MCID: PRM155
MIFTS: 46

Primary Cutaneous Anaplastic Large Cell Lymphoma malady

Skin diseases, Blood diseases, Cancer diseases, Rare diseases, Immune diseases categories

Summaries for Primary Cutaneous Anaplastic Large Cell Lymphoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 CD30+ cutaneous T-cell lymphoma (also known as \"Primary cutaneous anaplastic large cell lymphoma\") is... more...

MalaCards: Primary Cutaneous Anaplastic Large Cell Lymphoma, also known as lymphoma, primary cutaneous anaplastic large cell, is related to anaplastic large cell lymphoma and lymphomatoid papulosis. An important gene associated with Primary Cutaneous Anaplastic Large Cell Lymphoma is IRF4 (interferon regulatory factor 4), and among its related pathways are IL4-mediated signaling events and Cytokine production by Th17 cells in CF. The compounds dasatinib and gp 130 have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and myeloid, and related mouse phenotypes are tumorigenesis and respiratory system.

Aliases & Classifications for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Sources:
50Orphanet, 63UMLS, 64UMLS via Orphanet, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
primary cutaneous anaplastic large cell lymphoma:
Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

primary cutaneous anaplastic large cell lymphoma 50
lymphoma, primary cutaneous anaplastic large cell 63
regressive atypical histiocytosis 50
primary c-alcl 50


External Ids:

UMLS via Orphanet64 C1301362, C1698767
SNOMED-CT via Orphanet60 128875000, 397352006
ICD10 via Orphanet27 C86.6

Related Diseases for Primary Cutaneous Anaplastic Large Cell Lymphoma

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18GeneCards, 19GeneDecks
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Diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma31.9ALK, CCR4, STAT3
2lymphomatoid papulosis31.3ALK, CCR4
3mycosis fungoides30.8STAT3, CCR4, TRG
4leukemia30.3IRF4, STAT5B, STAT3, ALK, CD44, TRG
5hodgkin's lymphoma30.2ALK, CCR4, STAT3, IRF4
6burn scar10.5
7burns10.5
8histiocytosis10.4
9hepatitis c10.4
10chronic myeloid leukemia10.4
11cerebritis10.4
12basal cell carcinoma10.4
13hepatitis10.4
14keratosis10.4
15myeloid leukemia10.4
16pneumonia10.4
17syndrome of inappropriate antidiuretic hormone10.4
18hepatitis c virus10.4
19sinusitis10.4
20endotheliitis10.4
21burkitt's lymphoma10.0TRG, ALK
22reticulosarcoma10.0ALK, CCR4
23cutaneous t cell lymphoma10.0STAT3, CCR4, TRG
24acute promyelocytic leukemia10.0STAT3, STAT5B
25acute lymphocytic leukemia10.0TRG, STAT5B, IRF4
26peripheral t-cell lymphoma10.0CCR4, ALK, TRG
27t-cell leukemia10.0IRF4, STAT3, CCR4
28hematologic cancer10.0ALK, STAT5B
29papillary thyroid carcinoma10.0CD44, STAT3
30non-hodgkin lymphoma9.9IRF4, ALK, CD44
31b-cell chronic lymphocytic leukemia9.9CD44, STAT3
32brain cancer9.9CD44, ALK, STAT3
33rheumatoid arthritis9.9TRG, CD44, CCR4
34glioblastoma multiforme9.9CD44, ALK, STAT3
35non-small cell lung carcinoma9.9STAT3, ALK, CD44
36prostate cancer9.9STAT5B, STAT3, CD44, TRG
37myeloma9.9CD44, ALK, STAT3, IRF4
38b-cell lymphomas9.9IRF4, STAT3, ALK, CD44, TRG
39melanoma9.9IRF4, STAT5B, STAT3, CCR4, CD44
40lung cancer9.8CD44, ALK, CCR4, STAT3, STAT5B

Graphical network of the top 20 diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma:



Diseases related to primary cutaneous anaplastic large cell lymphoma

Symptoms for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Drugs & Therapeutics for Primary Cutaneous Anaplastic Large Cell Lymphoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Primary Cutaneous Anaplastic Large Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Primary Cutaneous Anaplastic Large Cell Lymphoma

Search NIH Clinical Center for Primary Cutaneous Anaplastic Large Cell Lymphoma

Search CenterWatch for Primary Cutaneous Anaplastic Large Cell Lymphoma

Genetic Tests for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Anatomical Context for Primary Cutaneous Anaplastic Large Cell Lymphoma

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34MalaCards
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MalaCards organs/tissues related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

34
T cells, Skin, Myeloid, B cells, Endothelial

Animal Models for Primary Cutaneous Anaplastic Large Cell Lymphoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6IRF4, STAT5B, STAT3, CD44
2MP:00053888.3CD44, CCR4, STAT3, STAT5B
3MP:00028738.1TRG, CD44, STAT3, STAT5B
4MP:00107717.8STAT5B, STAT3, CD44, TRG
5MP:00053977.3TRG, CD44, CCR4, STAT3, STAT5B, IRF4
6MP:00053877.3IRF4, STAT5B, STAT3, CCR4, CD44, TRG

Publications for Primary Cutaneous Anaplastic Large Cell Lymphoma

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53PubMed
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Articles related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Keratosis lichenoides chronica in association with primary cutaneous anaplastic large cell lymphoma. (23228152)
2014
2
Remission of primary cutaneous anaplastic large cell lymphoma after a brief course of brentuximab vedotin. (23086510)
2013
3
Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report. (24099147)
2013
4
Primary cutaneous anaplastic large cell lymphoma simulating an aggressive angiocentric T-cell lymphoma. (22458926)
2013
5
Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Intralesional Methotrexate Therapy. (24002114)
2013
6
Primary cutaneous anaplastic large-cell lymphoma occurring in a case of chronic myeloid leukemia in remission. (22775801)
2012
7
A case of primary cutaneous anaplastic large cell lymphoma with prominent epidermotropism. (22450880)
2012
8
HIV-associated primary cutaneous anaplastic large cell lymphoma: aA clinicopathological subset with more aggressive behavior? Case report and review of the literature. (23061973)
2012
9
Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides. (22776000)
2012
10
Primary cutaneous anaplastic large cell lymphoma arising from a burn scar. (22481116)
2012
11
Syndrome of inappropriate antidiuretic hormone secretion associated with primary cutaneous anaplastic large cell lymphoma. (22409317)
2012
12
Primary cutaneous anaplastic large-cell lymphoma of the eyelid. (21464784)
2012
13
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (21841159)
2011
14
Primary cutaneous anaplastic large cell lymphoma of the nasal tip in a child. (20825571)
2011
15
Primary cutaneous anaplastic large cell lymphoma with leg involvement: a case report and review of 11 cases. (21434982)
2011
16
CD8-positive primary cutaneous anaplastic large cell lymphoma presenting as multiple scrotal nodules and plaques. (21680287)
2011
17
Anaplastic lymphoma kinase expression in a recurrent primary cutaneous anaplastic large cell lymphoma with eventual systemic involvement. (21839333)
2011
18
Perils and pitfalls regarding differential diagnosis and treatment of primary cutaneous anaplastic large-cell lymphoma. (21552770)
2011
19
Primary cutaneous anaplastic large-cell lymphoma. (21163153)
2010
20
Primary cutaneous anaplastic large-cell lymphoma presenting with hemophagocytic syndrome: a case report and review of the literature. (19640585)
2010
21
Pagetoid reticulosis after radiotherapy of primary cutaneous anaplastic large-cell lymphoma. (19940753)
2010
22
Pyogenic variant of primary cutaneous anaplastic large-cell lymphoma: a lymphoproliferative disorder with a predilection for the immunocompromized and the young. (20881832)
2010
23
Primary cutaneous anaplastic large cell lymphoma: a clinicopathologic analysis of 8 cases]. (20079014)
2009
24
Neutrophil/eosinophil-rich type of primary cutaneous anaplastic large cell lymphoma: a clinicopathological, immunophenotypic and molecular study of nine cases. (19694826)
2009
25
CD30-positive primary cutaneous anaplastic large-cell lymphoma and definite squamous cell carcinoma. (19456793)
2009
26
Prognostic factors in primary cutaneous anaplastic large cell lymphoma: characterization of clinical subset with worse outcome. (19528422)
2009
27
MUM1 expression does not differentiate primary cutaneous anaplastic large-cell lymphoma and lymphomatoid papulosis. (19301457)
2009
28
Primary cutaneous anaplastic large cell lymphoma of the vulva: a typical cutaneous lesion with an 'atypical' presenting site. (19707712)
2009
29
Primary cutaneous anaplastic large cell lymphoma arising from lymphomatoid papulosis, responding to low dose methotrexate. (20808598)
2009
30
Differential diagnosis and treatment of primary, cutaneous, anaplastic large cell lymphoma: not always an easy task. (19548068)
2009
31
Primary cutaneous anaplastic large cell lymphoma successfully treated with local thermotherapy using pocket hand warmers. (19120772)
2008
32
MUM1 expression in cutaneous CD30+ lymphoproliferative disorders: a valuable tool for the distinction between lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (18410414)
2008
33
Inhibition of the mammalian target of rapamycin (mTOR) in a case of refractory primary cutaneous anaplastic large cell lymphoma. (18231928)
2008
34
Glatiramer acetate-associated, CD30+, primary, cutaneous, anaplastic large-cell lymphoma. (18852356)
2008
35
Primary cutaneous anaplastic large cell lymphoma of the face presenting as posttraumatic maxillary sinusitis. (19098559)
2008
36
Coexistence of primary cutaneous anaplastic large cell lymphoma and mycosis fungoides in a patient with B-cell chronic lymphocytic leukaemia. (17927791)
2007
37
Successful treatment for recurrence of primary cutaneous anaplastic large-cell lymphoma in elderly patient with etoposide, mitoxantrone, cyclophosphamide, vincristine, prednisolone and bleomycin (VNCOP-B) therapy. (17683387)
2007
38
Primary cutaneous anaplastic large cell lymphoma with fatal leukemic outcome in association with CLA and CCR4-negative conversion. (17938033)
2007
39
Fulminant cutaneous eruption in a 51-year-old man. Primary cutaneous anaplastic large cell lymphoma (C-ALCL). (17310010)
2007
40
Primary cutaneous anaplastic large cell lymphoma associated with vascular endothelial growth factor arising from a burn scar. (17938017)
2007
41
T-cell primary cutaneous anaplastic large cell lymphoma mimicking appearance of large basal cell carcinoma. (16815209)
2006
42
Primary cutaneous anaplastic large cell lymphoma in an elderly patient with cryoglobulinaemic hepatitis C virus infection. (15491453)
2004
43
Evidence for polyclonal infection of Epstein-Barr virus in a patient with primary cutaneous anaplastic large cell lymphoma. (15245536)
2004
44
A case of primary cutaneous anaplastic large cell lymphoma with variant anaplastic lymphoma kinase translocation. (15214912)
2004
45
CD30+ cutaneous lymphoproliferative disorders: the Stanford experience in lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma. (14639383)
2003
46
Co-existent primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis. (14616830)
2003
47
Association of expression of CD44v6 with systemic anaplastic large cell lymphoma: comparison with primary cutaneous anaplastic large cell lymphoma. (11863224)
2002
48
Primary cutaneous anaplastic large cell lymphoma in a young girl. (11730060)
2001
49
Carbamazepine-induced, CD30+, primary, cutaneous, anaplastic large-cell lymphoma. (11346361)
2001
50
Absence of anaplastic lymphoma kinase (ALK) and Epstein-Barr virus gene products in primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis. (9415224)
1997

Variations for Primary Cutaneous Anaplastic Large Cell Lymphoma

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Expression for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Primary Cutaneous Anaplastic Large Cell Lymphoma.

Pathways for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 31KEGG, 52PharmGKB, 54QIAGEN, 5Cell Signaling Technology, 55R&D Systems
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Pathways related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IRF4, STAT5B
2
Show member pathways
9.5IRF4, STAT3
3
Show member pathways
IL-2 Signaling pathway39
9.4STAT5B, STAT3
49.4STAT5B, STAT3
5
Show member pathways
9.4STAT5B, STAT3
6
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)39
9.4STAT5B, STAT3
7
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.4STAT5B, STAT3
8
Show member pathways
9.4STAT5B, STAT3
9
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.4STAT5B, STAT3
10
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.4STAT5B, STAT3
11
Show member pathways
EPO Receptor Signaling39
EPO signaling pathway39
9.4STAT5B, STAT3
129.4STAT5B, STAT3
13
Show member pathways
9.4STAT5B, STAT3
149.4STAT3, STAT5B
159.4STAT3, STAT5B
169.4STAT3, STAT5B
17
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
9.4STAT3, STAT5B
18
Show member pathways
9.4STAT3, STAT5B
199.4STAT3, STAT5B
20
Show member pathways
9.4STAT3, STAT5B
219.4STAT3, STAT5B
229.4STAT3, STAT5B
23
Show member pathways
9.4STAT3, STAT5B
249.4STAT3, STAT5B
259.4STAT3, STAT5B
26
Show member pathways
IL27-mediated signaling events39
9.4STAT3, STAT5B
27
Show member pathways
Development Beta adrenergic receptors regulation of ERK61
G protein signaling G Protein alpha s signaling cascades61
G protein signaling G Protein beta gamma signaling cascades61
9.3CD44, STAT3
289.1STAT3, STAT5B, IRF4
29
Show member pathways
9.0ALK, STAT3, STAT5B
30
Show member pathways
9.0ALK, STAT3, STAT5B
31
Show member pathways
8.9CCR4, STAT3, STAT5B
32
Show member pathways
8.9STAT5B, STAT3, CCR4
338.9STAT5B, STAT3, CCR4
34
Show member pathways
8.5CD44, STAT3, STAT5B, IRF4
35
Show member pathways
8.5ALK, CCR4, STAT3, STAT5B
36
Show member pathways
8.5STAT5B, STAT3, CCR4, ALK
37
Show member pathways
8.5STAT5B, STAT3, CCR4, ALK

Compounds for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience
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Compounds related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1dasatinib46 52 1211.6STAT5B, STAT3
2gp 130469.4STAT3, STAT5B
3phosphotyrosine469.2STAT5B, STAT3, ALK
4[alcl]469.2ALK, CCR4, STAT3
5ly294002469.0CD44, STAT3, STAT5B
6rantes469.0CD44, CCR4, STAT3
7doxorubicin46 52 1210.9STAT3, ALK, CD44
8cycloheximide468.9CD44, STAT3, STAT5B
9phosphatidylinositol468.7STAT5B, STAT3, ALK, CD44
10alanine468.7STAT5B, STAT3, ALK, CD44
11paraffin468.6CD44, ALK, CCR4, STAT3
12retinoic acid46 259.6CD44, CCR4, STAT3, STAT5B
13serine468.4STAT5B, STAT3, ALK, CD44
14tyrosine468.2STAT5B, STAT3, CCR4, ALK, CD44
15testosterone46 62 25 1211.2TRG, CD44, STAT3

GO Terms for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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17Gene Ontology
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Biological processes related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-2 biosynthetic processGO:0450869.9STAT5B, IRF4
2JAK-STAT cascade involved in growth hormone signaling pathwayGO:0603979.6STAT5B, STAT3
3regulation of multicellular organism growthGO:0400149.6STAT5B, STAT3
4phosphorylationGO:0163109.6ALK, STAT3
5JAK-STAT cascadeGO:0072599.6STAT5B, STAT3
6cellular response to hormone stimulusGO:0328709.5STAT3, STAT5B
7interferon-gamma-mediated signaling pathwayGO:0603339.5IRF4, CD44
8acute-phase responseGO:0069539.4STAT3, STAT5B
9response to ethanolGO:0454719.4STAT3, STAT5B
10cytokine-mediated signaling pathwayGO:0192219.2CD44, STAT3, IRF4
11response to estradiolGO:0323559.1STAT3, STAT5B

Molecular functions related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.4STAT3, STAT5B
2glucocorticoid receptor bindingGO:0352599.1STAT3, STAT5B

Products for genes affiliated with Primary Cutaneous Anaplastic Large Cell Lymphoma

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Sources for Primary Cutaneous Anaplastic Large Cell Lymphoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet