MCID: PRP007
MIFTS: 46

Priapism malady

Categories: Rare diseases, Reproductive diseases, Cardiovascular diseases, Genetic diseases

Aliases & Classifications for Priapism

Aliases & Descriptions for Priapism:

Name: Priapism 12 50 52 42 14 69
Priapism, Familial Idiopathic 50 69
Familial Idiopathic Priapism 50
Mentulagra 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9286
ICD10 33 N48.3 N48.30
ICD9CM 35 607.3
MeSH 42 D011317
NCIt 47 C85022
UMLS 69 C0033117

Summaries for Priapism

Disease Ontology : 12 A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain.

MalaCards based summary : Priapism, also known as priapism, familial idiopathic, is related to low-flow priapism and persistent genital arousal disorder, and has symptoms including painful erection An important gene associated with Priapism is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Apoptosis Pathway. The drugs Prazosin and Adrenergic Agents have been mentioned in the context of this disorder. Affiliated tissues include myeloid, prostate and spinal cord, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Priapism is a condition in which a penis remains erect for hours in the absence of stimulation or after... more...

Related Diseases for Priapism

Diseases related to Priapism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
id Related Disease Score Top Affiliating Genes
1 low-flow priapism 12.1
2 persistent genital arousal disorder 11.2
3 sickle cell disease 10.2
4 stuttering 10.2
5 kartagener syndrome 10.2 NOS3 PDE5A
6 rapidly progressive glomerulonephritis 10.2 NOS3 PDE5A
7 traumatic glaucoma 10.1 NOS3 PDE5A
8 inherited blood coagulation disease 10.1 F13A1 F5
9 aphasia 10.1 NOS3 PDE5A
10 eagle syndrome 10.1 F13A1 F5
11 alpha-2-plasmin inhibitor deficiency 10.1 NOS3 PDE5A
12 immunodeficiency, common variable, 6 10.0 F13A1 F5
13 villous adenoma 10.0 F5 NOS3 PDE5A
14 sickle cell anemia 10.0
15 leukemia 10.0
16 prostatitis 10.0
17 viral hepatitis 10.0 NOS3 PDE5A
18 myeloid leukemia 9.9
19 thrombosis 9.9
20 adenocarcinoma 9.9
21 uterine corpus cancer 9.9 AQP1 F5
22 myocardial infarction 9.8 F13A1 F5 NOS3 PDE5A
23 schizophrenia 9.8
24 spinal cord injury 9.8
25 prostate cancer 9.8
26 thalassemia 9.8
27 purpura 9.8
28 prostate adenocarcinoma 9.7
29 protein c deficiency 9.7
30 fabry disease 9.6
31 lymphoma 9.6
32 impotence 9.6
33 protein s deficiency 9.6
34 paraphimosis 9.6
35 cocaine abuse 9.6
36 peritonitis 9.6
37 thalassemia intermedia 9.6
38 systemic lupus erythematosus 9.5
39 esophageal cancer 9.5
40 renal cell carcinoma 9.5
41 chordoma 9.5
42 multiple myeloma 9.5
43 hypertriglyceridemia 9.5
44 pick disease 9.5
45 peyronie's disease 9.5
46 pulmonary hypertension 9.5
47 brain injury 9.5
48 chronic lymphocytic leukemia 9.5
49 niemann-pick disease 9.5
50 spinal stenosis 9.5

Graphical network of the top 20 diseases related to Priapism:



Diseases related to Priapism

Symptoms & Phenotypes for Priapism

UMLS symptoms related to Priapism:


painful erection

MGI Mouse Phenotypes related to Priapism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 AQP1 F13A1 F5 ITGAV KL NOS3
2 hematopoietic system MP:0005397 9.87 AQP1 F13A1 ITGAV KL NOS3 SLC4A1
3 homeostasis/metabolism MP:0005376 9.8 AQP1 F13A1 F5 ITGAV KL NOS3
4 mortality/aging MP:0010768 9.76 AQP1 F13A1 F5 ITGAV KL NOS3
5 muscle MP:0005369 9.35 ITGAV KL NOS3 SLC4A1 TGFBR3
6 renal/urinary system MP:0005367 9.02 AQP1 ITGAV KL NOS3 SLC4A1

Drugs & Therapeutics for Priapism

Drugs for Priapism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prazosin Approved Phase 3 19216-56-9 4893
2 Adrenergic Agents Phase 3
3 Adrenergic Antagonists Phase 3
4 Adrenergic alpha-1 Receptor Antagonists Phase 3
5 Adrenergic alpha-Antagonists Phase 3
6 Neurotransmitter Agents Phase 3
7 Antihypertensive Agents Phase 3
8
Hydroxyurea Approved Phase 2 127-07-1 3657
9 Sildenafil Citrate Phase 2 171599-83-0
10 Nucleic Acid Synthesis Inhibitors Phase 2
11 Vasodilator Agents Phase 2
12 Phosphodiesterase 5 Inhibitors Phase 2
13 Phosphodiesterase Inhibitors Phase 2
14 Immunoglobulins Phase 2
15 Antibodies, Monoclonal Phase 2
16 Antibodies Phase 2
17 Citrate Nutraceutical Phase 2
18
Citric Acid Nutraceutical, Vet_approved Phase 2 77-92-9 311

Interventional clinical trials:


id Name Status NCT ID Phase
1 AScVS and/ or Prazosin for Scorpion Envenomation Completed NCT00753064 Phase 3
2 Differential Effect of Silodosin Versus Tamsulosin on Stone Clearance After Extra-corporeal Shock Wave Lithotripsy Withdrawn NCT01560091 Phase 3
3 Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia Completed NCT00940901 Phase 2
4 Study to Assess Safety and Impact of SelG1 With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients With Pain Crises Completed NCT01895361 Phase 2
5 Tadalafil for Treatment of Priapism in Men With Sickle Cell Anemia Withdrawn NCT00538564 Phase 2
6 Priapism in Boys and Men With Sickle Cell Disease - Demographics, Characteristics and Prevalence Completed NCT00300235
7 Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events Recruiting NCT02539771
8 Heart Arteries and Sickle Cell Disease / Coeur Artères DREpanocytose Recruiting NCT03114137
9 Androgen Regulation of Priapism in Sickle Cell Disease Withdrawn NCT01940718 Early Phase 1

Search NIH Clinical Center for Priapism

Cochrane evidence based reviews: priapism

Genetic Tests for Priapism

Anatomical Context for Priapism

MalaCards organs/tissues related to Priapism:

39
Myeloid, Prostate, Spinal Cord, Smooth Muscle, Skin, Brain, Tongue

Publications for Priapism

Articles related to Priapism:

(show top 50) (show all 618)
id Title Authors Year
1
Priapism in the Newborn: Shall We Intervene? ( 28083497 )
2017
2
Emergency Department Management Of Priapism. ( 28027457 )
2017
3
Guideline of guidelines: priapism. ( 27860090 )
2017
4
Clinical Management of Priapism: A Review. ( 27169123 )
2016
5
Use of High-Dose Phenylephrine in the Treatment of Ischemic Priapism: Five-Year Experience at a Single Institution. ( 27692841 )
2016
6
Poster 321 Trazodone Associated Clitoral Priapism in a Transgender Man following Traumatic Brain Injury: A Case Report. ( 27673077 )
2016
7
Risk Factors for Priapism Readmission. ( 27496074 )
2016
8
Does platelet activity play a role in the pathogenesis of idiopathic ischemic priapism? ( 27136477 )
2016
9
Beneficial effect of the nitric oxide donor compound 3-(1,3-dioxoisoindolin-2-yl)benzyl nitrate on dysregulated phosphodiesterase 5, NADPH oxidase and nitrosative stress in the sickle cell mouse penis: implication for priapism treatment. ( 27540002 )
2016
10
Priapism Associated with Homozygous Hb E State: A Causal Association or an Incidental Finding? ( 27408418 )
2016
11
Priapism - A Rare Presentation in Chronic Myeloid Leukemia: CaseA Report. ( 26793565 )
2016
12
Noninvasive treatments for iatrogenic priapism: Do they really work? A prospective multicenter study. ( 27141191 )
2016
13
The possible protective effects of dipyridamole on ischemic reperfusion injury of priapism. ( 27136481 )
2016
14
Ischemic priapism in South-East Nigeria: Presentation, management challenges, and aftermath issues. ( 26856282 )
2016
15
Risperidone-induced priapism in an autistic child: a case report. ( 27266696 )
2016
16
Priapism and glucose-6-phosphate dehydrogenase deficiency: An underestimated correlation? ( 27711102 )
2016
17
Priapism as the Presenting Complaint in Fatal Group A Streptococcal Induced Disseminated Intravascular Coagulation. ( 27989251 )
2016
18
A case of carbamazepine-induced priapism. ( 27285395 )
2016
19
Percutaneous Direct Puncture Embolization with N-butyl-cyanoacrylate for High-flow Priapism. ( 27164971 )
2016
20
Priapism as a new symptom of anaphylaxis in a prepubescent child. ( 27496320 )
2016
21
Recurring priapism may be a symptom of voiding dysfunction - case report and literature review. ( 27256196 )
2016
22
al-Ghorab Shunt for Priapism. ( 27436080 )
2016
23
Surgical Management of Stuttering Ischemic Priapism: A Case Report and Concise Clinical Review. ( 26977408 )
2016
24
Regular automated red cell exchange transfusion in the management of stuttering priapism complicating sickle cell disease. ( 27723091 )
2016
25
Nonischaemic priapism associated with selective serotonin-3 receptor antagonist. ( 27709642 )
2016
26
Homocysteinemia: A rare cause of priapism. ( 26834419 )
2016
27
Emergency Department Visits and Inpatient Admissions Associated with Priapism among Males with Sickle Cell Disease in the United States, 2006-2010. ( 27078839 )
2016
28
Correction: Emergency Department Visits and Inpatient Admissions Associated with Priapism among Males with Sickle Cell Disease in the United States, 2006-2010. ( 27557148 )
2016
29
Embolization Treatment of High-Flow Priapism. ( 27582604 )
2016
30
High Flow Priapism in a Pediatric Patient after Circumcision with Dorsal Penile Nerve Block. ( 27648333 )
2016
31
Intracavernosal metaraminol bitartrate for treatment of priapism resulting from circumcision: a case report. ( 27104124 )
2016
32
Outcome and erectile function following treatment of priapism: An institutional experience. ( 26834401 )
2016
33
Use of amisulpride in treating adolescent onset schizophrenia associated with stuttering priapism induced by multiple antipsychotics. ( 26957345 )
2016
34
Priapism and Hypersexuality Associated With Rotigotine in an Elderly Parkinsonian Patient: A Case Report. ( 27046660 )
2016
35
Malignant priapism due to penile metastases: Case series and literature review. ( 27377094 )
2016
36
Ethylene-vinyl alcohol copolymer (Onyx(Ar)) transarterial embolization for post-traumatic high-flow priapism. ( 27429919 )
2016
37
Study of priapism as a side effect of heparin therapy in deep venous thrombosis. ( 27728751 )
2016
38
T-Shaped Shunt with Intracavernosal Tunneling, for a Pediatric Case of Refractory Ischemic Priapism. ( 27693479 )
2016
39
Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength. ( 27145183 )
2016
40
Steroids, drugs and stuttering priapism; the rock-and-roll lifestyle of a 24-year-old man. ( 26822610 )
2016
41
Penile Priapism, Clitoral Priapism, and Persistent Genital Arousal Disorder: A Contemporary Review. ( 27784607 )
2015
42
Occurrence of stuttering priapism on low dose of quetiapine. ( 25855684 )
2015
43
High-Dose Loperamide Abuse Inducing Life-Threatening Cardiac Arrhythmias; Topiramate-Induced Diarrhea in a Breastfed Infant; Danazol-Induced Stevens-Johnson Syndrome; Asenapine-Induced Myasthenic Syndrome; Black Hairy Tongue Due to Linezolid; Adalimumab-Induced Priapism. ( 26405319 )
2015
44
Semi-rigid penile prosthesis as a salvage management of idiopathic ischemic stuttering priapism. ( 26380229 )
2015
45
Priapism of the Newborn - A Case Report. ( 26329967 )
2015
46
Management of priapism in adult men. ( 25785343 )
2015
47
Priapism in Homozygous Sickle Cell Disease: A 40-year Study of the Natural History. ( 26426165 )
2015
48
Acute scrotal pain and priapism: an early sign of progression in metastatic renal cell carcinoma? ( 25694639 )
2015
49
Distal corpus cavernosum fibrosis and erectile dysfunction secondary to non-ischaemic priapism. ( 26428655 )
2015
50
Persistent penile erection (priapism) associated with quetiapine and lithium. ( 25716507 )
2015

Variations for Priapism

Expression for Priapism

Search GEO for disease gene expression data for Priapism.

Pathways for Priapism

GO Terms for Priapism

Cellular components related to Priapism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.7 AQP1 F5 ITGAV KL NOS3 SLC4A1
2 integral component of plasma membrane GO:0005887 9.02 AQP1 ITGAV KL SLC4A1 TGFBR3
3 platelet alpha granule lumen GO:0031093 8.96 F13A1 F5

Biological processes related to Priapism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell growth GO:0016049 9.16 ITGAV TGFBR3
2 hemostasis GO:0007599 8.96 F13A1 F5
3 bicarbonate transport GO:0015701 8.62 AQP1 SLC4A1

Molecular functions related to Priapism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.16 ITGAV TGFBR3
2 transforming growth factor beta binding GO:0050431 8.96 ITGAV TGFBR3
3 fibroblast growth factor binding GO:0017134 8.8 ITGAV KL TGFBR3

Sources for Priapism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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