PEL
MCID: PRM042
MIFTS: 45

Primary Effusion Lymphoma (PEL) malady

Blood diseases, Cancer diseases, Infectious diseases, Immune diseases categories

Summaries for Primary Effusion Lymphoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Primary effusion lymphoma (PEL) is a B-cell lymphoma. more...

MalaCards: Primary Effusion Lymphoma, also known as PEL, is related to sarcoma and hepatitis c, and has symptoms including peritonitis/peritoneal abscess, lymphoma and abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax. An important gene associated with Primary Effusion Lymphoma is CD2 (CD2 molecule), and among its related pathways are Cell surface interactions at the vascular wall and TRAF Pathway. The compounds doxorubicin and serine have been mentioned in the context of this disorder. Affiliated tissues include b cells and lung, and related mouse phenotypes are reproductive system and hematopoietic system.

Aliases & Classifications for Primary Effusion Lymphoma

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 44Novoseek, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Infectious diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
primary effusion lymphoma:
Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

primary effusion lymphoma 42 48 60
pel 42 48
body cavity-based lymphoma 48
lymphoma, aids-related 60
aids-related lymphoma 42
lymphoma aids-related 44


External Ids:

MESH via Orphanet35 D054685
ICD10 via Orphanet26 C83.8
SNOMED-CT via Orphanet57 128800006
UMLS via Orphanet61 C1292753

Related Diseases for Primary Effusion Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Primary Effusion Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.4TNFRSF10B
2hepatitis c30.8CD58, MYB, IRF3
3hepatitis b30.3CD58, MYB
4burkitt's lymphoma30.3BCL6, TCL1A
5multiple myeloma30.1SDC1, XBP1
6multiple sclerosis30.1SELPLG, CD2, CD58
7central nervous system lymphoma30.1BCL6
8myeloma30.1TNFRSF10B, POU2F2, CD58, XBP1, TCL1A, BCL6
9hepatocellular carcinoma30.1XBP1, CDKN1B, CD58, TNFRSF10B, SKP2
10lymphoma aidsrelated30.1TCL1A, BCL6
11hodgkin's lymphoma30.1POU2AF1, POU2F2, TCL1A, BCL6
12kaposi's sarcoma10.9
13hepatitis10.6
14liver lymphoma10.5
15hepatitis a10.5
16liver cirrhosis10.4
17pericardial effusion10.4
18peritonitis10.4
19heart lymphoma10.2
20diffuse large b-cell lymphoma10.2
21acquired immunodeficiency syndrome10.2
22primary pulmonary hypertension10.1
23cardiac tamponade10.1
24colon lymphoma10.1
25richter's syndrome10.1
26epstein-barr virus hepatitis10.1
27common variable immunodeficiency10.1
28autoimmune hemolytic anemia10.1
29polycystic kidney disease10.1
30anaplastic large cell lymphoma10.1
31constrictive pericarditis10.1
32hemolytic anemia10.1
33hypertension10.1
34kidney disease10.1
35mediastinitis10.1
36pericarditis10.1
37severe combined immunodeficiency10.1
38pancytopenia10.0
39pelger-huet anomaly10.0
40myeloid leukemia10.0MYB, TNFRSF10B
41acute leukemia10.0MYB, CD58, CD7
42cervical cancer10.0SKP2, CDKN1B, TNFRSF10B
43lymphedema10.0LYVE1
44arthritis10.0CD58, TNFRSF10B
45adenoma10.0TNFRSF10B, VEGFB, CDKN1B, SKP2
46b-cell chronic lymphocytic leukemia10.0TNFRSF10B, CDKN1B, TCL1A, BCL6
47adenocarcinoma10.0SKP2, CDKN1B, MYB, TNFRSF10B
48follicular lymphoma10.0MYB, CDKN1B, SKP2, TCL1A, BCL6
49chronic lymphocytic leukemia10.0MYB, CD58, TCL1A, BCL6
50rheumatoid arthritis10.0TNFRSF10B, IRF3, MYB, CD58, CD7

Graphical network of the top 20 diseases related to Primary Effusion Lymphoma:



Diseases related to primary effusion lymphoma

Clinical Features for Primary Effusion Lymphoma

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48Orphanet
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Symptoms:

48 (show all 8)
  • peritonitis/peritoneal abscess
  • lymphoma
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • acute abdominal pain/colic
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • early death/lethality
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction

Drugs & Therapeutics for Primary Effusion Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Primary Effusion Lymphoma

Drug clinical trials:

Search ClinicalTrials for Primary Effusion Lymphoma

Search NIH Clinical Center for Primary Effusion Lymphoma

Search CenterWatch for Primary Effusion Lymphoma

Genetic Tests for Primary Effusion Lymphoma

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Anatomical Context for Primary Effusion Lymphoma

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32MalaCards
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MalaCards organs/tissues related to Primary Effusion Lymphoma:

32
B cells, Lung

Animal Models for Primary Effusion Lymphoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Primary Effusion Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.3TCL1A, SKP2, CDKN1B, VEGFB
2MP:00053979.9CORO1A, CASP2, TNFRSF10B, POU2AF1, POU2F2, MYB
3MP:00053879.9SDC1, CORO1A, CASP2, TNFRSF10B, IRF3, POU2AF1
4MP:00107689.9CASP2, TNFRSF10B, VEGFB, POU2AF1, POU2F2, MYB
5MP:00053849.9POU2F2, POU2AF1, IRF3, TNFRSF10B, CASP2, CORO1A
6MP:00053769.7POU2F2, VEGFB, IRF3, TNFRSF10B, CDKN1B, XBP1

Publications for Primary Effusion Lymphoma

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Genetic Variations for Primary Effusion Lymphoma

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Expression for genes affiliated with Primary Effusion Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Effusion Lymphoma

Search GEO for disease gene expression data for Primary Effusion Lymphoma.

Pathways for genes affiliated with Primary Effusion Lymphoma

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Sources:
53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Primary Effusion Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Primary Effusion Lymphoma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1doxorubicin44 49 1112.5CASP2, TNFRSF10B, MYB, CD58, CDKN1B, BCL6
2serine4410.5CASP2, TNFRSF10B, POU2F2, CDKN1B, TCL1A, SELPLG
3flavopiridol44 1111.5CDKN1B, TNFRSF10B, CASP2
4estrogen4410.5BCL6
5paraffin4410.5CASP2, CDKN1B, SKP2, BCL6, LYVE1
6thymidine44 2411.5TNFRSF10B, MYB, CD2, CDKN1B, LYVE1
7threonine4410.5CASP2, TNFRSF10B, IRF3, MYB, CDKN1B, TCL1A
8butyrate4410.4MYB
9vegf4410.4TNFRSF10B, VEGFB, MYB, CDKN1B, XBP1, LYVE1
10oligonucleotide4410.4CASP2, POU2F2, MYB, CDKN1B, SKP2, LYVE1
11lipid4410.4CASP2, TNFRSF10B, IRF3, MYB, CD58, CD2
12retinoic acid44 2411.4BCL6, CASP2, TNFRSF10B, IRF3, MYB, CD58
13oxygen44 2411.4CASP2, TNFRSF10B, VEGFB, MYB, CDKN1B, SELPLG
14wortmannin4410.3CDKN1B, CD2, TNFRSF10B, CASP2
15tyrosine4410.3IRF3, VEGFB, POU2AF1, POU2F2, MYB, CD2
16alefacept44 1111.3CD2, CD58
17steroid449.9CASP2, IRF3, POU2F2, MYB, LYVE1

GO Terms for genes affiliated with Primary Effusion Lymphoma

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16Gene Ontology
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Biological processes related to Primary Effusion Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription from RNA polymerase II promoterGO:00636610.3XBP1, POU2F2, POU2AF1, IRF3
2blood coagulationGO:00759610.2SELPLG, CD2, CD58, MYB, VEGFB
3leukocyte migrationGO:05090010.1CD58, CD2, SELPLG

Molecular functions related to Primary Effusion Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:00487210.3LYVE1, CD7, CD2, TNFRSF10B
2protein bindingGO:0055159.5SDC1, CORO1A, CASP2, TNFRSF10B, IRF3, VEGFB

Products for genes affiliated with Primary Effusion Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Primary Effusion Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet