MCID: PRM024
MIFTS: 40

Primary Angle-Closure Glaucoma malady

Eye category

Summaries for Primary Angle-Closure Glaucoma

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33MalaCards
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MalaCards: Primary Angle-Closure Glaucoma, also known as primary angle-closure glaucoma, unspecified, is related to primary open angle glaucoma and blindness. An important gene associated with Primary Angle-Closure Glaucoma is MYOC (myocilin, trabecular meshwork inducible glucocorticoid response), and among its related pathways are Syndecan-1-mediated signaling events and EPHA2 forward signaling. The compounds vitamin d and hydroxyproline have been mentioned in the context of this disorder. Related mouse phenotypes are integument and cardiovascular system.

Aliases & Classifications for Primary Angle-Closure Glaucoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 27ICD9CM, 61UMLS, 57SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

primary angle-closure glaucoma 8 10 45
primary angle-closure glaucoma, unspecified 8
unspecified primary angle-closure glaucoma 8
primary angle-closure glaucoma, nos 8
primary angle-closure glaucoma nos 8
primary angle closure glaucoma 8


External Ids:

Disease Ontology8 DOID:1405
ICD9CM27 365.20, 365.2
NCIt40 C34640
ICD1025 H40.2

Related Diseases for Primary Angle-Closure Glaucoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Primary Angle-Closure Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1primary open angle glaucoma31.5OPTN, MYOC, CYP1B1
2blindness30.6MYOC, OPA1, OPTN
3cataract-glaucoma10.9
4lens subluxation10.3
5retinitis pigmentosa10.3
6ocular hypertension10.3
7rubeosis iridis10.3
8glaucoma, hereditary10.3
9cataract 1910.3
10hyperopia10.3
11amyotrophic lateral sclerosis10.0OPTN
12myopia 610.0MYOC
13moyamoya disease10.0PCMTD1
14primary congenital glaucoma10.0CYP1B1
15periodontitis10.0MMP9
16primary open angle glaucoma juvenile onset 110.0MYOC, CYP1B1
17hypercholesterolemia10.0LDLR
18stroke, ischemic10.0MTHFR
19low tension glaucoma10.0OPTN, OPA1
20oral cancer10.0CYP1B1, MMP9
21aortic disease10.0LDLR
22proliferative diabetic retinopathy10.0MMP9, HGF
23leber hereditary optic neuropathy10.0MYOC, OPA1
24glaucoma 3, primary congenital, d10.0CYP1B1, MYOC, OPTN
25optic nerve disease10.0MYOC, OPA1, OPTN
26hypertension10.0MMP9, MTHFR
27wilms tumor10.0SPARC
28cataract10.0CTSA, MYOC, SPARC
29multiple sclerosis10.0MMP9
30glioblastoma multiforme10.0HGF, CALCRL, MMP9
31myocardial infarction10.0LDLR, MTHFR
32ischemia10.0HGF, CALCRL, NTF4
33arthritis10.0MMP9
34antiphospholipid syndrome10.0MTHFR, LDLR
35adenoma10.0MTHFR, CYP1B1, LDLR
36idiopathic pulmonary fibrosis10.0HGF, MMP9, SPARC
37open-angle glaucoma10.0CYP1B1, MYOC, OPA1, OPTN, LOXL1
38migraine10.0LDLR, MTHFR, CALCRL
39pancreatic cancer10.0HGF, CALCRL, MMP9, SPARC
40osteosarcoma10.0CALCRL, MMP9, SPARC, LDLR
41arteriosclerosis10.0LDLR, MTHFR, HGF
42coronary artery disease,10.0LDLR, SPARC, MMP9, MTHFR
43glaucoma10.0CYP1B1, MYOC, NTF4, OPA1, OPTN, CTSA
44malignant glioma10.0HGF, CALCRL, CYP1B1, MMP9, SPARC
45atherosclerosis10.0MTHFR, MMP9, SPARC, LDLR
46kidney cancer10.0SPARC, MMP9, CYP1B1, HGF
47pulmonary fibrosis10.0SPARC, MMP9, HGF
48melanoma10.0HGF, CTSA, NTF4, CYP1B1, MMP9, SPARC
49prostate cancer10.0LDLR, SPARC, MMP9, VAV3, CYP1B1, HGF

Graphical network of the top 20 diseases related to Primary Angle-Closure Glaucoma:



Diseases related to primary angle-closure glaucoma

Clinical Features for Primary Angle-Closure Glaucoma

Drugs & Therapeutics for Primary Angle-Closure Glaucoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Primary Angle-Closure Glaucoma

Search CenterWatch for Primary Angle-Closure Glaucoma

Genetic Tests for Primary Angle-Closure Glaucoma

Anatomical Context for Primary Angle-Closure Glaucoma

Animal Models for Primary Angle-Closure Glaucoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Primary Angle-Closure Glaucoma

Sources:
51PubMed
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Articles related to Primary Angle-Closure Glaucoma:

(show top 50)    (show all 291)
idTitleAuthorsYear
1
Efficacy of prophylactic antiglaucoma and anti-inflammatory medications in canine primary angle-closure glaucoma: a multicenter retrospective study (2004-2012). (23826812)
2013
2
Goniosynechialysis Using an Ophthalmic Endoscope and Cataract Surgery for Primary Angle-closure Glaucoma. (23708423)
2013
3
Comparison of anterior segment optical coherence tomography and ultrasound biomicroscopy for iris parameter measurements in patients with primary angle closure glaucoma. (24404660)
2013
4
Comparison of Ocular Biometry Between Eyes With Chronic Primary Angle-Closure Glaucoma and their Fellow Eyes With Primary Angle-Closure or Primary Angle-Closure Suspect. (23807358)
2013
5
Retinal dystrophy and primary angle-closure glaucoma. (23563704)
2013
6
Genotype-phenotype analysis of SNPs associated with primary angle closure glaucoma (rs1015213, rs3753841 and rs11024102) and ocular biometry in the EPIC-Norfolk Eye Study. (23505305)
2013
7
Killing two birds with one stone: the potential effect of cataract surgery on the incidence of primary angle-closure glaucoma in a high-risk population. (21668793)
2012
8
Susceptibility to primary angle closure glaucoma in Saudi Arabia: the possible role of mitochondrial DNA ancestry informative haplogroups. (21850192)
2011
9
Ultrasound biomicroscopic assessment of angle parameters in patients with primary angle closure glaucoma undergoing phacoemulsification. (21279978)
2011
10
Outcomes of primary angle closure glaucoma management. (22204235)
2011
11
Primary angle-closure glaucoma is a multifactorial disease. (22452677)
2011
12
Pharmacological and environmental factors in primary angle-closure glaucoma. (19933218)
2010
13
Damage to the blood-aqueous barrier in eyes with primary angle closure glaucoma. (21042429)
2010
14
Phacoemulsification alone versus phacoemulsification combined with trabeculectomy for primary angle-closure glaucoma. (20635456)
2010
15
Damage patterns of retinal nerve fiber layer in acute and chronic intraocular pressure elevation in primary angle closure glaucoma. (22553541)
2010
16
Getting the red out: primary angle-closure glaucoma. (19390391)
2009
17
Recovery of corneal hysteresis after reduction of intraocular pressure in chronic primary angle-closure glaucoma. (19782799)
2009
18
Comparing glaucomatous optic neuropathy in primary open angle and primary angle closure glaucoma eyes by scanning laser polarimetry-variable corneal compensation. (18344755)
2008
19
Confirmation of the presence of uveal effusion in Asian eyes with primary angle closure glaucoma: an ultrasound biomicroscopy study. (19064843)
2008
20
Molecular analysis of CHX10 and MFRP in Chinese subjects with primary angle closure glaucoma and short axial length eyes. (18648522)
2008
21
Ultrasound biomicroscopic quantification of the change in anterior chamber angle following laser peripheral iridotomy in early chronic primary angle closure glaucoma. (16543925)
2007
22
The plateau iris component of primary angle closure glaucoma: developmental or acquired. (17222990)
2007
23
An evaluation of the darkroom prone provocative test in family members of primary angle closure glaucoma patients. (16710437)
2007
24
Primary angle-closure glaucoma. (17467539)
2007
25
Prevention of primary angle-closure glaucoma in Asia. (17576702)
2007
26
Distribution and characteristics of peripheral anterior synechiae in primary angle-closure glaucoma. (16892646)
2006
27
Comparison of glaucomatous optic nerve damage in primary angle-closure glaucoma with and without acute attack. (16209282)
2005
28
Utility values in Singapore Chinese adults with primary open-angle and primary angle-closure glaucoma. (16276277)
2005
29
Crossover comparison of timolol and latanoprost in chronic primary angle-closure glaucoma. (14769594)
2004
30
Screening for primary angle closure in Mongolia: a randomised controlled trial to determine whether screening and prophylactic treatment will reduce the incidence of primary angle closure glaucoma in an east Asian population. (12598435)
2003
31
Gonioscopy in primary angle closure glaucoma. (15513458)
2002
32
Epidemiology of acute primary angle-closure glaucoma in the Hong Kong Chinese population: prospective study. (11514744)
2001
33
Detection of gonioscopically occludable angles and primary angle closure glaucoma by estimation of limbal chamber depth in Asians: modified grading scheme. Foster PJ, Devereux JG, Alsbirk PH, Pak Lee PS, Uranchimeg D, Machin D, Johnson GJ,*(1) Baasanhu J. Br J Ophthalmol 2000;84:186-192. (11341883)
2001
34
Detection of gonioscopically occludable angles and primary angle closure glaucoma by estimation of limbal chamber depth in Asians: modified grading scheme. (10655196)
2000
35
Comparison of symptomatic and asymptomatic, chronic, primary angle-closure glaucoma, open-angle glaucoma, and controls. (10877370)
2000
36
Outcome of laser peripheral iridotomy in chronic primary angle closure glaucoma. (10929978)
1999
37
Primary angle-closure glaucoma in India. (9672302)
1998
38
Biometric study of acute primary angle-closure glaucoma. (9409125)
1997
39
A history of primary angle closure glaucoma. (8533105)
1995
40
The role of ethnicity in primary angle-closure glaucoma. (7839287)
1994
41
Presenting features of primary angle-closure glaucoma in patients of mixed ethnic background. (8211524)
1993
42
Primary angle-closure glaucoma and mononuclear blindness. Clinical pattern in 2 Inuit women from Greenland. (1622533)
1992
43
The association of iridoschisis and primary angle-closure glaucoma. (1446758)
1992
44
The clinical course in primary angle-closure glaucoma: a reassessment. (3730919)
1986
45
The endothelium in primary angle-closure glaucoma. (6742065)
1984
46
Peripheral iridectomy in primary angle closure glaucoma. (6671774)
1983
47
Argon laser peripheral iridotomies in the treatment of primary angle closure glaucoma. Long-term follow-up. (7092629)
1982
48
Management of primary angle-closure glaucoma. (7216639)
1981
49
Management of acute primary angle-closure glaucoma: a long-term follow-up of the results of peripheral iridectomy used as an initial procedure. (760771)
1979
50
Central corneal thickness. Ocular correlations in normal eyes and those with primary angle-closure glaucoma. (5386371)
1969

Genetic Variations for Primary Angle-Closure Glaucoma

Expression for genes affiliated with Primary Angle-Closure Glaucoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Primary Angle-Closure Glaucoma

Search GEO for disease gene expression data for Primary Angle-Closure Glaucoma.

Pathways for genes affiliated with Primary Angle-Closure Glaucoma

Sources:
38NCBI BioSystems Database, 30KEGG
See all sources

Pathways related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MMP9, HGF
29.9VAV3, VAV2
39.7MMP9, VAV3, VAV2

Compounds for genes affiliated with Primary Angle-Closure Glaucoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1vitamin d4510.3HGF
2hydroxyproline45 11 2412.0HGF, MMP9, SPARC
3cyclophosphamide45 50 1112.0HGF, MTHFR, CYP1B1, MMP9
4doxycycline45 1111.0CYP1B1, MMP9, SPARC
5sele459.9LDLR, MTHFR
6carbon459.9LDLR, CYP1B1, MTHFR, HGF
7folate459.9HGF, MTHFR, MMP9, LDLR
8p002459.9MMP9, CYP1B1, MTHFR
9lactacystin459.9MMP9, CTSA, HGF
10serine459.8LDLR, MMP9, VAV2, CYP1B1
11ascorbic acid45 2410.7HGF, MTHFR, MYOC, SPARC, LDLR
12genistein45 29 60 2 11 2414.6HGF, CYP1B1, MMP9, SPARC, LDLR
13cycloheximide459.6LDLR, MMP9, CYP1B1, MYOC, HGF
14adenylate459.6HGF, CALCRL, NTF4, CYP1B1, MMP9, LDLR
15alpha tocopherol459.5MTHFR, MMP9, LDLR
16alanine459.5HGF, MTHFR, NTF4, MYOC, MMP9, LDLR
17glutamate459.5HGF, MTHFR, NTF4, CYP1B1, MMP9, LDLR
18retinoic acid45 2410.3HGF, MTHFR, NTF4, CYP1B1, MMP9, SPARC
19testosterone45 60 11 2412.2HGF, MTHFR, CYP1B1, VAV3, MMP9, SPARC
20dexamethasone45 50 29 1112.1LDLR, HGF, CALCRL, OPTN, MYOC, CYP1B1

GO Terms for genes affiliated with Primary Angle-Closure Glaucoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Primary Angle-Closure Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of release of cytochrome c from mitochondriaGO:09020110.1OPA1, HGF
2angiogenesisGO:0015259.4VAV3, VAV2, CYP1B1, CALCRL
3platelet activationGO:0301689.1HGF, VAV2, VAV3, SPARC

Products for genes affiliated with Primary Angle-Closure Glaucoma

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  • Lysates
  • Antibodies

Sources for Primary Angle-Closure Glaucoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet