MCID: PRM024
MIFTS: 46

Primary Angle-Closure Glaucoma malady

Eye diseases category

Summaries for Primary Angle-Closure Glaucoma

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Primary Angle-Closure Glaucoma, also known as primary angle-closure glaucoma, unspecified, is related to glaucoma and primary open angle glaucoma. An important gene associated with Primary Angle-Closure Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are Syndecan-1-mediated signaling events and EPHA2 forward signaling. The compounds vitamin d and hydroxyproline have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and retina, and related mouse phenotypes are integument and cardiovascular system.

Aliases & Classifications for Primary Angle-Closure Glaucoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 27ICD9CM, 60UMLS, 56SNOMED-CT, 39NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

primary angle-closure glaucoma 8 10 44
primary angle-closure glaucoma, unspecified 8
unspecified primary angle-closure glaucoma 8
primary angle-closure glaucoma, nos 8
primary angle-closure glaucoma nos 8
primary angle closure glaucoma 8


External Ids:

Disease Ontology8 DOID:1405
ICD9CM27 365.20, 365.2
NCIt39 C34640
ICD1025 H40.2

Related Diseases for Primary Angle-Closure Glaucoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Primary Angle-Closure Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma32.2CTSA, OPTN, OPA1, NTF4, CYP1B1, LOXL1
2primary open angle glaucoma31.4CYP1B1, MYOC, OPTN
3open-angle glaucoma31.4LOXL1, OPTN, CYP1B1, OPA1, MYOC
4cataract31.2MYOC, CTSA, SPARC
5hypertension30.4MMP9, MTHFR
6retinitis10.7
7neuropathy10.5
8lens subluxation10.4
9retinitis pigmentosa10.3
10ocular hypertension10.3
11rubeosis iridis10.3
12entropion10.3
13amyotrophic lateral sclerosis10.0OPTN
14myopia 610.0MYOC
15moyamoya disease10.0PCMTD1
16primary congenital glaucoma10.0CYP1B1
17periodontitis10.0MMP9
18primary open angle glaucoma juvenile onset 110.0MYOC, CYP1B1
19hypercholesterolemia10.0LDLR
20stroke, ischemic10.0MTHFR
21low tension glaucoma10.0OPA1, OPTN
22oral cancer10.0CYP1B1, MMP9
23aortic disease10.0LDLR
24proliferative diabetic retinopathy10.0MMP9, HGF
25leber hereditary optic neuropathy10.0MYOC, OPA1
26glaucoma 3, primary congenital, d10.0OPTN, CYP1B1, MYOC
27optic nerve disease10.0OPTN, MYOC, OPA1
28blindness10.0MYOC, OPTN, OPA1
29wilms tumor10.0SPARC
30multiple sclerosis10.0MMP9
31glioblastoma multiforme10.0MMP9, CALCRL, HGF
32myocardial infarction10.0LDLR, MTHFR
33ischemia10.0CALCRL, HGF, NTF4
34arthritis10.0MMP9
35antiphospholipid syndrome10.0MTHFR, LDLR
36adenoma10.0MTHFR, CYP1B1, LDLR
37idiopathic pulmonary fibrosis10.0HGF, MMP9, SPARC
38migraine10.0MTHFR, CALCRL, LDLR
39pancreatic cancer10.0HGF, CALCRL, MMP9, SPARC
40osteosarcoma10.0MMP9, CALCRL, SPARC, LDLR
41arteriosclerosis10.0LDLR, MTHFR, HGF
42coronary artery disease10.0MMP9, MTHFR, SPARC, LDLR
43malignant glioma10.0SPARC, MMP9, CYP1B1, CALCRL, HGF
44atherosclerosis10.0MTHFR, LDLR, SPARC, MMP9
45kidney cancer10.0CYP1B1, MMP9, SPARC, HGF
46pulmonary fibrosis10.0MMP9, HGF, SPARC
47melanoma10.0MMP9, HGF, CTSA, SPARC, CYP1B1, NTF4
48prostate cancer10.0CYP1B1, HGF, LDLR, SPARC, MMP9, VAV3

Graphical network of the top 20 diseases related to Primary Angle-Closure Glaucoma:



Diseases related to primary angle-closure glaucoma

Clinical Features for Primary Angle-Closure Glaucoma

About this section

Drugs & Therapeutics for Primary Angle-Closure Glaucoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Primary Angle-Closure Glaucoma

Drug clinical trials:

Search ClinicalTrials for Primary Angle-Closure Glaucoma

Search NIH Clinical Center for Primary Angle-Closure Glaucoma

Search CenterWatch for Primary Angle-Closure Glaucoma

Genetic Tests for Primary Angle-Closure Glaucoma

About this section

Anatomical Context for Primary Angle-Closure Glaucoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Primary Angle-Closure Glaucoma:

32
Eye, Testes, Retina, Endothelial

Animal Models for Primary Angle-Closure Glaucoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Primary Angle-Closure Glaucoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0LOXL1, CALCRL, CTSA, MTHFR, NTF4, MMP9
2MP:00053858.6HGF, CALCRL, CTSA, OPA1, VAV2, VAV3
3MP:00053848.5CALCRL, CTSA, OPA1, NTF4, VAV2, VAV3
4MP:00036318.3MFRP, OPA1, MTHFR, NTF4, VAV2, VAV3
5MP:00053918.3LDLR, MFRP, OPA1, MTHFR, MYOC, CYP1B1
6MP:00053767.9ST18, OPA1, CTSA, CALCRL, MTHFR, CYP1B1

Publications for Primary Angle-Closure Glaucoma

About this section
Sources:
50PubMed
See all sources

Articles related to Primary Angle-Closure Glaucoma:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length. (23920366)
2013
2
Association of SOD2 Mutation (c.47T > C) with Various Primary Angle Closure Glaucoma Clinical Indices. (24070129)
2013
3
Early histopathologic changes in the retina and optic nerve in canine primary angle-closure glaucoma. (23826772)
2013
4
Association of eNOS polymorphisms with primary angle-closure glaucoma. (23422825)
2013
5
Scanning electron microscopy of the trabecular meshwork: understanding the pathogenesis of primary angle closure glaucoma. (22569378)
2012
6
Effects of combined phacoemulsification and viscogoniosynechialysis versus trabeculectomy in patients with primary angle-closure glaucoma and coexisting cataract. (22739037)
2012
7
Corneal status in primary angle-closure glaucoma with a history of acute attack. (21048505)
2012
8
Prevalence of primary angle closure and primary angle-closure glaucoma in a southwestern rural population of Japan: the Kumejima Study. (22361313)
2012
9
Comparison of ocular response analyzer parameters in chinese subjects with primary angle-closure and primary open-angle glaucoma. (21482869)
2011
10
Accuracy of intraocular lens power calculation formulas in primary angle closure glaucoma. (22131773)
2011
11
Appositional closure identified by ultrasound biomicroscopy in population-based primary angle-closure glaucoma suspects: the Liwan eye study. (21357394)
2011
12
The association of hepatocyte growth factor (HGF) gene with primary angle closure glaucoma in the Nepalese population. (21897747)
2011
13
Postoperative complications after glaucoma surgery for primary angle-closure glaucoma vs primary open-angle glaucoma. (21482857)
2011
14
Randomised controlled trial of screening and prophylactic treatment to prevent primary angle closure glaucoma. (20530662)
2010
15
Laser peripheral iridotomy with and without iridoplasty for primary angle-closure glaucoma: 1-year results of a randomized pilot study. (20472226)
2010
16
Combined trabeculectomy and cataract extraction versus trabeculectomy alone in primary angle-closure glaucoma. (19383599)
2009
17
Plateau iris in Asian subjects with primary angle closure glaucoma. (19822841)
2009
18
Recovery of corneal hysteresis after reduction of intraocular pressure in chronic primary angle-closure glaucoma. (19327738)
2009
19
Preliminary outcomes of primary phacoemulsification plus intraocular lens implantation for primary angle-closure glaucoma. (18797145)
2008
20
Current understanding of the treatment and outcome of acute primary angle-closure glaucoma: an Asian perspective. (18392300)
2008
21
The long-term effect of Nd:YAG laser iridotomy on intraocular pressure in Taiwanese eyes with primary angle-closure glaucoma. (18567560)
2008
22
Increased SPARC expression in primary angle closure glaucoma iris. (18949063)
2008
23
Central corneal thickness and visual field progression in patients with chronic primary angle-closure glaucoma with low intraocular pressure. (17258538)
2007
24
Ethnic differences in primary angle-closure glaucoma. (16552253)
2006
25
Heidelberg Retinal Tomograph (HRT 2) parameters in primary open angle glaucoma and primary angle closure glaucoma: a comparative study in an Indian population. (17060113)
2006
26
Ultrasound biomicroscopy in the subtypes of primary angle closure glaucoma. (16148588)
2005
27
Comment on 'What is the direct cost of treatment of acute primary angle closure glaucoma? The Singapore model'. (16033375)
2005
28
Phacotrabeculectomy in treatment of primary angle-closure glaucoma and primary open-angle glaucoma. (15295672)
2004
29
Visual field loss from primary angle-closure glaucoma: a comparative study of symptomatic and asymptomatic disease. (15350315)
2004
30
Relationship between the extent of peripheral anterior synechiae and the severity of visual field defects in primary angle-closure glaucoma. (15635822)
2004
31
Uveal effusion and angle-closure glaucoma in primary pulmonary hypertension. (12719080)
2003
32
Cataract surgery in patients with acute primary angle-closure glaucoma. (14717490)
2003
33
Efficacy and safety of immediate anterior chamber paracentesis in the treatment of acute primary angle-closure glaucoma: a pilot study. (11772581)
2002
34
Synechial angle closure pattern in Chinese chronic primary angle-closure glaucoma patients. (11711843)
2001
35
Anterior chamber depth measurement as a screening tool for primary angle-closure glaucoma in an East Asian population. (10676792)
2000
36
Distribution and morphology of peripheral anterior synechiae in primary-angle closure glaucoma. (19920559)
1994
37
Effect of peripheral iridectomy on intraocular pressure in chronic primary angle closure glaucoma. (8181426)
1993
38
Primary angle closure glaucoma and retinitis pigmentosa. (8154244)
1993
39
Genetic spontaneous late subluxation of the lens previously reported as a myopic kinship with primary angle closure glaucoma. (1520099)
1992
40
Issues in the epidemiology and population-based screening of primary angle-closure glaucoma. (1589856)
1992
41
Primary angle closure glaucoma: extracapsular cataract extraction or filtering procedure? (3229905)
1988
42
Primary angle-closure glaucoma among Alaskan Eskimos. (3266136)
1988
43
Early detection of primary angle-closure glaucoma. Limbal and axial chamber depth screening in a high risk population (Greenland Eskimos). (3218480)
1988
44
The treatment of acute attack of primary angle-closure glaucoma by pilocarpine ocusert system. (6501558)
1984
45
Rubeosis iridis and primary angle-closure glaucoma. (5152653)
1971
46
Primary angle-closure glaucoma. Corticosteroid responsiveness. (5487437)
1970
47
Primary angle-closure glaucoma--problems of prevention. (5524413)
1970
48
Procrastination and acute primary angle-closure glaucoma. (5793779)
1969
49
Primary angle-closure glaucoma. Postoperative acute glaucoma after phenylephrine eyedrops. (5642908)
1968
50
Primary angle-closure glaucoma. Investigations using 10 per cent phenylephrine eyedrops. (5825145)
1965

Genetic Variations for Primary Angle-Closure Glaucoma

About this section

Expression for genes affiliated with Primary Angle-Closure Glaucoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Primary Angle-Closure Glaucoma

Search GEO for disease gene expression data for Primary Angle-Closure Glaucoma.

Pathways for genes affiliated with Primary Angle-Closure Glaucoma

About this section
Sources:
37NCBI BioSystems Database, 29KEGG
See all sources

Pathways related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MMP9, HGF
29.9VAV3, VAV2
39.7MMP9, VAV3, VAV2

Compounds for genes affiliated with Primary Angle-Closure Glaucoma

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1vitamin d4410.3HGF
2hydroxyproline44 11 2412.0HGF, MMP9, SPARC
3cyclophosphamide44 49 1112.0HGF, MTHFR, CYP1B1, MMP9
4doxycycline44 1111.0CYP1B1, MMP9, SPARC
5sele449.9LDLR, MTHFR
6carbon449.9LDLR, CYP1B1, MTHFR, HGF
7folate449.9HGF, MTHFR, MMP9, LDLR
8p002449.9MMP9, CYP1B1, MTHFR
9lactacystin449.9MMP9, CTSA, HGF
10serine449.8LDLR, MMP9, VAV2, CYP1B1
11ascorbic acid44 2410.7HGF, MTHFR, MYOC, SPARC, LDLR
12genistein44 28 59 2 11 2414.6HGF, CYP1B1, MMP9, SPARC, LDLR
13cycloheximide449.6LDLR, MMP9, CYP1B1, MYOC, HGF
14adenylate449.6HGF, CALCRL, NTF4, CYP1B1, MMP9, LDLR
15alpha tocopherol449.5MTHFR, MMP9, LDLR
16alanine449.5HGF, MTHFR, NTF4, MYOC, MMP9, LDLR
17glutamate449.5HGF, MTHFR, NTF4, CYP1B1, MMP9, LDLR
18retinoic acid44 2410.3HGF, MTHFR, NTF4, CYP1B1, MMP9, SPARC
19testosterone44 59 11 2412.2HGF, MTHFR, CYP1B1, VAV3, MMP9, SPARC
20dexamethasone44 49 28 1112.1LDLR, HGF, CALCRL, OPTN, MYOC, CYP1B1

GO Terms for genes affiliated with Primary Angle-Closure Glaucoma

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of release of cytochrome c from mitochondriaGO:09020110.1OPA1, HGF
2angiogenesisGO:0015259.4VAV3, VAV2, CYP1B1, CALCRL
3platelet activationGO:0301689.1HGF, VAV2, VAV3, SPARC

Products for genes affiliated with Primary Angle-Closure Glaucoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Primary Angle-Closure Glaucoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet