MCID: PRM155
MIFTS: 50

Primary Cutaneous Anaplastic Large Cell Lymphoma malady

Skin diseases, Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories

Summaries for Primary Cutaneous Anaplastic Large Cell Lymphoma

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MalaCards based summary: Primary Cutaneous Anaplastic Large Cell Lymphoma, also known as lymphoma, primary cutaneous anaplastic large cell, is related to anaplastic large cell lymphoma and lymphomatoid papulosis, and has symptoms including pruritus, lymphoma and skin ulcer. An important gene associated with Primary Cutaneous Anaplastic Large Cell Lymphoma is IRF4 (interferon regulatory factor 4), and among its related pathways are IL4-mediated signaling events and Cytokine production by Th17 cells in CF. The compounds dasatinib and gp 130 have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and myeloid, and related mouse phenotypes are tumorigenesis and respiratory system.

Aliases & Classifications for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Sources:
49Orphanet, 62UMLS, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Primary Cutaneous Anaplastic Large Cell Lymphoma, Aliases & Descriptions:

Name: Primary Cutaneous Anaplastic Large Cell Lymphoma 49
Lymphoma, Primary Cutaneous Anaplastic Large Cell 62
 
Regressive Atypical Histiocytosis 49
Primary C-Alcl 49


Classifications:



Characteristics (Orphanet epidemiological data):

49
primary cutaneous anaplastic large cell lymphoma:
Age of onset: Adolescent,Adult,Childhood; Age of death: adult


External Ids:

Orphanet49 300865
ICD10 via Orphanet28 C86.6
UMLS via Orphanet63 C1301362, C1698767

Related Diseases for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma32.0ALK, CCR4, STAT3
2lymphomatoid papulosis31.3CCR4, ALK
3mycosis fungoides31.0TRG, STAT3, CCR4
4leukemia30.5STAT5B, STAT3, ALK, CD44, TRG, IRF4
5burn scar10.6
6burns10.6
7histiocytosis10.4
8hepatitis c virus10.4
9hemophagocytic lymphohistiocytosis10.4
10hepatitis10.4
11sinusitis10.4
12hepatitis c10.4
13atopic dermatitis10.4
14cerebritis10.4
15basal cell carcinoma10.4
16dermatitis10.4
17keratosis10.4
18myeloid leukemia10.4
19pneumonia10.4
20syndrome of inappropriate antidiuretic hormone10.4
21endotheliitis10.4
22burkitt lymphoma10.0ALK, TRG
23reticulosarcoma10.0CCR4, ALK
24leukemia, acute promyelocytic10.0STAT5B, STAT3
25cutaneous t cell lymphoma10.0STAT3, CCR4, TRG
26leukemia, acute lymphoblastic10.0IRF4, STAT5B, TRG
27squamous cell carcinoma, head and neck10.0STAT3, STAT5B
28peripheral t-cell lymphoma10.0ALK, TRG, CCR4
29t-cell leukemia10.0IRF4, CCR4, STAT3
30hematologic cancer10.0STAT5B, ALK
31colitis10.0STAT5B, STAT3
32thyroid carcinoma, papillary10.0STAT3, CD44
33lymphoma, non-hodgkin10.0CD44, ALK, IRF4
34rheumatoid arthritis10.0TRG, CD44, CCR4
35hodgkin lymphoma10.0STAT3, ALK, CCR4, IRF4
36chronic lymphocytic leukemia10.0CD44, STAT3
37glioblastoma multiforme10.0STAT3, ALK, CD44
38brain cancer10.0CD44, STAT3, ALK
39glioblastoma10.0CD44, STAT3, ALK
40lung cancer10.0CD44, STAT3, ALK
41prostate cancer9.9STAT5B, TRG, STAT3, CD44
42myeloma9.9STAT3, ALK, IRF4, CD44
43b-cell lymphomas9.9IRF4, CD44, TRG, ALK, STAT3
44melanoma9.9CD44, CCR4, STAT3, IRF4, STAT5B

Graphical network of the top 20 diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma:



Diseases related to primary cutaneous anaplastic large cell lymphoma

Symptoms for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Symptoms:

 49 (show all 9)
  • chronic skin infection/ulcerations/ulcers/cancrum
  • follicular/erythematous/edematous papules/milium
  • pruritus/itching
  • lymphoma
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • lymphadenopathy/polyadenopathies
  • hyperhidrosis/increased sweating
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • asthenia/fatigue/weakness

HPO human phenotypes related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

(show all 6)
id Description Frequency HPO Source Accession
1 pruritus hallmark (90%) HP:0000989
2 lymphoma hallmark (90%) HP:0002665
3 skin ulcer hallmark (90%) HP:0200042
4 lymphadenopathy typical (50%) HP:0002716
5 hyperhidrosis occasional (7.5%) HP:0000975
6 weight loss occasional (7.5%) HP:0001824

Drugs & Therapeutics for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Primary Cutaneous Anaplastic Large Cell Lymphoma

Search NIH Clinical Center for Primary Cutaneous Anaplastic Large Cell Lymphoma

Genetic Tests for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Anatomical Context for Primary Cutaneous Anaplastic Large Cell Lymphoma

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MalaCards organs/tissues related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

33
Skin, T cells, Myeloid, B cells, Endothelial, Neutrophil

Animal Models for Primary Cutaneous Anaplastic Large Cell Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6CD44, STAT3, STAT5B, IRF4
2MP:00053888.3CCR4, STAT3, STAT5B, CD44
3MP:00028738.1STAT5B, CD44, TRG, STAT3
4MP:00107717.8TRG, CD44, STAT3, STAT5B
5MP:00053977.3CCR4, CD44, STAT3, STAT5B, IRF4, TRG
6MP:00053877.3STAT5B, TRG, IRF4, CD44, CCR4, STAT3

Publications for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Articles related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

(show top 50)    (show all 71)
idTitleAuthorsYear
1
Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule. (25633507)
2015
2
Hemophagocytic lymphohistiocytosis in association with primary cutaneous anaplastic large cell lymphoma. (25405042)
2014
3
Keratosis lichenoides chronica in association with primary cutaneous anaplastic large cell lymphoma. (23228152)
2014
4
Composite Mantle Cell and Primary Cutaneous Anaplastic Large Cell Lymphoma: Case Report and Review of the Literature. (25374307)
2014
5
Congenital Primary Cutaneous Anaplastic Large-Cell Lymphoma: A Case Report. (25365497)
2014
6
Remission of primary cutaneous anaplastic large cell lymphoma after a brief course of brentuximab vedotin. (23086510)
2013
7
Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report. (24099147)
2013
8
Primary cutaneous anaplastic large cell lymphoma simulating an aggressive angiocentric T-cell lymphoma. (22458926)
2013
9
Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Intralesional Methotrexate Therapy. (24002114)
2013
10
Primary cutaneous anaplastic large-cell lymphoma occurring in a case of chronic myeloid leukemia in remission. (22775801)
2012
11
A case of primary cutaneous anaplastic large cell lymphoma with prominent epidermotropism. (22450880)
2012
12
HIV-associated primary cutaneous anaplastic large cell lymphoma: aA clinicopathological subset with more aggressive behavior? Case report and review of the literature. (23061973)
2012
13
Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides. (22776000)
2012
14
Primary cutaneous anaplastic large cell lymphoma arising from a burn scar. (22481116)
2012
15
Syndrome of inappropriate antidiuretic hormone secretion associated with primary cutaneous anaplastic large cell lymphoma. (22409317)
2012
16
Primary cutaneous anaplastic large-cell lymphoma of the eyelid. (21464784)
2012
17
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (21841159)
2011
18
Primary cutaneous anaplastic large cell lymphoma of the nasal tip in a child. (20825571)
2011
19
CD8-positive primary cutaneous anaplastic large cell lymphoma presenting as multiple scrotal nodules and plaques. (21680287)
2011
20
Anaplastic lymphoma kinase expression in a recurrent primary cutaneous anaplastic large cell lymphoma with eventual systemic involvement. (21839333)
2011
21
Perils and pitfalls regarding differential diagnosis and treatment of primary cutaneous anaplastic large-cell lymphoma. (21552770)
2011
22
Primary cutaneous anaplastic large-cell lymphoma. (21163153)
2010
23
Primary cutaneous anaplastic large-cell lymphoma presenting with hemophagocytic syndrome: a case report and review of the literature. (19640585)
2010
24
Pagetoid reticulosis after radiotherapy of primary cutaneous anaplastic large-cell lymphoma. (19940753)
2010
25
Pyogenic variant of primary cutaneous anaplastic large-cell lymphoma: a lymphoproliferative disorder with a predilection for the immunocompromized and the young. (20881832)
2010
26
Primary cutaneous anaplastic large cell lymphoma: a clinicopathologic analysis of 8 cases]. (20079014)
2009
27
Neutrophil/eosinophil-rich type of primary cutaneous anaplastic large cell lymphoma: a clinicopathological, immunophenotypic and molecular study of nine cases. (19694826)
2009
28
CD30-positive primary cutaneous anaplastic large-cell lymphoma and definite squamous cell carcinoma. (19456793)
2009
29
Prognostic factors in primary cutaneous anaplastic large cell lymphoma: characterization of clinical subset with worse outcome. (19528422)
2009
30
MUM1 expression does not differentiate primary cutaneous anaplastic large-cell lymphoma and lymphomatoid papulosis. (19301457)
2009
31
Primary cutaneous anaplastic large cell lymphoma of the vulva: a typical cutaneous lesion with an 'atypical' presenting site. (19707712)
2009
32
Primary cutaneous anaplastic large cell lymphoma arising from lymphomatoid papulosis, responding to low dose methotrexate. (20808598)
2009
33
Differential diagnosis and treatment of primary, cutaneous, anaplastic large cell lymphoma: not always an easy task. (19548068)
2009
34
Primary cutaneous anaplastic large cell lymphoma successfully treated with local thermotherapy using pocket hand warmers. (19120772)
2008
35
MUM1 expression in cutaneous CD30+ lymphoproliferative disorders: a valuable tool for the distinction between lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (18410414)
2008
36
Inhibition of the mammalian target of rapamycin (mTOR) in a case of refractory primary cutaneous anaplastic large cell lymphoma. (18231928)
2008
37
Coexistence of primary cutaneous anaplastic large cell lymphoma and mycosis fungoides in a patient with B-cell chronic lymphocytic leukaemia. (17927791)
2007
38
Successful treatment for recurrence of primary cutaneous anaplastic large-cell lymphoma in elderly patient with etoposide, mitoxantrone, cyclophosphamide, vincristine, prednisolone and bleomycin (VNCOP-B) therapy. (17683387)
2007
39
Primary cutaneous anaplastic large cell lymphoma with fatal leukemic outcome in association with CLA and CCR4-negative conversion. (17938033)
2007
40
Fulminant cutaneous eruption in a 51-year-old man. Primary cutaneous anaplastic large cell lymphoma (C-ALCL). (17310010)
2007
41
Primary cutaneous anaplastic large cell lymphoma associated with vascular endothelial growth factor arising from a burn scar. (17938017)
2007
42
T-cell primary cutaneous anaplastic large cell lymphoma mimicking appearance of large basal cell carcinoma. (16815209)
2006
43
Primary cutaneous anaplastic large cell lymphoma in an elderly patient with cryoglobulinaemic hepatitis C virus infection. (15491453)
2004
44
Evidence for polyclonal infection of Epstein-Barr virus in a patient with primary cutaneous anaplastic large cell lymphoma. (15245536)
2004
45
A case of primary cutaneous anaplastic large cell lymphoma with variant anaplastic lymphoma kinase translocation. (15214912)
2004
46
CD30+ cutaneous lymphoproliferative disorders: the Stanford experience in lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma. (14639383)
2003
47
Co-existent primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis. (14616830)
2003
48
Association of expression of CD44v6 with systemic anaplastic large cell lymphoma: comparison with primary cutaneous anaplastic large cell lymphoma. (11863224)
2002
49
Primary cutaneous anaplastic large cell lymphoma in a young girl. (11730060)
2001
50
Carbamazepine-induced, CD30+, primary, cutaneous, anaplastic large-cell lymphoma. (11346361)
2001

Variations for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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Search GEO for disease gene expression data for Primary Cutaneous Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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Pathways related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IRF4, STAT5B
2
Show member pathways
9.5IRF4, STAT3
3
Show member pathways
IL-2 Signaling pathway38
9.4STAT5B, STAT3
49.4STAT5B, STAT3
5
Show member pathways
9.4STAT5B, STAT3
6
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)38
9.4STAT5B, STAT3
7
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.4STAT5B, STAT3
8
Show member pathways
9.4STAT5B, STAT3
9
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.4STAT5B, STAT3
10
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.4STAT5B, STAT3
11
Show member pathways
EPO Receptor Signaling38
EPO signaling pathway38
9.4STAT5B, STAT3
129.4STAT5B, STAT3
13
Show member pathways
9.4STAT5B, STAT3
149.4STAT3, STAT5B
159.4STAT3, STAT5B
169.4STAT3, STAT5B
17
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
9.4STAT3, STAT5B
18
Show member pathways
9.4STAT3, STAT5B
199.4STAT3, STAT5B
20
Show member pathways
9.4STAT3, STAT5B
219.4STAT3, STAT5B
229.4STAT3, STAT5B
23
Show member pathways
9.4STAT3, STAT5B
249.4STAT3, STAT5B
259.4STAT3, STAT5B
26
Show member pathways
IL27-mediated signaling events38
9.4STAT3, STAT5B
27
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
9.3CD44, STAT3
289.1STAT3, STAT5B, IRF4
29
Show member pathways
9.0ALK, STAT3, STAT5B
30
Show member pathways
9.0ALK, STAT3, STAT5B
31
Show member pathways
8.9CCR4, STAT3, STAT5B
32
Show member pathways
8.9STAT5B, STAT3, CCR4
338.9STAT5B, STAT3, CCR4
34
Show member pathways
8.5CD44, STAT3, STAT5B, IRF4
35
Show member pathways
8.5ALK, CCR4, STAT3, STAT5B
36
Show member pathways
8.5STAT5B, STAT3, CCR4, ALK
37
Show member pathways
8.5STAT5B, STAT3, CCR4, ALK

Compounds for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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Compounds related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1dasatinib45 51 1311.6STAT5B, STAT3
2gp 130459.4STAT3, STAT5B
3phosphotyrosine459.2STAT5B, STAT3, ALK
4[alcl]459.2ALK, CCR4, STAT3
5ly294002459.0CD44, STAT3, STAT5B
6rantes459.0CD44, CCR4, STAT3
7doxorubicin45 51 1310.9STAT3, ALK, CD44
8cycloheximide458.9CD44, STAT3, STAT5B
9phosphatidylinositol458.7STAT5B, STAT3, ALK, CD44
10alanine458.7STAT5B, STAT3, ALK, CD44
11paraffin458.6CD44, ALK, CCR4, STAT3
12retinoic acid45 269.6CD44, CCR4, STAT3, STAT5B
13serine458.4STAT5B, STAT3, ALK, CD44
14tyrosine458.2STAT5B, STAT3, CCR4, ALK, CD44
15testosterone45 61 26 1311.2TRG, CD44, STAT3

GO Terms for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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Biological processes related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-2 biosynthetic processGO:00450869.9STAT5B, IRF4
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:00603979.6STAT5B, STAT3
3regulation of multicellular organism growthGO:00400149.6STAT5B, STAT3
4phosphorylationGO:00163109.6ALK, STAT3
5JAK-STAT cascadeGO:00072599.6STAT5B, STAT3
6cellular response to hormone stimulusGO:00328709.5STAT3, STAT5B
7interferon-gamma-mediated signaling pathwayGO:00603339.5IRF4, CD44
8acute-phase responseGO:00069539.4STAT3, STAT5B
9response to ethanolGO:00454719.4STAT3, STAT5B
10cytokine-mediated signaling pathwayGO:00192219.2CD44, STAT3, IRF4
11response to estradiolGO:00323559.1STAT3, STAT5B

Molecular functions related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:00199039.4STAT3, STAT5B
2glucocorticoid receptor bindingGO:00352599.1STAT3, STAT5B

Products for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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Sources for Primary Cutaneous Anaplastic Large Cell Lymphoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet