PPC
MCID: PRM126
MIFTS: 59

Primary Peritoneal Carcinoma (PPC) malady

Cancer diseases, Rare diseases categories
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Summaries for Primary Peritoneal Carcinoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Primary peritoneal cancer or carcinoma is also known as: serous surface papillary carcinoma, primary... more...

MalaCards: Primary Peritoneal Carcinoma, also known as serous surface papillary carcinoma, is related to peritoneal carcinoma and papillary carcinoma, and has symptoms including peritoneal diseases, anomalies of the abdominal wall and ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma). An important gene associated with Primary Peritoneal Carcinoma is BRCA1 (breast cancer 1, early onset), and among its related pathways are Homologous Recombination Repair and DNA Damage Induced 14-3-3Sigma Signaling. The compounds topotecan and vinorelbine have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and breast, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Primary Peritoneal Carcinoma

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49Orphanet, 62UMLS, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
serous surface papillary carcinoma:
Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

primary peritoneal carcinoma 49 62
serous surface papillary carcinoma 49 62
extra-ovarian primary peritoneal carcinoma 49
primary peritoneal serous carcinoma 49
eoppc 49
ppc 49


External Ids:

ICD10 via Orphanet26 C48.2

Related Diseases for Primary Peritoneal Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Primary Peritoneal Carcinoma family:

Peritoneal Benign Neoplasm Peritoneal Carcinoma

Diseases related to Primary Peritoneal Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1peritoneal carcinoma31.8BRCA1, BRCA2
2papillary carcinoma30.9BRCA2, PGR, MUC16, RET, ERBB2
3ovarian cancer30.5TP53, BRCA2, BRCA1, PGR, MUC16, ERBB2
4tuberculosis30.4IL10, IFNG, CXCL10
5endometriosis30.2PGR, MUC16, IL8
6adenocarcinoma30.2TP53, BRCA2, BRCA1, PGR, MUC16, CXCL10
7peritonitis11.1
8papillary serous adenocarcinoma10.5
9ovary papillary carcinoma10.3
10hepatitis10.3
11in situ carcinoma10.3
12syphilis10.3
13tertiary syphilis10.3
14struma ovarii10.1MUC16
15adenofibroma10.1MUC16
16breast-ovarian cancer, familial, 210.1BRCA2
17ovarian serous cystadenocarcinoma10.1MUC16
18pleurisy10.1MUC16
19cystadenoma10.1BRCA1
20uterine fibroid10.1PGR
21cystadenocarcinoma10.1CEACAM5, MUC16
22lymphangitis10.1
23choroiditis10.1
24cervicitis10.1
25paraneoplastic syndromes10.1
26endotheliitis10.1
27intestinal lymphangiectasia10.1
28papillary adenocarcinoma10.1MUC16, CEACAM5
29brca1 and brca2 hereditary breast and ovarian cancer10.1BRCA2, BRCA1
30endodermal sinus tumor10.1MUC16, CEACAM5
31fallopian tube cancer10.1BRCA2, BRCA1
32breast cancer10.1BRCA2, BRCA1
33neuroblastoma10.1TP53
34ovarian cystadenoma10.1BRCA1, MUC16
35lynch syndrome10.1BRCA2, BRCA1
36paracoccidioidomycosis10.1CXCL10, IL10
37meningitis10.1IL8, CXCL10
38dysgerminoma10.1BRCA1, BRCA2
39sex cord-gonadal stromal tumor10.1CEACAM5, PGR
40autosomal dominant disease10.1BRCA1, RET
41viral meningitis10.1CXCL10, IL8
42mammary paget's disease10.1PGR, ERBB2
43bronchiolitis obliterans10.1CXCL10, IL8
44li-fraumeni syndrome10.1PGR, ERBB2
45cervical adenocarcinoma10.1PGR, MUC16, CEACAM5
46folliculitis10.1EGFR
47familial colorectal cancer10.1BRCA2, BRCA1, RET
48cowden disease10.1RET, BRCA1, BRCA2
49bilateral breast cancer10.1BRCA2, BRCA1, PGR
50gynecomastia10.1PGR, BRCA1, BRCA2

Graphical network of the top 20 diseases related to Primary Peritoneal Carcinoma:



Diseases related to primary peritoneal carcinoma

Symptoms for Primary Peritoneal Carcinoma

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49Orphanet
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Symptoms:

49 (show all 9)
  • peritoneal diseases
  • anomalies of the abdominal wall
  • ovary/fallopian tube neoplasm/tumor/carcinoma/cancer (excl. teratoma/germinoma)
  • neoplasms/tumors
  • acute abdominal pain/colic
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • early death/lethality
  • constipation
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Primary Peritoneal Carcinoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Primary Peritoneal Carcinoma

Search NIH Clinical Center for Primary Peritoneal Carcinoma

Genetic Tests for Primary Peritoneal Carcinoma

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Anatomical Context for Primary Peritoneal Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Primary Peritoneal Carcinoma:

33
Ovary, Endothelial, Breast, Testes, Eye, Lymph node, Brain

Animal Models for Primary Peritoneal Carcinoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Primary Peritoneal Carcinoma:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7EGFR, ERCC1, IL10, IFNG, TP53
2MP:00053678.5TP53, BRCA1, RET, IFNG, ERCC1, EGFR
3MP:00053828.3TP53, IFNG, IL10, ERBB2, EGFR
4MP:00053718.3TP53, BRCA2, BRCA1, PGR, RET, IL10
5MP:00053888.3TP53, BRCA1, RET, IFNG, IL10, ERBB2
6MP:00030128.3TP53, PGR, RET, IFNG, IL10, EGFR
7MP:00053818.1TP53, BRCA2, BRCA1, RET, IFNG, IL10
8MP:00053697.9TP53, BRCA1, PGR, RET, IFNG, IL10
9MP:00053867.9TP53, BRCA2, BRCA1, PGR, RET, IFNG
10MP:00053907.9TP53, BRCA2, BRCA1, PGR, IFNG, IL10
11MP:00107717.9TP53, BRCA2, BRCA1, PGR, IFNG, IL10
12MP:00028737.9TP53, BRCA2, BRCA1, PGR, RET, IFNG
13MP:00053857.8TP53, BRCA1, PGR, CXCL10, RET, IFNG
14MP:00036317.8TP53, BRCA2, BRCA1, CXCL10, RET, IFNG
15MP:00020067.7EGFR, TP53, BRCA2, BRCA1, PGR, RET
16MP:00053797.7TP53, BRCA2, BRCA1, PGR, RET, IFNG
17MP:00053807.7PGR, BRCA1, BRCA2, TP53, RET, IFNG
18MP:00053787.7TP53, BRCA2, BRCA1, RET, IFNG, IL10
19MP:00053897.7PGR, BRCA1, BRCA2, TP53, RET, IFNG
20MP:00053847.4PGR, BRCA1, BRCA2, TP53, CXCL10, RET
21MP:00053977.4PGR, BRCA1, BRCA2, TP53, CXCL10, RET
22MP:00053877.4TP53, BRCA2, BRCA1, PGR, CXCL10, RET
23MP:00053767.4TP53, BRCA2, BRCA1, PGR, CXCL10, RET
24MP:00107687.3TP53, BRCA2, BRCA1, PGR, CXCL10, RET

Publications for Primary Peritoneal Carcinoma

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52PubMed
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Articles related to Primary Peritoneal Carcinoma:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma. (24073344)
2013
2
Upper abdominal procedures in advanced stage ovarian or primary peritoneal carcinoma patients with minimal or no gross residual disease: an analysis of Gynecologic Oncology Group (GOG) 182. (23791702)
2013
3
The effect of age on first-line chemotherapy for epithelial ovarian cancer and primary peritoneal carcinoma. (23146339)
2013
4
A phase II evaluation of AMG 102 (rilotumumab) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma: A Gynecologic Oncology Group study. (24361733)
2013
5
A case of extraovarian primary peritoneal carcinoma in an oophorectomized-hysterectomized patient: a diagnostic dilemma. (23578412)
2013
6
Phase II evaluation of dasatinib in the treatment of recurrent or persistent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study. (22710075)
2012
7
A phase II study of a urokinase-derived peptide (A6) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma: a Gynecologic Oncology Group study. (22446624)
2012
8
A phase II evaluation of lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a gynecologic oncology group study. (22037316)
2012
9
Prognosis of primary peritoneal carcinoma: effect of cytoreductive surgery combined with neoadjuvant chemotherapy after laparoscopic diagnosis and evaluation: a multi-center trial. (22439406)
2012
10
A phase I study with an expanded cohort to assess feasibility of intravenous docetaxel, intraperitoneal carboplatin and intraperitoneal paclitaxel in patients with previously untreated ovarian, fallopian tube or primary peritoneal carcinoma: a Gynecologic Oncology Group study. (22943879)
2012
11
Pax-8 is a reliable marker in making the diagnosis in advanced stage epithelial ovarian carcinoma and primary peritoneal carcinoma for neoadjuvant chemotherapy on cell block and biopsy specimens. (22348438)
2012
12
Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. (22772063)
2012
13
A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma. (22047770)
2012
14
A phase I study with an expanded cohort to assess the feasibility of intravenous paclitaxel, intraperitoneal carboplatin and intraperitoneal paclitaxel in patients with untreated ovarian, fallopian tube or primary peritoneal carcinoma: a Gynecologic Oncology Group study. (22155262)
2012
15
Primary peritoneal carcinoma in complete remission: a case report. (22199305)
2011
16
A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: an NCIC Clinical Trials Group Study. (20705911)
2011
17
Peritoneal tuberculosis: a retrospective review of 20 cases and comparison with primary peritoneal carcinoma. (20973271)
2010
18
Randomized phase III trial of tamoxifen versus thalidomide in women with biochemical-recurrent-only epithelial ovarian, fallopian tube or primary peritoneal carcinoma after a complete response to first-line platinum/taxane chemotherapy with an evaluation of serum vascular endothelial growth factor (VEGF): A Gynecologic Oncology Group Study. (20846715)
2010
19
The utility and cost of routine follow-up procedures in the surveillance of ovarian and primary peritoneal carcinoma: a 16-year institutional review. (21045830)
2010
20
Phase II trial of single agent cetuximab in patients with persistent or recurrent epithelial ovarian or primary peritoneal carcinoma with the potential for dose escalation to rash. (19162309)
2009
21
RET/PTC rearrangement occurring in primary peritoneal carcinoma. (19147513)
2009
22
Primary peritoneal carcinoma in a young woman with suspected endometriosis. (19327764)
2009
23
Choroidal eye metastases from (recurrent) primary peritoneal carcinoma: case report and review of the literature. (19154601)
2009
24
Primary peritoneal carcinoma: computed tomography and magnetic resonance findings. (18664839)
2008
25
Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses. (18543395)
2008
26
A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study. (18295319)
2008
27
Safety and efficacy of lenalidomide (Revlimid) in recurrent ovarian and primary peritoneal carcinoma. (17257661)
2007
28
Colorectal resection in patients with ovarian and primary peritoneal carcinoma. (16730631)
2006
29
Primary peritoneal carcinoma in a UK cancer center: comparison with advanced ovarian carcinoma over a 5-year period. (16515579)
2006
30
Primary peritoneal carcinoma: a rare neoplasm with pleomorphic trophoblastic morphology. (16907865)
2006
31
Negative laparoscopy is highly predictive of negative second-look laparotomy following chemotherapy for ovarian, tubal, and primary peritoneal carcinoma. (16769104)
2006
32
Asymptomatic primary peritoneal carcinoma presenting as adenocarcinoma on routine cervical cytology. (16553187)
2006
33
Follow-up of ovarian and primary peritoneal carcinoma: the value of physical examination in patients with pretreatment elevated CA125 levels. (16564077)
2006
34
Phase II evaluation of 9-aminocamptothecin (9-AC, NSC #603071) in platinum-resistant ovarian and primary peritoneal carcinoma: a Gynecologic Oncology Group Study. (15589582)
2005
35
Is semen an etiologic factor in the development of primary peritoneal carcinoma and epithelial ovarian cancer? (15607552)
2005
36
Phase II study of CT-2103 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. (15542803)
2004
37
Primary peritoneal carcinoma. (15559336)
2004
38
Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations. (14615451)
2003
39
Axillary lymphadenopathy as the primary presentation of primary peritoneal carcinoma. (12592068)
2002
40
Prolonged symptom-free survival in a patient with persistent primary peritoneal carcinoma and a rising CA-125: a note of caution. (11371148)
2001
41
Extreme drug resistance assay and response to chemotherapy in patients with primary peritoneal carcinoma. (10738268)
2000
42
Importance of lymph node metastases in primary peritoneal carcinoma. (9701204)
1998
43
Evidence that a "treatment-free interval of less than 6 months" does not equate with clinically defined platinum resistance in ovarian cancer or primary peritoneal carcinoma. (9692840)
1998
44
Extraovarian primary peritoneal carcinoma. (9644683)
1998
45
Prognostic factors in extraovarian primary peritoneal carcinoma. (9826465)
1998
46
Primary peritoneal carcinoma can have multifocal origins: implications for prophylactic oophorectomy. (9625162)
1998
47
Two sequential studies for primary peritoneal carcinoma: induction with weekly cisplatin followed by either cisplatin-doxorubicin-cyclophosphamide or paclitaxel-cisplatin. (9367697)
1997
48
Primary peritoneal carcinoma: a treatable subset of patients with adenocarcinoma of unknown primary. (8602811)
1996
49
Surgically documented responses to paclitaxel and cisplatin in patients with primary peritoneal carcinoma. (8690292)
1996
50
Primary peritoneal carcinoma after prophylactic oophorectomy in women with a family history of ovarian cancer. A report of the Gilda Radner Familial Ovarian Cancer Registry. (8467455)
1993

Variations for Primary Peritoneal Carcinoma

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Expression for genes affiliated with Primary Peritoneal Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Peritoneal Carcinoma

Search GEO for disease gene expression data for Primary Peritoneal Carcinoma.

Pathways for genes affiliated with Primary Peritoneal Carcinoma

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Sources:
50PathCards, 55Reactome, 53QIAGEN, 60Thomson Reuters, 30KEGG, 38NCBI BioSystems Database, 5Cell Signaling Technology, 54R&D Systems, 61Tocris Bioscience, 57SinoBiological, 51PharmGKB
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Pathways related to Primary Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0BRCA1, BRCA2
29.8BRCA1, TP53
39.8BRCA1, TP53
49.8IL10, IFNG
59.7ERCC1, BRCA1, BRCA2
6
Show member pathways
9.7BRCA2, BRCA1, ERCC1
79.7EGFR, IL8
89.6RET, IL10, IL8
99.5BRCA1, IFNG, IL8
10
Show member pathways
9.5BRCA1, BRCA2, TP53
119.5TP53, BRCA2, BRCA1
12
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5IL8, IFNG, CXCL10
13
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.5RET, ERBB2, EGFR
149.5RET, ERBB2, EGFR
159.4IL8, IL10, IFNG
169.4IFNG, IL10, IL8
179.4IFNG, IL10, IL8
189.4IFNG, ERBB2, EGFR
199.3EGFR, ERBB2, TP53
20
Show member pathways
9.3TP53, ERBB2, EGFR
21
Show member pathways
Signal transduction PTEN pathway60
9.3EGFR, ERBB2, TP53
229.3TP53, ERBB2, EGFR
23
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.3EGFR, ERBB2, TP53
24
Show member pathways
9.3TP53, ERBB2, EGFR
259.3IL8, IFNG, TP53
269.3IL8, IFNG, TP53
27
Show member pathways
Immune response MIF in innate immunity response60
9.3IL8, IFNG, TP53
28
Show member pathways
9.3ERCC1, BRCA1, BRCA2, TP53
29
Show member pathways
9.3ERCC1, BRCA1, BRCA2, TP53
309.3EGFR, IL8, TP53
31
Show member pathways
9.2TP53, IFNG, EGFR
329.2TP53, IFNG, EGFR
339.1TP53, BRCA2, BRCA1, EGFR
34
Show member pathways
9.1TP53, CXCL10, IFNG, IL8
35
Show member pathways
9.0EGFR, ERBB2, BRCA2, TP53
36
Show member pathways
8.9TP53, IFNG, ERBB2, EGFR
378.9TP53, MIR497, MIR195
38
Show member pathways
8.9EGFR, ERBB2, IL8, IL10, CXCL10
39
Show member pathways
8.8TP53, BRCA2, BRCA1, ERBB2, EGFR
408.8TP53, BRCA2, BRCA1, ERBB2, EGFR
41
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.7TP53, CXCL10, IFNG, IL10, IL8
428.7TP53, CXCL10, IFNG, IL8, EGFR
43
Show member pathways
Signaling Pathways in Glioblastoma38
8.5EGFR, ERBB2, IL8, BRCA1, BRCA2, TP53
448.5TP53, BRCA1, MIR195, ERBB2, EGFR
45
Show member pathways
8.5TP53, PGR, CXCL10, IL8, ERBB2, EGFR
468.4TP53, BRCA2, RET, IL8, ERBB2, EGFR
47
Show member pathways
8.4TP53, CXCL10, IL10, IL8, ERBB2, EGFR
48
Show member pathways
8.2TP53, BRCA1, CXCL10, IL10, IL8, ERBB2
49
Show member pathways
8.0TP53, BRCA1, IFNG, IL10, IL8, ERBB2
50
Show member pathways
8.0TP53, CXCL10, IFNG, IL10, IL8, ERBB2

Compounds for genes affiliated with Primary Peritoneal Carcinoma

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 3BitterDB
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Compounds related to Primary Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 175)
idCompoundScoreTop Affiliating Genes
1topotecan45 1110.7EGFR, MUC16, BRCA1
2vinorelbine45 51 1111.7EGFR, ERCC1, ERBB2, BRCA1
3fluticasone propionate45 51 61 1112.5IFNG, IL8, CXCL10, PGR
4polyinosinic-polycytidylic acid459.5IL10, IFNG, CXCL10, IL8
5capecitabine45 51 1111.5EGFR, ERBB2, PGR
6il 10459.4CXCL10, IFNG, IL10, IL8
7tarc459.4IL8, IFNG, IL10, CXCL10
8taxane459.4EGFR, TP53, PGR, ERBB2
9ccl345 2910.4CXCL10, IFNG, IL10, IL8
10neopterin459.3IL8, IL10, CXCL10, IFNG
11resveratrol45 61 24 1112.3PGR, ERBB2, BRCA1, BRCA2, TP53
12hydrocortisone45 3 61 1112.2IL10, IFNG, ERBB2, IL8, CXCL10
13methotrexate51 45 1111.2IL10, PGR, ERBB2, BRCA2, BRCA1, ERCC1
14suberoylanilide hydroxamic acid459.2EGFR, ERBB2, IFNG, TP53
15bortezomib45 51 1111.2EGFR, BRCA1, ERBB2, TP53
16herbimycin a45 6110.1RET, IFNG, IL8, ERBB2, EGFR
174-hydroxytamoxifen459.0ERBB2, BRCA1, PGR, IFNG, BRCA2, EGFR
18melphalan45 51 1111.0ERCC1, TP53, MUC16, IFNG
19etoposide45 51 61 1112.0BRCA2, ERCC1, ERBB2, BRCA1, TP53
20gemcitabine45 51 1110.9IL10, ERBB2, TP53, ERCC1, EGFR, BRCA1
21thymidylate458.9TP53, BRCA1, IL10, ERBB2, ERCC1, EGFR
22tamoxifen45 51 29 1111.9BRCA2, BRCA1, PGR, ERBB2, EGFR, TP53
23leucovorin45 51 1110.8CEACAM5, EGFR, ERCC1, ERBB2, PGR
24docetaxel45 51 61 1111.7TP53, EGFR, BRCA2, BRCA1, PGR, ERCC1
25gold458.7CXCL10, BRCA2, CEACAM5, BRCA1, MUC16
26ly294002458.7ERBB2, IL8, RET, IL10, TP53, EGFR
27irinotecan45 51 1110.6ERCC1, ERBB2, EGFR, CEACAM5, TP53
28cyclophosphamide45 51 1110.6TP53, BRCA1, PGR, MUC16, ERCC1, IL10
29agar458.6ERBB2, CEACAM5, RET, PGR, EGFR, BRCA1
30mitomycin c458.6TP53, BRCA2, ERCC1, BRCA1, CEACAM5, IL10
31testosterone45 61 24 1111.5BRCA1, PGR, MUC16, ERBB2, EGFR, BRCA2
32adriamycin458.5ERBB2, CEACAM5, TP53, BRCA2, PGR, BRCA1
33sb 20358045 619.5IL8, EGFR, IFNG, TP53, IL10
34oxaliplatin45 51 1110.5BRCA1, TP53, CEACAM5, ERBB2, ERCC1, EGFR
35carboplatin45 51 1110.4ERBB2, ERCC1, BRCA1, EGFR, IFNG, MUC16
36dexamethasone45 51 29 1111.4CXCL10, IFNG, IL10, IL8, PGR, MUC16
37retinoic acid45 249.3BRCA2, PGR, CXCL10, RET, IFNG, EGFR
38genistein45 29 61 3 24 1113.2CXCL10, IL8, EGFR, ERBB2, IFNG, RET
39paclitaxel45 51 1110.2ERBB2, BRCA1, ERCC1, EGFR, MUC16, PGR
40phosphatidylinositol458.1ERBB2, CEACAM5, RET, CXCL10, BRCA1, BRCA2
41thymidine45 248.9BRCA1, IL10, ERCC1, IFNG, TP53, CEACAM5
42butyrate457.9TP53, RET, IFNG, IL8, CEACAM5
435fluorouracil457.8PGR, BRCA1, CEACAM5, EGFR, ERCC1, TP53
44cycloheximide457.7CXCL10, PGR, BRCA1, BRCA2, IL10, ERBB2
45doxorubicin45 51 119.6EGFR, ERBB2, CEACAM5, MUC16, PGR, BRCA1
46cisplatin45 51 61 1110.6BRCA2, BRCA1, MUC16, CEACAM5, ERBB2, ERCC1
47progesterone45 29 61 24 1111.4EGFR, ERBB2, TP53, BRCA2, BRCA1, PGR
48estrogen457.1EGFR, CEACAM5, TP53, BRCA2, BRCA1, ERCC1
49paraffin457.1TP53, BRCA1, PGR, MUC16, RET, CEACAM5
50vegf456.1EGFR, TP53, BRCA1, ERBB2, IL8, IL10

GO Terms for genes affiliated with Primary Peritoneal Carcinoma

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16Gene Ontology
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Cellular components related to Primary Peritoneal Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor complexGO:0432359.6EGFR, ERBB2, RET
2transcription factor TFIID complexGO:0056699.5TP53, ERCC1
3endosome membraneGO:0100089.4EGFR, ERBB2, RET
4nucleoplasmGO:0056549.0ERCC1, PGR, BRCA1, BRCA2, TP53
5basolateral plasma membraneGO:0163238.9CEACAM5, ERBB2, EGFR
6extracellular spaceGO:0056158.4EGFR, MUC16, CXCL10, IFNG, IL10, IL8

Biological processes related to Primary Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.1IFNG, IL10
2response to molecule of bacterial originGO:00223710.0IL10, IL8
3embryonic organ developmentGO:04856810.0ERCC1, TP53
4negative regulation of growth of symbiont in hostGO:04413010.0IFNG, IL10
5DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.9BRCA1, BRCA2, TP53
6positive regulation of cell cycle arrestGO:0711589.9BRCA1, TP53
7cellular response to estradiol stimulusGO:0713929.9IL10, EGFR
8response to X-rayGO:0101659.9TP53, BRCA2, ERCC1
9response to gamma radiationGO:0103329.9TP53, BRCA2, CXCL10
10nucleotide-excision repairGO:0062899.8TP53, BRCA2, ERCC1
11peptidyl-tyrosine phosphorylationGO:0181089.8EGFR, ERBB2, RET
12cell agingGO:0075699.8BRCA2, TP53
13cellular response to lipopolysaccharideGO:0712229.7IL8, IL10, IFNG
14double-strand break repairGO:0063029.6ERCC1, BRCA1, BRCA2, TP53
15positive regulation of DNA repairGO:0457399.5EGFR, BRCA1
16protein import into nucleus, translocationGO:0000609.5IFNG, TP53
17cell surface receptor signaling pathwayGO:0071669.5EGFR, ERBB2, IFNG, CXCL10
18cell cycle arrestGO:0070509.4IL8, IFNG, TP53
19cell proliferationGO:0082839.3EGFR, ERCC1, ERBB2, TP53
20positive regulation of transcription, DNA-templatedGO:0458939.3TP53, BRCA2, BRCA1, RET, IL10
21signal transductionGO:0071659.0EGFR, ERBB2, IL8, RET, CXCL10, PGR
22positive regulation of transcription from RNA polymerase II promoterGO:0459448.8EGFR, IL10, IFNG, CXCL10, BRCA1, TP53
23negative regulation of apoptotic processGO:0430668.5TP53, CEACAM5, IL10, EGFR

Molecular functions related to Primary Peritoneal Carcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1epidermal growth factor-activated receptor activityGO:0050069.9EGFR, ERBB2
2transmembrane receptor protein tyrosine kinase activityGO:0047149.7EGFR, ERBB2, RET
3receptor signaling protein tyrosine kinase activityGO:0047169.5ERBB2, EGFR
4protein tyrosine kinase activityGO:0047139.4EGFR, ERBB2, RET
5protein phosphatase bindingGO:0199039.3TP53, ERBB2, EGFR
6enzyme bindingGO:0198999.2TP53, BRCA1, PGR, EGFR
7identical protein bindingGO:0428028.5EGFR, ERBB2, CEACAM5, TP53
8protein bindingGO:0055157.1PGR, BRCA1, BRCA2, TP53, MUC16, CXCL10

Products for genes affiliated with Primary Peritoneal Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Primary Peritoneal Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet