NOS3, NOS2
4nitric oxide mediated signal transductionGO:0072639.6NOS2, NOS3
5negative regulation of blood pressureGO:0457769.6NOS3, NOS2
6positive regulation of vasodilationGO:0459099.5NOS3, NOS2
7interaction with hostGO:0517019.2NOS2, NOS3
8positive regulation of guanylate cyclase activityGO:0312848.9NOS3, NOS2, ADORA2B
9small molecule metabolic processGO:0442818.9SLC4A1, NOS3, GLA, G6PD, AQP1
10blood coagulationGO:0075967.8F13A1, ITGAV, PDE5A, F5, NOS2, NOS3

Molecular functions related to Priapism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:0045179.7NOS3, NOS2
2arginine bindingGO:0346189.7NOS2, NOS3
3tetrahydrobiopterin bindingGO:0346179.6NOS2, NOS3
4NADPH-hemoprotein reductase activityGO:0039589.6NOS3, NOS2
5transforming growth factor beta bindingGO:0504319.6TGFBR3, ITGAV
6fibroblast growth factor bindingGO:0171349.6KL, TGFBR3
7NADP bindingGO:0506619.4NOS3, NOS2, G6PD
8FMN bindingGO:0101819.4NOS2, NOS3
9protein homodimerization activityGO:0428039.2SLC4A1, NOS2, GLA, G6PD
10protein bindingGO:0055156.9TGFBR3, AQP1, G6PD, ITGAV, HP, F5

Products for genes affiliated with Priapism

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Sources for Priapism

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet