MCID: PRM155
MIFTS: 36

Primary Cutaneous Anaplastic Large Cell Lymphoma

Categories: Skin diseases, Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Primary Cutaneous Anaplastic Large Cell Lymphoma

MalaCards integrated aliases for Primary Cutaneous Anaplastic Large Cell Lymphoma:

Name: Primary Cutaneous Anaplastic Large Cell Lymphoma 56
Lymphoma, Primary Cutaneous Anaplastic Large Cell 69
Regressive Atypical Histiocytosis 56
Primary C-Alcl 56

Characteristics:

Orphanet epidemiological data:

56
primary cutaneous anaplastic large cell lymphoma
Age of onset: Adolescent,Adult,Childhood; Age of death: adult;

Classifications:



External Ids:

Orphanet 56 ORPHA300865
UMLS via Orphanet 70 C1301362 C1698767
ICD10 via Orphanet 34 C86.6

Summaries for Primary Cutaneous Anaplastic Large Cell Lymphoma

MalaCards based summary : Primary Cutaneous Anaplastic Large Cell Lymphoma, also known as lymphoma, primary cutaneous anaplastic large cell, is related to anaplastic large cell lymphoma and lymphoma. An important gene associated with Primary Cutaneous Anaplastic Large Cell Lymphoma is NPM1 (Nucleophosmin), and among its related pathways/superpathways are NF-kappaB Signaling and Tyrosine Kinases / Adaptors. The drugs Bexarotene and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone, and related phenotype is neoplasm.

Related Diseases for Primary Cutaneous Anaplastic Large Cell Lymphoma

Diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Related Disease Score Top Affiliating Genes
1 anaplastic large cell lymphoma 10.8
2 lymphoma 10.8
3 chronic intestinal vascular insufficiency 10.5 ALK PTPRC
4 plummer vinson syndrome 10.4 MUC1 PTPRC
5 short-rib thoracic dysplasia 12 10.4 MUC1 PTPRC
6 epicardium cancer 10.4 ALK MUC1
7 ovarian mucinous adenocarcinoma 10.4 MUC1 PTPRC
8 spondyloepimetaphyseal dysplasia, isidor type 10.4 MUC1 PTPRC
9 cribriform carcinoma 10.4 MUC1 PTPRC
10 cecum adenocarcinoma 10.3 ALK MUC1
11 dense deposit disease 10.3 MUC1 PTPRC
12 lymphomatoid papulosis 10.3
13 hypoglycemia 10.3 GZMB TIA1
14 male infertility 10.3 GZMB TIA1
15 clivus chondroid chordoma 10.3 GZMB TIA1
16 rubella panencephalitis 10.3 GZMB TIA1
17 gastrointestinal tuberculosis 10.3 GZMB TIA1
18 breast fibroadenosis 10.2 GZMB TIA1
19 pediatric lymphoma 10.2 GZMB TIA1
20 testicular germ cell cancer 10.2 GZMB TIA1
21 cerebrum cancer 10.2 MUC1 PTPRC
22 renal hypertension 10.2 GZMB TIA1
23 penile disease 10.2 ALK IRF4 PTPRC
24 mucinous intrahepatic cholangiocarcinoma 10.2 GZMB TIA1
25 mycosis fungoides 10.2
26 plasmodium ovale malaria 10.2 GZMB TIA1
27 dextrocardia with situs inversus 10.1 MUC1 PTPRC
28 mixed cell type cancer 10.1 GZMB TIA1
29 serous cystadenocarcinoma 10.1 MUC1 PTPRC
30 immunodeficiency 11a 10.0 GZMB TIA1
31 human herpesvirus 8 10.0
32 burn scar 10.0
33 burns 10.0
34 squamous cell carcinoma 10.0
35 pneumonia 10.0
36 polycystic ovary syndrome 10.0 ALK GZMB TIA1
37 histiocytosis 9.9
38 hepatitis c virus 9.9
39 hemophagocytic lymphohistiocytosis 9.9
40 hepatitis 9.9
41 leukemia 9.9
42 lymphedema 9.9
43 sinusitis 9.9
44 keratosis 9.9
45 hepatitis c 9.9
46 maxillary sinusitis 9.9
47 basal cell carcinoma 9.9
48 dermatitis 9.9
49 atopic dermatitis 9.9
50 cerebritis 9.9

Graphical network of the top 20 diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma:



Diseases related to Primary Cutaneous Anaplastic Large Cell Lymphoma

Symptoms & Phenotypes for Primary Cutaneous Anaplastic Large Cell Lymphoma

MGI Mouse Phenotypes related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 ALK IRF4 NPM1 PTPRC

Drugs & Therapeutics for Primary Cutaneous Anaplastic Large Cell Lymphoma

Drugs for Primary Cutaneous Anaplastic Large Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bexarotene Approved, Investigational Phase 3,Phase 1 153559-49-0 82146
2
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
3
leucovorin Approved, Nutraceutical Phase 3,Phase 1 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1 59-30-3 6037
5 Folic Acid Antagonists Phase 3,Phase 1
6 Vitamin B Complex Phase 3,Phase 1
7 Immunosuppressive Agents Phase 3,Phase 1
8 Protective Agents Phase 3,Phase 1
9 Immunoglobulins Phase 3,Phase 2
10 Antibodies, Monoclonal Phase 3,Phase 2
11 Antibodies Phase 3,Phase 2
12 Dermatologic Agents Phase 3
13 Nucleic Acid Synthesis Inhibitors Phase 3
14 Antimetabolites Phase 3
15 Antimetabolites, Antineoplastic Phase 3
16 Antirheumatic Agents Phase 3
17 Folate Nutraceutical Phase 3,Phase 1
18 Vitamin B9 Nutraceutical Phase 3,Phase 1
19
nivolumab Approved Phase 2 946414-94-4
20
Sorafenib Approved, Investigational Phase 1 284461-73-0 216239 406563
21
Lenalidomide Approved Phase 1 191732-72-6 216326
22
Hydroxocobalamin Approved Phase 1 13422-51-0 11953898 5460373 44475014
23
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
24
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
25
Nicotinamide Approved, Nutraceutical Phase 1 98-92-0 936
26
Cyanocobalamin Approved, Nutraceutical Phase 1 68-19-9 44176380
27 10-deazaaminopterin Phase 1
28 Micronutrients Phase 1
29 Hematinics Phase 1
30 Nicotinic Acids Phase 1
31 Trace Elements Phase 1
32 Angiogenesis Inhibitors Phase 1
33 Angiogenesis Modulating Agents Phase 1
34 Vitamin B 12 Phase 1
35 Anti-Bacterial Agents Phase 1
36 Vitamins Phase 1
37 Anti-Infective Agents Phase 1
38 Protein Kinase Inhibitors Phase 1
39 Histone Deacetylase Inhibitors Phase 1
40 Vitamin B12 Nutraceutical Phase 1
41
Cobalamin Nutraceutical Phase 1 13408-78-1 6438156
42
Methylcobalamin Experimental, Nutraceutical Phase 1 13422-55-4
43 Vitamin B3 Nutraceutical Phase 1
44
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
45
Cholecalciferol Approved, Nutraceutical 67-97-0 6221 10883523 5280795
46
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
47 Trientine
48 Ergocalciferols
49 Bone Density Conservation Agents
50 Vitamin D2 Nutraceutical

Interventional clinical trials:

(show all 13)

id Name Status NCT ID Phase Drugs
1 A Phase 3 Trial of Brentuximab Vedotin(SGN-35) Versus Physician's Choice (Methotrexate or Bexarotene) in Patients With CD30-Positive Cutaneous T-Cell Lymphoma Active, not recruiting NCT01578499 Phase 3 Brentuximab Vedotin;Methotrexate or Bexarotene
2 Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma Completed NCT00099255 Phase 2 SGN-30
3 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2
4 SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP) Active, not recruiting NCT01352520 Phase 2 SGN-35
5 MDX-060 in Patients With Relapsed or Refractory Classic Systemic or Primary Cutaneous Anaplastic Large Cell Lymphoma Withdrawn NCT00298467 Phase 2 MDX-060
6 Multicentre Phase I Trial of Engineered T Cells for Patients With Relapsed or Refractory Primary Cutaneous CD30+ Large T Cell Lymphoma or Transformed CD30+ Mycosis Fungoides Unknown status NCT01645293 Phase 1
7 Pralatrexate and Bexarotene in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma Completed NCT01134341 Phase 1 Pralatrexate Injection;Bexarotene Capsules
8 Study of Pralatrexate in Patients With Relapsed or Refractory Cutaneous T-cell Lymphoma Completed NCT00554827 Phase 1 Pralatrexate Injection
9 Lenalidomide After Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancers Completed NCT01254578 Phase 1 Lenalidomide
10 A Pilot Study of Sorafenib Examining Biomarkers in Refractory or Relapsed T-Cell Lymphoma Patients Completed NCT01561833 Phase 1 Sorafenib
11 Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma Active, not recruiting NCT01567709 Phase 1 Alisertib;Vorinostat
12 Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma Recruiting NCT02652715
13 Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency Recruiting NCT01787409

Search NIH Clinical Center for Primary Cutaneous Anaplastic Large Cell Lymphoma

Genetic Tests for Primary Cutaneous Anaplastic Large Cell Lymphoma

Anatomical Context for Primary Cutaneous Anaplastic Large Cell Lymphoma

MalaCards organs/tissues related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

39
T Cells, Skin, Bone, B Cells, Bone Marrow, Neutrophil, Myeloid

Publications for Primary Cutaneous Anaplastic Large Cell Lymphoma

Articles related to Primary Cutaneous Anaplastic Large Cell Lymphoma:

(show top 50) (show all 94)
id Title Authors Year
1
Primary cutaneous anaplastic large cell lymphoma with intralymphatic involvement associated with chronic lymphedema. ( 28337783 )
2017
2
Outcome of primary cutaneous anaplastic large cell lymphoma: a 20-year British Columbia Cancer Agency experience. ( 27766622 )
2017
3
Disseminated CD8-positive, CD30-positive cutaneous lymphoproliferative eruption with overlapping features of mycosis fungoides and primary cutaneous anaplastic large cell lymphoma following remote solitary lesional presentation. ( 28497585 )
2017
4
Myxoid variant of primary cutaneous anaplastic large cell lymphoma: First 2 cases. ( 28626950 )
2017
5
Primary cutaneous anaplastic large cell lymphoma. ( 28342276 )
2017
6
KIR3DL2 (CD158k) is a potential therapeutic target in primary cutaneous anaplastic large cell lymphoma. ( 27037558 )
2016
7
Low-dose radiotherapy for primary cutaneous anaplastic large-cell lymphoma while on low-dose methotrexate. ( 27874877 )
2016
8
Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection. ( 27382410 )
2016
9
A case of CD4(+)/CD8(+) double-positive primary cutaneous anaplastic large cell lymphoma of the lip involving spontaneous regression after biopsy. ( 27694065 )
2016
10
Primary cutaneous anaplastic large cell lymphoma in a child simulating primary cutaneous Hodgkin's disease. ( 26728828 )
2016
11
Synchronous Occurrence of Primary Cutaneous Anaplastic Large Cell Lymphoma and Squamous Cell Carcinoma. ( 27489433 )
2016
12
Multiple cytokine-producing primary cutaneous anaplastic large cell lymphoma. ( 27256346 )
2016
13
Radiation Therapy for Primary Cutaneous Anaplastic Large Cell Lymphoma: An International Lymphoma Radiation Oncology Group Multi-institutional Experience. ( 27315663 )
2016
14
Primary Cutaneous Anaplastic Large-Cell Lymphoma With 6p25.3 Rearrangement in a Cardiac Transplant Recipient: A Case Report and Review of the Literature. ( 26863058 )
2016
15
Primary cutaneous anaplastic large cell lymphoma masquerading as large pyogenic granuloma. ( 27990392 )
2016
16
Primary cutaneous anaplastic large-cell lymphoma: a case report. ( 26970422 )
2016
17
Occult Dermal Lymphatic Involvement Is Frequent in Primary Cutaneous Anaplastic Large Cell Lymphoma. ( 26381026 )
2015
18
A rare case of ALK negative CD30+ primary cutaneous anaplastic large cell lymphoma in a young adult. ( 26458652 )
2015
19
Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule. ( 25633507 )
2015
20
Primary cutaneous anaplastic large cell lymphoma in a child simulating primary cutaneous Hodgkin's disease. ( 26658398 )
2015
21
Treatment of primary cutaneous anaplastic large cell lymphoma with superficial x-rays. ( 25918620 )
2015
22
Primary cutaneous anaplastic large cell lymphoma in a patient receiving adalimumab. ( 27051683 )
2015
23
Efficacy of Vinblastine in Primary Cutaneous Anaplastic Large Cell Lymphoma. ( 26108120 )
2015
24
Assessment of diagnostic criteria between primary cutaneous anaplastic large cell lymphoma and CD30-rich transformed mycosis fungoides. A study of 66 cases. ( 25645336 )
2015
25
Composite Mantle Cell and Primary Cutaneous Anaplastic Large Cell Lymphoma: Case Report and Review of the Literature. ( 25374307 )
2014
26
Comparison of CD163+ Macrophages and CD206+ Cells in Lesional Skin of CD30+ Lymphoproliferative Disorders of Lymphomatoid Papulosis and Primary Cutaneous Anaplastic Large-cell Lymphoma. ( 25403560 )
2014
27
Hemophagocytic lymphohistiocytosis in association with primary cutaneous anaplastic large cell lymphoma. ( 25405042 )
2014
28
Congenital Primary Cutaneous Anaplastic Large-Cell Lymphoma: A Case Report. ( 25365497 )
2014
29
Keratosis lichenoides chronica in association with primary cutaneous anaplastic large cell lymphoma. ( 23228152 )
2014
30
Chronic Reparative Changes in Medium-Sized Vessels in a Case of Primary Cutaneous Anaplastic Large-Cell Lymphoma With Angioinvasive Features and Cytotoxic Phenotype: New Histopathological Findings in Line With Indolent Clinical Behavior. ( 25365499 )
2014
31
Primary cutaneous anaplastic large cell lymphoma occurring in an atopic dermatitis patient: a case report with review of the literature with emphasis on their association. ( 24817972 )
2014
32
Remission of primary cutaneous anaplastic large cell lymphoma after a brief course of brentuximab vedotin. ( 23086510 )
2013
33
Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report. ( 24099147 )
2013
34
Primary cutaneous anaplastic large-cell lymphoma - case report. ( 24346900 )
2013
35
Primary cutaneous anaplastic large cell lymphoma simulating an aggressive angiocentric T-cell lymphoma. ( 22458926 )
2013
36
Primary Cutaneous Anaplastic Large Cell Lymphoma with Angioinvasive Features and Cytotoxic Phenotype: A Rare Lymphoma Variant within the Spectrum of CD30+ Lymphoproliferative Disorders. ( 24246691 )
2013
37
Primary cutaneous anaplastic large-cell lymphoma. ( 21552098 )
2013
38
Successful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Intralesional Methotrexate Therapy. ( 24002114 )
2013
39
Granulocyte-colony stimulating factor-producing primary cutaneous anaplastic large cell lymphoma with cerebral metastasis. ( 22565644 )
2013
40
Syndrome of inappropriate antidiuretic hormone secretion associated with primary cutaneous anaplastic large cell lymphoma. ( 22409317 )
2012
41
Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides. ( 22776000 )
2012
42
Primary cutaneous anaplastic large-cell lymphoma occurring in a case of chronic myeloid leukemia in remission. ( 22775801 )
2012
43
A case of primary cutaneous anaplastic large cell lymphoma with prominent epidermotropism. ( 22450880 )
2012
44
Primary cutaneous anaplastic large-cell lymphoma of the eyelid. ( 21464784 )
2012
45
HIV-associated primary cutaneous anaplastic large cell lymphoma: aA clinicopathological subset with more aggressive behavior? Case report and review of the literature. ( 23061973 )
2012
46
Anaplastic lymphoma kinase-positive primary cutaneous anaplastic large cell lymphoma--is it a new variant? ( 22565437 )
2012
47
Imprint cytology facilitating the diagnosis of primary cutaneous anaplastic large cell lymphoma of iliac fossa. ( 23326035 )
2012
48
Primary cutaneous anaplastic large cell lymphoma arising from a burn scar. ( 22481116 )
2012
49
Anaplastic lymphoma kinase expression in a recurrent primary cutaneous anaplastic large cell lymphoma with eventual systemic involvement. ( 21839333 )
2011
50
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. ( 21841159 )
2011

Variations for Primary Cutaneous Anaplastic Large Cell Lymphoma

Expression for Primary Cutaneous Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Primary Cutaneous Anaplastic Large Cell Lymphoma.

Pathways for Primary Cutaneous Anaplastic Large Cell Lymphoma

Pathways related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.75 GZMB IRF4 PTPRC TYK2
2 11.59 ALK NPM1 TYK2
3 11.39 IRF4 MUC1 TYK2
4 11.17 PTPRC TYK2
5 11.02 PTPRC TYK2
6 10.91 TIA1 TYK2
7
Show member pathways
10.78 IRF4 TYK2
8 10.7 GZMB IRF4 PTPRC

GO Terms for Primary Cutaneous Anaplastic Large Cell Lymphoma

Biological processes related to Primary Cutaneous Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 type I interferon signaling pathway GO:0060337 9.16 IRF4 TYK2
2 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 8.96 MUC1 NPM1
3 positive regulation of protein kinase activity GO:0045860 8.32 PTPRC

Sources for Primary Cutaneous Anaplastic Large Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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