MCID: PRM024
MIFTS: 46

Primary Angle-Closure Glaucoma malady

Eye diseases category

Aliases & Classifications for Primary Angle-Closure Glaucoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 27ICD9CM, 38NCIt, 55SNOMED-CT, 25ICD10
See all sources

Primary Angle-Closure Glaucoma, Aliases & Descriptions:

Name: Primary Angle-Closure Glaucoma 9 11 43 60
Primary Angle-Closure Glaucoma, Unspecified 9
Unspecified Primary Angle-Closure Glaucoma 9
Primary Angle-Closure Glaucoma, Nos 9
 
Primary Angle-Closure Glaucoma Nos 9
Primary Angle Closure Glaucoma 9
Angle Closure Glaucoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:1405
ICD9CM27 365.2, 365.20
NCIt38 C34640
ICD1025 H40.2

Summaries for Primary Angle-Closure Glaucoma

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MalaCards based summary: Primary Angle-Closure Glaucoma, also known as primary angle-closure glaucoma, unspecified, is related to open-angle glaucoma and blindness. An important gene associated with Primary Angle-Closure Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are EPHA2 forward signaling and Development HGF signaling pathway. The drugs echothiophate iodide and methazolamide and the compounds cholestyramine and lathosterol have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and retina, and related mouse phenotypes are muscle and digestive/alimentary.

Related Diseases for Primary Angle-Closure Glaucoma

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Graphical network of the top 20 diseases related to Primary Angle-Closure Glaucoma:



Diseases related to primary angle-closure glaucoma

Symptoms for Primary Angle-Closure Glaucoma

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Drugs & Therapeutics for Primary Angle-Closure Glaucoma

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Drug clinical trials:

Search ClinicalTrials for Primary Angle-Closure Glaucoma

Search NIH Clinical Center for Primary Angle-Closure Glaucoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Primary Angle-Closure Glaucoma

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Anatomical Context for Primary Angle-Closure Glaucoma

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MalaCards organs/tissues related to Primary Angle-Closure Glaucoma:

31
Eye, Testes, Retina, Endothelial

Animal Models for Primary Angle-Closure Glaucoma or affiliated genes

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MGI Mouse Phenotypes related to Primary Angle-Closure Glaucoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.0APOE, VAV3, VAV2, LDLR, CALCRL, OPA1
2MP:00053818.0APOE, MUC5AC, VAV3, VAV2, LOXL1, CALCRL
3MP:00036317.9PRSS56, VAV3, VAV2, LDLR, NTF4, OPA1
4MP:00053917.9NOS3, CYP1B1, APOE, MYOC, PRSS56, VAV3
5MP:00053977.6APOE, VAV3, VAV2, LDLR, HGF, CALCRL
6MP:00053857.6APOE, VAV3, VAV2, LDLR, HGF, CALCRL
7MP:00053847.4LDLR, VAV2, VAV3, APOE, NTF4, HGF
8MP:00053877.3APOE, MUC5AC, VAV3, VAV2, LDLR, CALCRL
9MP:00053766.5CYP1B1, APOE, MUC5AC, VAV3, VAV2, LDLR

Publications for Primary Angle-Closure Glaucoma

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Articles related to Primary Angle-Closure Glaucoma:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
Genetic susceptibility to primary angle closure glaucoma (PACG). (23375010)
2013
2
Efficacy of prophylactic antiglaucoma and anti-inflammatory medications in canine primary angle-closure glaucoma: a multicenter retrospective study (2004-2012). (23826812)
2013
3
Evaluation of PRSS56 in Chinese subjects with high hyperopia or primary angle-closure glaucoma. (24227917)
2013
4
Cataract surgery in eyes with filtered primary angle closure glaucoma. (23825710)
2013
5
Endoscope-assisted goniosynechialysis combined with phacoemulsification and intraocular lens implantation to manage primary angle-closure glaucoma. (23638419)
2013
6
Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length. (23920366)
2013
7
Scanning electron microscopy of the trabecular meshwork: understanding the pathogenesis of primary angle closure glaucoma. (22569378)
2012
8
A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma. (22933837)
2012
9
Susceptibility to primary angle closure glaucoma in Saudi Arabia: the possible role of mitochondrial DNA ancestry informative haplogroups. (21850192)
2011
10
The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial. (21605352)
2011
11
Surgical treatment for primary angle closure-glaucoma: a Meta analysis. (22553649)
2011
12
Ultrasound biomicroscopic assessment of angle parameters in patients with primary angle closure glaucoma undergoing phacoemulsification. (21279978)
2011
13
The evaluation of the oxidative stress parameters in patients with primary angle-closure glaucoma. (22096540)
2011
14
Outcomes of primary angle closure glaucoma management. (22204235)
2011
15
Comment on Effects of phacoemulsification versus combined phacotrabeculectomy on drainage angle status in primary angle closure glaucoma. (20935531)
2010
16
Effects of phacoemulsification versus combined phaco-trabeculectomy on drainage angle status in primary angle closure glaucoma (PACG). (19373107)
2010
17
The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy. (21139981)
2010
18
Getting the red out: primary angle-closure glaucoma. (19390391)
2009
19
Recovery of corneal hysteresis after reduction of intraocular pressure in chronic primary angle-closure glaucoma. (19782799)
2009
20
Study of biometric parameters in family members of primary angle closure glaucoma patients. (17304260)
2008
21
The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas. (18223248)
2008
22
Comparing glaucomatous optic neuropathy in primary open angle and primary angle closure glaucoma eyes by scanning laser polarimetry-variable corneal compensation. (18344755)
2008
23
Primary angle-closure glaucoma. (17467540)
2007
24
Comparison of glaucomatous optic nerve damage in primary angle-closure glaucoma with and without acute attack. (16209282)
2005
25
Crossover comparison of timolol and latanoprost in chronic primary angle-closure glaucoma. (14769594)
2004
26
Entropion uveae: early sphincter atrophy, signposting primary angle closure glaucoma? (15309973)
2004
27
Systemic autonomic function in subjects with primary angle-closure glaucoma: a comparative study of symptomatic and asymptomatic disease presentation. (15068428)
2004
28
Phacotrabeculectomy in treatment of primary angle-closure glaucoma and primary open-angle glaucoma. (15295672)
2004
29
Argon laser peripheral iridoplasty versus conventional systemic medical therapy in treatment of acute primary angle-closure glaucoma : a prospective, randomized, controlled trial. (12208703)
2002
30
Morphologic features of degeneration and cell death in the neurosensory retina in dogs with primary angle-closure glaucoma. (11843127)
2002
31
Ocular biometry in the subtypes of primary angle closure glaucoma in University Malaya Medical Centre. (11732081)
2001
32
Detection of gonioscopically occludable angles and primary angle closure glaucoma by estimation of limbal chamber depth in Asians: modified grading scheme. (10655196)
2000
33
Anterior chamber depth measurement as a screening tool for primary angle-closure glaucoma in an East Asian population. (10676792)
2000
34
Retinal and subhyaloid hemorrhage as a complication of laser iridectomy for primary angle-closure glaucoma. (11030835)
2000
35
Rates of hospital admissions for primary angle closure glaucoma among Chinese, Malays, and Indians in Singapore. (10966951)
2000
36
Ultrasound biomicroscopic and conventional ultrasonographic study of ocular dimensions in primary angle-closure glaucoma. (9818611)
1998
37
Extracapsular cataract extraction with posterior chamber lens implantation in primary angle-closure glaucoma. (9292680)
1997
38
Dilated, miotic-resistant pupil and laser iridotomy in primary angle-closure glaucoma. (9216007)
1997
39
A method of image analysis for primary angle closure glaucoma. (7630615)
1995
40
Distribution and morphology of peripheral anterior synechiae in primary-angle closure glaucoma. (19920559)
1994
41
Effect of peripheral iridectomy on intraocular pressure in chronic primary angle closure glaucoma. (8181426)
1993
42
Genetic spontaneous late subluxation of the lens previously reported as a myopic kinship with primary angle closure glaucoma. (1520099)
1992
43
Issues in the epidemiology and population-based screening of primary angle-closure glaucoma. (1589856)
1992
44
Argon laser iridoplasty: a primary mode of therapy in primary angle closure glaucoma. (1841898)
1991
45
The clinical course in primary angle-closure glaucoma: a reassessment. (3730919)
1986
46
Treatment of primary angle-closure glaucoma by argon laser iridotomy: a long-term follow-up. (4010079)
1985
47
The treatment of acute attack of primary angle-closure glaucoma by pilocarpine ocusert system. (6501558)
1984
48
The endothelium in primary angle-closure glaucoma. (6742065)
1984
49
Management of chronic or intermittent primary angle-closure glaucoma: a long-term follow-up of the results of peripheral iridectomy used as an initial procedure. (760772)
1979
50
Primary angle-closure glaucoma: changing concepts of inheritance and environment. (5161774)
1971

Variations for Primary Angle-Closure Glaucoma

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Expression for genes affiliated with Primary Angle-Closure Glaucoma

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Search GEO for disease gene expression data for Primary Angle-Closure Glaucoma.

Pathways for genes affiliated with Primary Angle-Closure Glaucoma

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Pathways related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6VAV2, VAV3
2
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.2NOS3, HGF, NTF4, VAV2

Compounds for genes affiliated with Primary Angle-Closure Glaucoma

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Compounds related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

(show all 42)
idCompoundScoreTop Affiliating Genes
1cholestyramine4310.1LDLR, APOE
2lathosterol43 2411.1LDLR, APOE
3sele4310.0LDLR, APOE
4ursodeoxycholic acid43 24 1212.0HGF, LDLR, APOE
5rosuvastatin43 49 28 1213.0APOE, LDLR, NOS3
6fenofibrate43 49 1212.0APOE, LDLR, NOS3
7fluvastatin43 49 28 1212.9NOS3, LDLR, APOE
8bleomycin43 1210.9NOS3, HGF, APOE
9lactacystin439.9CTSA, HGF, APOE
10suramin43 28 1211.9HGF, LDLR, APOE
11metoprolol43 49 28 24 1213.9LDLR, NOS3
12pravastatin43 49 28 24 1213.9APOE, LDLR, NOS3
13palmitate439.8APOE, LDLR, NOS3
1422r-hydroxycholesterol43 2810.8APOE, LDLR
15streptozotocin439.7NOS3, HGF, LDLR, APOE
16nmda43 2810.7APOE, LDLR, NTF4, HGF
17folate439.7NOS3, HGF, LDLR, APOE
18prostacyclin439.7APOE, LDLR, HGF, NOS3
19atorvastatin43 49 28 24 1213.7APOE, LDLR, NOS3
20aspirin43 49 28 2412.7APOE, LDLR, HGF, NOS3
21mg 13243 5910.7NOS3, HGF, CYP1B1
22tamoxifen43 49 28 1212.7NOS3, LDLR, APOE, CYP1B1
23acetylcholine43 49 28 24 1213.7APOE, LDLR, NTF4, NOS3
24indomethacin43 28 59 1212.7APOE, LDLR, HGF, NOS3
25vitamin d439.6APOE, LDLR, HGF, NOS3
26n acetylcysteine439.6CYP1B1, APOE, MUC5AC, HGF
27dimyristoylphosphatidylcholine439.6LDLR, APOE
28actinomycin d439.6APOE, LDLR, HGF, NOS3
29cycloheximide439.6CYP1B1, APOE, MYOC, LDLR, HGF
30ascorbic acid43 2410.5APOE, MYOC, LDLR, HGF, NOS3
31genistein43 28 59 2 24 1214.5NOS3, HGF, LDLR, CYP1B1
32h2o2439.4NOS3, HGF, LDLR, APOE, CYP1B1
33adenylate439.4CYP1B1, LDLR, NTF4, HGF, CALCRL
34arginine439.3APOE, MYOC, LDLR, NTF4, HGF, NOS3
35glutamate439.3CYP1B1, APOE, LDLR, NTF4, HGF, NOS3
36alanine439.3APOE, MYOC, LDLR, NTF4, HGF
37retinoic acid43 2410.2CYP1B1, MUC5AC, LDLR, NTF4, HGF, NOS3
38estrogen439.1CYP1B1, APOE, MUC5AC, LDLR, HGF, NOS3
39testosterone43 59 24 1212.1HGF, LDLR, VAV3, MUC5AC, APOE, CYP1B1
40dexamethasone43 49 28 1211.9CYP1B1, MYOC, MUC5AC, LDLR, HGF, CALCRL
41phosphatidylinositol438.9MUC5AC, VAV3, VAV2, NTF4, HGF, NOS3
42serine438.1CYP1B1, APOE, MUC5AC, VAV2, LDLR, NTF4

GO Terms for genes affiliated with Primary Angle-Closure Glaucoma

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Cellular components related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particleGO:00343629.9LDLR, APOE

Biological processes related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein catabolic processGO:00421599.9APOE, LDLR
2nitric oxide mediated signal transductionGO:00072639.9NOS3, APOE
3negative regulation of platelet activationGO:00105449.8NOS3, APOE
4negative regulation of release of cytochrome c from mitochondriaGO:00902019.7OPA1, HGF
5angiogenesisGO:00015258.7NOS3, CALCRL, VAV2, VAV3, CYP1B1

Products for genes affiliated with Primary Angle-Closure Glaucoma

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Sources for Primary Angle-Closure Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet