MCID: PRP007
MIFTS: 60

Priapism malady

Genetic diseases, Rare diseases, Reproductive diseases, Cardiovascular diseases categories
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Summaries for Priapism

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Wikipedia:65 Priapism (/?pra??p?z?m/) is a potentially painful medical condition in which the erect penis does not... more...

MalaCards based summary: Priapism, also known as priapism, familial idiopathic, is related to sickle cell disease and peyronie's disease. An important gene associated with Priapism is GLA (galactosidase, alpha), and among its related pathways are O2/CO2 exchange in erythrocytes and Effects of nitric oxide. The compounds hg2+ and lactose have been mentioned in the context of this disorder. Affiliated tissues include prostate, myeloid and spinal cord, and related mouse phenotypes are digestive/alimentary and respiratory system.

Disease Ontology:8 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

Aliases & Classifications for Priapism

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Priapism, Aliases & Descriptions:

Name: Priapism 8 42 10 44 62
Priapism, Familial Idiopathic 42 62
 
Mentulagra 8 62
Familial Idiopathic Priapism 42


Classifications:



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Disease Ontology8 DOID:9286
NCIt39 C85022
ICD9CM27 607.3
MeSH34 D011317
ICD1025 N48.3

Related Diseases for Priapism

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Diseases related to Priapism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease31.0NOS3, HP, G6PD, GLA
2peyronie's disease30.7PDE5A
3hemoglobinopathy30.4G6PD, HP
4hereditary spherocytosis30.4SLC4A1, G6PD
5hypertension30.2NOS3, PDE5A, F5
6impotence30.1PDE5A, NOS3, NOS2
7thromboembolism29.9F5, G6PD, NOS3
8pulmonary hypertension29.8PDE5A, NOS2, NOS3
9low-flow priapism10.6
10blood group incompatibility10.5G6PD
11blackwater fever10.5G6PD
12mediterranean spotted fever10.5G6PD
13kernicterus10.5G6PD
14sickle cell anemia10.4
15sexual disorder10.4GNRH1, PDE5A
16acute chest syndrome10.4NOS3
17congenital hemolytic anemia10.4G6PD, HP
18favism10.4G6PD, HP
19glucosephosphate dehydrogenase deficiency10.4G6PD, HP
20hemoglobinuria10.4HP, G6PD
21leukemia10.4
22prostatitis10.4
23hereditary elliptocytosis10.4SLC4A1, G6PD
24central retinal vein occlusion10.4F5
25placental abruption10.3F5
26factor vii deficiency10.3F5
27autoimmune hemolytic anemia10.3G6PD, HP
28methemoglobinemia10.3G6PD, HP
29paroxysmal nocturnal hemoglobinuria, somatic10.3G6PD, HP
30bilirubin metabolic disorder10.3HP, G6PD
31congenital heart disease10.3HP, GLA, PDE5A
32adenocarcinoma10.3
33alpha thalassemia10.3G6PD, SLC4A1
34hemolytic anemia10.2G6PD, HP, SLC4A1
35malaria10.2SLC4A1, HP, G6PD
36arteriosclerosis10.2NOS3
37hellp syndrome10.2F5, HP
38primary hyperoxaluria10.2GLA, G6PD, HP
39prostate cancer10.2
40schizophrenia10.2
41spinal cord injury10.2
42thalassemia10.2
43purpura10.2
44factor xii deficiency10.2F5, F13A1
45coronary artery anomaly10.2HP, PDE5A, NOS3
46ovarian hyperstimulation syndrome10.2GNRH1, F5
47dysfibrinogenemia10.2F13A1, F5
48polycystic kidney disease, autosomal dominant10.2AQP1, NOS3, SLC4A1
49homocystinuria10.2F5, G6PD
50deficiency anemia10.1HP, SLC4A1, G6PD

Graphical network of the top 20 diseases related to Priapism:



Diseases related to priapism

Symptoms for Priapism

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Drugs & Therapeutics for Priapism

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Drug clinical trials:

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Genetic Tests for Priapism

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Anatomical Context for Priapism

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MalaCards organs/tissues related to Priapism:

32
Prostate, Myeloid, Spinal cord, Skin, Brain, Smooth muscle, Kidney, Testes, T cells

Animal Models for Priapism or affiliated genes

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Publications for Priapism

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Articles related to Priapism:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Molecular Pathophysiology of Priapism: Emerging Targets. (25392014)
2014
2
Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma. (25210564)
2014
3
A Case of Painless Pediatric Priapism and Cough. (25285386)
2014
4
Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism. (24076963)
2014
5
Priapism Induced by Boceprevir-CYP3A4 Inhibition and I+-Adrenergic Blockade: Case Report. (24092799)
2014
6
18F-FDG PET/CT in a case of malignant priapism secondary to metastasis from mucoid adenocarcinoma of the cecum. (23334147)
2013
7
Unsatisfactory outcomes of prolonged ischemic priapism without early surgical shunts: our clinical experience and a review of the literature. (22922321)
2013
8
Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress. (23844149)
2013
9
Priapism in children: a comprehensive review and clinical guideline. (24135215)
2013
10
High flow priapism on color Doppler ultrasound. (23473902)
2013
11
A pathophysiology-based approach to the management of early priapism. (23202699)
2013
12
Castration for treating recurrent priapism: can we do better? (21799141)
2012
13
Priapism: comorbid factors and treatment outcomes in a contemporary series. (22811705)
2012
14
The use of sudafed for priapism in pediatric patients with sickle cell disease. (22041221)
2012
15
High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. (19912496)
2011
16
Treating stuttering priapism. (21914108)
2011
17
Early insertion of inflatable prosthesis for intractable ischemic priapism: our experience and review of the literature. (21654814)
2011
18
Daily phosphodiesterase type 5 inhibitor therapy as rescue for recurrent ischemic priapism after failed androgen ablation. (21127306)
2011
19
A crackling priapism related to Fournier's gangrene in a patient on chronic peritoneal dialysis. (20600298)
2010
20
Favorable response to intrathecal, but not oral, baclofen of priapism in a patient with spinal cord injury. (19179913)
2009
21
Posttraumatic high-flow priapism: case report, current management options and literature review. (19623873)
2009
22
Investigating the effects of high-dose phenylephrine in the management of prolonged ischaemic priapism. (18466270)
2008
23
Posttraumatic nonischemic priapism treated with autologous blood clot embolization. (18173765)
2008
24
Sickle cell trait and priapism: a case report and review of the literature. (19116025)
2008
25
Glucose-6-phosphate dehydrogenase deficiency associated stuttering priapism: report of a case. (18823322)
2008
26
Sickle cell disease status and outcomes of African-American men presenting with priapism. (18312286)
2008
27
Superselective arterial embolization for patients with high-flow priapism: results of follow-up for five or more years. (17453510)
2007
28
Association between priapism and concurrent use of risperidone and Ginkgo biloba. (17908535)
2007
29
Priapism in the oncology setting. (17441393)
2007
30
The Winter procedure as management for prolonged low-flow priapism: a case report. (18055300)
2007
31
Stuttering priapism after ingestion of alfuzosin. (17070382)
2006
32
High-flow priapism as a complication of a veno-occlusive priapism: two case reports. (16224494)
2006
33
Priapism: new concepts in the pathophysiology and new treatment strategies. (17052448)
2006
34
Is the combination of superselective transcatheter autologous clot embolization and duplex sonography-guided compression therapy useful treatment option for the patients with high-flow priapism? (16079900)
2006
35
Distal cavernosum-glans shunts for ischemic priapism. (16839333)
2006
36
Irreversible priapism during olanzapine and lithium therapy. (15144518)
2004
37
Priapism following ingestion of tamsulosin. (12771780)
2003
38
Priapism secondary to hypertriglyceridemia. (12576856)
2003
39
Evidence-based radiology problems. High-flow post-traumatic priapism: transcatheter embolotherapy: October 2003-September 2004. (14593770)
2003
40
The incidence and management of priapism in Western Australia: a 16 year audit. (12934055)
2003
41
Priapism associated with two atypical antipsychotic agents. (12173794)
2002
42
Management strategy for arterial priapism: therapeutic dilemmas. (12394712)
2002
43
Interventional treatment of traumatic priapism. (12431145)
2002
44
The management of low-flow priapism with the immediate insertion of a penile prosthesis. (12460352)
2002
45
Unusual complications of warfarin therapy: skin necrosis and priapism. (10931425)
2000
46
Re: Chronic myeloid leukaemia presenting as priapism in children: need for multidisciplinary approach. (12862132)
2000
47
Priapism in a patient with protein C deficiency. (9352148)
1997
48
Permanent open shunt as a reason for impotence or reduced potency after surgical treatment of priapism in 26 patients. (8750051)
1995
49
Priapism associated with chronic cocaine abuse. (8042894)
1994
50
Priapism associated with intranasal cocaine abuse. (2304177)
1990

Variations for Priapism

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Expression for genes affiliated with Priapism

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Expression patterns in normal tissues for genes affiliated with Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for genes affiliated with Priapism

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Pathways related to Priapism according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9AQP1, SLC4A1
2
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis37
9.5NOS3, NOS2
39.5NOS3, NOS2
4
Show member pathways
9.5NOS3, NOS2
5
Show member pathways
9.1NOS3, ITGAV, TGFBR3
69.1TGFBR3, NOS3, ITGAV
7
Show member pathways
8.9NOS3, NOS2, PDE5A
88.9NOS3, NOS2, PDE5A
9
Show member pathways
8.9NOS3, PDE5A, NOS2
10
Show member pathways
8.7NOS3, ITGAV, GNRH1, TGFBR3
118.7ADORA2B, NOS2, NOS3
12
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
8.6ADORA2B, ITGAV, NOS3
13
Show member pathways
8.2NOS3, NOS2, GLA, KL, G6PD, AQP1
14
Show member pathways
7.6F5, F13A1, ITGAV, PDE5A, NOS2, NOS3

Compounds for genes affiliated with Priapism

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Compounds related to Priapism according to GeneCards/GeneDecks:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1hg2+4410.3AQP1, GLA
2lactose44 1110.9HP, GLA, G6PD
3magnesium lithospermate b449.9NOS2, NOS3
4l-thiocitrulline44 1110.9NOS2, NOS3
5s-ethylisothiourea44 1110.9NOS2, NOS3
6n5-(1-iminoethyl)-l-ornithine449.8NOS2, NOS3
7nitrit449.8NOS2, NOS3
8n-(3-(aminomethyl)benzyl)acetamidine44 1110.8NOS2, NOS3
9n(g)-hydroxy-l-arginine449.8NOS3, NOS2
103-bromo-7-nitroindazole61 1110.8NOS2, NOS3
117-nitroindazole44 1110.8NOS3, NOS2
12kininogen449.7F13A1, HP, F5
13vitamin b12449.6HP, G6PD, F5
14malondialdehyde449.6F5, G6PD, HP
15urea44 24 1111.6F5, HP, AQP1, F13A1
16glycerol44 24 1111.6G6PD, NOS3, AQP1, GLA
17raloxifene44 50 28 1112.5NOS3, GNRH1, F5
18pentoxifylline44 1110.5GNRH1, HP, PDE5A
19diphenyleneiodonium449.5NOS2, G6PD, NOS3
20phospholipid449.4F5, GLA, AQP1, SLC4A1, HP
21epinephrine44 24 1111.4GNRH1, G6PD, F5, HP
22n(g),n(g)-dimethylarginine449.4NOS3, NOS2
23aspartate449.3F5, G6PD, HP, GLA, GNRH1
24vitamin-e449.3G6PD, PDE5A, F5, HP
25kt 582344 2810.3PDE5A, NOS2, NOS3
26sildenafil28 44 50 24 1113.3NOS3, PDE5A, NOS2
27nitroglycerin44 1110.2NOS3, PDE5A, NOS2
28peroxynitrite449.2SLC4A1, NOS2, NOS3
29nitrate449.2PDE5A, NOS3, NOS2
30citrate449.1SLC4A1, NOS3, F5, HP, G6PD
31creatinine449.1GLA, F5, HP, G6PD, GNRH1, AQP1
32lactate449.1GLA, F5, HP, G6PD, GNRH1, SLC4A1
33aspirin44 50 28 2412.1HP, F13A1, G6PD, NOS3, F5
34cgmp44 2810.0NOS2, NOS3, AQP1, PDE5A
35actinomycin d449.0NOS2, NOS3, GNRH1, HP, G6PD
36tamoxifen44 50 28 1112.0F5, GNRH1, G6PD, NOS3
37ascorbic acid44 249.9NOS3, NOS2, F5, G6PD, HP
38prostacyclin448.9NOS3, F5, PDE5A, NOS2
39testosterone44 61 24 1111.7GNRH1, G6PD, HP, PDE5A, F5
40fibrinogen448.6ITGAV, F5, HP, F13A1
41adenylate448.6NOS2, HP, ADORA2B, GNRH1, G6PD
42pge1448.6F5, PDE5A, ADORA2B
43folate448.5PDE5A, G6PD, SLC4A1, NOS3, HP, F5
44sodium nitroprusside448.4GNRH1, AQP1, PDE5A, NOS2, NOS3, G6PD
45arginine448.1GNRH1, NOS3, NOS2, GLA, PDE5A, F5
46nitric oxide44 24 119.9GLA, NOS2, NOS3, PDE5A, HP, AQP1
47estrogen447.7NOS2, F5, PDE5A, HP, G6PD, F13A1
48glutamate447.6NOS2, NOS3, SLC4A1, F5, HP, ADORA2B
49vegf447.3NOS3, F13A1, AQP1, ITGAV, HP, PDE5A
50calcium44 50 24 119.2AQP1, F13A1, ADORA2B, ITGAV, NOS3, NOS2

GO Terms for genes affiliated with Priapism

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Cellular components related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cortical cytoskeletonGO:0308639.7NOS2, SLC4A1
2blood microparticleGO:0725629.5HP, SLC4A1, F13A1
3extracellular regionGO:0055768.7GLA, F13A1, KL, F5, HP, GNRH1
4extracellular spaceGO:0056158.6KL, F5, HP, TGFBR3, GNRH1
5extracellular vesicular exosomeGO:0700628.3SLC4A1, TGFBR3, AQP1, G6PD, ITGAV, HP
6integral component of plasma membraneGO:0058878.0KL, SLC4A1, AQP1, TGFBR3, ADORA2B, ITGAV

Biological processes related to Priapism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1bicarbonate transportGO:0157019.8AQP1, SLC4A1
2arginine catabolic processGO:0065279.7NOS3, NOS2
3nitric oxide biosynthetic processGO:0068099.6NOS3, NOS2
4nitric oxide mediated signal transductionGO:0072639.6NOS2, NOS3
5negative regulation of blood pressureGO:0457769.6NOS2, NOS3
6positive regulation of vasodilationGO:0459099.5NOS2, NOS3
7interaction with hostGO:0517019.2NOS3, NOS2
8positive regulation of guanylate cyclase activityGO:0312848.9NOS3, ADORA2B, NOS2
9small molecule metabolic processGO:0442818.9AQP1, G6PD, NOS3, SLC4A1, GLA
10blood coagulationGO:0075967.8F5, NOS2, NOS3, ITGAV, F13A1, PDE5A

Molecular functions related to Priapism according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:0045179.7NOS3, NOS2
2tetrahydrobiopterin bindingGO:0346179.7NOS3, NOS2
3arginine bindingGO:0346189.6NOS3, NOS2
4NADPH-hemoprotein reductase activityGO:0039589.6NOS3, NOS2
5fibroblast growth factor bindingGO:0171349.6TGFBR3, KL
6FMN bindingGO:0101819.5NOS2, NOS3
7transforming growth factor beta bindingGO:0504319.5TGFBR3, ITGAV
8NADP bindingGO:0506619.4G6PD, NOS2, NOS3
9protein homodimerization activityGO:0428039.2G6PD, NOS2, SLC4A1, GLA
10protein bindingGO:0055156.9ITGAV, SLC4A1, NOS3, NOS2, GLA, F5

Products for genes affiliated with Priapism

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Sources for Priapism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet