PPNAD
MCID: PRM051
MIFTS: 51

Primary Pigmented Nodular Adrenocortical Disease (PPNAD) malady

Genetic diseases, Rare diseases, Endocrine diseases, Reproductive diseases categories
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Summaries for Primary Pigmented Nodular Adrenocortical Disease

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MalaCards based summary: Primary Pigmented Nodular Adrenocortical Disease, also known as PPNAD, is related to cushing's syndrome and carney complex. An important gene associated with Primary Pigmented Nodular Adrenocortical Disease is PDE8B (phosphodiesterase 8B), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and Nuclear Receptor transcription pathway. The compounds betamethasone and aminoglutethimide have been mentioned in the context of this disorder. Affiliated tissues include cortex, adrenal cortex and adrenal gland, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Aliases & Classifications for Primary Pigmented Nodular Adrenocortical Disease

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Primary Pigmented Nodular Adrenocortical Disease, Aliases & Descriptions:

Name: Primary Pigmented Nodular Adrenocortical Disease 42
 
Ppnad 42


Classifications:



Related Diseases for Primary Pigmented Nodular Adrenocortical Disease

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Diseases in the Pigmented Nodular Adrenocortical Disease, Primary, 2 family:

primary pigmented nodular adrenocortical disease Pigmented Nodular Adrenocortical Disease, Primary, 3
Pigmented Nodular Adrenocortical Disease, Primary, 1 Pigmented Nodular Adrenocortical Disease, Primary, 4

Diseases related to Primary Pigmented Nodular Adrenocortical Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1cushing's syndrome31.9NR3C1, POMC
2carney complex31.5GNAS, PDE8B, POMC, PDE11A, PRKAR1A
3acth-independent macronodular adrenal hyperplasia31.3GNAS
4adenoma30.2CNC2, SMARCA4, CTNNB1, SYP, IGFBP2, GNAS
5adrenal adenoma30.0POMC, PRKAR1A, CNC2, CYP19A1, GNAS
6pituitary adenoma29.6ESR2, PRKAR1A, SYP, CNC2, NR3C1, NCAM1
7gangliocytoma10.6SYP
8adrenal carcinoma10.5POMC
9pituitary carcinoma10.5POMC
10rhabdoid tumor10.5SYP
11zollinger-ellison syndrome10.5CHGA
12aromatase excess syndrome10.5CYP19A1
13central neurocytoma10.5CHGA, SYP
14antley-bixler syndrome10.5CYP19A1
15pancreatic islet cell tumors10.5CHGA, SYP
16pineocytoma10.4CHGA, SYP
17mccune albright syndrome10.4PRKAR1A, GNAS
18acrodysostosis10.4GNAS, PRKAR1A
19merkel cell carcinoma10.4CHGA, SYP
20wermer syndrome10.4PRKAR1A, CHGA
21dysembryoplastic neuroepithelial tumor10.4SYP
22acinar cell carcinoma10.4CHGA, CTNNB1
23thyroid medullary carcinoma10.4POMC, PRKAR1A, CHGA
24cerebral meningioma10.4PGR
25parathyroid adenoma10.4CHGA, GNAS, PRKAR1A
26pigmented nodular adrenocortical disease, primary, 210.4
27neuroectodermal tumor10.3SYP, NCAM1
28acth-secreting pituitary adenoma10.3NR3C1, POMC
29glucocorticoid-remediable aldosteronism10.3NR3C1, POMC
30adrenocortical carcinoma10.3PRKAR1A, IGFBP2, CTNNB1
31nelson syndrome10.3POMC, NR3C1
32hypoglycemia10.3IGFBP2, CHGA, POMC
33germ cell cancer10.3ESR2, NCAM1
34thyroid hurthle cell carcinoma10.3CHGA, GNAS, PRKAR1A
35craniopharyngioma10.3CTNNB1, POMC
36neuroendocrine carcinoma10.3CHGA, NCAM1, SYP
37aorta atresia10.3CYP19A1, IGFBP2
38paraganglioma10.3CHGA, SYP, NCAM1
39oligodendroglioma10.3IGFBP2, SYP, NCAM1
40precocious puberty10.3GNAS, POMC, CYP19A1
41leydig cell tumor10.3GNAS, CYP19A1, POMC
42neuroblastoma10.2NCAM1, SYP
43estrogen excess10.2PGR, CYP19A1
44thyroid adenoma10.2GNAS, CNC2, PRKAR1A
45short stature10.2IGFBP2, GNAS, CYP19A1
46nephrotic syndrome10.2POMC, IGFBP2, NR3C1
47non-small cell lung carcinoma10.2NCAM1, SYP, CHGA
48ganglioneuroma10.2CHGA, SYP, NCAM1, POMC
49pancreatic cancer10.2CTNNB1, CHGA, SYP, ESR2
50chronic fatigue syndrome10.2POMC, NR3C1

Graphical network of the top 20 diseases related to Primary Pigmented Nodular Adrenocortical Disease:



Diseases related to primary pigmented nodular adrenocortical disease

Symptoms for Primary Pigmented Nodular Adrenocortical Disease

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Drugs & Therapeutics for Primary Pigmented Nodular Adrenocortical Disease

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Drug clinical trials:

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Search NIH Clinical Center for Primary Pigmented Nodular Adrenocortical Disease

Genetic Tests for Primary Pigmented Nodular Adrenocortical Disease

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Anatomical Context for Primary Pigmented Nodular Adrenocortical Disease

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MalaCards organs/tissues related to Primary Pigmented Nodular Adrenocortical Disease:

32
Cortex, Adrenal cortex, Adrenal gland, Pituitary

Animal Models for Primary Pigmented Nodular Adrenocortical Disease or affiliated genes

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MGI Mouse Phenotypes related to Primary Pigmented Nodular Adrenocortical Disease:

36 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.4CTNNB1, PRKAR1A, POMC, CYP19A1
2MP:00053718.5SMARCA4, GNAS, PGR, ESR2, ESR1, CTNNB1
3MP:00053758.5CYP19A1, GNAS, POMC, ESR2, ESR1, PRKACA
4MP:00020068.5SMARCA4, POMC, PGR, ESR2, ESR1, PRKACA
5MP:00053888.5SMARCA4, GNAS, ESR2, ESR1, PRKAR1A, NR3C1
6MP:00053818.4SMARCA4, ESR2, ESR1, PRKAR1A, NR3C1, CTNNB1
7MP:00030128.2GNAS, POMC, PGR, ESR2, ESR1, SYP
8MP:00053698.0CYP19A1, SMARCA4, GNAS, PGR, ESR2, ESR1
9MP:00107717.9CYP19A1, SMARCA4, GNAS, POMC, PGR, ESR2
10MP:00053897.8CYP19A1, PGR, ESR2, ESR1, CHGA, PRKACA
11MP:00053707.7IGFBP2, CYP19A1, SMARCA4, GNAS, POMC, ESR2
12MP:00053807.7SMARCA4, PGR, ESR1, PRKACA, PRKACB, PRKAR1A
13MP:00028737.7IGFBP2, CYP19A1, GNAS, PGR, ESR2, PRKAR1A
14MP:00053797.6CYP19A1, GNAS, POMC, PGR, ESR2, ESR1
15MP:00053677.5CTNNB1, IGFBP2, SMARCA4, GNAS, POMC, ESR2
16MP:00053787.4CYP19A1, GNAS, POMC, ESR2, ESR1, CHGA
17MP:00053847.3POMC, GNAS, SMARCA4, CYP19A1, PGR, ESR2
18MP:00053907.2CYP19A1, GNAS, PGR, ESR2, ESR1, PRKACA
19MP:00053767.2PGR, POMC, GNAS, SMARCA4, CYP19A1, ESR2
20MP:00053977.1IGFBP2, CYP19A1, SMARCA4, GNAS, POMC, PGR
21MP:00053877.1GNAS, SMARCA4, CYP19A1, IGFBP2, POMC, PGR
22MP:00053856.7POMC, GNAS, SMARCA4, CYP19A1, IGFBP2, PGR
23MP:00053866.7PGR, POMC, GNAS, CYP19A1, ESR2, ESR1
24MP:00036316.5ESR2, POMC, GNAS, SMARCA4, CYP19A1, ESR1
25MP:00107686.5ESR2, PGR, POMC, GNAS, SMARCA4, ESR1

Publications for Primary Pigmented Nodular Adrenocortical Disease

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Articles related to Primary Pigmented Nodular Adrenocortical Disease:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD). (24865460)
2014
2
Does somatostatin have a role in the regulation of cortisol secretion in primary pigmented nodular adrenocortical disease (ppnad)? a clinical and in vitro investigation. (24512486)
2014
3
A rare case of familial Cushing's syndrome with a common presentation of weight gain due to a mutation of the PRKAR1A gene causing isolated primary pigmented nodular adrenocortical disease. (24859511)
2014
4
A novel PRKAR1A gene mutation associated with primary pigmented nodular adrenocortical disease. (24978147)
2014
5
Primary pigmented nodular adrenocortical disease: the original 4 cases revisited after 30 years for follow-up, new investigations, and molecular genetic findings. (24805858)
2014
6
Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome. (23065993)
2013
7
An unusual presentation of Carney complex with diffuse primary pigmented nodular adrenocortical disease on one adrenal gland and a nonpigmented adrenocortical adenoma and focal primary pigmented nodular adrenocortical disease on the other. (22785148)
2012
8
Causes and consequences of abandoning one-stage bilateral adrenalectomy recommended in primary pigmented nodular adrenocortical disease--case presentation. (21932601)
2011
9
Children with Cushing's syndrome: Primary Pigmented Nodular Adrenocortical Disease should always be suspected. (20924687)
2011
10
A case of subclinical Cushing syndrome due to primary pigmented nodular adrenocortical disease associated with adrenocortical adenoma. (21442380)
2011
11
Primary pigmented nodular adrenocortical disease: a case report in a 7-year-old girl. (21648292)
2011
12
Primary pigmented nodular adrenocortical disease. (21717412)
2011
13
Laparoscopic unilateral adrenalectomy in children for isolated primary pigmented nodular adrenocortical disease (PPNAD): case report and literature review. (20099223)
2010
14
Familial isolated primary pigmented nodular adrenocortical disease associated with a novel low penetrance PRKAR1A gene splice site mutation. (20190548)
2010
15
CT findings of primary pigmented nodular adrenocortical disease: rare cause of ACTH-independent Cushing syndrome. (20489078)
2010
16
Primary pigmented nodular adrenocortical disease presenting with a unilateral adrenocortical nodule treated with bilateral laparoscopic adrenalectomy: a case report. (20670433)
2010
17
Association of the M1V PRKAR1A mutation with primary pigmented nodular adrenocortical disease in two large families. (19915019)
2010
18
MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling. (19351815)
2009
19
The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits. (19383776)
2009
20
Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease, and other corticotropin-independent lesions. (18491255)
2008
21
Expression of progesterone and estradiol receptors in normal adrenal cortex, adrenocortical tumors, and primary pigmented nodular adrenocortical disease. (18508999)
2008
22
Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). (18419788)
2008
23
Primary pigmented nodular adrenocortical disease reveals insulin-like growth factor binding protein-2 regulation by protein kinase A. (17280861)
2007
24
Primary pigmented nodular adrenocortical disease and Cushing's syndrome. (18209861)
2007
25
Primary pigmented nodular adrenocortical disease (PPNAD) and pituitary adenoma in a boy with sporadic Carney complex due to a novel, de novo paternal PRKAR1A mutation (R96X). (17396442)
2007
26
Primary pigmented nodular adrenocortical disease with synaptophysin immunoreactivity in two thai children. (17624220)
2007
27
A PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease in 12 kindreds. (16464939)
2006
28
Primary pigmented nodular adrenocortical disease associated with Carney complex: case report and literature review. (17322955)
2006
29
Primary pigmented nodular adrenocortical disease: report of 5 cases. (16701022)
2006
30
Bilateral adrenal Cushing's syndrome: macronodular adrenal hyperplasia and primary pigmented nodular adrenocortical disease. (15850852)
2005
31
Cyclical Cushing syndrome presenting in infancy: an early form of primary pigmented nodular adrenocortical disease, or a new entity? (15240590)
2004
32
Clinical and molecular genetics of primary pigmented nodular adrenocortical disease. (15761532)
2004
33
Primary pigmented nodular adrenocortical disease: paradoxical responses of cortisol secretion to dexamethasone occur in vitro and are associated with increased expression of the glucocorticoid receptor. (12915689)
2003
34
Carney complex, a familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease: a case report. (12670039)
2002
35
Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. (12213893)
2002
36
Paradoxical response to dexamethasone in the diagnosis of primary pigmented nodular adrenocortical disease. (10523219)
1999
37
Synaptophysin immunoreactivity in primary pigmented nodular adrenocortical disease: neuroendocrine properties of tumors associated with Carney complex. (10084605)
1999
38
Primary pigmented nodular adrenocortical disease: reevaluation of a patient with carney complex 27 years after unilateral adrenalectomy. (9100606)
1997
39
Relapse of Cushing's syndrome following the treatment of primary pigmented nodular adrenocortical disease by unilateral adrenalectomy. (8811225)
1996
40
Cushing's syndrome due to primary pigmented nodular adrenocortical disease--a case report reviews of the literature. (7626560)
1995
41
Use of a two-site immunoradiometric assay to resolve a factitious elevation of ACTH in primary pigmented nodular adrenocortical disease. (8186827)
1994
42
Bilateral primary pigmented nodular adrenocortical disease--a case of report describing a rare cause of Cushing's syndrome. (7786440)
1994
43
Carney's complex with primary pigmented nodular adrenocortical disease and spotty pigmentations. (8495049)
1993
44
Carney's complex of primary pigmented nodular adrenocortical disease and pigmentous and myxomatous lesions. (2711295)
1989
45
Primary pigmented nodular adrenocortical disease. A light and electron microscopic study of eight cases. (2679153)
1989
46
Familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease. Reinvestigation 50 years later. (2586567)
1989
47
Cushing syndrome due to primary pigmented nodular adrenocortical disease: findings at CT and MR imaging. (2748822)
1989
48
Cushing's syndrome resulting from primary pigmented nodular adrenocortical disease. (3752018)
1986
49
Primary pigmented nodular adrenocortical disease: diagnosis and management. (3787476)
1986
50
Bilateral primary pigmented nodular adrenocortical disease. Rare cause of the Cushing syndrome. (6329005)
1984

Variations for Primary Pigmented Nodular Adrenocortical Disease

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Expression for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

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Expression patterns in normal tissues for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

Search GEO for disease gene expression data for Primary Pigmented Nodular Adrenocortical Disease.

Pathways for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

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Pathways related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 108)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CYP19A1, ESR2, ESR1
2
Show member pathways
Nuclear Receptors37
9.0PGR, ESR2, ESR1, NR3C1
38.9PRKACG, PRKACA, PRKACB
48.9PRKACB, PRKACG, PRKACA
58.9PRKACG, PRKACB, PRKACA
68.7PRKAR1A, PRKACG, PRKACB, PRKACA
78.7PRKAR1A, PRKACG, PRKACB, PRKACA
88.7PRKAR1A, PRKACB, PRKACA, PRKACG
98.7PRKACB, PRKACA, PRKACG, PRKAR1A
108.7PRKACA, PRKACG, PRKAR1A, PRKACB
118.7PRKACA, PRKACB, PRKACG, PRKAR1A
128.7GNAS, PRKACG, PRKACB, PRKACA
138.7PRKACA, PRKACB, PRKACG, GNAS
14
Show member pathways
8.7PRKACB, GNAS, PRKACA, PRKACG
158.7PRKACA, PRKACG, PRKACB, GNAS
168.6PRKACA, PRKACB, PRKACG, NCAM1
178.5PRKACB, PRKACG, PRKAR1A, PRKACA, POMC
18
Show member pathways
8.5PRKACA, PRKACB, PRKACG, PRKAR1A, SMARCA4
19
Show member pathways
Development EDNRB signaling60
Development ACM2 and ACM4 activation of ERK60
Cell adhesion Integrin inside out signaling60
Development G Proteins mediated regulation MARK ERK signaling60
Signal transduction IP3 signaling60
Development Angiotensin signaling via PYK260
Development EPO induced MAPK pathway60
8.5PRKAR1A, PRKACG, PRKACB, GNAS, PRKACA
20
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
8.5PRKACB, PRKACA, GNAS, PRKACG, PRKAR1A
21
Show member pathways
8.5PRKACA, PRKAR1A, PRKACG, PRKACB, GNAS
22
Show member pathways
8.5GNAS, PRKACA, PRKACB, PRKACG, PRKAR1A
23
Show member pathways
8.5PRKACB, PRKACG, GNAS, PRKACA, PRKAR1A
24
Show member pathways
8.5PRKACB, PRKACA, GNAS, PRKAR1A, PRKACG
258.5GNAS, PRKACA, PRKACG, PRKAR1A, PRKACB
26
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
8.5PRKACA, GNAS, PRKACB, PRKACG, PRKAR1A
278.5PRKACG, PRKACB, PRKACA, GNAS, PRKAR1A
288.5PRKACG, GNAS, PRKACA, PRKACB, PRKAR1A
29
Show member pathways
8.4PRKACG, PRKACA, POMC, GNAS, PRKACB
30
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
8.4PRKAR1A, PRKACB, PRKACG, PRKACA, CTNNB1
318.4CTNNB1, PRKAR1A, PRKACG, PRKACA, PRKACB
32
Show member pathways
Calcium Regulation in the Cardiac Cell37
8.4IGFBP2, PRKACA, PRKACB, PRKAR1A, GNAS
33
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
8.4GNAS, PRKACB, PRKACG, CTNNB1, PRKACA
348.3PRKACA, CYP19A1, GNAS, PRKACB, PRKACG
358.3NR3C1, CTNNB1, PRKACA, ESR2, PRKACB, PRKAR1A
36
Show member pathways
Signal transduction cAMP signaling60
8.3PRKACG, PRKACB, PRKACA, GNAS, PDE8B, PRKAR1A
37
Show member pathways
8.2PRKACB, PRKAR1A, PRKACA, GNAS, PRKACG, POMC
388.2PRKACG, PRKACB, CYP19A1, PRKACA, NR3C1
398.2PRKACG, GNAS, PRKACB, ESR1, PRKACA
40
Show member pathways
8.2PRKACB, PRKACG, PDE11A, PDE8B, PRKACA, GNAS
418.2ESR1, PRKACG, CTNNB1, PRKACB, PRKACA
428.2PRKACA, ESR1, PRKACB, PRKACG, CTNNB1
43
Show member pathways
Development A2B receptor action via G protein alpha s60
8.2CTNNB1, PRKAR1A, PRKACG, PRKACB, PRKACA, GNAS
44
Show member pathways
8.2PRKACA, PRKACB, PRKACG, PRKAR1A, CTNNB1, GNAS
45
Show member pathways
8.1GNAS, PRKACG, CTNNB1, PRKACB, POMC, PRKACA
468.1PRKACB, PRKACA, POMC, NR3C1, SMARCA4, PRKACG
47
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
7.7ESR2, GNAS, ESR1, PRKACA, PRKACB, PRKACG
48
Show member pathways
7.7ESR2, PRKAR1A, PRKACG, PRKACB, PRKACA, ESR1
49
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
7.6CTNNB1, GNAS, PRKACB, PRKACA, ESR1, ESR2
50
Show member pathways
6.6POMC, ESR1, GNAS, PDE11A, PDE8B, PRKACB

Compounds for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

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Compounds related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 204)
idCompoundScoreTop Affiliating Genes
1betamethasone44 1110.6SYP, CYP19A1, POMC, NR3C1
2aminoglutethimide44 1110.4NR3C1, CYP19A1, ESR1, POMC
3idoxifene449.4ESR1, PGR, CYP19A1
4estradiol benzoate449.4CYP19A1, PGR, ESR2, ESR1
5leuprolide acetate449.3PGR, CYP19A1, ESR1, ESR2
6trilostane44 1110.3ESR2, PGR, ESR1, NR3C1
7anastrozole44 50 1111.3PGR, ESR1, CYP19A1, ESR2
8exemestane44 50 61 1112.3ESR2, CYP19A1, ESR1, PGR
9letrozole44 50 61 1112.2PGR, SYP, ESR1, CYP19A1, ESR2
10bisphenol a449.2CYP19A1, PGR, ESR2, ESR1
11megestrol acetate449.1CYP19A1, POMC, ESR1, NR3C1, PGR
12pka inhibitor fragment (6-22) amide619.1PRKAR1A, PRKACA, PRKACG, PRKACB
13camps-sp, triethylammonium salt619.1PRKACA, PRKACB, PRKACG, PRKAR1A
14h 89 dihydrochloride619.1PRKACG, PRKACB, PRKACA, PRKAR1A
15toremifene44 1110.1ESR1, ESR2, CYP19A1, PGR
16pki 14-22 amide, myristoylated619.1PRKACA, PRKACB, PRKACG, PRKAR1A
17nandrolone44 2410.1CYP19A1, PGR, ESR2, ESR1, NR3C1
18clomiphene citrate449.0CYP19A1, PGR, ESR2, ESR1
19fulvestrant44 50 28 1112.0CYP19A1, ESR1, ESR2, PGR
20dhea448.9POMC, IGFBP2, ESR2, NR3C1, CYP19A1
21gaba448.8CHGA, SYP, NCAM1, PGR, ESR2, POMC
224-hydroxytamoxifen448.8CTNNB1, NR3C1, ESR1, ESR2, CYP19A1, PGR
23forskolin44 50 1110.7SYP, POMC, CHGA, PRKACA, PRKAR1A, IGFBP2
24bicalutamide44 61 1110.7CYP19A1, CTNNB1, CHGA, ESR1, IGFBP2, ESR2
25acth448.7NR3C1, SYP, CHGA, POMC, GNAS, IGFBP2
26vitamin d448.7CTNNB1, PRKAR1A, CHGA, CYP19A1, NR3C1, ESR2
27dopamine44 28 24 1111.6NR3C1, NCAM1, CHGA, ESR2, POMC, GNAS
28mifepristone44 28 61 1111.6ESR1, NR3C1, ESR2, CYP19A1, CTNNB1, PGR
29steroidal448.5IGFBP2, CYP19A1, NR3C1, ESR1, ESR2, PGR
30progestins448.5PGR, NR3C1, ESR1, IGFBP2, CYP19A1, ESR2
31kt 572044 61 2810.4PRKACA, PRKACB, PRKACG, PRKAR1A
32paraffin448.4POMC, PGR, ESR2, ESR1, CHGA, SYP
33doxorubicin44 50 1110.3NR3C1, NCAM1, CTNNB1, ESR1, ESR2, PGR
34glutamine448.3SYP, NR3C1, NCAM1, POMC, CTNNB1, GNAS
35progestin448.3NR3C1, ESR1, ESR2, PGR, POMC, CYP19A1
36cysteine448.3SMARCA4, GNAS, ESR2, CHGA, NCAM1, SYP
37tamoxifen44 50 28 1111.2CTNNB1, CHGA, ESR1, ESR2, PGR, CYP19A1
38dihydrotestosterone44 28 24 1111.2IGFBP2, CYP19A1, PGR, ESR2, ESR1, NR3C1
39estradiol44 24 1110.0IGFBP2, CYP19A1, PGR, NR3C1, SYP, ESR2
40arginine447.7CYP19A1, IGFBP2, SMARCA4, POMC, GNAS, ESR2
41cycloheximide447.7CYP19A1, IGFBP2, CTNNB1, NR3C1, CHGA, ESR1
42gnrh447.5CYP19A1, GNAS, POMC, PGR, ESR2, ESR1
43vegf447.5SYP, PGR, CTNNB1, ESR2, ESR1, NR3C1
44retinoic acid44 248.3CTNNB1, NCAM1, NR3C1, SYP, CHGA, PGR
45dexamethasone44 50 28 1110.2CTNNB1, NCAM1, NR3C1, SYP, PRKACA, CHGA
46cyclic amp44 248.2PDE8B, PDE11A, CNC2, SYP, GNAS, SMARCA4
47testosterone44 61 24 119.9SYP, NR3C1, NCAM1, CTNNB1, CHGA, ESR1
48estrogen446.9PGR, ESR2, ESR1, POMC, CHGA, NR3C1
49steroid446.8SYP, PRKAR1A, CHGA, ESR1, ESR2, PGR
50progesterone44 28 61 24 1110.7GNAS, POMC, PGR, ESR2, ESR1, CHGA

GO Terms for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

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Cellular components related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase complexGO:0315889.8PRKAR1A, PRKACA
2cAMP-dependent protein kinase complexGO:0059529.4PRKAR1A, PRKACB, PRKACA
3membraneGO:0160208.6CYP19A1, GNAS, ESR1, PRKACA, NR3C1, CTNNB1
4extracellular regionGO:0055768.5GNAS, POMC, ESR2, CHGA, NCAM1, IGFBP2
5nucleoplasmGO:0056547.8PGR, ESR2, ESR1, PRKACB, NR3C1, CTNNB1
6cytosolGO:0058297.3GNAS, PRKACA, PRKACB, PRKACG, PRKAR1A, PDE11A

Biological processes related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1glial cell fate determinationGO:00740310.3CTNNB1, SMARCA4
2hair follicle placode formationGO:06078910.2CTNNB1, GNAS
3negative regulation of androgen receptor signaling pathwayGO:06076610.1ESR2, SMARCA4
4cAMP catabolic processGO:00619810.1PDE8B, PDE11A
5uterus developmentGO:06006510.0ESR1, ESR2
6embryonic hindlimb morphogenesisGO:03511610.0SMARCA4, GNAS, CTNNB1
7vagina developmentGO:06006810.0ESR1, ESR2
8hindbrain developmentGO:0309029.8SMARCA4, CTNNB1
9intracellular estrogen receptor signaling pathwayGO:0305209.8ESR1, ESR2
10positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.7ESR1, ESR2, SMARCA4
11androgen metabolic processGO:0082099.7ESR1, CYP19A1
12response to estradiolGO:0323559.4CTNNB1, ESR1, IGFBP2
13transcription initiation from RNA polymerase II promoterGO:0063679.3NR3C1, ESR1, ESR2, PGR
14triglyceride catabolic processGO:0194339.3PRKACG, PRKACB, PRKACA
15gluconeogenesisGO:0060949.3PRKACA, PRKACB, PRKACG
16activation of protein kinase A activityGO:0341999.1PRKAR1A, PRKACG, PRKACB, PRKACA
17activation of phospholipase C activityGO:0072029.1PRKACA, PRKACB, PRKACG, PRKAR1A
18fibroblast growth factor receptor signaling pathwayGO:0085439.1PRKAR1A, PRKACG, PRKACB, PRKACA
19epidermal growth factor receptor signaling pathwayGO:0071739.0PRKACA, PRKACB, PRKACG, PRKAR1A
20glucose metabolic processGO:0060069.0PRKACA, PRKACB, PRKACG
21neurotrophin TRK receptor signaling pathwayGO:0480119.0PRKACA, PRKACB, PRKACG, PRKAR1A
22intracellular signal transductionGO:0355568.9PRKACA, PRKACB, PRKACG, PRKAR1A
23cellular response to glucagon stimulusGO:0713778.9GNAS, PRKACA, PRKACB, PRKACG, PRKAR1A
24water transportGO:0068338.8GNAS, PRKACA, PRKACB, PRKACG, PRKAR1A
25regulation of insulin secretionGO:0507968.8GNAS, PRKACA, PRKACB, PRKACG, PRKAR1A
26energy reserve metabolic processGO:0061128.8PRKAR1A, PRKACG, PRKACB, PRKACA, GNAS
27transmembrane transportGO:0550858.8GNAS, PRKACA, PRKACB, PRKACG, PRKAR1A
28innate immune responseGO:0450878.7PRKACA, PRKACB, PRKACG, PRKAR1A, CTNNB1
29blood coagulationGO:0075968.5GNAS, PRKACA, PRKACB, PRKACG, PRKAR1A, PDE11A
30small molecule metabolic processGO:0442817.8CYP19A1, GNAS, PRKACA, PRKACB, PRKACG, PRKAR1A
31signal transductionGO:0071656.5NR3C1, IGFBP2, POMC, PGR, ESR2, ESR1

Molecular functions related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
13,5-cyclic-nucleotide phosphodiesterase activityGO:00411410.1PDE11A, PDE8B
2cAMP bindingGO:03055210.0PDE11A, PRKAR1A
3estrogen response element bindingGO:0340569.9ESR1, ESR2
4estrogen receptor activityGO:0302849.9ESR1, ESR2
5ionotropic glutamate receptor bindingGO:0352559.8GNAS, CTNNB1
6steroid hormone receptor activityGO:0037079.6PGR, ESR2, ESR1
7core promoter sequence-specific DNA bindingGO:0010469.5ESR1, ESR2
8steroid bindingGO:0054969.2NR3C1, ESR1, ESR2, PGR
9enzyme bindingGO:0198999.2PGR, ESR2, ESR1, CTNNB1
10cAMP-dependent protein kinase activityGO:0046919.1PRKACG, PRKACB, PRKACA
11protein bindingGO:0055156.3IGFBP2, SMARCA4, GNAS, PGR, ESR2, ESR1

Products for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

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Sources for Primary Pigmented Nodular Adrenocortical Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet