MCID: PRM155
MIFTS: 35

Primary Cutaneous Anaplastic Large Cell Lymphoma malady

Skin diseases, Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Primary Cutaneous Anaplastic Large Cell Lymphoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 CD30+ cutaneous T-cell lymphoma (also known as \"Primary cutaneous anaplastic large cell lymphoma\") is... more...

MalaCards: Primary Cutaneous Anaplastic Large Cell Lymphoma, also known as lymphoma, primary cutaneous anaplastic large cell, is related to anaplastic large cell lymphoma and cutaneous t cell lymphoma. An important gene associated with Primary Cutaneous Anaplastic Large Cell Lymphoma is IRF4 (interferon regulatory factor 4), and among its related pathways are IL4-mediated signaling events and Cytokine production by Th17 cells in CF (Mouse model). The compounds dasatinib and rantes have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related mouse phenotypes are tumorigenesis and respiratory system.

Aliases & Classifications for Primary Cutaneous Anaplastic Large Cell Lymphoma

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48Orphanet, 60UMLS, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Blood diseases, Immune diseases


Aliases & Descriptions:

primary cutaneous anaplastic large cell lymphoma 48
lymphoma, primary cutaneous anaplastic large cell 60
regressive atypical histiocytosis 48
primary c-alcl 48


External Ids:

SNOMED-CT via Orphanet57 128875000, 397352006
ICD10 via Orphanet26 C86.6

Related Diseases for Primary Cutaneous Anaplastic Large Cell Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma31.8ALK, STAT3, CCR4
2cutaneous t cell lymphoma30.7CCR4, STAT3, TRG
3mycosis fungoides30.7TRG, STAT3, CCR4
4myeloid leukemia30.5STAT3, STAT5B
5leukemia30.5IRF4, STAT5B, STAT3, TRG, CD44, ALK
6hodgkin's lymphoma30.2ALK, STAT3, IRF4, CCR4
7burn scar10.5
8burns10.5
9large cell carcinoma10.5
10histiocytosis10.4
11hepatitis c10.4
12cerebritis10.4
13orbit lymphoma10.4
14chronic myeloid leukemia10.4
15cerebral lymphoma10.4
16basal cell carcinoma10.4
17hepatitis10.4
18keratosis10.4
19pneumonia10.4
20squamous cell carcinoma10.4
21multiple sclerosis10.0CCR4
22rhabdomyosarcoma10.0ALK
23sarcoidosis10.0CCR4
24asthma10.0CCR4
25chronic myeloproliferative disease10.0STAT3
26lymphomatoid papulosis10.0ALK, CCR4
27reticulosarcoma10.0ALK, CCR4
28burkitt's lymphoma10.0ALK, TRG
29peripheral t-cell lymphoma10.0CCR4, TRG, ALK
30acute lymphocytic leukemia10.0TRG, STAT5B, IRF4
31t-cell leukemia10.0STAT3, IRF4, CCR4
32lung cancer10.0CD44, ALK
33papillary thyroid carcinoma10.0CD44, STAT3
34non-hodgkin lymphoma10.0ALK, CD44, IRF4
35brain cancer10.0STAT3, CD44, ALK
36glioblastoma multiforme10.0ALK, CD44, STAT3
37prostate cancer10.0CD44, TRG, STAT3, STAT5B
38myeloma10.0ALK, CD44, STAT3, IRF4
39non-small cell lung carcinoma10.0ALK, CD44, STAT3
40b-cell lymphomas10.0IRF4, STAT3, TRG, CD44, ALK
41melanoma10.0CCR4, IRF4, STAT5B, STAT3, CD44

Graphical network of the top 20 diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma:



Diseases related to primary cutaneous anaplastic large cell lymphoma

Clinical Features for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Drugs & Therapeutics for Primary Cutaneous Anaplastic Large Cell Lymphoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Primary Cutaneous Anaplastic Large Cell Lymphoma

Search CenterWatch for Primary Cutaneous Anaplastic Large Cell Lymphoma

Genetic Tests for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Anatomical Context for Primary Cutaneous Anaplastic Large Cell Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

32
Skin, T cells

Animal Models for Primary Cutaneous Anaplastic Large Cell Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8STAT5B
2MP:00053888.9CD44, STAT3, STAT5B
3MP:00053977.2CD44, TRG, STAT3, STAT5B, IRF4, CCR4
4MP:00053877.1CCR4, IRF4, STAT5B, STAT3, TRG, CD44

Publications for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Genetic Variations for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Primary Cutaneous Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 53Reactome, 4Cell Signaling Technology, 51QIAGEN, 29KEGG
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Pathways related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IRF4, STAT5B
2
Cytokine production by Th17 cells in CF (Mouse model)
9.6STAT3, IRF4
3
Development EPO-induced Jak-STAT pathway
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9.5STAT3, STAT5B
4
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9.5STAT5B, STAT3
59.5STAT3, STAT5B
6
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9.5STAT3, STAT5B
7
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9.5STAT5B, STAT3
89.5STAT3, STAT5B
99.5STAT5B, STAT3
109.5STAT3, STAT5B
119.5STAT3, STAT5B
129.5STAT3, STAT5B
13
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9.5STAT3, STAT5B
14
Development Thrombopoetin signaling via JAK-STAT pathway
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9.5STAT3, STAT5B
15
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.5STAT3, STAT5B
169.5STAT5B, STAT3
179.5STAT3, STAT5B
189.5STAT3, STAT5B
19
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9.5STAT3, STAT5B
209.2STAT3, STAT5B, IRF4
218.7STAT3, STAT5B, CCR4
22
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8.7CCR4, STAT5B, STAT3
23
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8.5CD44, STAT3, STAT5B, IRF4
248.5IRF4, STAT5B, STAT3, CD44
25
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8.3CCR4, STAT5B, STAT3, ALK
26
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8.3CCR4, STAT5B, STAT3, ALK
27
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8.3ALK, STAT3, STAT5B, CCR4

Compounds for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1dasatinib44 49 1111.6STAT3, STAT5B
2rantes449.5CD44, STAT3
3phosphotyrosine449.1ALK, STAT3, STAT5B
4[alcl]448.9ALK, STAT3, CCR4
5doxorubicin44 49 1110.9ALK, CD44, STAT3
6phosphatidylinositol448.6STAT5B, STAT3, CD44, ALK
7ly294002448.6CD44, STAT3, STAT5B
8alanine448.6STAT5B, STAT3, CD44, ALK
9paraffin448.3ALK, CD44, STAT3, CCR4
10retinoic acid44 249.0CCR4, STAT5B, STAT3, CD44
11tyrosine447.8CCR4, STAT5B, STAT3, CD44, ALK

GO Terms for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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16Gene Ontology
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Biological processes related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-2 biosynthetic processGO:0450869.9STAT5B, IRF4
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.7STAT5B, STAT3
3cellular response to hormone stimulusGO:0328709.7STAT5B, STAT3
4regulation of multicellular organism growthGO:0400149.7STAT5B, STAT3
5JAK-STAT cascadeGO:0072599.6STAT5B, STAT3
6phosphorylationGO:0163109.5ALK, STAT3
7interferon-gamma-mediated signaling pathwayGO:0603339.5CD44, IRF4
8acute-phase responseGO:0069539.4STAT5B, STAT3
9response to estradiol stimulusGO:0323559.2STAT3, STAT5B
10cytokine-mediated signaling pathwayGO:0192219.2CD44, STAT3, IRF4

Molecular functions related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucocorticoid receptor bindingGO:0352599.5STAT3, STAT5B

Products for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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  • Antibodies
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  • Antibodies

Sources for Primary Cutaneous Anaplastic Large Cell Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet