PPNAD
MCID: PRM051
MIFTS: 42

Primary Pigmented Nodular Adrenocortical Disease (PPNAD) malady

Endocrine category

Summaries for Primary Pigmented Nodular Adrenocortical Disease

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33MalaCards
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MalaCards: Primary Pigmented Nodular Adrenocortical Disease, also known as PPNAD, is related to cushing's syndrome and carney complex. An important gene associated with Primary Pigmented Nodular Adrenocortical Disease is PDE8B (phosphodiesterase 8B), and among its related pathways are Estrogen biosynthesis and Nuclear Receptor transcription pathway. The compounds cycloheximide and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include cortex, adrenal gland and adrenal cortex, and related mouse phenotypes are endocrine/exocrine gland and limbs/digits/tail.

Aliases & Classifications for Primary Pigmented Nodular Adrenocortical Disease

Sources:
43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

primary pigmented nodular adrenocortical disease 43
ppnad 43


Related Diseases for Primary Pigmented Nodular Adrenocortical Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases in the pigmented nodular adrenocortical disease, primary, 2 family:

primary pigmented nodular adrenocortical disease pigmented nodular adrenocortical disease, primary, 3
pigmented nodular adrenocortical disease, primary, 1

Diseases related to Primary Pigmented Nodular Adrenocortical Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1cushing's syndrome31.4NR3C1, POMC
2carney complex31.3GNAS, PDE8B, PDE11A, PRKAR1A, POMC
3adenoma31.0ESR2, CHGA, SMARCA4, CNC, GNAS, CTNNB1
4adrenal adenoma30.7GNAS, PRKAR1A, CYP19A1, POMC, CNC
5n syndrome11.0
6adrenal cortex disease10.5
7adrenal gland disease10.5
8cushing syndrome, familial10.5
9acth-independent macronodular adrenal hyperplasia10.3
10pigmented nodular adrenocortical disease, primary, 210.3
11pigmented nodular adrenocortical disease, primary, 110.0
12rhabdoid tumor10.0SYP
13thyroiditis10.0POMC
14meningitis10.0IGFBP2
15hepatitis10.0IGFBP2
16tuberous sclerosis10.0SYP
17atherosclerosis10.0ESR2
18leiomyosarcoma10.0PGR
19gangliocytoma10.0SYP
20sertoli-leydig cell tumor10.0PGR
21desmoid tumor10.0CTNNB1
22hyperthyroidism10.0GNAS
23phaeochromocytoma10.0CHGA
24hyperparathyroidism10.0CHGA, PRKAR1A
25bipolar disorder10.0NR3C1
26wermer syndrome10.0CHGA, PRKAR1A
27azoospermia10.0ESR2
28hypercalcemia10.0CHGA, PRKAR1A
29rhabdomyosarcoma10.0NCAM1
30merkel cell carcinoma10.0CHGA, SYP
31cervical cancer10.0NR3C1
32addison's disease10.0POMC
33alzheimer's disease10.0SYP, ESR2
34gastrinoma10.0CHGA, SYP
35mccune albright syndrome10.0PRKAR1A, GNAS
36growth hormone deficiency10.0IGFBP2, POMC
37anorexia nervosa10.0POMC, IGFBP2
38down syndrome10.0SMARCA4
39cholera10.0POMC, GNAS
40hypothyroidism10.0POMC, GNAS
41arthritis10.0POMC, ESR2
42cerebral meningioma10.0PGR
43central neurocytoma10.0CHGA, SYP
44hyperprolactinemia10.0GNAS, POMC
45hypertension10.0POMC, NR3C1
46acrodysostosis10.0PRKAR1A, GNAS
47pseudohermaphroditism10.0CYP19A1
48neuroblastoma10.0SYP, NCAM1
49thyroid adenoma10.0PRKAR1A, CNC, GNAS
50aromatase excess syndrome10.0CYP19A1

Graphical network of the top 20 diseases related to Primary Pigmented Nodular Adrenocortical Disease:



Diseases related to primary pigmented nodular adrenocortical disease

Clinical Features for Primary Pigmented Nodular Adrenocortical Disease

Drugs & Therapeutics for Primary Pigmented Nodular Adrenocortical Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Primary Pigmented Nodular Adrenocortical Disease

Drug clinical trials:

Search ClinicalTrials for Primary Pigmented Nodular Adrenocortical Disease

Search NIH Clinical Center for Primary Pigmented Nodular Adrenocortical Disease

Search CenterWatch for Primary Pigmented Nodular Adrenocortical Disease

Genetic Tests for Primary Pigmented Nodular Adrenocortical Disease

Anatomical Context for Primary Pigmented Nodular Adrenocortical Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Primary Pigmented Nodular Adrenocortical Disease:

33
Cortex, Adrenal gland, Adrenal cortex, Pituitary

Animal Models for Primary Pigmented Nodular Adrenocortical Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Primary Pigmented Nodular Adrenocortical Disease:

37 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.2NR3C1, ESR2
2MP:000537110.0SMARCA4
3MP:00053679.9CHGA, ESR2, GNAS, POMC
4MP:00053899.7NR3C1, PRKAR1A, CTNNB1
5MP:00107719.2SMARCA4, GNAS, CTNNB1, NR3C1, POMC
6MP:00053698.9CYP19A1, SMARCA4, PRKAR1A, ESR2, ESR1
7MP:00053758.6PRKAR1A, PRKACA, NR3C1, CYP19A1, ESR1, ESR2
8MP:00030128.4ESR2, ESR1, PGR, POMC, NR3C1, GNAS
9MP:00020068.4PRKAR1A, PGR, SMARCA4, ESR2, ESR1, POMC
10MP:00053768.3NR3C1, SMARCA4, ESR1, PGR, POMC, PRKACA
11MP:00053888.0ESR1, GNAS, CTNNB1, PRKAR1A, ESR2, SMARCA4
12MP:00053907.7PRKAR1A, PRKACB, PRKACA, NR3C1, CYP19A1, PGR
13MP:00028737.6SYP, CTNNB1, ESR2, PGR, CYP19A1, IGFBP2
14MP:00053707.4GNAS, SMARCA4, ESR2, ESR1, CYP19A1, CTNNB1
15MP:00053787.3PRKAR1A, CHGA, POMC, NR3C1, CYP19A1, ESR1
16MP:00053867.2CTNNB1, PRKACB, NCAM1, NR3C1, POMC, CYP19A1
17MP:00053847.1ESR1, GNAS, PRKAR1A, SMARCA4, ESR2, PGR
18MP:00053976.9ESR2, ESR1, PGR, CYP19A1, POMC, IGFBP2
19MP:00053876.8PRKAR1A, CTNNB1, NR3C1, IGFBP2, SMARCA4, ESR2
20MP:00107686.7PRKAR1A, CTNNB1, ESR1, PGR, POMC, CHGA
21MP:00036316.7NR3C1, POMC, SYP, NCAM1, PRKACA, PRKACB
22MP:00053856.5SMARCA4, GNAS, CTNNB1, PRKAR1A, PRKACA, NR3C1

Publications for Primary Pigmented Nodular Adrenocortical Disease

Sources:
51PubMed
See all sources

Articles related to Primary Pigmented Nodular Adrenocortical Disease:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome. (23065993)
2013
2
An unusual presentation of Carney complex with diffuse primary pigmented nodular adrenocortical disease on one adrenal gland and a nonpigmented adrenocortical adenoma and focal primary pigmented nodular adrenocortical disease on the other. (22785148)
2012
3
Causes and consequences of abandoning one-stage bilateral adrenalectomy recommended in primary pigmented nodular adrenocortical disease--case presentation. (21932601)
2011
4
Children with Cushing's syndrome: Primary Pigmented Nodular Adrenocortical Disease should always be suspected. (20924687)
2011
5
A case of subclinical Cushing syndrome due to primary pigmented nodular adrenocortical disease associated with adrenocortical adenoma. (21442380)
2011
6
Primary pigmented nodular adrenocortical disease: a case report in a 7-year-old girl. (21648292)
2011
7
Primary pigmented nodular adrenocortical disease. (21717412)
2011
8
Primary pigmented nodular adrenocortical disease. (22121318)
2011
9
Laparoscopic unilateral adrenalectomy in children for isolated primary pigmented nodular adrenocortical disease (PPNAD): case report and literature review. (20099223)
2010
10
Familial isolated primary pigmented nodular adrenocortical disease associated with a novel low penetrance PRKAR1A gene splice site mutation. (20190548)
2010
11
CT findings of primary pigmented nodular adrenocortical disease: rare cause of ACTH-independent Cushing syndrome. (20489078)
2010
12
Primary pigmented nodular adrenocortical disease presenting with a unilateral adrenocortical nodule treated with bilateral laparoscopic adrenalectomy: a case report. (20670433)
2010
13
Association of the M1V PRKAR1A mutation with primary pigmented nodular adrenocortical disease in two large families. (19915019)
2010
14
A novel PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease and the Carney complex. (19833579)
2010
15
MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling. (19351815)
2009
16
The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits. (19383776)
2009
17
Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease, and other corticotropin-independent lesions. (18491255)
2008
18
Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). (18419788)
2008
19
Primary pigmented nodular adrenocortical disease reveals insulin-like growth factor binding protein-2 regulation by protein kinase A. (17280861)
2007
20
Primary pigmented nodular adrenocortical disease and Cushing's syndrome. (18209861)
2007
21
Primary pigmented nodular adrenocortical disease (PPNAD) and pituitary adenoma in a boy with sporadic Carney complex due to a novel, de novo paternal PRKAR1A mutation (R96X). (17396442)
2007
22
Primary pigmented nodular adrenocortical disease with synaptophysin immunoreactivity in two thai children. (17624220)
2007
23
A PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease in 12 kindreds. (16464939)
2006
24
Primary pigmented nodular adrenocortical disease associated with Carney complex: case report and literature review. (17322955)
2006
25
Primary pigmented nodular adrenocortical disease: report of 5 cases. (16701022)
2006
26
PRKAR1A mutations in primary pigmented nodular adrenocortical disease. (17036196)
2006
27
Bilateral adrenal Cushing's syndrome: macronodular adrenal hyperplasia and primary pigmented nodular adrenocortical disease. (15850852)
2005
28
Cyclical Cushing syndrome presenting in infancy: an early form of primary pigmented nodular adrenocortical disease, or a new entity? (15240590)
2004
29
Clinical and molecular genetics of primary pigmented nodular adrenocortical disease. (15761532)
2004
30
Primary pigmented nodular adrenocortical disease: paradoxical responses of cortisol secretion to dexamethasone occur in vitro and are associated with increased expression of the glucocorticoid receptor. (12915689)
2003
31
Carney complex, a familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease: a case report. (12670039)
2002
32
Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. (12213893)
2002
33
Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD. (12424709)
2002
34
Paradoxical response to dexamethasone in the diagnosis of primary pigmented nodular adrenocortical disease. (10523219)
1999
35
Synaptophysin immunoreactivity in primary pigmented nodular adrenocortical disease: neuroendocrine properties of tumors associated with Carney complex. (10084605)
1999
36
Primary pigmented nodular adrenocortical disease: reevaluation of a patient with carney complex 27 years after unilateral adrenalectomy. (9100606)
1997
37
Relapse of Cushing's syndrome following the treatment of primary pigmented nodular adrenocortical disease by unilateral adrenalectomy. (8811225)
1996
38
Cushing's syndrome due to primary pigmented nodular adrenocortical disease--a case report reviews of the literature. (7626560)
1995
39
Use of a two-site immunoradiometric assay to resolve a factitious elevation of ACTH in primary pigmented nodular adrenocortical disease. (8186827)
1994
40
Bilateral primary pigmented nodular adrenocortical disease--a case of report describing a rare cause of Cushing's syndrome. (7786440)
1994
41
Carney's complex with primary pigmented nodular adrenocortical disease and spotty pigmentations. (8495049)
1993
42
Cushing's syndrome due to primary pigmented nodular adrenocortical disease with cardiac myxomas and mucocutaneous lentigines. (1600314)
1992
43
Primary pigmented nodular adrenocortical disease (PPNAD): immunohistochemical and in situ hybridization analysis of steroidogenic enzymes in eight cases. (1542635)
1992
44
Carney's complex of primary pigmented nodular adrenocortical disease and pigmentous and myxomatous lesions. (2711295)
1989
45
Primary pigmented nodular adrenocortical disease. A light and electron microscopic study of eight cases. (2679153)
1989
46
Familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease. Reinvestigation 50 years later. (2586567)
1989
47
Cushing syndrome due to primary pigmented nodular adrenocortical disease: findings at CT and MR imaging. (2748822)
1989
48
Cushing's syndrome resulting from primary pigmented nodular adrenocortical disease. (3752018)
1986
49
Primary pigmented nodular adrenocortical disease: diagnosis and management. (3787476)
1986
50
Bilateral primary pigmented nodular adrenocortical disease. Rare cause of the Cushing syndrome. (6329005)
1984

Genetic Variations for Primary Pigmented Nodular Adrenocortical Disease

Expression for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

Search GEO for disease gene expression data for Primary Pigmented Nodular Adrenocortical Disease.

Pathways for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

Sources:
54Reactome, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN, 30KEGG, 60Tocris Bioscience
See all sources

Pathways related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 93)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4CYP19A1, ESR1, ESR2
2
Hide members
9.2PGR, NR3C1, ESR2, ESR1
39.1PRKACB, PRKACA, PRKACG
49.1PRKACB, PRKACG, PRKACA
59.1PRKACG, PRKACB, PRKACA
6
G-protein signaling Rap1B regulation pathway
Hide members
9.1PRKACG, PRKACA, PRKACB
78.9PRKAR1A, PRKACB, PRKACA, PRKACG
8
Development Leptin signaling via PI3K-dependent pathway
Hide members
8.9PRKACA, PRKAR1A, PRKACB, PRKACG
98.9PRKACA, PRKACB, PRKACG, PRKAR1A
108.9PRKACG, PRKACB, PRKACA, PRKAR1A
118.9PRKACG, PRKACB, PRKACA, PRKAR1A
128.9PRKACG, PRKACB, PRKAR1A, PRKACA
138.9GNAS, PRKACG, PRKACA, PRKACB
148.9PRKACB, PRKACA, GNAS, PRKACG
15
Hide members
8.9GNAS, PRKACB, PRKACG, PRKACA
168.9PRKACG, GNAS, PRKACB, PRKACA
178.8NCAM1, PRKACA, PRKACB, PRKACG
188.7PRKACA, POMC, PRKACG, PRKAR1A, PRKACB
19
Hide members
8.7PRKACB, PRKACG, PRKAR1A, PRKACA, GNAS
208.7PRKAR1A, GNAS, PRKACA, PRKACB, PRKACG
21
G-protein signaling G-Protein alpha-i signaling cascades
Hide members
8.7PRKACA, PRKAR1A, PRKACG, GNAS, PRKACB
22
wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
8.7GNAS, PRKACB, PRKACG, PRKAR1A, PRKACA
23
Hide members
8.7PRKACG, PRKACB, PRKAR1A, GNAS, PRKACA
248.7GNAS, PRKACG, PRKAR1A, PRKACB, PRKACA
25
Hide members
8.7PRKACG, PRKACA, PRKACB, GNAS, PRKAR1A
26
Hide members
8.7PRKACA, PRKACB, PRKACG, GNAS, PRKAR1A
27
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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8.7GNAS, PRKACA, PRKACB, PRKACG, PRKAR1A
28
Development Dopamine D2 receptor transactivation of EGFR
Hide members
8.7PRKACG, PRKAR1A, GNAS, PRKACB, PRKACA
298.7NR3C1, ESR2, PRKACB, PRKAR1A, CTNNB1, PRKACA
308.6CTNNB1, PRKAR1A, PRKACB, PRKACA, PRKACG
31
Development A3 receptor signaling
Hide members
8.6PRKACA, PRKACB, CTNNB1, PRKAR1A, PRKACG
32
Hide members
8.6PRKACB, PRKACA, PRKACG, GNAS, CTNNB1
338.5PRKACG, GNAS, PRKACB, PRKACA, CYP19A1
34
Signal transduction cAMP signaling
Hide members
8.5PRKACB, PRKACG, PRKAR1A, PDE8B, GNAS, PRKACA
35
Hide members
8.5IGFBP2, PRKACA, GNAS, PRKAR1A, PRKACB
368.5PRKACG, PRKACB, SMARCA4, PRKAR1A, PRKACA
378.5GNAS, PRKACB, PRKACA, PRKACG, ESR1
38
Hide members
8.5PRKAR1A, PRKACG, PRKACA, POMC, PRKACB, GNAS
39
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
8.4PRKACB, PRKACG, NR3C1, PRKACA, CYP19A1
40
Hide members
8.4PRKACG, PDE11A, PRKACB, PRKACA, GNAS, PDE8B
41
Hide members
8.4PRKACG, PRKACA, PRKAR1A, PDE11A, GNAS, PRKACB
428.4PRKACB, PRKACG, CTNNB1, ESR1, PRKACA
43
Development A2B receptor- action via G-protein alpha s
Hide members
8.4PRKAR1A, PRKACA, PRKACB, PRKACG, GNAS, CTNNB1
44
Hide members
8.4PRKACA, PRKACB, GNAS, PRKACG, CTNNB1, PRKAR1A
45
Hide members
8.3POMC, CTNNB1, GNAS, PRKACA, PRKACG, PRKACB
468.1POMC, PRKACA, PRKACB, PRKACG, NR3C1, SMARCA4
47
Development Ligand-independent activation of ESR1 and ESR2
Hide members
8.0PRKACB, GNAS, PRKAR1A, PRKACG, ESR2, ESR1
48
Hide members
8.0PRKACA, CTNNB1, PRKAR1A, PRKACB, ESR1, ESR2
49
Development Endothelin-1/EDNRA signaling
Hide members
7.9GNAS, CTNNB1, PRKACG, PRKACB, PRKACA, ESR2
50
Hide members
7.0PRKACG, PRKACB, PRKACA, POMC, PGR, ESR1

Compounds for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.0IGFBP2
2dexamethasone45 50 29 1112.9POMC, CTNNB1, PRKACA, NR3C1
3idoxifene459.7CYP19A1, ESR1, PGR
4betamethasone45 1110.7NR3C1, SYP, POMC, CYP19A1
5trilostane45 1110.6ESR2, NR3C1, ESR1, PGR
6estradiol benzoate459.5ESR2, ESR1, PGR, CYP19A1
7aminoglutethimide45 1110.5ESR1, POMC, NR3C1, CYP19A1
8leuprolide acetate459.5CYP19A1, PGR, ESR1, ESR2
9exemestane50 45 60 1112.4ESR2, ESR1, CYP19A1, PGR
10bisphenol a459.4ESR1, PGR, ESR2, CYP19A1
11clomiphene citrate459.4PGR, CYP19A1, ESR2, ESR1
12letrozole45 50 60 1112.4ESR1, PGR, CYP19A1, SYP, ESR2
13toremifene45 1110.4ESR1, ESR2, CYP19A1, PGR
14camps-sp, triethylammonium salt609.3PRKACG, PRKACB, PRKACA, PRKAR1A
15pka inhibitor fragment (6-22) amide609.3PRKAR1A, PRKACA, PRKACB, PRKACG
16h 89 dihydrochloride609.3PRKACB, PRKACA, PRKAR1A, PRKACG
17pki 14-22 amide, myristoylated609.3PRKACA, PRKACB, PRKACG, PRKAR1A
18megestrol acetate459.3POMC, CYP19A1, PGR, NR3C1, ESR1
19nandrolone45 2410.3PGR, ESR2, NR3C1, CYP19A1, ESR1
20fulvestrant45 50 29 1112.3ESR2, ESR1, PGR, CYP19A1
21cyproteroneacetate459.2CYP19A1, PGR, CTNNB1, NR3C1
22megestrol45 1110.2PGR, NR3C1, CYP19A1
23dopamine45 29 11 2412.1GNAS, ESR2, NR3C1, NCAM1, CHGA, CTNNB1
24forskolin45 50 1111.1PRKACA, PRKAR1A, IGFBP2, POMC
25kt 572045 29 6011.1PRKAR1A, PRKACG, PRKACB, PRKACA
26levonorgestrel45 60 29 1112.1PGR, CYP19A1, ESR2, ESR1
27gaba459.0PGR, POMC, CHGA, NR3C1, NCAM1, SYP
284-hydroxytamoxifen458.9ESR1, CTNNB1, CYP19A1, PGR, ESR2, NR3C1
29dhea458.7NR3C1, ESR2, CYP19A1, POMC, IGFBP2
30mifepristone45 60 29 1111.7ESR2, CYP19A1, PGR, ESR1, NR3C1, POMC
31vitamin d458.7CHGA, ESR2, ESR1, CYP19A1, NR3C1, PRKAR1A
32acth458.6GNAS, SYP, CHGA, IGFBP2, POMC, NR3C1
33paraffin458.6CTNNB1, PGR, ESR1, NCAM1, SYP, CHGA
34bicalutamide45 60 1110.5IGFBP2, CYP19A1, ESR2, ESR1, CTNNB1, CHGA
35steroidal458.4PGR, ESR2, ESR1, CYP19A1, IGFBP2, NR3C1
36progestins458.4ESR2, ESR1, CYP19A1, IGFBP2, NR3C1, PGR
37doxorubicin45 50 1110.4PGR, NCAM1, NR3C1, CYP19A1, ESR1, ESR2
38gnrh458.4ESR2, PGR, CYP19A1, IGFBP2, NCAM1, GNAS
39progestin458.2ESR2, ESR1, PGR, CYP19A1, IGFBP2, NR3C1
40tamoxifen45 50 29 1111.1ESR1, PGR, ESR2, CYP19A1, IGFBP2, CHGA
41dihydrotestosterone45 29 11 2411.1CTNNB1, ESR2, IGFBP2, CYP19A1, PGR, ESR1
42steroid458.0GNAS, CYP19A1, PRKAR1A, SYP, IGFBP2, POMC
43cysteine458.0CTNNB1, SMARCA4, ESR2, PGR, CHGA, GNAS
44estradiol45 11 2410.0ESR1, POMC, CYP19A1, PGR, IGFBP2, ESR2
45vegf457.5ESR1, POMC, ESR2, PGR, IGFBP2, NR3C1
46retinoic acid45 248.3CHGA, PGR, ESR2, ESR1, CTNNB1, CYP19A1
47cyclic amp45 248.3CNC, PRKACA, SYP, CHGA, PRKACB, GNAS
48arginine457.1CYP19A1, PRKAR1A, SMARCA4, POMC, CHGA, GNAS
49testosterone45 60 11 249.7PGR, ESR1, SMARCA4, CYP19A1, POMC, IGFBP2
50progesterone45 60 29 11 2410.5IGFBP2, POMC, CYP19A1, PGR, ESR1, ESR2

GO Terms for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1AMP-activated protein kinase complexGO:0315889.8PRKACA, PRKAR1A
2cAMP-dependent protein kinase complexGO:0059529.6PRKAR1A, PRKACA, PRKACB
3membraneGO:0160208.6ESR1, CYP19A1, NR3C1, PRKACA, CTNNB1, GNAS
4nucleoplasmGO:0056548.4CTNNB1, PRKACB, NR3C1, PGR, ESR1, ESR2
5cytosolGO:0058297.5GNAS, PDE11A, CTNNB1, PRKAR1A, PRKACG, PRKACB

Biological processes related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1glial cell fate determinationGO:00740310.0CTNNB1, SMARCA4
2uterus developmentGO:06006510.0ESR2, ESR1
3vagina developmentGO:0600689.8ESR1, ESR2
4negative regulation of androgen receptor signaling pathwayGO:0607669.8SMARCA4, ESR2
5embryonic hindlimb morphogenesisGO:0351169.8SMARCA4, CTNNB1, GNAS
6transcription initiation from RNA polymerase II promoterGO:0063679.4NR3C1, PGR, ESR1, ESR2
7triglyceride catabolic processGO:0194339.4PRKACG, PRKACB, PRKACA
8positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4SMARCA4, ESR2, ESR1
9gluconeogenesisGO:0060949.4PRKACA, PRKACB, PRKACG
10activation of protein kinase A activityGO:0341999.3PRKAR1A, PRKACG, PRKACB, PRKACA
11activation of phospholipase C activityGO:0072029.2PRKACA, PRKACB, PRKACG, PRKAR1A
12fibroblast growth factor receptor signaling pathwayGO:0085439.2PRKAR1A, PRKACG, PRKACB, PRKACA
13epidermal growth factor receptor signaling pathwayGO:0071739.1PRKACA, PRKACB, PRKACG, PRKAR1A
14response to estradiol stimulusGO:0323559.1CTNNB1, IGFBP2, ESR1
15cellular response to glucagon stimulusGO:0713779.0GNAS, PRKAR1A, PRKACG, PRKACB, PRKACA
16water transportGO:0068339.0PRKACA, PRKACB, PRKACG, PRKAR1A, GNAS
17regulation of insulin secretionGO:0507969.0PRKACA, PRKACB, PRKACG, PRKAR1A, GNAS
18energy reserve metabolic processGO:0061129.0GNAS, PRKAR1A, PRKACG, PRKACB, PRKACA
19neurotrophin TRK receptor signaling pathwayGO:0480118.8PRKACA, PRKACB, PRKACG, PRKAR1A
20intracellular protein kinase cascadeGO:0072438.8PRKACG, PRKACB, PRKACA
21transmembrane transportGO:0550858.8GNAS, PRKAR1A, PRKACG, PRKACB, PRKACA
22blood coagulationGO:0075968.7GNAS, PDE11A, PRKAR1A, PRKACG, PRKACB, PRKACA
23signal transductionGO:0071656.7ESR2, PDE11A, PRKAR1A, PRKACG, PRKACB, PRKACA

Molecular functions related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:0340569.9ESR2, ESR1
2estrogen receptor activityGO:0302849.8ESR2, ESR1
3core promoter sequence-specific DNA bindingGO:0010469.8ESR2, ESR1
43,5-cyclic-nucleotide phosphodiesterase activityGO:0041149.7PDE11A, PDE8B
5steroid hormone receptor activityGO:0037079.6PGR, ESR1, ESR2
6steroid bindingGO:0054969.4ESR2, ESR1, PGR, NR3C1
7cAMP-dependent protein kinase activityGO:0046919.3PRKACG, PRKACB, PRKACA
8enzyme bindingGO:0198999.1CTNNB1, PGR, ESR1, ESR2

Products for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

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Sources for Primary Pigmented Nodular Adrenocortical Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet