PPMS
MCID: PRM108
MIFTS: 34

Primary Progressive Multiple Sclerosis (PPMS) malady

Genetic diseases, Neuronal diseases, Rare diseases categories

Summaries for Primary Progressive Multiple Sclerosis

About this section
Sources:
9Disease Ontology, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Disease Ontology:9 A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. the rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous.

MalaCards: Primary Progressive Multiple Sclerosis, also known as multiple sclerosis, primary progressive, is related to multiple sclerosis and neuromyelitis optica. An important gene associated with Primary Progressive Multiple Sclerosis is MOG (myelin oligodendrocyte glycoprotein), and among its related pathways are Interferon Signaling and Jak-STAT signaling pathway. The compounds 2,3-cyclic nucleotide and herbimycin a have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Primary Progressive Multiple Sclerosis

About this section
Sources:
9Disease Ontology, 46Novoseek, 63UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

primary progressive multiple sclerosis 9 46
multiple sclerosis, primary progressive 63
primary-progressive ms 9
ppms 9


External Ids:

Disease Ontology9 DOID:0050784

Related Diseases for Primary Progressive Multiple Sclerosis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Primary Progressive Multiple Sclerosis:



Diseases related to primary progressive multiple sclerosis

Symptoms for Primary Progressive Multiple Sclerosis

About this section

Drugs & Therapeutics for Primary Progressive Multiple Sclerosis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Primary Progressive Multiple Sclerosis

Drug clinical trials:

Search ClinicalTrials for Primary Progressive Multiple Sclerosis

Search NIH Clinical Center for Primary Progressive Multiple Sclerosis

Search CenterWatch for Primary Progressive Multiple Sclerosis

Genetic Tests for Primary Progressive Multiple Sclerosis

About this section

Anatomical Context for Primary Progressive Multiple Sclerosis

About this section

Animal Models for Primary Progressive Multiple Sclerosis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Primary Progressive Multiple Sclerosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4PLP1, IL7R, IFNB1, MOG
2MP:00053978.1PLP1, IL7R, IFNB1, MOG

Publications for Primary Progressive Multiple Sclerosis

About this section
Sources:
53PubMed
See all sources

Articles related to Primary Progressive Multiple Sclerosis:

(show all 25)
idTitleAuthorsYear
1
Characteristic cerebrospinal fluid cytokine/chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosis. (23637915)
2013
2
Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis. (24277735)
2013
3
No association between genetic polymorphism at codon 129 of the prion protein gene and primary progressive multiple sclerosis. (21320996)
2011
4
Heterozygous X-linked adrenoleukodystrophy-associated myelopathy mimicking primary progressive multiple sclerosis. (20803344)
2011
5
Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort. (20067515)
2010
6
Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males. (20463744)
2010
7
Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis. (20363033)
2010
8
APOE epsilon status in Hungarian patients with primary progressive multiple sclerosis. (21110240)
2010
9
Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis. (19616314)
2009
10
Tumour necrosis factor alpha gene (TNF-alpha) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis. (19201038)
2009
11
MxA protein--an interferon beta biomarker in primary progressive multiple sclerosis patients. (18549400)
2008
12
Cell surface adhesion molecules and cytokine profiles in primary progressive multiple sclerosis. (17613596)
2007
13
Interferon-beta1b treatment modulates cytokines in patients with primary progressive multiple sclerosis. (17083335)
2006
14
Primary progressive multiple sclerosis as a phenotype of a PLP1 gene mutation. (16130097)
2005
15
Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. (16075257)
2005
16
Autoantibody synthesis in primary progressive multiple sclerosis patients treated with interferon beta-1b. (15645350)
2004
17
Decreased MMP-9 production in primary progressive multiple sclerosis patients. (15327032)
2004
18
Immunologic factors in primary progressive multiple sclerosis. (15218805)
2004
19
Serum gelatinase B/MMP-9 in primary progressive multiple sclerosis patients treated with interferon-beta-1a. (14504963)
2003
20
Interferon-beta-1 b decreased matrix metalloproteinase-9 serum levels in primary progressive multiple sclerosis. (14586607)
2003
21
CTLA4 exon 1 dimorphism is associated with primary progressive multiple sclerosis. (12458055)
2002
22
Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis. (12039409)
2002
23
Monitoring disease activity and progression in primary progressive multiple sclerosis using MRI: sub-voxel registration to identify lesion changes and to detect cerebral atrophy. (11985382)
2002
24
Detailed analysis of the oligodendrocyte myelin glycoprotein gene in four patients with neurofibromatosis 1 and primary progressive multiple sclerosis. (10766898)
2000
25
Immunological profile of patients with primary progressive multiple sclerosis. Expression of adhesion molecules. (10581223)
1999

Variations for Primary Progressive Multiple Sclerosis

About this section

Expression for genes affiliated with Primary Progressive Multiple Sclerosis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Primary Progressive Multiple Sclerosis

Search GEO for disease gene expression data for Primary Progressive Multiple Sclerosis.

Pathways for genes affiliated with Primary Progressive Multiple Sclerosis

About this section
Sources:
51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database
See all sources

Pathways related to Primary Progressive Multiple Sclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4IL7R, IFNB1
2
Show member pathways
Type III interferon signaling39
9.4IL7R, IFNB1

Compounds for genes affiliated with Primary Progressive Multiple Sclerosis

About this section
Sources:
46Novoseek, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB, 12DrugBank
See all sources

Compounds related to Primary Progressive Multiple Sclerosis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
12,3-cyclic nucleotide469.5PLP1, MOG
2herbimycin a46 6210.4IFNB1, IL7R
3acetylcholine46 52 30 25 1213.4PLP1, MOG
4methionine469.0PLP1, IFNB1
5glatiramer acetate46 1210.0PLP1, IFNB1, MOG
6silver469.0PLP1, IFNB1, MOG
7lipid468.8PLP1, IFNB1, MOG

GO Terms for genes affiliated with Primary Progressive Multiple Sclerosis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Primary Progressive Multiple Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.1PLP1, IL7R, MOG, OMG

Biological processes related to Primary Progressive Multiple Sclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surface receptor signaling pathwayGO:0071669.4IL7R, IFNB1
2B cell proliferationGO:0421009.3IL7R, IFNB1
3positive regulation of gene expressionGO:0106289.0PLP1, IL7R

Products for genes affiliated with Primary Progressive Multiple Sclerosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Primary Progressive Multiple Sclerosis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet