MCID: PRM024
MIFTS: 42

Primary Angle-Closure Glaucoma

Categories: Eye diseases

Aliases & Classifications for Primary Angle-Closure Glaucoma

MalaCards integrated aliases for Primary Angle-Closure Glaucoma:

Name: Primary Angle-Closure Glaucoma 12 51 14 69
Primary Angle Closure Glaucoma 12
Angle Closure Glaucoma 69

Classifications:



Summaries for Primary Angle-Closure Glaucoma

MalaCards based summary : Primary Angle-Closure Glaucoma, also known as primary angle closure glaucoma, is related to glaucoma, primary open angle and open-angle glaucoma. An important gene associated with Primary Angle-Closure Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways is Selenium Micronutrient Network. The drugs Topiramate and Pilocarpine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and lung, and related phenotypes are nervous system and no phenotypic analysis

Related Diseases for Primary Angle-Closure Glaucoma

Diseases related to Primary Angle-Closure Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 glaucoma, primary open angle 31.1 CYP1B1 MYOC OPTN
2 open-angle glaucoma 31.1 CYP1B1 MYOC OPTN
3 ocular hypertension 29.7 MYOC OPTN
4 cataract 10.7
5 retinitis 10.4
6 early-onset glaucoma 10.3 CYP1B1 MYOC
7 acrofrontofacionasal dysostosis 10.3 CYP1B1 OPTN
8 acute closed-angle glaucoma 10.3 MFRP OPTN
9 vitreous syneresis 10.3 COL11A1 OPTN
10 hydrophthalmos 10.3 CYP1B1 OPTN
11 mycetoma 10.3 CYP1B1 MMP9
12 esotropia 10.3 COL11A1 OPTN
13 neuropathy 10.2
14 low tension glaucoma 10.2 MYOC OPTN
15 amblyopia 10.1 MFRP OPTN
16 glaucoma 1, open angle, a 10.1 CYP1B1 MYOC OPTN
17 excessive tearing 10.1 CYP1B1 MYOC OPTN
18 endotheliitis 10.1
19 intraocular pressure quantitative trait locus 10.1 CYP1B1 MYOC OPTN
20 corneal edema 10.1 CYP1B1 MYOC OPTN
21 optic nerve disease 10.1 MFRP MYOC OPTN
22 primary congenital glaucoma 10.1 CYP1B1 MYOC OPTN
23 juvenile glaucoma 10.1 CYP1B1 MYOC OPTN
24 glaucoma 3, primary congenital, a 10.1 CYP1B1 MYOC OPTN
25 nervous system disease 10.0 MFRP MYOC OPTN
26 amaurosis fugax 10.0 MMP9 MTHFR
27 retinitis pigmentosa 10.0
28 aging 10.0
29 leber congenital amaurosis 4 10.0
30 anxiety 10.0
31 cornea plana 10.0
32 choroiditis 10.0
33 entropion 10.0
34 rubeosis iridis 10.0
35 refractive error 10.0
36 axenfeld-rieger syndrome 10.0 CYP1B1 OPTN
37 myopia 10.0 COL11A1 MFRP MYOC
38 microphthalmia, isolated 1 9.9 MFRP VSX2
39 coloboma of macula 9.9 MFRP OPTN VSX2
40 mastoiditis 9.8 KERA MTHFR
41 ewing sarcoma 9.8 MFRP MMP9 MYOC OPTN
42 lens subluxation 9.7 MTHFR VSX2
43 arteries, anomalies of 9.6 ABCA1 MMP9 MTHFR

Comorbidity relations with Primary Angle-Closure Glaucoma via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Primary Angle-Closure Glaucoma:



Diseases related to Primary Angle-Closure Glaucoma

Symptoms & Phenotypes for Primary Angle-Closure Glaucoma

MGI Mouse Phenotypes related to Primary Angle-Closure Glaucoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.76 ABCA1 COL11A1 MFRP MMP9 MTHFR PARL
2 no phenotypic analysis MP:0003012 9.43 MTHFR MYOC OPTN PARL TXNRD2 VSX2
3 vision/eye MP:0005391 9.23 ABCA1 CYP1B1 KERA MFRP MMP9 MTHFR

Drugs & Therapeutics for Primary Angle-Closure Glaucoma

Drugs for Primary Angle-Closure Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 4 97240-79-4 5284627
2
Pilocarpine Approved, Investigational Phase 4 92-13-7, 54-71-7 5910
3
Travoprost Approved Phase 4,Phase 3 157283-68-6 5282226
4
Latanoprost Approved, Investigational Phase 4,Phase 3 130209-82-4 5311221 5282380
5
Brinzolamide Approved Phase 4,Phase 3 138890-62-7 68844
6
Timolol Approved Phase 4,Phase 3 26839-75-8 5478 33624
7
Maleic acid Experimental Phase 4 110-16-7 444266
8 Anticonvulsants Phase 4
9 Anti-Obesity Agents Phase 4
10 Neuroprotective Agents Phase 4,Phase 2
11 Protective Agents Phase 4,Phase 2
12 Antihypertensive Agents Phase 4,Phase 3,Phase 2
13 Autonomic Agents Phase 4,Phase 2,Phase 3
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
15 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
16 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
17 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3
18 Adrenergic Agents Phase 4,Phase 3,Phase 2
19 Adrenergic Agonists Phase 4,Phase 3,Phase 2
20 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3
21 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
22 Adrenergic Antagonists Phase 4,Phase 3
23 Adrenergic beta-Antagonists Phase 4,Phase 3
24 Anti-Arrhythmia Agents Phase 4,Phase 3
25 Brimonidine Tartrate Phase 4,Phase 3 70359-46-5
26 Cholinergic Agents Phase 4
27 Carbonic Anhydrase Inhibitors Phase 4
28 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
29
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
30
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
31 Racepinephrine Approved Phase 2, Phase 3 329-65-7
32 Tetrahydrozoline Phase 3
33 Anti-Inflammatory Agents Phase 2, Phase 3
34 glucocorticoids Phase 2, Phase 3
35 Hormone Antagonists Phase 2, Phase 3
36 Hormones Phase 2, Phase 3
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
38 Alkylating Agents Phase 3
39 Anti-Bacterial Agents Phase 3
40 Antibiotics, Antitubercular Phase 3
41 Mitomycins Phase 3
42 Nucleic Acid Synthesis Inhibitors Phase 3
43 Immunosuppressive Agents Phase 2, Phase 3
44 triamcinolone acetonide Phase 2, Phase 3
45 Triamcinolone diacetate Phase 2, Phase 3
46 Triamcinolone hexacetonide Phase 2, Phase 3
47 Adrenergic beta-Agonists Phase 2, Phase 3
48 Anti-Asthmatic Agents Phase 2, Phase 3
49 Bronchodilator Agents Phase 2, Phase 3
50 Respiratory System Agents Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 51)

# Name Status NCT ID Phase Drugs
1 Relationship Between Topiramate Use and Ocular Angle Status Unknown status NCT00153699 Phase 4 Topiramate
2 Combined Phacotube vs Phacotrabeculectomy:A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
3 Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG) Completed NCT00762645 Phase 4 Travoprost 0.004% (Travatan);Pilocarpine 1%
4 Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z® Completed NCT00799682 Phase 4 Xalatan;Travatan Z
5 Azopt (Brinzolamide 1.0%) Plus Travatan (Travoprost 0.004%) in Treating Patients With Chronic Angle-Closure Glaucoma (CACG) Terminated NCT00758342 Phase 4 Travoprost 0.004% + Brinzolamide 1.0%;Travoprost 0.004% + Tears Natural
6 Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients Terminated NCT01151904 Phase 4 brimonidine 0.2%/timolol 0.5% fixed combination ophthalmic solution;latanoprost
7 Argon Laser Peripheral Iridoplasty for Primary Angle Closure Glaucoma Unknown status NCT00980473 Phase 3 Travatan/ Timolol/Azopt
8 Intraocular Pressure (IOP) Lowering Effect of Selective Laser Trabeculoplasty Versus Prostaglandin Analogues in Angle Closure Glaucoma Unknown status NCT01004900 Phase 3 Travoprost/ Timolol/ Azopt/ Brimonidine
9 A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma Completed NCT00051181 Phase 3 Travoprost (0.004%);Latanoprost (0.005%)
10 Oculusgen (Ologen) Glaucoma MMC Control in Estonia Completed NCT00524758 Phase 3 MMC in Trabeculectomy
11 Will the Use of Triesence During Glaucoma Surgery Provide Lower Eye Pressure and Improve the Results of the Surgery? Completed NCT00853905 Phase 2, Phase 3 Triesence;balanced salt solution BSS
12 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Recruiting NCT03126968 Phase 2, Phase 3 Topical epinephrine;Placebos
13 Safety and Effectiveness of the XEN45 Glaucoma Treatment System in Patients With Angle Closure Glaucoma Not yet recruiting NCT03362931 Phase 3
14 A Study to Assess the Effect of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma Unknown status NCT02152774 Phase 2 Rho-Kinase Inhibitor
15 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Unknown status NCT02416128 Phase 2 Euphrasia;Prednisolone acetate
16 Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG) Completed NCT01965106 Phase 2 QPI-1007 Injection;(including placebo)
17 Comparison of Bimatoprost and Latanoprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study Unknown status NCT00567788 Latanoprost-Bimatoprost;Bimatoporost-Latanoprost
18 The Genetic Study of Primary Angle-Closure Glaucoma Unknown status NCT00155857
19 Optical Coherence Tomography Quantitative Analysis of Changes in Anterior Chamber After Laser Peripheral Lridotomy Unknown status NCT02279472
20 Prevalence of Angle Closure in Caucasian Hyperopes Unknown status NCT00823706
21 Angle Closure (Glaucoma) in Caucasians Unknown status NCT02054403
22 Protective Effect of Phenytoin on Glaucoma Unknown status NCT00739154
23 Comparison of Phacotrabeculectomy and Trabeculectomy in the Treatment of Primary Angle-closure Glaucoma (PACG) Completed NCT01298635
24 Prevalence of Corneal Astigmatism Before Glaucoma Surgery in Chinese Patients With Primary Angle-closure Glaucoma Completed NCT03159780
25 Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma Completed NCT01266343
26 Primary Angle Closure Glaucoma and Aqueous Dynamics Completed NCT00719290
27 Laser Iridotomy Versus Phacoemulsification in Acute Angle Closure Completed NCT00350428
28 An Open Label Study Assessing the 24-hour Intraocular Pressure Pattern in PAC and PACG Patients, Before and After Laser Peripheral Iridotomy Completed NCT01906138
29 Comparison of Gonioscopy With Cirrus and Visante Completed NCT01895686
30 Dysphotopsia Following Laser Peripheral Iridotomy Completed NCT01758237
31 Water Drinking Test in Patients With Occludable Angle Completed NCT02613533
32 Prospective Evaluation of the Efficacy of Pascal Laser Iridotomy and Pascal Laser Peripheral Iridoplasty: A Pilot Study Completed NCT01020071
33 Short-term Outcomes of Iridoplasty for Persistent Angle Closure Despite Patent Iridotomies Completed NCT02199158
34 Comparison of Superior vs Nasal/Temporal Laser Peripheral Iridotomy in Primary Angle Closure Completed NCT03187821
35 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998
36 Role of Polymorphisms in the IL-1 Gene Cluster Completed NCT00346541
37 Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure Completed NCT01923454 Acetazolamide
38 Will Listening to Music Make it Easier to Take a Visual Field Test? Completed NCT01027039
39 A Drug Utilisation Post-authorisation Study of New Users of Aclidinium Bromide (Monotherapy or in Combination) Completed NCT03333018 Aclidinium bromide;Aclidinium bromide/formoterol;Other COPD medication
40 Study on Ex-PRESS Implantation Combined With Phacoemulsification in Primary Angle-closure Glaucoma Recruiting NCT03323138
41 Investigating the Genetic Basis of Pseudoexfoliation Syndrome and Angle-closure Glaucoma Recruiting NCT03423758
42 Comparing Nd:YAG Laser and Sequential Double Frequency YAG-Nd:YAG Laser Iridotomy Recruiting NCT02474238
43 Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot Study Recruiting NCT02865473 Pilocarpine
44 Treatment Outcomes of MicroPulse Trans-scleral Cyclophotocoagulation in Uncontrolled Glaucoma Recruiting NCT03187418
45 Clinical Study of LPI on Different Sites of Iris Active, not recruiting NCT02870504
46 Clinical Study of LPI With Different Laser Wavelengths Active, not recruiting NCT02901730
47 Advanced Glaucoma Progression Study Active, not recruiting NCT01742819
48 Clinical Efficacy and Safety of Minimally Invasive Glaucoma Surgery on Primary Angle Closure Glaucoma Not yet recruiting NCT02964676
49 Visual Field Defect Estimation Using Sequentially Optimized Reconstruction Strategy on Healthy and Glaucoma Subjects Not yet recruiting NCT03325751
50 Patch Graft Material Safety and Effectiveness in Covering Glaucoma Drainage Device Tube Terminated NCT01301378

Search NIH Clinical Center for Primary Angle-Closure Glaucoma

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Primary Angle-Closure Glaucoma

Anatomical Context for Primary Angle-Closure Glaucoma

MalaCards organs/tissues related to Primary Angle-Closure Glaucoma:

38
Eye, Testes, Lung, Retina, Neutrophil, Endothelial, Monocytes

Publications for Primary Angle-Closure Glaucoma

Articles related to Primary Angle-Closure Glaucoma:

(show top 50) (show all 395)
# Title Authors Year
1
Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in Patients with Early Stages of Angle-Closure Disease. ( 29310965 )
2018
2
Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography. ( 29419642 )
2018
3
Trabeculectomy With Mitomycin-C: Outcomes and Risk Factors for Failure in Primary Angle-closure Glaucoma. ( 29240597 )
2018
4
Differences between fellow eyes of acute and chronic primary angle closure (glaucoma): An ultrasound biomicroscopy quantitative study. ( 29447247 )
2018
5
Association of Plasma Complement C3 Levels With Primary Angle-Closure Glaucoma in Older Women. ( 28134964 )
2017
6
Plateau Iris Distribution Across Anterior Segment Optical Coherence Tomography Defined Subgroups of Subjects With Primary Angle Closure Glaucoma. ( 28986594 )
2017
7
Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With Primary Angle-Closure Glaucoma in Chinese. ( 28813580 )
2017
8
Comparison of self-measured diurnal intraocular pressure profiles using rebound tonometry between primary angle closure glaucoma and primary open angle glaucoma patients. ( 28333942 )
2017
9
Biometric Differences between Unilateral Chronic Primary Angle Closure Glaucoma and Fellow Non-Glaucomatous Eyes. ( 29185835 )
2017
10
Decision-making Impairments in Primary Angle-closure Glaucoma Patients. ( 28584204 )
2017
11
Long-Term Outcomes of Primary Trabeculectomy in Diabetic Patients without Retinopathy with Primary Angle-Closure Glaucoma. ( 28337343 )
2017
12
Treatment of primary angle-closure glaucoma: Does early lens extraction help? ( 28816215 )
2017
13
Cost-effectiveness of Phacoemulsification versus Combined Phacotrabeculectomy for Treating Primary Angle Closure Glaucoma. ( 28858162 )
2017
14
Visual Field Progression in Patients with Primary Angle-Closure Glaucoma Using Pointwise Linear Regression Analysis. ( 28372858 )
2017
15
Multiplex Cytokine Analysis of Aqueous Humor from the Patients with Chronic Primary Angle Closure Glaucoma. ( 28937875 )
2017
16
Success rates of 2-site phacoemulsification combined with fornix-based trabeculectomy using mitomycin C for primary angle-closure glaucoma and primary open-angle glaucoma in an Asian population. ( 28188405 )
2017
17
Evaluation of potential risk factors for development of primary angle-closure glaucoma in Bouviers des Flandres. ( 28001106 )
2017
18
A new approach for the management of primary angle-closure glaucoma after EAGLE trial. ( 28522116 )
2017
19
Re: Narayanaswamy etA al.: Argon laser peripheral iridoplasty for primary angle-closure glaucoma: a randomized controlled trial (Ophthalmology. 2016;123:514-521). ( 28335943 )
2017
20
Long-Term Evaluation of Specular Microscopic Changes Following Nd: YAG Iridotomy in Chronic Primary Angle-Closure Glaucoma Eyes. ( 28731934 )
2017
21
Association between coagulation function and patients with primary angle closure glaucoma: a 5-year retrospective case-control study. ( 29102986 )
2017
22
Common polymorphisms of the hOGG1, APE1 and XRCC1 genes correlate with the susceptibility and clinicopathological features of primary angle-closure glaucoma. ( 28396513 )
2017
23
Trabecular Meshwork Height in Primary Open-Angle Glaucoma Versus Primary Angle-Closure Glaucoma. ( 28887118 )
2017
24
Long-chain unsaturated fatty acids as possible important metabolites for primary angle-closure glaucoma based on targeted metabolomic analysis. ( 28214354 )
2017
25
Vessel Density and Structural Measurements of Optical Coherence Tomography in Primary Angle Closure and Primary Angle Closure Glaucoma. ( 28254626 )
2017
26
Resident-performed laser peripheral iridotomy in primary angle closure, primary angle closure suspects, and primary angle closure glaucoma. ( 29081648 )
2017
27
The diagnostic value of white blood cell, neutrophil, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio in patients with primary angle closure glaucoma. ( 28978173 )
2017
28
Anterior Segment Morphology in Primary Angle Closure Glaucoma using Ultrasound Biomicroscopy. ( 29151682 )
2017
29
Phacoemulsification versus laser iridotomy in primary angle closure glaucoma. A difficult decision. ( 28610807 )
2017
30
Early lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma: an economic evaluation based on data from the EAGLE trial. ( 28087548 )
2017
31
Increased aquaporin-1 levels in lens epithelial cells with primary angle-closure glaucoma. ( 28730113 )
2017
32
Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function. ( 29016860 )
2017
33
Associated factors of acute primary angle closure glaucoma in a sub-group of Chinese people: comparison between attack eyes and normal controls. ( 29097742 )
2017
34
Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma. ( 28797550 )
2017
35
Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma. ( 29082039 )
2017
36
Patient-Reported Vision-Related Quality-of-Life Differences between Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma. ( 27690232 )
2016
37
The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study. ( 27926530 )
2016
38
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. ( 27064256 )
2016
39
Verification of a formula developed to predict the postoperative intraocular pressure after cataract surgery in primary angle-closure glaucoma. ( 27686500 )
2016
40
Factors affecting refractive outcome after cataract surgery in primary angle-closure glaucoma: methodological issues of prediction model. ( 27526198 )
2016
41
Primary angle-closure glaucoma: A retrospective interventional case series in South India. ( 27013823 )
2016
42
Pattern of Visual Field Loss in Primary Angle-Closure Glaucoma Across Different Severity Levels. ( 27423311 )
2016
43
Association of Matrix Metalloproteinase-9 (MMP9) Variants with Primary Angle Closure and Primary Angle Closure Glaucoma. ( 27272641 )
2016
44
Impact of Socioeconomic Status on the Diagnosis of Primary Open-Angle Glaucoma and Primary Angle Closure Glaucoma: A Nationwide Population-Based Study in Taiwan. ( 26905307 )
2016
45
Limbus-insertion distance of superior rectus in primary angle closure glaucoma: an anterior segment OCT study. ( 27938955 )
2016
46
Primary angle closure glaucoma: What we know and what we don't know. ( 28039061 )
2016
47
[Association of PLEKHA7, COL11A1 and PCMTD1-ST18 gene polymorphisms with primary angle closure glaucoma in ethnic Han Chinese from Sichuan]. ( 27455018 )
2016
48
Re: Narayanaswamy etA al.: Argon laser peripheral iridoplasty for primary angle-closure glaucoma: a randomized controlled trial (Ophthalmology 2016;123:514-21). ( 27450829 )
2016
49
Management of Primary Angle-Closure Glaucoma. ( 26886121 )
2016
50
Argon Laser Peripheral Iridoplasty for Primary Angle-Closure Glaucoma: A Randomized Controlled Trial. ( 26707418 )
2016

Variations for Primary Angle-Closure Glaucoma

Expression for Primary Angle-Closure Glaucoma

Search GEO for disease gene expression data for Primary Angle-Closure Glaucoma.

Pathways for Primary Angle-Closure Glaucoma

Pathways related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 ABCA1 MTHFR TXNRD2

GO Terms for Primary Angle-Closure Glaucoma

Cellular components related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.92 COL11A1 KERA MMP9 MYOC

Biological processes related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen fibril organization GO:0030199 9.26 COL11A1 CYP1B1
2 endodermal cell differentiation GO:0035987 9.16 COL11A1 MMP9
3 visual perception GO:0007601 9.02 COL11A1 CYP1B1 KERA MFRP VSX2
4 regulation of reactive oxygen species metabolic process GO:2000377 8.96 CYP1B1 PARL

Sources for Primary Angle-Closure Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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