MCID: PRP007
MIFTS: 47

Priapism malady

Categories: Genetic diseases, Rare diseases, Reproductive diseases, Cardiovascular diseases

Aliases & Classifications for Priapism

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Aliases & Descriptions for Priapism:

Name: Priapism 11 48 50 39 13 68
Priapism, Familial Idiopathic 48 68
 
Familial Idiopathic Priapism 48
Mentulagra 11

Classifications:



External Ids:

Disease Ontology11 DOID:9286
ICD1030 N48.3, N48.30
ICD9CM32 607.3
MeSH39 D011317
NCIt45 C85022

Summaries for Priapism

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Wikipedia:71 Priapism is a medical condition in which the erect penis does not return to its flaccid state, despite... more...

MalaCards based summary: Priapism, also known as priapism, familial idiopathic, is related to low-flow priapism and embryoma, and has symptoms including painful penile erection, painful ejaculation and sexual function symptom/complaint male. An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways are Nitric oxide stimulates guanylate cyclase and NO-dependent CFTR activation (normal and CF). Affiliated tissues include myeloid, prostate and spinal cord, and related mouse phenotypes are muscle and renal/urinary system.

Disease Ontology:11 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

Related Diseases for Priapism

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Graphical network of the top 20 diseases related to Priapism:



Diseases related to priapism

Symptoms & Phenotypes for Priapism

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UMLS symptoms related to Priapism:


painful penile erection, painful ejaculation, sexual function symptom/complaint male, (priapism) or (erection - painful)

MGI Mouse Phenotypes related to Priapism according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.9ITGAV, KL, NOS3, SLC4A1, TGFBR3
2MP:00053678.5AQP1, ITGAV, KL, NOS3, SLC4A1
3MP:00053898.1AQP1, F13A1, KL, NOS3, TGFBR3
4MP:00053977.8AQP1, F13A1, ITGAV, KL, NOS3, SLC4A1
5MP:00053767.7AQP1, F13A1, F5, ITGAV, KL, NOS3
6MP:00053857.2AQP1, F13A1, F5, ITGAV, KL, NOS3
7MP:00107687.2AQP1, F13A1, F5, ITGAV, KL, NOS3

Drugs & Therapeutics for Priapism

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Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PrazosinapprovedPhase 36219216-56-94893
Synonyms:
1-(3-Amino-6,7-dimethoxy-2- quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) piperazine
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine
19216-56-9
2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline
2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone
5-25-13-00365 (Beilstein Handbook Reference)
AB00053528
AC1L1J6T
AKOS000310009
BCBcMAP01_000227
BPBio1_001006
BRD-K49111258-001-02-8
BRD-K49111258-003-05-7
BRN 0768345
BSPBio_000914
BSPBio_001036
BSPBio_002221
Bio1_000365
Bio1_000854
Bio1_001343
Bio2_000358
Bio2_000838
C07368
C19H21N5O4
CAS-19237-84-4
CHEBI:8364
CHEMBL2
CID4893
CP-12299
D08411
DB00457
DivK1c_000375
EINECS 242-885-8
Furazosin
HMS1362D17
HMS1792D17
HMS1990D17
HMS2089G09
HSDB 3298
IDI1_000375
IDI1_002113
Justac
KBio1_000375
KBio2_000376
KBio2_001302
KBio2_002944
KBio2_003870
KBio2_005512
KBio2_006438
KBio3_000731
KBio3_000732
KBio3_001721
KBioGR_000376
KBioGR_000965
KBioSS_000376
KBioSS_001302
 
L000666
LS-140002
Lentopres
Minipress
Minipress (TN)
Minipress Xl
MolPort-000-891-036
NCGC00016740-01
NCGC00016740-02
NCGC00016740-03
NCGC00016740-14
NCGC00024324-02
NCGC00024324-04
NCGC00024324-05
NCGC00024324-06
NCGC00024324-07
NCGC00024324-08
NCGC00024324-09
NCI60_002417
NINDS_000375
Oprea1_314778
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- (9CI)
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- (8CI)
Prazocin
Prazosin (INN)
Prazosin HCl
Prazosin Hydrochloride
Prazosin [INN:BAN]
Prazosina
Prazosina [INN-Spanish]
Prazosine
Prazosine [INN-French]
Prazosinum
Prazosinum [INN-Latin]
Prestwick0_000947
Prestwick1_000947
Prestwick2_000947
Prestwick3_000947
SMP1_000063
SPBio_001297
SPBio_003073
ST075549
STK301545
Spectrum2_001289
Spectrum3_000551
Spectrum4_000483
Spectrum5_001365
Spectrum_000822
TL8001573
TNP00312
Tocris-0623
UNII-XM03YJ541D
Vasoflex
ZINC00601304
[3H]-Prazosin
[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
prazosin
2Neurotransmitter AgentsPhase 317734
3Adrenergic AgentsPhase 35140
4Adrenergic AntagonistsPhase 31535
5Adrenergic alpha-1 Receptor AntagonistsPhase 3470
6Adrenergic alpha-AntagonistsPhase 3727
7Antihypertensive AgentsPhase 34095
8
HydroxyureaapprovedPhase 2215127-07-13657
Synonyms:
1-HYDROXYUREA
127-07-1
4-03-00-00170 (Beilstein Handbook Reference)
55291_FLUKA
AC1L1GF8
AC1Q4ZXK
AI3-51139
BB_SC-7256
BRN 1741548
BSPBio_002164
Bio1_000451
Bio1_000940
Bio1_001429
Biosupressin
C07044
CCRIS 958
CHEBI:44423
CHEMBL467
CID3657
Carbamohydroxamic Acid
Carbamohydroxamic acid
Carbamohydroximic Acid
Carbamohydroximic acid
Carbamohydroxyamic Acid
Carbamohydroxyamic acid
Carbamoyl Oxime
Carbamoyl oxime
Carbamyl Hydroxamate
Carbamyl hydroxamate
Carrbamoyl Oxime
D00341
D006918
DB01005
DRG-0253
DivK1c_000556
Droxia
Droxia (TM)
Droxia (TN)
E0723DBA-5AF3-49D1-B5F6-59420AB87AC9
EINECS 204-821-7
EU-0100596
FT-0083575
H 8627
H0310
H20210
H8627_SIGMA
HMS1920F09
HMS2091L17
HMS501L18
HSDB 6887
HU
HYDREA (TN)
HYDROXY-UREA
Hidrix
Hidroxicarbamida
Hidroxicarbamida [INN-Spanish]
Hydrea
Hydrea (TM)
Hydrea, Biosupressin, Cytodrox, Hydroxyurea
Hydreia
Hydroxicarbamidum
Hydroxycarbamid
Hydroxycarbamide
Hydroxycarbamide (JAN/INN)
Hydroxycarbamidum
Hydroxycarbamidum [INN-Latin]
Hydroxycarbamine
Hydroxyharnstoff
Hydroxyharnstoff [German]
Hydroxylurea
Hydroxyurea
Hydroxyurea (D4)
Hydroxyurea (USP)
Hydroxyurea [USAN:BAN]
Hydroxyurea(d4)
 
Hydura
Hydurea
I05-0250
IDI1_000556
Idrossicarbamide
Idrossicarbamide [DCIT]
Idrossicarbamide [Dcit]
KBio1_000556
KBio2_001389
KBio2_003957
KBio2_006525
KBio3_001384
KBioGR_000383
KBioSS_001389
LS-709
Litaler
Litalir
Lopac-H-8627
Lopac0_000596
MLS001332381
MLS001332382
MLS002153389
MolMap_000029
MolPort-000-003-971
Mylocel
N-(Aminocarbonyl) Hydroxyamine
N-Carbamoylhydroxylamine
N-HYDROXY UREA
N-Hydroxymocovina
N-Hydroxymocovina [Czech]
N-Hydroxyurea
NCGC00015520-01
NCGC00015520-02
NCGC00015520-07
NCGC00093974-01
NCGC00093974-02
NCGC00093974-03
NCGC00093974-04
NCGC00093974-05
NCI C04831
NCI-C04831
NCI60_002773
NCIMech_000139
NHY
NINDS_000556
NSC 32065
NSC32065
Onco-Carbide
Onco-carbide
Oncocarbide
Oxyurea
S-phase/G-1 interface inhibitor
S1896_Selleck
SK 22591
SMR000059149
SPBio_000247
SPECTRUM1500344
SQ 1089
SQ-1089
Siklos
Spectrum2_000064
Spectrum3_000462
Spectrum4_000012
Spectrum5_000836
Spectrum_000909
Sterile Urea
TL8000673
UNII-X6Q56QN5QC
Ureaphil
WLN: ZVMQ
carbamide oxide
hydroxyaminomethanamide
hydroxyurea
nchembio.573-comp3
nchembio.90-comp4
nchembio749-comp3
tetratogen: inhibits ribonucleoside diphosphate reductase
9Antibodies, MonoclonalPhase 23795
10ImmunoglobulinsPhase 26045
11Nucleic Acid Synthesis InhibitorsPhase 24855
12AntibodiesPhase 26045
13Phosphodiesterase InhibitorsPhase 21254
14Phosphodiesterase 5 InhibitorsPhase 2571
15Sildenafil CitratePhase 2323171599-83-0
16Vasodilator AgentsPhase 23438
17
Citric Acidnutraceutical, vet_approvedPhase 2110677-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
18CitrateNutraceuticalPhase 21106
19
Tamsulosinapproved, investigational157106133-20-4129211
Synonyms:
(R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide
106133-20-4
5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide
5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide
5-[2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide
5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide
5-{(2R)-2-[(2-{[2-(ethyloxy)phenyl]oxy}ethyl)amino]propyl}-2-(methyloxy)benzenesulfonamide
AC1L2V76
BIDD:GT0261
C07124
C20H28N2O5S
CHEBI:9398
CHEMBL836
CID129211
D08560
DB00706
FT-0082894
Flomax
Flomax (TN)
 
Flowmax
HMS2090P15
Harnal
LS-31578
MolPort-003-850-388
NCGC00167442-01
STK626950
TAMSULOSIN
Tamsolusin
Tamsulon
Tamsulon (TN)
Tamsulosin
Tamsulosin (INN)
Tamsulosin [INN:BAN]
Tamsulosina
Tamsulosina [INN-Spanish]
Tamsulosine
Tamsulosine [INN-French]
Tamsulosinum
Tamsulosinum [INN-Latin]
UNII-G3P28OML5I
YM-617
20
Silodosinapproved22160970-54-7
Synonyms:
KAD 3213
 
KMD 3213
Rapaflo
Urief

Interventional clinical trials:

idNameStatusNCT IDPhase
1AScVS and/ or Prazosin for Scorpion EnvenomationCompletedNCT00753064Phase 3
2Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain CrisesCompletedNCT01895361Phase 2
3Sildenafil for Treatment of Priapism in Men With Sickle Cell AnemiaTerminatedNCT00940901Phase 2
4Tadalafil for Treatment of Priapism in Men With Sickle Cell AnemiaWithdrawnNCT00538564Phase 2
5Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave LithotripsyUnknown statusNCT01560091
6Priapism in Boys and Men With Sickle Cell Disease - Demographics, Characteristics and PrevalenceCompletedNCT00300235
7Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal EventsRecruitingNCT02539771
8Androgen Regulation of Priapism in Sickle Cell DiseaseWithdrawnNCT01940718Early Phase 1

Search NIH Clinical Center for Priapism


Cochrane evidence based reviews: priapism

Genetic Tests for Priapism

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Anatomical Context for Priapism

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MalaCards organs/tissues related to Priapism:

36
Myeloid, Prostate, Spinal cord, Brain, Skin, Smooth muscle, Tongue

Publications for Priapism

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Articles related to Priapism:

(show top 50)    (show all 618)
idTitleAuthorsYear
1
Emergency Department Management Of Priapism. (28027457)
2017
2
Priapism in the Newborn: Shall We Intervene? (28083497)
2017
3
Guideline of guidelines: priapism. (27860090)
2017
4
Correction: Emergency Department Visits and Inpatient Admissions Associated with Priapism among Males with Sickle Cell Disease in the United States, 2006-2010. (27557148)
2016
5
al-Ghorab Shunt for Priapism. (27436080)
2016
6
Risk Factors for Priapism Readmission. (27496074)
2016
7
Poster 321 Trazodone Associated Clitoral Priapism in a Transgender Man following Traumatic Brain Injury: A Case Report. (27673077)
2016
8
Beneficial effect of the nitric oxide donor compound 3-(1,3-dioxoisoindolin-2-yl)benzyl nitrate on dysregulated phosphodiesterase 5, NADPH oxidase and nitrosative stress in the sickle cell mouse penis: implication for priapism treatment. (27540002)
2016
9
Clinical Management of Priapism: A Review. (27169123)
2016
10
Embolization Treatment of High-Flow Priapism. (27582604)
2016
11
Priapism and glucose-6-phosphate dehydrogenase deficiency: An underestimated correlation? (27711102)
2016
12
Priapism as the Presenting Complaint in Fatal Group A Streptococcal Induced Disseminated Intravascular Coagulation. (27989251)
2016
13
Priapism and Hypersexuality Associated With Rotigotine in an Elderly Parkinsonian Patient: A Case Report. (27046660)
2016
14
Use of amisulpride in treating adolescent onset schizophrenia associated with stuttering priapism induced by multiple antipsychotics. (26957345)
2016
15
Emergency Department Visits and Inpatient Admissions Associated with Priapism among Males with Sickle Cell Disease in the United States, 2006-2010. (27078839)
2016
16
Steroids, drugs and stuttering priapism; the rock-and-roll lifestyle of a 24-year-old man. (26822610)
2016
17
Intracavernosal metaraminol bitartrate for treatment of priapism resulting from circumcision: a case report. (27104124)
2016
18
Malignant priapism due to penile metastases: Case series and literature review. (27377094)
2016
19
Priapism - A Rare Presentation in Chronic Myeloid Leukemia: CaseA Report. (26793565)
2016
20
The possible protective effects of dipyridamole on ischemic reperfusion injury of priapism. (27136481)
2016
21
T-Shaped Shunt with Intracavernosal Tunneling, for a Pediatric Case of Refractory Ischemic Priapism. (27693479)
2016
22
High Flow Priapism in a Pediatric Patient after Circumcision with Dorsal Penile Nerve Block. (27648333)
2016
23
Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength. (27145183)
2016
24
Ischemic priapism in South-East Nigeria: Presentation, management challenges, and aftermath issues. (26856282)
2016
25
Percutaneous Direct Puncture Embolization with N-butyl-cyanoacrylate for High-flow Priapism. (27164971)
2016
26
Recurring priapism may be a symptom of voiding dysfunction - case report and literature review. (27256196)
2016
27
Risperidone-induced priapism in an autistic child: a case report. (27266696)
2016
28
Surgical Management of Stuttering Ischemic Priapism: A Case Report and Concise Clinical Review. (26977408)
2016
29
Outcome and erectile function following treatment of priapism: An institutional experience. (26834401)
2016
30
Priapism as a new symptom of anaphylaxis in a prepubescent child. (27496320)
2016
31
Noninvasive treatments for iatrogenic priapism: Do they really work? A prospective multicenter study. (27141191)
2016
32
A case of carbamazepine-induced priapism. (27285395)
2016
33
Homocysteinemia: A rare cause of priapism. (26834419)
2016
34
Study of priapism as a side effect of heparin therapy in deep venous thrombosis. (27728751)
2016
35
Use of High-Dose Phenylephrine in the Treatment of Ischemic Priapism: Five-Year Experience at a Single Institution. (27692841)
2016
36
Regular automated red cell exchange transfusion in the management of stuttering priapism complicating sickle cell disease. (27723091)
2016
37
Does platelet activity play a role in the pathogenesis of idiopathic ischemic priapism? (27136477)
2016
38
Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? (27408418)
2016
39
Nonischaemic priapism associated with selective serotonin-3 receptor antagonist. (27709642)
2016
40
Ethylene-vinyl alcohol copolymer (Onyx(Ar)) transarterial embolization for post-traumatic high-flow priapism. (27429919)
2016
41
Penile Priapism, Clitoral Priapism, and Persistent Genital Arousal Disorder: A Contemporary Review. (27784607)
2015
42
Priapism in Homozygous Sickle Cell Disease: A 40-year Study of the Natural History. (26426165)
2015
43
Risperidone, quetiapine and chlorpromazine may have induced priapism in an adolescent. (26542690)
2015
44
Safety and efficacy of blood exchange transfusion for priapism complicating sickle cell disease. (25809639)
2015
45
Modified technique in treating recurrent priapism: a technique report. (25578936)
2015
46
Chronic myeloid leukemia presented with priapism: Effective management with prompt leukapheresis. (26289527)
2015
47
Partial Priapism Treated with Pentoxifylline. (26401875)
2015
48
Subacute Hemolysis in Sickle Cell Mice Causes Priapism Secondary to NO Imbalance and PDE5 Dysregulation. (26346631)
2015
49
Delayed-onset of psychopharmacologically induced priapism: A cautionary case report. (26188724)
2015
50
Re: Safety and Efficacy of Blood Exchange Transfusion for Priapism Complicating Sickle Cell Disease. (26478057)
2015

Variations for Priapism

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Expression for genes affiliated with Priapism

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Search GEO for disease gene expression data for Priapism.

Pathways for genes affiliated with Priapism

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Pathways related to Priapism according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8NOS3, PDE5A
29.8NOS3, PDE5A
3
Show member pathways
9.2ITGAV, NOS3, TGFBR3
4
Show member pathways
9.2ITGAV, NOS3, TGFBR3

GO Terms for genes affiliated with Priapism

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Cellular components related to Priapism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.5F13A1, F5
2integral component of plasma membraneGO:00058878.1AQP1, ITGAV, KL, SLC4A1, TGFBR3

Biological processes related to Priapism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell growthGO:00160499.5ITGAV, TGFBR3
2bicarbonate transportGO:00157019.5AQP1, SLC4A1

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:00150269.9ITGAV, TGFBR3
2transforming growth factor beta bindingGO:00504319.5ITGAV, TGFBR3
3fibroblast growth factor bindingGO:00171349.4ITGAV, KL, TGFBR3

Sources for Priapism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet