Priapism malady

Wikipedia: Priapism (/ˈpraɪəpɪzəm/) is a potentially painful medical condition, in which the erect penis or...⁴⁴ more...

MalaCards: Priapism, also known as priapism, familial idiopathic, is related to fabry disease and hypertension. An important gene associated with Priapism is PDE5A (phosphodiesterase 5A, cGMP-specific), and among its related pathways are NO-dependent CFTR activation (normal and CF) and Common Pathway. The compounds nitroglycerin and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include skin and b cells, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Descriptions:

priapism 6 30 8 32 43 priapism, familial idiopathic 30 familial idiopathic priapism 30

priapism (disorder) 6 mentulagra 6

Diseases related to priapism by text searches and GeneDecks gene sharing:

(show top 50)    (show all 170)

id	Related Disease	Score	Top Affiliating Genes
1	fabry disease	28.3	F5, GLA, NOS3
2	hypertension	27.5	NOS2, NOS3
3	pulmonary hypertension	26.5	PDE4A, NOS2, NOS3, PDE5A
4	sickle cell disease	24.1	KL, ITGAV, AQP1, F5, F13A1, GLA
5	fibrosis	22.0	KL, PDE4A, ITGAV, GUCY2C, AQP1, F5
6	blackwater fever	13.3	HP, G6PD
7	low compliance bladder	13.2	PDE4A, PDE5A
8	peyronie's disease	13.2	NOS2, PDE5A
9	favism	13.2	HP, G6PD
10	congenital hemolytic anemia	13.2	HP, G6PD
11	glucosephosphate dehydrogenase deficiency	13.1	HP, G6PD
12	sexual disorder	13.0	PDE4A, PDE5A
13	elliptocytosis	13.0	HP, G6PD, SLC4A1
14	hemolytic anemia	13.0	HP, G6PD, SLC4A1
15	factor xii deficiency	12.9	F5, F13A1
16	hereditary elliptocytosis	12.9	G6PD, SLC4A1
17	malaria, resistance to	12.8	NOS2, SLC4A1
18	arterial occlusive disease	12.8	KL, F5, HP
19	cerebral malaria	12.8	HP, NOS2, G6PD
20	peyronies disease	12.8	PDE4A, NOS2, PDE5A
21	congenital hypothyroidism	12.7	HP, NOS2, G6PD
22	pulmonary embolism	12.7	F5, F13A1, PDE5A
23	dyspepsia	12.7	PDE4A, NOS2, PDE5A
24	polycystic kidney disease, autosomal dominant	12.7	AQP1, NOS3, SLC4A1
25	varicocele	12.6	AQP1, GNRH1, GLA, NOS2
26	pulmonary emphysema	12.6	KL, NOS3, TGFBR3
27	secondary hyperparathyroidism of renal origin	12.5	KL, AQP1, GNRH1, TGFBR3, SLC4A1
28	gigantism	12.5	F5, F13A1, GLA, NPR1
29	hemoglobinopathy	12.5	BLM, CFB, HP, G6PD, SLC4A1
30	mayer-rokitansky-kuster-hauser syndrome	12.5	BLM, CFB, GNRH1, G6PD
31	laryngeal carcinoma	12.5	AQP1, F13A1, HP, NOS2
32	plasmodium falciparum malaria	12.5	HP, NOS2, G6PD
33	impotence	12.5	NOS2, NOS3, PDE5A
34	hereditary spherocytosis	12.5	F5, HP, G6PD, SLC4A1
35	spherocytosis	12.4	F5, HP, G6PD, SLC4A1
36	autoimmune hemolytic anemia	12.4	F5, HP, G6PD, SLC4A1
37	hemorrhagic shock and encephalopathy syndrome	12.4	NOS2, NOS3
38	primary pulmonary hypertension	12.4	PDE4A, F5, PDE5A, TGFBR3
39	diarrhea	12.4	CFB, GUCY2C, G6PD, NPR1
40	cluster headache	12.3	HP, NOS2, NOS3
41	chronic kidney failure	12.3	AQP1, GLA, HP, NOS3
42	acute chest syndrome	12.2	BLM, CFB, NOS3, G6PD
43	colonic disease	12.2	F5, NOS2
44	hereditary hemorrhagic telangiectasia	12.2	F5, NOS3, TGFBR3
45	pulmonary edema	12.2	AQP1, HP, NOS2, NOS3
46	lupus nephritis	12.2	CFB, GLA, NOS2, NOS3
47	patent ductus arteriosus	12.1	F5, F13A1, HP, NOS2
48	osteomyelitis	12.1	BLM, NOS2, NOS3
49	cerebral aneurysms	12.1	PDE4A, NOS2, NOS3
50	polyneuropathy	12.1	CFB, HP, NOS2, NOS3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to priapism:

²²

MGI Mouse Phenotypes related to priapism:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	9.5	GUCY2C, GLA, NOS3
2	hematopoietic system phenotype	MP:0005397	9.3	TGFBR3, F13A1, AQP1, BLM
3	reproductive system phenotype	MP:0005389	8.8	ADORA2B, NPR1, TGFBR3, NOS2, GNRH1
4	immune system phenotype	MP:0005387	8.4	SLC4A1, NPR1, GNRH1, GUCY2C, ITGAV, CFB
5	muscle phenotype	MP:0005369	8.1	NPR1, TGFBR3, NOS3, NOS2, ITGAV, KL
6	growth/size phenotype	MP:0005378	7.6	SLC4A1, NOS3, GNRH1, AQP1, GUCY2C, ITGAV
7	renal/urinary system phenotype	MP:0005367	7.4	SLC4A1, NOS3, NOS2, HP, GLA, GNRH1
8	cellular phenotype	MP:0005384	6.2	G6PD, TGFBR3, NPR1, SLC4A1, ADORA2B, NOS3
9	homeostasis/metabolism phenotype	MP:0005376	5.3	NOS2, NOS3, G6PD, NPR1, SLC4A1, ADORA2B
10	mortality/aging	MP:0010768	5.2	NOS3, G6PD, TGFBR3, NPR1, SLC4A1, ADORA2B
11	cardiovascular system phenotype	MP:0005385	4.7	KL, ADORA2B, SLC4A1, NPR1, TGFBR3, G6PD

Articles related to priapism:

(show all 14)

id	Title	Authors	Year	Affiliating Genes
1	Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling. (19858092)	Wen J.... Xia Y.	2010	ADORA2B
2	Sickle cell trait and priapism: a case report and review of the literature. (19116025)	Birnbaum B.F.... Pinzone J.J.	2008	PDE5A
3	Glucose-6-phosphate dehydrogenase deficiency associated stuttering priapism: report of a case. (18823322)	Finley D.S.	2008	G6PD, GNRH1
4	Glucose-6-phosphate dehydrogenase deficiency: an etiology for idiopathic priapism? (17971109)	Burnett A.L.... Bivalacqua T.J.	2008	PDE5A
5	Genetic polymorphisms associated with priapism in sickle cell disease. (17408468)	Elliott L.... Telen M.J.	2007	NOS3, SLC4A1, ITGAV
6	Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. (17100941)	Burnett A.L.... Musicki B.	2006	PDE5A
7	Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. (16291595)	Kato G.J.... Gladwin M.T.	2006	HP
8	Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism. (16698365)	Burnett A.L.... Musicki B.	2006	PDE5A
9	Priapism and activated protein C resistance (15999622)	Guichard G.... Kleinclauss F.	2005	F5
10	Association of single nucleotide polymorphisms in klotho with priapism in sickle cell anaemia. (15638863)	Nolan V.G.... Steinberg M.H.	2005	KL
11	Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism. (12853767)	Lin G.... Lin C.S.	2003	PDE5A
12	Unusual complications of warfarin therapy: skin necrosis and priapism. (10931425)	Zimbelman J.... Nuss R.	2000	F5
13	Priapism and Fabry disease: a case report. (2161340)	GarcA-a-Consuegra J.... Ramos J.	1990	GLA
14	Priapism associated with Fabry's disease (2127372)	Jaureguizar Monereo E.... LA^pez SantamarA-a M.	1990	GLA

Genes related to priapism according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	PDE5A	phosphodiesterase 5A, cGMP-specific	11.0	Publications
2	ADORA2B	adenosine A2b receptor	11.0	Publications
3	KL	klotho	11.0	Publications
4	GLA	galactosidase, alpha	11.0	Publications
5	AQP1	aquaporin 1 (Colton blood group)	11.0	Publications
6	NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	11.0
7	PPIP5K2	diphosphoinositol pentakisphosphate kinase 2	11.0
8	CFB	complement factor B	11.0
9	SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	11.0	Publications
10	GUCY2C	guanylate cyclase 2C (heat stable enterotoxin receptor)	11.0
11	TGFBR3	transforming growth factor, beta receptor III	11.0	Publications
12	ITGAV	integrin, alpha V	11.0	Publications
13	HP	haptoglobin	11.0	Publications
14	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
15	BLM	Bloom syndrome, RecQ helicase-like	11.0
16	F13A1	coagulation factor XIII, A1 polypeptide	11.0	Publications
17	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
18	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0
19	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
20	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
21	NOS2	nitric oxide synthase 2, inducible	11.0	Publications

Pathways related to priapism according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	NO-dependent CFTR activation (normal and CF)41	9.3	NOS2, NOS3, PDE5A
2	Common Pathway38	9.2	F5, F13A1
3	Purine metabolism20	9.2	NPR1, PDE5A, GUCY2C, PDE4A
4	Complement and coagulation cascades20	9.0	CFB, F5, F13A1
5	Angiogenesis3	9.0	ITGAV, NOS3, TGFBR3
6	Sertoli-Sertoli Cell Junction Dynamics36	8.9	NPR1, TGFBR3, NOS3, GUCY2C, ITGAV
7	eNOS Signaling36	8.9	NPR1, NOS3, GNRH1, AQP1, GUCY2C
8	Cellular Effects of Sildenafil36	8.8	PDE4A, GUCY2C, NOS3, PDE5A, NPR1

Compounds related to priapism according to GeneDecks:

(show top 50)    (show all 90)

id	Compound	Score	Top Affiliating Genes
1	nitroglycerin32 9 9	12.7	NPR1
2	ascorbic acid32 18	11.3	G6PD
3	guanylate32	10.2	NPR1, PDE5A, GUCY2C
4	motapizone32	10.1	PDE4A, PDE5A
5	hg2+32	10.1	AQP1, GLA
6	glutamate32	9.9	ADORA2B, SLC4A1, GLA, GNRH1
7	roflumilast32	9.8	PDE5A, PDE4A
8	6-Nitroindazole9 9	10.7	NOS2, NOS3
9	citrate32	9.7	NOS3, HP, SLC4A1
10	Ethylisothiourea9 9	10.7	NOS3, NOS2
11	magnesium lithospermate b32	9.7	NOS3, NOS2
12	vardenafil32 9 9	11.7	NOS2, PDE5A, PDE4A
13	ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE9 9	10.7	NOS3, NOS2
14	N,N-dimethylarginine9 9	10.7	NOS2, NOS3
15	5-Nitroindazole9 9	10.7	NOS2, NOS3
16	papaverine32 9 9	11.6	PDE4A, PDE5A, NOS3
17	s-ethylisothiourea32 9 9	11.6	NOS3, NOS2
18	sodium nitroprusside32	9.6	PDE4A, G6PD, NPR1, PDE5A
19	kt 582332	9.5	NOS2, PDE5A, NOS3
20	3-bromo-7-nitroindazole42 9 9	11.5	NOS2, NOS3
21	pentoxifylline32 9 9	11.5	HP, PDE4A, GNRH1, PDE5A
22	n-(3-(aminomethyl)benzyl)acetamidine32 9 9	11.5	NOS2, NOS3
23	nitrit32	9.5	NOS3, NOS2
24	8-bromo cgmp32	9.5	NPR1, PDE5A, NOS2, PDE4A
25	cellulose acetate32	9.5	CFB, HP, G6PD
26	n5-(1-iminoethyl)-l-ornithine32	9.4	NOS3, NOS2
27	l-thiocitrulline32 9 9	11.2	NOS2, NOS3
28	pge132	9.1	ADORA2B, PDE5A, F5, PDE4A
29	ng-nitro-l-arginine32	9.1	NOS3, NOS2, PDE4A
30	vitamin-e32	9.1	F5, G6PD, HP, PDE5A
31	sildenafil32 34 9 18 9	13.1	PDE4A, PDE5A, NOS3, NOS2
32	methylene32	9.0	G6PD, F5, PDE4A
33	glycerol32 9 18 9	11.9	AQP1, GLA, G6PD, PDE4A, NOS3
34	phospholipid32	8.6	GLA, SLC4A1, F5, HP, PDE4A, AQP1
35	lactate32	8.4	F5, GNRH1, GLA, HP, G6PD, SLC4A1
36	creatinine32	8.4	G6PD, HP, GNRH1, GLA, F5, AQP1
37	cgmp32	8.4	PDE5A, NPR1, NOS3, NOS2, AQP1, GUCY2C
38	epinephrine32 9 18 9	11.3	F5, GNRH1, HP, G6PD, PDE4A
39	folate32	8.3	NOS3, HP, F5, SLC4A1, PDE5A, G6PD
40	prostacyclin32	8.2	NOS3, PDE5A, NOS2, F5, PDE4A
41	aspartate32	8.1	GNRH1, HP, GLA, G6PD, F5, PDE4A
42	actinomycin d32	8.1	PDE4A, GNRH1, HP, NOS2, NOS3, G6PD
43	tamoxifen32 34 9 9	11.0	G6PD, NOS3, GNRH1, F5, PDE4A
44	adenylate32	7.8	ADORA2B, G6PD, NOS2, HP, GNRH1, PDE4A
45	arginine32	7.5	F5, AQP1, NOS3, PDE4A, PDE5A, GNRH1
46	serine32	7.1	PDE4A, F5, HP, NOS3, G6PD, NPR1
47	nitric oxide32 9 18 9	10.0	AQP1, HP, NOS2, F5, PDE5A, NPR1
48	estrogen32	7.0	HP, NPR1, G6PD, PDE5A, NOS3, F13A1
49	vegf32	6.8	KL, PDE5A, NOS3, NOS2, HP, F5
50	calcium32 9 18 9	9.1	AQP1, KL, ITGAV, F5, F13A1, GLA

Cellular components related to priapism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	8.8	KL, ITGAV, AQP1, TGFBR3, NPR1, SLC4A1

Biological processes related to priapism according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cGMP biosynthetic process	GO:030828	10.1	NPR1, ADORA2B
2	receptor guanylyl cyclase signaling pathway	GO:007168	10.0	GUCY2C, NPR1
3	cGMP biosynthetic process	GO:006182	9.9	NPR1, AQP1
4	positive regulation of guanylate cyclase activity	GO:031284	9.8	NOS3, ADORA2B
5	arginine catabolic process	GO:006527	9.4	NOS2, NOS3
6	regulation of blood vessel size	GO:050880	9.3	NOS3, NPR1
7	response to hypoxia	GO:001666	9.0	TGFBR3, PDE5A, NOS3, NOS2
8	blood coagulation	GO:007596	7.8	ITGAV, PDE5A, NOS3, NOS2, F13A1, F5

Molecular functions related to priapism according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	guanylate cyclase activity	GO:004383	10.0	GUCY2C, NPR1
2	nitric-oxide synthase activity	GO:004517	9.4	NOS2, NOS3
3	tetrahydrobiopterin binding	GO:034617	9.3	NOS2, NOS3
4	arginine binding	GO:034618	9.0	NOS2, NOS3
5	NADP binding	GO:050661	8.8	G6PD, NOS3, NOS2