MCID: PRM006
MIFTS: 51

Primary Biliary Cirrhosis malady

Categories: Gastrointestinal diseases, Immune diseases, Liver diseases

Aliases & Classifications for Primary Biliary Cirrhosis

Aliases & Descriptions for Primary Biliary Cirrhosis:

Name: Primary Biliary Cirrhosis 38 12 14 69
Chronic Nonsuppurative Destructive Cholangitis 12
Biliary Cirrhosis Primary 52
Liver Cirrhosis, Biliary 42
Biliary Liver Cirrhosis 12
Cholestatic Cirrhosis 12
Biliary Cirrhosis 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12236
ICD10 33 K74.3 K74.5
ICD9CM 35 571.6
MeSH 42 D008105

Summaries for Primary Biliary Cirrhosis

Disease Ontology : 12 A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.

MalaCards based summary : Primary Biliary Cirrhosis, also known as chronic nonsuppurative destructive cholangitis, is related to cutaneous polyarteritis nodosa and artery disease. An important gene associated with Primary Biliary Cirrhosis is DLAT (Dihydrolipoamide S-Acetyltransferase), and among its related pathways/superpathways are Bile secretion and Glyoxylate metabolism and glycine degradation. The drugs Ursodeoxycholic acid and Meloxicam have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, liver and t cells, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Primary Biliary Cirrhosis

Diseases in the Primary Biliary Cirrhosis family:

Biliary Cirrhosis, Primary, 3 Biliary Cirrhosis, Primary, 1
Biliary Cirrhosis, Primary, 2 Biliary Cirrhosis, Primary, 4
Biliary Cirrhosis, Primary, 5

Diseases related to Primary Biliary Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
id Related Disease Score Top Affiliating Genes
1 cutaneous polyarteritis nodosa 29.8 CD40LG CD79A
2 artery disease 29.6 CD40LG CD79A F2
3 b-cell lymphomas 29.1 CD40LG CTLA4 DLAT F2 GGT1 SEPSECS
4 reynolds syndrome 12.2
5 primary biliary cholangitis 12.1
6 biliary cirrhosis, primary, 1 11.2
7 biliary cirrhosis, primary, 2 11.1
8 biliary cirrhosis, primary, 4 11.1
9 biliary cirrhosis, primary, 5 11.1
10 biliary cirrhosis, primary, 3 11.1
11 hepatitis 10.7
12 autoimmune hepatitis 10.6
13 cholangitis 10.5
14 sclerosing cholangitis 10.4
15 bile duct adenocarcinoma 10.3 ALB CD40LG
16 hepatocellular carcinoma 10.3
17 nondystrophic myotonia 10.2 ALB F2
18 alcoholic neuropathy 10.2 CD40LG CD79A
19 camptodactyly vertebral fusion 10.2 CD40LG CD79A
20 liver disease 10.2
21 spinal polio 10.2 CD40LG CD79A
22 rabies 10.2 CD40LG CD79A
23 unilateral retinoblastoma 10.2 CD40LG CD79A
24 mesangial proliferative glomerulonephritis 10.2 CD40LG CD79A
25 estrogen excess 10.2 ALB CD40LG
26 delta chain disease 10.2 CD40LG CD79A
27 discitis 10.2 CD40LG CD79A
28 atopic dermatitis 6 10.2 ALB CD79A
29 spinal canal and spinal cord meningioma 10.2 CD40LG CD79A
30 trichostrongyloidiasis 10.2 CD40LG CD79A
31 heart septal defect 10.2 CD40LG CD79A
32 cholestasis, intrahepatic, of pregnancy, 1 10.2 ABCB4 GGT1 NR1H4
33 arthritis 10.2
34 mild pre-eclampsia 10.2 CD40LG CD79A
35 bile duct cystadenocarcinoma 10.2 ALB F2 GGT1
36 primary lacrimal atrophy 10.2 CD40LG CD79A CTLA4
37 retinal microaneurysm 10.2 CD40LG CD79A
38 renal tubular acidosis 10.2
39 freiberg's disease 10.2 ALB CD40LG F2
40 chronic inflammatory demyelinating polyneuritis 10.1 ALB CD40LG F2
41 schneiderian carcinoma 10.1 ALB CD79A
42 hereditary alpha tryptasemia syndrome 10.1 ALB CD40LG F2
43 benign deep fibrous histiocytoma 10.1 ALB CD40LG F2
44 rheumatoid arthritis 10.1
45 hemolytic anemia 10.1
46 mixed malaria 10.1 CD40LG CD79A GGT1
47 hypertrophic elongation of cervix 10.1 CD40LG CD79A GGT1
48 pediatric meningioma 10.1 CD40LG CD79A
49 depressed scar 10.1 ALB CD40LG F2
50 tonsil cancer 10.1 CD40LG CD79A

Comorbidity relations with Primary Biliary Cirrhosis via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Cholangitis Deficiency Anemia
Hepatic Encephalopathy Hypothyroidism
Portal Hypertension

Graphical network of the top 20 diseases related to Primary Biliary Cirrhosis:



Diseases related to Primary Biliary Cirrhosis

Symptoms & Phenotypes for Primary Biliary Cirrhosis

MGI Mouse Phenotypes related to Primary Biliary Cirrhosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 SLC4A2 ABCB4 ALB CTLA4 F2 LBR
2 endocrine/exocrine gland MP:0005379 9.28 ABCB4 ALB CD40LG CENPB CTLA4 GGT1

Drugs & Therapeutics for Primary Biliary Cirrhosis

Drugs for Primary Biliary Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 244)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128-13-2 31401
2
Meloxicam Approved, Vet_approved Phase 4 71125-38-7 5281106 54677470
3
Lactulose Approved Phase 4 4618-18-2 11333
4
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173
5
Abatacept Approved Phase 4 332348-12-6 10237
6
Methylene blue Investigational Phase 4 61-73-4
7 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
8 Cholagogues and Choleretics Phase 4,Phase 3,Phase 2,Phase 1
9 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Anti-Bacterial Agents Phase 4,Phase 1
12 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
13 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
14 Antibiotics, Antitubercular Phase 4
15 Analgesics Phase 4,Phase 3
16 Analgesics, Non-Narcotic Phase 4
17 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1
18 Anti-Inflammatory Agents, Non-Steroidal Phase 4
19 Cyclooxygenase 2 Inhibitors Phase 4
20 Cyclooxygenase Inhibitors Phase 4
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1
22 rifamycin SV Phase 4
23 Rifamycins Phase 4
24 Immunosuppressive Agents Phase 4,Phase 3
25 methionine Nutraceutical Phase 4,Phase 2
26
Colchicine Approved Phase 3 64-86-8 6167 2833
27
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
28
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
29
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
30
Tauroursodeoxycholic acid Approved, Investigational Phase 3 14605-22-2 12443252
31
Copper Approved Phase 3 15158-11-9, 7440-50-8 27099
32
Bezafibrate Approved Phase 3 41859-67-0 39042
33
Lenograstim Approved Phase 3 135968-09-1
34
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
35
chenodeoxycholic acid Approved Phase 3,Phase 2 474-25-9 10133
36
Fenofibrate Approved Phase 3,Phase 2,Phase 1 49562-28-9 3339
37
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
38
Budesonide Approved Phase 3,Phase 1 51333-22-3 63006 5281004
39
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
41
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
42
Tetrathiomolybdate Investigational Phase 3 16330-92-0
43 Antimetabolites Phase 3,Phase 2,Phase 1
44 Hypolipidemic Agents Phase 3,Phase 2,Phase 1
45 Lipid Regulating Agents Phase 3,Phase 2,Phase 1
46 Antimetabolites, Antineoplastic Phase 3
47 Antimitotic Agents Phase 3
48 Dermatologic Agents Phase 3,Phase 2
49 Folic Acid Antagonists Phase 3
50 Vitamin B Complex Phase 3

Interventional clinical trials:

(show top 50) (show all 169)
id Name Status NCT ID Phase
1 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
2 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4
3 Clinical Study About the Role of COX-2 Inhibitor in Liver Cirrhosis With Biliary Atresia Completed NCT02298218 Phase 4
4 The Safety/Efficacy Of Rifaximin With/Without Lactulose In Subjects With A History Of Recurrent Hepatic Encephalopathy Completed NCT01842581 Phase 4
5 Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue Recruiting NCT03120637 Phase 4
6 Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis Active, not recruiting NCT02078882 Phase 4
7 The INFECIR-2 Albumin Prevention Study Terminated NCT02034279 Phase 4
8 Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis Completed NCT00004748 Phase 3
9 Study of Combivir for Patients With Primary Biliary Cirrhosis Completed NCT00490620 Phase 2, Phase 3
10 Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis Completed NCT01857284 Phase 3
11 Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary Cirrhosis Completed NCT00805805 Phase 3
12 Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis Completed NCT00004784 Phase 3
13 Ursodiol-Methotrexate for Primary Biliary Cirrhosis Completed NCT00006168 Phase 3
14 Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis Completed NCT00844402 Phase 3
15 Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Completed NCT01654731 Phase 3
16 Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC Completed NCT01829698 Phase 3
17 Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure Completed NCT01383460 Phase 3
18 Trial of High-dose Urso in Primary Sclerosing Cholangitis Completed NCT00059202 Phase 2, Phase 3
19 Gabapentin to Treat Itch in Patients With Liver Disease Completed NCT00058890 Phase 3
20 Phase 3 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cirrhosis Recruiting NCT02308111 Phase 3
21 Use of Bezafibrate in Patients With Primary Biliary Cirrhosis to Archive Complete Biochemical Response in Non-responders Recruiting NCT02937012 Phase 3
22 Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Recruiting NCT02823353 Phase 3
23 Fuzhenghuayu in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Recruiting NCT02916290 Phase 3
24 Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid Recruiting NCT02823366 Phase 3
25 Fuzhenghuayu for Patients With PBC Who Had An Inadequate Response to Ursodeoxycholic Acid Recruiting NCT02916641 Phase 3
26 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy Recruiting NCT02721862 Phase 3
27 Effectiveness of the Use of the New Hemostatic Patch Hemopatch ® in Patients Undergoing Surgical Liver Resection Recruiting NCT02769754 Phase 3
28 The Effect of Bezafibrate on Cholestatic Itch Recruiting NCT02701166 Phase 3
29 Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis Active, not recruiting NCT01473524 Phase 3
30 Metformin in Intrahepatic Cholestasis of Pregnancy Not yet recruiting NCT03056274 Phase 2, Phase 3
31 Ursodeoxycholic Acid Plus Budesonide Versus Ursodeoxycholic Acid Alone in Primary Biliary Cirrhosis (PBC) Terminated NCT00746486 Phase 3
32 Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis Unknown status NCT01662973 Phase 1, Phase 2
33 Study of Rituximab in Patients With Steroid-Refractory Chronic Graft-Versus-Host Disease Unknown status NCT00472225 Phase 2
34 A Clinical Study to Evaluate the Safety and Efficacy of Mesenchymal Stem Cells in Liver Cirrhosis Unknown status NCT01877759 Phase 1, Phase 2
35 Study of INT 747 in Combination With URSO in Patients With Primay Biliary Cirrhosis (PBC) Completed NCT00550862 Phase 2
36 Pentoxifylline for Primary Biliary Cirrhosis Completed NCT01249092 Phase 2
37 Moexipril for Primary Biliary Cirrhosis Completed NCT00588302 Phase 2
38 Initial Study of Rituximab to Treat Primary Biliary Cirrhosis Completed NCT00364819 Phase 1, Phase 2
39 Use of Fenofibrate for Primary Biliary Cirrhosis Completed NCT00575042 Phase 2
40 A Study of Efficacy and Safety of Ustekinumab in Patients With Primary Biliary Cirrhosis (PBC) Who Had an Inadequate Response to Ursodeoxycholic Acid Completed NCT01389973 Phase 2
41 Phase 2b Study of NGM282 Extended Treatment in Patients With Primary Biliary Cirrhosis Completed NCT02135536 Phase 2
42 Phase 2 Study of NGM282 in Patients With Primary Biliary Cirrhosis Completed NCT02026401 Phase 2
43 B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis Completed NCT02376335 Phase 2
44 Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis Completed NCT01904058 Phase 2
45 Phase 2 Study on Effects of Obeticholic Acid (OCA) on Lipoprotein Metabolism in Subjects With Primary Biliary Cirrhosis Completed NCT01865812 Phase 2
46 Study of INT-747 as Monotherapy in Patients With PBC Completed NCT00570765 Phase 2
47 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of Pruritus Completed NCT01899703 Phase 2
48 Treatment of Cholestatic Pruritus With Sertraline Completed NCT00058903 Phase 2
49 A Phase II, Double-blinded, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Vitalliver in Patients With Decompensated Cirrhosis Completed NCT00562783 Phase 2
50 Pilot Study of FFP104 Dose Escalation in PBC Subjects Recruiting NCT02193360 Phase 1, Phase 2

Search NIH Clinical Center for Primary Biliary Cirrhosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Primary Biliary Cirrhosis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: liver cirrhosis, biliary

Genetic Tests for Primary Biliary Cirrhosis

Anatomical Context for Primary Biliary Cirrhosis

MalaCards organs/tissues related to Primary Biliary Cirrhosis:

39
Liver, T Cells, Bone, B Cells, Testes, Thyroid, Monocytes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Primary Biliary Cirrhosis:
id Tissue Anatomical CompartmentCell Relevance
1 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Primary Biliary Cirrhosis

Articles related to Primary Biliary Cirrhosis:

(show top 50) (show all 1196)
id Title Authors Year
1
Clinical relevance of combined anti-mitochondrial M2 detection assays for primary biliary cirrhosis. ( 27864100 )
2017
2
A Systems Model for Ursodeoxycholic Acid Metabolism in Healthy and Patients With Primary Biliary Cirrhosis. ( 27537780 )
2016
3
Autoimmune haemolytic anaemia is a rare association with primary biliary cirrhosis. ( 27269759 )
2016
4
Editorial: improved understanding of the epidemiology of primary biliary cirrhosis in South Korea. ( 26843341 )
2016
5
Overlap of IgG4-related Disease and Primary Biliary Cirrhosis Complicated with Autoimmune Thrombocytopenia. ( 27181554 )
2016
6
A Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety: Modafinil in the Treatment of Fatigue in Patients With Primary Biliary Cirrhosis. ( 27148676 )
2016
7
A case of primary biliary cirrhosis. ( 27728258 )
2016
8
BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial. ( 27431238 )
2016
9
Bullous pemphigoid and primary biliary cirrhosis, an infrequent association: A case report. ( 26949192 )
2016
10
Ganglionic acetylcholine receptor autoantibodies in patients with autoimmune diseases including primary biliary cirrhosis. ( 27538899 )
2016
11
Sclerostin Expression in Bile Ducts of Patients with Chronic Cholestasis May Influence the Bone Disease in Primary Biliary Cirrhosis. ( 27019303 )
2016
12
Chronic spontaneous urticaria associated with primary biliary cirrhosis: a case report and literature review. ( 27879079 )
2016
13
Primary biliary cirrhosis has high wait-list mortality among patients listed for liver transplantation. ( 27754570 )
2016
14
A Case of Frontal Fibrosing Alopecia in a Patient with Primary Biliary Cirrhosis and Polymyalgia Rheumatica. ( 27843932 )
2016
15
The relationship between liver histology and noninvasive markers in primary biliary cirrhosis. ( 27092904 )
2016
16
Liver damage in primary biliary cirrhosis and accompanied by primary SjAPgren's syndrome: a retrospective pilot study. ( 27536204 )
2016
17
Red Blood Cell Distribution Width to Platelet Ratio is Related to Histologic Severity of Primary Biliary Cirrhosis. ( 26986159 )
2016
18
Primary Biliary Cirrhosis and the Microbiome. ( 27997975 )
2016
19
Insight into the natural history of primary biliary cirrhosis: A systemic review of data from placebo-controlled clinical trials. ( 27458850 )
2016
20
Association of IL12A Expression Quantitative Trait Loci (eQTL) With Primary Biliary Cirrhosis in a Chinese Han Population. ( 27175695 )
2016
21
Obeticholic acid for the treatment of primary biliary cirrhosis. ( 27589928 )
2016
22
Cutaneous Metastasis due to Breast Cancer in a Patient with Primary Biliary Cirrhosis: A Case Report. ( 27920708 )
2016
23
Serum proteomic signatures as biomarkers of primary biliary cirrhosis diagnosis and prognosis. ( 27707675 )
2016
24
Primary Biliary Cirrhosis Beyond Ursodeoxycholic Acid. ( 26870929 )
2016
25
Low Incidence of Primary Biliary Cirrhosis (PBC) in First Degree Relatives of PBC Probands after 8 Years of Follow Up. ( 27062298 )
2016
26
Exercise therapy in primary biliary cirrhosis: the importance of moving while sitting on a surgical waiting list-a case study. ( 27429732 )
2016
27
Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis: an Update on MR Imaging Findings with Recent Developments. ( 27981308 )
2016
28
A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. ( 26842849 )
2016
29
A rare nonsynonymous variant in the lipid metabolic gene HELZ2 related to primary biliary cirrhosis in Chinese Han. ( 27047549 )
2016
30
Pulmonary Manifestations among Patients with Primary Biliary Cirrhosis. ( 27777894 )
2016
31
Primary biliary cirrhosis associated with Graves' disease in a male patient. ( 26935935 )
2016
32
Primary rectal mucosa-associated lymphoid tissue lymphoma in a patient with previously identified primary biliary cirrhosis and secondary SjAPgren's syndrome. ( 27037914 )
2016
33
Liver fibrosis progression predicts survival in patients with primary biliary cirrhosis. ( 27189879 )
2016
34
Bile Acids and the Potential Role in Primary Biliary Cirrhosis. ( 27832649 )
2016
35
Quantitative fibrosis parameters highly predict esophageal-gastro varices in primary biliary cirrhosis. ( 27049254 )
2016
36
Interleukin-17A-Induced Epithelial-Mesenchymal Transition of Human Intrahepatic Biliary Epithelial Cells: Implications for Primary Biliary Cirrhosis. ( 27916760 )
2016
37
Subtle presentation of active primary biliary cirrhosis in chronic hepatitis B: a case report. ( 26893441 )
2016
38
Red blood cell distribution width and mean platelet volume are potential prognostic indices for patients with primary biliary cirrhosis. ( 27754960 )
2016
39
Identification of microRNA profiles associated with refractory primary biliary cirrhosis. ( 27511723 )
2016
40
Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis. ( 27246196 )
2016
41
Clinical characteristics of drug-induced liver injury and primary biliary cirrhosis. ( 27672278 )
2016
42
Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis. ( 27243236 )
2016
43
Diagnostic accuracy of two tests for determination of anti-m2 in the diagnosis of primary biliary cirrhosis: Is it possible to predict the course of the disease? ( 27475095 )
2016
44
Primary biliary cirrhosis degree assessment by acoustic radiation force impulse imaging and hepatic fibrosis indicators. ( 27298571 )
2016
45
Clinical Course and Genetic Susceptibility of Primary Biliary Cirrhosis: Analysis of a Prospective Cohort. ( 28070198 )
2016
46
Metabolic Bone Disease in Primary Biliary Cirrhosis. ( 27261902 )
2016
47
A Patient With Primary Biliary Cirrhosis Accompanied by Wilson's Disease. ( 27148382 )
2016
48
Impact of Microbes on the Pathogenesis of Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC). ( 27834858 )
2016
49
Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease. ( 26293907 )
2015
50
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways. ( 26394269 )
2015

Variations for Primary Biliary Cirrhosis

Expression for Primary Biliary Cirrhosis

Search GEO for disease gene expression data for Primary Biliary Cirrhosis.

Pathways for Primary Biliary Cirrhosis

Pathways related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.98 ABCB4 NR1H4 SLC4A2
2
Show member pathways
10.54 DBT DLAT OGDH PDHX

GO Terms for Primary Biliary Cirrhosis

Cellular components related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 CD40LG CD79A CTLA4 F2
2 pyruvate dehydrogenase complex GO:0045254 8.62 DLAT PDHX

Biological processes related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 glyoxylate metabolic process GO:0046487 9.26 DBT DLAT OGDH PDHX
2 regulation of acetyl-CoA biosynthetic process from pyruvate GO:0010510 9.16 DLAT PDHX
3 cellular nitrogen compound metabolic process GO:0034641 8.92 DBT DLAT OGDH PDHX

Molecular functions related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring acyl groups GO:0016746 9.46 DBT DLAT GGT1 PDHX
2 chromo shadow domain binding GO:0070087 8.96 LBR SP100
3 pyruvate dehydrogenase (NAD+) activity GO:0034604 8.62 DLAT PDHX

Sources for Primary Biliary Cirrhosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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