MCID: PRM010
MIFTS: 55

Primary Open Angle Glaucoma malady

Genetic diseases, Eye diseases, Rare diseases, Fetal diseases categories
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Summaries for Primary Open Angle Glaucoma

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MalaCards based summary: Primary Open Angle Glaucoma, also known as chronic simple glaucoma, is related to ocular hypertension and primary angle-closure glaucoma. An important gene associated with Primary Open Angle Glaucoma is WDR36 (WD repeat domain 36), and among its related pathways are Estrogen metabolism and Elastic fibre formation. The compounds pyrene and tcdd have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotype vision/eye.

Description from OMIM:46 137760

Aliases & Classifications for Primary Open Angle Glaucoma

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Primary Open Angle Glaucoma, Aliases & Descriptions:

Name: Primary Open Angle Glaucoma 30 8 20 22 10 44 62
 
Chronic Simple Glaucoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:1070
ICD9CM27 365.11
SNOMED-CT57 77075001, 155122001
OMIM46 137760
NCIt39 C35394

Related Diseases for Primary Open Angle Glaucoma

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Diseases in the Glaucoma 1a, Primary Open Angle family:

primary open angle glaucoma Open-Angle Glaucoma
Primary Open Angle Glaucoma Juvenile Onset 1 Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma 1b, Primary Open Angle, Adult Onset Glaucoma 1c, Primary Open Angle
Glaucoma 1d, Primary Open Angle Glaucoma, Primary Open Angle, Juvenile-Onset, 2
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, 1o Glaucoma 1k, Primary Open Angle, Juvenile-Onset

Diseases related to Primary Open Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1ocular hypertension32.3OPTN, MYOC
2primary angle-closure glaucoma32.0MYOC
3open-angle glaucoma31.5CYP1B1, TGFB2, MYOC, GSTM1, ELN, OPTN
4primary congenital glaucoma31.3CYP1B1
5primary open angle glaucoma juvenile onset 131.2MYOC, OPTN
6cataract30.8TGFB2, MYOC, RHO
7blindness30.1OPTN, WDR36, MYOC, RHO
8hypertension11.2
9retinitis11.0
10myopia10.8
11endotheliitis10.7
12exfoliation syndrome10.7
13low tension glaucoma10.6
14choroiditis10.5
15glaucoma 1, open angle, e10.5
16alzheimer's disease10.5
17retinal vein occlusion10.5
18kearns-sayre syndrome10.5
19glaucomatocyclitic crisis10.5
20cerebritis10.5
21dementia10.5
22neuropathy10.5
23ocular hypotension10.5
24senile cataract10.5
25age related macular degeneration10.3
26keratoconus10.3
27central retinal vein occlusion10.3
28neovascular glaucoma10.3
29juvenile glaucoma10.3
30degenerative myopia10.3
31cycloplegia10.3
32vascular dementia10.3
33exudative vitreoretinopathy10.3
34conjunctivochalasis10.3
35astigmatism10.3
36migraine10.3
37mitochondrial encephalomyopathy10.3
38pancreatitis10.3
39pneumonia10.3
40refractive error10.3
41steroid-induced glaucoma10.3
42congenital stromal corneal dystrophy10.3
43encephalomyopathy10.3
44autonomic dysfunction10.3
45glaucoma 1a, primary open angle10.3
46glaucoma 1c, primary open angle10.3
47glaucoma 1d, primary open angle10.3
48iridocyclitis10.2
49fundus dystrophy10.1RHO
50glaucoma 3a, primary open angle, congenital, juvenile, or adult onset10.1OPTN, MYOC, CYP1B1

Graphical network of the top 20 diseases related to Primary Open Angle Glaucoma:



Diseases related to primary open angle glaucoma

Symptoms for Primary Open Angle Glaucoma

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Clinical features from OMIM:

137760

Drugs & Therapeutics for Primary Open Angle Glaucoma

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Drug clinical trials:

Search ClinicalTrials for Primary Open Angle Glaucoma

Search NIH Clinical Center for Primary Open Angle Glaucoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Primary Open Angle Glaucoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Primary Open Angle Glaucoma:
Renexus
Embryonic/Adult Cultured Cells Related to Primary Open Angle Glaucoma:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Primary Open Angle Glaucoma

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Genetic tests related to Primary Open Angle Glaucoma:

id Genetic test Affiliating Genes
1 Primary Open Angle Glaucoma (adult Onset)20 22 WDR36
2 Primary Open Angle Glaucoma22

Anatomical Context for Primary Open Angle Glaucoma

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MalaCards organs/tissues related to Primary Open Angle Glaucoma:

32
Eye, Testes, Endothelial, Brain, Cortex, Retina

Animal Models for Primary Open Angle Glaucoma or affiliated genes

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MGI Mouse Phenotypes related to Primary Open Angle Glaucoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3RHO, MYOC, TGFB2, CYP1B1

Publications for Primary Open Angle Glaucoma

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Articles related to Primary Open Angle Glaucoma:

(show top 50)    (show all 736)
idTitleAuthorsYear
1
Impaired Saccadic Eye Movement in Primary Open-angle Glaucoma. (22706338)
2014
2
Latrunculin B Reduces Intraocular Pressure in Human Ocular Hypertension and Primary Open-Angle Glaucoma. (25237590)
2014
3
Fixed combination of latanoprost and timolol vs the individual components for primary open angle glaucoma and ocular hypertension: a systematic review and meta-analysis. (25349811)
2014
4
Cerebral Microinfarcts in Primary Open-Angle Glaucoma Correlated With DTI-Derived Integrity of Optic Radiation. (25277233)
2014
5
Analysis of catalase SNP rs1001179 in Saudi patients with primary open angle glaucoma. (24215654)
2013
6
A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident primary open-angle glaucoma. (23412091)
2013
7
The efficacy of viscocanalostomy for uncontrollable primary open-angle glaucoma in a developing country. (23412524)
2013
8
Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry. (23595371)
2013
9
Genetic Variation of Superoxide Dismutases in Patients with Primary Open-angle Glaucoma. (23638916)
2013
10
Neurodegenerative Genes Polymorphisms of the -491A/T APOE, the -877T/C APP and the Risk of Primary Open-angle Glaucoma in the Polish Population. (24073598)
2013
11
Structural brain abnormalities in patients with primary open-angle glaucoma: a study with 3T MR imaging. (23258150)
2013
12
Primary open-angle glaucoma: Reader feedback. (23840091)
2013
13
Sensory stimulation for lowering intraocular pressure, improving blood flow to the optic nerve and neuroprotection in primary open-angle glaucoma. (24008011)
2013
14
Helicobacter pylori infection and primary open-angle glaucoma: is there a connection? (22259235)
2012
15
Clock-hour laminar displacement and age in primary open-angle glaucoma and normal tension glaucoma. (21875431)
2012
16
Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population. (22561696)
2012
17
An observational study of bimatoprost 0.01% in treatment-naA^ve patients with primary open angle glaucoma or ocular hypertension: the CLEAR trial. (23269858)
2012
18
Primary open-angle glaucoma: everyone's business. (23520411)
2012
19
Mitochondrial genetic background in Ghanaian patients with primary open-angle glaucoma. (22876121)
2012
20
Effect of topical Beta blocker (Timolol maleate 0.5%) in primary open angle glaucoma. (23134912)
2012
21
A tertiary level hospital-based study on frequency of changing presbyopic glasses in primary open angle glaucoma patients. (23025223)
2012
22
GSTM1 polymorphism in patients with primary open-angle glaucoma. (23079819)
2012
23
Hyaluronic acid increases MMP-2 and MMP-9 expressions in cultured trabecular meshwork cells from patients with primary open-angle glaucoma. (22605928)
2012
24
Impaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts. (22427588)
2012
25
Common TGFI^2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma. (22736943)
2012
26
Mixed treatment comparison of repeated measurements of a continuous endpoint: an example using topical treatments for primary open-angle glaucoma and ocular hypertension. (21728183)
2011
27
Myocilin mt.1 gene promoter single nucleotide polymorphism (-1000C>G) in Brazilian patients with primary open angle glaucoma. (21174523)
2011
28
Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye. (21743018)
2011
29
Study on MYOC/TIGR gene mutations in primary open-angle glaucoma]. (21426841)
2011
30
Alzheimer's disease and primary open-angle glaucoma: is there a connection? (21760717)
2011
31
Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma. (20673200)
2010
32
Retinal arteriolar vascular reactivity in untreated and progressive primary open-angle glaucoma. (19907031)
2010
33
Efficacy and safety of prostaglandin analogues in patients with predominantly primary open-angle glaucoma or ocular hypertension: a meta-analysis. (19684868)
2009
34
Healthcare charges in patients who transition from ocular hypertension to primary open-angle glaucoma based on ophthalmic coding data. (19907929)
2009
35
Myocilin in the trabecular meshwork of eyes with primary open-angle glaucoma. (19662433)
2009
36
Lack of association between p53 gene polymorphisms and primary open angle glaucoma in the Japanese population. (19471604)
2009
37
Primary open-angle glaucoma. (19535810)
2009
38
Biometric characteristics of eyes with exfoliation syndrome and occludable as well as open angles and eyes with primary open-angle glaucoma. (19169317)
2009
39
Comparative biometric study between plateau iris configuration and primary open angle glaucoma with narrow angle. (19668957)
2009
40
Lack of association of three primary open-angle glaucoma-susceptible loci with primary glaucomas in an Indian population. (19846772)
2009
41
Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension. (18293187)
2008
42
Comparison of twice-daily and three-times-daily dosing of dorzolamide in ocular hypertension and primary open-angle glaucoma patients treated with latanoprost. (18369537)
2008
43
Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost in patients with primary open angle glaucoma or ocular hypertension. (16488953)
2006
44
Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. (16157798)
2005
45
Distribution of oxidation enzyme eNOS and myeloperoxidase in primary open angle glaucoma. (15756709)
2005
46
Novel MYOC gene mutation, Phe369Leu, in Japanese patients with primary open-angle glaucoma detected by denaturing high-performance liquid chromatography. (15534471)
2004
47
Identification of a new GLC1A mutation in a sporadic, primary open-angle glaucoma in Japan. (12851728)
2003
48
Distributions of p53 codon 72 polymorphism in primary open angle glaucoma. (12084746)
2002
49
Prevalence of migraine in low-tension glaucoma and primary open-angle glaucoma in Japanese. (2021590)
1991
50
Surgical treatment of acute glaucomatocyclitic crisis in a patient with primary open-angle glaucoma. (3337205)
1988

Variations for Primary Open Angle Glaucoma

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Expression for genes affiliated with Primary Open Angle Glaucoma

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Expression patterns in normal tissues for genes affiliated with Primary Open Angle Glaucoma

Search GEO for disease gene expression data for Primary Open Angle Glaucoma.

Pathways for genes affiliated with Primary Open Angle Glaucoma

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Pathways related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4GSTM1, CYP1B1
2
Show member pathways
9.4ELN, TGFB2
3
Show member pathways
Retinol metabolism60
9.2RHO, CYP1B1

Compounds for genes affiliated with Primary Open Angle Glaucoma

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Compounds related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1pyrene449.9GSTM1, CYP1B1
2tcdd449.9CYP1B1, TGFB2
31-hydroxypyrene449.9GSTM1, CYP1B1
4phip449.8GSTM1, CYP1B1
5cotinine44 2410.8GSTM1, CYP1B1
6aflatoxin b144 2410.8GSTM1, CYP1B1
7hydrocarbons449.8CYP1B1, GSTM1
8deoxypyridinoline449.8TGFB2, ELN
9doxycycline44 1110.8ELN, CYP1B1
104-hydroxytamoxifen449.8TGFB2, CYP1B1
11alginate449.8ELN, TGFB2
12quinone44 2410.8GSTM1, CYP1B1
13epoxide449.7GSTM1, CYP1B1
14oxaliplatin44 50 1111.7GSTM1, CYP1B1
15benzene449.7GSTM1, ELN
16theophylline44 28 24 1112.7CYP1B1, ELN
17glycosaminoglycan449.5MYOC, TGFB2, ELN
18hyaluronic acid44 2410.5ELN, MYOC, TGFB2
19n acetylcysteine449.4CYP1B1, ELN, TGFB2
20benzo(a)pyrene449.4TGFB2, GSTM1, CYP1B1
21p003449.3TGFB2, GSTM1, CYP1B1
22bleomycin44 1110.3ELN, GSTM1
23genistein44 28 61 2 24 1114.3CYP1B1, ELN, TGFB2
245fluorouracil449.3CYP1B1, TGFB2, GSTM1
25ozone449.3TGFB2, ELN, GSTM1
26vitamin d449.2ELN, GSTM1, TGFB2
27phenobarbital44 28 50 1112.1GSTM1, CYP1B1
28amine449.1ELN, RHO
29carbon449.1CYP1B1, ELN, RHO
30cycloheximide449.1CYP1B1, TGFB2, MYOC, ELN
31leucine449.0RHO, CYP1B1, MYOC
32proline449.0CYP1B1, RHO, ELN
33creatinine449.0ELN, TGFB2, GSTM1
34betacarotene448.9RHO, ELN, GSTM1
354-hydroxynonenal44 249.9GSTM1, RHO
36ascorbic acid44 249.9ELN, TGFB2, GSTM1, MYOC
37testosterone44 61 24 1111.8TGFB2, CYP1B1, GSTM1, ELN
38dopamine44 28 24 1111.8RHO, TGFB2, GSTM1
39estrogen448.7ELN, TGFB2, GSTM1, CYP1B1
40dexamethasone44 50 28 1111.7ELN, OPTN, MYOC, TGFB2, CYP1B1
41heparin44 28 24 1111.7RHO, ELN, TGFB2
42aspartate448.7ELN, GSTM1, RHO
43glutamate448.6ELN, RHO, CYP1B1, TGFB2
44valine448.5RHO, CYP1B1, ELN, GSTM1
45retinoic acid44 249.5ELN, RHO, TGFB2, CYP1B1
46arginine448.5ELN, RHO, GSTM1, MYOC
47vitamin a44 24 1110.4TGFB2, ELN, RHO, GSTM1
48cysteine447.6MYOC, RHO, GSTM1, TGFB2, COCH, ELN

GO Terms for genes affiliated with Primary Open Angle Glaucoma

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Biological processes related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.6MYOC, TGFB2
2blood vessel remodelingGO:0019749.1ELN, TGFB2
3visual perceptionGO:0076018.8RHO, WDR36, CYP1B1

Products for genes affiliated with Primary Open Angle Glaucoma

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Sources for Primary Open Angle Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet