PPC
MCID: PRM126
MIFTS: 47

Primary Peritoneal Carcinoma (PPC) malady

Cancer diseases category

Summaries for Primary Peritoneal Carcinoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Primary peritoneal cancer or carcinoma is also known as: serous surface papillary carcinoma, primary... more...

MalaCards: Primary Peritoneal Carcinoma, also known as serous surface papillary carcinoma, is related to peritonitis and papillary carcinoma, and has symptoms including early death/lethality, weight loss/loss of appetite/break in weight curve/general health alteration and ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma). An important gene associated with Primary Peritoneal Carcinoma is BRCA1 (breast cancer 1, early onset), and among its related pathways are TGF-Beta Pathway and Nucleotide Excision Repair. The compounds cycloheximide and resveratrol have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Classifications for Primary Peritoneal Carcinoma

About this section
Sources:
48Orphanet, 60UMLS, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
serous surface papillary carcinoma:
Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

primary peritoneal carcinoma 48 60
serous surface papillary carcinoma 48 60
extra-ovarian primary peritoneal carcinoma 48
primary peritoneal serous carcinoma 48
eoppc 48
ppc 48


External Ids:

ICD10 via Orphanet26 C48.2

Related Diseases for Primary Peritoneal Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Primary Peritoneal Carcinoma family:

Peritoneal Benign Neoplasm Peritoneal Carcinoma

Diseases related to Primary Peritoneal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 186)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.6MUC16
2papillary carcinoma30.8MUC16, BRCA2, ERBB2, PGR, RET
3ovarian cancer30.6BRCA1, BRCA2, CEACAM5, TP53, ERBB2, ERCC1
4adenocarcinoma30.4ERBB2, CEACAM5, BRCA1, TP53, ERCC1, CXCL10
5hepatitis30.3CXCL10
6tuberculosis30.3IFNG, CXCL10, IL10
7cervical adenocarcinoma30.1PGR, CEACAM5, MUC16
8endometriosis30.1MUC16, PGR, IL8
9peritoneal carcinoma29.9BRCA2, BRCA1
10ovary papillary carcinoma10.5
11papillary serous adenocarcinoma10.4
12ovarian disease10.3
13primary syphilis10.2
14in situ carcinoma10.2
15syphilis10.2
16tertiary syphilis10.2
17eye carcinoma10.1
18choroiditis10.1
19pleomorphic carcinoma10.1
20lymphangitis10.1
21breast disease10.1
22cervicitis10.1
23trophoblastic neoplasm10.1
24herpes simplex10.0CXCL10
25colon adenocarcinoma10.0CEACAM5
26biliary atresia10.0CXCL10
27arthropathy10.0CXCL10
28severe acute respiratory syndrome10.0CXCL10
29cystadenoma10.0BRCA1
30mycosis fungoides10.0CXCL10
31wilms tumor10.0BRCA2
32breast-ovarian cancer, familial, 210.0BRCA2
33pleurisy10.0MUC16
34dermatomyositis10.0MUC16
35neurofibromatosis10.0RET
36hemangioma10.0RET
37leiomyoma10.0PGR
38meningioma10.0PGR
39von hippel-lindau disease10.0RET
40angiomyolipoma10.0PGR
41parathyroid carcinoma10.0RET
42hyperparathyroidism10.0RET
43peutz-jeghers syndrome10.0BRCA2
44uterine carcinosarcoma10.0ERBB2
45anaplastic large cell lymphoma10.0MUC16
46dementia10.0CXCL10
47posterior polar cataract10.0
48cataract10.0
49malaria10.0
50pneumothorax10.0

Graphical network of the top 20 diseases related to Primary Peritoneal Carcinoma:



Diseases related to primary peritoneal carcinoma

Clinical Features for Primary Peritoneal Carcinoma

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 9)
  • early death/lethality
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • neoplasms/tumors
  • peritoneal diseases
  • constipation
  • acute abdominal pain/colic
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • anomalies of the abdominal wall

Drugs & Therapeutics for Primary Peritoneal Carcinoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Primary Peritoneal Carcinoma

Drug clinical trials:

Search ClinicalTrials for Primary Peritoneal Carcinoma

Search NIH Clinical Center for Primary Peritoneal Carcinoma

Search CenterWatch for Primary Peritoneal Carcinoma

Genetic Tests for Primary Peritoneal Carcinoma

About this section

Anatomical Context for Primary Peritoneal Carcinoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Primary Peritoneal Carcinoma:

32
Ovary

Animal Models for Primary Peritoneal Carcinoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Primary Peritoneal Carcinoma:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.5BRCA2
2MP:000539010.0BRCA1, BRCA2, PGR
3MP:00053699.8RET, TP53
4MP:00036319.7RET, ERBB2
5MP:00107719.6BRCA1, BRCA2, ERCC1, TP53
6MP:00053809.4RET, PGR, IL10, ERBB2
7MP:00053889.3BRCA1, EGFR, ERBB2, TP53
8MP:00053799.1BRCA1, BRCA2, IFNG, RET, TP53
9MP:00053679.1BRCA1, EGFR, RET
10MP:00053768.8BRCA1, BRCA2, IFNG, RET, PGR, CXCL10
11MP:00020068.7ERBB2, IL10, PGR, RET, EGFR, IFNG
12MP:00053898.5BRCA1, BRCA2, EGFR, RET, ERCC1, ERBB2
13MP:00030128.2TP53, IL10, PGR, RET, EGFR, IFNG
14MP:00053818.0BRCA1, BRCA2, IFNG, EGFR, RET, IL10
15MP:00028737.7BRCA1, BRCA2, IFNG, EGFR, RET, PGR
16MP:00053857.7BRCA1, IFNG, EGFR, RET, PGR, CXCL10
17MP:00053867.7BRCA1, BRCA2, IFNG, RET, PGR, IL10
18MP:00053787.4BRCA1, BRCA2, IFNG, EGFR, RET, IL10
19MP:00053977.3BRCA1, BRCA2, IFNG, EGFR, RET, PGR
20MP:00053877.3BRCA1, BRCA2, IFNG, EGFR, RET, PGR
21MP:00053847.3BRCA1, BRCA2, IFNG, EGFR, RET, PGR
22MP:00107687.2BRCA1, BRCA2, IFNG, EGFR, RET, PGR

Publications for Primary Peritoneal Carcinoma

About this section

Genetic Variations for Primary Peritoneal Carcinoma

About this section

Expression for genes affiliated with Primary Peritoneal Carcinoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Primary Peritoneal Carcinoma

Search GEO for disease gene expression data for Primary Peritoneal Carcinoma.

Pathways for genes affiliated with Primary Peritoneal Carcinoma

About this section
Sources:
51QIAGEN, 53Reactome, 12EMD Millipore, 59Tocris Bioscience, 37NCBI BioSystems Database, 29KEGG, 55SinoBiological, 52R&D Systems, 49PharmGKB
See all sources

Pathways related to Primary Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2ERBB2
2
Hide members
10.0BRCA2, ERCC1
39.8TP53, BRCA1
4
Hide members
9.8TP53, ERBB2
59.8IL8, TP53
69.8ERCC1, BRCA2, BRCA1
79.6IL8, IFNG, BRCA1
8
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
9.6BRCA1, BRCA2, TP53
99.6BRCA1, BRCA2, TP53
10
Hide members
9.6ERBB2, CXCL10, EGFR
119.5IFNG, IL10, IL8
129.5IL8, IL10, IFNG
139.5MIR195, MIR497
149.5ERBB2, EGFR, IFNG
159.5EGFR, CXCL10, TP53
169.4IFNG, IL8, TP53
17
Hide members
9.4IFNG, IL8, TP53
18
Hide members
9.4TP53, ERBB2, EGFR
199.4TP53, ERBB2, EGFR
209.4EGFR, ERBB2, TP53
21
Hide members
9.4EGFR, ERBB2, TP53
22
Hide members
9.3TP53, ERBB2, CXCL10, BRCA1
23
Hide members
9.3TP53, IL8, BRCA2, BRCA1
249.2TP53, EGFR, BRCA2, BRCA1
25
Hide members
9.2TP53, IL8, CXCL10, IFNG
26
Hide members
9.2EGFR, CXCL10, ERBB2, TP53
27
Hide members
9.2TP53, ERBB2, EGFR, BRCA2
28
Hide members
8.9BRCA1, BRCA2, EGFR, ERBB2, TP53
298.9TP53, ERBB2, EGFR, BRCA2, BRCA1
30
Hide members
8.9IFNG, CXCL10, IL10, IL8, TP53
318.7BRCA1, EGFR, MIR195, ERBB2, TP53
32
Hide members
8.6EGFR, CXCL10, IL10, IL8, ERBB2, TP53
338.3BRCA2, EGFR, RET, IL8, ERBB2, TP53

Compounds for genes affiliated with Primary Peritoneal Carcinoma

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Primary Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.2BRCA2, BRCA1, CXCL10
2resveratrol44 59 11 2413.0ERBB2, PGR, BRCA2
3adriamycin4410.0CEACAM5, PGR
4tamoxifen44 49 28 1112.9ERBB2, EGFR, PGR
5dexamethasone44 49 28 1112.9MUC16
6vinorelbine44 1110.7BRCA1, EGFR, ERBB2, ERCC1
7fluticasone propionate44 49 59 1112.7IL8, CXCL10, PGR, IFNG
8anastrozole44 1110.6EGFR, PGR, ERBB2
9polyinosinic-polycytidylic acid449.6IL8, IL10, CXCL10, IFNG
10capecitabine44 49 1111.6PGR, ERBB2, EGFR
11il 10449.5IL8, IL10, CXCL10, IFNG
12tarc449.5IFNG, CXCL10, IL10, IL8
13taxane449.5EGFR, TP53, ERBB2, PGR
14ccl344 2810.5IL10, CXCL10, IFNG, IL8
15neopterin449.4IL10, IFNG, CXCL10, IL8
16etoposide44 49 59 1112.4BRCA1, BRCA2, ERCC1, ERBB2
17hydrocortisone44 2 59 1112.4ERBB2, IL8, IL10, CXCL10, IFNG
18suberoylanilide hydroxamic acid449.3IFNG, TP53, EGFR, ERBB2
19bortezomib44 1110.3TP53, ERBB2, EGFR, BRCA1
20methotrexate44 49 1111.3BRCA1, ERBB2, ERCC1, IL10, PGR, BRCA2
21exemestane49 44 59 1112.3EGFR, PGR, ERBB2
22leucovorin44 49 1111.2PGR, EGFR, CEACAM5, ERBB2
23adpribose449.2BRCA2, EGFR, TP53, BRCA1
244-hydroxytamoxifen449.2EGFR, BRCA1, BRCA2, IFNG, PGR, ERBB2
25gemcitabine44 49 1111.0TP53, EGFR, IL10, ERCC1, ERBB2, BRCA1
26thymidylate449.0ERBB2, IL10, BRCA1, TP53, ERCC1, EGFR
27herbimycin a44 599.9EGFR, ERBB2, IL8, RET, IFNG
28irinotecan44 49 1110.9TP53, CEACAM5, EGFR, ERCC1, ERBB2
29gold448.9CEACAM5, CXCL10, MUC16, BRCA2
30docetaxel44 49 59 1111.9ERBB2, PGR, ERCC1, TP53, BRCA2, EGFR
31melphalan44 119.8TP53, MUC16, IFNG, ERCC1
32mitomycin c448.8TP53, CEACAM5, ERCC1, IL10, BRCA2, BRCA1
33topotecan44 119.8TP53, ERBB2, MUC16, EGFR, BRCA1
34oxaliplatin44 49 1110.8BRCA1, EGFR, ERCC1, ERBB2, CEACAM5, TP53
35agar448.6PGR, BRCA1, EGFR, RET, ERBB2, CEACAM5
36ly294002448.6EGFR, RET, IL10, IL8, ERBB2, TP53
37cyclophosphamide44 49 1110.3TP53, IL10, ERBB2, ERCC1, BRCA1, MUC16
38thymidine44 249.2TP53, CXCL10, IL10, ERCC1, BRCA2, CEACAM5
39carboplatin44 49 1110.2MUC16, ERCC1, ERBB2, TP53, EGFR, IFNG
40retinoic acid44 249.2RET, PGR, TP53, IFNG, BRCA1, EGFR
415fluorouracil448.2CEACAM5, IFNG, EGFR, PGR, BRCA1, ERCC1
42genistein44 28 59 2 11 2413.1PGR, ERBB2, CXCL10, IL8, RET, EGFR
43phosphatidylinositol448.1ERCC1, RET, EGFR, BRCA1, BRCA2, ERBB2
44paclitaxel44 49 1110.0ERBB2, ERCC1, PGR, MUC16, BRCA1, BRCA2
45testosterone44 59 11 2411.0ERBB2, BRCA1, BRCA2, EGFR, MUC16, RET
46doxorubicin44 49 119.7ERBB2, CEACAM5, ERCC1, MUC16, EGFR, BRCA1
47cisplatin44 49 59 1110.7TP53, CEACAM5, ERBB2, ERCC1, EGFR, BRCA2
48progesterone44 59 28 11 2411.4EGFR, MUC16, PGR, CXCL10, ERBB2, CEACAM5
49paraffin446.8CEACAM5, BRCA1, BRCA2, EGFR, MUC16, TP53
50vegf446.0EGFR, IL8, IL10, CXCL10, PGR, RET

GO Terms for genes affiliated with Primary Peritoneal Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Primary Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1IL8, IL10, CXCL10, MUC16, EGFR, IFNG

Biological processes related to Primary Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:0453489.9IFNG, IL10
2response to molecule of bacterial originGO:0022379.9IL8, IL10
3DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9BRCA1, BRCA2, TP53
4response to X-rayGO:0101659.8TP53, ERCC1, BRCA2
5response to gamma radiationGO:0103329.8BRCA2, CXCL10, TP53
6cellular response to estradiol stimulusGO:0713929.8IL10, EGFR
7nucleotide-excision repairGO:0062899.7BRCA2, ERCC1, TP53
8cellular response to lipopolysaccharideGO:0712229.7IFNG, IL10, IL8
9double-strand break repairGO:0063029.6TP53, ERCC1, BRCA2, BRCA1
10negative regulation of growth of symbiont in hostGO:0441309.5IL10, IFNG
11cell surface receptor signaling pathwayGO:0071669.5ERBB2, CXCL10, EGFR, IFNG
12cell proliferationGO:0082839.1EGFR, ERCC1, ERBB2, TP53
13positive regulation of transcription, DNA-dependentGO:0458939.0BRCA1, BRCA2, RET, IL10, TP53
14positive regulation of transcription from RNA polymerase II promoterGO:0459448.8BRCA1, IFNG, EGFR, IL10, TP53
15signal transductionGO:0071658.7EGFR, RET, PGR, CXCL10, IL8, ERBB2

Molecular functions related to Primary Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.9ERBB2, EGFR
2receptor signaling protein tyrosine kinase activityGO:0047169.7ERBB2, EGFR
3transmembrane receptor protein tyrosine kinase activityGO:0047149.4ERBB2, RET, EGFR
4enzyme bindingGO:0198999.2BRCA1, EGFR, PGR, TP53
5protein tyrosine kinase activityGO:0047139.0EGFR, RET, ERBB2
6protein bindingGO:0055156.5BRCA2, EGFR, MUC16, RET, PGR, CXCL10

Products for genes affiliated with Primary Peritoneal Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Primary Peritoneal Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet