MCID: PRM010
MIFTS: 51

Primary Open Angle Glaucoma malady

Summaries for Primary Open Angle Glaucoma

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46OMIM, 32MalaCards
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MalaCards: Primary Open Angle Glaucoma, also known as primary open-angle glaucoma, is related to glaucoma and open-angle glaucoma. An important gene associated with Primary Open Angle Glaucoma is WDR36 (WD repeat domain 36), and among its related pathways are Elastic fibre formation and Estrogen metabolism. The compounds vitamin a and valine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotype vision/eye.

Description from OMIM:46 137760

Aliases & Classifications for Primary Open Angle Glaucoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 20GeneTests, 22GTR, 56SNOMED-CT, 39NCIt, 46OMIM, 27ICD9CM
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Aliases & Descriptions:

primary open angle glaucoma 8 10 44 30 60
primary open-angle glaucoma 8 20 22
chronic simple glaucoma 8


External Ids:

Disease Ontology8 DOID:1070
NCIt39 C35394
SNOMED-CT56 155122001, 77075001
OMIM46 137760
ICD9CM27 365.11

Related Diseases for Primary Open Angle Glaucoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Glaucoma 1a, Primary Open Angle family:

primary open angle glaucoma Open-Angle Glaucoma
Primary Open Angle Glaucoma Juvenile Onset 1 Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, or Adult Onset
Glaucoma 1b, Primary Open Angle, Adult Onset Glaucoma 1c, Primary Open Angle
Glaucoma 1d, Primary Open Angle Glaucoma, Primary Open Angle, Juvenile-Onset, 2
Glaucoma 1, Open Angle, P Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, 1o Glaucoma 1k, Primary Open Angle, Juvenile-Onset

Diseases related to Primary Open Angle Glaucoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma32.5TGFB2, ELN, CYP1B1, MYOC, NTF4, WDR36
2open-angle glaucoma32.5LOXL1, TGFB2, ELN, GSTM1, CYP1B1, MYOC
3ocular hypertension31.7OPTN, MYOC
4primary angle-closure glaucoma31.4MYOC
5retinitis31.3RHO
6cataract31.0RHO, MYOC, TGFB2
7exfoliation syndrome30.9ELN, LOXL1
8primary congenital glaucoma30.7CYP1B1
9primary open angle glaucoma juvenile onset 130.7MYOC, CYP1B1
10age related macular degeneration30.4RHO
11hypertension11.2
12juvenile glaucoma10.9
13myopia10.7
14low tension glaucoma10.6
15glaucoma 1, open angle, e10.5
16choroiditis10.4
17glaucomatocyclitic crisis10.4
18kearns-sayre syndrome10.4
19neuropathy10.4
20retinal vein occlusion10.4
21senile cataract10.4
22steroid-induced glaucoma - borderline10.3
23neovascular glaucoma10.3
24cycloplegia10.3
25cerebritis10.3
26exudative vitreoretinopathy10.3
27central retinal vein occlusion10.3
28alzheimer's disease10.3
29degenerative myopia10.3
30astigmatism10.3
31dementia10.3
32intracranial hypertension10.3
33keratoconus10.3
34migraine10.3
35mitochondrial encephalomyopathy10.3
36ocular hypotension10.3
37pancreatitis10.3
38pneumonia10.3
39refractive error10.3
40steroid-induced glaucoma10.3
41congenital stromal corneal dystrophy10.3
42glaucoma 1a, primary open angle10.3
43glaucoma 1c, primary open angle10.3
44glaucoma 1d, primary open angle10.3
45iridocyclitis10.1
46eye disease10.0OPTN, RHO, MYOC, ABCA4, TGFB2
47glaucoma 3, primary congenital, d10.0CYP1B1, MYOC, OPTN
48optic nerve disease10.0OPTN, MYOC, ELN
49blindness10.0OPTN, RHO, WDR36, MYOC, ABCA4
50peters plus syndrome10.0CYP1B1

Graphical network of the top 20 diseases related to Primary Open Angle Glaucoma:



Diseases related to primary open angle glaucoma

Clinical Features for Primary Open Angle Glaucoma

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Sources:
46OMIM
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Clinical features from OMIM:

137760

Drugs & Therapeutics for Primary Open Angle Glaucoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Primary Open Angle Glaucoma

Drug clinical trials:

Search ClinicalTrials for Primary Open Angle Glaucoma

Search NIH Clinical Center for Primary Open Angle Glaucoma

Search CenterWatch for Primary Open Angle Glaucoma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Primary Open Angle Glaucoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Primary Open Angle Glaucoma:
Renexus
Embryonic/Adult Cultured Cells Related to Primary Open Angle Glaucoma:
Human retinal stem cells secreting CNTF, PMIDs: 16805711, 17508034, 16505355, 23049090, 15684670, 12581701, 15223826, 18830926

Genetic Tests for Primary Open Angle Glaucoma

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Sources:
20GeneTests, 22GTR
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Genetic tests related to Primary Open Angle Glaucoma:

id Genetic test Affiliating Genes
1 Primary Open Angle Glaucoma (adult Onset)20 22 WDR36
2 Primary Open Angle Glaucoma22

Anatomical Context for Primary Open Angle Glaucoma

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32MalaCards
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MalaCards organs/tissues related to Primary Open Angle Glaucoma:

32
Eye, Testes, Endothelial, Brain, Retina, Cortex

Animal Models for Primary Open Angle Glaucoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Primary Open Angle Glaucoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.6TGFB2, ABCA4, CYP1B1, MYOC, RHO, ATOH7

Publications for Primary Open Angle Glaucoma

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50PubMed
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Articles related to Primary Open Angle Glaucoma:

(show top 50)    (show all 745)
idTitleAuthorsYear
1
Intraocular Pressure Fluctuation in Patients With Primary Open-angle Glaucoma Combined With High Myopia. (22668981)
2014
2
Predictive genetic testing experience for myocilin primary open-angle glaucoma using the Australian and New Zealand Registry of Advanced Glaucoma. (24406458)
2014
3
A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident primary open-angle glaucoma. (23412091)
2013
4
Neurodegenerative Genes Polymorphisms of the -491A/T APOE, the -877T/C APP and the Risk of Primary Open-angle Glaucoma in the Polish Population. (24073598)
2013
5
Spectral-domain optical coherence tomographic assessment of Schlemm's canal in Chinese subjects with primary open-angle glaucoma. (23352198)
2013
6
Clinical and morphological evaluation of gold micro shunt after unsuccessful surgical treatment of patients with primary open-angle glaucoma. (23867717)
2013
7
Association of the 399Arg/Gln XRCC1, the 194 Arg/Trp XRCC1, the 326Ser/Cys OGG1, and the 324Gln/His MUTYH gene polymorphisms with clinical parameters and the risk for development of primary open-angle glaucoma. (23499241)
2013
8
Are glutathione S-transferase polymorphisms (GSTM1, GSTT1) associated with primary open angle glaucoma? A meta-analysis. (23827458)
2013
9
Low-dose transscleral diode laser cyclophotocoagulation (TSCPC) as a potential single treatment for primary open-angle glaucoma (POAG) in Malawi? (23963489)
2013
10
The central corneal thickness in normal tension glaucoma, primary open angle glaucoma and ocular hypertension. (23905104)
2013
11
Hyaluronic acid increases MMP-2 and MMP-9 expressions in cultured trabecular meshwork cells from patients with primary open-angle glaucoma. (22605928)
2012
12
Multicenter, prospective, open-label, observational study of bimatoprost 0.01% in patients with primary open-angle glaucoma or ocular hypertension. (22654501)
2012
13
Effects of the time of antihypertensive drugs administration on the stage of primary open-angle glaucoma in patients with arterial hypertension. (22424547)
2012
14
Comparative study of the retinal nerve fibre layer thickness performed with optical coherence tomography and GDx scanning laser polarimetry in patients with primary open-angle glaucoma. (22367131)
2012
15
Association of Toll-like receptor 4 gene polymorphisms in Japanese subjects with primary open-angle, normal-tension, and exfoliation glaucoma. (22831837)
2012
16
Polymorphism in the TNF-I+(-863) locus associated with reduced risk of primary open angle glaucoma. (22509108)
2012
17
There is insufficient evidence to recommend lens extraction as a treatment for primary open-angle glaucoma: an evidence-based perspective. (21668783)
2012
18
A 4-week, dose-ranging study comparing the efficacy, safety and tolerability of latanoprost 75, 100 and 125 I1g/mL to latanoprost 50 I1g/mL (xalatan) in the treatment of primary open-angle glaucoma and ocular hypertension. (22607109)
2012
19
Serum levels and H/L gene polymorphism of mannose-binding lectin in primary open angle glaucoma. (22335808)
2012
20
A Joint Model for Prognostic Effect of Biomarker Variability on Outcomes: long-term intraocular pressure (IOP) fluctuation on the risk of developing primary open-angle glaucoma (POAG). (22180704)
2011
21
The influence of surgical and medical interventions upon optic disc structure in patients with primary open angle glaucoma. (22187300)
2011
22
Long-term outcomes of prostaglandin analog versus timolol maleate in ocular hypertensive or primary open-angle glaucoma patients in Europe. (21790326)
2011
23
Genes of the unfolded protein response pathway harbor risk alleles for primary open angle glaucoma. (21655191)
2011
24
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA. (21873608)
2011
25
Retinal nerve fiber layer defect patterns in primary angle-closure and open-angle glaucoma: a comparison using optical coherence tomography. (21331689)
2011
26
Clinical profiles of primary open angle glaucoma versus normal tension glaucoma patients: a pilot study. (21501076)
2011
27
Rigidity of retinal vessel in untreated eyes of normal tension primary open-angle glaucoma patients. (20577102)
2011
28
Rehabilitation of vision disorder and improved quality of life in patients with primary open angle glaucoma. (22040425)
2011
29
Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma. (20673200)
2010
30
Comparison of the diagnostic ability of Moorfield's regression analysis and glaucoma probability score using Heidelberg retinal tomograph III in eyes with primary open angle glaucoma. (20952832)
2010
31
Evaluation of SPARC as a candidate gene of juvenile-onset primary open-angle glaucoma by mutation and copy number analyses. (21042566)
2010
32
Ocular blood flow and oxygen delivery to the retina in primary open-angle glaucoma patients: the addition of dorzolamide to timolol monotherapy. (19706018)
2010
33
Understanding the mechanism of the water drinking test: the role of fluid challenge volume in patients with medically controlled primary open angle glaucoma. (20447094)
2010
34
Erythropoietin and soluble CD44 levels in patients with primary open-angle glaucoma. (20456444)
2010
35
Red blood cell plasmalogens and docosahexaenoic acid are independently reduced in primary open-angle glaucoma. (19627986)
2009
36
Comparing glaucomatous optic neuropathy in primary open angle and primary angle closure glaucoma eyes by scanning laser polarimetry-variable corneal compensation. (18344755)
2008
37
Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open angle glaucoma (POAG). (17242676)
2007
38
Identification and functional characterization of a novel MYOC mutation in two primary open angle glaucoma families from The Netherlands. (17960117)
2007
39
A new locus (GLC1H) for adult-onset primary open-angle glaucoma maps to the 2p15-p16 region. (17210857)
2007
40
Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost in patients with primary open angle glaucoma or ocular hypertension. (16488953)
2006
41
Distribution of oxidation enzyme eNOS and myeloperoxidase in primary open angle glaucoma. (15756709)
2005
42
Association of a common coding polymorphism (N453S) of the cytochrome P450 1B1 (CYP1B1) gene with optic disc cupping and visual field alteration in French patients with primary open-angle glaucoma. (16319821)
2005
43
A polymorphism at codon 31 of gene p21 is not associated with primary open angle glaucoma in Caucasians. (15807891)
2005
44
C677T variant in the methylentetrahydrofolate reductase gene is a genetic risk factor for primary open-angle glaucoma. (15808177)
2005
45
Decreased response of plasma cortisol to intravenous metyrapone in ocular hypertension and primary open-angle glaucoma. (16276280)
2005
46
The role of apolipoprotein E gene polymorphisms in primary open-angle glaucoma. (14769603)
2004
47
Genetic and environmental risk factors for primary open-angle glaucoma. (15161538)
2004
48
Genomic organization of the human myocilin gene (MYOC) responsible for primary open angle glaucoma (GLC1A). (9446806)
1998
49
Gln368STOP myocilin mutation in families with late-onset primary open-angle glaucoma. (9804137)
1998
50
Mutations in the TIGR gene in familial primary open-angle glaucoma in Japan. (9345106)
1997

Genetic Variations for Primary Open Angle Glaucoma

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Expression for genes affiliated with Primary Open Angle Glaucoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Open Angle Glaucoma

Search GEO for disease gene expression data for Primary Open Angle Glaucoma.

Pathways for genes affiliated with Primary Open Angle Glaucoma

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53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 51QIAGEN
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Pathways related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6TGFB2, ELN, LOXL1
2
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10.5GSTM1, CYP1B1
3
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10.5TGFB2, ELN
4
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10.5TGFB2, ELN

Compounds for genes affiliated with Primary Open Angle Glaucoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2412.9TGFB2, ELN, GSTM1, ABCA4, RHO
2valine4410.9ELN, GSTM1, CYP1B1, RHO
3ozone4410.8GSTM1, ELN, TGFB2
4cysteine4410.8COCH, RHO, MYOC, GSTM1, ELN, TGFB2
5benzo(a)pyrene4410.8CYP1B1, GSTM1, TGFB2
6betacarotene4410.8ELN, GSTM1, RHO
7ascorbic acid44 2411.8MYOC, GSTM1, ELN, TGFB2
8pyrene4410.8GSTM1, CYP1B1
91-hydroxypyrene4410.7GSTM1, CYP1B1
1011-cis-retinol44 2411.6RHO, ABCA4
11glycosaminoglycan4410.6TGFB2, ELN, MYOC
12p0034410.6CYP1B1, GSTM1, TGFB2
13phip4410.5GSTM1, CYP1B1
14dexamethasone44 49 28 1113.5TGFB2, ELN, CYP1B1, MYOC, OPTN
15arginine4410.3RHO, NTF4, MYOC, GSTM1, ELN

GO Terms for genes affiliated with Primary Open Angle Glaucoma

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16Gene Ontology
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Cellular components related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor disc membraneGO:09738110.5ABCA4, RHO

Biological processes related to Primary Open Angle Glaucoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760110.6ABCA4, CYP1B1, WDR36, RHO

Products for genes affiliated with Primary Open Angle Glaucoma

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  • Antibodies
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  • Antibodies

Sources for Primary Open Angle Glaucoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet