MCID: PRM024
MIFTS: 54

Primary Angle-Closure Glaucoma malady

Eye diseases category
Download this MalaCard

Summaries for Primary Angle-Closure Glaucoma

About this section


Fully expand this MalaCard
MalaCards based summary: Primary Angle-Closure Glaucoma, also known as primary angle-closure glaucoma, unspecified, is related to primary open angle glaucoma and open-angle glaucoma. An important gene associated with Primary Angle-Closure Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are EPHA2 forward signaling and Development HGF signaling pathway. The drugs echothiophate iodide and methazolamide and the compounds cholestyramine and lathosterol have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and retina, and related mouse phenotypes are muscle and digestive/alimentary.

Aliases & Classifications for Primary Angle-Closure Glaucoma

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 39NCIt, 25ICD10
See all sources

Primary Angle-Closure Glaucoma, Aliases & Descriptions:

Name: Primary Angle-Closure Glaucoma 8 10 44
Primary Angle-Closure Glaucoma, Unspecified 8 62
Unspecified Primary Angle-Closure Glaucoma 8
Primary Angle-Closure Glaucoma, Nos 8
 
Primary Angle-Closure Glaucoma Nos 8
Angle-Closure Glaucoma, Primary 62
Primary Angle Closure Glaucoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:1405
ICD9CM27 365.2, 365.20
NCIt39 C34640
ICD1025 H40.2

Related Diseases for Primary Angle-Closure Glaucoma

About this section

Graphical network of the top 20 diseases related to Primary Angle-Closure Glaucoma:



Diseases related to primary angle-closure glaucoma

Symptoms for Primary Angle-Closure Glaucoma

About this section

Drugs & Therapeutics for Primary Angle-Closure Glaucoma

About this section

Drug clinical trials:

Search ClinicalTrials for Primary Angle-Closure Glaucoma

Search NIH Clinical Center for Primary Angle-Closure Glaucoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Primary Angle-Closure Glaucoma

About this section

Anatomical Context for Primary Angle-Closure Glaucoma

About this section

MalaCards organs/tissues related to Primary Angle-Closure Glaucoma:

32
Eye, Testes, Retina, Endothelial

Animal Models for Primary Angle-Closure Glaucoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Primary Angle-Closure Glaucoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.0APOE, VAV3, VAV2, LDLR, CALCRL, OPA1
2MP:00053818.0APOE, MUC5AC, VAV3, VAV2, LOXL1, CALCRL
3MP:00036317.9PRSS56, VAV3, VAV2, LDLR, NTF4, OPA1
4MP:00053917.9NOS3, CYP1B1, APOE, MYOC, PRSS56, VAV3
5MP:00053977.6APOE, VAV3, VAV2, LDLR, HGF, CALCRL
6MP:00053857.6APOE, VAV3, VAV2, LDLR, HGF, CALCRL
7MP:00053847.4LDLR, VAV2, VAV3, APOE, NTF4, HGF
8MP:00053877.3APOE, MUC5AC, VAV3, VAV2, LDLR, CALCRL
9MP:00053766.5CYP1B1, APOE, MUC5AC, VAV3, VAV2, LDLR

Publications for Primary Angle-Closure Glaucoma

About this section

Articles related to Primary Angle-Closure Glaucoma:

(show top 50)    (show all 297)
idTitleAuthorsYear
1
Genetic susceptibility to primary angle closure glaucoma (PACG). (23375010)
2013
2
Efficacy of prophylactic antiglaucoma and anti-inflammatory medications in canine primary angle-closure glaucoma: a multicenter retrospective study (2004-2012). (23826812)
2013
3
Evaluation of PRSS56 in Chinese subjects with high hyperopia or primary angle-closure glaucoma. (24227917)
2013
4
Endoscope-assisted goniosynechialysis combined with phacoemulsification and intraocular lens implantation to manage primary angle-closure glaucoma. (23638419)
2013
5
Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length. (23920366)
2013
6
Scanning electron microscopy of the trabecular meshwork: understanding the pathogenesis of primary angle closure glaucoma. (22569378)
2012
7
A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma. (22933837)
2012
8
Susceptibility to primary angle closure glaucoma in Saudi Arabia: the possible role of mitochondrial DNA ancestry informative haplogroups. (21850192)
2011
9
The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial. (21605352)
2011
10
Surgical treatment for primary angle closure-glaucoma: a Meta analysis. (22553649)
2011
11
Ultrasound biomicroscopic assessment of angle parameters in patients with primary angle closure glaucoma undergoing phacoemulsification. (21279978)
2011
12
The evaluation of the oxidative stress parameters in patients with primary angle-closure glaucoma. (22096540)
2011
13
Outcomes of primary angle closure glaucoma management. (22204235)
2011
14
Comment on Effects of phacoemulsification versus combined phacotrabeculectomy on drainage angle status in primary angle closure glaucoma. (20935531)
2010
15
Effects of phacoemulsification versus combined phaco-trabeculectomy on drainage angle status in primary angle closure glaucoma (PACG). (19373107)
2010
16
The tear fluid mucin 5AC change of primary angle-closure glaucoma patients after short-term medications and phacotrabeculectomy. (21139981)
2010
17
Getting the red out: primary angle-closure glaucoma. (19390391)
2009
18
Recovery of corneal hysteresis after reduction of intraocular pressure in chronic primary angle-closure glaucoma. (19782799)
2009
19
Study of biometric parameters in family members of primary angle closure glaucoma patients. (17304260)
2008
20
The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas. (18223248)
2008
21
Comparing glaucomatous optic neuropathy in primary open angle and primary angle closure glaucoma eyes by scanning laser polarimetry-variable corneal compensation. (18344755)
2008
22
Primary angle-closure glaucoma. (17467540)
2007
23
Comparison of glaucomatous optic nerve damage in primary angle-closure glaucoma with and without acute attack. (16209282)
2005
24
Crossover comparison of timolol and latanoprost in chronic primary angle-closure glaucoma. (14769594)
2004
25
Entropion uveae: early sphincter atrophy, signposting primary angle closure glaucoma? (15309973)
2004
26
Systemic autonomic function in subjects with primary angle-closure glaucoma: a comparative study of symptomatic and asymptomatic disease presentation. (15068428)
2004
27
Phacotrabeculectomy in treatment of primary angle-closure glaucoma and primary open-angle glaucoma. (15295672)
2004
28
Argon laser peripheral iridoplasty versus conventional systemic medical therapy in treatment of acute primary angle-closure glaucoma : a prospective, randomized, controlled trial. (12208703)
2002
29
Morphologic features of degeneration and cell death in the neurosensory retina in dogs with primary angle-closure glaucoma. (11843127)
2002
30
Ocular biometry in the subtypes of primary angle closure glaucoma in University Malaya Medical Centre. (11732081)
2001
31
Detection of gonioscopically occludable angles and primary angle closure glaucoma by estimation of limbal chamber depth in Asians: modified grading scheme. (10655196)
2000
32
Anterior chamber depth measurement as a screening tool for primary angle-closure glaucoma in an East Asian population. (10676792)
2000
33
Retinal and subhyaloid hemorrhage as a complication of laser iridectomy for primary angle-closure glaucoma. (11030835)
2000
34
Rates of hospital admissions for primary angle closure glaucoma among Chinese, Malays, and Indians in Singapore. (10966951)
2000
35
Ultrasound biomicroscopic and conventional ultrasonographic study of ocular dimensions in primary angle-closure glaucoma. (9818611)
1998
36
Extracapsular cataract extraction with posterior chamber lens implantation in primary angle-closure glaucoma. (9292680)
1997
37
Dilated, miotic-resistant pupil and laser iridotomy in primary angle-closure glaucoma. (9216007)
1997
38
A method of image analysis for primary angle closure glaucoma. (7630615)
1995
39
Distribution and morphology of peripheral anterior synechiae in primary-angle closure glaucoma. (19920559)
1994
40
Effect of peripheral iridectomy on intraocular pressure in chronic primary angle closure glaucoma. (8181426)
1993
41
Genetic spontaneous late subluxation of the lens previously reported as a myopic kinship with primary angle closure glaucoma. (1520099)
1992
42
Issues in the epidemiology and population-based screening of primary angle-closure glaucoma. (1589856)
1992
43
Argon laser iridoplasty: a primary mode of therapy in primary angle closure glaucoma. (1841898)
1991
44
The clinical course in primary angle-closure glaucoma: a reassessment. (3730919)
1986
45
Treatment of primary angle-closure glaucoma by argon laser iridotomy: a long-term follow-up. (4010079)
1985
46
The treatment of acute attack of primary angle-closure glaucoma by pilocarpine ocusert system. (6501558)
1984
47
Management of chronic or intermittent primary angle-closure glaucoma: a long-term follow-up of the results of peripheral iridectomy used as an initial procedure. (760772)
1979
48
Primary angle-closure glaucoma: changing concepts of inheritance and environment. (5161774)
1971
49
Primary angle-closure glaucoma. Postoperative acute glaucoma after phenylephrine eyedrops. (5642908)
1968
50
PRIMARY ANGLE-CLOSURE GLAUCOMA, INVESTIGATIONS AFTER SURGERY FOR PUPIL BLOCK. (14167218)
1964

Variations for Primary Angle-Closure Glaucoma

About this section

Expression for genes affiliated with Primary Angle-Closure Glaucoma

About this section
Expression patterns in normal tissues for genes affiliated with Primary Angle-Closure Glaucoma

Search GEO for disease gene expression data for Primary Angle-Closure Glaucoma.

Pathways for genes affiliated with Primary Angle-Closure Glaucoma

About this section

Pathways related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6VAV2, VAV3
2
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.2NOS3, HGF, NTF4, VAV2

Compounds for genes affiliated with Primary Angle-Closure Glaucoma

About this section

Compounds related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1cholestyramine4410.1LDLR, APOE
2lathosterol44 2411.1LDLR, APOE
3sele4410.0LDLR, APOE
4ursodeoxycholic acid44 24 1112.0HGF, LDLR, APOE
5rosuvastatin44 50 28 1113.0APOE, LDLR, NOS3
6fenofibrate44 50 1112.0APOE, LDLR, NOS3
7fluvastatin44 50 28 1112.9NOS3, LDLR, APOE
8bleomycin44 1110.9NOS3, HGF, APOE
9lactacystin449.9CTSA, HGF, APOE
10suramin44 28 1111.9HGF, LDLR, APOE
11metoprolol44 50 28 24 1113.9LDLR, NOS3
12pravastatin44 50 28 24 1113.9APOE, LDLR, NOS3
13palmitate449.8APOE, LDLR, NOS3
1422r-hydroxycholesterol44 2810.8APOE, LDLR
15streptozotocin449.7NOS3, HGF, LDLR, APOE
16nmda44 2810.7APOE, LDLR, NTF4, HGF
17folate449.7NOS3, HGF, LDLR, APOE
18prostacyclin449.7APOE, LDLR, HGF, NOS3
19atorvastatin44 50 28 24 1113.7APOE, LDLR, NOS3
20aspirin44 50 28 2412.7APOE, LDLR, HGF, NOS3
21mg 13244 6110.7NOS3, HGF, CYP1B1
22tamoxifen44 50 28 1112.7NOS3, LDLR, APOE, CYP1B1
23acetylcholine44 50 28 24 1113.7APOE, LDLR, NTF4, NOS3
24indomethacin44 28 61 1112.7APOE, LDLR, HGF, NOS3
25vitamin d449.6APOE, LDLR, HGF, NOS3
26n acetylcysteine449.6CYP1B1, APOE, MUC5AC, HGF
27dimyristoylphosphatidylcholine449.6LDLR, APOE
28actinomycin d449.6APOE, LDLR, HGF, NOS3
29cycloheximide449.6CYP1B1, APOE, MYOC, LDLR, HGF
30ascorbic acid44 2410.5APOE, MYOC, LDLR, HGF, NOS3
31genistein44 28 61 2 24 1114.5NOS3, HGF, LDLR, CYP1B1
32h2o2449.4NOS3, HGF, LDLR, APOE, CYP1B1
33adenylate449.4CYP1B1, LDLR, NTF4, HGF, CALCRL
34arginine449.3APOE, MYOC, LDLR, NTF4, HGF, NOS3
35glutamate449.3CYP1B1, APOE, LDLR, NTF4, HGF, NOS3
36alanine449.3APOE, MYOC, LDLR, NTF4, HGF
37retinoic acid44 2410.2CYP1B1, MUC5AC, LDLR, NTF4, HGF, NOS3
38estrogen449.1CYP1B1, APOE, MUC5AC, LDLR, HGF, NOS3
39testosterone44 61 24 1112.1HGF, LDLR, VAV3, MUC5AC, APOE, CYP1B1
40dexamethasone44 50 28 1111.9CYP1B1, MYOC, MUC5AC, LDLR, HGF, CALCRL
41phosphatidylinositol448.9MUC5AC, VAV3, VAV2, NTF4, HGF, NOS3
42serine448.1CYP1B1, APOE, MUC5AC, VAV2, LDLR, NTF4

GO Terms for genes affiliated with Primary Angle-Closure Glaucoma

About this section

Cellular components related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particleGO:0343629.9LDLR, APOE

Biological processes related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein catabolic processGO:0421599.9APOE, LDLR
2nitric oxide mediated signal transductionGO:0072639.9NOS3, APOE
3negative regulation of platelet activationGO:0105449.8NOS3, APOE
4negative regulation of release of cytochrome c from mitochondriaGO:0902019.7OPA1, HGF
5angiogenesisGO:0015258.7NOS3, CALCRL, VAV2, VAV3, CYP1B1

Products for genes affiliated with Primary Angle-Closure Glaucoma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Primary Angle-Closure Glaucoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet