MCID: PRP007
MIFTS: 55

Priapism malady

Reproductive diseases, Genetic diseases categories

Summaries for Priapism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Priapism (/ˈpraɪəpɪzəm/) is a potentially painful medical condition in which the erect penis does... more...

MalaCards: Priapism, also known as priapism, familial idiopathic, is related to sickle cell disease and sickle cell anemia. An important gene associated with Priapism is GLA (galactosidase, alpha), and among its related pathways are O2/CO2 exchange in erythrocytes and Common Pathway. The compounds hg2+ and estrogen have been mentioned in the context of this disorder. Affiliated tissues include prostate, myeloid and spinal cord, and related mouse phenotypes are reproductive system and liver/biliary system.

Aliases & Classifications for Priapism

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

priapism 8 42 10 44 60
priapism, familial idiopathic 42 60
familial idiopathic priapism 42
mentulagra 8


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Disease Ontology8 DOID:9286
ICD9CM27 607.3
MeSH34 D011317
NCIt39 C85022
ICD1025 N48.3

Related Diseases for Priapism

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Priapism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease30.8G6PD, GLA, HP, NOS3
2sickle cell anemia30.5HP, G6PD
3leukemia30.5HP
4prostatitis30.4PDE5A
5adenocarcinoma30.3NPR1, GUCY2C, F13A1, AQP1
6peritonitis30.0AQP1
7fabry disease30.0GLA
8hypertension29.9GUCY2C, NOS3, F5, NPR1, PDE5A
9premature ejaculation29.7PDE5A
10sarcoma29.7F13A1
11hypogonadism29.7GNRH1, PDE5A
12hemoglobinopathy29.7HP, G6PD
13hereditary spherocytosis29.7G6PD, SLC4A1
14antiphospholipid syndrome29.7F5
15polycystic kidney disease, autosomal dominant29.7NOS3, SLC4A1, AQP1
16chronic myeloid leukemia10.2
17myeloid leukemia10.2
18prostate cancer10.2
19purpura10.2
20schizophrenia10.2
21protein c deficiency10.1
22prostate adenocarcinoma10.1
23thalassemia10.1
24low-flow priapism10.1
25beta thalassemia10.0
26protein s deficiency10.0
27paraphimosis10.0
28cocaine abuse10.0
29impotence10.0
30systemic scleroderma10.0
31ischemic optic neuropathy10.0PDE5A
32hyperparathyroidism10.0KL
33vascular disease10.0HP
34hepatitis b10.0CFB
35age related macular degeneration10.0CFB
36pulmonary emphysema10.0KL
37arthritis10.0HP
38colon cancer10.0GUCY2C
39varicocele10.0GNRH1
40blackwater fever10.0G6PD
41polycystic ovary syndrome10.0GNRH1
42infertility10.0GNRH1
43migraine10.0PDE5A
44nephrotic syndrome10.0HP
45cerebrovascular disease10.0F13A1
46pancreatic cancer10.0HP
47hepatitis10.0HP, CFB
48alpha thalassemia10.0G6PD, SLC4A1
49pneumonia10.0PDE4A
50autoimmune hemolytic anemia10.0HP, G6PD

Graphical network of the top 20 diseases related to Priapism:



Diseases related to priapism

Clinical Features for Priapism

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Drugs & Therapeutics for Priapism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Priapism

Search NIH Clinical Center for Priapism

Search CenterWatch for Priapism

Genetic Tests for Priapism

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Anatomical Context for Priapism

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32MalaCards
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MalaCards organs/tissues related to Priapism:

32
Prostate, Myeloid, Spinal cord, Smooth muscle, Skin, Brain, Kidney, Testes, T cells

Animal Models for Priapism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Priapism:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5KL, GNRH1, NPR1, CFB, ADORA2B, AQP1
2MP:00053708.4KL, GNRH1, GUCY2C, F5, GLA, HP
3MP:00053678.2KL, GNRH1, ITGAV, GLA, HP, CFB
4MP:00053698.1KL, NPR1, ITGAV, GLA, SLC4A1, NOS3
5MP:00053787.5GNRH1, G6PD, GUCY2C, ITGAV, F5, BLM
6MP:00053977.4KL, GNRH1, G6PD, ITGAV, F13A1, BLM
7MP:00053847.0ITGAV, G6PD, NPR1, GNRH1, KL, BLM
8MP:00053766.6ITGAV, GUCY2C, G6PD, NPR1, GNRH1, KL
9MP:00107686.4F5, ITGAV, GUCY2C, G6PD, NPR1, KL
10MP:00053876.1ITGAV, GUCY2C, NPR1, PDE4A, GNRH1, KL
11MP:00053855.5TGFBR3, KL, PDE4A, NPR1, G6PD, GUCY2C

Publications for Priapism

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Sources:
50PubMed
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Articles related to Priapism:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Priapism after western black widow spider (Latrodectus hesperus) envenomation. (24412661)
2014
2
18F-FDG PET/CT in a case of malignant priapism secondary to metastasis from mucoid adenocarcinoma of the cecum. (23334147)
2013
3
Sodium Valproate induced priapism in an adult with bipolar affective disorder. (24347777)
2013
4
Ictal priapism as an autonomic manifestation of Panayiotopoulos syndrome. (23112246)
2013
5
Castration for treating recurrent priapism: can we do better? (21799141)
2012
6
Case of malignant priapism and review of the literature. (22439456)
2012
7
Priapism: pathophysiology and the role of the radiologist. (22960245)
2012
8
Postsurgical high flow priapism treated by transarterial embolizaton: a case report. (22379753)
2012
9
Priapism in acute spinal cord injury. (22231547)
2012
10
An adolescent with sickle cell anaemia experiencing disease-related complications: priapism and leg ulcer--a management challenge. (22605005)
2012
11
A case of priapism associated with rapid increase in risperidone dose. (23469322)
2012
12
Adrenergic I+-blockers: an infrequent and overlooked cause of priapism. (21593761)
2011
13
Heparin and prednisone-associated priapism: two case reports. (21219386)
2011
14
A crackling priapism related to Fournier's gangrene in a patient on chronic peritoneal dialysis. (20600298)
2010
15
Antipsychotic-induced priapism in an HIV patient: a cytochrome P450-mediated drug interaction. (20606815)
2010
16
Priapism associated with methylphenidate: a case report. (21043394)
2010
17
Stuttering priapism: case report and bibliographic review. (20945593)
2010
18
Structural analysis of the corpora cavernosa in patients with ischaemic priapism. (19751255)
2010
19
Ketoconazole and prednisone to prevent recurrent ischemic priapism. (19683289)
2009
20
Corporal "snake" maneuver: corporoglanular shunt surgical modification for ischemic priapism. (19207268)
2009
21
Colour Doppler ultrasound hemodynamic characteristics of patients with priapism before and after therapeutic interventions. (19672444)
2009
22
Adenosine signaling, priapism and novel therapies. (19267852)
2009
23
High-flow priapism in a 12-year-old boy: Treatment with superselective embolization. (19955685)
2009
24
Temporary cavernosal-cephalic vein shunt in low-flow priapism treatment. (18945541)
2009
25
Priapism in children: review of pathophysiology and treatment. (19455267)
2009
26
Glucose-6-phosphate dehydrogenase deficiency: an etiology for idiopathic priapism? (17971109)
2008
27
Priapism as a complication after total hip arthroplasty: a case report and review of the literature. (19292271)
2008
28
Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. (18340377)
2008
29
Management of priapism in a child with sickle cell anemia; successful outcome using epidural analgesia. (17666717)
2007
30
Priapism: current principles and practice. (17983902)
2007
31
Management of ischemic priapism with high-dose intracavernosal phenylephrine: from bench to bedside. (16942536)
2006
32
Recurrent priapism in the young patient treated with baclofen. (18947688)
2006
33
Evaluation of patients after treatment of arterial priapism with selective micro-embolization. (16452056)
2006
34
Does prolonged semi-erection in prepubertal high flow priapism result in increased penile size? (15806226)
2005
35
Tadalafil-associated priapism. (16051318)
2005
36
Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism. (15668387)
2005
37
Priapism associated with oxcarbazepine, aripiprazole, and lithium. (16292111)
2005
38
Priapism secondary to leukemia: effective management with prompt leukapheresis. (15379953)
2004
39
Occurrence of priapism with risperidone-paroxetine combination in an autistic child. (15650488)
2004
40
Treatments for priapism in boys and men with sickle cell disease. (15495085)
2004
41
Idiopathic priapism in a young boy. (12745751)
2003
42
Paraphimosis/priapism in rabbits. (12622297)
2003
43
Priapism in a patient with unstable hemoglobin: hemoglobin KAPln. (12949895)
2003
44
Priapism caused by infection and an inflammatory process in the pelvic region. (12660466)
2003
45
Successful treatment with clozapine at higher doses after clozapine-induced priapism. (14658959)
2003
46
Management strategy for arterial priapism: therapeutic dilemmas. (12394712)
2002
47
Risperidone-induced priapism. (12002369)
2002
48
Etilefrine for the prevention of priapism in adult sickle cell disease. (12181066)
2002
49
Acute priapism in a patient with unstable hemoglobin Perth and Factor V Leiden under effective oral anticoagulant therapy. (11920248)
2001
50
Re: Chronic myeloid leukaemia presenting as priapism in children: need for multidisciplinary approach. (12862132)
2000

Genetic Variations for Priapism

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Expression for genes affiliated with Priapism

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for genes affiliated with Priapism

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Compounds for genes affiliated with Priapism

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Priapism according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1hg2+4410.4AQP1, GLA
2estrogen4410.2F13A1, PDE5A
3cellulose acetate4410.1CFB, G6PD, HP
4lactose44 1110.9HP, G6PD, GLA
5urea44 11 2411.8HP, F13A1, AQP1, F5
6nitroglycerin44 1110.8NOS3, PDE5A, NPR1
7raloxifene44 28 49 1112.7GNRH1, NOS3, F5
8forskolin44 49 1111.7PDE5A, NPR1, ADORA2B
9vitamin-e449.6HP, F5, G6PD, PDE5A
10kininogen449.6F5, HP, F13A1
11motapizone449.6PDE5A, PDE4A
12glutamate449.6SLC4A1, NPR1, ADORA2B, GLA, GNRH1
13citrate449.5SLC4A1, NOS3, HP, F5, G6PD
14roflumilast44 1110.5PDE4A, PDE5A
15tamoxifen44 49 28 1112.5G6PD, PDE4A, GNRH1
16chloride449.5ADORA2B, AQP1, GUCY2C, SLC4A1
17enprofylline44 1110.5PDE4A, ADORA2B
18methylene449.4PDE4A, G6PD, F5
198-bromo cgmp449.4PDE4A, NPR1, PDE5A
20lactate449.4F5, GNRH1, G6PD, GLA, HP, SLC4A1
21vinpocetine44 2810.4PDE5A, PDE4A
22creatinine449.4HP, GNRH1, F5, G6PD, GLA, AQP1
23erythro-9-(2 hydroxy 3-nonyl)adenine449.4PDE4A, PDE5A
24aspartate449.3GLA, G6PD, PDE4A, GNRH1
25papaverine44 2 1111.3PDE4A, PDE5A, NOS3
26sodium44 2410.2SLC4A1, PDE5A, NPR1, AQP1, HP
27sildenafil44 49 28 11 2413.2PDE4A, PDE5A, NOS3
28serine449.2G6PD, HP, GLA, PDE4A, NPR1
29pentoxifylline44 1110.2GNRH1, HP, PDE5A, PDE4A
30glucose449.2AQP1, SLC4A1, CFB, PDE4A, GLA
31folate449.1G6PD, NOS3, SLC4A1, HP, F5, PDE5A
32glycerol44 11 2411.1G6PD, AQP1, GLA, PDE4A, NOS3
33epinephrine44 11 2411.0GNRH1, PDE4A, G6PD, F5, HP
34phospholipid448.9SLC4A1, HP, PDE4A, F5, GLA, AQP1
35hydrogen44 249.9AQP1, GLA, PDE5A, SLC4A1, PDE4A
36actinomycin d448.9HP, PDE4A, G6PD, GNRH1, NOS3
37pge1448.9ADORA2B, PDE4A, F5, PDE5A
38guanylate448.8PDE4A, PDE5A, NPR1, GUCY2C, NOS3
39prostacyclin448.8NOS3, PDE5A, PDE4A, F5
40alanine448.7AQP1, SLC4A1, HP, NPR1, F5, GNRH1
41xanthine44 249.7ADORA2B, PDE4A, NOS3
42cgmp44 289.7NPR1, PDE4A, PDE5A, GUCY2C, NOS3, AQP1
43aspirin44 49 28 2411.6G6PD, PDE4A, F5, F13A1, HP, NOS3
44glutamine448.6F13A1, G6PD, PDE5A, PDE4A, F5
45atp44 289.5SLC4A1, PDE4A, HP, NPR1, G6PD, GUCY2C
46sodium nitroprusside448.4GNRH1, AQP1, G6PD, NPR1, PDE5A, PDE4A
47arginine448.3AQP1, GNRH1, PDE4A, NOS3, GLA, F5
48nitric oxide44 11 2410.0PDE5A, SLC4A1, NOS3, NPR1, AQP1, HP
49vegf447.5F13A1, HP, NOS3, KL, F5, ITGAV
50calcium44 49 11 249.6ITGAV, F13A1, GLA, HP, NOS3, ADORA2B

GO Terms for genes affiliated with Priapism

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16Gene Ontology
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Cellular components related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8GNRH1, F5, F13A1, GLA, HP, CFB
2integral to plasma membraneGO:0058878.0TGFBR3, KL, NPR1, ITGAV, SLC4A1, ADORA2B

Biological processes related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.0AQP1, NPR1
2regulation of blood vessel sizeGO:0508809.9NOS3, NPR1
3positive regulation of cGMP biosynthetic processGO:0308289.8NPR1, ADORA2B
4positive regulation of guanylate cyclase activityGO:0312849.8ADORA2B, NOS3
5receptor guanylyl cyclase signaling pathwayGO:0071689.7GUCY2C, NPR1
6blood coagulationGO:0075968.5NOS3, F13A1, F5, ITGAV, PDE5A

Molecular functions related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanylate cyclase activityGO:0043839.9GUCY2C, NPR1
2transforming growth factor beta bindingGO:0504319.3TGFBR3, ITGAV
3protein bindingGO:0055156.4G6PD, GUCY2C, ITGAV, F5, BLM, GLA

Products for genes affiliated with Priapism

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  • Antibodies
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Sources for Priapism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet