MCID: PRM051
MIFTS: 55

Primary Pigmented Nodular Adrenocortical Disease malady

Categories: Genetic diseases, Rare diseases, Reproductive diseases, Endocrine diseases

Aliases & Classifications for Primary Pigmented Nodular Adrenocortical Disease

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Aliases & Descriptions for Primary Pigmented Nodular Adrenocortical Disease:

Name: Primary Pigmented Nodular Adrenocortical Disease 10 45 12 51
Ppnad 45 51
 
Pigmented Nodular Adrenocortical Disease, Primary, 2 36
Pigmented Nodular Adrenocortical Disease, Primary, 1 36

Characteristics:

Orphanet epidemiological data:

51
primary pigmented nodular adrenocortical disease:
Inheritance: Autosomal dominant; Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology10 DOID:0060280
Orphanet51 189439
ICD10 via Orphanet28 E24.8
UMLS65 C1864846, C1864851

Summaries for Primary Pigmented Nodular Adrenocortical Disease

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Disease Ontology:10 An adrenal cortex disease characterized by small to normal sized adrenal glands containing multiple small cortical pigmented nodules.

MalaCards based summary: Primary Pigmented Nodular Adrenocortical Disease, also known as ppnad, is related to pigmented nodular adrenocortical disease, primary, 3 and pigmented nodular adrenocortical disease, primary, 4, and has symptoms including hypercortisolism, abnormality of the genital system and diabetes mellitus. An important gene associated with Primary Pigmented Nodular Adrenocortical Disease is PRKAR1A (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and G alpha (s) signalling events. Affiliated tissues include breast, adrenal gland and cortex, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Related Diseases for Primary Pigmented Nodular Adrenocortical Disease

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Diseases in the Primary Pigmented Nodular Adrenocortical Disease family:

Pigmented Nodular Adrenocortical Disease, Primary, 2 Pigmented Nodular Adrenocortical Disease, Primary, 3
Pigmented Nodular Adrenocortical Disease, Primary, 1 Pigmented Nodular Adrenocortical Disease, Primary, 4

Diseases related to Primary Pigmented Nodular Adrenocortical Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1pigmented nodular adrenocortical disease, primary, 311.8
2pigmented nodular adrenocortical disease, primary, 411.8
3pigmented nodular adrenocortical disease, primary, 211.7
4pigmented nodular adrenocortical disease, primary, 111.7
5lung squamous cell carcinoma10.7POMC, SYP
6ureter transitional cell carcinoma10.7CHGA, SYP
7gallbladder small cell carcinoma10.7CHGA, SYP
8pediculus humanus capitis infestation10.7CHGA, SYP
9childhood malignant hemangiopericytoma10.7CHGA, SYP
10classic pulmonary blastoma10.7CTNNB1, SYP
11oxyphilic adenoma10.7CHGA, SYP
12perineural angioma10.7CHGA, SYP
13middle cerebral artery infarction10.7CHGA, SYP
14thoracic benign neoplasm10.7CHGA, SYP
15urinary system disease10.7CHGA, SYP
16peritoneal serous adenocarcinoma10.7CHGA, SYP
17goldmann-favre syndrome10.6CHGA, CTNNB1
18urethra adenocarcinoma10.6CHGA, SYP
19scabies10.6CHGA, SYP
20nodular tenosynovitis10.6ESR1, SYP
21graphite pneumoconiosis10.6CHGA, SYP
22wheat allergy10.6CHGA, SYP
23ovarian cystic teratoma10.6CHGA, POMC
24pinheiro freire-maia miranda syndrome10.6CHGA, SYP
25villous adenocarcinoma10.6CHGA, POMC
26cushing's syndrome10.6
27corneal ectasia10.6CHGA, POMC
28pancreatic solid pseudopapillary carcinoma10.6CHGA, SYP
29cerebellar astrocytoma10.5CHGA, SYP
30adrenal gland pheochromocytoma10.5POMC, PRKAR1A, SYP
31cardiovascular organ benign neoplasm10.5CTNNB1, POMC, SYP
32syringoma10.5ESR1, PGR
33endocrine organ benign neoplasm10.4ESR1, PGR
34cervical benign neoplasm10.4ESR1, PGR
35ovary neuroendocrine neoplasm10.4CTNNB1, PGR
36large bowel leiomyoma10.4ESR1, PGR
37bile duct cystadenoma10.4ESR1, PGR
38glaucoma iridogoniodysgenesia10.4ESR1, PGR
39venous tributary occlusion of retina10.4ESR1, PGR
40mixed type thymoma10.4CHGA, POMC, SYP
41gastrointestinal system disease10.4CHGA, SYP
42gangliocytoma10.4NCAM1, SYP
43peroneal nerve paralysis10.4ESR1, PGR
44situs inversus10.4ESR1, PGR
45colon mucinous adenocarcinoma10.4CHGA, CTNNB1, SYP
46pancreatic signet ring cell adenocarcinoma10.4NCAM1, SYP
47vulvar squamous papilloma10.4ESR1, PGR
48childhood choriocarcinoma of the ovary10.4ESR1, PGR
49extragonadal nonseminomatous germ cell tumor10.4ESR1, PGR
50esophageal adenoid cystic carcinoma10.4ESR1, PGR

Graphical network of the top 20 diseases related to Primary Pigmented Nodular Adrenocortical Disease:



Diseases related to primary pigmented nodular adrenocortical disease

Symptoms for Primary Pigmented Nodular Adrenocortical Disease

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Symptoms:

 51 (show all 15)
  • adrenal glands anomalies
  • cortico-adrenal hyperplasia/hypersecretion
  • striae
  • thin skin
  • chronic arterial hypertension
  • diabetes mellitus
  • late puberty/hypogonadism/hypogenitalism
  • muscle weakness/flaccidity
  • muscle hypotrophy/atrophy/dystrophy/agenesis/amyotrophy
  • osteoporosis/osteopenia/demineralisation/osteomalacia/rickets
  • mutiple fractures/bone fragility
  • truncal obesity
  • short stature/dwarfism/nanism
  • asthenia/fatigue/weakness
  • myopathy

HPO human phenotypes related to Primary Pigmented Nodular Adrenocortical Disease:

(show all 13)
id Description Frequency HPO Source Accession
1 hypercortisolism hallmark (90%) HP:0001578
2 abnormality of the genital system typical (50%) HP:0000078
3 diabetes mellitus typical (50%) HP:0000819
4 hypertension typical (50%) HP:0000822
5 thin skin typical (50%) HP:0000963
6 striae distensae typical (50%) HP:0001065
7 muscle weakness typical (50%) HP:0001324
8 truncal obesity typical (50%) HP:0001956
9 recurrent fractures typical (50%) HP:0002757
10 skeletal muscle atrophy typical (50%) HP:0003202
11 short stature typical (50%) HP:0004322
12 reduced bone mineral density typical (50%) HP:0004349
13 myopathy occasional (7.5%) HP:0003198

Drugs & Therapeutics for Primary Pigmented Nodular Adrenocortical Disease

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Drugs for Primary Pigmented Nodular Adrenocortical Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EpinephrineapprovedPhase 283451-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenaclick
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Auvi-q
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine bitartrate
Epinephrine chloride
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr
Epipen Jr.
Epipen Jr. Auto-Injector
Epipen jr
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
 
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
Primatene Mist Refill
Prime Asthma Relief
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
2RacepinephrinePhase 2834
3Epinephryl boratePhase 2834
4Adrenocorticotropic HormonePhase 2133

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Efficacy and Safety of Osilodrostat in Cushing's SyndromeRecruitingNCT02468193Phase 2
2Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney ComplexRecruitingNCT00001452
3Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the CARNEY Complex (CNC)Active, not recruitingNCT00668291

Search NIH Clinical Center for Primary Pigmented Nodular Adrenocortical Disease


Cochrane evidence based reviews: pigmented nodular adrenocortical disease, primary, 2

Genetic Tests for Primary Pigmented Nodular Adrenocortical Disease

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Anatomical Context for Primary Pigmented Nodular Adrenocortical Disease

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MalaCards organs/tissues related to Primary Pigmented Nodular Adrenocortical Disease:

33
Breast, Adrenal gland, Cortex, Adrenal cortex, Bone, Lung, Ovary

Animal Models for Primary Pigmented Nodular Adrenocortical Disease or affiliated genes

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MGI Mouse Phenotypes related to Primary Pigmented Nodular Adrenocortical Disease:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4CHGA, CTNNB1, ESR1, ESR2, PDE8B, POMC
2MP:00020068.2CTNNB1, ESR1, ESR2, PGR, POMC, PRKACA
3MP:00053797.9CHGA, CTNNB1, ESR1, ESR2, PGR, POMC
4MP:00053857.7CHGA, CTNNB1, ESR1, ESR2, PGR, POMC
5MP:00036316.7CTNNB1, ESR1, ESR2, NCAM1, PDE11A, POMC
6MP:00053866.4CTNNB1, ESR1, ESR2, NCAM1, PDE11A, PGR

Publications for Primary Pigmented Nodular Adrenocortical Disease

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Articles related to Primary Pigmented Nodular Adrenocortical Disease:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Use of 3-Dimensional Volumetric Modeling of Adrenal Gland Size in Patients with Primary Pigmented Nodular Adrenocortical Disease. (27065461)
2016
2
Hormonal, Radiological, NP-59 Scintigraphy, and Pathological Correlations in Patients With Cushing's Syndrome Due to Primary Pigmented Nodular Adrenocortical Disease (PPNAD). (26390100)
2015
3
mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD). (24865460)
2014
4
Does somatostatin have a role in the regulation of cortisol secretion in primary pigmented nodular adrenocortical disease (ppnad)? a clinical and in vitro investigation. (24512486)
2014
5
A rare case of familial Cushing's syndrome with a common presentation of weight gain due to a mutation of the PRKAR1A gene causing isolated primary pigmented nodular adrenocortical disease. (24859511)
2014
6
A novel PRKAR1A gene mutation associated with primary pigmented nodular adrenocortical disease. (24978147)
2014
7
Primary pigmented nodular adrenocortical disease: the original 4 cases revisited after 30 years for follow-up, new investigations, and molecular genetic findings. (24805858)
2014
8
Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome. (23065993)
2013
9
An unusual presentation of Carney complex with diffuse primary pigmented nodular adrenocortical disease on one adrenal gland and a nonpigmented adrenocortical adenoma and focal primary pigmented nodular adrenocortical disease on the other. (22785148)
2012
10
Causes and consequences of abandoning one-stage bilateral adrenalectomy recommended in primary pigmented nodular adrenocortical disease--case presentation. (21932601)
2011
11
Children with Cushing's syndrome: Primary Pigmented Nodular Adrenocortical Disease should always be suspected. (20924687)
2011
12
A case of subclinical Cushing syndrome due to primary pigmented nodular adrenocortical disease associated with adrenocortical adenoma. (21442380)
2011
13
Primary pigmented nodular adrenocortical disease: a case report in a 7-year-old girl. (21648292)
2011
14
Primary pigmented nodular adrenocortical disease. (21717412)
2011
15
Laparoscopic unilateral adrenalectomy in children for isolated primary pigmented nodular adrenocortical disease (PPNAD): case report and literature review. (20099223)
2010
16
Familial isolated primary pigmented nodular adrenocortical disease associated with a novel low penetrance PRKAR1A gene splice site mutation. (20190548)
2010
17
CT findings of primary pigmented nodular adrenocortical disease: rare cause of ACTH-independent Cushing syndrome. (20489078)
2010
18
Primary pigmented nodular adrenocortical disease presenting with a unilateral adrenocortical nodule treated with bilateral laparoscopic adrenalectomy: a case report. (20670433)
2010
19
Association of the M1V PRKAR1A mutation with primary pigmented nodular adrenocortical disease in two large families. (19915019)
2010
20
MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling. (19351815)
2009
21
The paradoxical increase in cortisol secretion induced by dexamethasone in primary pigmented nodular adrenocortical disease involves a glucocorticoid receptor-mediated effect of dexamethasone on protein kinase A catalytic subunits. (19383776)
2009
22
Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease, and other corticotropin-independent lesions. (18491255)
2008
23
Expression of progesterone and estradiol receptors in normal adrenal cortex, adrenocortical tumors, and primary pigmented nodular adrenocortical disease. (18508999)
2008
24
Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). (18419788)
2008
25
Primary pigmented nodular adrenocortical disease reveals insulin-like growth factor binding protein-2 regulation by protein kinase A. (17280861)
2007
26
Primary pigmented nodular adrenocortical disease and Cushing's syndrome. (18209861)
2007
27
Primary pigmented nodular adrenocortical disease (PPNAD) and pituitary adenoma in a boy with sporadic Carney complex due to a novel, de novo paternal PRKAR1A mutation (R96X). (17396442)
2007
28
A PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease in 12 kindreds. (16464939)
2006
29
Primary pigmented nodular adrenocortical disease associated with Carney complex: case report and literature review. (17322955)
2006
30
Primary pigmented nodular adrenocortical disease: report of 5 cases. (16701022)
2006
31
Bilateral adrenal Cushing's syndrome: macronodular adrenal hyperplasia and primary pigmented nodular adrenocortical disease. (15850852)
2005
32
Cyclical Cushing syndrome presenting in infancy: an early form of primary pigmented nodular adrenocortical disease, or a new entity? (15240590)
2004
33
Clinical and molecular genetics of primary pigmented nodular adrenocortical disease. (15761532)
2004
34
Primary pigmented nodular adrenocortical disease: paradoxical responses of cortisol secretion to dexamethasone occur in vitro and are associated with increased expression of the glucocorticoid receptor. (12915689)
2003
35
Carney complex, a familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease: a case report. (12670039)
2002
36
Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. (12213893)
2002
37
Paradoxical response to dexamethasone in the diagnosis of primary pigmented nodular adrenocortical disease. (10523219)
1999
38
Synaptophysin immunoreactivity in primary pigmented nodular adrenocortical disease: neuroendocrine properties of tumors associated with Carney complex. (10084605)
1999
39
Primary pigmented nodular adrenocortical disease: reevaluation of a patient with carney complex 27 years after unilateral adrenalectomy. (9100606)
1997
40
Relapse of Cushing's syndrome following the treatment of primary pigmented nodular adrenocortical disease by unilateral adrenalectomy. (8811225)
1996
41
Cushing's syndrome due to primary pigmented nodular adrenocortical disease--a case report reviews of the literature. (7626560)
1995
42
Use of a two-site immunoradiometric assay to resolve a factitious elevation of ACTH in primary pigmented nodular adrenocortical disease. (8186827)
1994
43
Bilateral primary pigmented nodular adrenocortical disease--a case of report describing a rare cause of Cushing's syndrome. (7786440)
1994
44
Carney's complex with primary pigmented nodular adrenocortical disease and spotty pigmentations. (8495049)
1993
45
Carney's complex of primary pigmented nodular adrenocortical disease and pigmentous and myxomatous lesions. (2711295)
1989
46
Primary pigmented nodular adrenocortical disease. A light and electron microscopic study of eight cases. (2679153)
1989
47
Familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease. Reinvestigation 50 years later. (2586567)
1989
48
Cushing's syndrome resulting from primary pigmented nodular adrenocortical disease. (3752018)
1986
49
Primary pigmented nodular adrenocortical disease: diagnosis and management. (3787476)
1986
50
Bilateral primary pigmented nodular adrenocortical disease. Rare cause of the Cushing syndrome. (6329005)
1984

Variations for Primary Pigmented Nodular Adrenocortical Disease

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Expression for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

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Search GEO for disease gene expression data for Primary Pigmented Nodular Adrenocortical Disease.

Pathways for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

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Pathways related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idSuper pathwaysScoreTop Affiliating Genes
19.5ESR1, ESR2
29.4CHGA, PDE11A, PDE8B, POMC
39.2PRKACA, PRKACB, PRKACG
49.2PRKACA, PRKACB, PRKACG
59.2PRKACA, PRKACB, PRKACG
69.2PRKACA, PRKACB, PRKACG
78.9CHGA, PRKACA, PRKACB, PRKACG
88.9CHGA, PRKACA, PRKACB, PRKACG
98.8ESR1, PRKACA, PRKACB, PRKACG
10
Show member pathways
8.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
11
Show member pathways
8.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
12
Show member pathways
8.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
13
Show member pathways
8.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
14
Show member pathways
8.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
15
Show member pathways
8.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
16
Show member pathways
8.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
17
Show member pathways
8.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
188.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
19
Show member pathways
8.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
20
Show member pathways
8.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
218.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
228.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
238.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
248.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
258.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
268.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
278.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
288.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
298.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
308.6PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
31
Show member pathways
8.6CTNNB1, POMC, PRKACA, PRKACB, PRKACG
328.6CHGA, POMC, PRKACA, PRKACB, PRKACG
338.5CTNNB1, ESR1, PRKACA, PRKACB, PRKACG
348.5CTNNB1, ESR1, PRKACA, PRKACB, PRKACG
358.4NCAM1, PRKACA, PRKACB, PRKACG
36
Show member pathways
8.4PDE8B, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
378.3POMC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
38
Show member pathways
8.3POMC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
39
Show member pathways
8.3CTNNB1, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
40
Show member pathways
8.3CTNNB1, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
41
Show member pathways
8.3CTNNB1, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
42
Show member pathways
8.3CTNNB1, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
438.3CTNNB1, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
44
Show member pathways
8.3CTNNB1, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
458.2CTNNB1, ESR2, PRKACA, PRKACB, PRKAR1A, PRKAR1B
46
Show member pathways
8.0CHGA, POMC, PRKACA, PRKACB, PRKACG, PRKAR1A
47
Show member pathways
7.7ESR1, ESR2, PRKACA, PRKACB, PRKACG, PRKAR1A
48
Show member pathways
7.6CHGA, CTNNB1, ESR1, ESR2, PRKACA, PRKACB
49
Show member pathways
7.4CTNNB1, ESR1, ESR2, PRKACA, PRKACB, PRKACG
50
Show member pathways
5.3CHGA, CTNNB1, ESR1, NCAM1, PDE11A, PDE8B

GO Terms for genes affiliated with Primary Pigmented Nodular Adrenocortical Disease

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Cellular components related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ciliary baseGO:009754610.1PRKACA, PRKAR1A, PRKAR1B
2cytosolGO:00058298.4CTNNB1, ESR1, PRKACA, PRKACB, PRKAR1A, PRKAR1B

Biological processes related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cAMP-dependent protein kinase activityGO:200048010.6PRKAR1A, PRKAR1B
2activation of protein kinase A activityGO:003419910.4PRKACA, PRKACB
3Sertoli cell developmentGO:006000910.3ESR1, ESR2
4Sertoli cell proliferationGO:006001110.2ESR1, ESR2
5regulation of neuron apoptotic processGO:004352310.2ESR1, ESR2
6response to hormoneGO:000972510.1CTNNB1, ESR2
7triglyceride catabolic processGO:00194339.9PRKACA, PRKACB, PRKACG
8activation of phospholipase C activityGO:00072029.7PRKACA, PRKACB, PRKACG
9renal water homeostasisGO:00030919.6PRKACA, PRKACG, PRKAR1A, PRKAR1B
10negative regulation of neuron deathGO:19012159.4CHGA, CTNNB1, ESR1, ESR2
11water transportGO:00068339.4PRKACB, PRKACG, PRKAR1A, PRKAR1B
12cellular response to glucagon stimulusGO:00713779.2PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
13epidermal growth factor receptor signaling pathwayGO:00071739.1NCAM1, PRKACG, PRKAR1A, PRKAR1B
14energy reserve metabolic processGO:00061129.0PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
15fibroblast growth factor receptor signaling pathwayGO:00085438.2NCAM1, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
16innate immune responseGO:00450877.8NCAM1, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
17neurotrophin TRK receptor signaling pathwayGO:00480117.7NCAM1, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B
18signal transductionGO:00071657.7CTNNB1, PGR, POMC, PRKACA, PRKACB, PRKACG

Molecular functions related to Primary Pigmented Nodular Adrenocortical Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
13,5-cyclic-AMP phosphodiesterase activityGO:000411510.0PDE11A, PDE8B
2cAMP-dependent protein kinase activityGO:00046919.7PRKACB, PRKACG
3core promoter sequence-specific DNA bindingGO:00010469.5ESR1, ESR2

Sources for Primary Pigmented Nodular Adrenocortical Disease

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet