MCID: PRM010
MIFTS: 55

Primary Open Angle Glaucoma malady

Genetic diseases, Eye diseases, Rare diseases, Fetal diseases categories
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Summaries for Primary Open Angle Glaucoma

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47OMIM, 33MalaCards
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MalaCards: Primary Open Angle Glaucoma, also known as primary open-angle glaucoma, is related to glaucoma and open-angle glaucoma. An important gene associated with Primary Open Angle Glaucoma is WDR36 (WD repeat domain 36), and among its related pathways are Estrogen metabolism and Elastic fibre formation. The compounds pyrene and tcdd have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotype vision/eye.

Description from OMIM:47 137760

Aliases & Classifications for Primary Open Angle Glaucoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 20GeneTests, 22GTR, 58SNOMED-CT, 27ICD9CM, 47OMIM, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Eye diseases


Aliases & Descriptions:

primary open angle glaucoma 8 10 45 31 62
primary open-angle glaucoma 8 20 22
chronic simple glaucoma 8


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Disease Ontology8 DOID:1070
ICD9CM27 365.11
SNOMED-CT58 155122001, 77075001
OMIM47 137760
NCIt40 C35394

Related Diseases for Primary Open Angle Glaucoma

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17GeneCards, 18GeneDecks
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Diseases in the Glaucoma 1a, Primary Open Angle family:

primary open angle glaucoma Open-Angle Glaucoma
Primary Open Angle Glaucoma Juvenile Onset 1 Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma 1b, Primary Open Angle, Adult Onset Glaucoma 1c, Primary Open Angle
Glaucoma 1d, Primary Open Angle Glaucoma, Primary Open Angle, Juvenile-Onset, 2
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, 1o Glaucoma 1k, Primary Open Angle, Juvenile-Onset

Diseases related to Primary Open Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma32.3WDR36, CYP1B1, TGFB2, MYOC, ELN, OPTN
2open-angle glaucoma32.3CYP1B1, TGFB2, MYOC, GSTM1, ELN, OPTN
3ocular hypertension31.9OPTN, MYOC
4primary angle-closure glaucoma31.5MYOC
5cataract31.0TGFB2, MYOC, RHO
6primary open angle glaucoma juvenile onset 130.9MYOC, OPTN
7primary congenital glaucoma30.8CYP1B1
8blindness30.4OPTN, WDR36, MYOC, RHO
9hypertension11.2
10retinitis10.9
11myopia10.8
12endotheliitis10.7
13exfoliation syndrome10.6
14low tension glaucoma10.6
15glaucoma 1, open angle, e10.5
16kearns-sayre syndrome10.4
17glaucomatocyclitic crisis10.4
18choroiditis10.4
19neuropathy10.4
20retinal vein occlusion10.4
21senile cataract10.4
22age related macular degeneration10.3
23neovascular glaucoma10.3
24juvenile glaucoma10.3
25central retinal vein occlusion10.3
26alzheimer's disease10.3
27degenerative myopia10.3
28cycloplegia10.3
29cerebritis10.3
30exudative vitreoretinopathy10.3
31astigmatism10.3
32dementia10.3
33keratoconus10.3
34migraine10.3
35mitochondrial encephalomyopathy10.3
36ocular hypotension10.3
37pancreatitis10.3
38pneumonia10.3
39refractive error10.3
40steroid-induced glaucoma10.3
41congenital stromal corneal dystrophy10.3
42encephalomyopathy10.3
43autonomic dysfunction10.3
44glaucoma 1c, primary open angle10.3
45glaucoma 1d, primary open angle10.3
46iridocyclitis10.1
47fundus dystrophy10.0RHO
48glaucoma 3, primary congenital, d10.0OPTN, MYOC, CYP1B1
49optic nerve disease10.0OPTN, ELN, MYOC
50keloids10.0ELN, TGFB2

Graphical network of the top 20 diseases related to Primary Open Angle Glaucoma:



Diseases related to primary open angle glaucoma

Symptoms for Primary Open Angle Glaucoma

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47OMIM
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Clinical features from OMIM:

137760

Drugs & Therapeutics for Primary Open Angle Glaucoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Primary Open Angle Glaucoma

Search NIH Clinical Center for Primary Open Angle Glaucoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Primary Open Angle Glaucoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Primary Open Angle Glaucoma:
Renexus
Embryonic/Adult Cultured Cells Related to Primary Open Angle Glaucoma:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Primary Open Angle Glaucoma

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Primary Open Angle Glaucoma:

id Genetic test Affiliating Genes
1 Primary Open Angle Glaucoma (adult Onset)20 22 WDR36
2 Primary Open Angle Glaucoma22

Anatomical Context for Primary Open Angle Glaucoma

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33MalaCards
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MalaCards organs/tissues related to Primary Open Angle Glaucoma:

33
Eye, Testes, Endothelial, Brain, Retina, Cortex

Animal Models for Primary Open Angle Glaucoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Primary Open Angle Glaucoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3RHO, MYOC, TGFB2, CYP1B1

Publications for Primary Open Angle Glaucoma

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52PubMed
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Articles related to Primary Open Angle Glaucoma:

(show top 50)    (show all 711)
idTitleAuthorsYear
1
Impaired Saccadic Eye Movement in Primary Open-angle Glaucoma. (22706338)
2014
2
Analysis of catalase SNP rs1001179 in Saudi patients with primary open angle glaucoma. (24215654)
2013
3
A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident primary open-angle glaucoma. (23412091)
2013
4
The efficacy of viscocanalostomy for uncontrollable primary open-angle glaucoma in a developing country. (23412524)
2013
5
Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry. (23595371)
2013
6
Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. (23638916)
2013
7
Neurodegenerative Genes Polymorphisms of the -491A/T APOE, the -877T/C APP and the Risk of Primary Open-angle Glaucoma in the Polish Population. (24073598)
2013
8
Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging. (23258150)
2013
9
Primary open-angle glaucoma: Reader feedback. (23840091)
2013
10
Sensory stimulation for lowering intraocular pressure, improving blood flow to the optic nerve and neuroprotection in primary open-angle glaucoma. (24008011)
2013
11
Helicobacter pylori infection and primary open-angle glaucoma: is there a connection? (22259235)
2012
12
Clock-hour laminar displacement and age in primary open-angle glaucoma and normal tension glaucoma. (21875431)
2012
13
Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. (22561696)
2012
14
An observational study of bimatoprost 0.01% in treatment-naA^ve patients with primary open angle glaucoma or ocular hypertension: the CLEAR trial. (23269858)
2012
15
Primary open-angle glaucoma: everyone's business. (23520411)
2012
16
Mitochondrial genetic background in Ghanaian patients with primary open-angle glaucoma. (22876121)
2012
17
Effect of topical Beta blocker (Timolol maleate 0.5%) in primary open angle glaucoma. (23134912)
2012
18
A tertiary level hospital-based study on frequency of changing presbyopic glasses in primary open angle glaucoma patients. (23025223)
2012
19
GSTM1 polymorphism in patients with primary open-angle glaucoma. (23079819)
2012
20
Hyaluronic acid increases MMP-2 and MMP-9 expressions in cultured trabecular meshwork cells from patients with primary open-angle glaucoma. (22605928)
2012
21
Impaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts. (22427588)
2012
22
Common TGFI^2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma. (22736943)
2012
23
Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination compared with the brimonidine/timolol-fixed combination in primary open-angle glaucoma. (21960068)
2012
24
Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension. (21728183)
2011
25
Myocilin mt.1 gene promoter single nucleotide polymorphism (-1000C>G) in Brazilian patients with primary open angle glaucoma. (21174523)
2011
26
Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye. (21743018)
2011
27
Study on MYOC/TIGR gene mutations in primary open-angle glaucoma]. (21426841)
2011
28
Alzheimer's disease and primary open-angle glaucoma: is there a connection? (21760717)
2011
29
Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma. (20673200)
2010
30
Retinal arteriolar vascular reactivity in untreated and progressive primary open-angle glaucoma. (19907031)
2010
31
Efficacy and safety of prostaglandin analogues in patients with predominantly primary open-angle glaucoma or ocular hypertension: a meta-analysis. (19684868)
2009
32
Healthcare charges in patients who transition from ocular hypertension to primary open-angle glaucoma based on ophthalmic coding data. (19907929)
2009
33
Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma. (19662433)
2009
34
Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population. (19471604)
2009
35
Primary open-angle glaucoma. (19535810)
2009
36
Biometric characteristics of eyes with exfoliation syndrome and occludable as well as open angles and eyes with primary open-angle glaucoma. (19169317)
2009
37
Comparative biometric study between plateau iris configuration and primary open angle glaucoma with narrow angle. (19668957)
2009
38
Lack of association of three primary open-angle glaucoma-susceptible loci with primary glaucomas in an Indian population. (19846772)
2009
39
Corneal hysteresis: a useful tool in the diagnosis and management of primary open angle glaucoma. (19780378)
2009
40
Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. (18293187)
2008
41
Comparison of twice-daily and three-times-daily dosing of dorzolamide in ocular hypertension and primary open-angle glaucoma patients treated with latanoprost. (18369537)
2008
42
Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost in patients with primary open angle glaucoma or ocular hypertension. (16488953)
2006
43
Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. (16157798)
2005
44
Distribution of oxidation enzyme eNOS and myeloperoxidase in primary open angle glaucoma. (15756709)
2005
45
Novel MYOC gene mutation, Phe369Leu, in Japanese patients with primary open-angle glaucoma detected by denaturing high-performance liquid chromatography. (15534471)
2004
46
Identification of a new GLC1A mutation in a sporadic, primary open-angle glaucoma in Japan. (12851728)
2003
47
Evaluation and understanding of myocilin mutations in Indian primary open angle glaucoma patients. (14627955)
2003
48
Distributions of p53 codon 72 polymorphism in primary open angle glaucoma. (12084746)
2002
49
Prevalence of migraine in low-tension glaucoma and primary open-angle glaucoma in Japanese. (2021590)
1991
50
Surgical treatment of acute glaucomatocyclitic crisis in a patient with primary open-angle glaucoma. (3337205)
1988

Variations for Primary Open Angle Glaucoma

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Expression for genes affiliated with Primary Open Angle Glaucoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Open Angle Glaucoma

Search GEO for disease gene expression data for Primary Open Angle Glaucoma.

Pathways for genes affiliated with Primary Open Angle Glaucoma

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Sources:
50PathCards, 38NCBI BioSystems Database, 51PharmGKB, 55Reactome, 30KEGG, 60Thomson Reuters
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Pathways related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4GSTM1, CYP1B1
2
Show member pathways
9.4ELN, TGFB2
3
Show member pathways
Retinol metabolism60
9.2RHO, CYP1B1

Compounds for genes affiliated with Primary Open Angle Glaucoma

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1pyrene459.9GSTM1, CYP1B1
2tcdd459.9CYP1B1, TGFB2
31-hydroxypyrene459.9GSTM1, CYP1B1
4phip459.8CYP1B1, GSTM1
5cotinine45 2410.8GSTM1, CYP1B1
6aflatoxin b145 2410.8CYP1B1, GSTM1
7hydrocarbons459.8CYP1B1, GSTM1
8deoxypyridinoline459.8ELN, TGFB2
9doxycycline45 1110.8CYP1B1, ELN
104-hydroxytamoxifen459.8TGFB2, CYP1B1
11alginate459.8ELN, TGFB2
12quinone45 2410.8GSTM1, CYP1B1
13epoxide459.7GSTM1, CYP1B1
14oxaliplatin45 51 1111.7GSTM1, CYP1B1
15benzene459.7ELN, GSTM1
16theophylline45 29 24 1112.7ELN, CYP1B1
17glycosaminoglycan459.5TGFB2, MYOC, ELN
18hyaluronic acid45 2410.5ELN, MYOC, TGFB2
19n acetylcysteine459.4ELN, TGFB2, CYP1B1
20benzo(a)pyrene459.4GSTM1, TGFB2, CYP1B1
21p003459.3GSTM1, TGFB2, CYP1B1
22bleomycin45 1110.3ELN, GSTM1
23genistein45 29 61 3 24 1114.3ELN, TGFB2, CYP1B1
245fluorouracil459.3GSTM1, TGFB2, CYP1B1
25ozone459.3GSTM1, ELN, TGFB2
26vitamin d459.2GSTM1, ELN, TGFB2
27phenobarbital45 29 51 1112.1GSTM1, CYP1B1
28amine459.1RHO, ELN
29carbon459.1CYP1B1, ELN, RHO
30cycloheximide459.1CYP1B1, TGFB2, MYOC, ELN
31leucine459.0CYP1B1, MYOC, RHO
32proline459.0CYP1B1, ELN, RHO
33creatinine459.0GSTM1, ELN, TGFB2
34betacarotene458.9RHO, GSTM1, ELN
354-hydroxynonenal45 249.9RHO, GSTM1
36ascorbic acid45 249.9TGFB2, MYOC, ELN, GSTM1
37testosterone45 61 24 1111.8GSTM1, ELN, TGFB2, CYP1B1
38dopamine45 29 24 1111.8RHO, GSTM1, TGFB2
39estrogen458.7CYP1B1, TGFB2, ELN, GSTM1
40dexamethasone45 51 29 1111.7OPTN, ELN, MYOC, TGFB2, CYP1B1
41aspartate458.7ELN, GSTM1, RHO
42heparin45 29 24 1111.7RHO, ELN, TGFB2
43glutamate458.6CYP1B1, TGFB2, ELN, RHO
44valine458.5RHO, GSTM1, ELN, CYP1B1
45retinoic acid45 249.5RHO, ELN, TGFB2, CYP1B1
46arginine458.5RHO, GSTM1, ELN, MYOC
47vitamin a45 24 1110.4TGFB2, ELN, GSTM1, RHO
48cysteine457.6TGFB2, MYOC, ELN, COCH, GSTM1, RHO

GO Terms for genes affiliated with Primary Open Angle Glaucoma

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16Gene Ontology
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Biological processes related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6MYOC, TGFB2
2blood vessel remodelingGO:0019749.1ELN, TGFB2
3visual perceptionGO:0076018.8RHO, WDR36, CYP1B1

Products for genes affiliated with Primary Open Angle Glaucoma

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  • Antibodies
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Sources for Primary Open Angle Glaucoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet