MCID: PRM024
MIFTS: 49

Primary Angle-Closure Glaucoma malady

Eye diseases category

Summaries for Primary Angle-Closure Glaucoma

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34MalaCards
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MalaCards: Primary Angle-Closure Glaucoma, also known as primary angle-closure glaucoma, unspecified, is related to glaucoma and primary open angle glaucoma. An important gene associated with Primary Angle-Closure Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are EPHA2 forward signaling and Development HGF signaling pathway. The compounds cholestyramine and lathosterol have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and retina, and related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Primary Angle-Closure Glaucoma

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 59SNOMED-CT, 41NCIt, 28ICD9CM, 63UMLS, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

primary angle-closure glaucoma 9 11 46
primary angle-closure glaucoma, unspecified 9
unspecified primary angle-closure glaucoma 9
primary angle-closure glaucoma, nos 9
primary angle-closure glaucoma nos 9
primary angle closure glaucoma 9


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Disease Ontology9 DOID:1405
NCIt41 C34640
ICD9CM28 365.2, 365.20
ICD1026 H40.2

Related Diseases for Primary Angle-Closure Glaucoma

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Primary Angle-Closure Glaucoma:



Diseases related to primary angle-closure glaucoma

Symptoms for Primary Angle-Closure Glaucoma

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Drugs & Therapeutics for Primary Angle-Closure Glaucoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Primary Angle-Closure Glaucoma

Drug clinical trials:

Search ClinicalTrials for Primary Angle-Closure Glaucoma

Search NIH Clinical Center for Primary Angle-Closure Glaucoma

Search CenterWatch for Primary Angle-Closure Glaucoma

Genetic Tests for Primary Angle-Closure Glaucoma

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Anatomical Context for Primary Angle-Closure Glaucoma

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34MalaCards
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MalaCards organs/tissues related to Primary Angle-Closure Glaucoma:

34
Eye, Testes, Retina, Endothelial

Animal Models for Primary Angle-Closure Glaucoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Primary Angle-Closure Glaucoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.0APOE, VAV3, VAV2, LDLR, CALCRL, OPA1
2MP:00053818.0APOE, MUC5AC, VAV3, VAV2, LOXL1, CALCRL
3MP:00036317.9PRSS56, VAV3, VAV2, LDLR, NTF4, OPA1
4MP:00053917.9NOS3, CYP1B1, APOE, MYOC, PRSS56, VAV3
5MP:00053977.6APOE, VAV3, VAV2, LDLR, HGF, CALCRL
6MP:00053857.6APOE, VAV3, VAV2, LDLR, HGF, CALCRL
7MP:00053847.4LDLR, VAV2, VAV3, APOE, NTF4, HGF
8MP:00053877.3APOE, MUC5AC, VAV3, VAV2, LDLR, CALCRL
9MP:00053766.5CYP1B1, APOE, MUC5AC, VAV3, VAV2, LDLR

Publications for Primary Angle-Closure Glaucoma

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53PubMed
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Articles related to Primary Angle-Closure Glaucoma:

(show top 50)    (show all 278)
idTitleAuthorsYear
1
Genetic susceptibility to primary angle closure glaucoma (PACG). (23375010)
2013
2
Efficacy of prophylactic antiglaucoma and anti-inflammatory medications in canine primary angle-closure glaucoma: a multicenter retrospective study (2004-2012). (23826812)
2013
3
Evaluation of PRSS56 in Chinese subjects with high hyperopia or primary angle-closure glaucoma. (24227917)
2013
4
Cataract surgery in eyes with filtered primary angle closure glaucoma. (23825710)
2013
5
Endoscope-assisted goniosynechialysis combined with phacoemulsification and intraocular lens implantation to manage primary angle-closure glaucoma. (23638419)
2013
6
Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length. (23920366)
2013
7
Scanning electron microscopy of the trabecular meshwork: understanding the pathogenesis of primary angle closure glaucoma. (22569378)
2012
8
A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma. (22933837)
2012
9
Susceptibility to primary angle closure glaucoma in Saudi Arabia: the possible role of mitochondrial DNA ancestry informative haplogroups. (21850192)
2011
10
The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial. (21605352)
2011
11
Surgical treatment for primary angle closure-glaucoma: a Meta analysis. (22553649)
2011
12
Ultrasound biomicroscopic assessment of angle parameters in patients with primary angle closure glaucoma undergoing phacoemulsification. (21279978)
2011
13
The evaluation of the oxidative stress parameters in patients with primary angle-closure glaucoma. (22096540)
2011
14
Comment on Effects of phacoemulsification versus combined phacotrabeculectomy on drainage angle status in primary angle closure glaucoma. (20935531)
2010
15
Effects of phacoemulsification versus combined phaco-trabeculectomy on drainage angle status in primary angle closure glaucoma (PACG). (19373107)
2010
16
The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy. (21139981)
2010
17
Getting the red out: primary angle-closure glaucoma. (19390391)
2009
18
Recovery of corneal hysteresis after reduction of intraocular pressure in chronic primary angle-closure glaucoma. (19782799)
2009
19
Study of biometric parameters in family members of primary angle closure glaucoma patients. (17304260)
2008
20
The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas. (18223248)
2008
21
Comparing glaucomatous optic neuropathy in primary open angle and primary angle closure glaucoma eyes by scanning laser polarimetry-variable corneal compensation. (18344755)
2008
22
Primary angle-closure glaucoma. (17467540)
2007
23
Comparison of glaucomatous optic nerve damage in primary angle-closure glaucoma with and without acute attack. (16209282)
2005
24
Crossover comparison of timolol and latanoprost in chronic primary angle-closure glaucoma. (14769594)
2004
25
Entropion uveae: early sphincter atrophy, signposting primary angle closure glaucoma? (15309973)
2004
26
Systemic autonomic function in subjects with primary angle-closure glaucoma: a comparative study of symptomatic and asymptomatic disease presentation. (15068428)
2004
27
Phacotrabeculectomy in treatment of primary angle-closure glaucoma and primary open-angle glaucoma. (15295672)
2004
28
Argon laser peripheral iridoplasty versus conventional systemic medical therapy in treatment of acute primary angle-closure glaucoma : a prospective, randomized, controlled trial. (12208703)
2002
29
Morphologic features of degeneration and cell death in the neurosensory retina in dogs with primary angle-closure glaucoma. (11843127)
2002
30
Ocular biometry in the subtypes of primary angle closure glaucoma in University Malaya Medical Centre. (11732081)
2001
31
Detection of gonioscopically occludable angles and primary angle closure glaucoma by estimation of limbal chamber depth in Asians: modified grading scheme. (10655196)
2000
32
Anterior chamber depth measurement as a screening tool for primary angle-closure glaucoma in an East Asian population. (10676792)
2000
33
Retinal and subhyaloid hemorrhage as a complication of laser iridectomy for primary angle-closure glaucoma. (11030835)
2000
34
Rates of hospital admissions for primary angle closure glaucoma among Chinese, Malays, and Indians in Singapore. (10966951)
2000
35
Ultrasound biomicroscopic and conventional ultrasonographic study of ocular dimensions in primary angle-closure glaucoma. (9818611)
1998
36
Extracapsular cataract extraction with posterior chamber lens implantation in primary angle-closure glaucoma. (9292680)
1997
37
Dilated, miotic-resistant pupil and laser iridotomy in primary angle-closure glaucoma. (9216007)
1997
38
A method of image analysis for primary angle closure glaucoma. (7630615)
1995
39
Distribution and morphology of peripheral anterior synechiae in primary-angle closure glaucoma. (19920559)
1994
40
Effect of peripheral iridectomy on intraocular pressure in chronic primary angle closure glaucoma. (8181426)
1993
41
Genetic spontaneous late subluxation of the lens previously reported as a myopic kinship with primary angle closure glaucoma. (1520099)
1992
42
Issues in the epidemiology and population-based screening of primary angle-closure glaucoma. (1589856)
1992
43
Argon laser iridoplasty: a primary mode of therapy in primary angle closure glaucoma. (1841898)
1991
44
The clinical course in primary angle-closure glaucoma: a reassessment. (3730919)
1986
45
Treatment of primary angle-closure glaucoma by argon laser iridotomy: a long-term follow-up. (4010079)
1985
46
The treatment of acute attack of primary angle-closure glaucoma by pilocarpine ocusert system. (6501558)
1984
47
Management of chronic or intermittent primary angle-closure glaucoma: a long-term follow-up of the results of peripheral iridectomy used as an initial procedure. (760772)
1979
48
Primary angle-closure glaucoma: changing concepts of inheritance and environment. (5161774)
1971
49
Primary angle-closure glaucoma. Postoperative acute glaucoma after phenylephrine eyedrops. (5642908)
1968
50
PRIMARY ANGLE-CLOSURE GLAUCOMA, INVESTIGATIONS AFTER SURGERY FOR PUPIL BLOCK. (14167218)
1964

Variations for Primary Angle-Closure Glaucoma

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Expression for genes affiliated with Primary Angle-Closure Glaucoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Angle-Closure Glaucoma

Search GEO for disease gene expression data for Primary Angle-Closure Glaucoma.

Pathways for genes affiliated with Primary Angle-Closure Glaucoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG
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Pathways related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6VAV2, VAV3
2
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.2NOS3, HGF, NTF4, VAV2

Compounds for genes affiliated with Primary Angle-Closure Glaucoma

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience, 3BitterDB
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Compounds related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1cholestyramine4610.1LDLR, APOE
2lathosterol46 2511.1LDLR, APOE
3sele4610.0LDLR, APOE
4ursodeoxycholic acid46 25 1212.0HGF, LDLR, APOE
5rosuvastatin46 52 30 1213.0APOE, LDLR, NOS3
6fenofibrate46 52 1212.0APOE, LDLR, NOS3
7fluvastatin46 52 30 1212.9NOS3, LDLR, APOE
8bleomycin46 1210.9NOS3, HGF, APOE
9lactacystin469.9CTSA, HGF, APOE
10suramin46 30 1211.9HGF, LDLR, APOE
11metoprolol46 52 30 25 1213.9LDLR, NOS3
12pravastatin46 52 30 25 1213.9APOE, LDLR, NOS3
13palmitate469.8APOE, LDLR, NOS3
1422r-hydroxycholesterol46 3010.8APOE, LDLR
15streptozotocin469.7NOS3, HGF, LDLR, APOE
16nmda46 3010.7APOE, LDLR, NTF4, HGF
17folate469.7NOS3, HGF, LDLR, APOE
18prostacyclin469.7APOE, LDLR, HGF, NOS3
19atorvastatin46 52 30 25 1213.7APOE, LDLR, NOS3
20aspirin46 52 30 2512.7APOE, LDLR, HGF, NOS3
21mg 13246 6210.7NOS3, HGF, CYP1B1
22tamoxifen46 52 30 1212.7NOS3, LDLR, APOE, CYP1B1
23acetylcholine46 52 30 25 1213.7APOE, LDLR, NTF4, NOS3
24indomethacin46 30 62 1212.7APOE, LDLR, HGF, NOS3
25vitamin d469.6APOE, LDLR, HGF, NOS3
26n acetylcysteine469.6CYP1B1, APOE, MUC5AC, HGF
27dimyristoylphosphatidylcholine469.6LDLR, APOE
28actinomycin d469.6APOE, LDLR, HGF, NOS3
29cycloheximide469.6CYP1B1, APOE, MYOC, LDLR, HGF
30ascorbic acid46 2510.5APOE, MYOC, LDLR, HGF, NOS3
31genistein46 30 62 3 25 1214.5NOS3, HGF, LDLR, CYP1B1
32h2o2469.4NOS3, HGF, LDLR, APOE, CYP1B1
33adenylate469.4CYP1B1, LDLR, NTF4, HGF, CALCRL
34arginine469.3APOE, MYOC, LDLR, NTF4, HGF, NOS3
35glutamate469.3CYP1B1, APOE, LDLR, NTF4, HGF, NOS3
36alanine469.3APOE, MYOC, LDLR, NTF4, HGF
37retinoic acid46 2510.2CYP1B1, MUC5AC, LDLR, NTF4, HGF, NOS3
38estrogen469.1CYP1B1, APOE, MUC5AC, LDLR, HGF, NOS3
39testosterone46 62 25 1212.1HGF, LDLR, VAV3, MUC5AC, APOE, CYP1B1
40dexamethasone46 52 30 1211.9CYP1B1, MYOC, MUC5AC, LDLR, HGF, CALCRL
41phosphatidylinositol468.9MUC5AC, VAV3, VAV2, NTF4, HGF, NOS3
42serine468.1CYP1B1, APOE, MUC5AC, VAV2, LDLR, NTF4

GO Terms for genes affiliated with Primary Angle-Closure Glaucoma

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17Gene Ontology
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Cellular components related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particleGO:0343629.9LDLR, APOE

Biological processes related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein catabolic processGO:0421599.9APOE, LDLR
2nitric oxide mediated signal transductionGO:0072639.9NOS3, APOE
3negative regulation of platelet activationGO:0105449.8NOS3, APOE
4negative regulation of release of cytochrome c from mitochondriaGO:0902019.7OPA1, HGF
5angiogenesisGO:0015258.7NOS3, CALCRL, VAV2, VAV3, CYP1B1

Products for genes affiliated with Primary Angle-Closure Glaucoma

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Sources for Primary Angle-Closure Glaucoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet