MCID: PRM010
MIFTS: 51

Primary Open Angle Glaucoma malady

Summaries for Primary Open Angle Glaucoma

Sources:
47OMIM, 33MalaCards
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MalaCards: Primary Open Angle Glaucoma, also known as primary open-angle glaucoma, is related to ocular hypertension and exfoliation syndrome. An important gene associated with Primary Open Angle Glaucoma is WDR36 (WD repeat domain 36), and among its related pathways are Elastic fibre formation and Estrogen metabolism. The compounds vitamin a and valine have been mentioned in the context of this disorder. Affiliated tissues include brain, whole blood and cortex, and related mouse phenotype vision/eye.

Description from OMIM:47 137760

Aliases & Classifications for Primary Open Angle Glaucoma

Sources:
8Disease Ontology, 20GeneTests, 22GTR, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 40NCIt, 47OMIM, 27ICD9CM
See all sources

Aliases & Descriptions:

primary open angle glaucoma 8 10 45 31 61
primary open-angle glaucoma 8 20 22
chronic simple glaucoma 8


External Ids:

Disease Ontology8 DOID:1070
NCIt40 C35394
SNOMED-CT57 155122001, 77075001
OMIM47 137760
ICD9CM27 365.11

Related Diseases for Primary Open Angle Glaucoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the open-angle glaucoma family:

primary open angle glaucoma primary open angle glaucoma juvenile onset 1
glaucoma 1a, primary open angle glaucoma 3a, primary open angle, congenital, juvenile, or adult onset
glaucoma 1b, primary open angle, adult onset glaucoma 1c, primary open angle
glaucoma 1d, primary open angle glaucoma, primary open angle, juvenile-onset, 2
glaucoma 1, open angle, p glaucoma 1, open angle, i
glaucoma 1, open angle, 1o glaucoma 1k, primary open angle, juvenile-onset

Diseases related to Primary Open Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1ocular hypertension31.8OPTN, MYOC
2exfoliation syndrome30.9ELN, LOXL1
3primary open angle glaucoma juvenile onset 130.8MYOC, CYP1B1
4primary congenital glaucoma30.8CYP1B1
5blindness30.4OPTN, RHO, WDR36, MYOC, ABCA4
6juvenile glaucoma10.9
7glaucoma 1, open angle, g10.8
8glaucoma 1, open angle, p10.8
9cataract-glaucoma10.7
10glaucoma 1, open angle, e10.7
11glaucoma 1, open angle, m10.6
12h. pylori infection10.6
13glaucoma, congenital10.5
14early-onset glaucoma10.5
15glaucomatocyclitic crisis10.4
16kearns-sayre syndrome10.4
17n syndrome10.4
18say syndrome10.4
19glaucoma 1, open angle, i10.4
20neovascular glaucoma10.3
21cycloplegia10.3
22exudative vitreoretinopathy10.3
23central retinal vein occlusion10.3
24degenerative myopia10.3
25astigmatism10.3
26steroid-induced glaucoma10.3
27char syndrome10.3
28congenital stromal corneal dystrophy10.3
29encephalomyopathy10.3
30autonomic dysfunction10.3
31glaucoma 1a, primary open angle10.3
32glaucoma 1c, primary open angle10.3
33glaucoma 1, open angle, f10.3
34glaucoma 1d, primary open angle10.3
35glaucoma10.0TGFB2, ELN, CYP1B1, MYOC, NTF4, WDR36
36open-angle glaucoma10.0LOXL1, TGFB2, ELN, GSTM1, CYP1B1, MYOC
37eye disease10.0OPTN, RHO, MYOC, ABCA4, TGFB2
38glaucoma 3, primary congenital, d10.0CYP1B1, MYOC, OPTN
39optic nerve disease10.0OPTN, MYOC, ELN
40primary angle-closure glaucoma10.0MYOC
41retinitis10.0RHO
42peters plus syndrome10.0CYP1B1
43age related macular degeneration10.0RHO
44asthma10.0GSTM1, NTF4, RHO
45cataract10.0RHO, MYOC, TGFB2
46stargardt disease10.0ABCA4, RHO
47retinal detachment10.0TGFB2
48fundus dystrophy10.0ABCA4, RHO
49macular holes10.0TGFB2
50diabetic retinopathy10.0TGFB2, RHO

Graphical network of the top 20 diseases related to Primary Open Angle Glaucoma:



Diseases related to primary open angle glaucoma

Clinical Features for Primary Open Angle Glaucoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

137760

Drugs & Therapeutics for Primary Open Angle Glaucoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Primary Open Angle Glaucoma

Drug clinical trials:

Search ClinicalTrials for Primary Open Angle Glaucoma

Search NIH Clinical Center for Primary Open Angle Glaucoma

Search CenterWatch for Primary Open Angle Glaucoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Primary Open Angle Glaucoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Primary Open Angle Glaucoma:
Renexus
Embryonic/Adult Cultured Cells Related to Primary Open Angle Glaucoma:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Primary Open Angle Glaucoma

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Primary Open Angle Glaucoma:

id Genetic test Affiliating Genes
1 Primary Open Angle Glaucoma (adult Onset)20 22 WDR36
2 Primary Open Angle Glaucoma22

Anatomical Context for Primary Open Angle Glaucoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Primary Open Angle Glaucoma:

33
Brain, Whole blood, Cortex, Retina, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Primary Open Angle Glaucoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Primary Open Angle Glaucoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.6TGFB2, ABCA4, CYP1B1, MYOC, RHO, ATOH7

Publications for Primary Open Angle Glaucoma

Sources:
51PubMed
See all sources

Articles related to Primary Open Angle Glaucoma:

(show top 50)    (show all 745)
idTitleAuthorsYear
1
Association of single-nucleotide polymorphism rs4236601 near caveolin 1 and 2 with primary open-angle glaucoma: a meta-analysis. (24034151)
2013
2
Direct cost and predictive factors for treatment in patients with ocular hypertension or early, moderate and advanced primary open-angle glaucoma: the CoGIS study in Germany. (23624617)
2013
3
CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States. (23111177)
2013
4
Association of glutathione S-transferase polymorphisms (GSTM1 and GSTT1) with primary open-angle glaucoma: an evidence-based meta-analysis. (23747403)
2013
5
Increased expression of the transient receptor potential cation channel 6 gene in patients with primary open-angle glaucoma. (23566105)
2013
6
Investigation of known genetic risk factors for primary open angle glaucoma in two populations of African ancestry. (23963167)
2013
7
Comparative study of central corneal thickness using Fourier-domain optical coherence tomography versus ultrasound pachymetry in primary open-angle glaucoma. (22495027)
2013
8
Reduced white matter integrity in primary open-angle glaucoma: a DTI study using tract-based spatial statistics. (22796270)
2013
9
Helicobacter pylori infection and primary open-angle glaucoma: is there a connection? (22259235)
2012
10
Mitochondrial genetic background in Ghanaian patients with primary open-angle glaucoma. (22876121)
2012
11
Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination compared with the brimonidine/timolol-fixed combination in primary open-angle glaucoma. (21960068)
2012
12
The changing face of primary open-angle glaucoma in the United States: demographic and geographic changes from 2011 to 2050. (22541661)
2012
13
Pathogenesis of primary open-angle glaucoma. (23217143)
2012
14
Association of tumour necrosis factor-alpha -308 G/A polymorphism with primary open-angle glaucoma. (21575121)
2012
15
Absence of altered expression of optineurin in primary open angle glaucoma patients. (22690120)
2012
16
Quality of life of primary open angle glaucoma patients in lagos, Nigeria: clinical and sociodemographic correlates. (21336145)
2012
17
Aggregation and deformability of erythrocytes in primary open-angle glaucoma (POAG); the assessment of arterial hypertension. (22330771)
2012
18
Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension. (21728183)
2011
19
Comparison of fixed combinations of dorzolamide/timolol and brimonidine/timolol in patients with primary open-angle glaucoma. (22207522)
2011
20
Lactate dehydrogenase and oxidative stress activity in primary open-angle glaucoma aqueous humour. (20192938)
2010
21
The combination latanoprost-timolol versus twice daily 0.50% timolol administration either associated or not with latanoprost: efficacy and tolerability in the primary open-angle glaucoma. (20556928)
2010
22
Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma. (20357201)
2010
23
Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma. (20399928)
2010
24
Long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma. (21311650)
2010
25
Primary open-angle glaucoma. (19279343)
2009
26
High-resolution analysis of DNA copy number alterations in patients with primary open-angle glaucoma. (19693294)
2009
27
MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma. (19936026)
2009
28
Evaluation of the CYP1B1 gene as a candidate gene in beagles with primary open-angle glaucoma (POAG). (19956412)
2009
29
Coexistent primary open-angle glaucoma and cataract: interim analysis of a trabecular micro-bypass stent and concurrent cataract surgery. (19396784)
2009
30
Different WDR36 mutation pattern in Chinese patients with primary open-angle glaucoma. (19347049)
2009
31
Efficacy and safety of combination therapy with latanoprost after a change in therapeutic regimen from timolol to brinzolamide in Japanese adult patients with primary open-angle glaucoma and ocular hypertension: open, non-randomized 12-week study. (19668419)
2008
32
A study on the association of apolipoprotein E genotypes with primary open-angle glaucoma and primary angle-closure glaucoma in northeast of China]. (17706090)
2007
33
No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations. (18079692)
2007
34
The response of retrobulbar vasculature to hypercapnia in primary open-angle glaucoma and ocular hypertension. (17284932)
2007
35
Fluorescein filling defects of the optic nerve head in normal tension glaucoma, primary open-angle glaucoma, ocular hypertension and healthy controls. (16390479)
2006
36
TNF-alpha promoter polymorphisms and primary open-angle glaucoma. (16138112)
2006
37
Clinical phenotype of a Japanese family with primary open-angle glaucoma caused by a Ala 363 Thr mutation in the MYOC gene]. (16491872)
2006
38
Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. (16157798)
2005
39
Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. (15677485)
2005
40
Evaluation of Optineurin as a candidate gene in Indian patients with primary open angle glaucoma. (16205626)
2005
41
Gln48His is the prevalent myocilin mutation in primary open angle and primary congenital glaucoma phenotypes in India. (15723004)
2005
42
Distributions of p53 codon 72 polymorphism in primary open angle glaucoma. (12084746)
2002
43
Association of a single nucleotide polymorphism in the TIGR/MYOCILIN gene promoter with the severity of primary open-angle glaucoma. (11595024)
2001
44
Heredity in primary open-angle glaucoma. (10848214)
2000
45
Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma. (11004290)
2000
46
Reduced plasma cortisol binding to albumin in ocular hypertension and primary open-angle glaucoma. (10435834)
1999
47
Investigation of the 'fines' hypothesis of primary open-angle glaucoma: the possible role of alpha-crystallin. (9618718)
1998
48
Probable exclusion of GLC1A as a candidate glaucoma gene in a family with middle-age-onset primary open-angle glaucoma. (8684791)
1996
49
Spectrometric investigations in ocular hypertension and early stages of primary open angle glaucoma and of low tension glaucoma--multisubstance analysis. (1428553)
1992
50
Prevalence of migraine in low-tension glaucoma and primary open-angle glaucoma in Japanese. (2021590)
1991

Genetic Variations for Primary Open Angle Glaucoma

Expression for genes affiliated with Primary Open Angle Glaucoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Primary Open Angle Glaucoma

Search GEO for disease gene expression data for Primary Open Angle Glaucoma.

Pathways for genes affiliated with Primary Open Angle Glaucoma

Sources:
54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 52QIAGEN
See all sources

Pathways related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6TGFB2, ELN, LOXL1
2
Hide members
10.5GSTM1, CYP1B1
3
Hide members
10.5TGFB2, ELN
4
Hide members
10.5TGFB2, ELN

Compounds for genes affiliated with Primary Open Angle Glaucoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1vitamin a45 11 2412.9TGFB2, ELN, GSTM1, ABCA4, RHO
2valine4510.9ELN, GSTM1, CYP1B1, RHO
3ozone4510.8GSTM1, ELN, TGFB2
4cysteine4510.8COCH, RHO, MYOC, GSTM1, ELN, TGFB2
5benzo(a)pyrene4510.8CYP1B1, GSTM1, TGFB2
6betacarotene4510.8ELN, GSTM1, RHO
7ascorbic acid45 2411.8MYOC, GSTM1, ELN, TGFB2
8pyrene4510.8GSTM1, CYP1B1
91-hydroxypyrene4510.7GSTM1, CYP1B1
1011-cis-retinol45 2411.6RHO, ABCA4
11glycosaminoglycan4510.6TGFB2, ELN, MYOC
12p0034510.6CYP1B1, GSTM1, TGFB2
13phip4510.5GSTM1, CYP1B1
14dexamethasone45 50 29 1113.5TGFB2, ELN, CYP1B1, MYOC, OPTN
15arginine4510.3RHO, NTF4, MYOC, GSTM1, ELN

GO Terms for genes affiliated with Primary Open Angle Glaucoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:09738110.5ABCA4, RHO

Biological processes related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760110.6ABCA4, CYP1B1, WDR36, RHO

Products for genes affiliated with Primary Open Angle Glaucoma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Primary Open Angle Glaucoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet