MCID: PRM010
MIFTS: 51

Primary Open Angle Glaucoma malady

Summaries for Primary Open Angle Glaucoma

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46OMIM, 32MalaCards
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MalaCards: Primary Open Angle Glaucoma, also known as primary open-angle glaucoma, is related to glaucoma and open-angle glaucoma. An important gene associated with Primary Open Angle Glaucoma is WDR36 (WD repeat domain 36), and among its related pathways are Elastic fibre formation and Estrogen metabolism. The compounds vitamin a and valine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotype vision/eye.

Description from OMIM:46 137760

Aliases & Classifications for Primary Open Angle Glaucoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 20GeneTests, 22GTR, 56SNOMED-CT, 39NCIt, 46OMIM, 27ICD9CM
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Aliases & Descriptions:

primary open angle glaucoma 8 10 44 30 60
primary open-angle glaucoma 8 20 22
chronic simple glaucoma 8


External Ids:

Disease Ontology8 DOID:1070
NCIt39 C35394
SNOMED-CT56 155122001, 77075001
OMIM46 137760
ICD9CM27 365.11

Related Diseases for Primary Open Angle Glaucoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Glaucoma 1a, Primary Open Angle family:

primary open angle glaucoma Open-Angle Glaucoma
Primary Open Angle Glaucoma Juvenile Onset 1 Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma 1b, Primary Open Angle, Adult Onset Glaucoma 1c, Primary Open Angle
Glaucoma 1d, Primary Open Angle Glaucoma, Primary Open Angle, Juvenile-Onset, 2
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, 1o Glaucoma 1k, Primary Open Angle, Juvenile-Onset

Diseases related to Primary Open Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma32.5TGFB2, ELN, CYP1B1, MYOC, NTF4, WDR36
2open-angle glaucoma32.5LOXL1, TGFB2, ELN, GSTM1, CYP1B1, MYOC
3ocular hypertension31.7OPTN, MYOC
4primary angle-closure glaucoma31.4MYOC
5retinitis31.3RHO
6cataract31.0RHO, MYOC, TGFB2
7exfoliation syndrome30.9ELN, LOXL1
8primary congenital glaucoma30.7CYP1B1
9primary open angle glaucoma juvenile onset 130.7MYOC, CYP1B1
10age related macular degeneration30.4RHO
11hypertension11.2
12juvenile glaucoma10.9
13myopia10.7
14low tension glaucoma10.6
15glaucoma 1, open angle, e10.5
16choroiditis10.4
17glaucomatocyclitic crisis10.4
18kearns-sayre syndrome10.4
19neuropathy10.4
20retinal vein occlusion10.4
21senile cataract10.4
22steroid-induced glaucoma - borderline10.3
23neovascular glaucoma10.3
24cycloplegia10.3
25cerebritis10.3
26exudative vitreoretinopathy10.3
27central retinal vein occlusion10.3
28alzheimer's disease10.3
29degenerative myopia10.3
30astigmatism10.3
31dementia10.3
32intracranial hypertension10.3
33keratoconus10.3
34migraine10.3
35mitochondrial encephalomyopathy10.3
36ocular hypotension10.3
37pancreatitis10.3
38pneumonia10.3
39refractive error10.3
40steroid-induced glaucoma10.3
41congenital stromal corneal dystrophy10.3
42glaucoma 1a, primary open angle10.3
43glaucoma 1c, primary open angle10.3
44glaucoma 1d, primary open angle10.3
45iridocyclitis10.1
46eye disease10.0OPTN, RHO, MYOC, ABCA4, TGFB2
47glaucoma 3, primary congenital, d10.0CYP1B1, MYOC, OPTN
48optic nerve disease10.0OPTN, MYOC, ELN
49blindness10.0OPTN, RHO, WDR36, MYOC, ABCA4
50peters plus syndrome10.0CYP1B1

Graphical network of the top 20 diseases related to Primary Open Angle Glaucoma:



Diseases related to primary open angle glaucoma

Clinical Features for Primary Open Angle Glaucoma

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46OMIM
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Clinical features from OMIM:

137760

Drugs & Therapeutics for Primary Open Angle Glaucoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Primary Open Angle Glaucoma

Drug clinical trials:

Search ClinicalTrials for Primary Open Angle Glaucoma

Search NIH Clinical Center for Primary Open Angle Glaucoma

Search CenterWatch for Primary Open Angle Glaucoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Primary Open Angle Glaucoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Primary Open Angle Glaucoma:
Renexus
Embryonic/Adult Cultured Cells Related to Primary Open Angle Glaucoma:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Primary Open Angle Glaucoma

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20GeneTests, 22GTR
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Genetic tests related to Primary Open Angle Glaucoma:

id Genetic test Affiliating Genes
1 Primary Open Angle Glaucoma (adult Onset)20 22 WDR36
2 Primary Open Angle Glaucoma22

Anatomical Context for Primary Open Angle Glaucoma

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32MalaCards
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MalaCards organs/tissues related to Primary Open Angle Glaucoma:

32
Eye, Testes, Endothelial, Brain, Retina, Cortex

Animal Models for Primary Open Angle Glaucoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Primary Open Angle Glaucoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.6TGFB2, ABCA4, CYP1B1, MYOC, RHO, ATOH7

Publications for Primary Open Angle Glaucoma

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50PubMed
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Articles related to Primary Open Angle Glaucoma:

(show top 50)    (show all 745)
idTitleAuthorsYear
1
Analysis of catalase SNP rs1001179 in Saudi patients with primary open angle glaucoma. (24215654)
2013
2
Retinal nerve fiber layer in primary open-angle glaucoma with high myopia determined by optical coherence tomography and scanning laser polarimetry. (23595371)
2013
3
Analysis of COCH and TNFA variants in East Indian primary open-angle glaucoma patients. (24063017)
2013
4
Gene polymorphisms of the MMP1, MMP9, MMP12, IL-1I^ and TIMP1 and the risk of primary open-angle glaucoma. (23800300)
2013
5
Role of rs1533428 and rs12994401 in patients with Primary Open Angle Glaucoma in an European population. (23136999)
2013
6
Bilateral Juvenile Onset Primary Open-angle Glaucoma Among Keratoconus Patients. (24240878)
2013
7
Anxiety and Depression are More Prevalent in Primary Angle Closure Glaucoma Than in Primary Open-Angle Glaucoma. (24240874)
2013
8
Comparison of the efficacy and safety of bimatoprost (0.03 %) and travoprost (0.004 %) in patients with primary open angle glaucoma. (23584651)
2013
9
Single nucleotide polymorphism of MYOC affected the severity of primary open angle glaucoma. (23826516)
2013
10
An observational study of bimatoprost 0.01% in treatment-naA^ve patients with primary open angle glaucoma or ocular hypertension: the CLEAR trial. (23269858)
2012
11
GSTM1 polymorphism in patients with primary open-angle glaucoma. (23079819)
2012
12
Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy. (22731245)
2012
13
The effect of intraocular pressure on visual field after trabeculectomy in patients with primary open angle glaucoma. (22924306)
2012
14
Comparison of dorzolamide/timolol and latanoprost/timolol fixed combinations on diurnal intraocular pressure control in primary open-angle glaucoma. (22320418)
2012
15
Myocilin polymorphisms and primary open-angle glaucoma: a systematic review and meta-analysis. (23029558)
2012
16
Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye. (21743018)
2011
17
Comparison of ocular response analyzer parameters in chinese subjects with primary angle-closure and primary open-angle glaucoma. (21482869)
2011
18
24-Hour intraocular pressure control between travoprost/timolol fixed combination, latanoprost/ timolol fixed combination and standard timolol in primary open angle glaucoma and ocular hypertension. (21717884)
2011
19
Short-term results of canaloplasty surgery for primary open-angle glaucoma in Japanese patients. (21475647)
2011
20
Antioxidant status and oxidative stress in primary open angle glaucoma and pseudoexfoliative glaucoma. (21780920)
2011
21
Conjunctival inflammatory cells and their predictive role for deep sclerectomy in primary open-angle glaucoma and exfoliation glaucoma. (20577105)
2011
22
New mutation in the MYOC gene and its association with primary open-angle glaucoma in a Chinese family. (19688280)
2010
23
Using the Utah Population Database to assess familial risk of primary open angle glaucoma. (20858511)
2010
24
Prevalence of and risk factors for primary open-angle glaucoma in central Sri Lanka: the Kandy eye study. (20642343)
2010
25
Long-term benefit of reduced intraocular pressure in primary open-angle glaucoma patients in Ethiopia. (19882542)
2010
26
Diurnal IOP-lowering efficacy and safety of travoprost 0.004% compared with tafluprost 0.0015% in patients with primary open-angle glaucoma or ocular hypertension. (21191441)
2010
27
Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use. (19815736)
2010
28
Efficacy of Garcinia kola 0.5% Aqueous Eye Drops in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension. (20543944)
2010
29
Oxidative stress markers in patients with primary open-angle glaucoma. (20373896)
2010
30
Corneal hysteresis: a useful tool in the diagnosis and management of primary open angle glaucoma. (19780378)
2009
31
Smoking, an additional risk factor in elder women with primary open-angle glaucoma. (20057902)
2009
32
Ocular hypotensive efficacy and safety of travoprost 0.004% in inadequately controlled primary open-angle glaucoma or ocular hypertension: short-term, multicenter, prospective study. (19210139)
2009
33
A comparison of 180 degrees of treatment with diode laser trabeculoplasty in primary open-angle glaucoma and exfoliation glaucoma: a short-term study of 22 patients. (19274527)
2009
34
Genetic risk for primary open-angle glaucoma determined by LMX1B haplotypes. (18952915)
2009
35
Effects of brinzolamide vs timolol as an adjunctive medication to latanoprost on circadian intraocular pressure control in primary open-angle glaucoma Japanese patients. (19750124)
2009
36
Central corneal thickness measurements in ocular hypertension, primary open angle glaucoma, glaucoma suspects and control subjects. (18543786)
2008
37
Transforming growth factor beta-1 -509C>T polymorphism in Indian patients with primary open angle glaucoma. (17570736)
2007
38
Medical interventions for primary open angle glaucoma and ocular hypertension. (17943780)
2007
39
Confirmation of the adult-onset primary open angle glaucoma locus GLC1B at 2cen-q13 in an Australian family. (16374045)
2006
40
Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma. (16723468)
2006
41
Heidelberg Retinal Tomograph (HRT 2) parameters in primary open angle glaucoma and primary angle closure glaucoma: a comparative study in an Indian population. (17060113)
2006
42
Genetic analysis of an Indian family with members affected with juvenile-onset primary open-angle glaucoma. (15255110)
2004
43
Rate of visual field progression in primary open-angle glaucoma and primary angle-closure glaucoma. (15635823)
2004
44
Evaluation and understanding of myocilin mutations in Indian primary open angle glaucoma patients. (14627955)
2003
45
Analysis of myocilin gene mutations in Japanese patients with normal tension glaucoma and primary open-angle glaucoma. (11298682)
2001
46
Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. (11040079)
2000
47
Comparison of symptomatic and asymptomatic, chronic, primary angle-closure glaucoma, open-angle glaucoma, and controls. (10877370)
2000
48
TIGR gene in primary open-angle glaucoma and steroid-induced glaucoma. (9510647)
1997
49
Optic disc size in exfoliative, primary open angle, and low-tension glaucoma. (1736870)
1992
50
Glaucomatocyclitic crisis and primary open-angle glaucoma. (4696670)
1973

Genetic Variations for Primary Open Angle Glaucoma

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Expression for genes affiliated with Primary Open Angle Glaucoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Open Angle Glaucoma

Search GEO for disease gene expression data for Primary Open Angle Glaucoma.

Pathways for genes affiliated with Primary Open Angle Glaucoma

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 51QIAGEN
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Pathways related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6TGFB2, ELN, LOXL1
2
Hide members
10.5GSTM1, CYP1B1
3
Hide members
10.5TGFB2, ELN
4
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10.5TGFB2, ELN

Compounds for genes affiliated with Primary Open Angle Glaucoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2412.9TGFB2, ELN, GSTM1, ABCA4, RHO
2valine4410.9ELN, GSTM1, CYP1B1, RHO
3ozone4410.8GSTM1, ELN, TGFB2
4cysteine4410.8COCH, RHO, MYOC, GSTM1, ELN, TGFB2
5benzo(a)pyrene4410.8CYP1B1, GSTM1, TGFB2
6betacarotene4410.8ELN, GSTM1, RHO
7ascorbic acid44 2411.8MYOC, GSTM1, ELN, TGFB2
8pyrene4410.8GSTM1, CYP1B1
91-hydroxypyrene4410.7GSTM1, CYP1B1
1011-cis-retinol44 2411.6RHO, ABCA4
11glycosaminoglycan4410.6TGFB2, ELN, MYOC
12p0034410.6CYP1B1, GSTM1, TGFB2
13phip4410.5GSTM1, CYP1B1
14dexamethasone44 49 28 1113.5TGFB2, ELN, CYP1B1, MYOC, OPTN
15arginine4410.3RHO, NTF4, MYOC, GSTM1, ELN

GO Terms for genes affiliated with Primary Open Angle Glaucoma

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16Gene Ontology
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Cellular components related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:09738110.5ABCA4, RHO

Biological processes related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760110.6ABCA4, CYP1B1, WDR36, RHO

Products for genes affiliated with Primary Open Angle Glaucoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Primary Open Angle Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet