Primary Biliary Cirrhosis malady

NIH Rare Diseases: Primary biliary cirrhosis is a chronic disease that affects the bile ducts within the liver. The bile ducts become inflamed and damaged, which causes bile to build up in the liver. This abnormal buildup destroys liver tissue and results in cirrhosis. Primary biliary cirrhosis usually occurs between the ages of 40 and 60 and affects women more often than men. The cause of this condition is unknown, but research suggests that it is an autoimmune disease. Ursodiol is the only drug approved by the U.S. Food and Drug Administration for the treatment of primary biliary cirrhosis.³⁰

MalaCards: Primary Biliary Cirrhosis, also known as biliary cirrhosis, is related to liver cirrhosis and hepatitis. An important gene associated with Primary Biliary Cirrhosis is DLAT (dihydrolipoamide S-acetyltransferase), and among its related pathways are Cell adhesion molecules (CAMs) and Immune System. The drugs colchicine and penicillamine and the compounds phosphorus and glucose have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and heart, and related mouse phenotypes are hematopoietic system and respiratory system.

Wikipedia: Primary biliary cirrhosis, often abbreviated PBC, is an autoimmune disease of the liver marked by the...⁴⁴ more...

Aliases & Descriptions:

primary biliary cirrhosis 6 30 8 43 biliary cirrhosis 6 32 43 chronic non-suppurative destructive cholangitis 6 chronic nonsuppurative destructive cholangitis 6 primary biliary cirrhosis (disorder) 6 familial primary biliary cirrhosis 30

biliary cirrhosis nos (disorder) 6 biliary cirrhosis (disorder) 6 biliary cirrhosis primary 32 cirrhosis, cholestatic 6 cirrhosis 43 pbc 30

Disease types for primary biliary cirrhosis family:

biliary cirrhosis, primary, 2	biliary cirrhosis, primary, 3

Diseases related to primary biliary cirrhosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 983)

id	Related Disease	Score	Top Affiliating Genes
1	liver cirrhosis	38.2	RETN, CNR1, CNR2, SEPSECS, CD14, GPT
2	hepatitis	37.5	GPT, IFNA1, TIMP1, SOD2, SLC17A5
3	autoimmune hepatitis	36.4	PDCD1, SEPSECS, CD14, CD40LG, GSTT1, GPT
4	primary sclerosing cholangitis	36.1	MPO, ENO1, GPT, HLA-A, DLAT, NR1I2
5	alcoholic liver cirrhosis	35.9	GSTM1, GPT, F2, ALB, CYP2E1, LSL
6	sclerosing cholangitis	34.4	SEPSECS, LBR, ATG16L1, MPO, CD79A, CD86
7	cholangitis	34.2	PCNA, SEPSECS, LBR, ATM, ATG16L1, MPO
8	rheumatoid arthritis	33.7	IL1RN, MBL2, HLA-DRB1, TNFRSF1A, SRF, LTA
9	alcoholism	32.9	CNR1, LBR, IL1RN, GPT, GHRL, CYP2E1
10	portal hypertension	32.9	RETN, CNR1, GPT, F2, ALB, NOS3
11	arthritis	32.4	SELL, IL17A, IL1B, IL6, TNF, TNFRSF1A
12	hemochromatosis	31.7	B2M, MR1, CALR, HP, HLA-B, CP
13	acute liver failure	31.6	GPT, F2, ALB, SLC17A5, CP, HGF
14	connective tissue disease	31.1	BMP6, CENPB, CD36, ENO1, HSPD1, CALR
15	polymyositis	30.9	PIK3C2A, CD86, CD180, CD80, ITGA4, GZMB
16	multiple sclerosis	30.5	CLEC16A, CD14, IL12A, IL1B, IL1RN, IL2RA
17	hepatitis b	30.3	PDCD1, IL10, IL17A, IL2RA, MBL2, CCR5
18	takayasu's arteritis	30.3	LBR, CD40LG, IL12A, IL2, IL6, IL6R
19	alcoholic hepatitis	30.3	IL10, ICAM1, F2, TNF, CYP2E1, HGF
20	hepatitis c	30.1	CIITA, CD40LG, IL10, IL2, IL6R, CCL8
21	cholestasis	29.8	CNR1, RDX, PCNA, SEPSECS, BGLAP, BCL2
22	portal vein thrombosis	29.7	PCNA, IFNA1, IFNA2, F3, F2, ALB
23	cholelithiasis	29.5	SCARB1, CD79A, CD40LG, INS, APOE, GPT
24	intrahepatic cholangiocarcinoma	29.5	SELL, BCL2, MUC1, MKI67, GSDMB, GSTP1
25	hemolytic anemia	29.5	MPO, CD40LG, IL10, IL17A, IL2, IL2RA
26	crohn's disease	29.2	MPO, CD80, FOXP3, IL10, IL12RB2, IL17A
27	hyperhomocysteinemia	29.2	UCP2, CETP, INS, IL1B, IL1RN, IL6
28	disseminated intravascular coagulation	29.1	PIK3C2A, MPO, CD14, CD40LG, FN1, IL10
29	iron overload	28.9	VDR, BMP6, B2M, INS, GSTM1, IMMT
30	inflammatory bowel disease	28.4	RETN, SELL, VDR, BGLAP, CIITA, MPO
31	pulmonary function	28.4	LEP, MPO, CD36, CD14, INS, GSTM1
32	sepsis	28.1	RETN, SELL, CIITA, MPO, CD14, ITGA4
33	galactosemia	28.0	GPT, F3, F2, ALB, CYP3A4, EDN3
34	primary hyperparathyroidism	27.7	VDR, BGLAP, CD36, ALPP, CALCA, ACP5
35	blindness	27.6	PIK3C2A, CNR1, VDR, BGLAP, LEP, UCP2
36	peptic ulcer	27.6	CD79A, CD14, ITGA4, GZMB, IL10, IL1B
37	fatty liver disease	27.6	RETN, CNR1, LEP, UCP2, CETP, CD36
38	pulmonary hypertension	27.5	PIK3C2A, PCNA, BMP6, B2M, CD36, CD40LG
39	protein-energy malnutrition	27.4	LEP, MPO, CD79A, GPT, IGF1, ALB
40	porphyria cutanea tarda	27.3	SEPSECS, BMP6, CD36, GSTM1, GSTT1, IFNA1
41	wilson disease	27.3	B2M, ATOX1, CD79A, IL1B, IL1RN, IL6
42	alpha 1-antitrypsin deficiency	27.3	SEPSECS, BMP6, MPO, CD14, GSTP1, IL10
43	cryoglobulinemia	27.3	BMP6, BCL2, CD79A, CD27, CD40LG, FN1
44	thrombocytopenia	27.2	PIK3C2A, SELL, BMP6, CD79A, CDKN1A, CD36
45	alcohol abuse	27.2	B2M, CETP, GPT, HP, CYP2E1, NR3C1
46	hepatitis e	27.2	CD40LG, GPT, IFNA1, IFNA2, IFNG, F2
47	viral hepatitis	27.0	PCNA, SEPSECS, BGLAP, LEP, B2M, MPO
48	cholangiocarcinoma	26.9	PCNA, SELL, VDR, BMI1, BMP6, BCL2
49	tuberculosis	26.4	VDR, IL10, IL1B, IL1RN, MBL2, IFNG
50	retinol binding protein	26.2	RETN, LEP, B2M, MKI67, INS, ALB

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 colchcine, colchicine, penicillamine, ursodiol

Cell-based therapeutics:

MalaCards organs/tissues related to primary biliary cirrhosis:

²²

MGI Mouse Phenotypes related to primary biliary cirrhosis:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.9	PDCD1, KIFC3, PCNA, BMI1, BCL2, ATM
2	respiratory system phenotype	MP:0005388	10.6	SELL, NAB1, UCP2, ATOX1, CD14, CD1D
3	endocrine/exocrine gland phenotype	MP:0005379	10.1	REG1A, SELL, CENPB, ATG16L1, CD40LG, IL2
4	embryogenesis phenotype	MP:0005380	9.9	BMI1, SCARB1, ATM, ITGA4, ITGAV, IL5
5	immune system phenotype	MP:0005387	9.8	CNR2, SELL, VDR, BMI1, SCARB1, CIITA
6	integument phenotype	MP:0010771	9.2	CNR1, CNR2, NAB1, BCL2, MUC1, LBR
7	normal phenotype	MP:0002873	9.1	NAB1, CIITA, LAMP1, CENPB, CD79A, CD4
8	liver/biliary system phenotype	MP:0005370	9.0	RETN, RDX, ATOX1, CD36, CD1D, INS
9	other phenotype	MP:0005395	9.0	CNR1, ATOX1, CD40LG, FN1, IL2, APOA2
10	limbs/digits/tail phenotype	MP:0005371	8.9	VDR, BMI1, LEP, LBR, FN1, IL10
11	renal/urinary system phenotype	MP:0005367	8.8	PDCD1, KIFC3, BCL2, CDKN1A, CD180, CD1D
12	nervous system phenotype	MP:0003631	8.7	PDCD1, CNR1, RDX, RBFOX1, NAB1, VCP
13	no phenotypic analysis	MP:0003012	8.6	CNR1, PCNA, MUC1, LBR, ATM, CD79A
14	mortality/aging	MP:0010768	7.9	PIK3C2A, PDCD1, CNR1, RBFOX1, NAB1, VDR
15	reproductive system phenotype	MP:0005389	7.9	REG1A, RBFOX1, NAB1, VDR, SCARB1, LEP
16	skeleton phenotype	MP:0005390	7.3	CNR1, NAB1, VDR, VCP, BMI1, BMP6
17	digestive/alimentary phenotype	MP:0005381	7.0	VDR, BMI1, BCL2, LEP, MUC1, LBR
18	growth/size phenotype	MP:0005378	7.0	PIK3C2A, CNR1, RBFOX1, NAB1, VDR, BMI1
19	behavior/neurological phenotype	MP:0005386	6.5	CNR1, RDX, RBFOX1, NAB1, VCP, BMI1
20	vision/eye phenotype	MP:0005391	6.2	PDCD1, KIFC3, BMI1, BCL2, LEP, MUC1
21	adipose tissue phenotype	MP:0005375	5.9	PIK3C2A, RETN, CNR1, BCL2, LEP, LBR
22	cellular phenotype	MP:0005384	5.8	PDCD1, CNR1, PCNA, SELL, NAB1, VDR
23	muscle phenotype	MP:0005369	5.6	PDCD1, VCP, BCL2, LEP, MPO, CDKN1A
24	tumorigenesis	MP:0002006	5.4	SELL, BMI1, BCL2, LEP, MUC1, B2M
25	homeostasis/metabolism phenotype	MP:0005376	5.3	PIK3C2A, REG1A, RETN, CNR1, RDX, RBFOX1
26	cardiovascular system phenotype	MP:0005385	4.5	PDCD1, SELL, VDR, BMI1, BCL2, SCARB1

Articles related to primary biliary cirrhosis:

(show top 50)    (show all 451)

id	Title	Authors	Year	Affiliating Genes
1	Genome-wide association study identifies 12 new susce ptibility loci for primary biliary cirrhosis. (21399635)	Mells G.F.... Anderson C.A.	2011	NFKB1, TNFRSF1A, RPS6KA4
2	Catalytic domain of PDC-E2 contains epitopes recogniz ed by antimitochondrial antibodies in primary biliary cirrhosis. (20180236)	Braun S.... Klein R.	2010	DLAT
3	Analysis of HLA-DRB1 polymorphisms in Japanese patien ts with primary biliary cirrhosis (PBC): The HLA-DRB1polymorphism determines th e relative risk of antinuclear antibodies for disease progression in PBC. (20374297)	Nakamura M.... Ishibashi H.	2010	HLA-DRB1
4	Association analysis of cytotoxic T-lymphocyte antige n 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients. (20557968)	Joshita S.... Ota M.	2010	CTLA4
5	B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. (19118554)	Moritoki Y.... Lian Z.X.	2009	TNF, IL6
6	Portal hypertension and primary biliary cirrhosis: ef fect of long-term ursodeoxycholic acid treatment. (18722374)	Huet P.M.... Huet-van Kerckvoorde J.	2008	SLC17A5
7	Multidrug resistance 1 genotype and disposition of budesonide in early primary biliary cirrhosis. (16584389)	Dilger K.... Beuers U.	2006	CYP3A4, CYP3A5, ABCB1
8	Analysis of HLA alleles polymorphism in Chinese patients with primary biliary cirrhosis. (16481299)	Liu H.Y.... Zhong R.Q.	2006	HLA-A, HLA-DRB1
9	Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice. (16849474)	Oertelt S.... Gershwin M.E.	2006	TGFBR2
10	A retrospective study on clinical features and prognostic factors of biopsy-proven primary biliary cirrhosis in Chinese patients. (16181370)	Wong G.L.... Chan H.L.	2005	ALB
11	Th1 cytokine-induced downregulation of PPARgamma in human biliary cells relates to cholangitis in primary biliary cirrhosis. (15880426)	Harada K.... Nakanuma Y.	2005	PPARG
12	Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis. (16006099)	Wang A.P.... Ishibashi H.	2005	TLR4
13	Genetic association of vitamin D receptor polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese. (15683428)	Fan L.... Zhong R.	2005	VDR
14	Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis. (16093869)	Szalay F.... Lakatos P.L.	2005	LEP
15	Primary biliary cirrhosis is characterized by IgG3 antibodies cross-reactive with the major mitochondrial autoepitope and its Lactobacillus mimic. (16025495)	Bogdanos D.P.... Vergani D.	2005	DLAT
16	Extensive homology between the major immunodominant mitochondrial antigen in primary biliary cirrhosis and Helicobacter pylori does not lead to immunological cross-reactivity. (15513338)	Bogdanos D.P.... Vergani D.	2004	DLAT
17	Insulin-like growth factor I gene microsatellite repeat, collagen type Ialpha1 gene Sp1 polymorphism, and bone disease in primary biliary cirrhosis. (15256976)	Lakatos P.L.... Szalay F.	2004	IGF1, COL1A1
18	Efficacy of combined administration of ursodeoxychol ic acid and hepthral in the treatment of primary biliary cirrhosis (15114777)	Avezov S.A.... Mansurov F.K.h.	2004	GGT1
19	Genetic association of tumor necrosis factor (TNF)-alpha polymorphisms with primary biliary cirrhosis and autoimmune liver diseases in a Chinese population (15059302)	Fan L.Y.... Zhou L.	2004	TNF
20	Natural history of primary biliary cirrhosis. (14594131)	ParAcs A.... RodAcs J.	2003	F2, ALB
21	Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. (14578864)	Selmi C.... Gershwin M.E.	2003	DLAT
22	Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis. (14598254)	Kamihira T.... Harada M.	2003	DLAT
23	Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 protein and messenger RNA in primary biliary cirrhosis. (14606706)	Yokomori H.... Ishii H.	2003	ITGAL
24	Analysis of major histocompatibility complex and CTLA-4 alleles in Brazilian patients with primary biliary cirrhosis. (12911663)	Bittencourt P.L.... Goldberg A.C.	2003	TNF, CTLA4, HLA-DQB1
25	A patient with Takayasu's arteritis treated with corticosteroids who developed primary biliary cirrhosis. (12793718)	Ito S.... Gejyo F.	2003	CD40LG
26	Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases. (12473246)	Fida S.... Mackay I.R.	2002	SOX13
27	Clinical and biochemical features and therapy responses in primary biliary cirrhosis and primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. (12239904)	GA1nsar F.... Batur Y.	2002	GGT1, SLC17A5
28	Detection of serum nitrite and nitrate in primary biliary cirrhosis: possible role of nitric oxide in bile duct injury. (11982702)	Hokari A.... Toda G.	2002	GGT1, CD40LG, GPT
29	Primary biliary cirrhosis: incidence and predictive factors of cirrhosis development in ursodiol-treated patients. (11874998)	Corpechot C.... Poupon R.E.	2002	ALB
30	Treatment of primary biliary cirrhosis. (11595467)	Szalay F.	2001	GGT1, SLPI
31	Autoantibodies of sera from patients with primary biliary cirrhosis recognize the alpha subunit of the decarboxylase component of human branched-chain 2-oxo acid dehydrogenase complex. (11451161)	Mori T.... Kochi H.	2001	PDP1
32	Tumour necrosis factor alpha and cellular proliferation in primary biliary cirrhosis. (10091104)	Floreani A.... Chiaramonte M.	1999	TNF
33	Elevated serum dipeptidyl peptidase IV (CD26, EC 3.4.14.5) activity in patients with primary biliary cirrhosis. (10207821)	Lakatos P.L.... Szalay F.	1999	DPP4
34	Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis. (9802945)	Malmborg A.C.... Van de Water J.	1998	DLAT
35	Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis. (9566826)	Thomson R.K.... Stevenson F.K.	1998	DLAT
36	Increased CD1d expression on small bile duct epitheli um and epithelioid granuloma in livers in primary biliary cirrhosis. (9731549)	Tsuneyama K.... Nakanuma Y.	1998	MR1
37	Multiple nuclear dot antinuclear antibody in patients without primary biliary cirrhosis. (9699418)	Kurien B.T.... Scofield R.H.	1998	COIL
38	Expression and therapeutic response related to apolip oprotein E polymorphism in primary biliary cirrhosis. (9252087)	Vuoristo M.... Miettinen T.A.	1997	APOE
39	Analysis of T-cell receptor beta of the T-cell clones reactive to the human PDC-E2 163-176 peptide in the context of HLA-DR53 in patients with primary biliary cirrhosis. (9303504)	Ichiki Y.... Niho Y.	1997	DLAT
40	Hemolytic anemia as cause of a marked bilirubin increase in primary biliary cirrhosis (8925755)	Mahl M.A.... Breuer N.	1996	HP
41	Aminoterminal propeptide of type III procollagen and hyaluronan in patients with primary biliary cirrhosis: markers of fibrosis in primary biliary cirrhosis. (8985819)	Remmel T.... Salupere V.	1996	ALB
42	The development of serum alkaline phosphatase and gamma-glutamyl transpeptidase in early stages of primary biliary cirrhosis (7723166)	Ohhira M.... Namiki M.	1995	GGT1, ALPP
43	Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary biliary cirrhosis. (7590661)	Tsuneyama K.... Gershwin M.E.	1995	DLAT
44	Significance of subtype pattern of antimitochondrial antibodies in primary biliary cirrhosis for prognostic parameters and response to ursodeoxycholic acid (7740290)	Wirth H.P.... Ammann R.	1995	F2, ALB, CD40LG
45	Isotypic distribution of anti-pyruvate dehydrogenase antibodies in patients with primary biliary cirrhosis and their family members. (7814462)	Maran R.... Youinou P.	1994	PDP1
46	Dipeptidyl-peptidase IV of human lymphocytes in patients with primary biliary cirrhosis and UDCA therapy (7483686)	KA1rktschiev D.... Schentke K.U.	1993	DPP4
47	Ursodeoxycholic acid for symptomatic primary biliary cirrhosis. Preliminary analysis of a double-blind multicenter trial. Italian Mu lticenter Group for the Study of UDCA in PBC. (8315262)	Battezzati P.M.... Manenti F.	1993	SLC17A5
48	DNA polymorphism of HLA class II genes in primary biliary cirrhosis. (1735557)	Morling N.... Svejgaard A.	1992	CIITA
49	A controlled trial of prednisolone treatment in primary biliary cirrhosis. Three-year results. (1447500)	Mitchison H.C.... James O.F.	1992	ALB
50	Elevated level of serum Mn-superoxide dismutase in patients with primary biliary cirrhosis: possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis. (1682406)	Ono M.... Taniguchi N.	1991	SOD2, CD40LG, CP

Genes related to primary biliary cirrhosis according to GeneCards:

(show top 50)    (show all 259)

id	Symbol	Description	Score	GeneCards Section Context
1	DLAT	dihydrolipoamide S-acetyltransferase	11.1	Summaries, Aliases & Descriptions, Publications
2	PDHX	pyruvate dehydrogenase complex, component X	11.1	Publications, Summaries
3	CENPC1P1	centromere protein C 1 pseudogene 1	11.0	Publications
4	SLC4A2	solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)	11.0	Publications
5	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	11.0	Publications
6	ARL14	ADP-ribosylation factor-like 14	11.0	Publications
7	SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	11.0	Publications
8	PDP1	pyruvate dehyrogenase phosphatase catalytic subunit 1	11.0	Publications
9	GNLY	granulysin	11.0	Publications
10	ORMDL3	ORM1-like 3 (S. cerevisiae)	11.0	Publications
11	ZPBP2	zona pellucida binding protein 2	11.0	Publications
12	CENPB	centromere protein B, 80kDa	11.0	Publications
13	CCL27	chemokine (C-C motif) ligand 27	11.0	Publications
14	SUN2	Sad1 and UNC84 domain containing 2	11.0	Publications
15	TIMMDC1	translocase of inner mitochondrial membrane domain containing 1	11.0	Publications
16	SUOX	sulfite oxidase	11.0	Publications
17	FAM215A	family with sequence similarity 215, member A (non-protein coding)	11.0	Publications
18	CD180	CD180 molecule	11.0	Publications
19	PDHB	pyruvate dehydrogenase (lipoamide) beta	11.0	Publications
20	NAB1	NGFI-A binding protein 1 (EGR1 binding protein 1)	11.0	Publications
21	GSDMB	gasdermin B	11.0	Publications
22	SP100	SP100 nuclear antigen	11.0	Publications
23	NUP210	nucleoporin 210kDa	11.0	UniProt Related, Publications
24	PNKD	paroxysmal nonkinesigenic dyskinesia	11.0	Publications
25	IRF5	interferon regulatory factor 5	11.0	Publications
26	DFFA	DNA fragmentation factor, 45kDa, alpha polypeptide	11.0	Publications
27	REG1A	regenerating islet-derived 1 alpha	11.0	Publications
28	SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	11.0	Publications
29	SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	11.0	Publications
30	DLST	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	11.0	Publications
31	GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	11.0	Publications
32	SEPSECS	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	11.0	Publications
33	SP140	SP140 nuclear body protein	11.0	Publications, UniProt Related
34	COIL	coilin	11.0	Publications
35	SOX13	SRY (sex determining region Y)-box 13	11.0	Publications
36	GGT1	gamma-glutamyltransferase 1	11.0	Publications
37	FCRL3	Fc receptor-like 3	11.0	Publications
38	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
39	ENOPH1	enolase-phosphatase 1	11.0	Publications
40	EDN2	endothelin 2	11.0	Publications
41	CCL8	chemokine (C-C motif) ligand 8	11.0	Publications
42	TNPO3	transportin 3	11.0	Publications
43	TNFSF9	tumor necrosis factor (ligand) superfamily, member 9	11.0	Publications
44	TNFRSF17	tumor necrosis factor receptor superfamily, member 17	11.0	Publications
45	ATOX1	ATX1 antioxidant protein 1 homolog (yeast)	11.0	Publications
46	APEH	N-acylaminoacyl-peptide hydrolase	11.0	Publications
47	KRT7	keratin 7	11.0	Publications
48	IMMT	inner membrane protein, mitochondrial	11.0	Publications
49	MGST1	microsomal glutathione S-transferase 1	11.0	Publications
50	MR1	major histocompatibility complex, class I-related	11.0	Publications

Pathways related to primary biliary cirrhosis according to GeneDecks:

(show top 50)    (show all 127)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	11.1	SELL, CD86, CD4, CD80, ITGA4, ITGAL
2	Immune System38	10.9	PDCD1, CIITA, CD79A, IRF5, IL5, IL6R
3	Antigen processing and presentation20	10.7	CIITA, CD4, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1
4	Bile secretion20	10.7	SCARB1, CA2, CYP3A4, NR1H4, ABCB1, ABCB11
5	Graft-versus-host disease20	10.6	CD86, CD80, IL2, HLA-A, HLA-B, HLA-DPB1
6	Phagosome20	10.5	SCARB1, LAMP1, MPO, CD36, CD14, ITGAV
7	RAR-Gamma-RXR-Alpha Degradation36	10.4	CD80, IL12A, IL2, CCL8, CCL27, TNFSF9
8	IL-6 Pathway36	10.3	BMP6, CD80, IL10, IL12A, IL5, IL6R
9	Autoimmune thyroid disease20	10.2	CD86, CD40LG, CD80, GZMB, IL10, IL2
10	Toll-like receptor signaling pathway20	10.2	CD86, CD14, CD80, IRF5, IL12A, IL1B
11	Allograft rejection20	10.2	CD86, CD40LG, CD80, GZMB, IL10, IL12A
12	Viral myocarditis20	10.1	CD86, CD40LG, CD80, ITGAL, ICAM1, CAV1
13	THC Differentiation Pathway36	10.1	CD86, IL10, IL12A, IL12RB1, IL12RB2, IL2
14	Intestinal immune network for IgA production20	10.1	CD86, CD40LG, CD80, ITGA4, IL10, IL2
15	Th1 Differentiation37	10.0	CD86, CD4, CD80, IL10, IL12A, IL12RB1
16	PGC1Alpha Pathway36	9.9	BMP6, BCL2, CD4, CD80, IL12A, IL1B
17	Akt Signaling36	9.9	CD4, CD80, ITGAL, IL10, IL12RB1, IL2
18	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.9	VDR, BGLAP, IL1B, IL6, APOE, IGF1
19	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.9	VDR, BGLAP, IL1B, IL6, APOE, IGF1
20	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics34	9.8	VDR, MPO, GSTP1, GSTT1, CYP3A4, CYP3A5
21	Influenza A20	9.8	CIITA, IL12A, IL1B, IL6, IFNA1, IFNA2
22	Type I diabetes mellitus20	9.8	CD86, CD80, GZMB, INS, IL12A, IL1B
23	Immune response IL-22 signaling pathway10	9.8	BCL2, CD86, CD4, IL12A, IL12RB1, IL12RB2
24	Immune response_IL-22 signaling pathway41	9.8	BCL2, CD86, CD4, IL12A, IL12RB1, IL12RB2
25	Rheumatoid arthritis20	9.6	CD86, CD80, ITGAL, IL17A, IL1B, IL6
26	Endothelin-1 Signaling Pathway36	9.6	BMP6, CD80, IL10, IL12A, IL1B, IL2
27	Th17 Differentiation37	9.5	CD86, CD4, CD80, IL12RB1, IL17A, IL1B
28	Leishmaniasis20	9.5	ITGA4, IL10, IL12A, IL1B, IFNG, HLA-DPB1
29	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.4	GZMB, IL17A, IL1B, IL23R, IL6, IL6R
30	PEDF Induced Signaling36	9.2	BMP6, BCL2, CD80, IL10, IL12A, IL1B
31	Malaria20	9.2	CD36, CD40LG, ITGAL, IL10, IL12A, IL1B
32	MIF Regulation of Innate Immune Cells36	9.2	BMP6, BCL2, CD14, CD80, IL10, IL12A
33	all-trans-Retinoic Acid Signaling in Brain36	9.2	BMP6, BCL2, CD80, IL10, IL12A, IL1B
34	Molecular Mechanisms of Cancer36	9.1	BMP6, BCL2, ATM, CDKN1A, CD4, CD80
35	Selected targets of GCR-alpha10	9.1	LEP, CDKN1A, INS, IL1B, IL5, IL6
36	MIF Mediated Glucocorticoid Regulation36	9.0	BMP6, BCL2, CD14, CD80, IL10, IL12A
37	Toxoplasmosis20	9.0	BCL2, CIITA, CD40LG, IL10, IL12A, CCR5
38	STAT3 Pathway36	8.9	BMP6, BCL2, CDKN1A, CD4, CD80, IL10
39	Cytokine-cytokine receptor interaction20	8.9	LEP, CD27, CD40LG, IL10, IL12A, IL12RB1
40	Tuberculosis20	8.8	VDR, BCL2, CIITA, LAMP1, CD14, IL10
41	Rho Family GTPases36	8.7	RDX, BMP6, BCL2, CD80, ITGA4, ITGAL
42	ERK Signaling36	8.5	BMP6, CD80, ITGA4, ITGAL, ITGAV, FN1
43	TGF-Beta Pathway36	8.5	BMP6, BCL2, CD4, CD80, IL10, IL12A
44	Antioxidant Action of Vitamin-C36	8.4	BMP6, BCL2, CD4, CD80, IL10, IL12A
45	Glucocorticoid Receptor Signaling36	8.4	BMP6, BCL2, CDKN1A, CD4, CD80, IL10
46	MAPK Family Pathway36	8.3	BMP6, BCL2, CD4, CD80, IL10, IL12A
47	p38 Signaling36	8.2	BMP6, BCL2, CD4, CD80, IL10, IL12A
48	Chagas disease (American trypanosomiasis)20	8.0	IL10, IL12A, IL1B, IL2, IL6, IFNG
49	Tec Kinases Signaling36	8.0	BMP6, BCL2, CD4, CD80, ITGA4, ITGAL
50	JAK-STAT Pathway36	7.5	BMP6, BCL2, CD4, CD80, IL10, IL12A

Compounds related to primary biliary cirrhosis according to GeneDecks:

(show top 50)    (show all 547)

id	Compound	Score	Top Affiliating Genes
1	phosphorus32	11.0	VDR, B2M, GPT, ALPP, CALCA, TNFSF11
2	glucose32	10.8	MKI67, GZMB, ENO1, IFNA2, CALR, TJP1
3	calcium32 9 18 9	13.7	PIK3C2A, REG1A, RETN, CNR1, RDX, VCP
4	allergens32	10.6	PDCD1, CIITA, CETP, CD79A, CD86, CD14
5	phenytoin32 34 9 9	13.3	CNR1, BMP6, CD79A, CD40LG, ALB, ALPP
6	fatty acid32	10.3	PIK3C2A, RETN, SCARB1, LEP, UCP2, MKI67
7	rifampicin32	10.2	GPT, HP, CYP3A4, CYP2E1, CYP2D6, CYP3A5
8	bezafibrate32 9 9	12.2	PIK3C2A, UCP2, CETP, INS, APOA2, APOB
9	oxygen32 18	11.0	PIK3C2A, BCL2, SCARB1, CIITA, ATOX1, ATM
10	pge232	9.9	CIITA, CD86, CD14, CD4, FOXP3, FN1
11	heparin32 9 18 9	12.9	PIK3C2A, BGLAP, LBR, CETP, MPO, CD79A
12	pmma32	9.9	BMP6, B2M, CD40LG, FN1, ALPP, CALCA
13	fibrinogen32	9.9	PIK3C2A, RETN, LEP, CD79A, CD14, CD40LG
14	ascorbic acid32 18	10.8	PCNA, VDR, BGLAP, CD36, CD40LG, GSTM1
15	calcitriol32 42 9 18 9	13.7	VDR, BMP6, BGLAP, B2M, CDKN1A, CD36
16	valine32	9.7	UCP2, B2M, CETP, MPO, GSTM1, GSTP1
17	nash32	9.6	RETN, LEP, UCP2, INS, GPT, TNF
18	glutamate32	9.5	CNR1, CNR2, PCNA, VDR, BMP6, LEP
19	dextran sulfate32	9.5	SELL, CIITA, CETP, MPO, CD36, CD4
20	ccl332	9.4	IL10, IL1B, IL6, CCL8, CCL27, CCR5
21	fenofibrate32 9 9	11.3	PIK3C2A, RETN, SCARB1, LEP, UCP2, CETP
22	norepinephrine32 9 18 9	12.3	PIK3C2A, RETN, CNR1, SELL, BMP6, LEP
23	biotin32 9 18 9	12.3	PCNA, SELL, MUC1, B2M, CD79A, CD40LG
24	betacarotene32	9.3	PCNA, VDR, SCARB1, LEP, CETP, CD79A
25	lipid32	9.3	PIK3C2A, RETN, CNR1, CNR2, RDX, VCP
26	arginine32	9.2	PIK3C2A, CNR1, CNR2, VDR, BGLAP, LEP
27	ribonucleic acid32	9.1	BMP6, SCARB1, CIITA, MUC1, UCP2, GZMB
28	aspirin32 34 18	11.1	CNR1, PCNA, SELL, VDR, BMP6, SCARB1
29	imatinib32 34 9 9	12.0	SELL, BMP6, BCL2, CEACAM1, CDKN1A, FN1
30	chloroquine32 34 9 9	11.9	BMP6, CIITA, B2M, CD79A, CD4, ITGAL
31	etanercept32 9 9	10.9	LEP, IL10, IL17A, IL1B, IL1RN, IL2RB
32	rantes32	8.9	SELL, BMP6, CIITA, LBR, CD14, CD4
33	acetylcholine32 9 18 9	11.7	PIK3C2A, CNR1, BMP6, LEP, LBR, MPO
34	folate32	8.6	VDR, MUC1, SARDH, B2M, CD79A, CD40LG
35	thalidomide32 42 9 9	11.4	SELL, B2M, CD36, CD40LG, IL10, IL1B
36	wortmannin32 42	9.3	PIK3C2A, BCL2, LEP, ATM, CDKN1A, CD86
37	il 1032	8.3	VDR, BMP6, IL10, IL1B, IL1RN, IL2
38	prednisolone32 9 9	10.2	PIK3C2A, SELL, BMP6, BGLAP, MPO, CD79A
39	estrogen32	8.1	RETN, RDX, PCNA, VDR, BMI1, BGLAP
40	butyrate32	8.0	PCNA, VDR, BMP6, BCL2, LEP, MUC1
41	pdtc32	7.9	BCL2, CDKN1A, IL6, IFNG, ICAM1, F3
42	doxorubicin32 34 9 9	10.8	PIK3C2A, BMP6, B2M, ATM, CD40LG, ITGAL
43	retinoid32	7.8	SELL, VDR, BMP6, BCL2, CDKN1A, CD14
44	curcumin32	7.3	BCL2, CDKN1A, GSTP1, IL17A, IL1B, IL6
45	cisplatin32 34 9 9	10.1	PIK3C2A, CNR2, PCNA, BMP6, BGLAP, BCL2
46	paclitaxel32 34 9 9	10.1	PCNA, BMP6, BCL2, CDKN1A, FN1, MKI67
47	cyclosporin a32 42	8.1	PIK3C2A, SEPSECS, VDR, BGLAP, LEP, CIITA
48	retinoic acid32 42 18	9.0	SELL, VDR, BMP6, BGLAP, UCP2, LBR
49	genistein32 9 18 9	8.6	REG1A, PCNA, SELL, VDR, BCL2, LBR
50	dexamethasone32 42 34 9 9	9.5	RETN, PCNA, SELL, VDR, BMP6, BGLAP

Cellular components related to primary biliary cirrhosis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial matrix	GO:005759	11.1	PDHB, PDHX, PDP1, DBT, OGDH, SOD2
2	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.7	HLA-E, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
3	ER to Golgi transport vesicle membrane	GO:012507	10.6	HLA-E, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
4	endosome membrane	GO:010008	10.4	RPS27A, TLR3, TLR4, TLR9, TAB1, SUN2
5	external side of plasma membrane	GO:009897	10.4	CXCR3, IL12RB1, ITGAV, ITGAL, ITGA4, CD40LG
6	endocytic vesicle membrane	GO:030666	10.3	NOS3, HLA-DRB4, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1
7	integral to plasma membrane	GO:005887	10.2	CD40LG, CD36, CD27, CEACAM1, LAMP1, MUC1
8	membrane	GO:016020	9.5	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, ABCC4
9	cell surface	GO:009986	9.2	TNFRSF1A, DMD, CYP3A4, NOD2, ABCB1, TLR2
10	plasma membrane	GO:005886	9.1	TLR4, TNFRSF1A, TNFRSF17, TNF, HLA-E, HLA-DRB4
11	extracellular region	GO:005576	8.2	GAST, HGF, ZPBP2, SIGLEC1, CP, SLPI
12	extracellular space	GO:005615	7.4	LTA, COL1A1, SPP1, TNFSF9, TNFSF11, TNFSF10

Biological processes related to primary biliary cirrhosis according to GeneDecks:

(show top 50)    (show all 57)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of acetyl-CoA biosynthetic process from pyruvate	GO:010510	11.2	PDP1, PDHX, PDHB, PDHA1, DLD, DLAT
2	T cell costimulation	GO:031295	11.1	HLA-DQB1, HLA-DRB1, HLA-DRB4, TNFRSF13C, CTLA4, DPP4
3	small molecule metabolic process	GO:044281	11.0	ABCB1, PDP1, PDHX, PDHB, PDHA1, NOS3
4	interferon-gamma-mediated signaling pathway	GO:060333	10.9	HLA-DQB1, HLA-DRB1, HLA-DRB4, HLA-E, SP100, PML
5	bile acid metabolic process	GO:008206	10.7	SLCO1B1, SLC10A1, SLCO1B3, ABCC3, ABCB11, NR1H4
6	detection of bacterium	GO:016045	10.7	CD1D, HLA-A, HLA-B, HLA-DRB1, HLA-DRB4, NOD2
7	positive regulation of interleukin-12 production	GO:032735	10.7	TLR2, TLR3, TLR4, TLR9, HSPD1, IDO1
8	response to lipopolysaccharide	GO:032496	10.6	NR1H4, LTA, EDN1, ACP5, TLR4, THBD
9	bile acid and bile salt transport	GO:015721	10.6	ALB, ABCB11, ABCC3, SLCO1B3, SLC10A1, SLCO1B1
10	positive regulation of interleukin-8 production	GO:032757	10.6	TLR9, TLR5, TLR4, TLR3, TLR2, CALCA
11	positive regulation of tumor necrosis factor production	GO:032760	10.5	TLR9, TLR4, TLR3, TLR2, NOD2, TNFRSF1A
12	positive regulation of osteoclast differentiation	GO:045672	10.5	IL17A, IL23R, IFNG, CA2, TNF, TNFSF11
13	defense response to Gram-positive bacterium	GO:050830	10.5	TLR2, ACP5, LTA, TNF, MBL2, IL6R
14	positive regulation of interferon-gamma production	GO:032729	10.5	TLR4, LTA, TNF, HSPD1, IL23R, IL2
15	immune response	GO:006955	10.5	CNR2, CCL8, CCL27, CCR5, IGHM, ICOS
16	positive regulation of chemokine production	GO:032722	10.4	TLR9, IL6, IL6R, TNF, TLR2, TLR3
17	cell surface receptor signaling pathway	GO:007166	10.4	F2, TNFRSF13B, EDN1, EDN2, EDN3, CXCL10
18	negative regulation of interleukin-6 production	GO:032715	10.4	TLR4, TLR9, TNFRSF1A, TNF, ARRB1, IL10
19	positive regulation of T cell proliferation	GO:042102	10.3	TNFRSF13C, IFNG, IL6, IL23R, IL1B, IL12A
20	negative regulation of growth of symbiont in host	GO:044130	10.3	IL10, MBL2, IFNG, TNF, LTA, TLR2
21	cytokine-mediated signaling pathway	GO:019221	10.3	HLA-B, STAT4, NUP210, NUP62, PML, STAT3
22	response to cytokine stimulus	GO:034097	10.3	PML, TIMP1, ACP5, NOS3, SP100, SRF
23	leukocyte migration	GO:050900	10.3	THBD, COL1A1, CAV1, F2, ICAM1, APOB
24	positive regulation of NF-kappaB import into nucleus	GO:042346	10.3	TLR4, TLR9, TLR3, TLR2, IL1B, TNF
25	positive regulation of interleukin-6 production	GO:032755	10.3	TLR9, TLR4, TLR3, TLR2, NOD2, TNF
26	positive regulation of MHC class II biosynthetic process	GO:045348	10.2	TLR4, IFNG, IL10, CD40LG, CIITA
27	response to glucocorticoid stimulus	GO:051384	10.1	ABCB4, TNF, CAV1, GOT1, APOA2, IL6
28	defense response to Gram-negative bacterium	GO:050829	10.0	CD4, IL23R, IL6, IL6R, NOS2, TLR4
29	acute-phase response	GO:006953	9.8	STAT3, F2, MBL2, IL6R, IL6, IL1RN
30	virus-host interaction	GO:019048	9.8	TNFRSF1A, SP1, SP100, KRT7, KRT19, EIF2AK2
31	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.8	NUP62, TLR9, TLR4, TLR3, RPS27A, NOD2
32	platelet activation	GO:030168	9.7	SRF, COL1A1, ABCC4, TIMP1, TGFB1, HGF
33	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.7	IL6R, IGF1, TLR4, HGF, IL6, IL5
34	cellular response to lipopolysaccharide	GO:071222	9.6	TLR4, NOS2, ICAM1, IFNG, CCR5, IL10
35	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	TGFB1, TLR4, TLR2, NOS3, TNF, IL1B
36	response to estrogen stimulus	GO:043627	9.5	KRT19, PPARG, TNFRSF11B, GHRL, ESR1, CAV1
37	inflammatory response	GO:006954	9.5	CNR2, BMP6, CD14, CD40LG, CD180, ITGAL
38	cell-cell signaling	GO:007267	9.4	CALCA, TNFSF10, TNFSF9, LTA, EDN1, EDN3
39	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.3	PPARG, SP100, SRF, DDR2, TNFSF11, TNF
40	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.2	NFKB1, TLR2, TLR3, TLR4, TLR9, TGFB1
41	blood coagulation	GO:007596	9.2	F2, ALB, CAV1, NOS2, NOS3, COL1A1
42	signal transduction	GO:007165	9.0	NR3C1, NR1I2, NR1H4, PPARG, DDR2, DLG5
43	positive regulation of nitric oxide biosynthetic process	GO:045429	9.0	TLR4, TLR2, EDN1, TNF, ESR1, ICAM1
44	positive regulation of cell proliferation	GO:008284	9.0	EDN1, EDN2, EDN3, TIMP1, TGFB1, TGFBR2
45	negative regulation of apoptotic process	GO:043066	8.8	HSPD1, GHRL, TNF, TIMP1, DFFA, NUP62
46	response to hypoxia	GO:001666	8.7	NOS3, LTA, EDN1, TLR4, TGFB1, DPP4
47	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.7	PTCH1, SP100, PPARG, NR1H4, RPS27A, NFKB1
48	anti-apoptosis	GO:006916	8.2	IGF1, F3, GHRL, TNF, NR3C1, NOS3
49	response to drug	GO:042493	8.2	EDN1, LTA, NOS3, PPARG, ABCB1, ABCB4
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.6	RPS27A, RPS6KA4, NR1H4, PPARG, SP1, SRF

Molecular functions related to primary biliary cirrhosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	8.7	TNF, TNFRSF11B, TNFSF10, TNFSF11, TNFSF9, SPP1
2	growth factor activity	GO:008083	8.5	IL5, IL6, IGF1, F2, TGFB1, IL2
3	protein binding	GO:005515	5.2	HLA-A, CTLA4, PPARG, NR1H4, NR1I2, NR3C1