MCID: PRP007
MIFTS: 52

Priapism malady

Reproductive, Genetic categories

Summaries for Priapism

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Priapism (/ˈpraɪəpɪzəm/) is a potentially painful medical condition in which the erect penis does... more...

MalaCards: Priapism, also known as priapism, familial idiopathic, is related to sickle cell disease and sickle cell anemia. An important gene associated with Priapism is GLA (galactosidase, alpha), and among its related pathways are O2/CO2 exchange in erythrocytes and Common Pathway. The compounds hg2+ and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and smooth muscle, and related mouse phenotypes are reproductive system and liver/biliary system.

Aliases & Classifications for Priapism

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Reproductive


Aliases & Descriptions:

priapism 8 43 10 45 61
priapism, familial idiopathic 43 61
familial idiopathic priapism 43
mentulagra 8


External Ids:

Disease Ontology8 DOID:9286
ICD9CM27 607.3
MeSH35 D011317
NCIt40 C85022
ICD1025 N48.3

Related Diseases for Priapism

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Priapism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease30.8G6PD, GLA, HP, NOS3
2sickle cell anemia30.6HP, G6PD
3adenocarcinoma30.3NPR1, GUCY2C, F13A1, AQP1
4fabry disease30.1GLA
5thalassemia30.1G6PD, SLC4A1
6premature ejaculation29.8PDE5A
7hereditary spherocytosis29.8SLC4A1, G6PD
8antiphospholipid syndrome29.8F5
9polycystic kidney disease, autosomal dominant29.8AQP1, NOS3, SLC4A1
10thromboembolism29.8NOS3, F5, G6PD
11spinal cord injury10.2
12chronic myeloid leukemia10.2
13protein s deficiency10.1
14protein c deficiency10.1
15low-flow priapism10.1
16beta thalassemia10.0
17paraphimosis10.0
18cocaine abuse10.0
19systemic scleroderma10.0
20venous thrombosis10.0
21ischemic optic neuropathy10.0PDE5A
22hyperparathyroidism10.0KL
23prostatitis10.0PDE5A
24peritonitis10.0AQP1
25vascular disease10.0HP
26hepatitis b10.0CFB
27age related macular degeneration10.0CFB
28leukemia10.0HP
29pulmonary emphysema10.0KL
30arthritis10.0HP
31colon cancer10.0GUCY2C
32varicocele10.0GNRH1
33blackwater fever10.0G6PD
34polycystic ovary syndrome10.0GNRH1
35infertility10.0GNRH1
36migraine10.0PDE5A
37nephrotic syndrome10.0HP
38cerebrovascular disease10.0F13A1
39pancreatic cancer10.0HP
40hepatitis10.0CFB, HP
41sarcoma10.0F13A1
42pneumonia10.0PDE4A
43hypogonadism10.0PDE5A, GNRH1
44autoimmune hemolytic anemia10.0HP, G6PD
45nephritis10.0CFB
46sexual disorder10.0PDE5A, GNRH1
47congenital hemolytic anemia10.0G6PD, HP
48ovarian cancer10.0HP, GNRH1
49hereditary elliptocytosis10.0G6PD, SLC4A1
50diarrhea10.0GUCY2C, NPR1

Graphical network of the top 20 diseases related to Priapism:



Diseases related to priapism

Clinical Features for Priapism

Drugs & Therapeutics for Priapism

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Priapism

Drug clinical trials:

Search ClinicalTrials for Priapism

Search NIH Clinical Center for Priapism

Search CenterWatch for Priapism

Genetic Tests for Priapism

Anatomical Context for Priapism

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Priapism:

33
Brain, Spinal cord, Smooth muscle, Kidney, Skin, Prostate, Myeloid, T cells

Animal Models for Priapism or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Priapism

Sources:
51PubMed
See all sources

Articles related to Priapism:

(show top 50)    (show all 514)
idTitleAuthorsYear
1
Unsatisfactory outcomes of prolonged ischemic priapism without early surgical shunts: our clinical experience and a review of the literature. (22922321)
2013
2
Corporal Burnett "Snake" surgical maneuver for the treatment of ischemic priapism: long-term followup. (23017524)
2013
3
Salvage management of prolonged ischemic priapism: Al-Ghorab shunt plus cavernous tunneling with blunt cavernosotomy. (23088606)
2013
4
Incidence of priapism in emergency departments in the United States. (23583536)
2013
5
Algorithm for initial management of priapism in chronic myeloid leukaemia. (22924590)
2012
6
Priapism in teenage boys following depot testosterone. (23329767)
2012
7
Surgical management of ischemic priapism. (22221308)
2012
8
Priapism secondary to involvement of corpora cavernosa by locally advanced prostate cancer. (22585653)
2012
9
Priapism as the initial manifestation of a penile and lower limb cutaneous metastasis of prostate adenocarcinoma with low serum PSA level. (22700763)
2012
10
Sibutramine for the treatment of recurrent high-flow priapism. (21979300)
2012
11
Medical management of ischemic stuttering priapism: a contemporary review of the literature. (22057380)
2012
12
Priapism in sickle cell anemia: emerging mechanistic understanding and better preventative strategies. (21490762)
2011
13
A case of recurrent priapism in the context of quetiapine use, discontinuation, and rechallenge. (21364331)
2011
14
Posttraumatic high-flow priapism in children treated with autologous blood clot embolization: long-term results and review of the literature. (21127852)
2011
15
An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. (20112132)
2010
16
The actual incidence of papaverine-induced priapism in patients with erectile dysfunction following penile colour Doppler ultrasonography. (20078509)
2010
17
T-shaped shunt and intracavernous tunneling for prolonged ischemic priapism. (19233430)
2009
18
Priapism as a manifestation of tetania. (18991191)
2009
19
Investigating the effects of high-dose phenylephrine in the management of prolonged ischaemic priapism. (18466270)
2008
20
Sickle cell trait and priapism: a case report and review of the literature. (19116025)
2008
21
Treatment of idiopathic recurrent priapism with fluoxetine and low dose Perphenazine. (18517121)
2008
22
Recurrent priapism in sickle cell trait with protein S deficiency. (19157328)
2008
23
Conservative management of priapism secondary to leukemia. (18506758)
2008
24
T-shunt with or without tunnelling for prolonged ischaemic priapism. (19035864)
2008
25
Association between priapism and concurrent use of risperidone and Ginkgo biloba. (17908535)
2007
26
Long standing priapism as presentation of lymphoma. (17078020)
2007
27
Priapism--a rare complication following continuous epidural morphine and bupivacaine infusion. (17876369)
2007
28
Pathology of "Berkeley" sickle-cell mice includes gallstones and priapism. (16597602)
2006
29
Ziprasidone-induced priapism requiring surgical treatment. (16356688)
2006
30
Tardive priapism associated with clozapine. A case report. (16944414)
2006
31
Medical and surgical management of priapism. (16461470)
2006
32
Propofol-induced priapism, a case confirmed with rechallenge. (16638914)
2006
33
Priapism and activated protein C resistance]. (15999622)
2005
34
High flow priapism secondary to internal urethrotomy treated with embolization. (15017242)
2004
35
Sexual function after highly selective embolization of cavernous artery in patients with high flow priapism: long-term followup. (15247752)
2004
36
Priapism. (16422992)
2004
37
Priapism. (15679220)
2004
38
Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol. (15703094)
2004
39
Cocaine and ephedrine-induced priapism: case reports and investigation of potential adrenergic mechanisms. (12837464)
2003
40
A case of risperidone-induced priapism. (12716256)
2003
41
Priapism--a rare presentation in chronic myeloid leukemia: case report and review of the literature. (12846529)
2003
42
The management of low-flow priapism with the immediate insertion of a penile prosthesis. (12460352)
2002
43
Priapism in a 15-year-old boy with congenital dyserythropoietic anemia type II (hereditary erythroblastic multinuclearity with positive acidified serum lysis test). (11743348)
2002
44
Priapism associated with trazodone in an adolescent with autism. (12108798)
2002
45
Short period of administration of diethylstilbestrol in stuttering priapism in sickle cell anemia. (11921029)
2002
46
Successful treatment of low-flow priapism associated with phenothiazine therapy. (11683975)
2001
47
Theriogenology question of the month. Priapism or paraphimosis. (10340072)
1999
48
Priapism associated with chronic cocaine abuse. (8042894)
1994
49
Priapism and Fabry disease: a case report. (2161340)
1990
50
Priapism with hyperacute stem-cell leukemia. (4522659)
1974

Genetic Variations for Priapism

Expression for genes affiliated with Priapism

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for genes affiliated with Priapism

Sources:
54Reactome, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Priapism

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Priapism according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1hg2+4510.4AQP1, GLA
2estrogen4510.2F13A1, PDE5A
3cellulose acetate4510.1G6PD, HP, CFB
4lactose45 1110.9HP, GLA, G6PD
5urea45 11 2411.8F5, F13A1, HP, AQP1
6nitroglycerin45 1110.8NOS3, NPR1, PDE5A
7raloxifene45 29 50 1112.7GNRH1, F5, NOS3
8forskolin45 50 1111.7PDE5A, NPR1, ADORA2B
9vitamin-e459.6HP, F5, G6PD, PDE5A
10kininogen459.6HP, F13A1, F5
11motapizone459.6PDE4A, PDE5A
12glutamate459.6GNRH1, NPR1, GLA, SLC4A1, ADORA2B
13citrate459.5G6PD, F5, HP, SLC4A1, NOS3
14roflumilast45 1110.5PDE4A, PDE5A
15tamoxifen45 50 29 1112.5G6PD, PDE4A, GNRH1
16chloride459.5GUCY2C, SLC4A1, ADORA2B, AQP1
17enprofylline45 1110.5PDE4A, ADORA2B
18methylene459.4PDE4A, G6PD, F5
198-bromo cgmp459.4PDE4A, PDE5A, NPR1
20lactate459.4GNRH1, G6PD, F5, GLA, HP, SLC4A1
21vinpocetine45 2910.4PDE5A, PDE4A
22creatinine459.4GNRH1, G6PD, F5, GLA, HP, AQP1
23erythro-9-(2 hydroxy 3-nonyl)adenine459.4PDE5A, PDE4A
24aspartate459.3GLA, G6PD, PDE4A, GNRH1
25papaverine45 2 1111.3NOS3, PDE5A, PDE4A
26sildenafil45 50 29 11 2413.2PDE4A, PDE5A, NOS3
27serine459.2PDE4A, NPR1, G6PD, GLA, HP
28pentoxifylline45 1110.2GNRH1, PDE4A, PDE5A, HP
29glucose459.2AQP1, SLC4A1, CFB, GLA, PDE4A
30sodium45 2410.1PDE5A, NPR1, HP, SLC4A1, AQP1
31folate459.1PDE5A, G6PD, F5, HP, SLC4A1, NOS3
32glycerol45 11 2411.1PDE4A, G6PD, GLA, NOS3, AQP1
33epinephrine45 11 2411.0GNRH1, PDE4A, G6PD, F5, HP
34phospholipid458.9PDE4A, F5, GLA, HP, SLC4A1, AQP1
35hydrogen45 249.9AQP1, SLC4A1, GLA, PDE5A, PDE4A
36actinomycin d458.9GNRH1, PDE4A, G6PD, HP, NOS3
37pge1458.9ADORA2B, F5, PDE5A, PDE4A
38guanylate458.8PDE4A, PDE5A, NPR1, GUCY2C, NOS3
39xanthine45 249.8PDE4A, NOS3, ADORA2B
40prostacyclin458.8NOS3, F5, PDE5A, PDE4A
41alanine458.7GNRH1, NPR1, F5, HP, SLC4A1, AQP1
42cgmp45 299.7PDE4A, PDE5A, NPR1, GUCY2C, NOS3, AQP1
43aspirin45 50 29 2411.6PDE4A, G6PD, F5, F13A1, HP, NOS3
44glutamine458.6PDE4A, PDE5A, G6PD, F5, F13A1
45atp45 299.5PDE4A, NPR1, G6PD, GUCY2C, BLM, HP
46sodium nitroprusside458.4AQP1, GNRH1, PDE4A, PDE5A, NPR1, G6PD
47arginine458.3GNRH1, PDE4A, PDE5A, F5, GLA, NOS3
48nitric oxide45 11 2410.0PDE4A, PDE5A, NPR1, F5, GLA, HP
49vegf457.5KL, PDE4A, PDE5A, ITGAV, F5, F13A1
50calcium45 50 11 249.6KL, PDE4A, PDE5A, GUCY2C, ITGAV, F5

GO Terms for genes affiliated with Priapism

Sources:
16Gene Ontology
See all sources

Cellular components related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8GNRH1, F5, F13A1, GLA, HP, CFB
2integral to plasma membraneGO:0058878.0TGFBR3, KL, NPR1, ITGAV, SLC4A1, ADORA2B

Biological processes related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cGMP biosynthetic processGO:00618210.0AQP1, NPR1
2regulation of blood vessel sizeGO:0508809.9NOS3, NPR1
3positive regulation of cGMP biosynthetic processGO:0308289.8NPR1, ADORA2B
4positive regulation of guanylate cyclase activityGO:0312849.8ADORA2B, NOS3
5receptor guanylyl cyclase signaling pathwayGO:0071689.7GUCY2C, NPR1
6blood coagulationGO:0075968.5NOS3, F13A1, F5, ITGAV, PDE5A

Molecular functions related to Priapism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanylate cyclase activityGO:0043839.9GUCY2C, NPR1
2transforming growth factor beta bindingGO:0504319.3TGFBR3, ITGAV
3protein bindingGO:0055156.4G6PD, GUCY2C, ITGAV, F5, BLM, GLA

Products for genes affiliated with Priapism

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Priapism

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet