MCID: PRP007
MIFTS: 55

Priapism malady

Reproductive diseases, Genetic diseases categories

Summaries for Priapism

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63Wikipedia, 32MalaCards
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Wikipedia:63 Priapism (/ˈpraɪəpɪzəm/) is a potentially painful medical condition in which the erect penis does... more...

MalaCards: Priapism, also known as priapism, familial idiopathic, is related to sickle cell disease and sickle cell anemia. An important gene associated with Priapism is GLA (galactosidase, alpha), and among its related pathways are O2/CO2 exchange in erythrocytes and Common Pathway. The compounds hg2+ and estrogen have been mentioned in the context of this disorder. Affiliated tissues include prostate, myeloid and spinal cord, and related mouse phenotypes are reproductive system and liver/biliary system.

Aliases & Classifications for Priapism

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

priapism 8 42 10 44 60
priapism, familial idiopathic 42 60
familial idiopathic priapism 42
mentulagra 8


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Disease Ontology8 DOID:9286
ICD9CM27 607.3
MeSH34 D011317
NCIt39 C85022
ICD1025 N48.3

Related Diseases for Priapism

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Priapism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease30.8G6PD, GLA, HP, NOS3
2sickle cell anemia30.5HP, G6PD
3leukemia30.5HP
4prostatitis30.4PDE5A
5adenocarcinoma30.3NPR1, GUCY2C, F13A1, AQP1
6peritonitis30.0AQP1
7fabry disease30.0GLA
8hypertension29.9GUCY2C, NOS3, F5, NPR1, PDE5A
9premature ejaculation29.7PDE5A
10sarcoma29.7F13A1
11hypogonadism29.7GNRH1, PDE5A
12hemoglobinopathy29.7HP, G6PD
13hereditary spherocytosis29.7G6PD, SLC4A1
14antiphospholipid syndrome29.7F5
15polycystic kidney disease, autosomal dominant29.7NOS3, SLC4A1, AQP1
16chronic myeloid leukemia10.2
17myeloid leukemia10.2
18prostate cancer10.2
19purpura10.2
20schizophrenia10.2
21protein c deficiency10.1
22prostate adenocarcinoma10.1
23thalassemia10.1
24low-flow priapism10.1
25beta thalassemia10.0
26protein s deficiency10.0
27paraphimosis10.0
28cocaine abuse10.0
29impotence10.0
30systemic scleroderma10.0
31ischemic optic neuropathy10.0PDE5A
32hyperparathyroidism10.0KL
33vascular disease10.0HP
34hepatitis b10.0CFB
35age related macular degeneration10.0CFB
36pulmonary emphysema10.0KL
37arthritis10.0HP
38colon cancer10.0GUCY2C
39varicocele10.0GNRH1
40blackwater fever10.0G6PD
41polycystic ovary syndrome10.0GNRH1
42infertility10.0GNRH1
43migraine10.0PDE5A
44nephrotic syndrome10.0HP
45cerebrovascular disease10.0F13A1
46pancreatic cancer10.0HP
47hepatitis10.0HP, CFB
48alpha thalassemia10.0G6PD, SLC4A1
49pneumonia10.0PDE4A
50autoimmune hemolytic anemia10.0HP, G6PD

Graphical network of the top 20 diseases related to Priapism:



Diseases related to priapism

Clinical Features for Priapism

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Drugs & Therapeutics for Priapism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Priapism

Search CenterWatch for Priapism

Genetic Tests for Priapism

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Anatomical Context for Priapism

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32MalaCards
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MalaCards organs/tissues related to Priapism:

32
Prostate, Myeloid, Spinal cord, Smooth muscle, Skin, Brain, Kidney, Testes, T cells

Animal Models for Priapism or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Priapism:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5KL, GNRH1, NPR1, CFB, ADORA2B, AQP1
2MP:00053708.4KL, GNRH1, GUCY2C, F5, GLA, HP
3MP:00053678.2KL, GNRH1, ITGAV, GLA, HP, CFB
4MP:00053698.1KL, NPR1, ITGAV, GLA, SLC4A1, NOS3
5MP:00053787.5GNRH1, G6PD, GUCY2C, ITGAV, F5, BLM
6MP:00053977.4KL, GNRH1, G6PD, ITGAV, F13A1, BLM
7MP:00053847.0ITGAV, G6PD, NPR1, GNRH1, KL, BLM
8MP:00053766.6ITGAV, GUCY2C, G6PD, NPR1, GNRH1, KL
9MP:00107686.4F5, ITGAV, GUCY2C, G6PD, NPR1, KL
10MP:00053876.1ITGAV, GUCY2C, NPR1, PDE4A, GNRH1, KL
11MP:00053855.5TGFBR3, KL, PDE4A, NPR1, G6PD, GUCY2C

Publications for Priapism

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Sources:
50PubMed
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Articles related to Priapism:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
The efficacy of the T-shunt procedure and intracavernous tunneling (snake maneuver) for refractory ischemic priapism. (23892191)
2014
2
Response to Commentary to 'Priapism in children: A comprehensive review and clinical guideline' (24172798)
2013
3
Priapism lasting 19 hours with combined use of trazodone and mirtazapine in a patient with history of successfully tolerating each agent as monotherapy. (23469320)
2012
4
High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. (19912496)
2011
5
Continuous epidural blockade for treatment of drug-induced priapism. (21296258)
2011
6
Posttraumatic priapism in child. (21699042)
2011
7
Re: A Prospective Diary Study of Stuttering Priapism in Adolescents and Young Men With Sickle Cell Anemia: Report of an International Randomized Control Trial; the Priapism in Sickle Cell Study (PISCES study). (22088730)
2011
8
A case of relapsing priapism associated with long-acting injectable risperidone. (21731842)
2011
9
Priapism due to a single dose of quetiapine: a case report. (21870309)
2011
10
Microcoil embolization in post-traumatic high-flow priapism. (21646662)
2011
11
Management of priapism: a case report. (21243861)
2010
12
Erectile function and dysfunction following low flow priapism: a comparison of distal and proximal shunts. (20845293)
2010
13
Fabry disease and G6PD in three family members with priapism: is the nitric oxide pathway to blame? (20102445)
2010
14
Priapism associated with antipsychotics: role of alpha1 adrenoceptor affinity. (20075651)
2010
15
Risperidone-induced priapism: a case report. (19750074)
2009
16
Priapism: a rare complication following epidural analgesia. (19624382)
2009
17
Anxiety disorders in patients with idiopathic priapism: risk factor and pathophysiologic link? (19473462)
2009
18
High-flow priapism complicating ischemic priapism following iatrogenic laceration of the dorsal artery during a Winter procedure. (18431746)
2009
19
Glucose-6-phosphate dehydrogenase deficiency associated stuttering priapism: report of a case. (18823322)
2008
20
Penile prosthesis, spinal anesthesia, and priapism. (18346617)
2008
21
Clitoral priapism with no known risk factors. (19561754)
2008
22
Use of magnetic resonance angiography in diagnosis and decision making of post-traumatic, high-flow priapism. (18301819)
2008
23
Priapism in the oncology setting. (17441393)
2007
24
Posttraumatic high-flow priapism in children: noninvasive treatment by color Doppler ultrasound-guided perineal compression. (17905127)
2007
25
Intermittent priapism in degenerative lumbar spinal stenosis: case report. (18050069)
2007
26
Priapism in children: treatment with embolotherapy. (17415602)
2007
27
Immediate insertion of a semirigid penile prosthesis for refractory ischemic priapism. (18062399)
2007
28
The use of transcatheter superselective embolization to treat high flow priapism (arteriocavernosal fistula) caused by straddle injury. (17644141)
2007
29
Treatment of high-flow priapism with superselective transcatheter embolization in 27 patients: a multicenter study. (17911511)
2007
30
A case report on idiopathic recurrent priapism. (18076427)
2007
31
New-onset priapism associated with ingestion of terazosin in an otherwise healthy man. (17451488)
2007
32
Juvenile posttraumatic high-flow priapism: current management dilemmas. (15852259)
2005
33
High-flow priapism (HFP) secondary to Nesbit operation: management by percutaneous embolization and colour Doppler-guided compression. (15690066)
2005
34
Prostate abscess presenting as priapism. (15875647)
2005
35
Emergency evaluation and treatment of priapism. (15028333)
2004
36
Is antidepressant plus sildenafil a recipe for priapism? (15620123)
2004
37
Idiopathic intracranial hypertension: priapism of the brain? (15288385)
2004
38
Priapism as the presenting symptom of an aortocaval fistula. (14988377)
2004
39
Superselective embolization in posttraumatic priapism with glubran 2 acrylic glue. (15383862)
2004
40
The treatment of priapism--when and how? (14551583)
2003
41
Efficacy of shunt surgery for refractory low flow priapism: a report on the incidence of failed detumescence and erectile dysfunction. (12913722)
2003
42
Olanzapine-associated priapism. (12832606)
2003
43
Priapism associated with two atypical antipsychotic agents. (12173794)
2002
44
Interventional treatment of traumatic priapism. (12431145)
2002
45
Low-flow priapism: risk factors for erectile dysfunction. (11856112)
2002
46
Priapism in sickle-cell disease; incidence, risk factors and complications - an international multicentre study. (12460353)
2002
47
Traumatic arterial priapism: case report and discussion of a rare urologic injury. (12187147)
2002
48
Premature ejaculation, priapism, and Peyronie's disease. (19667521)
2000
49
Priapism in a patient with protein C deficiency. (9352148)
1997
50
Priapism: an unusual complication of parotitis without orchitis. (1271566)
1976

Genetic Variations for Priapism

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Expression for genes affiliated with Priapism

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for genes affiliated with Priapism

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Sources:
53Reactome, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Compounds for genes affiliated with Priapism

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Priapism according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1hg2+4410.4AQP1, GLA
2estrogen4410.2F13A1, PDE5A
3cellulose acetate4410.1CFB, G6PD, HP
4lactose44 1110.9HP, G6PD, GLA
5urea44 11 2411.8HP, F13A1, AQP1, F5
6nitroglycerin44 1110.8NOS3, PDE5A, NPR1
7raloxifene44 28 49 1112.7GNRH1, NOS3, F5
8forskolin44 49 1111.7PDE5A, NPR1, ADORA2B
9vitamin-e449.6HP, F5, G6PD, PDE5A
10kininogen449.6F5, HP, F13A1
11motapizone449.6PDE5A, PDE4A
12glutamate449.6SLC4A1, NPR1, ADORA2B, GLA, GNRH1
13citrate449.5SLC4A1, NOS3, HP, F5, G6PD
14roflumilast44 1110.5PDE4A, PDE5A
15tamoxifen44 49 28 1112.5G6PD, PDE4A, GNRH1
16chloride449.5ADORA2B, AQP1, GUCY2C, SLC4A1
17enprofylline44 1110.5PDE4A, ADORA2B
18methylene449.4PDE4A, G6PD, F5
198-bromo cgmp449.4PDE4A, NPR1, PDE5A
20lactate449.4F5, GNRH1, G6PD, GLA, HP, SLC4A1
21vinpocetine44 2810.4PDE5A, PDE4A
22creatinine449.4HP, GNRH1, F5, G6PD, GLA, AQP1
23erythro-9-(2 hydroxy 3-nonyl)adenine449.4PDE4A, PDE5A
24aspartate449.3GLA, G6PD, PDE4A, GNRH1
25papaverine44 2 1111.3PDE4A, PDE5A, NOS3
26sodium44 2410.2SLC4A1, PDE5A, NPR1, AQP1, HP
27sildenafil44 49 28 11 2413.2PDE4A, PDE5A, NOS3
28serine449.2G6PD, HP, GLA, PDE4A, NPR1
29pentoxifylline44 1110.2GNRH1, HP, PDE5A, PDE4A
30glucose449.2AQP1, SLC4A1, CFB, PDE4A, GLA
31folate449.1G6PD, NOS3, SLC4A1, HP, F5, PDE5A
32glycerol44 11 2411.1G6PD, AQP1, GLA, PDE4A, NOS3
33epinephrine44 11 2411.0GNRH1, PDE4A, G6PD, F5, HP
34phospholipid448.9SLC4A1, HP, PDE4A, F5, GLA, AQP1
35hydrogen44 249.9AQP1, GLA, PDE5A, SLC4A1, PDE4A
36actinomycin d448.9HP, PDE4A, G6PD, GNRH1, NOS3
37pge1448.9ADORA2B, PDE4A, F5, PDE5A
38guanylate448.8PDE4A, PDE5A, NPR1, GUCY2C, NOS3
39prostacyclin448.8NOS3, PDE5A, PDE4A, F5
40alanine448.7AQP1, SLC4A1, HP, NPR1, F5, GNRH1
41xanthine44 249.7ADORA2B, PDE4A, NOS3
42cgmp44 289.7NPR1, PDE4A, PDE5A, GUCY2C, NOS3, AQP1
43aspirin44 49 28 2411.6G6PD, PDE4A, F5, F13A1, HP, NOS3
44glutamine448.6F13A1, G6PD, PDE5A, PDE4A, F5
45atp44 289.5SLC4A1, PDE4A, HP, NPR1, G6PD, GUCY2C
46sodium nitroprusside448.4GNRH1, AQP1, G6PD, NPR1, PDE5A, PDE4A
47arginine448.3AQP1, GNRH1, PDE4A, NOS3, GLA, F5
48nitric oxide44 11 2410.0PDE5A, SLC4A1, NOS3, NPR1, AQP1, HP
49vegf447.5F13A1, HP, NOS3, KL, F5, ITGAV
50calcium44 49 11 249.6ITGAV, F13A1, GLA, HP, NOS3, ADORA2B

GO Terms for genes affiliated with Priapism

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16Gene Ontology
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Cellular components related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8GNRH1, F5, F13A1, GLA, HP, CFB
2integral to plasma membraneGO:0058878.0TGFBR3, KL, NPR1, ITGAV, SLC4A1, ADORA2B

Biological processes related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.0AQP1, NPR1
2regulation of blood vessel sizeGO:0508809.9NOS3, NPR1
3positive regulation of cGMP biosynthetic processGO:0308289.8NPR1, ADORA2B
4positive regulation of guanylate cyclase activityGO:0312849.8NOS3, ADORA2B
5receptor guanylyl cyclase signaling pathwayGO:0071689.7NPR1, GUCY2C
6blood coagulationGO:0075968.5ITGAV, NOS3, F13A1, F5, PDE5A

Molecular functions related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanylate cyclase activityGO:0043839.9GUCY2C, NPR1
2transforming growth factor beta bindingGO:0504319.3TGFBR3, ITGAV
3protein bindingGO:0055156.4G6PD, GUCY2C, ITGAV, F5, BLM, GLA

Products for genes affiliated with Priapism

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  • Antibodies
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Sources for Priapism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet