MCID: PRM006
MIFTS: 55

Primary Biliary Cirrhosis

Categories: Gastrointestinal diseases, Liver diseases, Immune diseases

Aliases & Classifications for Primary Biliary Cirrhosis

MalaCards integrated aliases for Primary Biliary Cirrhosis:

Name: Primary Biliary Cirrhosis 37 12 72 36 14 69
Biliary Cirrhosis 69 28
Chronic Nonsuppurative Destructive Cholangitis 12
Biliary Cirrhosis Primary 51
Liver Cirrhosis, Biliary 41
Biliary Liver Cirrhosis 12
Cholestatic Cirrhosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12236
ICD10 32 K74.3 K74.5
ICD9CM 34 571.6
MeSH 41 D008105
KEGG 36 H01467

Summaries for Primary Biliary Cirrhosis

Disease Ontology : 12 A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts.

MalaCards based summary : Primary Biliary Cirrhosis, also known as biliary cirrhosis, is related to autoimmune hepatitis and sclerosing cholangitis. An important gene associated with Primary Biliary Cirrhosis is DLAT (Dihydrolipoamide S-Acetyltransferase), and among its related pathways/superpathways are Bile secretion and Glyoxylate metabolism and glycine degradation. The drugs Ursodeoxycholic acid and chenodeoxycholic acid have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, liver and t cells.

Wikipedia : 72 Primary biliary cholangitis (PBC), also known as primary biliary cirrhosis, is an autoimmune disease of... more...

Related Diseases for Primary Biliary Cirrhosis

Diseases in the Primary Biliary Cirrhosis family:

Biliary Cirrhosis, Primary, 1 Biliary Cirrhosis, Primary, 2
Biliary Cirrhosis, Primary, 3 Biliary Cirrhosis, Primary, 4
Biliary Cirrhosis, Primary, 5

Diseases related to Primary Biliary Cirrhosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 305)
# Related Disease Score Top Affiliating Genes
1 autoimmune hepatitis 31.8 CD40LG DLAT F2 SEPSECS
2 sclerosing cholangitis 31.7 ABCB4 ALB CD40LG
3 cholangitis 31.4 ABCB4 ALB CD40LG DLAT F2 SP100
4 cholangitis, primary sclerosing 31.4 ABCB4 DLAT NUP210 SEPSECS SP100
5 cholestasis 30.9 ABCB4 ALPP F2 NR1H4
6 purpura 30.8 CD40LG CD79A F2
7 liver disease 30.8 ABCB4 ALB ALPP DLAT F2 NR1H4
8 immunoglobulin g deficiency 30.6 CD40LG CD79A
9 antiphospholipid syndrome 30.5 CD40LG CD79A F2
10 primary biliary cholangitis 12.4
11 reynolds syndrome 12.4
12 biliary cirrhosis, primary, 1 12.1
13 biliary cirrhosis, primary, 2 11.5
14 biliary cirrhosis, primary, 3 11.2
15 biliary cirrhosis, primary, 4 11.2
16 biliary cirrhosis, primary, 5 11.2
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.8
18 hepatitis 10.8
19 colorado tick fever 10.8 ALB CD40LG
20 antipyrine metabolism 10.7 ALB F2
21 non-a-e hepatitis 10.7 ALB F2
22 selective igg deficiency disease 10.7 CD40LG CD79A
23 c1q nephropathy 10.7 CD40LG CD79A
24 meningovascular neurosyphilis 10.7 CD40LG CD79A
25 plasmodium malariae malaria 10.7 ALB CD40LG
26 alpha chain disease 10.7 CD40LG CD79A
27 brill-zinsser disease 10.7 CD40LG CD79A
28 exudative glomerulonephritis 10.7 CD40LG CD79A
29 salpingo-oophoritis 10.7 CD40LG CD79A
30 early yaws 10.7 CD40LG CD79A
31 ventilation pneumonitis 10.7 CD40LG CD79A
32 chronic interstitial cystitis 10.7 CD40LG CD79A
33 axillary adenitis 10.7 CD40LG CD79A
34 cryofibrinogenemia 10.7 CD40LG CD79A
35 ostertagiasis 10.7 ALB CD79A
36 dermatitis, atopic, 3 10.7 ALB CD79A
37 trichostrongyloidiasis 10.7 CD40LG CD79A
38 livedoid vasculopathy 10.7 CD40LG F2
39 subacute bacterial endocarditis 10.7 CD40LG CD79A
40 heterophyiasis 10.7 CD40LG CD79A
41 orbital granuloma 10.7 CD40LG CD79A
42 fournier gangrene 10.7 ALB CD40LG F2
43 transient hypogammaglobulinemia of infancy 10.7 CD40LG CD79A
44 hyperglobulinemic purpura 10.7 CD40LG CD79A
45 gastroduodenitis 10.7 CD40LG CD79A
46 hepatic tuberculosis 10.7 ALB ALPP F2
47 splenic disease 10.7 ALB CD40LG F2
48 bacterial conjunctivitis 10.7 CD40LG CD79A
49 hemorrhagic fever 10.6 ALB CD40LG F2
50 heavy chain disease 10.6 CD40LG CD79A

Comorbidity relations with Primary Biliary Cirrhosis via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Cholangitis Deficiency Anemia
Hepatic Encephalopathy Hypothyroidism
Portal Hypertension

Graphical network of the top 20 diseases related to Primary Biliary Cirrhosis:



Diseases related to Primary Biliary Cirrhosis

Symptoms & Phenotypes for Primary Biliary Cirrhosis

Drugs & Therapeutics for Primary Biliary Cirrhosis

Drugs for Primary Biliary Cirrhosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 130)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128-13-2 31401
2
chenodeoxycholic acid Approved Phase 4,Phase 3,Phase 2,Early Phase 1 474-25-9 10133
3
Abatacept Approved Phase 4 332348-12-6 10237
4 Liver Extracts Phase 4,Phase 3,Phase 2
5 Cholagogues and Choleretics Phase 4,Phase 3,Phase 2,Phase 1
6 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
7 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Cathartics Phase 4,Phase 3,Phase 2,Early Phase 1
9 Laxatives Phase 4,Phase 3,Phase 2,Early Phase 1
10 Immunosuppressive Agents Phase 4,Phase 3
11 methionine Nutraceutical Phase 4,Phase 2
12
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
13
Zidovudine Approved Phase 2, Phase 3 30516-87-1 35370
14
Tauroursodeoxycholic acid Approved, Investigational Phase 3 14605-22-2 12443252
15
Copper Approved, Investigational Phase 3 7440-50-8 27099
16
Molybdenum Approved Phase 3 7439-98-7 185498
17
Colchicine Approved Phase 3 64-86-8 2833 6167
18
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
19
Bezafibrate Approved, Investigational Phase 3 41859-67-0 39042
20
Fenofibrate Approved Phase 3,Phase 2,Phase 1 49562-28-9 3339
21
Budesonide Approved Phase 3,Phase 1 51333-22-3 5281004 63006
22
Metformin Approved Phase 2, Phase 3 657-24-9 4091 14219
23
Metronidazole Approved Phase 2, Phase 3 443-48-1 4173
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
25
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
26 Anti-HIV Agents Phase 2, Phase 3
27 Anti-Infective Agents Phase 2, Phase 3, Phase 1
28 Anti-Retroviral Agents Phase 2, Phase 3
29 Antiviral Agents Phase 2, Phase 3
30 Lamivudine, zidovudine drug combination Phase 2, Phase 3
31 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
32 Reverse Transcriptase Inhibitors Phase 2, Phase 3
33 Taurochenodeoxycholic Acid Phase 3
34 Angiogenesis Inhibitors Phase 3
35 Angiogenesis Modulating Agents Phase 3
36 Chelating Agents Phase 3
37 Micronutrients Phase 3
38 Tetrathiomolybdate Phase 3
39 Trace Elements Phase 3
40 Anticholesteremic Agents Phase 3,Phase 1
41 Antimetabolites Phase 3,Phase 2,Phase 1
42 Atorvastatin Calcium Phase 3 134523-03-8
43 Calcium, Dietary Phase 3
44 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
45 Hypolipidemic Agents Phase 3,Phase 2,Phase 1
46 Lipid Regulating Agents Phase 3,Phase 2,Phase 1
47 Antimetabolites, Antineoplastic Phase 3
48 Antimitotic Agents Phase 3
49 Dermatologic Agents Phase 3,Phase 2
50 Folic Acid Antagonists Phase 3

Interventional clinical trials:

(show top 50) (show all 97)

# Name Status NCT ID Phase Drugs
1 Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis Completed NCT02557360 Phase 4
2 Ursofalk Tablets (500 mg) Versus Ursofalk Capsules (250 mg) in the Treatment of Primary Biliary Cirrhosis Completed NCT01510860 Phase 4 UDCA (Ursodeoxycholic acid);UDCA (Ursodeoxycholic acid)
3 Phase 4 Study of Obeticholic Acid Evaluating Clinical Outcomes in Patients With Primary Biliary Cholangitis Recruiting NCT02308111 Phase 4 Obeticholic Acid (OCA);Placebo
4 Study of Abatacept (Orencia) to Treat Primary Biliary Cirrhosis Active, not recruiting NCT02078882 Phase 4
5 A Trial of 18-22mg/kg/d Ursodeoxycholic in Refractory Primary Biliary Cholangitis Not yet recruiting NCT03345589 Phase 4 18-22mg/kg/d Ursodeoxycholic;13-15mg/kg/d Ursodeoxycholic
6 Study of Combivir for Patients With Primary Biliary Cirrhosis Completed NCT00490620 Phase 2, Phase 3 Combination antiviral therapy;Placebo
7 Safety and Efficacy of Tauroursodeoxycholic Acid Versus Ursofalk in the Treatment of Adult Primary Biliary Cirrhosis Completed NCT01857284 Phase 3 Tauroursodeoxycholic Acid Capsules;Ursodeoxycholic Acid Capsules
8 Study Comparing Tetrathiomolybdate vs Standard Treatment in Primary Biliary Cirrhosis Completed NCT00805805 Phase 3 Tetrathiomolybdate
9 Safety and Efficacy of Long-Term Treatment With Atorvastatin in Patients With Primary Biliary Cirrhosis Completed NCT00844402 Phase 3 Atorvastatin
10 Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis Completed NCT00004748 Phase 3 colchicine;methotrexate;ursodiol
11 Phase 3 Study of Bezafibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Completed NCT01654731 Phase 3 Bezafibrate;placebo
12 Ursodiol-Methotrexate for Primary Biliary Cirrhosis Completed NCT00006168 Phase 3 Methotrexate
13 Phase III Randomized Study of Ursodiol With Vs Without Methotrexate for Primary Biliary Cirrhosis Completed NCT00004784 Phase 3 methotrexate;ursodiol
14 Efficacy and Safety Study of TUDCA Compare UDCA to Treatment Chronic Cholestatic Liver Disease-PBC Completed NCT01829698 Phase 3 tauroursodeoxycholic;ursodeoxycholic acid
15 Use of Bezafibrate in Patients With Primary Biliary Cirrhosis to Archive Complete Biochemical Response in Non-responders Recruiting NCT02937012 Phase 3 Bezafibrate;Ursodeoxycholic Acid;Placebo (for Bezafibrate)
16 Fenofibrate in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Recruiting NCT02823353 Phase 3 Fenofibrate;UDCA
17 Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) Recruiting NCT03301506 Phase 2, Phase 3 Seladelpar 2 mg Capsule;Seladelpar 5 mg Capsule;Seladelpar 10 mg Capsule
18 Fuzhenghuayu in Combination With Ursodeoxycholic Acid in Primary Biliary Cirrhosis Recruiting NCT02916290 Phase 3 Fuzhenghuayu;UDCA
19 Fenofibrate for Patients With Primary Biliary Cirrhosis Who Had An Inadequate Response to Ursodeoxycholic Acid Recruiting NCT02823366 Phase 3 Fenofibrate;UDCA
20 Fuzhenghuayu for Patients With PBC Who Had An Inadequate Response to Ursodeoxycholic Acid Recruiting NCT02916641 Phase 3 Fuzhenghuayu;UDCA
21 The Effect of Bezafibrate on Cholestatic Itch Recruiting NCT02701166 Phase 3 Bezafibrate;Placebo
22 Effectiveness of Ursodeoxycholic Acid Use in the Prevention of Gallstone Formation After Sleeve Gastrectomy Recruiting NCT02721862 Phase 3 Ursodeoxycholic Acid;Placebo
23 Phase 3 Study of Obeticholic Acid in Patients With Primary Biliary Cirrhosis Active, not recruiting NCT01473524 Phase 3 Obeticholic Acid (OCA);Placebo
24 Metformin in Intrahepatic Cholestasis of Pregnancy Not yet recruiting NCT03056274 Phase 2, Phase 3 Metformin;Ursodeoxycholic Acid
25 Ursodeoxycholic Acid Plus Budesonide Versus Ursodeoxycholic Acid Alone in Primary Biliary Cirrhosis (PBC) Terminated NCT00746486 Phase 3 budesonide;budesonide placebo
26 Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis Unknown status NCT01662973 Phase 1, Phase 2
27 Study of Rituximab in Patients With Steroid-Refractory Chronic Graft-Versus-Host Disease Unknown status NCT00472225 Phase 2 Rituximab
28 Moexipril for Primary Biliary Cirrhosis Completed NCT00588302 Phase 2 Moexipril
29 Initial Study of Rituximab to Treat Primary Biliary Cirrhosis Completed NCT00364819 Phase 1, Phase 2 rituximab
30 Use of Fenofibrate for Primary Biliary Cirrhosis Completed NCT00575042 Phase 2 Fenofibrate (Insoluble Drug Delivery-Micro Particle Fenofibrate (IDD-P)
31 A Study of Efficacy and Safety of Ustekinumab in Patients With Primary Biliary Cirrhosis (PBC) Who Had an Inadequate Response to Ursodeoxycholic Acid Completed NCT01389973 Phase 2 ustekinumab 90 mg;ustekinumab 45 mg;ustekinumab 180 mg;Placebo
32 Phase 2b Study of NGM282 Extended Treatment in Patients With Primary Biliary Cirrhosis Completed NCT02135536 Phase 2
33 Phase 2 Study of NGM282 in Patients With Primary Biliary Cirrhosis Completed NCT02026401 Phase 2
34 Pentoxifylline for Primary Biliary Cirrhosis Completed NCT01249092 Phase 2 Pentoxifylline
35 B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis Completed NCT02376335 Phase 2
36 Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis Completed NCT01904058 Phase 2 LUM001;Placebo;Ursodeoxycholic Acid
37 Phase 2 Study on Effects of Obeticholic Acid (OCA) on Lipoprotein Metabolism in Subjects With Primary Biliary Cirrhosis Completed NCT01865812 Phase 2 obeticholic acid (OCA)
38 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of Repeat Doses of GSK2330672 Administration in Subjects With Primary Biliary Cirrhosis (PBC) and Symptoms of Pruritus Completed NCT01899703 Phase 2 GSK2330672;Placebo;Ursodeoxycholic acid
39 Study of INT 747 in Combination With URSO in Patients With Primay Biliary Cirrhosis (PBC) Completed NCT00550862 Phase 2 INT-747;Ursodeoxycholic Acid (URSO);Placebo
40 Study of INT-747 as Monotherapy in Patients With PBC Completed NCT00570765 Phase 2 Placebo;INT-747;INT-747
41 Treatment of Cholestatic Pruritus With Sertraline Completed NCT00058903 Phase 2 sertraline
42 A Study to Evaluate Safety, Tolerability and Efficacy of Saroglitazar Magnesium in Patients With Primary Biliary Cholangitis (EPICS) Recruiting NCT03112681 Phase 2 Saroglitazar magnesium 2 mg;Saroglitazar magnesium 4 mg;Placebo Oral Tablet
43 Seladelpar (MBX-8025) in Subjects With Primary Biliary Cholangitis (PBC) Recruiting NCT02955602 Phase 2 MBX-8025 2 mg Capsule;MBX-8025 5 mg Capsule;MBX-8025 10 mg Capsule
44 Study to Assess Safety and Efficacy of GKT137831 in Patients With Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid. Recruiting NCT03226067 Phase 2 GKT137831;Placebo oral capsule
45 Study of E6011 in Japanese Subjects With Primary Biliary Cholangitis Inadequately Responding to Ursodeoxycholic Acid Recruiting NCT03092765 Phase 2 E6011;Placebo
46 Safety, Tolerability, and Efficacy of Etrasimod (APD334) in Patients With Primary Biliary Cholangitis Recruiting NCT03155932 Phase 2 APD334
47 A Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Primary Biliary Cholangitis Recruiting NCT03394924 Phase 2 EDP-305 Dose 1;EDP-305 Dose 2;Placebo
48 Safety, Tolerability, and Efficacy of GS 9674 in Adults With Primary Biliary Cholangitis Without Cirrhosis Recruiting NCT02943447 Phase 2 GS-9674;Placebo to match GS-9674
49 A Multi-part, Double Blind Study to Assess Safety, Tolerability and Efficacy of LJN452 in PBC Patients Recruiting NCT02516605 Phase 2 LJN452;Placebo
50 Study to Evaluate the Efficacy and Safety of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) and Inadequate Response to Ursodeoxycholic Acid Recruiting NCT03124108 Phase 2 Elafibranor 80 mg;Elafibranor 120 mg;Placebo

Search NIH Clinical Center for Primary Biliary Cirrhosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Primary Biliary Cirrhosis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: liver cirrhosis, biliary

Genetic Tests for Primary Biliary Cirrhosis

Genetic tests related to Primary Biliary Cirrhosis:

# Genetic test Affiliating Genes
1 Biliary Cirrhosis 28

Anatomical Context for Primary Biliary Cirrhosis

MalaCards organs/tissues related to Primary Biliary Cirrhosis:

38
Liver, T Cells, Bone, B Cells, Lung, Monocytes, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Primary Biliary Cirrhosis:
# Tissue Anatomical CompartmentCell Relevance
1 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Primary Biliary Cirrhosis

Articles related to Primary Biliary Cirrhosis:

(show top 50) (show all 1215)
# Title Authors Year
1
Lower Plasma Levels of IL-35 in Patients with Primary Biliary Cirrhosis. ( 29445068 )
2018
2
Palmoplantar keratoderma as a presenting sign of primary biliary cirrhosis. ( 29270458 )
2018
3
[Single nucleotide polymorphism of STAT4 rs7574865 is associated with the susceptibility of primary biliary cirrhosis in Han population of partial regions of Jiangsu province]. ( 28395724 )
2017
4
Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis. ( 29113177 )
2017
5
A Case of Primary Biliary Cirrhosis Mimicking Acute Hepatitis B in the Clinic, Republic of Korea. ( 28197333 )
2017
6
Clinical relevance of combined anti-mitochondrial M2 detection assays for primary biliary cirrhosis. ( 27864100 )
2017
7
Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury. ( 28823616 )
2017
8
Successful infliximab therapy in a patient with comorbid spondyloarthritis, primary biliary cirrhosis and generalized morphea. ( 28229620 )
2017
9
Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis. ( 28570655 )
2017
10
Fungal infection involvement in primary biliary cirrhosis: A review of 2 cases. ( 28352320 )
2017
11
Xanthoma Striatum Palmare in a Patient of Primary Biliary Cirrhosis with Autoimmune Hepatitis. ( 28566919 )
2017
12
Interstitial granulomatous dermatitis associated with primary biliary cirrhosis. ( 28225148 )
2017
13
Concurrent Occurrence of Primary Biliary Cirrhosis and Rheumatoid Arthritis. ( 29057174 )
2017
14
Autoimmune Hepatitis - Primary Biliary Cirrhosis Overlap Syndrome. ( 28892963 )
2017
15
Prediction of oesophageal varices in patients with primary biliary cirrhosis by non-invasive markers. ( 28261290 )
2017
16
Primary Biliary Cholangitis (Primary Biliary Cirrhosis) ( 29083627 )
2017
17
Spontaneous Splenic Infarcts in a Cirrhotic Patient with Primary Biliary Cirrhosis. ( 28203139 )
2017
18
Subtle presentation of active primary biliary cirrhosis in chronic hepatitis B: a case report. ( 26893441 )
2016
19
A Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety: Modafinil in the Treatment of Fatigue in Patients With Primary Biliary Cirrhosis. ( 27148676 )
2016
20
A Systems Model for Ursodeoxycholic Acid Metabolism in Healthy and Patients With Primary Biliary Cirrhosis. ( 27537780 )
2016
21
Primary Biliary Cirrhosis Beyond Ursodeoxycholic Acid. ( 26870929 )
2016
22
Primary biliary cirrhosis associated with Graves' disease in a male patient. ( 26935935 )
2016
23
Red blood cell distribution width and mean platelet volume are potential prognostic indices for patients with primary biliary cirrhosis. ( 27754960 )
2016
24
Metabolic Bone Disease in Primary Biliary Cirrhosis. ( 27261902 )
2016
25
Serum proteomic signatures as biomarkers of primary biliary cirrhosis diagnosis and prognosis. ( 27707675 )
2016
26
Cutaneous Metastasis due to Breast Cancer in a Patient with Primary Biliary Cirrhosis: A Case Report. ( 27920708 )
2016
27
A systematic approach to the management of cholestatic pruritus in primary biliary cirrhosis. ( 28839853 )
2016
28
The relationship between liver histology and noninvasive markers in primary biliary cirrhosis. ( 27092904 )
2016
29
Primary biliary cirrhosis degree assessment by acoustic radiation force impulse imaging and hepatic fibrosis indicators. ( 27298571 )
2016
30
Interleukin-17A-Induced Epithelial-Mesenchymal Transition of Human Intrahepatic Biliary Epithelial Cells: Implications for Primary Biliary Cirrhosis. ( 27916760 )
2016
31
Impact of Microbes on the Pathogenesis of Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC). ( 27834858 )
2016
32
A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. ( 26842849 )
2016
33
Insight into the natural history of primary biliary cirrhosis: A systemic review of data from placebo-controlled clinical trials. ( 27458850 )
2016
34
Editorial: improved understanding of the epidemiology of primary biliary cirrhosis in South Korea. ( 26843341 )
2016
35
A Case of Frontal Fibrosing Alopecia in a Patient with Primary Biliary Cirrhosis and Polymyalgia Rheumatica. ( 27843932 )
2016
36
Identification of microRNA profiles associated with refractory primary biliary cirrhosis. ( 27511723 )
2016
37
Low Incidence of Primary Biliary Cirrhosis (PBC) in First Degree Relatives of PBC Probands after 8 Years of Follow Up. ( 27062298 )
2016
38
Clinical characteristics of drug-induced liver injury and primary biliary cirrhosis. ( 27672278 )
2016
39
A case of primary biliary cirrhosis. ( 27728258 )
2016
40
Bile Acids and the Potential Role in Primary Biliary Cirrhosis. ( 27832649 )
2016
41
A rare nonsynonymous variant in the lipid metabolic gene HELZ2 related to primary biliary cirrhosis in Chinese Han. ( 27047549 )
2016
42
Association of IL12A Expression Quantitative Trait Loci (eQTL) With Primary Biliary Cirrhosis in a Chinese Han Population. ( 27175695 )
2016
43
Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis: an Update on MR Imaging Findings with Recent Developments. ( 27981308 )
2016
44
Liver fibrosis progression predicts survival in patients with primary biliary cirrhosis. ( 27189879 )
2016
45
BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial. ( 27431238 )
2016
46
Primary biliary cirrhosis has high wait-list mortality among patients listed for liver transplantation. ( 27754570 )
2016
47
A Patient With Primary Biliary Cirrhosis Accompanied by Wilson's Disease. ( 27148382 )
2016
48
Obeticholic acid for the treatment of primary biliary cirrhosis. ( 27589928 )
2016
49
Autoimmune haemolytic anaemia is a rare association with primary biliary cirrhosis. ( 27269759 )
2016
50
Clinical Course and Genetic Susceptibility of Primary Biliary Cirrhosis: Analysis of a Prospective Cohort. ( 28070198 )
2016

Variations for Primary Biliary Cirrhosis

Expression for Primary Biliary Cirrhosis

Search GEO for disease gene expression data for Primary Biliary Cirrhosis.

Pathways for Primary Biliary Cirrhosis

Pathways related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.98 ABCB4 NR1H4 SLC4A2
2
Show member pathways
10.41 DBT DLAT PDHX

GO Terms for Primary Biliary Cirrhosis

Cellular components related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyruvate dehydrogenase complex GO:0045254 8.62 DLAT PDHX

Biological processes related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of acetyl-CoA biosynthetic process from pyruvate GO:0010510 8.96 DLAT PDHX
2 cellular nitrogen compound metabolic process GO:0034641 8.8 DBT DLAT PDHX

Molecular functions related to Primary Biliary Cirrhosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromo shadow domain binding GO:0070087 8.96 LBR SP100
2 pyruvate dehydrogenase (NAD+) activity GO:0034604 8.62 DLAT PDHX

Sources for Primary Biliary Cirrhosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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