MCID: PRM024
MIFTS: 46

Primary Angle-Closure Glaucoma malady

Eye diseases category

Summaries for Primary Angle-Closure Glaucoma

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32MalaCards
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MalaCards: Primary Angle-Closure Glaucoma, also known as primary angle-closure glaucoma, unspecified, is related to glaucoma and primary open angle glaucoma. An important gene associated with Primary Angle-Closure Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are Syndecan-1-mediated signaling events and EPHA2 forward signaling. The compounds vitamin d and hydroxyproline have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and retina, and related mouse phenotypes are integument and cardiovascular system.

Aliases & Classifications for Primary Angle-Closure Glaucoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 27ICD9CM, 60UMLS, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

primary angle-closure glaucoma 8 10 44
primary angle-closure glaucoma, unspecified 8
unspecified primary angle-closure glaucoma 8
primary angle-closure glaucoma, nos 8
primary angle-closure glaucoma nos 8
primary angle closure glaucoma 8


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Disease Ontology8 DOID:1405
ICD9CM27 365.20, 365.2
NCIt39 C34640
ICD1025 H40.2

Related Diseases for Primary Angle-Closure Glaucoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Primary Angle-Closure Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma32.2CTSA, OPTN, OPA1, NTF4, CYP1B1, LOXL1
2primary open angle glaucoma31.4CYP1B1, MYOC, OPTN
3open-angle glaucoma31.4LOXL1, OPTN, CYP1B1, OPA1, MYOC
4cataract31.2MYOC, CTSA, SPARC
5hypertension30.4MMP9, MTHFR
6retinitis10.7
7neuropathy10.5
8lens subluxation10.4
9retinitis pigmentosa10.3
10ocular hypertension10.3
11rubeosis iridis10.3
12entropion10.3
13amyotrophic lateral sclerosis10.0OPTN
14myopia 610.0MYOC
15moyamoya disease10.0PCMTD1
16primary congenital glaucoma10.0CYP1B1
17periodontitis10.0MMP9
18primary open angle glaucoma juvenile onset 110.0MYOC, CYP1B1
19hypercholesterolemia10.0LDLR
20stroke, ischemic10.0MTHFR
21low tension glaucoma10.0OPA1, OPTN
22oral cancer10.0CYP1B1, MMP9
23aortic disease10.0LDLR
24proliferative diabetic retinopathy10.0MMP9, HGF
25leber hereditary optic neuropathy10.0MYOC, OPA1
26glaucoma 3, primary congenital, d10.0OPTN, CYP1B1, MYOC
27optic nerve disease10.0OPTN, MYOC, OPA1
28blindness10.0MYOC, OPTN, OPA1
29wilms tumor10.0SPARC
30multiple sclerosis10.0MMP9
31glioblastoma multiforme10.0MMP9, CALCRL, HGF
32myocardial infarction10.0LDLR, MTHFR
33ischemia10.0CALCRL, HGF, NTF4
34arthritis10.0MMP9
35antiphospholipid syndrome10.0MTHFR, LDLR
36adenoma10.0MTHFR, CYP1B1, LDLR
37idiopathic pulmonary fibrosis10.0HGF, MMP9, SPARC
38migraine10.0MTHFR, CALCRL, LDLR
39pancreatic cancer10.0HGF, CALCRL, MMP9, SPARC
40osteosarcoma10.0MMP9, CALCRL, SPARC, LDLR
41arteriosclerosis10.0LDLR, MTHFR, HGF
42coronary artery disease10.0MMP9, MTHFR, SPARC, LDLR
43malignant glioma10.0SPARC, MMP9, CYP1B1, CALCRL, HGF
44atherosclerosis10.0MTHFR, LDLR, SPARC, MMP9
45kidney cancer10.0CYP1B1, MMP9, SPARC, HGF
46pulmonary fibrosis10.0MMP9, HGF, SPARC
47melanoma10.0MMP9, HGF, CTSA, SPARC, CYP1B1, NTF4
48prostate cancer10.0CYP1B1, HGF, LDLR, SPARC, MMP9, VAV3

Graphical network of the top 20 diseases related to Primary Angle-Closure Glaucoma:



Diseases related to primary angle-closure glaucoma

Clinical Features for Primary Angle-Closure Glaucoma

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Drugs & Therapeutics for Primary Angle-Closure Glaucoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Primary Angle-Closure Glaucoma

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Anatomical Context for Primary Angle-Closure Glaucoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Primary Angle-Closure Glaucoma:

32
Eye, Testes, Retina, Endothelial

Animal Models for Primary Angle-Closure Glaucoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Primary Angle-Closure Glaucoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0MMP9, NTF4, MTHFR, CTSA, LOXL1, CALCRL
2MP:00053858.6CTSA, HGF, CALCRL, OPA1, VAV2, VAV3
3MP:00053848.5HGF, LDLR, MMP9, CALCRL, VAV3, CTSA
4MP:00036318.3NTF4, MTHFR, OPA1, VAV2, MFRP, VAV3
5MP:00053918.3OPA1, MFRP, LDLR, SPARC, VSX2, VAV3
6MP:00053767.9SPARC, MMP9, VAV3, VAV2, CYP1B1, MTHFR

Publications for Primary Angle-Closure Glaucoma

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50PubMed
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Articles related to Primary Angle-Closure Glaucoma:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
Changes in the lamina and prelamina after intraocular pressure reduction in patients with primary open-angle glaucoma and acute primary angle-closure. (24204049)
2014
2
Polymorphisms in matrix metalloproteinases MMP1 and MMP9 are associated with primary open-angle and angle closure glaucoma in a Pakistani population. (23441116)
2013
3
Variations in iris volume with physiologic mydriasis in subtypes of primary angle closure glaucoma. (23299474)
2013
4
Interocular Asymmetry of the Visual Field Defects in Newly Diagnosed Normal-tension Glaucoma, Primary Open-angle Glaucoma, and Chronic Angle-closure Glaucoma. (23632403)
2013
5
Comparison of combined phacotrabeculectomy with trabeculectomy only in the treatment of primary angle-closure glaucoma. (22613648)
2012
6
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. (22922875)
2012
7
The effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle-closure glaucoma (EAGLE): study protocol for a randomized controlled trial. (21605352)
2011
8
Increased iris thickness and association with primary angle closure glaucoma. (20530187)
2011
9
Retinal nerve fiber layer defect patterns in primary angle-closure and open-angle glaucoma: a comparison using optical coherence tomography. (21331689)
2011
10
Central corneal thickness in Chinese subjects with primary angle closure glaucoma. (21654516)
2011
11
Determinants of long-term intraocular pressure after phacoemulsification in primary angle-closure glaucoma. (21673599)
2011
12
Comment on Effects of phacoemulsification versus combined phacotrabeculectomy on drainage angle status in primary angle closure glaucoma. (20935531)
2010
13
Functional and structural changes in a canine model of hereditary primary angle-closure glaucoma. (19661222)
2010
14
Prognostic factors for the success of laser iridotomy for acute primary angle closure glaucoma. (20046690)
2009
15
A randomised crossover study comparing bimatoprost and latanoprost in subjects with primary angle closure glaucoma. (19336424)
2009
16
Study of biometric parameters in family members of primary angle closure glaucoma patients. (17304260)
2008
17
Two variants in MYOC and CYP1B1 genes in a Chinese family with primary angle-closure glaucoma]. (18841557)
2008
18
Scanning laser polarimetry with variable corneal compensation in primary angle-closure glaucoma. (18201763)
2008
19
Characteristics of disc hemorrhage in primary angle-closure glaucoma. (18187197)
2008
20
Genetic heritability of a shallow anterior chamber in Chinese families with primary angle closure glaucoma. (19005988)
2008
21
A study on the association of apolipoprotein E genotypes with primary open-angle glaucoma and primary angle-closure glaucoma in northeast of China]. (17706090)
2007
22
Measurement of anterior lens growth after acute primary angle-closure glaucoma. (17392864)
2007
23
Nuclear and mitochondrial analysis of patients with primary angle-closure glaucoma. (18055808)
2007
24
The clinical outcomes of cataract extraction by phacoemulsification in eyes with primary angle-closure glaucoma (PACG) and co-existing cataract: a prospective case series. (16865015)
2006
25
Uveal effusion in primary angle-closure glaucoma. (15745767)
2005
26
Molecular analysis of the myocilin gene in Chinese subjects with chronic primary-angle closure glaucoma. (15790895)
2005
27
Entropion uveae: early sphincter atrophy, signposting primary angle closure glaucoma? (15309973)
2004
28
Rate of visual field progression in primary open-angle glaucoma and primary angle-closure glaucoma. (15635823)
2004
29
Use of limbal and central anterior chamber depth measurements in detecting eyes with gonioscopically occludable angles and primary angle closure glaucoma in Ibadan. (15259929)
2003
30
Argon laser peripheral iridoplasty versus conventional systemic medical therapy in treatment of acute primary angle-closure glaucoma : a prospective, randomized, controlled trial. (12208703)
2002
31
Morphologic features of degeneration and cell death in the neurosensory retina in dogs with primary angle-closure glaucoma. (11843127)
2002
32
Review of recent advancements in the understanding of primary angle-closure glaucoma. (11880721)
2002
33
Immediate diode laser peripheral iridoplasty as treatment of acute attack of primary angle closure glaucoma: a preliminary study. (11316102)
2001
34
Retinal and subhyaloid hemorrhage as a complication of laser iridectomy for primary angle-closure glaucoma. (11030835)
2000
35
Peripapillary atrophy in primary angle-closure glaucoma: a comparative study with primary open-angle glaucoma. (10030551)
1999
36
Controversies in acute primary angle closure glaucoma in Chinese people. (10571400)
1999
37
Limited argon laser peripheral iridoplasty as immediate treatment for an acute attack of primary angle closure glaucoma: a preliminary study. (10396379)
1999
38
Biometry and primary angle-closure glaucoma among Chinese, white, and black populations. (9307646)
1997
39
The prevalence of primary angle closure glaucoma and open angle glaucoma in Mamre, western Cape, South Africa. (8363470)
1993
40
Argon laser iridoplasty: a primary mode of therapy in primary angle closure glaucoma. (1841898)
1991
41
Treatment of primary angle-closure glaucoma by argon laser iridotomy: a long-term follow-up. (4010079)
1985
42
Primary angle closure glaucoma in a myopic kinship. (3977710)
1985
43
Primary angle closure glaucoma: geographic and racial variations. (4519236)
1973
44
Primary angle-closure glaucoma. A review 5 years after bilateral surgery. (4725853)
1973
45
Primary angle-closure glaucoma (a.c.g.) in Greenland. (5108817)
1971
46
Primary angle-closure glaucoma: problems of prevention. (5285278)
1970
47
The natural history and principles of treatment of primary angle-closure glaucoma. (5931260)
1966
48
PRIMARY ANGLE-CLOSURE GLAUCOMA WITH CAPSULAR EXFOLIATION OF THE LENS. (14217215)
1964
49
PRIMARY ANGLE-CLOSURE GLAUCOMA. FAMILY HISTORIES AND ANTERIOR CHAMBER DEPTHS. (14190430)
1964
50
PRIMARY ANGLE-CLOSURE GLAUCOMA: SURGERY. (14237247)
1963

Genetic Variations for Primary Angle-Closure Glaucoma

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Expression for genes affiliated with Primary Angle-Closure Glaucoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Angle-Closure Glaucoma

Search GEO for disease gene expression data for Primary Angle-Closure Glaucoma.

Pathways for genes affiliated with Primary Angle-Closure Glaucoma

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Sources:
37NCBI BioSystems Database, 29KEGG
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Pathways related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MMP9, HGF
29.9VAV3, VAV2
39.7MMP9, VAV3, VAV2

Compounds for genes affiliated with Primary Angle-Closure Glaucoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1vitamin d4410.3HGF
2hydroxyproline44 11 2412.0HGF, MMP9, SPARC
3cyclophosphamide44 49 1112.0HGF, MTHFR, CYP1B1, MMP9
4doxycycline44 1111.0CYP1B1, MMP9, SPARC
5sele449.9LDLR, MTHFR
6carbon449.9LDLR, CYP1B1, MTHFR, HGF
7folate449.9HGF, MTHFR, MMP9, LDLR
8p002449.9MMP9, CYP1B1, MTHFR
9lactacystin449.9MMP9, CTSA, HGF
10serine449.8LDLR, MMP9, VAV2, CYP1B1
11ascorbic acid44 2410.7HGF, MTHFR, MYOC, SPARC, LDLR
12genistein44 28 59 2 11 2414.6HGF, CYP1B1, MMP9, SPARC, LDLR
13cycloheximide449.6LDLR, MMP9, CYP1B1, MYOC, HGF
14adenylate449.6HGF, CALCRL, NTF4, CYP1B1, MMP9, LDLR
15alpha tocopherol449.5MTHFR, MMP9, LDLR
16alanine449.5HGF, MTHFR, NTF4, MYOC, MMP9, LDLR
17glutamate449.5HGF, MTHFR, NTF4, CYP1B1, MMP9, LDLR
18retinoic acid44 2410.3HGF, MTHFR, NTF4, CYP1B1, MMP9, SPARC
19testosterone44 59 11 2412.2HGF, MTHFR, CYP1B1, VAV3, MMP9, SPARC
20dexamethasone44 49 28 1112.1LDLR, HGF, CALCRL, OPTN, MYOC, CYP1B1

GO Terms for genes affiliated with Primary Angle-Closure Glaucoma

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16Gene Ontology
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Biological processes related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of release of cytochrome c from mitochondriaGO:09020110.1OPA1, HGF
2angiogenesisGO:0015259.4VAV3, VAV2, CYP1B1, CALCRL
3platelet activationGO:0301689.1HGF, VAV2, VAV3, SPARC

Products for genes affiliated with Primary Angle-Closure Glaucoma

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  • Antibodies
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Sources for Primary Angle-Closure Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet