MCID: PRM010
MIFTS: 51

Primary Open Angle Glaucoma malady

Summaries for Primary Open Angle Glaucoma

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46OMIM, 32MalaCards
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MalaCards: Primary Open Angle Glaucoma, also known as primary open-angle glaucoma, is related to glaucoma and open-angle glaucoma. An important gene associated with Primary Open Angle Glaucoma is WDR36 (WD repeat domain 36), and among its related pathways are Elastic fibre formation and Estrogen metabolism. The compounds vitamin a and valine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotype vision/eye.

Description from OMIM:46 137760

Aliases & Classifications for Primary Open Angle Glaucoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 20GeneTests, 22GTR, 56SNOMED-CT, 39NCIt, 46OMIM, 27ICD9CM
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Aliases & Descriptions:

primary open angle glaucoma 8 10 44 30 60
primary open-angle glaucoma 8 20 22
chronic simple glaucoma 8


External Ids:

Disease Ontology8 DOID:1070
NCIt39 C35394
SNOMED-CT56 155122001, 77075001
OMIM46 137760
ICD9CM27 365.11

Related Diseases for Primary Open Angle Glaucoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Glaucoma 1a, Primary Open Angle family:

primary open angle glaucoma Open-Angle Glaucoma
Primary Open Angle Glaucoma Juvenile Onset 1 Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma 1b, Primary Open Angle, Adult Onset Glaucoma 1c, Primary Open Angle
Glaucoma 1d, Primary Open Angle Glaucoma, Primary Open Angle, Juvenile-Onset, 2
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, 1o Glaucoma 1k, Primary Open Angle, Juvenile-Onset

Diseases related to Primary Open Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma32.5TGFB2, ELN, CYP1B1, MYOC, NTF4, WDR36
2open-angle glaucoma32.5LOXL1, TGFB2, ELN, GSTM1, CYP1B1, MYOC
3ocular hypertension31.7OPTN, MYOC
4primary angle-closure glaucoma31.4MYOC
5retinitis31.3RHO
6cataract31.0RHO, MYOC, TGFB2
7exfoliation syndrome30.9ELN, LOXL1
8primary congenital glaucoma30.7CYP1B1
9primary open angle glaucoma juvenile onset 130.7MYOC, CYP1B1
10age related macular degeneration30.4RHO
11hypertension11.2
12juvenile glaucoma10.9
13myopia10.7
14low tension glaucoma10.6
15glaucoma 1, open angle, e10.5
16choroiditis10.4
17glaucomatocyclitic crisis10.4
18kearns-sayre syndrome10.4
19neuropathy10.4
20retinal vein occlusion10.4
21senile cataract10.4
22steroid-induced glaucoma - borderline10.3
23neovascular glaucoma10.3
24cycloplegia10.3
25cerebritis10.3
26exudative vitreoretinopathy10.3
27central retinal vein occlusion10.3
28alzheimer's disease10.3
29degenerative myopia10.3
30astigmatism10.3
31dementia10.3
32intracranial hypertension10.3
33keratoconus10.3
34migraine10.3
35mitochondrial encephalomyopathy10.3
36ocular hypotension10.3
37pancreatitis10.3
38pneumonia10.3
39refractive error10.3
40steroid-induced glaucoma10.3
41congenital stromal corneal dystrophy10.3
42glaucoma 1a, primary open angle10.3
43glaucoma 1c, primary open angle10.3
44glaucoma 1d, primary open angle10.3
45iridocyclitis10.1
46eye disease10.0OPTN, RHO, MYOC, ABCA4, TGFB2
47glaucoma 3, primary congenital, d10.0CYP1B1, MYOC, OPTN
48optic nerve disease10.0OPTN, MYOC, ELN
49blindness10.0OPTN, RHO, WDR36, MYOC, ABCA4
50peters plus syndrome10.0CYP1B1

Graphical network of the top 20 diseases related to Primary Open Angle Glaucoma:



Diseases related to primary open angle glaucoma

Clinical Features for Primary Open Angle Glaucoma

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Sources:
46OMIM
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Clinical features from OMIM:

137760

Drugs & Therapeutics for Primary Open Angle Glaucoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Primary Open Angle Glaucoma

Drug clinical trials:

Search ClinicalTrials for Primary Open Angle Glaucoma

Search NIH Clinical Center for Primary Open Angle Glaucoma

Search CenterWatch for Primary Open Angle Glaucoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Primary Open Angle Glaucoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Primary Open Angle Glaucoma:
Renexus
Embryonic/Adult Cultured Cells Related to Primary Open Angle Glaucoma:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Primary Open Angle Glaucoma

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20GeneTests, 22GTR
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Genetic tests related to Primary Open Angle Glaucoma:

id Genetic test Affiliating Genes
1 Primary Open Angle Glaucoma (adult Onset)20 22 WDR36
2 Primary Open Angle Glaucoma22

Anatomical Context for Primary Open Angle Glaucoma

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32MalaCards
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MalaCards organs/tissues related to Primary Open Angle Glaucoma:

32
Eye, Testes, Endothelial, Brain, Retina, Cortex

Animal Models for Primary Open Angle Glaucoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Primary Open Angle Glaucoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.6TGFB2, ABCA4, CYP1B1, MYOC, RHO, ATOH7

Publications for Primary Open Angle Glaucoma

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50PubMed
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Articles related to Primary Open Angle Glaucoma:

(show top 50)    (show all 745)
idTitleAuthorsYear
1
Ocular blood flow velocity in primary open angle glaucoma--a tropical African population study. (23741138)
2013
2
Health- and vision-related quality of life in patients with ocular hypertension or primary open-angle glaucoma. (23614930)
2013
3
Polymorphisms in matrix metalloproteinases MMP1 and MMP9 are associated with primary open-angle and angle closure glaucoma in a Pakistani population. (23441116)
2013
4
Association transient receptor potential melastatin channel gene polymorphism with primary open angle glaucoma. (24019741)
2013
5
Contribution of the latent transforming growth factor-I^ binding protein 2 gene to etiology of primary open angle glaucoma and pseudoexfoliation syndrome. (23401661)
2013
6
Dynamic contour tonometry in primary open angle glaucoma and pseudoexfoliation glaucoma: factors associated with intraocular pressure and ocular pulse amplitude. (23741135)
2013
7
Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. (22561696)
2012
8
Effect of topical Beta blocker (Timolol maleate 0.5%) in primary open angle glaucoma. (23134912)
2012
9
A tertiary level hospital-based study on frequency of changing presbyopic glasses in primary open angle glaucoma patients. (23025223)
2012
10
A double-masked randomized crossover study comparing the effect of latanoprost/timolol and brimonidine/timolol fixed combination on intraocular pressure and ocular blood flow in patients with primary open-angle glaucoma or ocular hypertension. (22775229)
2012
11
Influence of rheological factors on the development of primary open angle glaucoma. (23346803)
2012
12
Endothelin-1 plasma levels and vascular endothelial dysfunction in primary open angle glaucoma. (22406080)
2012
13
Evaluation of NTF4 as a causative gene for primary open-angle glaucoma. (22815630)
2012
14
Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a meta-analysis. (22902176)
2012
15
Peak intraocular pressure and glaucomatous progression in primary open-angle glaucoma. (22004074)
2012
16
Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma. (22328638)
2012
17
Comparing the efficacy of the monocular trial treatment paradigm with multiple measurements of intraocular pressure before and after treatment initiation in primary open-angle glaucoma. (22536042)
2012
18
Pneumotrabeculoplasty as treatment for primary open angle glaucoma: critical review of the literature. (23099973)
2012
19
Alzheimer's disease and primary open-angle glaucoma: is there a connection? (21760717)
2011
20
Helicobacter pylori infection as a risk factor for both primary open-angle glaucoma and pseudoexfoliative glaucoma in Thessaloniki Eye Study. (22107938)
2011
21
Patterns of damage in chronic angle-closure glaucoma compared to primary open-angle glaucoma. (21470591)
2011
22
Effect of caffeine on the intraocular pressure in patients with primary open angle glaucoma. (22140308)
2011
23
Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. (21379321)
2011
24
WDR36 variants in East Indian primary open-angle glaucoma patients. (22025897)
2011
25
Mitochondrial damage in the trabecular meshwork occurs only in primary open-angle glaucoma and in pseudoexfoliative glaucoma. (21283745)
2011
26
Functional MRI signal changes in primary visual cortex corresponding to the central normal visual field of patients with primary open-angle glaucoma. (20357191)
2010
27
Potential diagnostic value of fluorescein angiography and color Doppler imaging in primary open-angle glaucoma. (20954150)
2010
28
Anthropometric measures and their relation to incident primary open-angle glaucoma. (20382429)
2010
29
Association of IL1A and IL1B loci with primary open angle glaucoma. (20565898)
2010
30
Fluorescein leakage of the optic disc: time course in primary open-angle glaucoma. (20444140)
2010
31
Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma. (19662433)
2009
32
The genetics of primary open-angle glaucoma: a review. (19061886)
2009
33
Lack of association between optineurin gene variants T34T, E50K, M98K, 691_692insAG and R545Q and primary open angle glaucoma in Brazilian patients. (19172505)
2009
34
Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. (19765683)
2009
35
Comparison of twice-daily and three-times-daily dosing of dorzolamide in ocular hypertension and primary open-angle glaucoma patients treated with latanoprost. (18369537)
2008
36
Efficacy and safety of latanoprost versus pilocarpine/timolol maleate fixed combination in patients with primary open-angle glaucoma or ocular hypertension. (18721251)
2008
37
Cost-effectiveness of early detection and treatment of ocular hypertension and primary open-angle glaucoma by the ophthalmologist. (17128205)
2008
38
Conjunctival modifications in ocular hypertension and primary open angle glaucoma: an in vivo confocal microscopy study. (18316705)
2008
39
Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change. (17359525)
2007
40
Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients. (17563717)
2007
41
The efficacy and safety of timolol maleate versus brinzolamide each given twice daily added to travoprost in patients with ocular hypertension or primary open-angle glaucoma. (17191187)
2006
42
Mitochondrial abnormalities in patients with primary open-angle glaucoma. (16723467)
2006
43
Associations between the deletion polymorphism of the angiotensin 1-converting enzyme gene and ocular signs of primary open-angle glaucoma. (15864617)
2005
44
Identification of flotillin-1 as a protein interacting with myocilin: implications for the pathogenesis of primary open-angle glaucoma. (16198165)
2005
45
From gene to disease; primary open-angle glaucoma and three known genes: MYOC, CYP1B1 and OPTN]. (15283026)
2004
46
Mutations in the optineurin gene in Japanese patients with primary open-angle glaucoma and normal tension glaucoma. (14755458)
2004
47
A review of genetic and structural understanding of the role of myocilin in primary open angle glaucoma. (15693317)
2004
48
Low prevalence of MYOC mutations in UK primary open-angle glaucoma patients limits the utility of genetic testing. (15338275)
2004
49
Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene. (11992263)
2002
50
The severity and spatial distribution of visual field defects in primary glaucoma: a comparison of primary open-angle glaucoma and primary angle-closure glaucoma. (12470136)
2002

Genetic Variations for Primary Open Angle Glaucoma

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Expression for genes affiliated with Primary Open Angle Glaucoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Open Angle Glaucoma

Search GEO for disease gene expression data for Primary Open Angle Glaucoma.

Pathways for genes affiliated with Primary Open Angle Glaucoma

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Sources:
53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 51QIAGEN
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Pathways related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6TGFB2, ELN, LOXL1
2
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10.5GSTM1, CYP1B1
3
Hide members
10.5TGFB2, ELN
4
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10.5TGFB2, ELN

Compounds for genes affiliated with Primary Open Angle Glaucoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2412.9TGFB2, ELN, GSTM1, ABCA4, RHO
2valine4410.9ELN, GSTM1, CYP1B1, RHO
3ozone4410.8GSTM1, ELN, TGFB2
4cysteine4410.8COCH, RHO, MYOC, GSTM1, ELN, TGFB2
5benzo(a)pyrene4410.8CYP1B1, GSTM1, TGFB2
6betacarotene4410.8ELN, GSTM1, RHO
7ascorbic acid44 2411.8MYOC, GSTM1, ELN, TGFB2
8pyrene4410.8GSTM1, CYP1B1
91-hydroxypyrene4410.7GSTM1, CYP1B1
1011-cis-retinol44 2411.6RHO, ABCA4
11glycosaminoglycan4410.6TGFB2, ELN, MYOC
12p0034410.6CYP1B1, GSTM1, TGFB2
13phip4410.5GSTM1, CYP1B1
14dexamethasone44 49 28 1113.5TGFB2, ELN, CYP1B1, MYOC, OPTN
15arginine4410.3RHO, NTF4, MYOC, GSTM1, ELN

GO Terms for genes affiliated with Primary Open Angle Glaucoma

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16Gene Ontology
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Cellular components related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:09738110.5ABCA4, RHO

Biological processes related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760110.6ABCA4, CYP1B1, WDR36, RHO

Products for genes affiliated with Primary Open Angle Glaucoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Primary Open Angle Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet