MCID: PRM108
MIFTS: 29

Primary Progressive Multiple Sclerosis malady

Genetic diseases (common) category

Aliases & Classifications for Primary Progressive Multiple Sclerosis

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS
See all sources

Primary Progressive Multiple Sclerosis, Aliases & Descriptions:

Name: Primary Progressive Multiple Sclerosis 9 43
Multiple Sclerosis, Primary Progressive 60
 
Primary-Progressive Ms 9
Ppms 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

Disease Ontology9 DOID:0050784

Summaries for Primary Progressive Multiple Sclerosis

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Disease Ontology:9 A multiple sclerosis that is characterized by steady worsening of neurologic functioning, without any distinct relapses or periods of remission. the rate of progression may vary over time, with occasional plateaus or temporary improvements, but the progression is continuous.

MalaCards based summary: Primary Progressive Multiple Sclerosis, also known as multiple sclerosis, primary progressive, is related to neuromyelitis optica and adrenoleukodystrophy. An important gene associated with Primary Progressive Multiple Sclerosis is MOG (myelin oligodendrocyte glycoprotein), and among its related pathways are Interferon Signaling and Jak-STAT signaling pathway. The compounds 2,3-cyclic nucleotide and herbimycin a have been mentioned in the context of this disorder. Affiliated tissues include lymph node, and related mouse phenotypes are immune system and hematopoietic system.

Related Diseases for Primary Progressive Multiple Sclerosis

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Graphical network of the top 20 diseases related to Primary Progressive Multiple Sclerosis:



Diseases related to primary progressive multiple sclerosis

Symptoms for Primary Progressive Multiple Sclerosis

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Drugs & Therapeutics for Primary Progressive Multiple Sclerosis

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Drug clinical trials:

Search ClinicalTrials for Primary Progressive Multiple Sclerosis

Search NIH Clinical Center for Primary Progressive Multiple Sclerosis

Genetic Tests for Primary Progressive Multiple Sclerosis

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Anatomical Context for Primary Progressive Multiple Sclerosis

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MalaCards organs/tissues related to Primary Progressive Multiple Sclerosis:

31
Lymph node

Animal Models for Primary Progressive Multiple Sclerosis or affiliated genes

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MGI Mouse Phenotypes related to Primary Progressive Multiple Sclerosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4PLP1, IL7R, IFNB1, MOG
2MP:00053978.1PLP1, IL7R, IFNB1, MOG

Publications for Primary Progressive Multiple Sclerosis

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Articles related to Primary Progressive Multiple Sclerosis:

(show all 48)
idTitleAuthorsYear
1
Cognitive impairment in a population-based study of patients with multiple sclerosis: differences between late relapsing-remitting, secondary progressive and primary progressive multiple sclerosis. (25903918)
2015
2
Risk Factors Associated with the Onset of Relapsing-Remitting and Primary Progressive Multiple Sclerosis: A Systematic Review. (25802867)
2015
3
Lack of efficacy of mitoxantrone in primary progressive Multiple Sclerosis irrespective of pharmacogenetic factors: a multi-center, retrospective analysis. (25468777)
2015
4
Melatonin treatment improves primary progressive multiple sclerosis: a case report. (25546814)
2015
5
Analysis of genes, pathways and networks involved in disease severity and age at onset in primary-progressive multiple sclerosis. (25583839)
2015
6
Modelling the natural history of primary progressive multiple sclerosis. (24828900)
2014
7
Levels of soluble TNF-RII are increased in serum of patients with primary progressive multiple sclerosis. (24794503)
2014
8
Efficient generation of myelinating oligodendrocytes from primary progressive multiple sclerosis patients by induced pluripotent stem cells. (25254339)
2014
9
Genetics of primary progressive multiple sclerosis. (24507520)
2014
10
Electrophysiological markers and predictors of the disease course in primary progressive multiple sclerosis. (23756680)
2014
11
Retraction notice: Language abilities of patients with primary progressive multiple sclerosis: A preliminary group and case investigation. (24766406)
2014
12
Validating predictors of disease progression in a large cohort of primary-progressive multiple sclerosis based on a systematic literature review. (24651401)
2014
13
Hereditary diffuse leukoencephalopathy with spheroids with phenotype of primary progressive multiple sclerosis. (25311247)
2014
14
Immunoglobulin M oligoclonal bands: biomarker of targetable inflammation in primary progressive multiple sclerosis. (24909126)
2014
15
Temporal and spatial evolution of grey matter atrophy in primary progressive multiple sclerosis. (24099844)
2014
16
Epstein-barr virus in the central nervous system and cervical lymph node of a patient with primary progressive multiple sclerosis. (24918642)
2014
17
Adult-onset vanishing white matter disease as differential diagnosis of primary progressive multiple sclerosis: A case report. (25135182)
2014
18
Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis. (23840674)
2013
19
Treatment of primary progressive multiple sclerosis. (23709215)
2013
20
Characteristic cerebrospinal fluid cytokine/chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosis. (23637915)
2013
21
Possible new modifications for the McDonald 2010 criteria for the diagnosis of primary progressive multiple sclerosis. (23818017)
2013
22
A new model for primary-progressive multiple sclerosis? (24036552)
2013
23
Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis. (24277735)
2013
24
A case of hereditary diffuse leukoencephalopathy with axonal spheroids caused by a de novo mutation in CSF1R masquerading as primary progressive multiple sclerosis. (23698128)
2013
25
A new CSF1R mutation presenting with an extensive white matter lesion mimicking primary progressive multiple sclerosis. (24034409)
2013
26
No association between genetic polymorphism at codon 129 of the prion protein gene and primary progressive multiple sclerosis. (21320996)
2011
27
Heterozygous X-linked adrenoleukodystrophy-associated myelopathy mimicking primary progressive multiple sclerosis. (20803344)
2011
28
Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort. (20067515)
2010
29
Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males. (20463744)
2010
30
Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis. (20363033)
2010
31
APOE epsilon status in Hungarian patients with primary progressive multiple sclerosis. (21110240)
2010
32
Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis. (19616314)
2009
33
Tumour necrosis factor alpha gene (TNF-alpha) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis. (19201038)
2009
34
MxA protein--an interferon beta biomarker in primary progressive multiple sclerosis patients. (18549400)
2008
35
Cell surface adhesion molecules and cytokine profiles in primary progressive multiple sclerosis. (17613596)
2007
36
Interferon-beta1b treatment modulates cytokines in patients with primary progressive multiple sclerosis. (17083335)
2006
37
Primary progressive multiple sclerosis as a phenotype of a PLP1 gene mutation. (16130097)
2005
38
Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis. (16075257)
2005
39
Autoantibody synthesis in primary progressive multiple sclerosis patients treated with interferon beta-1b. (15645350)
2004
40
Decreased MMP-9 production in primary progressive multiple sclerosis patients. (15327032)
2004
41
Immunologic factors in primary progressive multiple sclerosis. (15218805)
2004
42
Serum gelatinase B/MMP-9 in primary progressive multiple sclerosis patients treated with interferon-beta-1a. (14504963)
2003
43
Interferon-beta-1 b decreased matrix metalloproteinase-9 serum levels in primary progressive multiple sclerosis. (14586607)
2003
44
CTLA4 exon 1 dimorphism is associated with primary progressive multiple sclerosis. (12458055)
2002
45
Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis. (12039409)
2002
46
Monitoring disease activity and progression in primary progressive multiple sclerosis using MRI: sub-voxel registration to identify lesion changes and to detect cerebral atrophy. (11985382)
2002
47
Detailed analysis of the oligodendrocyte myelin glycoprotein gene in four patients with neurofibromatosis 1 and primary progressive multiple sclerosis. (10766898)
2000
48
Immunological profile of patients with primary progressive multiple sclerosis. Expression of adhesion molecules. (10581223)
1999

Variations for Primary Progressive Multiple Sclerosis

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Expression for genes affiliated with Primary Progressive Multiple Sclerosis

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Search GEO for disease gene expression data for Primary Progressive Multiple Sclerosis.

Pathways for genes affiliated with Primary Progressive Multiple Sclerosis

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Pathways related to Primary Progressive Multiple Sclerosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4IL7R, IFNB1
2
Show member pathways
Type III interferon signaling36
9.4IL7R, IFNB1

Compounds for genes affiliated with Primary Progressive Multiple Sclerosis

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Compounds related to Primary Progressive Multiple Sclerosis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
12,3-cyclic nucleotide439.5PLP1, MOG
2herbimycin a43 5910.4IFNB1, IL7R
3acetylcholine43 49 28 24 1213.4PLP1, MOG
4methionine439.0PLP1, IFNB1
5glatiramer acetate43 1210.0PLP1, IFNB1, MOG
6silver439.0PLP1, IFNB1, MOG
7lipid438.8PLP1, IFNB1, MOG

GO Terms for genes affiliated with Primary Progressive Multiple Sclerosis

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Cellular components related to Primary Progressive Multiple Sclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058868.1PLP1, IL7R, MOG, OMG

Biological processes related to Primary Progressive Multiple Sclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surface receptor signaling pathwayGO:00071669.4IL7R, IFNB1
2B cell proliferationGO:00421009.3IL7R, IFNB1
3positive regulation of gene expressionGO:00106289.0PLP1, IL7R

Products for genes affiliated with Primary Progressive Multiple Sclerosis

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Primary Progressive Multiple Sclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet