MCID: PRP007
MIFTS: 49

Priapism

Categories: Rare diseases, Reproductive diseases, Genetic diseases, Cardiovascular diseases

Aliases & Classifications for Priapism

MalaCards integrated aliases for Priapism:

Name: Priapism 12 49 51 41 14 69
Priapism, Familial Idiopathic 49 69
Familial Idiopathic Priapism 49
Mentulagra 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9286
ICD10 32 N48.3 N48.30
ICD9CM 34 607.3
MeSH 41 D011317
NCIt 46 C85022

Summaries for Priapism

Disease Ontology : 12 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

MalaCards based summary : Priapism, also known as priapism, familial idiopathic, is related to thrombophilia due to thrombin defect and vasculogenic impotence, and has symptoms including painful erection An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Apoptosis Pathway. The drugs Prazosin and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include myeloid, prostate and spinal cord, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Wikipedia : 72 Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after... more...

Related Diseases for Priapism

Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 thrombophilia due to thrombin defect 29.9 F13A1 F5
2 vasculogenic impotence 29.8 NOS3 PDE5A
3 impotence 29.7 NOS3 PDE5A
4 homocysteinemia 29.5 F5 NOS3
5 intracranial hypertension 29.4 AQP1 F5
6 autosomal dominant polycystic kidney disease 29.1 AQP1 KL NOS3
7 low-flow priapism 12.2
8 priapism, familial idiopathic 11.9
9 persistent genital arousal disorder 11.3
10 sickle cell disease 10.3
11 stuttering 10.3
12 persistent fetal circulation syndrome 10.3 NOS3 PDE5A
13 sexual disorder 10.3 NOS3 PDE5A
14 carotid artery occlusion 10.3 F5 NOS3
15 factor xiii deficiency 10.2 F13A1 F5
16 dysfibrinogenemia 10.2 F13A1 F5
17 leukemia 10.1
18 sickle cell anemia 10.1
19 arteritic anterior ischemic optic neuropathy 10.1 F5 NOS3 PDE5A
20 ischemic optic neuropathy 10.1 F5 NOS3 PDE5A
21 nonarteritic anterior ischemic optic neuropathy 10.1 F5 NOS3 PDE5A
22 prostatitis 10.1
23 leukemia, chronic myeloid 10.0
24 myeloid leukemia 10.0
25 dysferlinopathy 10.0 AQP1 MIP
26 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.0
27 spinal cord injury 10.0
28 thrombosis 10.0
29 adenocarcinoma 10.0
30 schizophrenia 9.9
31 thalassemia 9.9
32 meniere disease 9.9 AQP1 MIP
33 diabetes insipidus, nephrogenic, autosomal 9.9 AQP1 MIP
34 fibrosis of extraocular muscles, congenital, 1 9.9
35 prostate cancer 9.9
36 purpura 9.9
37 varicocele 9.8 GNRH1 NOS3
38 fabry disease 9.8
39 suppression of tumorigenicity 12 9.8
40 episodic pain syndrome, familial, 1 9.8
41 protein c deficiency 9.8
42 ovarian hyperstimulation syndrome 9.8 F5 GNRH1
43 patent foramen ovale 9.8 F13A1 F5
44 myocardial infarction 9.8 F13A1 F5 NOS3 PDE5A
45 autism 9.7
46 myeloma, multiple 9.7
47 anxiety 9.7
48 beta-thalassemia 9.7
49 lymphoma 9.7
50 protein s deficiency 9.7

Graphical network of the top 20 diseases related to Priapism:



Diseases related to Priapism

Symptoms & Phenotypes for Priapism

UMLS symptoms related to Priapism:


painful erection

MGI Mouse Phenotypes related to Priapism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 AQP1 F13A1 F5 ITGAV KL NOS3
2 endocrine/exocrine gland MP:0005379 9.8 AQP1 F13A1 GNRH1 ITGAV KL NOS3
3 hematopoietic system MP:0005397 9.8 AQP1 F13A1 GNRH1 ITGAV KL NOS3
4 liver/biliary system MP:0005370 9.55 NOS3 TGFBR3 F5 GNRH1 KL
5 renal/urinary system MP:0005367 9.35 AQP1 GNRH1 ITGAV KL NOS3
6 reproductive system MP:0005389 9.1 AQP1 F13A1 GNRH1 KL NOS3 TGFBR3

Drugs & Therapeutics for Priapism

Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prazosin Approved Phase 3 19216-56-9 4893
2 Adrenergic Agents Phase 3
3 Adrenergic alpha-1 Receptor Antagonists Phase 3
4 Adrenergic alpha-Antagonists Phase 3
5 Adrenergic Antagonists Phase 3
6 Neurotransmitter Agents Phase 3
7 Antihypertensive Agents Phase 3
8
Hydroxyurea Approved Phase 2 127-07-1 3657
9
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
10 Sildenafil Citrate Phase 2 171599-83-0
11 Vasodilator Agents Phase 2
12 Nucleic Acid Synthesis Inhibitors Phase 2
13 Antibodies, Monoclonal Phase 2
14 Phosphodiesterase 5 Inhibitors Phase 2
15 Phosphodiesterase Inhibitors Phase 2
16 Immunoglobulins Phase 2
17 Antibodies Phase 2
18 Citrate Nutraceutical Phase 2

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 AScVS and/ or Prazosin for Scorpion Envenomation Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
2 Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy Withdrawn NCT01560091 Phase 3 silodosin;Tamsulosin
3 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed NCT00940901 Phase 2 sildenafil
4 Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises Completed NCT01895361 Phase 2 SelG1;Placebo
5 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Adult Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Recruiting NCT03264989 Phase 2 crizanlizumab
6 Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia Withdrawn NCT00538564 Phase 2 tadalafil;placebo
7 Priapism in Boys and Men With Sickle Cell Disease - Demographics, Characteristics and Prevalence Completed NCT00300235
8 Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events Recruiting NCT02539771
9 Substudy of CADRE: for People With Extreme Phenotype: BIOCADRE Recruiting NCT03352986
10 Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose Recruiting NCT03114137
11 Androgen Regulation of Priapism in Sickle Cell Disease Withdrawn NCT01940718 Early Phase 1 Transdermal Androgel

Search NIH Clinical Center for Priapism

Cochrane evidence based reviews: priapism

Genetic Tests for Priapism

Anatomical Context for Priapism

MalaCards organs/tissues related to Priapism:

38
Myeloid, Prostate, Spinal Cord, Heart, Brain, Skin, Smooth Muscle

Publications for Priapism

Articles related to Priapism:

(show top 50) (show all 659)
# Title Authors Year
1
Recent advances in the management of priapism. ( 29375820 )
2018
2
BAUS Consensus Document for the Management of Male Genital Emergencies - Priapism. ( 29357203 )
2018
3
Molecular Profile of Priapism Associated with Low Nitric Oxide Bioavailability. ( 29394072 )
2018
4
Penile Metastasis from Prostate Cancer Presenting as Malignant Priapism Detected Using Gallium-68 Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography. ( 29430118 )
2018
5
Superselective Transcatheter Artery Embolization in Patients with Non-ischemic Priapism. ( 29417263 )
2018
6
Priapism as the initial sign in hematologic disease: Case report and literature review. ( 29414500 )
2018
7
Through Clinical Observation: The History of Priapism After Spinal Cord Injuries. ( 29054772 )
2018
8
Role of Penile Prosthesis in Priapism: A Review. ( 29299902 )
2018
9
Case - Temporary chemical castration in the management of recurrent priapism. ( 29405906 )
2018
10
Prognosis of men with penile metastasis and malignant priapism: a systematic review. ( 29416825 )
2018
11
Priapism ( 29083574 )
2017
12
Guideline of guidelines: priapism. ( 27860090 )
2017
13
Recurrent Priapism in a Military Veteran Receiving Treatment for PTSD. ( 29087891 )
2017
14
Is there a relation between priapism occurring after penile doppler ultrasonography and international erectile function index score and erection hardness score levels? ( 29201505 )
2017
15
Advances in the understanding of priapism. ( 28540227 )
2017
16
Priapism Associated With Antipsychotic Medication Use: Case Report. ( 28590368 )
2017
17
Hallucination and priapism associated with methylphenidate usage: Two case reports. ( 29085103 )
2017
18
Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression. ( 29110178 )
2017
19
Priapism associated with the addition of risperidone to methylphenidate monotherapy: a case report. ( 28752150 )
2017
20
Penile Prosthesis Implantation in Priapism. ( 28916463 )
2017
21
Contemporary best practice in the evaluation and management of stuttering priapism. ( 28932276 )
2017
22
The Semantics of Priapism and the First Sign of Chronic Myeloid Leukemia. ( 28638667 )
2017
23
Prognostic Factors and Outcome of Management of Ischemic Priapism in Zaria, Nigeria. ( 28584506 )
2017
24
Emergency department management of priapism [digest]. ( 28745844 )
2017
25
Priapism with penile gangrene: An unusual presentation of multiple myeloma. ( 28717280 )
2017
26
Case report: ischemic priapism secondary to tinzaparin. ( 29222429 )
2017
27
Priapism in the Newborn: Shall We Intervene? ( 28083497 )
2017
28
Postoperative drug-induced priapism. ( 28566410 )
2017
29
Management in Neonatal Priapism: Case and Review. ( 28752068 )
2017
30
The use of penile prostheses in the management of priapism. ( 29238659 )
2017
31
Ultrasound-guided penile nerve block in pediatrics: An answer to intraoperative priapism. ( 28757858 )
2017
32
Conversion of Low-Flow Priapism to High-Flow State Using T-Shunt with Tunneling. ( 28331646 )
2017
33
Ischemic priapism: Can eosinophil count and platelet functions be positive predictive factors in etiopathogenesis. ( 28761591 )
2017
34
Thalassemia Major and Priapism: A Case Report of an Adolescent. ( 28538505 )
2017
35
Effect of lysyl oxidase (LOX) on corpus cavernous fibrosis caused by ischaemic priapism. ( 29278308 )
2017
36
Management of refractory ischemic priapism: current perspectives. ( 28920056 )
2017
37
Treatments for priapism in boys and men with sickle cell disease. ( 28926088 )
2017
38
The management of the acute ischemic priapism: A state of the art review. ( 28528136 )
2017
39
Avoiding complications: surgery for ischemic priapism. ( 28904898 )
2017
40
Challenges surrounding penile prostheses insertion following acute priapism. ( 29239397 )
2017
41
Priapism due to essential thrombocythaemia: a rare causation. ( 28824001 )
2017
42
Leech Therapy for Treating Priapism: Case Report. ( 28845411 )
2017
43
Emergency Department Management Of Priapism. ( 28027457 )
2017
44
Noninvasive treatments for iatrogenic priapism: Do they really work? A prospective multicenter study. ( 27141191 )
2016
45
Clinical Management of Priapism: A Review. ( 27169123 )
2016
46
Study of priapism as a side effect of heparin therapy in deep venous thrombosis. ( 27728751 )
2016
47
Priapism as the Presenting Complaint in Fatal Group A Streptococcal Induced Disseminated Intravascular Coagulation. ( 27989251 )
2016
48
Risk Factors for Priapism Readmission. ( 27496074 )
2016
49
al-Ghorab Shunt for Priapism. ( 27436080 )
2016
50
Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? ( 27408418 )
2016

Variations for Priapism

Expression for Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for Priapism

Pathways related to Priapism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 F13A1 F5 ITGAV NOS3 PDE5A
2
Show member pathways
11.92 ITGAV NOS3 TGFBR3
3
Show member pathways
10.88 NOS3 PDE5A
4 10.74 ITGAV NOS3 TGFBR3
5 10.07 NOS3 PDE5A

GO Terms for Priapism

Cellular components related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.13 AQP1 KL MIP
2 integral component of plasma membrane GO:0005887 9.02 AQP1 ITGAV KL MIP TGFBR3

Biological processes related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemostasis GO:0007599 9.26 F13A1 F5
2 positive regulation of cell adhesion GO:0045785 9.16 ITGAV MIP
3 water transport GO:0006833 8.96 AQP1 MIP
4 response to prostaglandin E GO:0034695 8.62 GNRH1 TGFBR3

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.32 ITGAV TGFBR3
2 channel activity GO:0015267 9.26 AQP1 MIP
3 transforming growth factor beta binding GO:0050431 9.16 ITGAV TGFBR3
4 water channel activity GO:0015250 8.96 AQP1 MIP
5 fibroblast growth factor binding GO:0017134 8.8 ITGAV KL TGFBR3

Sources for Priapism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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