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PPA
MCID: PRM052
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Primary Progressive Aphasia malady |
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Sources: 30NIH Rare Diseases, 31NINDS, 44Wikipedia, 22MalaCards See all sources Export this MalaCard |
NIH Rare Diseases: Primary progressive aphasia (PPA) is a type of dementia characterized by language disturbance, including difficulty making or understanding speech (aphasia). PPA can be part of frontotemporal dementia or Alzheimer disease. Spatial skills and memory usually remain intact. In early stages, PPA often manifests as deficits in naming, word finding, or word comprehension. In late stages, affected individuals often become mute and lose their ability to communicate. In some cases, PPA is inherited in an autosomal dominant fashion and caused by mutations in the GRN gene.PPA can be classified into three distinct variants based on language profiles, which include progressive non-fluent aphasia (PNFA), semantic dementia (SD), and the recently characterized logopenic variant (LPA).30
MalaCards: Primary Progressive Aphasia, also known as primary progressive aphasia (disorder), is related to semantic dementia and aphasia. An important gene associated with Primary Progressive Aphasia is GRN (granulin), and among its related pathways are Alzheimers Disease Pathway and Neuroscience. The compounds thioflavin and thioflavine s have been mentioned in the context of this disorder. Affiliated tissues include brain and temporal lobe, and related mouse phenotypes are other and homeostasis/metabolism. NINDS: Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick?s disease, the name and classification of FTD has been a topic of discussion for over a century.31 Wikipedia: Primary progressive aphasia (PPA) is characterized by progressive language and speech disorders. It was...44 more... |
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Sources: 30NIH Rare Diseases, 31NINDS, 32Novoseek , 43UMLS See all sources |
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for primary progressive aphasia Drug clinical trials:Search ClinicalTrials for primary progressive aphasia Search NIH Clinical Center for primary progressive aphasia Search CenterWatch for primary progressive aphasia |
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Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to primary progressive aphasia:22Brain, Temporal lobe
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to primary progressive aphasia:25
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Sources: 35PubMed See all sources |
Articles related to primary progressive aphasia:
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Sources: 1BioGPS See all sources |
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Sources: 36QIAGEN, 3Cell Signaling Technology See all sources |
Pathways related to primary progressive aphasia according to GeneDecks:
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Sources: 32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB See all sources |
Compounds related to primary progressive aphasia according to GeneDecks:(show all 19)
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Sources: 12Gene Ontology See all sources |
Cellular components related to primary progressive aphasia according to GeneDecks:
Biological processes related to primary progressive aphasia according to GeneDecks:
Molecular functions related to primary progressive aphasia according to GeneDecks:
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