MCID: PRP007
MIFTS: 45

Priapism

Categories: Rare diseases, Reproductive diseases, Cardiovascular diseases, Genetic diseases

Aliases & Classifications for Priapism

MalaCards integrated aliases for Priapism:

Name: Priapism 12 50 52 42 14 69
Priapism, Familial Idiopathic 50 69
Familial Idiopathic Priapism 50
Mentulagra 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9286
ICD10 33 N48.3 N48.30
ICD9CM 35 607.3
MeSH 42 D011317
NCIt 47 C85022
UMLS 69 C0033117

Summaries for Priapism

Disease Ontology : 12 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

MalaCards based summary : Priapism, also known as priapism, familial idiopathic, is related to low-flow priapism and persistent genital arousal disorder, and has symptoms including painful erection An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Apoptosis Pathway. The drugs Prazosin and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include myeloid, prostate and spinal cord, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after... more...

Related Diseases for Priapism

Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
id Related Disease Score Top Affiliating Genes
1 low-flow priapism 12.1
2 persistent genital arousal disorder 11.2
3 epithelial predominant pulmonary blastoma 10.4 NOS3 PDE5A
4 traumatic glaucoma 10.4 NOS3 PDE5A
5 munchausen by proxy 10.4 NOS3 PDE5A
6 myxomatous pattern testicular yolk sac tumor 10.4 F5 NOS3
7 bernard-soulier syndrome, type a2 10.3 NOS3 PDE5A
8 inherited blood coagulation disease 10.3 F13A1 F5
9 dyskeratosis congenita autosomal recessive 10.3 F13A1 F5
10 sickle cell disease 10.2
11 stuttering 10.2
12 preeclampsia/eclampsia 1 10.1 F5 NOS3
13 ovarian hyperstimulation syndrome 10.1 F5 GNRH1
14 retroperitoneal sarcoma 10.1 GNRH1 NOS3
15 hepatocellular adenoma 10.1 F5 NOS3 PDE5A
16 joint disorders 10.1 F5 NOS3 PDE5A
17 leukemia 10.0
18 pregnancy loss, recurrent 2 10.0 F13A1 F5
19 viral hepatitis 10.0 NOS3 PDE5A
20 sickle cell anemia 10.0
21 prostatitis 10.0
22 myeloid leukemia 9.9
23 thrombosis 9.9
24 adenocarcinoma 9.9
25 cervix squamous papilloma 9.8 AQP1 F5
26 schizophrenia 9.8
27 spinal cord injury 9.8
28 thalassemia 9.8
29 prostate cancer 9.8
30 purpura 9.8
31 dentine erosion 9.7 F13A1 F5
32 prostate adenocarcinoma 9.7
33 protein c deficiency 9.7
34 multiple myeloma 9.6
35 fabry disease 9.6
36 lymphoma 9.6
37 impotence 9.6
38 protein s deficiency 9.6
39 paraphimosis 9.6
40 cocaine abuse 9.6
41 peritonitis 9.6
42 thalassemia intermedia 9.6
43 myocardial infarction 9.6 F13A1 F5 NOS3 PDE5A
44 systemic lupus erythematosus 9.5
45 esophageal cancer 9.5
46 renal cell carcinoma 9.5
47 chordoma 9.5
48 hypertriglyceridemia 9.5
49 pick disease 9.5
50 peyronie's disease 9.5

Graphical network of the top 20 diseases related to Priapism:



Diseases related to Priapism

Symptoms & Phenotypes for Priapism

UMLS symptoms related to Priapism:


painful erection

MGI Mouse Phenotypes related to Priapism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 AQP1 F13A1 F5 ITGAV KL NOS3
2 hematopoietic system MP:0005397 9.87 TGFBR3 AQP1 F13A1 GNRH1 ITGAV KL
3 endocrine/exocrine gland MP:0005379 9.85 AQP1 F13A1 GNRH1 ITGAV KL NOS3
4 homeostasis/metabolism MP:0005376 9.8 KL NOS3 AQP1 F13A1 F5 GNRH1
5 liver/biliary system MP:0005370 9.55 F5 GNRH1 KL NOS3 TGFBR3
6 renal/urinary system MP:0005367 9.35 AQP1 GNRH1 ITGAV KL NOS3
7 reproductive system MP:0005389 9.1 AQP1 F13A1 GNRH1 KL NOS3 TGFBR3

Drugs & Therapeutics for Priapism

Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prazosin Approved Phase 3 19216-56-9 4893
2 Adrenergic Agents Phase 3
3 Adrenergic alpha-1 Receptor Antagonists Phase 3
4 Adrenergic alpha-Antagonists Phase 3
5 Adrenergic Antagonists Phase 3
6 Antihypertensive Agents Phase 3
7 Neurotransmitter Agents Phase 3
8
Hydroxyurea Approved Phase 2 127-07-1 3657
9 Phosphodiesterase 5 Inhibitors Phase 2
10 Phosphodiesterase Inhibitors Phase 2
11 Sildenafil Citrate Phase 2 171599-83-0
12 Vasodilator Agents Phase 2
13 Antibodies Phase 2
14 Antibodies, Monoclonal Phase 2
15 Immunoglobulins Phase 2
16 Nucleic Acid Synthesis Inhibitors Phase 2
17 Citrate Nutraceutical Phase 2
18
Citric Acid Nutraceutical, Vet_approved Phase 2 77-92-9 311

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 AScVS and/ or Prazosin for Scorpion Envenomation Completed NCT00753064 Phase 3 Antiscorpion venom serum(AScVS).;T.Prazosin;AScVS + Prazosin
2 Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy Withdrawn NCT01560091 Phase 3 silodosin;Tamsulosin
3 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed NCT00940901 Phase 2 sildenafil
4 Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises Completed NCT01895361 Phase 2 SelG1;Placebo
5 Pharmacokinetics and Pharmacodynamics Study of SEG101 (Crizanlizumab) in Adult Sickle Cell Disease (SCD) Patients With Vaso- Occlusive Crisis (VOC) Not yet recruiting NCT03264989 Phase 2 crizanlizumab
6 Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia Withdrawn NCT00538564 Phase 2 tadalafil;placebo
7 Priapism in Boys and Men With Sickle Cell Disease - Demographics, Characteristics and Prevalence Completed NCT00300235
8 Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events Recruiting NCT02539771
9 Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose Recruiting NCT03114137
10 Androgen Regulation of Priapism in Sickle Cell Disease Withdrawn NCT01940718 Early Phase 1 Transdermal Androgel

Search NIH Clinical Center for Priapism

Cochrane evidence based reviews: priapism

Genetic Tests for Priapism

Anatomical Context for Priapism

MalaCards organs/tissues related to Priapism:

39
Myeloid, Prostate, Spinal Cord, Heart, Brain, Skin, Smooth Muscle

Publications for Priapism

Articles related to Priapism:

(show top 50) (show all 639)
id Title Authors Year
1
Prognostic Factors and Outcome of Management of Ischemic Priapism in Zaria, Nigeria. ( 28584506 )
2017
2
Priapism in the Newborn: Shall We Intervene? ( 28083497 )
2017
3
Guideline of guidelines: priapism. ( 27860090 )
2017
4
Management in Neonatal Priapism: Case and Review. ( 28752068 )
2017
5
The Semantics of Priapism and the First Sign of Chronic Myeloid Leukemia. ( 28638667 )
2017
6
Contemporary best practice in the evaluation and management of stuttering priapism. ( 28932276 )
2017
7
Ischemic priapism: Can eosinophil count and platelet functions be positive predictive factors in etiopathogenesis. ( 28761591 )
2017
8
Priapism with penile gangrene: An unusual presentation of multiple myeloma. ( 28717280 )
2017
9
Ultrasound-guided penile nerve block in pediatrics: An answer to intraoperative priapism. ( 28757858 )
2017
10
Priapism due to essential thrombocythaemia: a rare causation. ( 28824001 )
2017
11
Emergency Department Management Of Priapism. ( 28027457 )
2017
12
The management of the acute ischemic priapism: A state of the art review. ( 28528136 )
2017
13
Advances in the understanding of priapism. ( 28540227 )
2017
14
Penile Prosthesis Implantation in Priapism. ( 28916463 )
2017
15
Priapism associated with the addition of risperidone to methylphenidate monotherapy: a case report. ( 28752150 )
2017
16
Avoiding complications: surgery for ischemic priapism. ( 28904898 )
2017
17
Emergency department management of priapism [digest]. ( 28745844 )
2017
18
Treatments for priapism in boys and men with sickle cell disease. ( 28926088 )
2017
19
Postoperative drug-induced priapism. ( 28566410 )
2017
20
Conversion of Low-Flow Priapism to High-Flow State Using T-Shunt with Tunneling. ( 28331646 )
2017
21
Priapism Associated With Antipsychotic Medication Use: Case Report. ( 28590368 )
2017
22
Leech Therapy for Treating Priapism: Case Report. ( 28845411 )
2017
23
Management of refractory ischemic priapism: current perspectives. ( 28920056 )
2017
24
Thalassemia Major and Priapism: A Case Report of an Adolescent. ( 28538505 )
2017
25
Poster 321 Trazodone Associated Clitoral Priapism in a Transgender Man following Traumatic Brain Injury: A Case Report. ( 27673077 )
2016
26
Risperidone-induced priapism in an autistic child: a case report. ( 27266696 )
2016
27
Steroids, drugs and stuttering priapism; the rock-and-roll lifestyle of a 24-year-old man. ( 26822610 )
2016
28
Clinical Management of Priapism: A Review. ( 27169123 )
2016
29
Beneficial effect of the nitric oxide donor compound 3-(1,3-dioxoisoindolin-2-yl)benzyl nitrate on dysregulated phosphodiesterase 5, NADPH oxidase and nitrosative stress in the sickle cell mouse penis: implication for priapism treatment. ( 27540002 )
2016
30
Ischemic priapism in South-East Nigeria: Presentation, management challenges, and aftermath issues. ( 26856282 )
2016
31
Emergency Department Visits and Inpatient Admissions Associated with Priapism among Males with Sickle Cell Disease in the United States, 2006-2010. ( 27078839 )
2016
32
Homocysteinemia: A rare cause of priapism. ( 26834419 )
2016
33
Priapism as a new symptom of anaphylaxis in a prepubescent child. ( 27496320 )
2016
34
Recurring priapism may be a symptom of voiding dysfunction - case report and literature review. ( 27256196 )
2016
35
al-Ghorab Shunt for Priapism. ( 27436080 )
2016
36
Intracavernosal metaraminol bitartrate for treatment of priapism resulting from circumcision: a case report. ( 27104124 )
2016
37
Nonischaemic priapism associated with selective serotonin-3 receptor antagonist. ( 27709642 )
2016
38
Ethylene-vinyl alcohol copolymer (Onyx(Ar)) transarterial embolization for post-traumatic high-flow priapism. ( 27429919 )
2016
39
Use of amisulpride in treating adolescent onset schizophrenia associated with stuttering priapism induced by multiple antipsychotics. ( 26957345 )
2016
40
Correction: Emergency Department Visits and Inpatient Admissions Associated with Priapism among Males with Sickle Cell Disease in the United States, 2006-2010. ( 27557148 )
2016
41
Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? ( 27408418 )
2016
42
Noninvasive treatments for iatrogenic priapism: Do they really work? A prospective multicenter study. ( 27141191 )
2016
43
Malignant priapism due to penile metastases: Case series and literature review. ( 27377094 )
2016
44
A case of carbamazepine-induced priapism. ( 27285395 )
2016
45
Priapism - A Rare Presentation in Chronic Myeloid Leukemia: CaseA Report. ( 26793565 )
2016
46
Use of High-Dose Phenylephrine in the Treatment of Ischemic Priapism: Five-Year Experience at a Single Institution. ( 27692841 )
2016
47
Outcome and erectile function following treatment of priapism: An institutional experience. ( 26834401 )
2016
48
Risk Factors for Priapism Readmission. ( 27496074 )
2016
49
Priapism as the Presenting Complaint in Fatal Group A Streptococcal Induced Disseminated Intravascular Coagulation. ( 27989251 )
2016
50
High Flow Priapism in a Pediatric Patient after Circumcision with Dorsal Penile Nerve Block. ( 27648333 )
2016

Variations for Priapism

Expression for Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for Priapism

Pathways related to Priapism according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 F13A1 F5 ITGAV NOS3 PDE5A
2
Show member pathways
11.85 ITGAV NOS3 TGFBR3
3
Show member pathways
10.94 NOS3 PDE5A
4 10.74 ITGAV NOS3 TGFBR3
5 10.07 NOS3 PDE5A

GO Terms for Priapism

Cellular components related to Priapism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.96 F13A1 F5
2 caveola GO:0005901 8.85 NOS3
3 axon terminus GO:0043679 8.62 AQP1 GNRH1

Biological processes related to Priapism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell growth GO:0016049 9.16 ITGAV TGFBR3
2 hemostasis GO:0007599 8.96 F13A1 F5
3 response to prostaglandin E GO:0034695 8.62 GNRH1 TGFBR3

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.16 ITGAV TGFBR3
2 transforming growth factor beta binding GO:0050431 8.96 ITGAV TGFBR3
3 fibroblast growth factor binding GO:0017134 8.8 ITGAV KL TGFBR3

Sources for Priapism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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