MCID: PRP007
MIFTS: 51

Priapism malady

Genetic diseases, Rare diseases, Reproductive diseases categories

Summaries for Priapism

About this section


Wikipedia:63 Priapism (/?pra??p?z?m/) is a potentially painful medical condition in which the erect penis does not... more...

MalaCards based summary: Priapism, also known as priapism, familial idiopathic, is related to sickle cell anemia and sickle cell disease. An important gene associated with Priapism is GLA (galactosidase, alpha), and among its related pathways are O2/CO2 exchange in erythrocytes and Effects of nitric oxide. The compounds hg2+ and lactose have been mentioned in the context of this disorder. Affiliated tissues include myeloid, prostate and spinal cord, and related mouse phenotypes are digestive/alimentary and respiratory system.

Disease Ontology:9 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

Aliases & Classifications for Priapism

About this section

Priapism, Aliases & Descriptions:

Name: Priapism 9 41 11 43 60
Priapism, Familial Idiopathic 41 60
 
Familial Idiopathic Priapism 41
Mentulagra 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:9286
ICD9CM27 607.3
MeSH33 D011317
NCIt38 C85022
ICD1025 N48.3

Related Diseases for Priapism

About this section

Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1sickle cell anemia31.2HP, G6PD
2sickle cell disease31.0G6PD, HP, GLA, NOS3
3glucose-6-phosphate dehydrogenase deficiency30.8G6PD, HP
4peyronie's disease30.7PDE5A
5thalassemia30.6G6PD, SLC4A1
6hemoglobinopathy30.4G6PD, HP
7hereditary spherocytosis30.3G6PD, SLC4A1
8impotence30.1PDE5A, NOS2, NOS3
9kidney disease30.0NOS3, KL, HP, AQP1
10pulmonary hypertension29.8PDE5A, NOS2, NOS3
11stuttering10.6
12low-flow priapism10.6
13blood group incompatibility10.5G6PD
14blackwater fever10.5G6PD
15mediterranean spotted fever10.5G6PD
16kernicterus10.5G6PD
17leukemia10.4
18sexual disorder10.4PDE5A, GNRH1
19acute chest syndrome10.4NOS3
20congenital hemolytic anemia10.4G6PD, HP
21favism10.4G6PD, HP
22glucosephosphate dehydrogenase deficiency10.4G6PD, HP
23hemoglobinuria10.4HP, G6PD
24central retinal vein occlusion10.3F5
25hereditary elliptocytosis10.3SLC4A1, G6PD
26placental abruption10.3F5
27factor vii deficiency10.3F5
28prostatitis10.3
29methemoglobinemia10.3G6PD, HP
30autoimmune hemolytic anemia10.3G6PD, HP
31paroxysmal nocturnal hemoglobinuria10.3HP, G6PD
32bilirubin metabolic disorder10.3G6PD, HP
33nonarteritic anterior ischemic optic neuropathy10.3PDE5A, F5
34congenital heart disease10.3HP, PDE5A, GLA
35spinal cord injury10.3
36myeloid leukemia10.3
37hemolytic anemia10.2G6PD, HP, SLC4A1
38arteriosclerosis10.2NOS3
39malaria10.2SLC4A1, HP, G6PD
40schizophrenia10.2
41prostate cancer10.2
42adenocarcinoma10.2
43purpura10.2
44hellp syndrome10.2HP, F5
45coronary artery disease10.2NOS3, PDE5A, HP
46factor xiii deficiency10.2F13A1, F5
47primary hyperoxaluria10.2GLA, HP, G6PD
48ovarian hyperstimulation syndrome10.2F5, GNRH1
49dysfibrinogenemia10.2F13A1, F5
50polycystic kidney disease, autosomal dominant10.2SLC4A1, NOS3, AQP1

Graphical network of the top 20 diseases related to Priapism:



Diseases related to priapism

Symptoms for Priapism

About this section

Drugs & Therapeutics for Priapism

About this section

Drug clinical trials:

Search ClinicalTrials for Priapism

Search NIH Clinical Center for Priapism

Genetic Tests for Priapism

About this section

Anatomical Context for Priapism

About this section

MalaCards organs/tissues related to Priapism:

31
Myeloid, Prostate, Spinal cord, Smooth muscle, Skin, Brain, Kidney, Testes, T cells

Animal Models for Priapism or affiliated genes

About this section

Publications for Priapism

About this section

Articles related to Priapism:

(show top 50)    (show all 546)
idTitleAuthorsYear
1
Management of priapism in adult men. (25785343)
2015
2
Acute scrotal pain and priapism: an early sign of progression in metastatic renal cell carcinoma? (25694639)
2015
3
How I treat priapism. (25810489)
2015
4
Molecular Pathophysiology of Priapism: Emerging Targets. (25392014)
2014
5
Malignant priapism secondary to isolated penile metastasis from a renal pelvic carcinoma. (25210564)
2014
6
A Case of Painless Pediatric Priapism and Cough. (25285386)
2014
7
Sustained nitric oxide (NO)-releasing compound reverses dysregulated NO signal transduction in priapism. (24076963)
2014
8
Priapism Induced by Boceprevir-CYP3A4 Inhibition and I+-Adrenergic Blockade: Case Report. (24092799)
2014
9
18F-FDG PET/CT in a case of malignant priapism secondary to metastasis from mucoid adenocarcinoma of the cecum. (23334147)
2013
10
Unsatisfactory outcomes of prolonged ischemic priapism without early surgical shunts: our clinical experience and a review of the literature. (22922321)
2013
11
Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress. (23844149)
2013
12
Priapism in children: a comprehensive review and clinical guideline. (24135215)
2013
13
Castration for treating recurrent priapism: can we do better? (21799141)
2012
14
Priapism: comorbid factors and treatment outcomes in a contemporary series. (22811705)
2012
15
The use of sudafed for priapism in pediatric patients with sickle cell disease. (22041221)
2012
16
High-flow priapism due to a malignant glomus tumor (glomangiosarcoma) of the corpus cavernosum. (19912496)
2011
17
Treating stuttering priapism. (21914108)
2011
18
Early insertion of inflatable prosthesis for intractable ischemic priapism: our experience and review of the literature. (21654814)
2011
19
Daily phosphodiesterase type 5 inhibitor therapy as rescue for recurrent ischemic priapism after failed androgen ablation. (21127306)
2011
20
A crackling priapism related to Fournier's gangrene in a patient on chronic peritoneal dialysis. (20600298)
2010
21
Favorable response to intrathecal, but not oral, baclofen of priapism in a patient with spinal cord injury. (19179913)
2009
22
Posttraumatic high-flow priapism: case report, current management options and literature review. (19623873)
2009
23
Investigating the effects of high-dose phenylephrine in the management of prolonged ischaemic priapism. (18466270)
2008
24
Posttraumatic nonischemic priapism treated with autologous blood clot embolization. (18173765)
2008
25
Sickle cell trait and priapism: a case report and review of the literature. (19116025)
2008
26
Glucose-6-phosphate dehydrogenase deficiency associated stuttering priapism: report of a case. (18823322)
2008
27
Sickle cell disease status and outcomes of African-American men presenting with priapism. (18312286)
2008
28
Superselective arterial embolization for patients with high-flow priapism: results of follow-up for five or more years. (17453510)
2007
29
Association between priapism and concurrent use of risperidone and Ginkgo biloba. (17908535)
2007
30
Priapism in the oncology setting. (17441393)
2007
31
The Winter procedure as management for prolonged low-flow priapism: a case report. (18055300)
2007
32
Stuttering priapism after ingestion of alfuzosin. (17070382)
2006
33
High-flow priapism as a complication of a veno-occlusive priapism: two case reports. (16224494)
2006
34
Is the combination of superselective transcatheter autologous clot embolization and duplex sonography-guided compression therapy useful treatment option for the patients with high-flow priapism? (16079900)
2006
35
Distal cavernosum-glans shunts for ischemic priapism. (16839333)
2006
36
Irreversible priapism during olanzapine and lithium therapy. (15144518)
2004
37
Priapism following ingestion of tamsulosin. (12771780)
2003
38
Priapism secondary to hypertriglyceridemia. (12576856)
2003
39
Evidence-based radiology problems. High-flow post-traumatic priapism: transcatheter embolotherapy: October 2003-September 2004. (14593770)
2003
40
The incidence and management of priapism in Western Australia: a 16 year audit. (12934055)
2003
41
Priapism associated with two atypical antipsychotic agents. (12173794)
2002
42
Management strategy for arterial priapism: therapeutic dilemmas. (12394712)
2002
43
Interventional treatment of traumatic priapism. (12431145)
2002
44
The management of low-flow priapism with the immediate insertion of a penile prosthesis. (12460352)
2002
45
Unusual complications of warfarin therapy: skin necrosis and priapism. (10931425)
2000
46
Re: Chronic myeloid leukaemia presenting as priapism in children: need for multidisciplinary approach. (12862132)
2000
47
Priapism in a patient with protein C deficiency. (9352148)
1997
48
Permanent open shunt as a reason for impotence or reduced potency after surgical treatment of priapism in 26 patients. (8750051)
1995
49
Priapism associated with chronic cocaine abuse. (8042894)
1994
50
Priapism associated with intranasal cocaine abuse. (2304177)
1990

Variations for Priapism

About this section

Expression for genes affiliated with Priapism

About this section
Search GEO for disease gene expression data for Priapism.

Pathways for genes affiliated with Priapism

About this section

Pathways related to Priapism according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9AQP1, SLC4A1
2
Show member pathways
Quercetin and Nf-kB/ AP-1 induced cell apoptosis36
9.5NOS3, NOS2
39.5NOS3, NOS2
4
Show member pathways
9.5NOS3, NOS2
5
Show member pathways
9.1NOS3, ITGAV, TGFBR3
69.1TGFBR3, NOS3, ITGAV
7
Show member pathways
8.9NOS3, NOS2, PDE5A
88.9NOS3, NOS2, PDE5A
9
Show member pathways
8.9NOS3, PDE5A, NOS2
10
Show member pathways
8.7NOS3, ITGAV, GNRH1, TGFBR3
118.7ADORA2B, NOS2, NOS3
12
Show member pathways
Development EDNRB signaling58
Development ACM2 and ACM4 activation of ERK58
Cell adhesion Integrin inside out signaling58
Development G Proteins mediated regulation MARK ERK signaling58
Signal transduction IP3 signaling58
Development Angiotensin signaling via PYK258
Development EPO induced MAPK pathway58
8.6ADORA2B, ITGAV, NOS3
13
Show member pathways
8.2NOS3, NOS2, GLA, KL, G6PD, AQP1
14
Show member pathways
7.6F5, F13A1, ITGAV, PDE5A, NOS2, NOS3

Compounds for genes affiliated with Priapism

About this section

Compounds related to Priapism according to GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idCompoundScoreTop Affiliating Genes
1hg2+4310.3AQP1, GLA
2lactose43 1210.9HP, GLA, G6PD
3magnesium lithospermate b439.9NOS2, NOS3
4l-thiocitrulline43 1210.9NOS2, NOS3
5s-ethylisothiourea43 1210.9NOS2, NOS3
6n5-(1-iminoethyl)-l-ornithine439.8NOS2, NOS3
7nitrit439.8NOS2, NOS3
8n-(3-(aminomethyl)benzyl)acetamidine43 1210.8NOS2, NOS3
9n(g)-hydroxy-l-arginine439.8NOS3, NOS2
103-bromo-7-nitroindazole59 1210.8NOS2, NOS3
117-nitroindazole43 1210.8NOS3, NOS2
12kininogen439.7F13A1, HP, F5
13vitamin b12439.6HP, G6PD, F5
14malondialdehyde439.6F5, G6PD, HP
15urea43 24 1211.6F5, HP, AQP1, F13A1
16glycerol43 24 1211.6G6PD, NOS3, AQP1, GLA
17raloxifene43 49 28 1212.5NOS3, GNRH1, F5
18pentoxifylline43 1210.5GNRH1, HP, PDE5A
19diphenyleneiodonium439.5NOS2, G6PD, NOS3
20phospholipid439.4F5, GLA, AQP1, SLC4A1, HP
21epinephrine43 24 1211.4GNRH1, G6PD, F5, HP
22n(g),n(g)-dimethylarginine439.4NOS3, NOS2
23aspartate439.3F5, G6PD, HP, GLA, GNRH1
24vitamin-e439.3G6PD, PDE5A, F5, HP
25kt 582343 2810.3PDE5A, NOS2, NOS3
26sildenafil28 43 49 24 1213.3NOS3, PDE5A, NOS2
27nitroglycerin43 1210.2NOS3, PDE5A, NOS2
28peroxynitrite439.2SLC4A1, NOS2, NOS3
29nitrate439.2PDE5A, NOS3, NOS2
30citrate439.1SLC4A1, NOS3, F5, HP, G6PD
31creatinine439.1GLA, F5, HP, G6PD, GNRH1, AQP1
32lactate439.1GLA, F5, HP, G6PD, GNRH1, SLC4A1
33aspirin43 49 28 2412.1HP, F13A1, G6PD, NOS3, F5
34cgmp43 2810.0NOS2, NOS3, AQP1, PDE5A
35actinomycin d439.0NOS2, NOS3, GNRH1, HP, G6PD
36tamoxifen43 49 28 1212.0F5, GNRH1, G6PD, NOS3
37ascorbic acid43 249.9NOS3, NOS2, F5, G6PD, HP
38prostacyclin438.9NOS3, F5, PDE5A, NOS2
39testosterone43 59 24 1211.7GNRH1, G6PD, HP, PDE5A, F5
40fibrinogen438.6ITGAV, F5, HP, F13A1
41adenylate438.6NOS2, HP, ADORA2B, GNRH1, G6PD
42pge1438.6F5, PDE5A, ADORA2B
43folate438.5PDE5A, G6PD, SLC4A1, NOS3, HP, F5
44sodium nitroprusside438.4GNRH1, AQP1, PDE5A, NOS2, NOS3, G6PD
45arginine438.1GNRH1, NOS3, NOS2, GLA, PDE5A, F5
46nitric oxide43 24 129.9GLA, NOS2, NOS3, PDE5A, HP, AQP1
47estrogen437.7NOS2, F5, PDE5A, HP, G6PD, F13A1
48glutamate437.6NOS2, NOS3, SLC4A1, F5, HP, ADORA2B
49vegf437.3NOS3, F13A1, AQP1, ITGAV, HP, PDE5A
50calcium43 49 24 129.2AQP1, F13A1, ADORA2B, ITGAV, NOS3, NOS2

GO Terms for genes affiliated with Priapism

About this section

Cellular components related to Priapism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cortical cytoskeletonGO:00308639.7NOS2, SLC4A1
2blood microparticleGO:00725629.5HP, SLC4A1, F13A1
3extracellular regionGO:00055768.7GLA, F13A1, KL, F5, HP, GNRH1
4extracellular spaceGO:00056158.6KL, F5, HP, TGFBR3, GNRH1
5extracellular vesicular exosomeGO:00700628.3SLC4A1, TGFBR3, AQP1, G6PD, ITGAV, HP
6integral component of plasma membraneGO:00058878.0KL, SLC4A1, AQP1, TGFBR3, ADORA2B, ITGAV

Biological processes related to Priapism according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1bicarbonate transportGO:00157019.8SLC4A1, AQP1
2arginine catabolic processGO:00065279.7NOS3, NOS2
3nitric oxide biosynthetic processGO:00068099.6NOS3, NOS2
4nitric oxide mediated signal transductionGO:00072639.6NOS2, NOS3
5negative regulation of blood pressureGO:00457769.6NOS3, NOS2
6positive regulation of vasodilationGO:00459099.5NOS3, NOS2
7interaction with hostGO:00517019.2NOS2, NOS3
8positive regulation of guanylate cyclase activityGO:00312848.9NOS3, NOS2, ADORA2B
9small molecule metabolic processGO:00442818.9SLC4A1, NOS3, GLA, G6PD, AQP1
10blood coagulationGO:00075967.8F13A1, ITGAV, PDE5A, F5, NOS2, NOS3

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1nitric-oxide synthase activityGO:00045179.7NOS3, NOS2
2arginine bindingGO:00346189.7NOS2, NOS3
3tetrahydrobiopterin bindingGO:00346179.6NOS2, NOS3
4NADPH-hemoprotein reductase activityGO:00039589.6NOS3, NOS2
5transforming growth factor beta bindingGO:00504319.6TGFBR3, ITGAV
6fibroblast growth factor bindingGO:00171349.6KL, TGFBR3
7NADP bindingGO:00506619.4NOS3, NOS2, G6PD
8FMN bindingGO:00101819.4NOS2, NOS3
9protein homodimerization activityGO:00428039.2SLC4A1, NOS2, GLA, G6PD
10protein bindingGO:00055156.9TGFBR3, AQP1, G6PD, ITGAV, HP, F5

Products for genes affiliated with Priapism

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Priapism

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet