MCID: PRM024
MIFTS: 39

Primary Angle-Closure Glaucoma malady

Categories: Eye diseases

Aliases & Classifications for Primary Angle-Closure Glaucoma

Aliases & Descriptions for Primary Angle-Closure Glaucoma:

Name: Primary Angle-Closure Glaucoma 12 52 14 69
Primary Angle Closure Glaucoma 12
Angle Closure Glaucoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1405
ICD10 33 H40.2 H40.20
ICD9CM 35 365.2 365.20
NCIt 47 C34640
UMLS 69 C0017606

Summaries for Primary Angle-Closure Glaucoma

MalaCards based summary : Primary Angle-Closure Glaucoma, also known as primary angle closure glaucoma, is related to open-angle glaucoma and cataract. An important gene associated with Primary Angle-Closure Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways are FGF signaling pathway and Estrogen metabolism. The drugs Topiramate and Acetazolamide have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related phenotypes are no phenotypic analysis and vision/eye

Related Diseases for Primary Angle-Closure Glaucoma

Diseases related to Primary Angle-Closure Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
id Related Disease Score Top Affiliating Genes
1 open-angle glaucoma 10.6
2 cataract 10.6
3 retinitis 10.3
4 hereditary xanthinuria 10.2 CYP1B1 MYOC
5 red-green color vision defects 10.2 CYP1B1 MYOC
6 baraitser-winter syndrome 10.2 CYP1B1 OPTN
7 multiple cranial nerve palsy 10.2 MFRP OPTN
8 conjunctival folliculosis 10.2 CYP1B1 OPTN
9 ureter cancer 10.2 COL11A1 OPTN
10 mechanical strabismus 10.1 MYOC OPTN
11 neuropathy 10.1
12 pituitary hormone deficiency, combined, 4 10.1 CYP1B1 MYOC OPTN
13 deep keratitis 10.1 COL11A1 OPTN
14 chronic tympanitis 10.1 CYP1B1 MYOC OPTN
15 opisthorchiasis 10.1 CYP1B1 MYOC OPTN
16 peters anomaly 10.1 CYP1B1 MYOC OPTN
17 allergic contact dermatitis of eyelid 10.1 MFRP MYOC OPTN
18 idiopathic corneal edema 10.1 CYP1B1 MYOC OPTN
19 hypertrophy of breast 10.1 CYP1B1 MYOC OPTN
20 nevoid hypermelanosis, linear and whorled 10.0 CYP1B1 MYOC OPTN
21 endotheliitis 10.0
22 aminoaciduria 10.0 MMP9 MTHFR
23 juvenile myelomonocytic leukemia, somatic ptpn11-related 10.0 MFRP VSX2
24 amyotrophic neuralgia 10.0 MFRP OPTN
25 amelogenesis imperfecta, type iia5 10.0 MFRP VSX2
26 cornea plana 9.9
27 choroiditis 9.9
28 entropion 9.9
29 rubeosis iridis 9.9
30 ocular hypertension 9.9
31 refractive error 9.9
32 retinitis pigmentosa 9.9
33 lactocele 9.9 CYP1B1 GSTM1 MYOC OPTN
34 colorectal cancer 5 9.9 CYP1B1 GSTM1 MYOC OPTN
35 anal spasm 9.9 MTHFR VSX2
36 villous adenoma 9.8 GSTM1 MTHFR
37 cornelia de lange syndrome 5 9.8 CYP1B1 MFRP OPTN VSX2
38 acute poststreptococcal glomerulonephritis 8.5 COL11A1 CYP1B1 GSTM1 HGF KERA MFRP

Comorbidity relations with Primary Angle-Closure Glaucoma via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Primary Angle-Closure Glaucoma:



Diseases related to Primary Angle-Closure Glaucoma

Symptoms & Phenotypes for Primary Angle-Closure Glaucoma

MGI Mouse Phenotypes related to Primary Angle-Closure Glaucoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.43 HGF MTHFR MYOC OPTN TXNRD2 VSX2
2 vision/eye MP:0005391 9.17 VSX2 CYP1B1 KERA MFRP MMP9 MTHFR

Drugs & Therapeutics for Primary Angle-Closure Glaucoma

Drugs for Primary Angle-Closure Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 4 97240-79-4 5284627
2
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
3
Pilocarpine Approved Phase 4 54-71-7, 92-13-7 5910
4
Travoprost Approved Phase 4,Phase 3 157283-68-6 5282226
5
Latanoprost Approved, Investigational Phase 4,Phase 3 130209-82-4 5282380 5311221
6
Timolol Approved Phase 4,Phase 3 26839-75-8 33624 5478
7
Brinzolamide Approved Phase 4,Phase 3 138890-62-7 68844
8
Maleic acid Experimental Phase 4 110-16-7 444266
9 Anticonvulsants Phase 4
10 Anti-Obesity Agents Phase 4
11 Neuroprotective Agents Phase 4,Phase 3,Phase 2
12 Protective Agents Phase 4,Phase 3,Phase 2
13 Carbonic Anhydrase Inhibitors Phase 4
14 diuretics Phase 4
15 Natriuretic Agents Phase 4
16 Antihypertensive Agents Phase 4,Phase 3,Phase 2
17 Autonomic Agents Phase 4,Phase 2,Phase 3
18 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
19 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
20 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
21 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3
22 Adrenergic Agents Phase 4,Phase 3,Phase 2
23 Adrenergic Agonists Phase 4,Phase 3,Phase 2
24 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3
25 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
26 Adrenergic Antagonists Phase 4,Phase 3
27 Adrenergic beta-Antagonists Phase 4,Phase 3
28 Anti-Arrhythmia Agents Phase 4,Phase 3
29 Brimonidine Tartrate Phase 4,Phase 3 70359-46-5
30 Cholinergic Agents Phase 4
31 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
32
Glatiramer Acetate Approved, Investigational Phase 3 147245-92-9 3081884
33
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
34
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
35 Tetrahydrozoline Phase 3
36 Adjuvants, Immunologic Phase 3
37 Antirheumatic Agents Phase 3
38 Immunosuppressive Agents Phase 3,Phase 2
39 Alkylating Agents Phase 3
40 Anti-Bacterial Agents Phase 3
41 Antibiotics, Antitubercular Phase 3
42 Mitomycins Phase 3
43 Nucleic Acid Synthesis Inhibitors Phase 3
44 Anti-Inflammatory Agents Phase 2, Phase 3
45 glucocorticoids Phase 2, Phase 3
46 Hormone Antagonists Phase 2, Phase 3
47 Hormones Phase 2, Phase 3
48 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
49 triamcinolone acetonide Phase 2, Phase 3
50 Triamcinolone diacetate Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 56)
id Name Status NCT ID Phase
1 Relationship Between Topiramate Use and Ocular Angle Status Unknown status NCT00153699 Phase 4
2 Combined Phacotube vs Phacotrabeculectomy:A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
3 ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function Unknown status NCT00485238 Phase 4
4 Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG) Completed NCT00762645 Phase 4
5 Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan R® or Travatan Z® Completed NCT00799682 Phase 4
6 Study of Brimonidine and Timolol Ophthalmic Solution With Latanoprost Compared With Latanoprost in Glaucoma Patients Terminated NCT01151904 Phase 4
7 Azopt (Brinzolamide 1.0%) Plus Travatan (Travoprost 0.004%) in Treating Patients With Chronic Angle-Closure Glaucoma (CACG) Terminated NCT00758342 Phase 4
8 Intraocular Pressure (IOP) Lowering Effect of Selective Laser Trabeculoplasty Versus Prostaglandin Analogues in Angle Closure Glaucoma Unknown status NCT01004900 Phase 3
9 Argon Laser Peripheral Iridoplasty for Primary Angle Closure Glaucoma Unknown status NCT00980473 Phase 3
10 Investigating the Neuroprotective Effect of Cop-1 (Copaxone) in Acute Primary Angle Closure Unknown status NCT01936129 Phase 3
11 Oculusgen (Ologen) Glaucoma MMC Control in Estonia Unknown status NCT00524758 Phase 3
12 A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Chronic Angle-Closure Glaucoma Completed NCT00051181 Phase 3
13 Will the Use of Triesence During Glaucoma Surgery Provide Lower Eye Pressure and Improve the Results of the Surgery? Completed NCT00853905 Phase 2, Phase 3
14 Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Not yet recruiting NCT03126968 Phase 2, Phase 3
15 A Study to Assess the Effect of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma Unknown status NCT02152774 Phase 2
16 Use of Topical Euphrasia, a Homeopathic Remedy in Ophthalmology Unknown status NCT02416128 Phase 2
17 Phase IIA Double-Masked Randomized Sham-Controlled Trial of QPI-1007 Delivered by a Single Intravitreal Injection to Subjects With Acute Primary Angle-Closure Glaucoma (APACG) Completed NCT01965106 Phase 2
18 Lucentis for New Onset Neovascular Glaucoma Withdrawn NCT00727038 Phase 1, Phase 2
19 Comparison of Bimatoprost and Latanoprost in Patients With Chronic Angle-Closure Glaucoma: A Randomized Cross-Over Study Unknown status NCT00567788
20 Angle Closure (Glaucoma) in Caucasians Unknown status NCT02054403
21 Optical Coherence Tomography Quantitative Analysis of Changes in Anterior Chamber After Laser Peripheral Lridotomy Unknown status NCT02279472
22 The Genetic Study of Primary Angle-Closure Glaucoma Unknown status NCT00155857
23 Prevalence of Angle Closure in Caucasian Hyperopes Unknown status NCT00823706
24 Protective Effect of Phenytoin on Glaucoma Unknown status NCT00739154
25 Intraocular Pressure Control After Anterior Segment Laser - Comparison Between 2 Drugs Unknown status NCT01417858
26 Prevalence of Glaucoma in the Israeli Arab Population Unknown status NCT01546740
27 Comparison of Phacotrabeculectomy and Trabeculectomy in the Treatment of Primary Angle-closure Glaucoma (PACG) Completed NCT01298635
28 Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma Completed NCT01266343
29 Laser Iridotomy Versus Phacoemulsification in Acute Angle Closure Completed NCT00350428
30 Primary Angle Closure Glaucoma and Aqueous Dynamics Completed NCT00719290
31 Immediate Anterior Chamber Paracentesis With A 30-Gauge Needle for Acute Primary Angle - Closure Completed NCT01923454
32 Comparing Phaco/IOL Versus Phaco/IOL + Goniosynechialysis in Subjects With PACG Completed NCT02376725
33 An Open Label Study Assessing the 24-hour Intraocular Pressure Pattern in PAC and PACG Patients, Before and After Laser Peripheral Iridotomy Completed NCT01906138
34 Comparison of Gonioscopy With Cirrus and Visante Completed NCT01895686
35 Dysphotopsia Following Laser Peripheral Iridotomy Completed NCT01758237
36 Short-term Outcomes of Iridoplasty for Persistent Angle Closure Despite Patent Iridotomies Completed NCT02199158
37 Water Drinking Test in Patients With Occludable Angle Completed NCT02613533
38 Prospective Evaluation of the Efficacy of Pascal Laser Iridotomy and Pascal Laser Peripheral Iridoplasty: A Pilot Study Completed NCT01020071
39 Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study Completed NCT00452998
40 Role of Polymorphisms in the IL-1 Gene Cluster Completed NCT00346541
41 Will Listening to Music Make it Easier to Take a Visual Field Test? Completed NCT01027039
42 The Effect of Ocular Massage on the Management of Elevated Intraocular Pressure After Acute Angle Closure Completed NCT02539758
43 Cataract Surgery vs Cataract Surgery With ECPL for Treatment of Plateau Iris Configuration or Syndrome Completed NCT02049333
44 Laser Peripheral Iridotomy Plus Laser Peripheral Iridoplasty for Primary Angle Closure Recruiting NCT02613013
45 Comparing Nd:YAG Laser and Sequential Double Frequency YAG-Nd:YAG Laser Iridotomy Recruiting NCT02474238
46 Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot Study Recruiting NCT02865473
47 Longitudinal Study on Glaucoma Surgery Using XEN® Gel Stent Active, not recruiting NCT03151577
48 Advanced Glaucoma Progression Study Active, not recruiting NCT01742819
49 Clinical Study of LPI on Different Sites of Iris Active, not recruiting NCT02870504
50 Clinical Study of LPI With Different Laser Wavelengths Active, not recruiting NCT02901730

Search NIH Clinical Center for Primary Angle-Closure Glaucoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Primary Angle-Closure Glaucoma

Anatomical Context for Primary Angle-Closure Glaucoma

MalaCards organs/tissues related to Primary Angle-Closure Glaucoma:

39
Eye, Testes, Endothelial, Retina, Brain

Publications for Primary Angle-Closure Glaucoma

Articles related to Primary Angle-Closure Glaucoma:

(show top 50) (show all 362)
id Title Authors Year
1
Evaluation of potential risk factors for development of primary angle-closure glaucoma in Bouviers des Flandres. ( 28001106 )
2017
2
Early lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma: an economic evaluation based on data from the EAGLE trial. ( 28087548 )
2017
3
The association between serum uric acid and glaucoma severity in primary angle closure glaucoma: a retrospective case-control study. ( 27926530 )
2016
4
Factors affecting refractive outcome after cataract surgery in primary angle-closure glaucoma: methodological issues of prediction model. ( 27526198 )
2016
5
Erratum. Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma. ( 26943150 )
2016
6
Limbus-insertion distance of superior rectus in primary angle closure glaucoma: an anterior segment OCT study. ( 27938955 )
2016
7
Trabeculectomy and Combined Phacoemulsification-Trabeculectomy: Outcomes and Risk Factors for Failure in Primary Angle Closure Glaucoma. ( 27513900 )
2016
8
Re: Narayanaswamy etA al.: Argon laser peripheral iridoplasty for primary angle-closure glaucoma: a randomized controlled trial (Ophthalmology 2016;123:514-21). ( 27450829 )
2016
9
Impact of Socioeconomic Status on the Diagnosis of Primary Open-Angle Glaucoma and Primary Angle Closure Glaucoma: A Nationwide Population-Based Study in Taiwan. ( 26905307 )
2016
10
Intra-ocular pressure fluctuation after cataract surgery in primary angle-closure glaucoma eyes medically controlled after laser iridotomy. ( 27040022 )
2016
11
Evaluation of Ex-PRESS implantation combined with phacoemulsification in primary angle-closure glaucoma. ( 27603352 )
2016
12
Phacoemulsification versus combined phacotrabeculectomy in the treatment of primary angle-closure glaucoma with cataract: a Meta-analysis. ( 27162736 )
2016
13
Patient-Reported Vision-Related Quality-of-Life Differences between Primary Angle-Closure Glaucoma and Primary Open-Angle Glaucoma. ( 27690232 )
2016
14
Pattern of Visual Field Loss in Primary Angle-Closure Glaucoma Across Different Severity Levels. ( 27423311 )
2016
15
Factors affecting refractive outcome after cataract surgery in primary angle-closure glaucoma. ( 27082207 )
2016
16
Primary angle closure glaucoma: What we know and what we don't know. ( 28039061 )
2016
17
Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial. ( 27707497 )
2016
18
[Association of PLEKHA7, COL11A1 and PCMTD1-ST18 gene polymorphisms with primary angle closure glaucoma in ethnic Han Chinese from Sichuan]. ( 27455018 )
2016
19
Trends in Acute Primary Angle-Closure Glaucoma, Peripheral Iridotomy and Cataract Surgery in Scotland, 1998-2012. ( 26751514 )
2016
20
Primary angle-closure glaucoma: A retrospective interventional case series in South India. ( 27013823 )
2016
21
Managing Primary Angle Closure Glaucoma - The Role of Lens Extraction in this Era. ( 27014390 )
2016
22
Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. ( 27064256 )
2016
23
Factors affecting refractive outcome after cataract surgery in primary angle-closure glaucoma: methodological issues of prediction model - response. ( 27526301 )
2016
24
Management of Primary Angle-Closure Glaucoma. ( 26886121 )
2016
25
Argon Laser Peripheral Iridoplasty for Primary Angle-Closure Glaucoma: A Randomized Controlled Trial. ( 26707418 )
2016
26
Anterior segment imaging-based subdivision of subjects with primary angle-closure glaucoma. ( 27935603 )
2016
27
Association of Matrix Metalloproteinase-9 (MMP9) Variants with Primary Angle Closure and Primary Angle Closure Glaucoma. ( 27272641 )
2016
28
Selective Laser Trabeculoplasty in Primary Angle-closure Glaucoma After Laser Peripheral Iridotomy: A Case-Control Study. ( 26945310 )
2016
29
Verification of a formula developed to predict the postoperative intraocular pressure after cataract surgery in primary angle-closure glaucoma. ( 27686500 )
2016
30
The role of lens extraction in the current management of primary angle-closure glaucoma. ( 25565368 )
2015
31
A Novel KERA Mutation in a Case of Autosomal Recessive Cornea Plana With Primary Angle-Closure Glaucoma. ( 25967529 )
2015
32
Guidelines for treatment of chronic primary angle-closure glaucoma. ( 25459683 )
2015
33
Plateau iris in Japanese patients with primary angle closure and primary angle closure glaucoma. ( 26170608 )
2015
34
Efficacy And Safety of Surgical Treatment Options for Primary Angle Closure Glaucoma: a Meta-Analysis of Randomised Controlled Trials. ( 26532341 )
2015
35
Genetic associations in PLEKHA7 and COL11A1 with primary angle closure glaucoma: a meta-analysis. ( 25732101 )
2015
36
Primary angle-closure glaucoma: an update. ( 26119516 )
2015
37
Disturbed spontaneous brain activity pattern in patients with primary angle-closure glaucoma using amplitude of low-frequency fluctuation: a fMRI study. ( 26251603 )
2015
38
Swept-source optical coherence tomography assessment of iris-trabecular contact after phacoemulsification with or without goniosynechialysis in eyes with primary angle closure glaucoma. ( 25573150 )
2015
39
The Impact of Lens Vault on Visual Acuity and Refractive Error: Implications for Management of Primary Angle-Closure Glaucoma. ( 25943738 )
2015
40
Evolving Paradigms in Classification of Primary Angle Closure Glaucoma. ( 26292158 )
2015
41
A Possible Role for LTBP2 in the Etiology of Primary Angle Closure Glaucoma. ( 26425313 )
2015
42
Effects of Phacoemulsification Combined With Goniosynechialysis on Primary Angle-closure Glaucoma. ( 26066498 )
2015
43
A Study on the Central Corneal Thickness of Primary Angle Closure and Primary Angle Closure Glaucoma and Its Effect on Visual Field Progression. ( 26065503 )
2015
44
The genetic mechanisms of primary angle closure glaucoma. ( 26206529 )
2015
45
Network Centrality of Resting-State fMRI in Primary Angle-Closure Glaucoma Before and After Surgery. ( 26506229 )
2015
46
Is the GSTM1 null polymorphism a risk factor for primary angle-closure glaucoma among Iranian population? ( 25725180 )
2015
47
Plateau Iris in Primary Angle Closure Glaucoma: An Ultrasound Biomicroscopy Study. ( 25943727 )
2015
48
Circadian Intraocular Pressure Fluctuation and Disease Progression in Primary Angle Closure Glaucoma. ( 26230764 )
2015
49
Evaluation of the Association Between Common Genetic Variants Near the ABCA1 Gene and Primary Angle Closure Glaucoma in a Han Chinese Population. ( 26431478 )
2015
50
Lack of Association Between Corneal Hysteresis and Corneal Resistance Factor With Glaucoma Severity in Primary Angle Closure Glaucoma. ( 26517405 )
2015

Variations for Primary Angle-Closure Glaucoma

Expression for Primary Angle-Closure Glaucoma

Search GEO for disease gene expression data for Primary Angle-Closure Glaucoma.

Pathways for Primary Angle-Closure Glaucoma

Pathways related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.83 HGF MMP9
2
Show member pathways
10.49 CYP1B1 GSTM1
3 9.85 HGF MMP9

GO Terms for Primary Angle-Closure Glaucoma

Cellular components related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.92 COL11A1 KERA MMP9 MYOC

Biological processes related to Primary Angle-Closure Glaucoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 collagen fibril organization GO:0030199 9.26 COL11A1 CYP1B1
2 endodermal cell differentiation GO:0035987 9.16 COL11A1 MMP9
3 positive regulation of cell migration GO:0030335 9.13 HGF MMP9 MYOC
4 visual perception GO:0007601 9.02 COL11A1 CYP1B1 KERA MFRP VSX2

Sources for Primary Angle-Closure Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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