MCID: PRP007
MIFTS: 60

Priapism malady

Genetic diseases, Rare diseases, Reproductive diseases, Cardiovascular diseases categories

Summaries for Priapism

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Priapism (/?pra??p?z?m/) is a potentially painful medical condition in which the erect penis does not... more...

MalaCards: Priapism, also known as priapism, familial idiopathic, is related to sickle cell disease and sickle cell anemia. An important gene associated with Priapism is GLA (galactosidase, alpha), and among its related pathways are O2/CO2 exchange in erythrocytes and Effects of nitric oxide. The compounds hg2+ and lactose have been mentioned in the context of this disorder. Affiliated tissues include prostate, myeloid and spinal cord, and related mouse phenotypes are digestive/alimentary and respiratory system.

Disease Ontology:9 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

Aliases & Classifications for Priapism

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 28ICD9CM, 41NCIt, 26ICD10
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Classifications:



Aliases & Descriptions:

priapism 9 44 11 46 63
priapism, familial idiopathic 44 63
familial idiopathic priapism 44
mentulagra 9


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Disease Ontology9 DOID:9286
MeSH36 D011317
ICD9CM28 607.3
NCIt41 C85022
ICD1026 N48.3

Related Diseases for Priapism

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Priapism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease30.9NOS3, HP, G6PD, GLA
2sickle cell anemia30.8HP, G6PD
3hypertension30.1NOS3, PDE5A, F5
4impotence30.1PDE5A, NOS3, NOS2
5hemoglobinopathy30.0G6PD, HP
6hereditary spherocytosis30.0SLC4A1, G6PD
7peyronie's disease29.9PDE5A, NOS2
8thromboembolism29.8F5, G6PD, NOS3
9low-flow priapism10.6
10leukemia10.4
11prostatitis10.3
12adenocarcinoma10.2
13spinal cord injury10.2
14chronic myeloid leukemia10.2
15myeloid leukemia10.2
16prostate cancer10.2
17purpura10.2
18schizophrenia10.2
19protein c deficiency10.1
20thalassemia10.1
21peyronies disease10.1PDE5A
22blood group incompatibility10.1G6PD
23blackwater fever10.1G6PD
24mediterranean spotted fever10.1G6PD
25kernicterus10.1G6PD
26sexual disorder10.1GNRH1, PDE5A
27acute chest syndrome10.1NOS3
28congenital hemolytic anemia10.1G6PD, HP
29favism10.1G6PD, HP
30glucosephosphate dehydrogenase deficiency10.1G6PD, HP
31hemoglobinuria10.1HP, G6PD
32hereditary elliptocytosis10.1SLC4A1, G6PD
33central retinal vein occlusion10.1F5
34placental abruption10.1F5
35factor vii deficiency10.1F5
36autoimmune hemolytic anemia10.1G6PD, HP
37methemoglobinemia10.1G6PD, HP
38paroxysmal nocturnal hemoglobinuria10.1G6PD, HP
39bilirubin metabolic disorder10.1HP, G6PD
40congenital heart disease10.1HP, GLA, PDE5A
41alpha thalassemia10.1G6PD, SLC4A1
42hemolytic anemia10.1G6PD, HP, SLC4A1
43malaria10.1SLC4A1, HP, G6PD
44arteriosclerosis10.1NOS3
45hellp syndrome10.0F5, HP
46primary hyperoxaluria10.0GLA, G6PD, HP
47factor xii deficiency10.0F5, F13A1
48coronary artery disease10.0HP, PDE5A, NOS3
49ovarian hyperstimulation syndrome10.0GNRH1, F5
50dysfibrinogenemia10.0F13A1, F5

Graphical network of the top 20 diseases related to Priapism:



Diseases related to priapism

Symptoms for Priapism

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Drugs & Therapeutics for Priapism

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Priapism

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Search CenterWatch for Priapism

Genetic Tests for Priapism

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Anatomical Context for Priapism

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34MalaCards
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MalaCards organs/tissues related to Priapism:

34
Prostate, Myeloid, Spinal cord, Skin, Smooth muscle, Brain, Kidney, Testes, T cells

Animal Models for Priapism or affiliated genes

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Sources:
38MGI
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Publications for Priapism

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53PubMed
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Articles related to Priapism:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism. (24076963)
2014
2
Priapism Induced by Boceprevir-CYP3A4 Inhibition and I+-Adrenergic Blockade: Case Report. (24092799)
2014
3
18F-FDG PET/CT in a case of malignant priapism secondary to metastasis from mucoid adenocarcinoma of the cecum. (23334147)
2013
4
Unsatisfactory outcomes of prolonged ischemic priapism without early surgical shunts: our clinical experience and a review of the literature. (22922321)
2013
5
Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress. (23844149)
2013
6
Priapism in children: a comprehensive review and clinical guideline. (24135215)
2013
7
High flow priapism on color Doppler ultrasound. (23473902)
2013
8
A pathophysiology-based approach to the management of early priapism. (23202699)
2013
9
Castration for treating recurrent priapism: can we do better? (21799141)
2012
10
Priapism: comorbid factors and treatment outcomes in a contemporary series. (22811705)
2012
11
The use of sudafed for priapism in pediatric patients with sickle cell disease. (22041221)
2012
12
How I manage priapism in chronic myeloid leukaemia patients. (22571386)
2012
13
High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. (19912496)
2011
14
Treating stuttering priapism. (21914108)
2011
15
Early insertion of inflatable prosthesis for intractable ischemic priapism: our experience and review of the literature. (21654814)
2011
16
Daily phosphodiesterase type 5 inhibitor therapy as rescue for recurrent ischemic priapism after failed androgen ablation. (21127306)
2011
17
A crackling priapism related to Fournier's gangrene in a patient on chronic peritoneal dialysis. (20600298)
2010
18
Antipsychotic-induced priapism in an HIV patient: a cytochrome P450-mediated drug interaction. (20606815)
2010
19
Favorable response to intrathecal, but not oral, baclofen of priapism in a patient with spinal cord injury. (19179913)
2009
20
Posttraumatic high-flow priapism: case report, current management options and literature review. (19623873)
2009
21
Ketoconazole and prednisone to prevent recurrent ischemic priapism. (19683289)
2009
22
Investigating the effects of high-dose phenylephrine in the management of prolonged ischaemic priapism. (18466270)
2008
23
Posttraumatic nonischemic priapism treated with autologous blood clot embolization. (18173765)
2008
24
Sickle cell trait and priapism: a case report and review of the literature. (19116025)
2008
25
Glucose-6-phosphate dehydrogenase deficiency associated stuttering priapism: report of a case. (18823322)
2008
26
Sickle cell disease status and outcomes of African-American men presenting with priapism. (18312286)
2008
27
Superselective arterial embolization for patients with high-flow priapism: results of follow-up for five or more years. (17453510)
2007
28
Association between priapism and concurrent use of risperidone and Ginkgo biloba. (17908535)
2007
29
Priapism in the oncology setting. (17441393)
2007
30
The Winter procedure as management for prolonged low-flow priapism: a case report. (18055300)
2007
31
Stuttering priapism after ingestion of alfuzosin. (17070382)
2006
32
High-flow priapism as a complication of a veno-occlusive priapism: two case reports. (16224494)
2006
33
Priapism: new concepts in the pathophysiology and new treatment strategies. (17052448)
2006
34
Is the combination of superselective transcatheter autologous clot embolization and duplex sonography-guided compression therapy useful treatment option for the patients with high-flow priapism? (16079900)
2006
35
Distal cavernosum-glans shunts for ischemic priapism. (16839333)
2006
36
Irreversible priapism during olanzapine and lithium therapy. (15144518)
2004
37
Priapism following ingestion of tamsulosin. (12771780)
2003
38
Priapism secondary to hypertriglyceridemia. (12576856)
2003
39
Evidence-based radiology problems. High-flow post-traumatic priapism: transcatheter embolotherapy: October 2003-September 2004. (14593770)
2003
40
The incidence and management of priapism in Western Australia: a 16 year audit. (12934055)
2003
41
Priapism associated with two atypical antipsychotic agents. (12173794)
2002
42
Management strategy for arterial priapism: therapeutic dilemmas. (12394712)
2002
43
Interventional treatment of traumatic priapism. (12431145)
2002
44
The management of low-flow priapism with the immediate insertion of a penile prosthesis. (12460352)
2002
45
Unusual complications of warfarin therapy: skin necrosis and priapism. (10931425)
2000
46
Re: Chronic myeloid leukaemia presenting as priapism in children: need for multidisciplinary approach. (12862132)
2000
47
Priapism in a patient with protein C deficiency. (9352148)
1997
48
Permanent open shunt as a reason for impotence or reduced potency after surgical treatment of priapism in 26 patients. (8750051)
1995
49
Priapism associated with chronic cocaine abuse. (8042894)
1994
50
Priapism associated with intranasal cocaine abuse. (2304177)
1990

Variations for Priapism

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Expression for genes affiliated with Priapism

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for genes affiliated with Priapism

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 5Cell Signaling Technology, 62Tocris Bioscience, 61Thomson Reuters, 54QIAGEN, 31KEGG
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Pathways related to Priapism according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9AQP1, SLC4A1
2
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis39
9.5NOS3, NOS2
39.5NOS3, NOS2
4
Show member pathways
9.5NOS3, NOS2
59.1TGFBR3, ITGAV, NOS3
6
Show member pathways
9.1NOS3, ITGAV, TGFBR3
7
Show member pathways
8.9NOS3, NOS2, PDE5A
88.9NOS3, NOS2, PDE5A
9
Show member pathways
8.9PDE5A, NOS2, NOS3
10
Show member pathways
8.7NOS3, ITGAV, TGFBR3, GNRH1
118.7ADORA2B, NOS2, NOS3
12
Show member pathways
Development EDNRB signaling61
Development ACM2 and ACM4 activation of ERK61
Cell adhesion Integrin inside out signaling61
Development G Proteins mediated regulation MARK ERK signaling61
Signal transduction IP3 signaling61
Development Angiotensin signaling via PYK261
Development EPO induced MAPK pathway61
8.6ADORA2B, ITGAV, NOS3
13
Show member pathways
8.2AQP1, G6PD, KL, GLA, NOS2, NOS3
14
Show member pathways
7.6NOS3, F13A1, ITGAV, PDE5A, F5, NOS2

Compounds for genes affiliated with Priapism

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 25HMDB, 52PharmGKB, 30IUPHAR
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Compounds related to Priapism according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1hg2+4610.3AQP1, GLA
2lactose46 1210.9HP, GLA, G6PD
3magnesium lithospermate b469.9NOS2, NOS3
4l-thiocitrulline46 1210.9NOS2, NOS3
5s-ethylisothiourea46 1210.9NOS2, NOS3
6n5-(1-iminoethyl)-l-ornithine469.8NOS2, NOS3
7nitrit469.8NOS2, NOS3
8n-(3-(aminomethyl)benzyl)acetamidine46 1210.8NOS2, NOS3
9n(g)-hydroxy-l-arginine469.8NOS3, NOS2
103-bromo-7-nitroindazole62 1210.8NOS2, NOS3
117-nitroindazole46 1210.8NOS3, NOS2
12kininogen469.7F13A1, HP, F5
13vitamin b12469.6HP, G6PD, F5
14malondialdehyde469.6F5, G6PD, HP
15urea46 25 1211.6F5, HP, AQP1, F13A1
16glycerol46 25 1211.6G6PD, NOS3, AQP1, GLA
17raloxifene46 52 30 1212.5NOS3, GNRH1, F5
18pentoxifylline46 1210.5GNRH1, HP, PDE5A
19diphenyleneiodonium469.5NOS2, G6PD, NOS3
20phospholipid469.4F5, GLA, AQP1, SLC4A1, HP
21epinephrine46 25 1211.4GNRH1, G6PD, F5, HP
22n(g),n(g)-dimethylarginine469.4NOS3, NOS2
23aspartate469.3F5, G6PD, HP, GLA, GNRH1
24vitamin-e469.3G6PD, PDE5A, F5, HP
25kt 582346 3010.3PDE5A, NOS2, NOS3
26sildenafil30 46 52 25 1213.3NOS3, PDE5A, NOS2
27nitroglycerin46 1210.2NOS3, PDE5A, NOS2
28peroxynitrite469.2SLC4A1, NOS2, NOS3
29nitrate469.2PDE5A, NOS3, NOS2
30citrate469.1SLC4A1, NOS3, F5, HP, G6PD
31creatinine469.1GLA, F5, HP, G6PD, GNRH1, AQP1
32lactate469.1GLA, F5, HP, G6PD, GNRH1, SLC4A1
33aspirin46 52 30 2512.1HP, F13A1, G6PD, NOS3, F5
34cgmp46 3010.0NOS2, NOS3, AQP1, PDE5A
35actinomycin d469.0NOS2, NOS3, GNRH1, HP, G6PD
36tamoxifen46 52 30 1212.0F5, GNRH1, G6PD, NOS3
37ascorbic acid46 259.9NOS3, NOS2, F5, G6PD, HP
38prostacyclin468.9NOS3, F5, PDE5A, NOS2
39testosterone46 62 25 1211.7GNRH1, G6PD, HP, PDE5A, F5
40fibrinogen468.6ITGAV, F5, HP, F13A1
41adenylate468.6NOS2, HP, ADORA2B, GNRH1, G6PD
42pge1468.6F5, PDE5A, ADORA2B
43folate468.5PDE5A, G6PD, SLC4A1, NOS3, HP, F5
44sodium nitroprusside468.4GNRH1, AQP1, PDE5A, NOS2, NOS3, G6PD
45arginine468.1GNRH1, NOS3, NOS2, GLA, PDE5A, F5
46nitric oxide46 25 129.9GLA, NOS2, NOS3, PDE5A, HP, AQP1
47estrogen467.7NOS2, F5, PDE5A, HP, G6PD, F13A1
48glutamate467.6NOS2, NOS3, SLC4A1, F5, HP, ADORA2B
49vegf467.3NOS3, F13A1, AQP1, ITGAV, HP, PDE5A
50calcium46 52 25 129.2AQP1, F13A1, ADORA2B, ITGAV, NOS3, NOS2

GO Terms for genes affiliated with Priapism

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17Gene Ontology
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Cellular components related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cortical cytoskeletonGO:0308639.7SLC4A1, NOS2
2blood microparticleGO:0725629.5SLC4A1, HP, F13A1
3extracellular regionGO:0055768.7F13A1, GNRH1, HP, F5, KL, GLA
4extracellular spaceGO:0056158.6GNRH1, TGFBR3, HP, F5, KL
5extracellular vesicular exosomeGO:0700628.3SLC4A1, TGFBR3, AQP1, G6PD, ITGAV, HP
6integral component of plasma membraneGO:0058878.0TGFBR3, AQP1, ADORA2B, ITGAV, KL, SLC4A1

Biological processes related to Priapism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1bicarbonate transportGO:0157019.8SLC4A1, AQP1
2arginine catabolic processGO:0065279.7NOS3, NOS2
3nitric oxide biosynthetic processGO:0068099.6NOS3, NOS2
4nitric oxide mediated signal transductionGO:0072639.6NOS2, NOS3
5negative regulation of blood pressureGO:0457769.6NOS3, NOS2
6positive regulation of vasodilationGO:0459099.5NOS3, NOS2
7interaction with hostGO:0517019.2NOS2, NOS3
8positive regulation of guanylate cyclase activityGO:0312848.9NOS3, NOS2, ADORA2B
9small molecule metabolic processGO:0442818.9SLC4A1, NOS3, GLA, G6PD, AQP1
10blood coagulationGO:0075967.8F13A1, ITGAV, PDE5A, F5, NOS2, NOS3

Molecular functions related to Priapism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:0045179.7NOS3, NOS2
2arginine bindingGO:0346189.7NOS2, NOS3
3tetrahydrobiopterin bindingGO:0346179.6NOS2, NOS3
4NADPH-hemoprotein reductase activityGO:0039589.6NOS3, NOS2
5transforming growth factor beta bindingGO:0504319.6TGFBR3, ITGAV
6fibroblast growth factor bindingGO:0171349.6KL, TGFBR3
7NADP bindingGO:0506619.4NOS3, NOS2, G6PD
8FMN bindingGO:0101819.4NOS2, NOS3
9protein homodimerization activityGO:0428039.2SLC4A1, NOS2, GLA, G6PD
10protein bindingGO:0055156.9TGFBR3, AQP1, G6PD, ITGAV, HP, F5

Products for genes affiliated with Priapism

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Sources for Priapism

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet